A collection of articles from The J. Craig Venter Institute's Global Ocean Sampling Expedition in PLoS Biology
Illustration: Giovanni Maki
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Research Articles
PLoS Biology
The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific
Rusch DB, Halpern AL, Sutton G, et al.
The Sorcerer II GOS expedition, data sampling, and analysis is described. The immense diversity in the sequence data required novel comparative genomic assembly methods, which uncovered genomic differences that marker-based methods could not.
Supplementary information for this research article is included in the poster "Fragment Recruitment of GOS Data to Finished Microbial Genomes"
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The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe of Protein Families
Yooseph S, Sutton G, Rusch DB, et al.
The GOS data identified 6.12 million predicted proteins covering nearly all known prokaryotic protein families, and several new families. This almost doubles the number of known proteins and shows that we are far from identifying all the proteins in nature.
Structural and Functional Diversity of the Microbial Kinome
Kannan N, Taylor SS, Zhai Y, et al.
Over 45,000 kinases, including 16,000 identified in the GOS expedition, were classified into 20 distinct families. This massive sequence comparison revealed a structural flexibility within eukaryotic protein kinases that helps explain their huge expansion in eukaryotes.
PLoS ONE
Williamson SJ, Rusch DB, Yooseph S, Halpern AL, Heidelberg KB, et al.
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Web Seminar
J. Craig Venter discusses the Global Ocean Sampling expedition and analyses performed on the resulting data. Watch Video
Produced with support from Roche Applied Science.
Zoomable Poster
"Fragment Recruitment of GOS Data to Finished Microbial Genomes" accompanies the research article by Rusch DB, Halpern AL, Sutton G, and colleagues. View Interactive Poster
Produced with support from the J. Craig Venter Institute.
Editorial
Global Ocean Sampling Collection
This special collection in PLoS Biology features research articles from the J. Craig Venter Institute's Global Ocean Sampling expedition, as well as accompanying material highlighting the promise, significance, and challenges of metagenomics
Synopsis
Untapped Bounty: Sampling the Seas to Survey Microbial Biodiversity
Feature
Sorcerer II: The Search for Microbial Diversity Roils the Waters
This feature explores bioprospecting and the legal issues related to collecting and cataloging microbial diversity from oceanic locations around the world.
Essay
Environmental shotgun sequencing promises to reveal novel and fundamental insights into the hidden world of microbes, but the complexity of analysis required to realize this potential poses unique interdisciplinary challenges.
Community Page
CAMERA: A Community Resource for Metagenomics
The CAMERA (Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analysis) community database for metagenomic data deposition is an important first step in developing methods for monitoring microbial communities.