Biology & Life Sciences

Focus Feature – Network Approaches and Applications in Biology

Published October 13, 2017 Curated Collections

This Focus Feature addresses some of the most exciting current opportunities and challenges in the field of Network Biology. The collection of articles includes both primary research papers and reviews covering topics such as (1) Using networks to interpret genetic associations, (2) Network models for development of precision therapeutics, (3) Organization of network data to reveal cell structure, and (4) Understanding the networks that exist among, rather than within, cells.

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Introduction to Network Approaches and Applications in Biology
Review
Research Articles
Focus Feature Editors

Introduction to Network Approaches and Applications in Biology

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blickpixel/ pixabay

PLOS Computational Biology Network approaches and applications in biology
October 12, 2017 Trey Ideker, Ruth Nussinov

Review

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10.1371/journal.pcbi.1005579

PLOS Computational Biology Structural Host-Microbiota Interaction Networks
October 12, 2017 Emine Guven-Maiorov, Chung-Jung Tsai, Ruth Nussinov

Research Articles

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10.1371/journal.pcbi.1005695

PLOS Computational Biology BeWith: A Between-Within method to discover relationships between cancer modules via integrated analysis of mutual exclusivity, co-occurrence and functional interactions
October 12, 2017 Phuong Dao, Yoo-Ah Kim, Damian Wojtowicz, Sanna Madan, Roded Sharan, Teresa Przytycka
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10.1371/journal.pcbi.1005621

PLOS Computational Biology Vicus: Exploiting local structures to improve network-based analysis of biological data
October 12, 2017 Bo Wang, Lin Huang, Yuke Zhu, Anshul Kundaje, Serafim Batzoglou, Anna Goldenberg
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10.1371/journal.pcbi.1005625

PLOS Computational Biology Identifying direct contacts between protein complex subunits from their conditional dependence in proteomics datasets
October 12, 2017 Kevin Drew, Christian Müller, Richard Bonneau, Edward Marcotte
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10.1371/journal.pcbi.1005598

PLOS Computational Biology Network propagation in the cytoscape cyberinfrastructure
October 12, 2017 Daniel Carlin, Barry Demchak, Dexter Pratt, Eric Sage, Trey Ideker
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10.1371/journal.pcbi.1005599

PLOS Computational Biology Systematic, network-based characterization of therapeutic target inhibitors
October 12, 2017 Yao Shen, Mariano Alvarez, Brygida Bisikirska, Alexander Lachmann, Ronald Realubit, Sergey Pampou, Jorida Coku, Charles Karan, Andrea Califano
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10.1371/journal.pcbi.1005580

PLOS Computational Biology Incorporating networks in a probabilistic graphical model to find drivers for complex human diseases
October 12, 2017 Aziz Mezlini, Anna Goldenberg

Focus Feature Editors

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University of California San Diego

University of California San Diego Trey Ideker
October 12, 2017 PLOS Computational Biology, Guest Associate Editor
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National Cancer Institute

Center for Cancer Research, NIH Ruth Nussinov
October 12, 2017 PLOS Computational Biology, Editor-in-Chief

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