Antimicrobial resistance (AMR) has been prioritized by the World Health Organization (WHO) as one of the top 10 global public health threats facing humanity.
Bacterial Antimicrobial Resistance: Surveillance and Prevention
The emergence of pathogenic bacteria that cannot be effectively treated with existing antimicrobials has been prioritised by the World Health Organization as one of the top ten global public health threats facing humanity. The burden of antimicrobial resistance (AMR) is disproportionately observed in low- and middle-income countries (LMICs), particularly those in sub-Saharan Africa. Without intervention, it has been estimated that global deaths attributable to AMR could reach 10 million annually by 2050.
The PLOS Medicine editors, together with guest editors Timothy Walsh, Ramanan Laxminarayan and Ana Cristina Gales, present a Special Issue dedicated to bacterial AMR. This collection of high-quality research articles defines the problem from a One Health perspective highlighting the multi-faceted challenges imposed by drug-resistant bacteria, the vast number of contributing factors, the consequences for health and economics, and interventions that could lessen the burden.
Image Credit: Mycobacterium tuberculosis by CDC, Unsplash
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PLOS Medicine Antimicrobial Resistance: Addressing a Global Threat to Humanity
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PLOS Medicine Understanding the impact of antimicrobial resistance on outcomes of bloodstream infections in low- and middle-income countries
Marlieke de Kraker discusses a systematic review and meta-analysis reporting the magnitude and consequences of bloodstream infections in…
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PLOS Medicine Antimicrobial resistance: Strengthening surveillance for public health action
Antimicrobial resistance (AMR) is among the top ten global public health threats, demanding immediate attention and action.
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PLOS Medicine Collateral impacts of pandemic COVID-19 drive the nosocomial spread of antibiotic resistance: A modelling study
Background: Circulation of multidrug-resistant bacteria (MRB) in healthcare facilities is a major public health problem. These settings…
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PLOS Medicine Impact of antibiotics on gut microbiome composition and resistome in the first years of life in low- to middle-income countries: A systematic review
Background: Inappropriate antimicrobial usage is a key driver of antimicrobial resistance (AMR). Low- and middle-income countries (LMICs)…
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PLOS Medicine Prevalence and clonal diversity of carbapenem-resistant Klebsiella pneumoniae causing neonatal infections: A systematic review of 128 articles across 30 countries
Background: Klebsiella pneumoniae is the most common pathogen causing neonatal infections, leading to high mortality worldwide. Along with…
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PLOS Medicine Implications of reducing antibiotic treatment duration for antimicrobial resistance in hospital settings: A modelling study and meta-analysis
Background: Reducing antibiotic treatment duration is a key component of hospital antibiotic stewardship interventions. However, its…
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PLOS Medicine Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)
Background: There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to…
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PLOS Medicine The impact of inpatient bloodstream infections caused by antibiotic-resistant bacteria in low- and middle-income countries: A systematic review and meta-analysis
Background: Bloodstream infections (BSIs) produced by antibiotic-resistant bacteria (ARB) cause a substantial disease burden worldwide.…
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PLOS Medicine Inappropriate antibiotic prescribing and its determinants among outpatient children in 3 low- and middle-income countries: A multicentric community-based cohort study
Background: Antibiotic resistance is a global public health issue, particularly in low- and middle-income countries (LMICs), where…
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PLOS Medicine Global incidence in hospital-associated infections resistant to antibiotics: An analysis of point prevalence surveys from 99 countries
Background: Hospital-associated infections (HAIs) are an important cause of morbidity and mortality around the world. Many HAIs are caused…