PLOS ONE 2016 Most Impactful

PLOS ONE 2016 Most Impactful

Every year, the team here at PLOS ONE celebrates those studies that have been recognized by the scientific community as the most impactful - through high numbers of views, downloads and citations. These studies reflect the quality and breadth of reach that our authors’ research has. Our commitment at PLOS ONE is to publish all well-performed research and amplify its discoverability so that it reaches communities where it has the most impact. We hope you enjoy this Collection.

We introduce the Collection. FIND OUT MORE >>

Most Impactful




Jump To

Biochemical Research Methods

Biochemistry & Molecular Biology

Biotechnology & Applied Microbiology

Cardiac & Cardiovascular Systems

Cell Biology

Clinical Neurology



Endocrinology & Metabolism

Environmental Sciences

Food Science & Technology

Gastroenterology & Hepatology

Genetics & Heredity

Geosciences, Multidisciplinary


Infectious Diseases

Marine & Freshwater Biology






Pharmacology & Pharmacy

Physics, Multidisciplinary

Plant Sciences


Public, Environmental & Occupational Health

Radiology, Nuclear Medicine & Medical Imaging

Respiratory System

Sport Sciences


Tropical Medicine

Urology & Nephrology

Veterinary Sciences


Biochemical Research Methods


Optimizing Imaging Conditions for Demanding Multi-Color Super Resolution Localization Microscopy
Nahidiazar, Leila; Agronskaia, Alexandra V.; Broertjes, Jorrit; van den Broek, Bram; Jalink, Kees

Super-Resolution Imaging of Molecular Emission Spectra and Single Molecule Spectral Fluctuations
Mlodzianoski, Michael J.; Curthoys, Nikki M.; Gunewardene, Mudalige S.; Carter, Sean; Hess, Samuel T.

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease
Khoonsari, Payam Emami; Haggmark, Anna; Lonnberg, Maria; Mikus, Maria; Kilander, Lena

Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery
Saigusa, Daisuke; Okamura, Yasunobu; Motoike, Ikuko N.; Katoh, Yasutake; Kurosawa, Yasuhiro

SWATH2stats: An R/Bioconductor Package to Process and Convert Quantitative SWATH-MS Proteomics Data for Downstream Analysis Tools
Blattmann, Peter; Heusel, Moritz; Aebersold, Ruedi

Tools for Single-Cell Kinetic Analysis of Virus-Host Interactions
Warrick, Jay W.; Timm, Andrea; Swick, Adam; Yin, John

Technical Advances of the Recombinant Antibody Microarray Technology Platform for Clinical Immunoproteomics
Delfani, Payam; Mellby, Linda Dexlin; Nordstrom, Malin; Holmer, Andreas; Ohlsson, Mattias

Reproducibility of Fluorescent Expression from Engineered Biological Constructs in E-coli
Beal, Jacob; Haddock-Angelli, Traci; Gershater, Markus; De Mora, Kim; Lizarazo, Meagan

A General Method for Targeted Quantitative Cross-Linking Mass Spectrometry
Chavez, Juan D.; Eng, Jimmy K.; Schweppe, Devin K.; Cilia, Michelle; Rivera, Keith

Changes in the Chemical Barrier Composition of Tears in Alzheimer's Disease Reveal Potential Tear Diagnostic Biomarkers
Kallo, Gergo; Emri, Miklos; Varga, Zsofia; Ujhelyi, Bernadett; Tozser, Jozsef



Biochemistry & Molecular Biology


The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression
Geng, Hai-Hua; Li, Rui; Su, Ya-min; Xiao, Jie; Pan, Min

The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression
Yu, Lei; Gong, Xuejun; Sun, Lei; Zhou, Qiying; Lu, Baoling

Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis
Mateen, Somaiya; Moin, Shagufta; Khan, Abdul Qayyum; Zafar, Atif; Fatima, Naureen

SVM-Prot 2016: A Web-Server for Machine Learning Prediction of Protein Functional Families from Sequence Irrespective of Similarity
Li, Ying Hong; Xu, Jing Yu; Tao, Lin; Li, Xiao Feng; Li, Shuang

Oxidative Stress and Metabolic Perturbations in Wooden Breast Disorder in Chickens
Abasht, Behnam; Mutryn, Marie F.; Michalek, Ryan D.; Lee, William R.

Iron and Oxidative Stress in Parkinson's Disease: An Observational Study of Injury Biomarkers
Medeiros, Marcio S.; Schumacher-Schuh, Arthur; Cardoso, Andreia Machado; Bochi, Guilherme Vargas; Baldissarelli, Jucimara

Global DNA Methylation Changes in Nile Tilapia Gonads during High Temperature-Induced Masculinization
Sun, Li-Xue; Wang, Yi-Ya; Zhao, Yan; Wang, Hui; Li, Ning

Kinetics of Thermal Denaturation and Aggregation of Bovine Serum Albumin
Borzova, Vera A.; Markossian, Kira A.; Chebotareva, Natalia A.; Kleymenov, Sergey Yu.; Poliansky, Nikolay B.

Human Gut Bacteria Are Sensitive to Melatonin and Express Endogenous Circadian Rhythmicity
Paulose, Jiffin K.; Wright, John M.; Patel, Akruti G.; Cassone, Vincent M.

Genome Wide Identification and Functional Prediction of Long Non-Coding RNAs Responsive to Sclerotinia sclerotiorum Infection in Brassica napus
Joshi, Raj Kumar; Megha, Swati; Basu, Urmila; Rahman, Muhammad H.; Kav, Nat N. V.



Biotechnology & Applied Microbiology


Distinct Geographical Distribution of the Miscanthus Accessions with Varied Biomass Enzymatic Saccharification
Li, Xukai; Liao, Haofeng; Fan, Chunfen; Hu, Huizhen; Li, Ying

Comparing Apples and Oranges?: Next Generation Sequencing and Its Impact on Microbiome Analysis
Clooney, Adam G.; Fouhy, Fiona; Sleator, Roy D.; Driscoll, Aisling O'; Stanton, Catherine

SARTools: A DESeq2-and EdgeR-Based R Pipeline for Comprehensive Differential Analysis of RNA-Seq Data
Varet, Hugo; Brillet-Gueguen, Loraine; Coppee, Jean-Yves; Dillies, Marie-Agnes

Genome Sequence of the Edible Cultivated Mushroom Lentinula edodes (Shiitake) Reveals Insights into Lignocellulose Degradation
Chen, Lianfu; Gong, Yuhua; Cai, Yingli; Liu, Wei; Zhou, Yan

The Ontology for Biomedical Investigations
Bandrowski, Anita; Brinkman, Ryan; Brochhausen, Mathias; Brush, Matthew H.; Bug, Bill

Promoter Screening from Bacillus subtilis in Various Conditions Hunting for Synthetic Biology and Industrial Applications
Song, Yafeng; Nikoloff, Jonas M.; Fu, Gang; Chen, Jingqi; Li, Qinggang

Evaluation of Nine Somatic Variant Callers for Detection of Somatic Mutations in Exome and Targeted Deep Sequencing Data
Kroigard, Anne Bruun; Thomassen, Mads; Laenkholm, Anne-Vibeke; Kruse, Torben A.; Larsen, Martin Jakob

Selected Schizosaccharomyces pombe Strains Have Characteristics That Are Beneficial for Winemaking
Benito, Angel; Jeffares, Daniel; Palomero, Felipe; Calderon, Fernando; Bai, Feng-Yan

Evolution of E. coli on [U-C-13] Glucose Reveals a Negligible Isotopic Influence on Metabolism and Physiology
Sandberg, Troy E.; Long, Christopher P.; Gonzalez, Jacqueline E.; Feist, Adam M.; Antoniewicz, Maciek R.

