PLOS ONE 2015 Most Impactful

PLOS ONE 2015 Most Impactful

Every year, the team here at PLOS ONE celebrates those studies that have been recognized by the scientific community as the most impactful - through high numbers of views, downloads and citations. These studies reflect the quality and breadth of reach that our authors’ research has. Our commitment at PLOS ONE is to publish all well-performed research and amplify its discoverability so that it reaches communities where it has the most impact. We hope you enjoy this Collection.

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Most Impactful




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Biochemical Research Methods

Biochemistry & Molecular Biology

Biotechnology & Applied Microbiology

Cardiac & Cardiovascular Systems

Cell Biology

Clinical Neurology



Endocrinology & Metabolism

Environmental Sciences

Food Science & Technology

Gastroenterology & Hepatology

Genetics & Heredity

Geosciences, Multidisciplinary


Infectious Diseases

Marine & Freshwater Biology






Pharmacology & Pharmacy

Physics, Multidisciplinary

Plant Sciences


Public, Environmental & Occupational Health

Radiology, Nuclear Medicine & Medical Imaging

Respiratory System

Sport Sciences


Tropical Medicine

Urology & Nephrology

Veterinary Sciences


Biochemical Research Methods


A Mass Spectrometric-Derived Cell Surface Protein Atlas
Bausch-Fluck, Damaris; Hofmann, Andreas; Bock, Thomas; Frei, Andreas P.; Cerciello, Ferdinando

High-Throughput Single-Cell Labeling (Hi-SCL) for RNA-Seq Using Drop-Based Microfluidics
Rotem, Assaf; Ram, Oren; Shoresh, Noam; Sperling, Ralph A.; Schnall-Levin, Michael

Comparative Analysis of Label-Free and 8-Plex iTRAQ Approach for Quantitative Tissue Proteomic Analysis
Latosinska, Agnieszka; Vougas, Konstantinos; Makridakis, Manousos; Klein, Julie; Mullen, William

Impact of Anesthesia and Euthanasia on Metabolomics of Mammalian Tissues: Studies in a C57BL/6J Mouse Model
Overmyer, Katherine A.; Thonusin, Chanisa; Qi, Nathan R.; Burant, Charles F.; Evans, Charles R.

Sequential Superresolution Imaging of Multiple Targets Using a Single Fluorophore
Valley, Christopher C.; Liu, Sheng; Lidke, Diane S.; Lidke, Keith A.

Strategies for Achieving High Sequencing Accuracy for Low Diversity Samples and Avoiding Sample Bleeding Using Illumina Platform
Mitra, Abhishek; Skrzypczak, Magdalena; Ginalski, Krzysztof; Rowicka, Maga

Evaluation of iTRAQ and SWATH-MS for the Quantification of Proteins Associated with Insulin Resistance in Human Duodenal Biopsy Samples
Bourassa, Sylvie; Fournier, Frederic; Nehme, Benjamin; Kelly, Isabelle; Tremblay, Andre

Dissecting Antibodies with Regards to Linear and Conformational Epitopes
Forsstrom, Bjorn; Axnas, Barbara Bislawska; Rockberg, Johan; Danielsson, Hanna; Bohlin, Anna

Single Cell Transcriptome Amplification with MALBAC
Chapman, Alec R.; He, ZI; Lu, Sijia; Yong, Jun; Tan, Longzhi

Quantitative Localization Microscopy: Effects of Photophysics and Labeling Stoichiometry
Nieuwenhuizen, Robert P. J.; Bates, Mark; Szymborska, Anna; Lidke, Keith A.; Rieger, Bernd



Biochemistry & Molecular Biology


Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood
Memczak, Sebastian; Papavasileiou, Panagiotis; Peters, Oliver; Rajewsky, Nikolaus

CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
Stemmer, Manuel; Thumberger, Thomas; Keyer, Maria del Sol; Wittbrodt, Joachim; Mateo, Juan L.

Identification of Real MicroRNA Precursors with a Pseudo Structure Status Composition Approach
Liu, Bin; Fang, Longyun; Liu, Fule; Wang, Xiaolong; Chen, Junjie

A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi
Nodvig, Christina S.; Nielsen, Jakob B.; Kogle, Martin E.; Mortensen, Uffe H.

cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/beta-Catenin Pathway
Huang, Guanli; Zhu, Hua; Shi, Yixiong; Wu, Wenzhi; Cai, Huajie

Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential
Liu, Jie; Wang, Lijuan; Zhao, Feifei; Tseng, Serena; Narayanan, Cyndhavi

Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation
Choi, Yong-Min; Kim, Han-Kyul; Shim, Wooyoung; Anwar, Muhammad Ayaz; Kwon, Ji-Woong

A Compartmental Comparison of Major Lipid Species in a Coral-Symbiodinium Endosymbiosis: Evidence that the Coral Host Regulates Lipogenesis of Its Cytosolic Lipid Bodies
Chen, Hung-Kai; Song, Shin-Ni; Wang, Li-Hsueh; Mayfield, Anderson B.; Chen, Yi-Jyun

Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes
Crispo, M.; Mulet, A. P.; Tesson, L.; Barrera, N.; Cuadro, F.

Continuous Distributed Representation of Biological Sequences for Deep Proteomics and Genomics
Asgari, Ehsaneddin; Mofrad, Mohammad R. K.



Biotechnology & Applied Microbiology


Decellularized Cartilage May Be a Chondroinductive Material for Osteochondral Tissue Engineering
Sutherland, Amanda J.; Beck, Emily C.; Dennis, S. Connor; Converse, Gabriel L.; Hopkins, Richard A.

CRISPR MultiTargeter: A Web Tool to Find Common and Unique CRISPR Single Guide RNA Targets in a Set of Similar Sequences
Prykhozhij, Sergey V.; Rajan, Vinothkumar; Gaston, Daniel; Berman, Jason N.

Overview of a Surface-Ripened Cheese Community Functioning by Meta-Omics Analyses
Dugat-Bony, Eric; Straub, Cecile; Teissandier, Aurelle; Onesime, Djamila; Loux, Valentin

Antagonistic Mechanism of Iturin A and Plipastatin A from Bacillus amyloliquefaciens S76-3 from Wheat Spikes against Fusarium graminearum
Gong, An-Dong; Li, He-Ping; Yuan, Qing-Song; Song, Xiu-Shi; Yao, Wei

Genomics Virtual Laboratory: A Practical Bioinformatics Workbench for the Cloud
Afgan, Enis; Sloggett, Clare; Goonasekera, Nuwan; Makunin, Igor; Benson, Derek

Comparative Secretome Analysis of Trichoderma reesei and Aspergillus niger during Growth on Sugarcane Biomass
Borin, Gustavo Pagotto; Sanchez, Camila Cristina; de Souza, Amanda Pereira; de Santana, Eliane Silva; De Souza, Aline Tieppo

Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in Pediatric Asthma
Perez-Losada, Marcos; Castro-Nallar, Eduardo; Bendall, Matthew L.; Freishtat, Robert J.; Crandall, Keith A.

Bioelectricity Generation and Bioremediation of an Azo-Dye in a Microbial Fuel Cell Coupled Activated Sludge Process
Khan, Mohammad Danish; Abdulateif, Huda; Ismail, Iqbal M.; Sabir, Suhail; Khan, Mohammad Zain

Comprehensive Metabolomic, Lipidomic and Microscopic Profiling of Yarrowia lipolytica during Lipid Accumulation Identifies Targets for Increased Lipogenesis
Pomraning, Kyle R.; Wei, Siwei; Karagiosis, Sue A.; Kim, Young-Mo; Dohnalkova, Alice C.

A High Excision Potential of TALENs for Integrated DNA of HIV-Based Lentiviral Vector
Ebina, Hirotaka; Kanemura, Yuka; Misawa, Naoko; Sakuma, Tetsushi; Kobayashi, Tomoko



Cardiac & Cardiovascular Systems


Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population
Shah, Nigam H.; LePendu, Paea; Bauer-Mehren, Anna; Ghebremariam, Yohannes T.; Iyer, Srinivasan V.

Short-Term Heart Rate Variability-Influence of Gender and Age in Healthy Subjects
Voss, Andreas; Schroeder, Rico; Heitmann, Andreas; Peters, Annette; Perz, Siegfried

Serum CD121a (Interleukin 1 Receptor, Type I): A Potential Novel Inflammatory Marker for Coronary Heart Disease
Liu, Zhengxia; Zhang, Mengyao; Wu, Jin; Zhou, Ping; Liu, Ying

A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population
Cheng, Jie; Cho, Miook; Cen, Jin-Ming; Cai, Meng-yun; Xu, Shun

Virtual Electrophysiological Study of Atrial Fibrillation in Fibrotic Remodeling
McDowell, Kathleen S.; Zahid, Sohail; Vadakkumpadan, Fijoy; Blauer, Joshua; MacLeod, Rob S.

