HIV infection continues to pose a critical risk to health in many countries. UNAIDS estimates that as of 2016 the total HIV-infected population was 36.7 million, including 1.8 million people newly…

Climate change and the impacts on health are being increasingly reported and documented. It is expected that with continued rises in global temperature and greenhouse gas emissions the effects on…

Noncommunicable diseases (NCDs) are responsible for two-thirds of the world's deaths, one-fourth of which occur before the age of 60. Nearly 80% of NCD deaths occur in low- and middle-income…

Extraordinary progress has been made to halt and reverse the spread of HIV. However, there is still a long way to go to end the epidemic, as called for in the third Sustainable Development…

Treating onchocerciasis remains a challenge as no drug effectively kills the adult worms. A new orally bioavailable formulation of flubendazole was developed and tested to find out whether it could be…

Cardiovascular disease (CVD) is the number one cause of death and disability globally, with an estimated 17.7 million deaths from CVD in 2015. More than three-quarters of CVD deaths occur in low- and…

Alzheimer’s Disease International (ADI) estimates there will be over 131.5 million people living with dementia by 2050, as well as a shift in burden from the richest to poorest…

Traumatic injury has long been recognized as a neglected disease of extremely high burden. With this Special Issue, PLOS Medicine and guest editors Professor Karim Brohi and Dr Martin Schreiber…

With new HIV infections in Sub-Saharan Africa occurring at a rate of 2.3 million each year, this new collection presents interim results from a large public health intervention of voluntary medical…

Co-infection with more than one pathogen is a continuing challenge in global health, particularly in regions with multiple endemic infectious diseases. Direct and indirect interactions between…