SparkBWA: Speeding Up the Alignment of High-Throughput DNA Sequencing Data
Abuin, Jose M.; Pichel, Juan C.; Pena, Tomas F.; Amigo, Jorge



Cardiac & Cardiovascular Systems


Asymmetric and Symmetric Dimethylarginine as Risk Markers for Total Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Studies
Schlesinger, Sabrina; Sonntag, Svenja R.; Lieb, Wolfgang; Maas, Renke

Quality of Vitamin K Antagonist Control and 1-Year Outcomes in Patients with Atrial Fibrillation: A Global Perspective from the GARFIELD-AF Registry
Haas, Sylvia; ten Cate, Hugo; Accetta, Gabriele; Angchaisuksiri, Pantep; Bassand, Jean-Pierre

Long Non-Coding RNA-ROR Mediates the Reprogramming in Cardiac Hypertrophy
Jiang, Feng; Zhou, Xiangyu; Huang, Jing

Identifying the Source of a Humoral Factor of Remote (Pre)Conditioning Cardioprotection
Mastitskaya, Svetlana; Basalay, Marina; Hosford, Patrick S.; Ramage, Andrew G.; Gourine, Andrey

Protective Effect of Irisin on Atherosclerosis via Suppressing Oxidized Low Density Lipoprotein Induced Vascular Inflammation and Endothelial Dysfunction
Zhang, Yuzhu; Mu, Qian; Zhou, Zheng; Song, Haibo; Zhang, Yuan

National Assessment of Statin Therapy in Patients Hospitalized with Acute Myocardial Infarction: Insight from China PEACE-Retrospective AMI Study, 2001, 2006, 2011
Zhang, Lihua; Li, Jing; Li, XI; Nasir, Khurram; Zhang, Haibo

Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery
Emanueli, Costanza; Shearn, Andrew I. U.; Laftah, Abas; Fiorentino, Francesca; Reeves, Barnaby C.

Risk Factors for Acute Kidney Injury after Congenital Cardiac Surgery in Infants and Children: A Retrospective Observational Study
Park, Sun-Kyung; Hur, Min; Kim, EunHee; Kim, Won Ho; Park, Jung Bo

Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes
Joseph, Leroy C.; Barca, Emanuele; Subramanyam, Prakash; Komrowski, Michael; Pajvani, Utpal

Association of Smoking, Alcohol, and Obesity with Cardiovascular Death and Ischemic Stroke in Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study and Cardiovascular Health Study (CHS)
Kwon, Younghoon; Norby, Faye L.; Jensen, Paul N.; Agarwal, Sunil K.; Soliman, Elsayed Z.



Cell Biology


Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance
Lasda, Erika; Parker, Roy

Comparative Study of Injury Models for Studying Muscle Regeneration in Mice
Hardy, David; Besnard, Aurore; Latil, Mathilde; Jouvion, Gregory; Briand, David

Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement
Zhang, Xun E.; Adderley, Shaquria P.; Breslin, Jerome W.

Resveratrol Protects against TNF-alpha-Induced Injury in Human Umbilical Endothelial Cells through Promoting Sirtuin-1-Induced Repression of NF-KB and p38 MAPK
Pan, Wei; Yu, Huizhen; Huang, Shujie; Zhu, Pengli

Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution
Baiocchini, Andrea; Montaldo, Claudia; Conigliaro, Alice; Grimaldi, Alessio; Correani, Virginia

miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis
Disayabutr, Supparerk; Kim, Eun Kyung; Cha, Seung-Ick; Green, Gary; Naikawadi, Ram P.

Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids
Park, Jung-ha; Kotani, Takenori; Konno, Tasuku; Setiawan, Jajar; Kitamura, Yasuaki

Investigation of Content, Stoichiometry and Transfer of miRNA from Human Neural Stem Cell Line Derived Exosomes
Stevanato, Lara; Thanabalasundaram, Lavaniya; Vysokov, Nickolai; Sinden, John D.

AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function
Kang, Sun Woo Sophie; Haydar, Ghada; Taniane, Caitlin; Farrell, Geoffrey; Arias, Irwin M.

Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia
Xin, Ying; Jiang, Xin; Wang, Yishu; Su, Xuejin; Sun, Meiyu



Clinical Neurology


Dysphagia in Acute Stroke: Incidence, Burden and Impact on Clinical Outcome
Arnold, Marcel; Liesirova, Kai; Broeg-Morvay, Anne; Meisterernst, Julia; Schlager, Markus

Predicting Progression from Mild Cognitive Impairment to Alzheimer's Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification
Korolev, Igor O.; Symonds, Laura L.; Bozoki, Andrea C.

Increased Brain-Specific MiR-9 and MiR-124 in the Serum Exosomes of Acute Ischemic Stroke Patients
Ji, Qiuhong; Ji, Yuhua; Peng, Jingwen; Zhou, Xin; Chen, Xinya

Internet-Delivered Cognitive Behavioral Therapy to Treat Insomnia: A Systematic Review and Meta-Analysis
Seyffert, Michael; Lagisetty, Pooja; Landgraf, Jessica; Chopra, Vineet; Pfeiffer, Paul N.

Long-Term Use of Everolimus in Patients with Tuberous Sclerosis Complex: Final Results from the EXIST-1 Study
Franz, David N.; Belousova, Elena; Sparagana, Steven; Bebin, E. Martina; Frost, Michael D.

Long-Term Efficacy, Safety, and Pharmacokinetics of Drisapersen in Duchenne Muscular Dystrophy: Results from an Open-Label Extension Study
Goemans, Nathalie M.; Tulinius, Mar; van den Hauwe, Marleen; Kroksmark, Anna-Karin; Buyse, Gunnar

The Short- and Long-Term Risk of Stroke after Herpes Zoster: A Meta-Analysis
Liu, Xuechun; Guan, Yeming; Hou, Liang; Huang, Haili; Liu, Hongjuan

Increased Intrathecal Immune Activation in Virally Suppressed HIV-1 Infected Patients with Neurocognitive Impairment
Eden, Arvid; Marcotte, Thomas D.; Heaton, Robert K.; Nilsson, Staffan; Zetterberg, Henrik

Hyperthermic Laser Ablation of Recurrent Glioblastoma Leads to Temporary Disruption of the Peritumoral Blood Brain Barrier
Leuthardt, Eric C.; Duan, Chong; Kim, Michael J.; Campian, Jian L.; Kim, Albert H.

Gender as a Modifying Factor Influencing Myotonic Dystrophy Type 1 Phenotype Severity and Mortality: A Nationwide Multiple Databases Cross-Sectional Observational Study
Dogan, Celine; De Antonio, Marie; Hamroun, Dalil; Varet, Hugo; Fabbro, Marianne





Managing Climate Change Refugia for Climate Adaptation
Morelli, Toni Lyn; Daly, Christopher; Dobrowski, Solomon Z.; Dulen, Deanna M.; Ebersole, Joseph L.

What Is Citizen Science? - A Scientometric Meta-Analysis
Kullenberg, Christopher; Kasperowski, Dick

Environmental DNA from Seawater Samples Correlate with Trawl Catches of Subarctic, Deepwater Fishes
Thomsen, Philip Francis; Moller, Peter Rask; Sigsgaard, Eva Egelyng; Knudsen, Steen Wilhelm; Jorgensen, Ole Ankjaer

Food for Pollinators: Quantifying the Nectar and Pollen Resources of Urban Flower Meadows
Hicks, Damien M.; Ouvrard, Pierre; Baldock, Katherine C. R.; Baude, Mathilde; Goddard, Mark A.

Extreme Wildlife Declines and Concurrent Increase in Livestock Numbers in Kenya: What Are the Causes?
Ogutu, Joseph O.; Piepho, Hans-Peter; Said, Mohamed Y.; Ojwang, Gordon O.; Njino, Lucy W.

Environmental DNA as a 'Snapshot' of Fish Distribution: A Case Study of Japanese Jack Mackerel in Maizuru Bay, Sea of Japan
Yamamoto, Satoshi; Minami, Kenji; Fukaya, Keiichi; Takahashi, Kohji; Sawada, Hideki

How Many Kinds of Birds Are There and Why Does It Matter?
Barrowclough, George F.; Cracraft, Joel; Klicka, John; Zink, Robert M.

How Effective Is Road Mitigation at Reducing Road-Kill? A Meta-Analysis
Rytwinski, Trina; Soanes, Kylie; Jaeger, Jochen A. G.; Fahrig, Lenore; Findlay, C. Scott

Diel Surface Temperature Range Scales with Lake Size
Woolway, R. Iestyn; Jones, Ian D.; Maberly, Stephen C.; French, Jon R.; Livingstone, David M.