Atrial Fibrillation Is an Independent Risk Factor for Hospital-Acquired Pneumonia
Zhu, Jinxiu; Zhan, Xin; Shi, Ganggang; Yi, Kaihong; Tan, Xuerui

miRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease
Schulte, Christian; Molz, Simon; Appelbaum, Sebastian; Karakas, Mahir; Ojeda, Francisco

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress
Ikeda, Masataka; Ide, Tomomi; Fujino, Takeo; Arai, Shinobu; Saku, Keita

Validity of (Ultra-)Short Recordings for Heart Rate Variability Measurements
Munoz, M. Loretto; van Roon, Arie; Riese, Harriette; Thio, Chris; Oostenbroek, Emma

Protective Effect of Sevoflurane Postconditioning against Cardiac Ischemia/Reperfusion Injury via Ameliorating Mitochondrial Impairment, Oxidative Stress and Rescuing Autophagic Clearance
Yu, Peng; Zhang, Jing; Yu, Shuchun; Luo, Zhenzhong; Hua, FuZhou



Cell Biology


Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods
Baranyai, Tamas; Herczeg, Kata; Onodi, Zsofia; Voszka, Istvan; Modos, Karoly

Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer
Hu, Yibing; Yan, Chang; Mu, Lei; Huang, Kaiyu; Li, Xiaolan

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival
Grosse-Wilde, Anne; d'Herouel, Aymeric Fouquier; McIntosh, Ellie; Ertaylan, Gokhan; Skupin, Alexander

Characterization of RNA from Exosomes and Other Extracellular Vesicles Isolated by a Novel Spin Column-Based Method
Enderle, Daniel; Spiel, Alexandra; Coticchia, Christine M.; Berghoff, Emily; Mueller, Romy

Mitochondrial Dynamics Protein Drp1 Is Overexpressed in Oncocytic Thyroid Tumors and Regulates Cancer Cell Migration
Ferreira-da-Silva, Andre; Valacca, Cristina; Rios, Elisabete; Populo, Helena; Soares, Paula

Cardiac Telocytes and Fibroblasts in Primary Culture: Different Morphologies and Immunophenotypes
Bei, Yihua; Zhou, Qiulian; Fu, Siyi; Lv, Dongchao; Chen, Ping

Tumor Cells Switch to Mitochondrial Oxidative Phosphorylation under Radiation via mTOR-Mediated Hexokinase II Inhibition - A Warburg-Reversing Effect
Lu, Chung-Ling; Qin, Lili; Liu, Hsin-Chen; Candas, Demet; Fan, Ming

miR-34 and p53: New Insights into a Complex Functional Relationship
Navarro, Francisco; Lieberman, Judy

Actin Cytoskeleton Regulation of Epithelial Mesenchymal Transition in Metastatic Cancer Cells
Shankar, Jay; Nabi, Ivan R.

Improved Characterization of EV Preparations Based on Protein to Lipid Ratio and Lipid Properties
Osteikoetxea, Xabier; Balogh, Andrea; Szabo-Taylor, Katalin; Nemeth, Andrea; Szabo, Tames Geza



Clinical Neurology


Validation of the STOP-Bang Questionnaire as a Screening Tool for Obstructive Sleep Apnea among Different Populations: A Systematic Review and Meta-Analysis
Nagappa, Mahesh; Liao, Pu; Wong, Jean; Auckley, Dennis; Ramachandran, Satya Krishna

Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson's Disease
Hasegawa, Satoru; Goto, Sae; Tsuji, Hirokazu; Okuno, Tatsuya; Asahara, Takashi

Validity of Diagnostic Codes for Acute Stroke in Administrative Databases: A Systematic Review
McCormick, Natalie; Bhole, Vidula; Lacaille, Diane; Avina-Zubieta, J. Antonio

Memantine Monotherapy for Alzheimer's Disease: A Systematic Review and Meta-Analysis
Matsunaga, Shinji; Kishi, Taro; Iwata, Nakao

A Comparative Effectiveness Meta-Analysis of Drugs for the Prophylaxis of Migraine Headache
Jackson, Jeffrey L.; Cogbill, Elizabeth; Santana-Davila, Rafael; Eldredge, Christina; Collier, William

The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration
Sachdev, Perminder S.; Lipnicki, Darren M.; Kochan, Nicole A.; Crawford, John D.; Thalamuthu, Anbupalam

A Novel, Open Access Method to Assess Sleep Duration Using a Wrist-Worn Accelerometer
Van Hees, Vincent T.; Sabia, Severine; Anderson, Kirstie N.; Denton, Sarah J.; Oliver, James

Diagnostic Accuracy of I-123-Meta-Iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies: A Multicenter Study
Yoshita, Mitsuhiro; Arai, Heii; Arai, Hiroyuki; Arai, Tetsuaki; Asada, Takashi

Wearable Sensor Use for Assessing Standing Balance and Walking Stability in People with Parkinson's Disease: A Systematic Review
Hubble, Ryan P.; Naughton, Geraldine A.; Silburn, Peter A.; Cole, Michael H.

Sex Differences in Dose Escalation and Overdose Death during Chronic Opioid Therapy: A Population-Based Cohort Study
Kaplovitch, Eric; Gomes, Tara; Camacho, Ximena; Dhalla, Irfan A.; Mamdani, Muhammad M.





Can DNA-Based Ecosystem Assessments Quantify Species Abundance? Testing Primer Bias and Biomass-Sequence Relationships with an Innovative Metabarcoding Protocol
Elbrecht, Vasco; Leese, Florian

Stable Isotope Turnover and Half-Life in Animal Tissues: A Literature Synthesis
Vander Zanden, M. Jake; Clayton, Murray K.; Moody, Eric K.; Solomon, Christopher T.; Weidel, Brian C.

Population Trend of the World's Monitored Seabirds, 1950-2010
Paleczny, Michelle; Hammill, Edd; Karpouzi, Vasiliki; Pauly, Daniel

Metabarcoding Is Powerful yet Still Blind: A Comparative Analysis of Morphological and Molecular Surveys of Seagrass Communities
Cowart, Dominique A.; Pinheiro, Miguel; Mouchel, Olivier; Maguer, Marion; Grall, Jacques

Use of Droplet Digital PCR for Estimation of Fish Abundance and Biomass in Environmental DNA Surveys
Doi, Hideyuki; Uchii, Kimiko; Takahara, Teruhiko; Matsuhashi, Saeko; Yamanaka, Hiroki

Green Plants in the Red: A Baseline Global Assessment for the IUCN Sampled Red List Index for Plants
Brummitt, Neil A.; Bachman, Steven P.; Griffiths-Lee, Janine; Lutz, Maiko; Moat, Justin F.

Environmental DNA (eDNA) Sampling Improves Occurrence and Detection Estimates of Invasive Burmese Pythons
Hunter, Margaret E.; Oyler-McCance, Sara J.; Dorazio, Robert M.; Fike, Jennifer A.; Smith, Brian J.

Using DNA Metabarcoding to Identify the Floral Composition of Honey: A New Tool for Investigating Honey Bee Foraging Preferences
Hawkins, Jennifer; de Vere, Natasha; Griffith, Adelaide; Ford, Col R.; Allainguillaume, Joel

Highly Overlapping Winter Diet in Two Sympatric Lemming Species Revealed by DNA Metabarcoding
Soininen, Eeva M.; Gauthier, Gilles; Bilodeau, Frederic; Berteaux, Dominique; Gielly, Ludovic

Bacteria Isolated from Bats Inhibit the Growth of Pseudogymnoascus destructans, the Causative Agent of White-Nose Syndrome
Hoyt, Joseph R.; Cheng, Tina L.; Langwig, Kate E.; Hee, Mallory M.; Frick, Winifred F.





The Heterogeneous Dynamics of Economic Complexity
Cristelli, Matthieu; Tacchella, Andrea; Pietronero, Luciano

Changes in Prices After an Excise Tax to Sweetened Sugar Beverages Was Implemented in Mexico: Evidence from Urban Areas
Arantxa Colchero, M.; Carlos Salgado, Juan; Unar-Munguia, Mishel; Molina, Mariana; Ng, Shuwen

The Fishery Performance Indicators: A Management Tool for Triple Bottom Line Outcomes
Anderson, James L.; Anderson, Christopher M.; Chu, Jingjie; Meredith, Jennifer; Asche, Frank

Entrepreneurial Regions: Do Macro-Psychological Cultural Characteristics of Regions Help Solve the "Knowledge Paradox" of Economics?
Obschonka, Martin; Stuetzer, Michael; Gosling, Samuel D.; Rentfrow, Peter J.; Lamb, Michael E.

Revisiting GMOs: Are There Differences in European Consumers' Acceptance and Valuation for Cisgenically vs Transgenically Bred Rice?
Delwaide, Anne-Cecile; Nalley, Lawton L.; Dixon, Bruce L.; Danforth, Diana M.; Nayga, Rodolfo M., Jr.

Determinants of Default in P2P Lending
Serrano-Cinca, Carlos; Gutierrez-Nieto, Begona; Lopez-Palacios, Luz

How Effective Are Biodiversity Conservation Payments in Mexico?
Costedoat, Sebastien; Corbera, Esteve; Ezzine-de-Blas, Driss; Honey-Roses, Jordi; Baylis, Kathy

World Input-Output Network
Cerina, Federica; Zhu, Zhen; Chessa, Alessandro; Riccaboni, Massimo

Measuring the Closeness of Relationships: A Comprehensive Evaluation of the 'Inclusion of the Other in the Self' Scale
Gaechter, Simon; Starmer, Chris; Tufano, Fabio

Naming and Shaming for Conservation: Evidence from the Brazilian Amazon
Cisneros, Elas; Zhou, Sophie Lian; Boerner, Jan



Endocrinology & Metabolism


The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies
Calton, Emily K.; Keane, Kevin N.; Newsholme, Philip; Soares, Mario J.

Inflammatory Cytokines in General and Central Obesity and Modulating Effects of Physical Activity
Schmidt, Frank M.; Weschenfelder, Julia; Sander, Christian; Minkwitz, Juliane; Thormann, Julia

Prevalence of Gestational Diabetes Mellitus and Its Risk Factors in Chinese Pregnant Women: A Prospective Population-Based Study in Tianjin, China
Leng, Junhong; Shao, Ping; Zhang, Cuiping; Tian, Huiguang; Zhang, Fuxia

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone
Xiong, Jinhu; Piemontese, Marilina; Onal, Melda; Campbell, Josh; Goellner, Joseph J.

The Effect of Glucagon-Like Peptide 1 Receptor Agonists on Weight Loss in Type 2 Diabetes: A Systematic Review and Mixed Treatment Comparison Meta-Analysis
Potts, Jessica E.; Gray, Laura J.; Brady, Emer M.; Khunti, Kamlesh; Davies, Melanie J.

Temporal Relationship between Vitamin D Status and Parathyroid Hormone in the United States
Kroll, Martin H.; Bi, Caixia; Garber, Carl C.; Kaufman, Harvey W.; Liu, Dungang

Comparative Efficacy and Safety of Antidiabetic Drug Regimens Added to Metformin Monotherapy in Patients with Type 2 Diabetes: A Network Meta-Analysis
Mearns, Elizabeth S.; Sobieraj, Diana M.; White, C. Michael; Saulsberry, Whitney J.; Kohn, Christine G.