Incorporating Anthropogenic Influences into Fire Probability Models: Effects of Human Activity and Climate Change on Fire Activity in California
Mann, Michael L.; Batllori, Enric; Moritz, Max A.; Waller, Eric K.; Berck, Peter





On-Farm Diversity and Market Participation Are Positively Associated with Dietary Diversity of Rural Mothers in Southern Benin, West Africa
Bellon, Mauricio R.; Ntandou-Bouzitou, Gervais D.; Caracciolo, Francesco

The Effect of Price and Socio-Economic Level on the Consumption of Sugar-Sweetened Beverages (SSB): The Case of Ecuador
Paraje, Guillermo

The Effect of Information Provision on Public Consensus about Climate Change
Deryugina, Tatyana; Shurchkov, Olga

Trading Off Global Fuel Supply, CO2 Emissions and Sustainable Development
Wagner, Liam; Ross, Ian; Foster, John; Hankamer, Ben

An Exploration of Human Well-Being Bundles as Identifiers of Ecosystem Service Use Patterns
Hamann, Maike; Biggs, Reinette; Reyers, Belinda

SNAP Participants' Eating Patterns over the Benefit Month: A Time Use Perspective
Hamrick, Karen S.; Andrews, Margaret

Gender and the Publication Output of Graduate Students: A Case Study
Pezzoni, Michele; Mairesse, Jacques; Stephan, Paula; Lane, Julia

Power Asymmetries and Punishment in a Prisoner's Dilemma with Variable Cooperative Investment
Bone, Jonathan E.; Wallace, Brian; Bshary, Redouan; Raihani, Nichola J.

Sports and Child Development
Felfe, Christina; Lechner, Michael; Steinmayr, Andreas

Population-Area Relationship for Medieval European Cities
Cesaretti, Rudolf; Lobo, Jose; Bettencourt, Luis M. A.; Ortman, Scott G.; Smith, Michael E.



Endocrinology & Metabolism


The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction
Kang, Yea Eun; Kim, Ji Min; Joung, Kyong Hye; Lee, Ju Hee; You, Bo Ram

Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes
Ho, Jennifer E.; Larson, Martin G.; Ghorbani, Anahita; Cheng, Susan; Chen, Ming-Huei

Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction
Komiya, Chikara; Tsuchiya, Kyoichiro; Shiba, Kumiko; Miyachi, Yasutaka; Furuke, Shunsaku

Benefits and Harms of Sodium-Glucose Co-Transporter 2 Inhibitors in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
Storgaard, Heidi; Gluud, Lise L.; Bennett, Cathy; Grondahl, Magnus F.; Christensen, Mikkel B.

A Comparison between BMI, Waist Circumference, and Waist-To-Height Ratio for Identifying Cardio-Metabolic Risk in Children and Adolescents
Sardinha, Luis B.; Santos, Diana A.; Silva, Analiza M.; Grontved, Anders; Andersen, Lars B.

The Incidence of End-Stage Renal Disease in the Diabetic (Compared to the Non-Diabetic) Population: A Systematic Review
Narres, Maria; Claessen, Heiner; Droste, Sigrid; Kvitkina, Tatjana; Koch, Michael

Low-Dose Bisphenol-A Impairs Adipogenesis and Generates Dysfunctional 3T3-L1 Adipocytes
Ariemma, Fabiana; D'Esposito, Vittoria; Liguoro, Domenico; Oriente, Francesco; Cabaro, Serena

The Effect of Diet and Exercise on Intestinal Integrity and Microbial Diversity in Mice
Campbell, Sara C.; Wisniewski, Paul J.; Noji, Michael; McGuinness, Lora R.; Haeggblom, Max M.

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas
Singhal, Garima; Fisher, Ffolliott Martin; Chee, Melissa J.; Tan, Tze Guan; El Ouaamari, Abdelfattah

Bilirubin Binding to PPAR alpha Inhibits Lipid Accumulation
Stec, David E.; John, Kezia; Trabbic, Christopher J.; Luniwal, Amarjit; Hankins, Michael W.



Environmental Sciences


The Impacts of Dietary Change on Greenhouse Gas Emissions, Land Use, Water Use, and Health: A Systematic Review
Aleksandrowicz, Lukasz; Green, Rosemary; Joy, Edward J. M.; Smith, Pete; Haines, Andy

The Impacts of Oil Palm on Recent Deforestation and Biodiversity Loss
Vijay, Varsha; Pimm, Stuart L.; Jenkins, Clinton N.; Smith, Sharon J.

The Effects of Natural and Anthropogenic Microparticles on Individual Fitness in Daphnia magna
Ogonowski, Martin; Schur, Christoph; Jarsen, Asa; Gorokhova, Elena

The Effectiveness, Costs and Coastal Protection Benefits of Natural and Nature-Based Defences
Narayan, Siddharth; Beck, Michael W.; Reguero, Borja G.; Losada, Inigo J.; van Wesenbeeck, Bregje

Environmental Impacts of the US Health Care System and Effects on Public Health
Eckelman, Matthew J.; Sherman, Jodi

Decreasing Fires in Mediterranean Europe
Turco, Marco; Bedia, Joaquin; Di Liberto, Fabrizio; Fiorucci, Paolo; von Hardenberg, Jost

Changes in the Floating Plastic Pollution of the Mediterranean Sea in Relation to the Distance to Land
Pedrotti, Maria Luiza; Petit, Stephanie; Elineau, Amanda; Bruzaud, Stephane; Crebassa, Jean-Claude

Deep Soil C, N, and P Stocks and Stoichiometry in Response to Land Use Patterns in the Loess Hilly Region of China
Li, Changzhen; Zhao, Luhong; Sun, Pingsheng; Zhao, Fazhu; Kang, DI

Spatial and Temporal Dynamics and Value of Nature-Based Recreation, Estimated via Social Media
Sonter, Laura J.; Watson, Keri B.; Wood, Spencer A.; Ricketts, Taylor H.

Distribution, Fraction, and Ecological Assessment of Heavy Metals in Sediment Plant System in Mangrove Forest, South China Sea
Li, Ruili; Chai, Minwei; Qiu, Guo Yu



Food Science & Technology


Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil
Souza Machado, Bruna Aparecida; Dantas Silva, Rejane Pina; Barreto, Gabriele de Abreu; Costa, Samantha Serra; da Silva, Danielle Figueredo

Antimicrobial Activity and Possible Mechanism of Action of Citral against Cronobacter sakazakii
Shi, Chao; Song, Kaikuo; Zhang, Xiaorong; Sun, YI; Sui, Yue

Yellow Mealworm Protein for Food Purposes - Extraction and Functional Properties
Zhao, Xue; Vazquez-Gutierrez, Jose Luis; Johansson, Daniel P.; Landberg, Rikard; Langton, Maud

Hepatoprotective Effect of Wheat-Based Solid-State Fermented Antrodia cinnamomea in Carbon Tetrachloride-Induced Liver Injury in Rat
Chiu, Huan-Wen; Hua, Kuo-Feng

Effect of Edible and Active Coating (with Rosemary and Oregano Essential Oils) on Beef Characteristics and Consumer Acceptability
Pelaes Vital, Ana Carolina; Guerrero, Ana; Monteschio, Jessica de Oliveira; Valero, Maribel Velandia; Carvalho, Camila Barbosa

Vitamin Variation in Capsicum Spp. Provides Opportunities to Improve Nutritional Value of Human Diets
Kantar, Michael B.; Anderson, Justin E.; Lucht, Sarah A.; Mercer, Kristin; Bernau, Vivian

Rosa canina Extracts Have Antiproliferative and Antioxidant Effects on Caco-2 Human Colon Cancer
Jimenez, Sandra; Gascon, Sonia; Luquin, Asuncion; Laguna, Mariano; Ancin-Azpilicueta, Carmen

Antioxidant and Anti-Inflammatory Activities of Unexplored Brazilian Native Fruits
Infante, Juliana; Rosalen, Pedro Luiz; Lazarini, Josy Goldoni; Franchin, Marcelo; de Alencar, Severino Matias

Comparison of Metabolites Variation and Antiobesity Effects of Fermented versus Nonfermented Mixtures of Cudrania tricuspidata, Lonicera caerulea, and Soybean According to Fermentation In Vitro and In Vivo
Suh, Dong Ho; Jung, Eun Sung; Park, Hye Min; Kim, Seung Hyung; Lee, Sarah

Barriers and Facilitators to Safe Food Handling among Consumers: A Systematic Review and Thematic Synthesis of Qualitative Research Studies
Young, Ian; Waddell, Lisa



Gastroenterology & Hepatology


Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis
Lefebvre, Eric; Moyle, Graeme; Reshef, Ran; Richman, Lee P.; Thompson, Melanie

Hepatoprotective Effect and Synergism of Bisdemethoycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice
Kim, Sung-Bae; Kang, Ok-Hwa; Lee, Young-Seob; Han, Sin-Hee; Ahn, Young-Sup

Systematic Review: Adverse Events of Fecal Microbiota Transplantation
Wang, Sinan; Xu, Mengque; Wang, Weiqiang; Cao, Xiaocang; Piao, Meiyu

Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease
Mouzaki, Marialena; Wang, Alice Y.; Bandsma, Robert; Comelli, Elena M.; Arendt, Bianca M.