High-Fat Diet-Induced Adiposity, Adipose Inflammation, Hepatic Steatosis and Hyperinsulinemia in Outbred CD-1 Mice
Gao, Mingming; Ma, Yongjie; Liu, Dexi

Associations of Fibroblast Growth Factor-23 with Markers of Inflammation, Insulin Resistance and Obesity in Adults
Hanks, Lynae J.; Casazza, Krista; Judd, Suzanne E.; Jenny, Nancy S.; Gutierrez, Orlando M.

Comparison of Body Mass Index (BMI), Body Adiposity Index (BAI), Waist Circumference (WC), Waist-To-Hip Ratio (WHR) and Waist-To-Height Ratio (WHtR) as Predictors of Cardiovascular Disease Risk Factors in an Adult Population in Singapore
Lam, Benjamin Chih Chiang; Koh, Gerald Choon Huat; Chen, Cynthia; Wong, Michael Tack Keong; Fallows, Stephen J.



Environmental Sciences


Future Coastal Population Growth and Exposure to Sea-Level Rise and Coastal Flooding - A Global Assessment
Neumann, Barbara; Vafeidis, Athanasios T.; Zimmermann, Juliane; Nicholls, Robert J.

Air Pollution in China: Mapping of Concentrations and Sources
Rohde, Robert A.; Muller, Richard A.

Plastic Accumulation in the Mediterranean Sea
Cozar, Andres; Sanz-Martin, Marina; Marti, Elisa; Gonzalez-Gordillo, J. Ignacio; Ubeda, Barbara

The Scientific Consensus on Climate Change as a Gateway Belief: Experimental Evidence
van der Linden, Sander L.; Leiserowitz, Anthony A.; Feinberg, Geoffrey D.; Maibach, Edward W.

The Role of Google Scholar in Evidence Reviews and Its Applicability to Grey Literature Searching
Haddaway, Neal Robert; Collins, Alexandra Mary; Coughlin, Deborah; Kirk, Stuart

Perinatal Outcomes and Unconventional Natural Gas Operations in Southwest Pennsylvania
Stacy, Shaina L.; Brink, LuAnn L.; Larkin, Jacob C.; Sadovsky, Yoel; Goldstein, Bernard D.

Impact of Soil Heavy Metal Pollution on Food Safety in China
Zhang, Xiuying; Zhong, Taiyang; Liu, Lei; Ouyang, Xiaoying

Wasted Food: US Consumers' Reported Awareness, Attitudes, and Behaviors
Neff, Roni A.; Spiker, Marie L.; Truant, Patricia L.

Pathway for Biodegrading Microcystin-YR by Sphingopyxis sp USTB-05
Xu, Huimin; Wang, Huasheng; Xu, Qianqian; Lv, Le; Yin, Chunhua

Transnational Corporations as 'Keystone Actors' in Marine Ecosystems
Osterblom, Henrik; Jouffray, Jean-Baptiste; Folke, Carl; Crona, Beatrice; Troell, Max



Food Science & Technology


Nutritional Evaluation of Australian Microalgae as Potential Human Health Supplements
Kent, Megan; Welladsen, Heather M.; Mangott, Arnold; Li, Yan

Structure-Thermodynamics-Antioxidant Activity Relationships of Selected Natural Phenolic Acids and Derivatives: An Experimental and Theoretical Evaluation
Chen, Yuzhen; Xiao, Huizhi; Zheng, Jie; Liang, Guizhao

Evaluation of Synergistic Antibacterial and Antioxidant Efficacy of Essential Oils of Spices and Herbs in Combination
Bag, Anwesa; Chattopadhyay, Rabi Ranjan

Caramel Color in Soft Drinks and Exposure to 4-Methylimidazole: A Quantitative Risk Assessment
Smith, Tyler J. S.; Wolfson, Julia A.; Jiao, Ding; Crupain, Michael J.; Rangan, Urvashi

Determining Antioxidant Activities of Lactobacilli Cell-Free Supernatants by Cellular Antioxidant Assay: A Comparison with Traditional Methods
Xing, Jiali; Wang, Gang; Zhang, Qiuxiang; Liu, Xiaoming; Gu, Zhennan

Listeria monocytogenes Prevalence and Characteristics in Retail Raw Foods in China
Wu, Shi; Wu, Qingping; Zhang, Jumei; Chen, Moutong; Yan, Ze'an

Regulation of Lipid Droplet Size in Mammary Epithelial Cells by Remodeling of Membrane Lipid Composition-A Potential Mechanism
Cohen, Bat-Chen; Shamay, Avi; Argov-Argaman, Nurit

Identification of Proanthocyanidins from Litchi (Litchi chinensis Sonn.) Pulp by LC-ESI-Q-TOF-MS and Their Antioxidant Activity
Lv, Qiang; Luo, Fenglei; Zhao, Xiaoyong; Liu, YU; Hu, Guibing

A Comparison of Culture- and PCR-Based Methods to Detect Six Major Non-O157 Serogroups of Shiga Toxin-Producing Escherichia coli in Cattle Feces
Noll, Lance W.; Shridhar, Pragathi B.; Dewsbury, Diana M.; Shi, Xiaorong; Cernicchiaro, Natalia

A H-1 NMR Investigation of the Interaction between Phenolic Acids Found in Mango (Manguifera indica cv Ataulfo) and Papaya (Carica papaya cv Maradol) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) Free Radicals
Lopez-Martinez, Luis M.; Santacruz-Ortega, Hisila; Navarro, Rosa-Elena; Sotelo-Mundo, Rogerio R.; Gonzalez-Aguilar, Gustavo A.



Gastroenterology & Hepatology


The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis
Anderson, Emma L.; Howe, Laura D.; Jones, Hayley E.; Higgins, Julian P. T.; Lawlor, Debbie A.

Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease
Machado, Mariana Verdelho; Michelotti, Gregory Alexander; Xie, Guanhua; de Almeida, Thiago Pereira; Boursier, Jerome

Epidemiology of Pediatric Functional Abdominal Pain Disorders: A Meta-Analysis
Korterink, Judith J.; Diederen, Kay; Benninga, Marc A.; Tabbers, Merit M.

Total Hepatitis B Core Antigen Antibody, a Quantitative Non-Invasive Marker of Hepatitis B Virus Induced Liver Disease
Yuan, Quan; Song, Liu-Wei; Cavallone, Daniela; Moriconi, Francesco; Cherubini, Beatrice

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation
Lan, Tian; Kisseleva, Tatiana; Brenner, David A.

Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis
Yang, Jia; Liu, Xing-xing; Fan, Heng; Tang, Qing; Shou, Zhe-Xing

Performance of Serum microRNAs-122,-192 and-21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis
Becker, Philip P.; Rau, Monika; Schmitt, Johannes; Malsch, Carolin; Hammer, Christian

Bifidobacterium longum CCM 7952 Promotes Epithelial Barrier Function and Prevents Acute DSS-Induced Colitis in Strictly Strain-Specific Manner
Srutkova, Dagmar; Schwarzer, Martin; Hudcovic, Tomas; Zakostelska, Zuzana; Drab, Vladimir

Consideration of Viral Resistance for Optimization of Direct Antiviral Therapy of Hepatitis C Virus Genotype 1-Infected Patients
Dietz, Julia; Susser, Simone; Berkowski, Caterina; Perner, Dany; Zeuzem, Stefan

A Real-Time Clinical Endoscopic System for Intraluminal, Multiplexed Imaging of Surface-Enhanced Raman Scattering Nanoparticles
Garai, Ellis; Sensarn, Steven; Zavaleta, Cristina L.; Loewke, Nathan O.; Rogalla, Stephan



Genetics & Heredity


Inexpensive Multiplexed Library Preparation for Megabase-Sized Genomes
Baym, Michael; Kryazhimskiy, Sergey; Lieberman, Tami D.; Chung, Hattie; Desai, Michael M.

Genome-Wide Association Studies of the Human Gut Microbiota
Davenport, Emily R.; Cusanovich, Darren A.; Michelini, Katelyn; Barreiro, Luis B.; Ober, Carole

PON-P2: Prediction Method for Fast and Reliable Identification of Harmful Variants
Niroula, Abhishek; Urolagin, Siddhaling; Vihinen, Mauno

Optimal Ancient DNA Yields from the Inner Ear Part of the Human Petrous Bone
Pinhasi, Ron; Fernandes, Daniel; Sirak, Kendra; Novak, Mario; Connell, Sarah

Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar)
Gutierrez, Alejandro P.; Yanez, Jose M.; Fukui, Steve; Swift, Bruce; Davidson, William S.

Integrating Crop Growth Models with Whole Genome Prediction through Approximate Bayesian Computation
Technow, Frank; Messina, Carlos D.; Totir, L. Radu; Cooper, Mark

The Genetic Structure of Marijuana and Hemp
Sawler, Jason; Stout, Jake M.; Gardner, Kyle M.; Hudson, Darryl; Vidmar, John

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits
Diogo, Dorothee; Bastarache, Lisa; Liao, Katherine P.; Graham, Robert R.; Fulton, Robert S.

A Genetic Porcine Model of Cancer
Schook, Lawrence B.; Collares, Tiago V.; Hu, Wenping; Liang, Ying; Rodrigues, Fernanda M.

Detection and Validation of QTL Affecting Bacterial Cold Water Disease Resistance in Rainbow Trout Using Restriction-Site Associated DNA Sequencing
Palti, Yniv; Vallejo, Roger L.; Gao, Guangtu; Liu, Sixin; Hernandez, Alvaro G.