Efficacy and Safety of Direct Acting Antivirals in Kidney Transplant Recipients with Chronic Hepatitis C Virus Infection
Lin, Ming V.; Sise, Meghan E.; Pavlakis, Martha; Amundsen, Beth M.; Chute, Donald

Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg plus Chronic Hepatitis B Infection
Al-Mahtab, Mamun; Bazinet, Michel; Vaillant, Andrew

Efficacy and Safety of Beclomethasone Dipropionate versus 5-Aminosalicylic Acid in the Treatment of Ulcerative Colitis: A Systematic Review and Meta-Analysis
Zhao, Xin; Li, Nan; Ren, Yiming; Ma, Tao; Wang, Chunli

Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice
Dziarski, Roman; Park, Shin Yong; Kashyap, Des Raj; Dowd, Scot E.; Gupta, Dipika

Geno2pheno([HCV]) - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents
Kalaghatgi, Prabhav; Sikorski, Anna Maria; Knops, Elena; Rupp, Daniel; Sierra, Saleta

Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials
Lu, Muhan; Yu, Shan; Deng, Jiaqi; Yan, Qiong; Yang, Chun



Genetics & Heredity


Mutation Detection in Patients with Retinal Dystrophies Using Targeted Next Generation Sequencing
Weisschuh, Nicole; Mayer, Anja K.; Strom, Tim M.; Kohl, Susanne; Gloeckle, Nicola

Selecting Superior De Novo Transcriptome Assemblies: Lessons Learned by Leveraging the Best Plant Genome
Honaas, Loren A.; Wafula, Eric K.; Wickett, Norman J.; Der, Joshua P.; Zhang, Yeting

Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling
Wen, Ya; Alshikho, Mohamad J.; Herbert, Martha R.

A First Insight into the Genome of the Filter-Feeder Mussel Mytilus galloprovincialis
Murgarella, Maria; Puiu, Daniela; Novoa, Beatriz; Figueras, Antonio; Posada, David

Genome Wide Association Study of Seedling and Adult Plant Leaf Rust Resistance in Elite Spring Wheat Breeding Lines
Gao, Liangliang; Turner, M. Kathryn; Chao, Shiaoman; Kolmer, James; Anderson, James A.

Mapping QTLs for Salt Tolerance in Rice (Oryza sativa L.) by Bulked Segregant Analysis of Recombinant Inbred Lines Using 50K SNP Chip
Tiwari, Sushma; Sl, Krishnamurthy; Kumar, Vinod; Singh, Balwant; Rao, A. R.

Genome-Assisted Prediction of Quantitative Traits Using the R Package sommer
Covarrubias-Pazaran, Giovanny

A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits
Volkov, Petr; Olsson, Anders H.; Gillberg, Linn; Jorgensen, Sine W.; Brons, Charlotte

Rapid Identification of Candidate Genes for Seed Weight Using the SLAF-Seq Method in Brassica napus
Geng, Xinxin; Jiang, ChengHong; Yang, Jie; Wang, Lijun; Wu, Xiaoming

Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci
Karch, Celeste M.; Ezerskiy, Lubov A.; Bertelsen, Sarah; Goate, Alison M.



Geosciences, Multidisciplinary


Climate Change Impacts on the Upper Indus Hydrology: Sources, Shifts and Extremes
Lutz, A. F.; Immerzeel, W. W.; Kraaijenbrink, P. D. A.; Shrestha, A. B.; Bierkens, M. F. P.

Collagen Fingerprinting: A New Screening Technique for Radiocarbon Dating Ancient Bone
Harvey, Virginia L.; Egerton, Victoria M.; Chamberlain, Andrew T.; Manning, Phillip L.; Buckley, Michael

Phenotypic Variability in the Coccolithophore Emiliania huxleyi
Blanco-Ameijeiras, Sonia; Lebrato, Mario; Stoll, Heather M.; Iglesias-Rodriguez, Debora; Mueller, Marius N.

Large Scale Anthropogenic Reduction of Forest Cover in Last Glacial Maximum Europe
Kaplan, Jed O.; Pfeiffer, Mirjam; Kolen, Jan C. A.; Davis, Basil A. S.

Towards an Accurate and Precise Chronology for the Colonization of Australia: The Example of Riwi, Kimberley, Western Australia
Wood, Rachel; Jacobs, Zenobia; VanNieuwenhuyse, Dorcas; Balme, Jane; O'Connor, Sue

The Blurred Line between Form and Process: A Comparison of Stream Channel Classification Frameworks
Kasprak, Alan; Hough-Snee, Nate; Beechie, Tim; Bouwes, Nicolaas; Brierley, Gary

Continental Island Formation and the Archaeology of Defaunation on Zanzibar, Eastern Africa
Prendergast, Mary E.; Rouby, Helene; Punnwong, Paramita; Marchant, Robert; Crowther, Alison

The Acheulian and Early Middle Paleolithic in Latium (Italy): Stability and Innovation
Villa, Paola; Soriano, Sylvain; Grun, Rainer; Marra, Fabrizio; Nomade, Sebastien

Land Use Affects Carbon Sources to the Pelagic Food Web in a Small Boreal Lake
Rinta, Paivi; van Hardenbroek, Maarten; Jones, Roger I.; Kankaala, Paula; Rey, Fabian

Statistical Analysis of the Effectiveness of Seawalls and Coastal Forests in Mitigating Tsunami Impacts in Iwate and Miyagi Prefectures
Nateghi, Roshanak; Bricker, Jeremy D.; Guikema, Seth D.; Bessho, Akane





A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues
Yu, Yen-Rei A.; O'Koren, Emily G.; Hotten, Danielle F.; Kan, Matthew J.; Kopin, David

Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy
Grund, Birgit; Baker, Jason V.; Deeks, Steven G.; Wolfson, Julian; Wentworth, Deborah

Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology
Selby, Mark J.; Engelhardt, John J.; Johnston, Robert J.; Lu, Li-Sheng; Han, Minhua

Control of the Inflammatory Macrophage Transcriptional Signature by miR-155
Jablonski, Kyle A.; Gaudet, Andrew D.; Amici, Stephanie A.; Popovich, Phillip G.; Guerau-de-Arellano, Mireia

Influenza Seasonality in the Tropics and Subtropics - When to Vaccinate?
Hirve, Siddhivinayak; Newman, Laura P.; Paget, John; Azziz-Baumgartner, Eduardo; Fitzner, Julia

Predominant Bacteria Detected from the Middle Ear Fluid of Children Experiencing Otitis Media: A Systematic Review
Ngo, Chinh C.; Massa, Helen M.; Thornton, Ruth B.; Cripps, Allan W.

The Role of Nitric Oxide and Reactive Oxygen Species in the Killing of Leishmania braziliensis by Monocytes from Patients with Cutaneous Leishmaniasis
Carneiro, Pedro Paulo; Conceicao, Jacilara; Macedo, Michael; Magalhaes, Viviane; Carvalho, Edgar M.

HLA-F and MHC-I Open Conformers Bind Natural Killer Cell Ig-Like Receptor KIR3DS1
Burian, Aura; Wang, Kevin L.; Finton, Kathryn A. K.; Lee, NI; Ishitani, Akiko

Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung
De Grove, Katrien C.; Provoost, Sharen; Verhamme, Fien M.; Bracke, Ken R.; Joos, Guy F.

Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo
Zhang, Michael; Hutter, Gregor; Kahn, Suzana A.; Azad, Tej D.; Gholamin, Sharareh



Infectious Diseases


Prevalence of mcr-1 in E. coli from Livestock and Food in Germany, 2010-2015
Irrgang, Alexandra; Roschanski, Nicole; Tenhagen, Bernd-Alois; Grobbel, Mirjam; Skladnikiewicz-Ziemer, Tanja

Empiric Piperacillin-Tazobactam versus Carbapenems in the Treatment of Bacteraemia Due to Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae
Ng, Tat Ming; Khong, Wendy X.; Harris, Patrick N. A.; De, Partha P.; Chow, Angela

Dual Therapy Treatment Strategies for the Management of Patients Infected with HIV: A Systematic Review of Current Evidence in ARV-Naive or ARV-Experienced, Virologically Suppressed Patients
Baril, Jean-Guy; Angel, Jonathan B.; Gill, M. John; Gathe, Joseph; Cahn, Pedro

Recent Transmission of Tuberculosis - United States, 2011-2014
Yuen, Courtney M.; Kammerer, J. Steve; Marks, Kala; Navin, Thomas R.; France, Anne Marie

Pro-Inflammatory Markers in Relation to Cardiovascular Disease in HIV Infection. A Systematic Review
Vos, Alinda G.; Idris, Nikmah S.; Barth, Roos E.; Klipstein-Grobusch, Kerstin; Grobbee, Diederick E.

Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa
Nel, Annalene; Bekker, Linda-Gail; Bukusi, Elizabeth; Hellstroem, Elizabeth; Kotze, Philip

Syphilis Trends among Men Who Have Sex with Men in the United States and Western Europe: A Systematic Review of Trend Studies Published between 2004 and 2015
Abara, Winston E.; Hess, Kristen L.; Fanfair, Robyn Neblett; Bernstein, Kyle T.; Paz-Bailey, Gabriela

Economic Cost of Campylobacter, Norovirus and Rotavirus Disease in the United Kingdom
Tam, Clarence C.; O'Brien, Sarah J.

A Meta-Analysis of the Metabolic Syndrome Prevalence in the Global HIV-Infected Population
Nguyen, Kim A.; Peer, Nasheeta; Mills, Edward J.; Kengne, Andre P.

Single Low Dose Primaquine (0.25mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects
Bancone, Germana; Chowwiwat, Nongnud; Somsakchaicharoen, Raweewan; Poodpanya, Lalita; Moo, Paw Khu



Marine & Freshwater Biology


Seagrass Ecosystem Services and Their Variability across Genera and Geographical Regions
Nordlund, Lina Mtwana; Koch, Evamaria W.; Barbier, Edward B.; Creed, Joel C.

Ocean Acidification Effects on Atlantic Cod Larval Survival and Recruitment to the Fished Population
Stiasny, Martina H.; Mittermayer, Felix H.; Sswat, Michael; Voss, Ruediger; Jutfelt, Fredrik

Influence of Environmental Variables on Gambierdiscus spp. (Dinophyceae) Growth and Distribution
Xu, Yixiao; Richlen, Mindy L.; Liefer, Justin D.; Robertson, Alison; Kulis, David

Relative Contributions of Various Cellular Mechanisms to Loss of Algae during Cnidarian Bleaching
Bieri, Tamaki; Onishi, Masayuki; Xiang, Tingting; Grossman, Arthur R.; Pringle, John R.

Reef Fish Community Biomass and Trophic Structure Changes across Shallow to Upper-Mesophotic Reefs in the Mesoamerican Barrier Reef, Caribbean
Andradi-Brown, Dominic A.; Gress, Erika; Wright, Georgina; Exton, Dan A.; Rogers, Alex D.

Choose Your Weaponry: Selective Storage of a Single Toxic Compound, Latrunculin A, by Closely Related Nudibranch Molluscs
Cheney, Karen L.; White, Andrew; Mudianta, I. Wayan; Winters, Anne E.; Quezada, Michelle

Year-Long Monitoring of Physico-Chemical and Biological Variables Provide a Comparative Baseline of Coral Reef Functioning in the Central Red Sea
Roik, Anna; Rothig, Till; Roder, Cornelia; Ziegler, Maren; Kremb, Stephan G.

Macroalgal Morphogenesis Induced by Waterborne Compounds and Bacteria in Coastal Seawater
Grueneberg, Jan; Engelen, Aschwin H.; Costa, Rodrigo; Wichard, Thomas

Sediment Properties as Important Predictors of Carbon Storage in Zostera marina Meadows: A Comparison of Four European Areas
Dahl, Martin; Deyanova, Diana; Gutschow, Silvia; Asplund, Maria E.; Lyimo, Liberatus D.

Early Mode of Life and Hatchling Size in Cephalopod Molluscs: Influence on the Species Distributional Ranges
Villanueva, Roger; Vidal, Erica A. G.; Fernandez-Alvarez, Fernando A.; Nabhitabhata, Jaruwat





Intestinal Microbiota Is Influenced by Gender and Body Mass Index
Haro, Carmen; Rangel-Zuniga, Oriol A.; Alcala-Diaz, Juan F.; Gomez-Delgado, Francisco; Perez-Martinez, Pablo

Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota
Martin, Rocio; Makino, Hiroshi; Yavuz, Aysun Cetinyurek; Ben-Amor, Kaouther; Roelofs, Mieke

Gardnerella vaginalis Subgroups Defined by cpn60 Sequencing and Sialidase Activity in Isolates from Canada, Belgium and Kenya
Schellenberg, John J.; Jayaprakash, Teenus Paramel; Gamage, Niradha Withana; Patterson, Mo H.; Vaneechoutte, Mario

The Salmonella In Silico Typing Resource (SISTR): An Open Web-Accessible Tool for Rapidly Typing and Subtyping Draft Salmonella Genome Assemblies
Yoshida, Catherine E.; Kruczkiewicz, Peter; Laing, Chad R.; Lingohr, Erika J.; Gannon, Victor P. J.

Genomic and Genetic Diversity within the Pseudomonas fluorescens Complex
Garrido-Sanz, Daniel; Meier-Kolthoff, Jan P.; Goeker, Markus; Martin, Marta; Rivilla, Rafael

Microbes on a Bottle: Substrate, Season and Geography Influence Community Composition of Microbes Colonizing Marine Plastic Debris
Oberbeckmann, Sonja; Osborn, A. Mark; Duhaime, Melissa B.

Gut Microbiome Developmental Patterns in Early Life of Preterm Infants: Impacts of Feeding and Gender
Cong, Xiaomei; Xu, Wanli; Janton, Susan; Henderson, Wendy A.; Matson, Adam

Characterization of the Gut Microbial Community of Obese Patients Following a Weight-Loss Intervention Using Whole Metagenome Shotgun Sequencing
Louis, Sandrine; Tappu, Rewati-Mukund; Damms-Machado, Antje; Huson, Daniel H.; Bischoff, Stephan C.

Epidemiology and Microbiologic Characterization of Nosocomial Candidemia from a Brazilian National Surveillance Program
Doi, Andre Mario; Campos Pignatari, Antonio Carlos; Edmond, Michael B.; Marra, Alexandre Rodrigues; Aranha Camargo, Luis Fernando

Changes in Colonic Bile Acid Composition following Fecal Microbiota Transplantation Are Sufficient to Control Clostridium difficile Germination and Growth
Weingarden, Alexa R.; Dosa, Peter I.; DeWinter, Erin; Steer, Clifford J.; Shaughnessy, Megan K.





Toward a Differential Diagnosis of Hidden Hearing Loss in Humans
Liberman, M. Charles; Epstein, Michael J.; Cleveland, Sandra S.; Wang, Haobing; Maison, Stephane F.

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip
Herland, Anna; van der Meer, Andries D.; Fitzgerald, Edward A.; Park, Tae-Eun; Sleeboom, Jelle J. F.

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes
Raja, Waseem K.; Mungenast, Alison E.; Lin, Yuan-Ta; Ko, Tak; Abdurrob, Fatema

Higher Dimensional Meta-State Analysis Reveals Reduced Resting fMRI Connectivity Dynamism in Schizophrenia Patients
Miller, Robyn L.; Yaesoubi, Maziar; Turner, Jessica A.; Mathalon, Daniel; Preda, Adrian

Cross-Modal and Intra-Modal Characteristics of Visual Function and Speech Perception Performance in Postlingually Deafened, Cochlear Implant Users
Kim, Min-Beom; Shim, Hyun-Yong; Jin, Sun Hwa; Kang, Soojin; Woo, Jihwan

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release
Alexandrou, Aristos J.; Brown, Adam R.; Chapman, Mark L.; Estacion, Mark; Turner, Jamie

A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice
Wolf, Andrea; Bauer, Bjoern; Abner, Erin L.; Ashkenazy-Frolinger, Tal; Hartz, Anika M. S.

The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis
Dinoff, Adam; Herrmann, Nathan; Swardfager, Walter; Liu, Celina S.; Sherman, Chelsea

Representing Representation: Integration between the Temporal Lobe and the Posterior Cingulate Influences the Content and Form of Spontaneous Thought
Smallwood, Jonathan; Karapanagiotidis, Theodoros; Ruby, Florence; Medea, Barbara; De Caso, Irene

Accuracy and Reliability of the Kinect Version 2 for Clinical Measurement of Motor Function
Otte, Karen; Kayser, Bastian; Mansow-Model, Sebastian; Verrel, Julius; Paul, Friedemann





Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection
Lehmann, Brian D.; Jovanovic, Bojana; Chen, Xi; Estrada, Monica V.; Johnson, Kimberly N.