Geosciences, Multidisciplinary


Optimization of Causative Factors for Landslide Susceptibility Evaluation Using Remote Sensing and GIS Data in Parts of Niigata, Japan
Dou, Jie; Bui, Dieu Tien; Yunus, Ali P.; Jia, Kun; Song, Xuan

Climate Change Forces New Ecological States in Tropical Andean Lakes
Michelutti, Neal; Wolfe, Alexander P.; Cooke, Colin A.; Hobbs, William O.; Vuille, Mathias

Understanding Fossil Phytolith Preservation: The Role of Partial Dissolution in Paleoecology and Archaeology
Cabanes, Dan; Shahack-Gross, Ruth

Palaeoloxodon and Human Interaction: Depositional Setting, Chronology and Archaeology at the Middle Pleistocene Ficoncella Site (Tarquinia, Italy)
Aureli, Daniele; Contardi, Antonio; Giaccio, Biagio; Jicha, Brian; Lemorini, Cristina

Using Lidar Data to Analyse Sinkhole Characteristics Relevant for Understory Vegetation under Forest Cover-Case Study of a High Karst Area in the Dinaric Mountains
Kobal, Milan; Bertoncelj, Irena; Pirotti, Francesco; Dakskobler, Igor; Kutnar, Lado

The Characters of Dry Soil Layer on the Loess Plateau in China and Their Influencing Factors
Yan, Weiming; Deng, Lei; Zhong, Yangquanwei; Shangguan, Zhouping

How Big of an Effect Do Small Dams Have? Using Geomorphological Footprints to Quantify Spatial Impact of Low-Head Dams and Identify Patterns of Across-Dam Variation
Fencl, Jane S.; Mather, Martha E.; Costigan, Katie H.; Daniels, Melinda D.

Magnified Sediment Export of Small Mountainous Rivers in Taiwan: Chain Reactions from Increased Rainfall Intensity under Global Warming
Lee, Tsung-Yu; Huang, Jr-Chuan; Lee, Jun-Yi; Jien, Shih-Hao; Zehetner, Franz

Species-Specific Effects on Throughfall Kinetic Energy in Subtropical Forest Plantations Are Related to Leaf Traits and Tree Architecture
Goebes, Philipp; Bruelheide, Helge; Haerdtle, Werner; Kroeber, Wenzel; Kuehn, Peter

Synchronous Environmental and Cultural Change in the Emergence of Agricultural Economies 10,000 Years Ago in the Levant
Borrell, Ferran; Junno, Aripekka; Anton Barcelo, Joan





Novel Markers to Delineate Murine M1 and M2 Macrophages
Jablonski, Kyle A.; Amici, Stephanie A.; Webb, Lindsay M.; Ruiz-Rosado, Juan de Dios; Popovich, Phillip G.

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters
Miyake, Sachiko; Kim, Sangwan; Suda, Wataru; Oshima, Kenshiro; Nakamura, Masakazu

Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes
Yu, Huifeng; Sui, Yongjun; Wang, Yichuan; Sato, Noriko; Frey, Blake

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes
Gustin, Audrey; Kirchmeyer, Melanie; Koncina, Eric; Felten, Paul; Losciuto, Sophie

Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes
Candon, Sophie; Perez-Arroyo, Alicia; Marquet, Cindy; Valette, Fabrice; Foray, Anne-Perrine

Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation
Earley, Zachary M.; Akhtar, Suhail; Green, Stefan J.; Naqib, Ankur; Khan, Omair

Probiotics Reduce Inflammation in Antiretroviral Treated, HIV-Infected Individuals: Results of the "Probio-HIV" Clinical Trial
d'Ettorre, Gabriella; Ceccarelli, Giancarlo; Giustini, Noemi; Serafino, Sara; Calantone, Nina

Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germany
van der Linden, Mark; Falkenhorst, Gerhard; Perniciaro, Stephanie; Imoehl, Matthias

Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli
Holm, Jacob Bak; Sorobetea, Daniel; Kiilerich, Pia; Ramayo-Caldas, Yuliaxis; Estelle, Jordi

Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps
Itagaki, Kiyoshi; Kaczmarek, Elzbieta; Lee, Yen Ting; Tang, I. Tien; Isal, Burak



Infectious Diseases


Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting
Newman, Lori; Rowley, Jane; Vander Hoorn, Stephen; Wijesooriya, Nalinka Saman; Unemo, Magnus

Global Estimates of Prevalent and Incident Herpes Simplex Virus Type 2 Infections in 2012
Looker, Katharine J.; Magaret, Amalia S.; Turner, Katherine M. E.; Vickerman, Peter; Gottlieb, Sami L.

Estimating Influenza Disease Burden from Population-Based Surveillance Data in the United States
Reed, Carrie; Chaves, Sandra S.; Kirley, Pam Daily; Emerson, Ruth; Aragon, Deborah

Factors Associated with Virological Failure and Suppression after Enhanced Adherence Counselling, in Children, Adolescents and Adults on Antiretroviral Therapy for HIV in Swaziland
Jobanputra, Kiran; Parker, Lucy Anne; Azih, Charles; Okello, Velephi; Maphalala, Gugu

Seroprevalence and Incidence of hepatitis E in Blood Donors in Upper Austria
Fischer, Carina; Hofmann, Martina; Danzer, Martin; Hofer, Katja; Kaar, Jennifer

Whole Genome Sequencing Shows a Low Proportion of Tuberculosis Disease Is Attributable to Known Close Contacts in Rural Malawi
Glynn, Judith R.; Guerra-Assuncao, Jose Afonso; Houben, Rein M. G. J.; Sichali, Lifted; Mzembe, Themba

Clinical and Therapeutic Aspects of Candidemia: A Five Year Single Centre Study
Bassetti, Matteo; Merelli, Maria; Ansaldi, Filippo; de Florentiis, Daniela; Sartor, Assunta

Trends in AIDS Deaths, New Infections and ART Coverage in the Top 30 Countries with the Highest AIDS Mortality Burden; 1990-2013
Granich, Reuben; Gupta, Somya; Hersh, Bradley; Williams, Brian; Montaner, Julio

Knowledge, Beliefs and Practices Regarding Antiretroviral Medications for HIV Prevention: Results from a Survey of Healthcare Providers in New England
Krakower, Douglas S.; Oldenburg, Catherine E.; Mitty, Jennifer A.; Wilson, Ira B.; Kurth, Ann E.

Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012
Looker, Katharine J.; Magaret, Amalia S.; May, Margaret T.; Turner, Katherine M. E.; Vickerman, Peter



Marine & Freshwater Biology


Partitioning the Relative Importance of Phylogeny and Environmental Conditions on Phytoplankton Fatty Acids
Galloway, Aaron W. E.; Winder, Monika

Short-Term Fidelity, Habitat Use and Vertical Movement Behavior of the Black Rockfish Sebastes schlegelii as Determined by Acoustic Telemetry
Zhang, Yingqiu; Xu, Qiang; Alos, Josep; Liu, Hui; Xu, Qinzeng

Human, Oceanographic and Habitat Drivers of Central and Western Pacific Coral Reef Fish Assemblages
Williams, Ivor D.; Baum, Julia K.; Heenan, Adel; Hanson, Katharine M.; Nadon, Marc O.

Ocean Acidification Has Multiple Modes of Action on Bivalve Larvae
Waldbusser, George G.; Hales, Burke; Langdon, Chris J.; Haley, Brian A.; Schrader, Paul

Fukuyoa paulensis gen. et sp nov., a New Genus for the Globular Species of the Dinoflagellate Gambierdiscus (Dinophyceae)
Gomez, Fernando; Qiu, Dajun; Lopes, Rubens M.; Lin, Senjie

Threatened Caribbean Coral Is Able to Mitigate the Adverse Effects of Ocean Acidification on Calcification by Increasing Feeding Rate
Towle, Erica K.; Enochs, Ian C.; Langdon, Chris

A Standardised Vocabulary for Identifying Benthic Biota and Substrata from Underwater Imagery: The CATAMI Classification Scheme
Althaus, Franziska; Hill, Nicole; Ferrari, Renata; Edwards, Luke; Przeslawski, Rachel

The Seascape of Demersal Fish Nursery Areas in the North Mediterranean Sea, a First Step Towards the Implementation of Spatial Planning for Trawl Fisheries
Colloca, Francesco; Garofalo, Germana; Bitetto, Isabella; Facchini, Maria Teresa; Grati, Fabio

Ecological Change, Sliding Baselines and the Importance of Historical Data: Lessons from Combing Observational and Quantitative Data on a Temperate Reef Over 70 Years
Gatti, Giulia; Bianchi, Carlo Nike; Parravicini, Valeriano; Rovere, Alessio; Peirano, Andrea

Towards Automated Annotation of Benthic Survey Images: Variability of Human Experts and Operational Modes of Automation
Beijbom, Oscar; Edmunds, Peter J.; Roelfsema, Chris; Smith, Jennifer; Kline, David I.





Back to Basics - The Influence of DNA Extraction and Primer Choice on Phylogenetic Analysis of Activated Sludge Communities
Albertsen, Mads; Karst, Soren M.; Ziegler, Anja S.; Kirkegaard, Rasmus H.; Nielsen, Per H.

Changes in Gut Microbiota in Rats Fed a High Fat Diet Correlate with Obesity-Associated Metabolic Parameters
Lecomte, Virginie; Kaakoush, Nadeem O.; Maloney, Christopher A.; Raipuria, Mukesh; Huinao, Karina D.

Role of SFP1 in the Regulation of Candida albicans Biofilm Formation
Chen, Hsueh-Fen; Lan, Chung-Yu

The Carbapenem Inactivation Method (CIM), a Simple and Low-Cost Alternative for the Carba NP Test to Assess Phenotypic Carbapenemase Activity in Gram-Negative Rods
van der Zwaluw, Kim; de Haan, Angela; Pluister, Gerlinde N.; Bootsma, Hester J.; de Neeling, Albert J.