Adverse Events Associated with Immune Checkpoint Blockade in Patients with Cancer: A Systematic Review of Case Reports
Abdel-Wahab, Noha; Shah, Mohsin; Suarez-Almazor, Maria E.

Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes
Berrondo, Claudia; Flax, Jonathan; Kucherov, Victor; Siebert, Aisha; Osinski, Thomas

Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model
Yamamoto, Mako; Zhao, Ming; Hiroshima, Yukihiko; Zhang, Yong; Shurell, Elizabeth

The lncRNA PVT1 Contributes to the Cervical Cancer Phenotype and Associates with Poor Patient Prognosis
Iden, Marissa; Fye, Samantha; Li, Keguo; Chowdhury, Tamjid; Ramchandran, Ramani

Aspirin in the Treatment of Cancer: Reductions in Metastatic Spread and in Mortality: A Systematic Review and Meta-Analyses of Published Studies
Elwood, Peter C.; Morgan, Gareth; Pickering, Janet E.; Galante, Julieta; Weightman, Alison L.

Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy
Young, Kristina H.; Baird, Jason R.; Savage, Talicia; Cottam, Benjamin; Friedman, David

Diagnostic Value of Serum miR-182, miR-183, miR-210, and miR-126 Levels in Patients with Early-Stage Non-Small Cell Lung Cancer
Zhu, Wangyu; Zhou, Kaiyu; Zha, Yao; Chen, Dongdong; He, Jianying

ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer
Yoshida, Takeshi; Song, Lanxi; Bai, Yun; Kinose, Fumi; Li, Jiannong

Circulating Tumor Cells Identify Early Recurrence in Patients with Non-Small Cell Lung Cancer Undergoing Radical Resection
Bayarri-Lara, Clara; Ortega, Francisco G.; Ladron de Guevara, Antonio Cueto; Puche, Jose L.; Ruiz Zafra, Javier





Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using Optical Coherence Tomography-Based Microangiography
Bojikian, Karine D.; Chen, Chieh-Li; Wen, Joanne C.; Zhang, Qinqin; Xin, Chen

Long Non-Coding RNA MALAT1 Mediates Transforming Growth Factor Beta1-Induced Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells
Yang, Shuai; Yao, Haipei; Li, Min; Li, Hui; Wang, Fang

Measurement of Outflow Facility Using iPerfusion
Sherwood, Joseph M.; Reina-Torres, Ester; Bertrand, Jacques A.; Rowe, Barnaby; Overby, Darryl R.

Number of People Blind or Visually Impaired by Glaucoma Worldwide and in World Regions 1990-2010: A Meta-Analysis
Bourne, Rupert R. A.; Taylor, Hugh R.; Flaxman, Seth R.; Keeffe, Jill; Leasher, Janet

Neurodevelopmental Outcomes in Infants with Retinopathy of Prematurity and Bevacizumab Treatment
Lien, Reyin; Yu, Mu-Hsien; Hsu, Kuang-Hung; Liao, Pei-Ju; Chen, Yen-Po

Choroidal Vascularity Index (CVI) - A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis?
Agrawal, Rupesh; Salman, Mohammed; Tan, Kara-Anne; Karampelas, Michael; Sim, Dawn A.

Intrasession and Between-Visit Variability of Sector Peripapillary Angioflow Vessel Density Values Measured with the Angiovue Optical Coherence Tomograph in Different Retinal Layers in Ocular Hypertension and Glaucoma
Hollo, Gabor

Intra-Arterial Chemotherapy (Ophthalmic Artery Chemosurgery) for Group D Retinoblastoma
Abramson, David H.; Daniels, Anthony B.; Marr, Brian P.; Francis, Jasmine H.; Brodie, Scott E.

Ocular Blood Flow Measurements in Healthy White Subjects Using Laser Speckle Flowgraphy
Luft, Nikolaus; Wozniak, Piotr A.; Aschinger, Gerold C.; Fondi, Klemens; Bata, Ahmed M.

Impact of a Glaucoma Severity Index on Results of Trabectome Surgery: Larger Pressure Reduction in More Severe Glaucoma
Loewen, Ralitsa T.; Roy, Pritha; Parikh, Hardik A.; Dang, Yalong; Schuman, Joel S.





Mitochondrial Genome Sequences and Structures Aid in the Resolution of Piroplasmida phylogeny
Schreeg, Megan E.; Marr, Henry S.; Tarigo, Jaime L.; Cohn, Leah A.; Bird, David M.

Cryptosporidium proliferans n. sp (Apicomplexa: Cryptosporidiidae): Molecular and Biological Evidence of Cryptic Species within Gastric Cryptosporidium of Mammals
Kvac, Martin; Havrdova, Nikola; Hlaskova, Lenka; Dankova, Tereza; Kandera, Jiri

Predominance of Blastocystis sp Infection among School Children in Peninsular Malaysia
Nithyamathi, Kalimuthu; Chandramathi, Samudi; Kumar, Suresh

Zoonotic Cryptosporidium Species in Animals Inhabiting Sydney Water Catchments
Zahedi, Alireza; Monis, Paul; Aucote, Sarah; King, Brendon; Paparini, Andrea

Investigating the Determinants of Toxoplasma gondii Prevalence in Meat: A Systematic Review and Meta-Regression
Belluco, Simone; Mancin, Marzia; Conficoni, Daniele; Simonato, Giulia; Pietrobelli, Mario

Canine-Based Strategies for Prevention and Control of Visceral Leishmaniasis in Brazil
Seva, Anaia P.; Ovallos, Fredy G.; Amaku, Marcus; Carrillo, Eugenia; Moreno, Javier

The Early Worm Catches the Bird? Productivity and Patterns of Trichobilharzia szidati Cercarial Emission from Lymnaea stagnalis
Soldanova, Miroslava; Selbach, Christian; Sures, Bernd

A New High-Throughput Approach to Genotype Ancient Human Gastrointestinal Parasites
Cote, Nathalie M. L.; Daligault, Julien; Pruvost, Melanie; Bennett, E. Andrew; Gorge, Olivier

First Report of the Human-Pathogenic Enterocytozoon bieneusi from Red-Bellied Tree Squirrels (Callosciurus erythraeus) in Sichuan, China
Deng, Lei; Li, WEI; Yu, Xingming; Gong, Chao; Liu, Xuehan

Experimental Toxoplasmosis in Rats Induced Orally with Eleven Strains of Toxoplasma gondii of Seven Genotypes: Tissue Tropism, Tissue Cyst Size, Neural Lesions, Tissue Cyst Rupture without Reactivation, and Ocular Lesions
Dubey, Jitender P.; Ferreira, Leandra R.; Alsaad, Mohammad; Verma, Shiv K.; Alves, Derron A.



Pharmacology & Pharmacy


When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis
Scannell, Jack W.; Bosley, Jim

The Comparison of MTT and CVS Assays for the Assessment of Anticancer Agent Interactions
Sliwka, Lidia; Wiktorska, Katarzyna; Suchocki, Piotr; Milczarek, Malgorzata; Mielczarek, Szymon

Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO-cGMP -PKG-K(ATP)Channel Signaling Pathway
Manchope, Marilia F.; Calixto-Campos, Cassia; Coelho-Silva, Leticia; Zarpelon, Ana C.; Pinho-Ribeiro, Felipe A.

Tangeretin Alleviates Cisplatin-Induced Acute Hepatic Injury in Rats: Targeting MAPKs and Apoptosis
Omar, Hany A.; Mohamed, Wafaa R.; Arab, Hany H.; Arafa, El-Shaimaa A.

Development of a Larvicidal Nanoemulsion with Pterodon emarginatus Vogel Oil
Oliveira, Anna E. M. F. M.; Duarte, Jonatas L.; Amado, Jesus R. R.; Cruz, Rodrigo A. S.; Rocha, Clarice F.

Association between Potentially Inappropriate Medication (PIM) Use and Risk of Hospitalization in Older Adults: An Observational Study Based on Routine Data Comparing PIM Use with Use of PIM Alternatives
Endres, Heinz G.; Kaufmann-Kolle, Petra; Steeb, Valerie; Bauer, Erik; Boettner, Caroline

Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics
Joubert, Marisa K.; Deshpande, Meghana; Yang, Jane; Reynolds, Helen; Bryson, Christine

Naringin Decreases TNF-alpha and HMGB1 Release from LPS-Stimulated Macrophages and Improves Survival in a CLP-Induced Sepsis Mice
Gil, Minchan; Kim, Yun Kyu; Hong, Sang Bum; Lee, Kyung Jin

Long-Circulating Curcumin-Loaded Liposome Formulations with High Incorporation Efficiency, Stability and Anticancer Activity towards Pancreatic Adenocarcinoma Cell Lines In Vitro
Mahmud, Mohamed; Piwoni, Adriana; Filiczak, Nina; Janicka, Martyna; Gubernator, Jerzy

Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis
Tiveron, Ana Paula; Rosalen, Pedro Luiz; Franchin, Marcelo; Coelho Lacerda, Risia Cristina; Bueno-Silva, Bruno



Physics, Multidisciplinary


Large-Scale Analysis of Zipf's Law in English Texts
Moreno-Sanchez, Isabel; Font-Clos, Francesc; Corral, Alvaro

Detecting Causality by Combined Use of Multiple Methods: Climate and Brain Examples
Hirata, Yoshito; Amigo, Jose M.; Matsuzaka, Yoshiya; Yokota, Ryo; Mushiake, Hajime

Utility Evaluation Based on One-To-N Mapping in the Prisoner's Dilemma Game for Interdependent Networks
Wang, Juan; Lu, Wenwen; Liu, Lina; Li, LI; Xia, Chengyi

Superconductivity in Bismuth. A New Look at an Old Problem
Mata-Pinzon, Zaahel; Valladares, Ariel A.; Valladares, Renela M.; Valladares, Alexander

The Anatomy of the Global Football Player Transfer Network: Club Functionalities versus Network Properties
Liu, Xiao Fan; Liu, Yu-liang; Lu, Xin-Hang; Wang, Qi-Xuan; Wang, Tong-xing

Fractional Dynamics of Network Growth Constrained by Aging Node Interactions
Safdari, Hadiseh; Kamali, Milad Zare; Shirazi, Amirhossein; Khalighi, Moein; Jafari, Gholamreza

A Universal Rank-Size Law
Ausloos, Marcel; Cerqueti, Roy

Study of Robustness in Functionally Identical Coupled Networks against Cascading Failures
Wang, Xingyuan; Cao, Jianye; Qin, Xiaomeng

Demand and Congestion in Multiplex Transportation Networks
Chodrow, Philip S.; Al-awwad, Zeyad; Jiang, Shan; Gonzalez, Marta C.

Can Network Linkage Effects Determine Return? Evidence from Chinese Stock Market
Qiao, Haishu; Xia, Yue; Li, Ying



Plant Sciences


Transcriptomic Analysis of Tea Plant Responding to Drought Stress and Recovery
Liu, Sheng-Chuan; Jin, Ji-Qiang; Ma, Jian-Qiang; Yao, Ming-Zhe; Ma, Chun-Lei

Transcriptome Analysis Provides Insights into the Mechanisms Underlying Wheat Plant Resistance to Stripe Rust at the Adult Plant Stage
Hao, Yingbin; Wang, Ting; Wang, Kang; Wang, Xiaojie; Fu, Yanping

Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene OsERF922
Wang, Fujun; Wang, Chunlian; Liu, Piqing; Lei, Cailin; Hao, Wei

ABA Is Required for Plant Acclimation to a Combination of Salt and Heat Stress
Suzuki, Nobuhiro; Bassil, Elias; Hamilton, Jason S.; Inupakutika, Madhuri A.; Zandalinas, Sara Izquierdo

Screening Reliable Reference Genes for RT-qPCR Analysis of Gene Expression in Moringa oleifera
Deng, Li-Ting; Wu, Yu-Ling; Li, Jun-Cheng; Ouyang, Kun-xi; Ding, Mei-mei

Leaf Mass per Area (LMA) and Its Relationship with Leaf Structure and Anatomy in 34 Mediterranean Woody Species along a Water Availability Gradient
de la Riva, Enrique G.; Olmo, Manuel; Poorter, Hendrik; Luis Ubera, Jose; Villar, Rafael

Transcriptome Analysis of Salt Stress Responsiveness in the Seedlings of Dongxiang Wild Rice (Oryza rufipogon Griff.)
Zhou, YI; Yang, Ping; Cui, Fenglei; Zhang, Fantao; Luo, Xiangdong

Responses of Rapid Viscoanalyzer Profile and Other Rice Grain Qualities to Exogenously Applied Plant Growth Regulators under High Day and High Night Temperatures
Fahad, Shah; Hussain, Saddam; Saud, Shah; Hassan, Shah; Chauhan, Bhagirath Singh

Authentication of Herbal Supplements Using Next-Generation Sequencing
Ivanova, Natalia V.; Kuzmina, Maria L.; Braukmann, Thomas W. A.; Borisenko, Alex V.; Zakharov, Evgeny V.

The Multifarious PGPR Serratia marcescens CDP-13 Augments Induced Systemic Resistance and Enhanced Salinity Tolerance of Wheat (Triticum aestivum L.)
Singh, Rajnish Prakash; Jha, Prabhat Nath





Screening for Depression in the General Population with the Center for Epidemiologic Studies Depression (CES-D): A Systematic Review with Meta-Analysis
Vilagut, Gemma; Forero, Carlos G.; Barbaglia, Gabriela; Alonso, Jordi

Meta-Analysis of Longitudinal Cohort Studies of Suicide Risk Assessment among Psychiatric Patients: Heterogeneity in Results and Lack of Improvement over Time
Large, Matthew; Kaneson, Muthusamy; Myles, Nicholas; Myles, Hannah; Gunaratne, Pramudie

A Systematic Review of Cognitive Behavioral Therapy and Behavioral Activation Apps for Depression
Huguet, Anna; Rao, Sanjay; McGrath, Patrick J.; Wozney, Lori; Wheaton, Mike

Major Depression as a Complex Dynamic System
Cramer, Angelique O. J.; van Borkulo, Claudia D.; Giltay, Erik J.; van der Maas, Han L. J.; Kendler, Kenneth S.

Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort
Sugden, Karen; Moffitt, Terrie E.; Pinto, Lauriane; Poulton, Richie; Williams, Benjamin S.

The Effectiveness of Cognitive Bias Modification Interventions for Substance Addictions: A Meta-Analysis
Cristea, Ioana A.; Kok, Robin N.; Cuijpers, Pim

Can We Increase Psychological Well-Being? The Effects of Interventions on Psychological Well-Being: A Meta-Analysis of Randomized Controlled Trials
Weiss, Laura A.; Westerhof, Gerben J.; Bohlmeijer, Ernst T.

Prospective Associations between Depression and Obesity for Adolescent Males and Females- A Systematic Review and Meta-Analysis of Longitudinal Studies
Mannan, Munim; Mamun, Abdullah; Doi, Suhail; Clavarino, Alexandra

Development and Validation of a Self-Report Measure of Mentalizing: The Reflective Functioning Questionnaire
Fonagy, Peter; Luyten, Patrick; Moulton-Perkins, Alesia; Lee, Ya-Wen; Warren, Fiona

Depression-Burnout Overlap in Physicians
Wurm, Walter; Vogel, Katrin; Holl, Anna; Ebner, Christoph; Bayer, Dietmar



Public, Environmental & Occupational Health


Global Economic Burden of Norovirus Gastroenteritis
Bartsch, Sarah M.; Lopman, Benjamin A.; Ozawa, Sachiko; Hall, Aron J.; Lee, Bruce Y.

Assessing the Effect of mHealth Interventions in Improving Maternal and Neonatal Care in Low- and Middle-Income Countries: A Systematic Review
Sondaal, Stephanie Felicie Victoria; Browne, Joyce Linda; Amoakoh-Coleman, Mary; Borgstein, Alexander; Miltenburg, Andrea Solnes

Falls and Fall-Related Injuries among Community-Dwelling Adults in the United States
Verma, Santosh K.; Willetts, Joanna L.; Corns, Helen L.; Marucci-Wellman, Helen R.; Lombardi, David A.

Barriers and Facilitators to the Uptake and Maintenance of Healthy Behaviours by People at Mid-Life: A Rapid Systematic Review
Kelly, Sarah; Martin, Steven; Kuhn, Isla; Cowan, Andy; Brayne, Carol

Outness, Stigma, and Primary Health Care Utilization among Rural LGBT Populations
Whitehead, J.; Shaver, John; Stephenson, Rob

World Health Organization Estimates of the Relative Contributions of Food to the Burden of Disease Due to Selected Foodborne Hazards: A Structured Expert Elicitation
Hald, Tine; Aspinall, Willy; Devleesschauwer, Brecht; Cooke, Roger; Corrigan, Tim

Leveraging the Social Determinants of Health: What Works?
Taylor, Lauren A.; Tan, Annabel Xulin; Coyle, Caitlin E.; Ndumele, Chima; Rogan, Erika

Public Parks and Wellbeing in Urban Areas of the United States
Larson, Lincoln R.; Jennings, Viniece; Cloutier, Scott A.