Microbial Community Composition and Diversity via 16S rRNA Gene Amplicons: Evaluating the Illumina Platform
Sinclair, Lucas; Osman, Omneya Ahmed; Bertilsson, Stefan; Eiler, Alexander

Effects of Vendor and Genetic Background on the Composition of the Fecal Microbiota of Inbred Mice
Ericsson, Aaron C.; Davis, J. Wade; Spollen, William; Bivens, Nathan; Givan, Scott

Sex, Body Mass Index, and Dietary Fiber Intake Influence the Human Gut Microbiome
Dominianni, Christine; Sinha, Rashmi; Goedert, James J.; Pei, Zhiheng; Yang, Liying

The Effects of Freezing on Faecal Microbiota as Determined Using MiSeq Sequencing and Culture-Based Investigations
Fouhy, Fiona; Deane, Jennifer; Rea, Mary C.; O'Sullivan, Orla; Ross, R. Paul

The Dynamic Distribution of Porcine Microbiota across Different Ages and Gastrointestinal Tract Segments
Zhao, Wenjing; Wang, Yapeng; Liu, Shuyun; Huang, Jiaojiao; Zhai, Zhengxiao

Declining Incidence of Candidemia and the Shifting Epidemiology of Candida Resistance in Two US Metropolitan Areas, 2008-2013: Results from Population-Based Surveillance
Cleveland, Angela Ahlquist; Harrison, Lee H.; Farley, Monica M.; Hollick, Rosemary; Stein, Betsy





Protection of TGF-beta 1 against Neuroinflammation and Neurodegeneration in A beta(1-42)-Induced Alzheimer's Disease Model Rats
Chen, Jia-Hui; Ke, Kai-Fu; Lu, Jian-Hua; Qiu, Yi-Hua; Peng, Yu-Ping

Dynamics and Correlation of Serum Cortisol and Corticosterone under Different Physiological or Stressful Conditions in Mice
Gong, Shuai; Miao, Yi-Long; Jiao, Guang-Zhong; Sun, Ming-Ju; Li, Hong

MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer's Disease
Denk, Johannes; Boelmans, Kai; Siegismund, Christine; Lassner, Dirk; Arlt, Soenke

Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers
Lugli, Giovanni; Cohen, Aaron M.; Bennett, David A.; Shah, Raj C.; Fields, Christopher J.

Brain-Derived Neurotrophic Factor Ameliorates Learning Deficits in a Rat Model of Alzheimer's Disease Induced by A beta 1-42
Zhang, LU; Fang, YU; Lian, Yajun; Chen, Yuan; Wu, Tianwen

Perception of Body Ownership Is Driven by Bayesian Sensory Inference
Samad, Majed; Chung, Albert Jin; Shams, Ladan

The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network
Palhano-Fontes, Fernanda; Andrade, Katia C.; Tofoli, Luis F.; Santos, Antonio C.; Crippa, Jose Alexandre S.

Orthogonalization of Regressors in fMRI Models
Mumford, Jeanette A.; Poline, Jean-Baptiste; Poldrack, Russell A.

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models
Sankaranarayanan, Sethu; Barten, Donna M.; Vana, Laurel; Devidze, Nino; Yang, Ling

Fluorescent-Protein Stabilization and HighResolution Imaging of Cleared, Intact Mouse Brains
Schwarz, Martin K.; Scherbarth, Annemarie; Sprengel, Rolf; Engelhardt, Johann; Theer, Patrick





Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA
Lanman, Richard B.; Mortimer, Stefanie A.; Zill, Oliver A.; Sebisanovic, Dragan; Lopez, Rene

Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers
Carbognin, Luisa; Pilotto, Sara; Milella, Michele; Vaccaro, Vanja; Brunelli, Matteo

PD-L1 and Survival in Solid Tumors: A Meta-Analysis
Wu, Pin; Wu, Dang; Li, Lijun; Chai, Ying; Huang, Jian

PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups
Schmidt, Lars Henning; Kuemmel, Andreas; Goerlich, Dennis; Mohr, Michael; Broeckling, Sebastian

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1
Szulzewsky, Frank; Pelz, Andreas; Feng, Xi; Synowitz, Michael; Markovic, Darko

The Long Noncoding RNA MEG3 Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma
Liu, Jing; Wan, Li; Lu, Kaihua; Sun, Ming; Pan, Xuan

Validation of a Rapid and Sensitive LC-MS/MS Method for Determination of Exemestane and Its Metabolites, 17 beta-Hydroxyexemestane and 17 beta-Hydroxyexemestane-17-O-beta-D-Glucuronide: Application to Human Pharmacokinetics Study
Wang, Ling-zhi; Goh, Sok-Hwei; Wong, Andrea Li-Ann; Thuya, Win-Lwin; Lau, Jie-Ying Amelia

Classification of Circulating Tumor Cells by Epithelial-Mesenchymal Transition Markers
Wu, Shiyang; Liu, Suyan; Liu, Zhiming; Huang, Jiefeng; Pu, Xiaoyu

Lung Cancer Incidence Trends by Gender, Race and Histology in the United States, 1973-2010
Meza, Rafael; Meernik, Clare; Jeon, Jihyoun; Cote, Michele L.

Inducible but Not Constitutive Expression of PD-L1 in Human Melanoma Cells Is Dependent on Activation of NF-kappa B
Gowrishankar, Kavitha; Gunatilake, Dilini; Gallagher, Stuart J.; Tiffen, Jessamy; Rizos, Helen






Prevalence and Associated Factors of Myopia in High-School Students in Beijing
Wu, Li Juan; You, Qi Sheng; Duan, Jia Li; Luo, Yan Xia; Liu, Li Juan

Muller Glia Activation in Response to Inherited Retinal Degeneration Is Highly Varied and Disease-Specific
Hippert, Claire; Graca, Anna B.; Barber, Amanda C.; West, Emma L.; Smith, Alexander J.

Near Work Related Parameters and Myopia in Chinese Children: the Anyang Childhood Eye Study
Li, Shi-Ming; Li, Si-Yuan; Kang, Meng-Tian; Zhou, Yuehua; Liu, Luo-Ru

Study of 27 Aqueous Humor Cytokines in Type 2 Diabetic Patients with or without Macular Edema
Dong, Ning; Xu, Bing; Chu, Liqun; Tang, Xin

Orthokeratology to Control Myopia Progression: A Meta-Analysis
Sun, Yuan; Xu, Fan; Zhang, Ting; Liu, Manli; Wang, Danyang

Repeatability of Foveal Measurements Using Spectralis Optical Coherence Tomography Segmentation Software
Ctori, Irene; Huntjens, Byki

Oxidative Stress Markers Induced by Hyperosmolarity in Primary Human Corneal Epithelial Cells
Deng, Ruzhi; Hua, Xia; Li, Jin; Chi, Wei; Zhang, Zongduan

A Comparison of Some Organizational Characteristics of the Mouse Central Retina and the Human Macula
Volland, Stefanie; Esteve-Rudd, Julian; Hoo, Juyea; Yee, Claudine; Williams, David S.

The Association between Near Work Activities and Myopia in Children-A Systematic Review and Meta-Analysis
Huang, Hsiu-Mei; Chang, Dolly Shuo-Teh; Wu, Pei-Chang

Optic Disc - Fovea Distance, Axial Length and Parapapillary Zones. The Beijing Eye Study 2011
Jonas, Rahul Arvo; Wang, Ya Xing; Yang, Hua; Li, Jian Jun; Xu, Liang





Predomination and New Genotypes of Enterocytozoon bieneusi in Captive Nonhuman Primates in Zoos in China: High Genetic Diversity and Zoonotic Significance
Karim, Md Robiul; Dong, Haiju; Li, Tongyi; Yu, Fuchang; Li, Dezhong

Association between Liver Fluke Infection and Hepatobiliary Pathological Changes: A Systematic Review and Meta-Analysis
Xia, Jing; Jiang, Shi-chen; Peng, Hong-Juan

Identification of Novel Loci Associated with Gastrointestinal Parasite Resistance in a Red Maasai x Dorper Backcross Population
Benavides, Magda Vieira; Sonstegard, Tad S.; Kemp, Stephen; Mugambi, John M.; Gibson, John P.

Exploring the Gastrointestinal "Nemabiome": Deep Amplicon Sequencing to Quantify the Species Composition of Parasitic Nematode Communities
Avramenko, Russell W.; Redman, Elizabeth M.; Lewis, Roy; Yazwinski, Thomas A.; Wasmuth, James D.

Identical Assemblage of Giardia duodenalis in Humans, Animals and Vegetables in an Urban Area in Southern Brazil Indicates a Relationship among Them
Colli, Cristiane Maria; Bezagio, Renata Coltro; Nishi, Leticia; Bignotto, Thais Souto; Ferreira, Erika Cristina

Bats, Trypanosomes, and Triatomines in Ecuador: New Insights into the Diversity, Transmission, and Origins of Trypanosoma cruzi and Chagas Disease
Pinto, C. Miguel; Ocana-Mayorga, Sofia; Tapia, Elicio E.; Lobos, Simon E.; Zurita, Alejandra P.

The Role of Efflux Pumps in Schistosoma mansoni Praziquantel Resistant Phenotype
Pinto-Almeida, Antonio; Mendes, Tiago; Armada, Ana; Belo, Silvana; Carrilho, Emanuel

Plasmodium falciparum Mating Patterns and Mosquito Infectivity of Natural Isolates of Gametocytes
Morlais, Isabelle; Nsango, Sandrine E.; Toussile, Wilson; Abate, Luc; Annan, Zeinab

Genetic Diversity and Host Specificity Varies across Three Genera of Blood Parasites in Ducks of the Pacific Americas Flyway
Reeves, Andrew B.; Smith, Mathew M.; Meixell, Brandt W.; Fleskes, Joseph P.; Ramey, Andrew M.

Giardia duodenalis Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase
Bhargava, Amol; Cotton, James A.; Dixon, Brent R.; Gedamu, Lashitew; Yates, Robin M.



Pharmacology & Pharmacy


Bactericidal Activity of Curcumin I Is Associated with Damaging of Bacterial Membrane
Tyagi, Poonam; Singh, Madhuri; Kumari, Himani; Kumari, Anita; Mukhopadhyay, Kasturi

Study of the Cardiotoxicity of Venenum Bufonis in Rats using an 1H NMR-Based Metabolomics Approach
Dong, Ge; Wei, Dandan; Wang, Junsong; Guo, Pingping; Li, Minghui

Diosmin Protects against Ethanol-Induced Gastric Injury in Rats: Novel Anti-Ulcer Actions
Arab, Hany H.; Salama, Samir A.; Omar, Hany A.; Arafa, El-Shaimaa A.; Maghrabi, Ibrahim A.

Access to Orphan Drugs: A Comprehensive Review of Legislations, Regulations and Policies in 35 Countries
Gammie, Todd; Lu, Christine Y.; Babar, Zaheer Ud-Din

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1
Sun, Grace Y.; Chen, Zihong; Jasmer, Kimberly J.; Chuang, Dennis Y.; Gu, Zezong

Free Radical-Scavenging, Anti-Inflammatory/Anti-Fibrotic and Hepatoprotective Actions of Taurine and Silymarin against CCl4 Induced Rat Liver Damage
Abdel-Moneim, Ashraf M.; Al-Kahtani, Mohammed A.; El-Kersh, Mohamed A.; Al-Omair, Mohammed A.

Regulation of Multidrug Resistance Proteins by Genistein in a Hepatocarcinoma Cell Line: Impact on Sorafenib Cytotoxicity
Pablo Rigalli, Juan; Ciriaci, Nadia; Arias, Agostina; Paula Ceballos, Maria; Maris Villanueva, Silvina Stella

Metamizole-Associated Adverse Events: A Systematic Review and Meta-Analysis
Koetter, Thomas; da Costa, Bruno R.; Faessler, Margrit; Blozik, Eva; Linde, Klaus

Inverse Agonistic Action of 3-Iodothyronamine at the Human Trace Amine-Associated Receptor 5
Dinter, Juliane; Muehlhaus, Jessica; Wienchol, Carolin Leonie; Yi, Chun-Xia; Nuernberg, Daniela

Adverse Effects of Cholinesterase Inhibitors in Dementia, According to the Pharmacovigilance Databases of the United-States and Canada
Ali, Thibault B.; Schleret, Thomas R.; Reilly, Brian M.; Chen, Winston Yuchen; Abagyan, Ruben



Physics, Multidisciplinary


Heterogeneous Coupling between Interdependent Lattices Promotes the Cooperation in the Prisoner's Dilemma Game
Xia, Cheng-yi; Meng, Xiao-Kun; Wang, Zhen

Network Physiology: How Organ Systems Dynamically Interact
Bartsch, Ronny P.; Liu, Kang K. L.; Bashan, Amir; Ivanov, Plamen Ch.

Parameter Estimation of Fractional-Order Chaotic Systems by Using Quantum Parallel Particle Swarm Optimization Algorithm
Huang, YU; Guo, Feng; Li, Yongling; Liu, Yufeng

Guidelines for the Fitting of Anomalous Diffusion Mean Square Displacement Graphs from Single Particle Tracking Experiments
Kepten, Eldad; Weron, Aleksander; Sikora, Grzegorz; Burnecki, Krzysztof; Garini, Yuval

Effect of Heterogeneous Investments on the Evolution of Cooperation in Spatial Public Goods Game
Huang, Keke; Wang, Tao; Cheng, Yuan; Zheng, Xiaoping

A Complex Network Approach to Stylometry
Amancio, Diego Raphael

Visibility Graph Based Time Series Analysis
Stephen, Mutua; Gu, Changgui; Yang, Huijie

Probing the Topological Properties of Complex Networks Modeling Short Written Texts
Amancio, Diego R.

Investigation on Law and Economics Based on Complex Network and Time Series Analysis
Yang, Jian; Qu, Zhao; Chang, Hui

Complex Network Theory Applied to the Growth of Kuala Lumpur's Public Urban Rail Transit Network
Ding, Rui; Ujang, Norsidah; bin Hamid, Hussain; Wu, Jianjun



Plant Sciences


De Novo Assembly and Discovery of Genes That Are Involved in Drought Tolerance in Tibetan Sophora moorcroftiana
Li, Huie; Yao, Weijie; Fu, Yaru; Li, Shaoke; Guo, Qiqiang

Alleviation of Cadmium Toxicity in Brassica juncea L. (Czern. & Coss.) by Calcium Application Involves Various Physiological and Biochemical Strategies
Ahmad, Parvaiz; Sarwat, Maryam; Bhat, Nazir Ahmad; Wani, Mohd Rafiq; Kazi, Alvina Gul

Comprehensive Survey of Genetic Diversity in Chloroplast Genomes and 45S nrDNAs within Panax ginseng Species
Kim, Kyunghee; Lee, Sang-Choon; Lee, Junki; Lee, Hyun Oh; Joh, Ho Jun

Selection of Suitable Reference Genes for qPCR Normalization under Abiotic Stresses and Hormone Stimuli in Carrot Leaves
Tian, Chang; Jiang, Qian; Wang, Feng; Wang, Guang-Long; Xu, Zhi-Sheng

Genome-Wide Association Mapping for Yield and Other Agronomic Traits in an Elite Breeding Population of Tropical Rice (Oryza sativa)
Begum, Hasina; Spindel, Jennifer E.; Lalusin, Antonio; Borromeo, Teresita; Gregorio, Glenn

CRISPR/Cas9-Mediated Genome Editing in Soybean Hairy Roots
Cai, Yupeng; Chen, LI; Liu, Xiujie; Sun, Shi; Wu, Cunxiang

Regulation of Cadmium-Induced Proteomic and Metabolic Changes by 5-Aminolevulinic Acid in Leaves of Brassica napus L.
Ali, Basharat; Gill, Rafaqat A.; Yang, SU; Gill, Muhammad B.; Farooq, Muhammad A.

Plantecophys - An R Package for Analysing and Modelling Leaf Gas Exchange Data
Duursma, Remko A.

ABA Inducible Rice Protein Phosphatase 2C Confers ABA Insensitivity and Abiotic Stress Tolerance in Arabidopsis
Singh, Amarjeet; Jha, Saroj K.; Bagri, Jayram; Pandey, Girdhar K.

Transgenic Citrus Expressing an Arabidopsis NPR1 Gene Exhibit Enhanced Resistance against Huanglongbing (HLB; Citrus Greening)
Dutt, Manjul; Barthe, Gary; Irey, Michael; Grosser, Jude





The Global Burden of Mental, Neurological and Substance Use Disorders: An Analysis from the Global Burden of Disease Study 2010
Whiteford, Harvey A.; Ferrari, Alize J.; Degenhardt, Louisa; Feigin, Valery; Vos, Theo

Internet and Computer-Based Cognitive Behavioral Therapy for Anxiety and Depression in Youth: A Meta-Analysis of Randomized Controlled Outcome Trials
Ebert, David Daniel; Zarski, Anna-Carlotta; Christensen, Helen; Stikkelbroek, Yvonne; Cuijpers, Pim

Assessing the Efficacy of Restricting Access to Barbecue Charcoal for Suicide Prevention in Taiwan: A Community-Based Intervention Trial
Chen, Ying-Yeh; Chen, Feng; Chang, Shu-Sen; Wong, Jacky; Yip, Paul S. F.

Negative Life Events and Attempted Suicide in Rural China
Zhang, Wen-Chao; Jia, Cun-Xian; Zhang, Ji-yu; Wang, Lin-lin; Liu, Xian-Chen

A Meta-Analysis of Risk Factors for Combat-Related PTSD among Military Personnel and Veterans
Xue, Chen; Ge, Yang; Tang, Bihan; Liu, Yuan; Kang, Peng

Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response
Alonso, Pino; Cuadras, Daniel; Gabriels, Loes; Denys, Damiaan; Goodman, Wayne

A Meta-Analysis of Oxidative Stress Markers in Depression
Liu, Tao; Zhong, Shuming; Liao, Xiaoxiao; Chen, Jian; He, Tingting

Single-Item Measurement of Suicidal Behaviors: Validity and Consequences of Misclassification
Millner, Alexander J.; Lee, Michael D.; Nock, Matthew K.

Alcohol-Related Risk of Suicidal Ideation, Suicide Attempt, and Completed Suicide: A Meta-Analysis
Darvishi, Nahid; Farhadi, Mehran; Haghtalab, Tahereh; Poorolajal, Jalal

Does Publication Bias Inflate the Apparent Efficacy of Psychological Treatment for Major Depressive Disorder? A Systematic Review and Meta-Analysis of US National Institutes of Health-Funded Trials
Driessen, Ellen; Hollon, Steven D.; Bockting, Claudi L. H.; Cuijpers, Pim; Turner, Erick H.



Public, Environmental & Occupational Health


Racism as a Determinant of Health: A Systematic Review and Meta-Analysis
Paradies, Yin; Ben, Jehonathan; Denson, Nida; Elias, Amanuel; Priest, Naomi

Vapors Produced by Electronic Cigarettes and E-Juices with Flavorings Induce Toxicity, Oxidative Stress, and Inflammatory Response in Lung Epithelial Cells and in Mouse Lung
Lerner, Chad A.; Sundar, Isaac K.; Yao, Hongwei; Gerloff, Janice; Ossip, Deborah J.

Aetiology-Specific Estimates of the Global and Regional Incidence and Mortality of Diarrhoeal Diseases Commonly Transmitted through Food
Pires, Sara M.; Fischer-Walker, Christa L.; Lanata, Claudio F.; Devleesschauwer, Brecht; Hall, Aron J.

E-Cigarettes and Smoking Cessation: Evidence from a Systematic Review and Meta-Analysis
Rahman, Muhammad Aziz; Hann, Nicholas; Wilson, Andrew; Mnatzaganian, George; Worrall-Carter, Linda

Effect of Restricting Access to Health Care on Health Expenditures among Asylum-Seekers and Refugees: A Quasi-Experimental Study in Germany, 1994-2013
Bozorgmehr, Kayvan; Razum, Oliver

Puffing Topography and Nicotine Intake of Electronic Cigarette Users
Behar, Rachel Z.; Hua, MY; Talbot, Prue

Relationship between Smoking and Obesity: A Cross-Sectional Study of 499,504 Middle-Aged Adults in the UK General Population
Dare, Shadrach; Mackay, Daniel F.; Pell, Jill P.

Exploring the Prevalence of Disrespect and Abuse during Childbirth in Kenya
Abuya, Timothy; Warren, Charlotte E.; Miller, Nora; Njuki, Rebecca; Ndwiga, Charity

Patient and Disease Characteristics Associated with Activation for Self-Management in Patients with Diabetes, Chronic Obstructive Pulmonary Disease, Chronic Heart Failure and Chronic Renal Disease: A Cross-Sectional Survey Study
Bos-Touwen, Irene; Schuurmans, Marieke; Monninkhof, Evelyn M.; Korpershoek, Yvonne; Spruit-Bentvelzen, Lotte

Completeness of Follow-Up Determines Validity of Study Findings: Results of a Prospective Repeated Measures Cohort Study
von Allmen, Regula S.; Weiss, Salome; Tevaearai, Hendrik T.; Kuemmerli, Christoph; Tinner, Christian



Radiology, Nuclear Medicine & Medical Imaging


A New Method of Detecting Pulmonary Nodules with PET/CT Based on an Improved Watershed Algorithm
Zhao, Juanjuan; Ji, Guohua; Qiang, Yan; Han, Xiaohong; Pei, Bo

False Discovery Rates in PET and CT Studies with Texture Features: A Systematic Review
Chalkidou, Anastasia; O'Doherty, Michael J.; Marsden, Paul K.

Quantitative Computed Tomographic Descriptors Associate Tumor Shape Complexity and Intratumor Heterogeneity with Prognosis in Lung Adenocarcinoma
Grove, Olya; Berglund, Anders E.; Schabath, Matthew B.; Aerts, Hugo J. W. L.; Dekker, Andre

MIDA: A Multimodal Imaging-Based Detailed Anatomical Model of the Human Head and Neck
Iacono, Maria Ida; Neufeld, Esra; Akinnagbe, Esther; Bower, Kelsey; Wolf, Johanna

Highest Resolution In Vivo Human Brain MRI Using Prospective Motion Correction
Stucht, Daniel; Danishad, K. Appu; Schulze, Peter; Godenschweger, Frank; Zaitsev, Maxim

Identifying Triple-Negative Breast Cancer Using Background Parenchymal Enhancement Heterogeneity on Dynamic Contrast-Enhanced MRI: A Pilot Radiomics Study
Wang, Jeff; Kato, Fumi; Oyama-Manabe, Noriko; Li, Ruijiang; Cui, YI

Peripheral Nerve Diffusion Tensor Imaging: Assessment of Axon and Myelin Sheath Integrity
Heckel, A.; Weiler, M.; Xia, A.; Ruetters, M.; Pham, M.

18F-FDG PET-Derived Textural Indices Reflect Tissue-Specific Uptake Pattern in Non-Small Cell Lung Cancer
Orlhac, Fanny; Soussan, Michael; Chouahnia, Kader; Martinod, Emmanuel; Buvat, Irene

Predicting Response to Neoadjuvant Chemotherapy with PET Imaging Using Convolutional Neural Networks
Ypsilantis, Petros-Pavlos; Siddique, Musib; Sohn, Hyon-Mok; Davies, Andrew; Cook, Gary

Cerebral Hemodynamic Changes of Mild Traumatic Brain Injury at the Acute Stage
Doshi, Hardik; Wiseman, Natalie; Liu, Jun; Wang, Wentao; Welch, Robert D.



Respiratory System


Exposure to Electronic Cigarettes Impairs Pulmonary Anti-Bacterial and Anti-Viral Defenses in a Mouse Model
Sussan, Thomas E.; Gajghate, Sachin; Thimmulappa, Rajesh K.; Ma, Jinfang; Kim, Jung-Hyun

Asthma and COPD Overlap Syndrome (ACOS): A Systematic Review and Meta Analysis
Alshabanat, A.; Zafari, Z.; Albanyan, O.; Dairi, M.; FitzGerald, J. M.

Mycobacterium tuberculosis Upregulates TNF-alpha Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells
Chen, Wei-Lin; Sheu, Joen-Rong; Chen, Ray-Jade; Hsiao, Shih-Hsin; Hsiao, Che-Jen

Tuberculosis Infection in the United States: Prevalence Estimates from the National Health and Nutrition Examination Survey, 2011-2012
Miramontes, Roque; Hill, Andrew N.; Woodruff, Rachel S. Yelk; Lambert, Lauren A.; Navin, Thomas R.

Three Dimensional Imaging of Paraffin Embedded Human Lung Tissue Samples by Micro-Computed Tomography
Scott, Anna E.; Vasilescu, Dragos M.; Seal, Katherine A. D.; Keyes, Samuel D.; Mavrogordato, Mark N.

Obesity-Hypoventilation Syndrome: Increased Risk of Death over Sleep Apnea Syndrome
Castro-Anon, Olalla; Perez de Llano, Luis A.; De la Fuente Sanchez, Sandra; Golpe, Rafael; Mendez Marote, Lidia

Long-Term Once-Daily Tiotropium Respimat (R) Is Well Tolerated and Maintains Efficacy over 52 Weeks in Patients with Symptomatic Asthma in Japan: A Randomised, Placebo-Controlled Study
Ohta, Ken; Ichinose, Masakazu; Tohda, Yuji; Engel, Michael; Moroni-Zentgraf, Petra

Macrophage Activation in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Schupp, Jonas Christian; Binder, Harald; Jaeger, Benedikt; Cillis, Giuseppe; Zissel, Gernot

Prophylactic Use of Macrolide Antibiotics for the Prevention of Chronic Obstructive Pulmonary Disease Exacerbation: A Meta-Analysis
Ni, Wentao; Shao, Xiaodi; Cai, Xuejiu; Wei, Chuanqi; Cui, Junchang

Risk Factors for Aspiration Pneumonia in Older Adults
Manabe, Toshie; Teramoto, Shinji; Tamiya, Nanako; Okochi, Jiro; Hizawa, Nobuyuki



Sport Sciences


Combined Effects of Time Spent in Physical Activity, Sedentary Behaviors and Sleep on Obesity and Cardio-Metabolic Health Markers: A Novel Compositional Data Analysis Approach
Chastin, Sebastien F. M.; Palarea-Albaladejo, Javier; Dontje, Manon L.; Skelton, Dawn A.

Associations of Objectively Assessed Physical Activity and Sedentary Time with All-Cause Mortality in US Adults: The NHANES Study
Schmid, Daniela; Ricci, Cristian; Leitzmann, Michael F.

Injuries in Runners; A Systematic Review on Risk Factors and Sex Differences
van der Worp, Maarten P.; ten Haaf, Dominique S. M.; van Cingel, Robert; de Wijer, Anton; Nijhuis-van der Sanden, Maria W. G.

Reliability of the Actigraph GT3X+Accelerometer in Adults under Free-Living Conditions
Aadland, Eivind; Ylvisaker, Einar

Step Detection and Activity Recognition Accuracy of Seven Physical Activity Monitors
Storm, Fabio A.; Heller, Ben W.; Mazza, Claudia

High Intensity Interval- vs Moderate Intensity-Training for Improving Cardiometabolic Health in Overweight or Obese Males: A Randomized Controlled Trial
Fisher, Gordon; Brown, Andrew W.; Brown, Michelle M. Bohan; Alcorn, Amy; Noles, Corey

How Does Physical Activity Intervention Improve Self-Esteem and Self-Concept in Children and Adolescents? Evidence from a Meta-Analysis
Liu, Mingli; Wu, Lang; Ming, Qingsen

Correlates of Total Sedentary Time and Screen Time in 9-11 Year-Old Children around the World: The International Study of Childhood Obesity, Lifestyle and the Environment
LeBlanc, Allana G.; Katzmarzyk, Peter T.; Barreira, Tiago V.; Broyles, Stephanie T.; Chaput, Jean-Philippe

Reliability of Health-Related Physical Fitness Tests among Colombian Children and Adolescents: The FUPRECOL Study
Ramirez-Velez, Robinson; Rodrigues-Bezerra, Diogo; Enrique Correa-Bautista, Jorge; Izquierdo, Mikel; Lobelo, Felipe

Assessment of Lower Limb Muscle Strength and Power Using Hand-Held and Fixed Dynamometry: A Reliability and Validity Study
Mentiplay, Benjamin F.; Perraton, Luke G.; Bower, Kelly J.; Adair, Brooke; Pua, Yong-Hao





Systematic Review and Meta-Regression of Factors Affecting Midline Incisional Hernia Rates: Analysis of 14 618 Patients
Bosanquet, David C.; Ansell, James; Abdelrahman, Tarig; Cornish, Julie; Harries, Rhiannon

Risk Factors and Outcomes for Postoperative Delirium after Major Surgery in Elderly Patients
Raats, Jelle W.; van Eijsden, Wilbert A.; Crolla, Rogier M. P. H.; Steyerberg, Ewout W.; van der Laan, Lijckle

Superiority of Minimally Invasive Oesophagectomy in Reducing In-Hospital Mortality of Patients with Resectable Oesophageal Cancer: A Meta-Analysis
Zhou, Can; Zhang, LI; Wang, Hua; Ma, Xiaoxia; Shi, Bohui

Surgical Outcomes of 2041 Consecutive Laparoscopic Gastrectomy Procedures for Gastric Cancer: A Large-Scale Case Control Study
Lin, Jian-Xian; Huang, Chang-Ming; Zheng, Chao-Hui; Li, Ping; Xie, Jian-Wei

Streamlined, Inexpensive 3D Printing of the Brain and Skull
Naftulin, Jason S.; Kimchi, Eyal Y.; Cash, Sydney S.

Risk Factors for Central Lymph Node Metastasis in CN0 Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
Sun, Wei; Lan, Xiabin; Zhang, Hao; Dong, Wenwu; Wang, Zhihong

Intestinal Fatty Acid-Binding Protein as a Diagnostic Marker for Complicated and Uncomplicated Necrotizing Enterocolitis: A Prospective Cohort Study
Schurink, Maarten; Kooi, Elisabeth M. W.; Hulzebos, Christian V.; Kox, Rozemarijn G.; Groen, Henk

Experience in Prehospital Endotracheal Intubation Significantly Influences Mortality of Patients with Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis
Bossers, Sebastiaan M.; Schwarte, Lothar A.; Loer, Stephan A.; Twisk, Jos W. R.; Boer, Christa

Clinical Risk Scoring Models for Prediction of Acute Kidney Injury after Living Donor Liver Transplantation: A Retrospective Observational Study
Park, Mi Hye; Shim, Haeng Seon; Kim, Won Ho; Kim, Hyo-Jin; Kim, Dong Joon

Bariatric Surgery for Type 2 Diabetes Mellitus in Patients with BMI <30 kg/m(2): A Systematic Review and Meta-Analysis
Baskota, Attit; Li, Sheyu; Dhakal, Niharika; Liu, Guanjian; Tian, Haoming



Tropical Medicine


School-Age Children Are a Reservoir of Malaria Infection in Malawi
Walldorf, Jenny A.; Cohee, Lauren M.; Coalson, Jenna E.; Bauleni, Andy; Nkanaunena, Kondwani

Mind the Gap: House Structure and the Risk of Malaria in Uganda
Wanzirah, Humphrey; Tusting, Lucy S.; Arinaitwe, Emmanuel; Katureebe, Agaba; Maxwell, Kilama

Blood-Stage Parasitaemia and Age Determine Plasmodium falciparum and P-vivax Gametocytaemia in Papua New Guinea
Koepfli, Cristian; Robinson, Leanne J.; Rarau, Patricia; Salib, Mary; Sambale, Naomi

Effective Coverage and Systems Effectiveness for Malaria Case Management in Sub-Saharan African Countries
Galactionova, Katya; Tediosi, Fabrizio; de Savigny, Don; Smith, Thomas; Tanner, Marcel

A Cluster Randomised Trial Introducing Rapid Diagnostic Tests into Registered Drug Shops in Uganda: Impact on Appropriate Treatment of Malaria
Mbonye, Anthony K.; Magnussen, Pascal; Lal, Sham; Hansen, Kristian S.; Cundill, Bonnie

Deletion of Plasmodium falciparum Histidine-Rich Protein 2 (pfhrp2) and Histidine-Rich Protein 3 (pfhrp3) Genes in Colombian Parasites
Murillo Solano, Claribel; Okoth, Sheila Akinyi; Abdallah, Joseph F.; Pava, Zuleima; Dorado, Erika

Older Age and Time to Medical Assistance Are Associated with Severity and Mortality of Snakebites in the Brazilian Amazon: A Case-Control Study
Feitosa, Esau L.; Sampaio, Vanderson S.; Salinas, Jorge L.; Queiroz, Amanda M.; da Silva, Iran Mendonca

Low Parasitemia in Submicroscopic Infections Significantly Impacts Malaria Diagnostic Sensitivity in the Highlands of Western Kenya
Lo, Eugenia; Zhou, Guofa; Oo, Winny; Afrane, Yaw; Githeko, Andrew

Hotspots of Malaria Transmission in the Peruvian Amazon: Rapid Assessment through a Parasitological and Serological Survey
Rosas-Aguirre, Angel; Speybroeck, Niko; Llanos-Cuentas, Alejandro; Rosanas-Urgell, Anna; Carrasco-Escobar, Gabriel

Factors Associated with Malaria Parasitemia, Anemia and Serological Responses in a Spectrum of Epidemiological Settings in Uganda
Yeka, Adoke; Nankabirwa, Joaniter; Mpimbaza, Arthur; Kigozi, Ruth; Arinaitwe, Emmanuel



Urology & Nephrology


Meta-Analysis of the Associations of p-Cresyl Sulfate (PCS) and Indoxyl Sulfate (IS) with Cardiovascular Events and All-Cause Mortality in Patients with Chronic Renal Failure
Lin, Cheng-jui; Wu, Vincent; Wu, Pei-Chen; Wu, Chih-Jen

Urinary Biomarkers TIMP-2 and IGFBP7 Early Predict Acute Kidney Injury after Major Surgery
Gocze, Ivan; Koch, Matthias; Renner, Philipp; Zeman, Florian; Graf, Bernhard M.

Increased Urinary Exosomal MicroRNAs in Patients with Systemic Lupus Erythematosus
Perez-Hernandez, Javier; Forner, Maria J.; Pinto, Carolina; Chaves, Felipe J.; Cortes, Raquel

Impact of Compliance with a Care Bundle on Acute Kidney Injury Outcomes: A Prospective Observational Study
Kolhe, Nitin V.; Staples, David; Reilly, Timothy; Merrison, Daniel; McIntyre, Christopher W.

A Pilot Study Identifying a Set of microRNAs As Precise Diagnostic Biomarkers of Acute Kidney Injury
Aguado-Fraile, Elia; Ramos, Edurne; Conde, Elisa; Rodriguez, Macarena; Martin-Gomez, Laura

Nonadherence to Medication Therapy in Haemodialysis Patients: A Systematic Review
Ghimire, Saurav; Castelino, Ronald L.; Lioufas, Nicole M.; Peterson, Gregory M.; Zaidi, Syed Tabish R.

Hypoxia Precondition Promotes Adipose-Derived Mesenchymal Stem Cells Based Repair of Diabetic Erectile Dysfunction via Augmenting Angiogenesis and Neuroprotection
Wang, Xiyou; Liu, Cuilong; Li, Shaodan; Xu, Yong; Chen, Ping

Urinary Volatile Organic Compounds for the Detection of Prostate Cancer
Khalid, Tanzeela; Aggio, Raphael; White, Paul; Costello, Ben De Lacy; Persad, Raj

Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Tubular Epithelial Cell Dedifferentiation and Growth via Hepatocyte Growth Factor Induction
Ju, Guan-Qun; Cheng, Jun; Zhong, Liang; Wu, Shuai; Zou, Xiang-yu

A Drosophila Model Identifies a Critical Role for Zinc in Mineralization for Kidney Stone Disease
Chi, Thomas; Kim, Man Su; Lang, Sven; Bose, Neelanjan; Kahn, Arnold



Veterinary Sciences


Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naive Conventional Neonatal and Weaned Pigs
Thomas, Joseph T.; Chen, QI; Gauger, Phillip C.; Gimenez-Lirola, Luis G.; Sinha, Avanti

Comparative Evaluation of the Vector Competence of Four South American Populations of the Rhipicephalus sanguineus Group for the Bacterium Ehrlichia canis, the Agent of Canine Monocytic Ehrlichiosis
Moraes-Filho, Jonas; Krawczak, Felipe S.; Costa, Francisco B.; Soares, Joao Fabio; Labruna, Marcelo B.

Cross-Sectional Study on Antibiotic Usage in Pigs in Germany
van Rennings, Lisa; von Muenchhausen, Christiane; Ottilie, Henry; Hartmann, Maria; Merle, Roswitha

EquiFACS: The Equine Facial Action Coding System
Wathan, Jen; Burrows, Anne M.; Waller, Bridget M.; McComb, Karen

First Description of a New Disease in Rainbow Trout (Oncorhynchus mykiss (Walbaum)) Similar to Heart and Skeletal Muscle Inflammation (HSMI) and Detection of a Gene Sequence Related to Piscine Orthoreovirus (PRV)
Olsen, Anne Berit; Hjortaas, Monika; Tengs, Torstein; Hellberg, Hege; Johansen, Renate

Impact of Facial Conformation on Canine Health: Brachycephalic Obstructive Airway Syndrome
Packer, Rowena M. A.; Hendricks, Anke; Tivers, Michael S.; Burn, Charlotte C.

Concentration, Size Distribution, and Infectivity of Airborne Particles Carrying Swine Viruses
Alonso, Carmen; Raynor, Peter C.; Davies, Peter R.; Torremorell, Montserrat

Pathogenesis of Primary Foot-and-Mouth Disease Virus Infection in the Nasopharynx of Vaccinated and Non-Vaccinated Cattle
Stenfeldt, Carolina; Eschbaumer, Michael; Pacheco, Juan M.; Rekant, Steven I.; Rodriguez, Luis L.

Impact of Porcine Epidemic Diarrhea on Performance of Growing Pigs
Alvarez, Julio; Sarradell, Javier; Morrison, Robert; Perez, Andres

Changes in the Porcine Intestinal Microbiome in Response to Infection with Salmonella enterica and Lawsonia intracellularis
Borewicz, Klaudyna A.; Kim, Hyeun Bum; Singer, Randall S.; Gebhart, Connie J.; Sreevatsan, Srinand





Host APOBEC3G Protein Inhibits HCV Replication through Direct Binding at NS3
Zhu, Yan-Ping; Peng, Zong-Gen; Wu, Zhou-Yi; Li, Jian-rui; Huang, Meng-Hao

Identification of Transcription Factor AML-1 Binding Site Upstream of Human Cytomegalovirus UL111A Gene
Zheng, Xiaoqun; Gao, Yan; Zhang, QI; Liu, Yanqing; Peng, Ying

Metagenomic Profile of the Viral Communities in Rhipicephalus spp. Ticks from Yunnan, China
Xia, Han; Hu, Cheng; Zhang, Dake; Tang, Shuang; Zhang, Zhong

New Insights into Flavivirus Evolution, Taxonomy and Biogeographic History, Extended by Analysis of Canonical and Alternative Coding Sequences
Moureau, Gregory; Cook, Shelley; Lemey, Philippe; Nougairede, Antoine; Forrester, Naomi L.

CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection
Wollebo, Hassen S.; Bellizzi, Anna; Kaminski, Rafal; Hu, Wenhui; White, Martyn K.

Characteristics and Their Clinical Relevance of Respiratory Syncytial Virus Types and Genotypes Circulating in Northern Italy in Five Consecutive Winter Seasons
Esposito, Susanna; Piralla, Antonio; Zampiero, Alberto; Bianchini, Sonia; Di Pietro, Giada

Genotypic Distribution of Hepatitis C Virus in Thailand and Southeast Asia
Wasitthankasem, Rujipat; Vongpunsawad, Sompong; Siripon, Nipaporn; Suya, Chutima; Chulothok, Phrutsada

Pre-Transplant Plasma Torque Teno Virus Load and Increase Dynamics after Lung Transplantation
Goerzer, Irene; Jaksch, Peter; Kundi, Michael; Seitz, Tamara; Klepetko, Walter

Full-Genome Sequencing as a Basis for Molecular Epidemiology Studies of Bluetongue Virus in India
Maan, Sushila; Maan, Narender S.; Belaganahalli, Manjunatha N.; Rao, Pavuluri Panduranga; Singh, Karam Pal

Persistent Foot-and-Mouth Disease Virus Infection in the Nasopharynx of Cattle; Tissue-Specific Distribution and Local Cytokine Expression
Pacheco, Juan M.; Smoliga, George R.; O'Donnell, Vivian; Brito, Barbara P.; Stenfeldt, Carolina


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