Fine Particulate Air Pollution and Hospital Emergency Room Visits for Respiratory Disease in Urban Areas in Beijing, China, in 2013
Xu, Qin; Li, Xia; Wang, Shuo; Wang, Chao; Huang, Fangfang

Association between Electronic Cigarette Use and Asthma among High School Students in South Korea
Cho, Jun Ho; Paik, Samuel Y.



Radiology, Nuclear Medicine & Medical Imaging


Quantitative Susceptibility Mapping in Parkinson's Disease
Langkammer, Christian; Pirpamer, Lukas; Seiler, Stephan; Deistung, Andreas; Schweser, Ferdinand

Switching Monopolar Radiofrequency Ablation Using a Separable Cluster Electrode in Patients with Hepatocellular Carcinoma: A Prospective Study
Choi, Jin Woo; Lee, Jeong Min; Lee, Dong Ho; Yoon, Jeong-Hee; Suh, Kyung-Suk

Magnetic Particle/Magnetic Resonance Imaging: In-Vitro MPI-Guided Real Time Catheter Tracking and 4D Angioplasty Using a Road Map and Blood Pool Tracer Approach
Salamon, Johannes; Hofmann, Martin; Jung, Caroline; Kaul, Michael Gerhard; Werner, Franziska

Standardized Reporting of Prostate MRI: Comparison of the Prostate Imaging Reporting and Data System (PI-RADS) Version 1 and Version 2
Tewes, Susanne; Mokov, Nikolaj; Hartung, Dagmar; Schick, Volker; Peters, Inga

Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Women
Yao, Wang; Gan, YU; Myers, Kristin M.; Vink, Joy Y.; Wapner, Ronald J.

Motion-Correction Enabled Ultra-High Resolution In-Vivo 7T-MRI of the Brain
Federau, Christian; Gallichan, Daniel

Validation of Fully Automated VMAT Plan Generation for Library-Based Plan-of-the-Day Cervical Cancer Radiotherapy
Sharfo, Abdul Wahab M.; Breedveld, Sebastiaan; Voet, Peter W. J.; Heijkoop, Sabrina T.; Mens, Jan-Willem M.

Assessing Agreement between Radiomic Features Computed for Multiple CT Imaging Settings
Lu, Lin; Ehmke, Ross C.; Schwartz, Lawrence H.; Zhao, Binsheng

Ultra Low Dose CT Pulmonary Angiography with Iterative Reconstruction
Sauter, Andreas; Koehler, Thomas; Fingerle, Alexander A.; Brendel, Bernhard; Richter, Vivien

Diffusion-Weighted MRI Reflects Proliferative Activity in Primary CNS Lymphoma
Schob, Stefan; Meyer, Jonas; Gawlitza, Matthias; Frydrychowicz, Clara; Mueller, Wolf



Respiratory System


Impact of Comorbidities on Mortality in Patients with Idiopathic Pulmonary Fibrosis
Kreuter, Michael; Ehlers-Tenenbaum, Svenja; Palmowski, Karin; Bruhwyler, Jacques; Oltmanns, Ute

Airway Microbiota in Severe Asthma and Relationship to Asthma Severity and Phenotypes
Zhang, Qingling; Cox, Michael; Liang, Zhike; Brinkmann, Folke; Cardenas, Paul A.

The Minimal Important Difference in Physical Activity in Patients with COPD
Demeyer, Heleen; Burtin, Chris; Hornikx, Miek; Camillo, Carlos Augusto; Van Remoortel, Hans

Validation of the Recording of Acute Exacerbations of COPD in UK Primary Care Electronic Healthcare Records
Rothnie, Kieran J.; Muellerova, Hana; Hurst, John R.; Smeeth, Liam; Davis, Kourtney

Bronchiectasis as a Comorbidity of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
Du, Qingxia; Jin, Jianmin; Liu, Xiaofang; Sun, Yongchang

Continuing to Confront COPD International Patient Survey: Economic Impact of COPD in 12 Countries
Foo, Jason; Landis, Sarah H.; Maskell, Joe; Oh, Yeon-Mok; van der Molen, Thys

Clinical Phenotypes and Comorbidity in European Sleep Apnoea Patients
Saaresranta, Tarja; Hedner, Jan; Bonsignore, Maria R.; Riha, Renata L.; McNicholas, Walter T.

Nontuberculous Mycobacterial Disease in Children - Epidemiology, Diagnosis & Management at a Tertiary Center
Tebruegge, Marc; Pantazidou, Anastasia; MacGregor, Duncan; Gonis, Gena; Leslie, David

Psycho-Socio-Economic Issues Challenging Multidrug Resistant Tuberculosis Patients: A Systematic Review
Thomas, Beena Elizabeth; Shanmugam, Poonguzhali; Malaisamy, Muniyandi; Ovung, Senthanro; Suresh, Chandra

Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis
Balestro, Elisabetta; Calabrese, Fiorella; Turato, Graziella; Lunardi, Francesca; Bazzan, Erica



Sport Sciences


Twelve Weeks of Sprint Interval Training Improves Indices of Cardiometabolic Health Similar to Traditional Endurance Training despite a Five-Fold Lower Exercise Volume and Time Commitment
Gillen, Jenna B.; Martin, Brian J.; MacInnis, Martin J.; Skelly, Lauren E.; Tarnopolsky, Mark A.

Accuracy of Heart Rate Watches: Implications for Weight Management
Wallen, Matthew P.; Gomersall, Sjaan R.; Keating, Shelley E.; Wisloff, Ulrik; Coombes, Jeff S.

Inter-Individual Variability in the Adaptive Responses to Endurance and Sprint Interval Training: A Randomized Crossover Study
Bonafiglia, Jacob T.; Rotundo, Mario P.; Whittall, Jonathan P.; Scribbans, Trisha D.; Graham, Ryan B.

Why Are Girls Less Physically Active than Boys? Findings from the LOOK Longitudinal Study
Telford, Rohan M.; Telford, Richard D.; Olive, Lisa S.; Cochrane, Thomas; Davey, Rachel

Comparison of High-Intensity Interval Training and Moderate-to-Vigorous Continuous Training for Cardiometabolic Health and Exercise Enjoyment in Obese Young Women: A Randomized Controlled Trial
Kong, Zhaowei; Fan, Xitao; Sun, Shengyan; Song, Lili; Shi, Qingde

No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes
Rankinen, Tuomo; Fuku, Noriyuki; Wolfarth, Bernd; Wang, Guan; Sarzynski, Mark A.

Older Adults with Dementia Are Sedentary for Most of the Day
van Alphen, Helena J. M.; Volkers, Karin M.; Blankevoort, Christiaan G.; Scherder, Erik J. A.; Hortobagyi, Tibor

Effects of Varying Epoch Lengths, Wear Time Algorithms, and Activity Cut-Points on Estimates of Child Sedentary Behavior and Physical Activity from Accelerometer Data
Banda, Jorge A.; Haydel, K. Farish; Davila, Tania; Desai, Manisha; Bryson, Susan

Pumping Iron in Australia: Prevalence, Trends and Sociodemographic Correlates of Muscle Strengthening Activity Participation from a National Sample of 195,926 Adults
Bennie, Jason A.; Pedisic, Zeljko; van Uffelen, Jannique G. Z.; Charity, Melanie J.; Harvey, Jack T.

Metabolic Power Requirement of Change of Direction Speed in Young Soccer Players: Not All Is What It Seems
Hader, Karim; Mendez-Villanueva, Alberto; Palazzi, Dino; Ahmaidi, Said; Buchheit, Martin





Recipient Age and Mortality Risk after Liver Transplantation: A Population-Based Cohort Study
Chen, Hsiu-Pin; Tsai, Yung-Fong; Lin, Jr-Rung; Liu, Fu-Chao; Yu, Huang-Ping

Long-Term Outcomes of Patients with Acute Cholecystitis after Successful Percutaneous Cholecystostomy Treatment and the Risk Factors for Recurrence: A Decade Experience at a Single Center
Wang, Chih-Hung; Wu, Cheng-Yi; Yang, Justin Cheng-Ta; Lien, Wan-Ching; Wang, Hsiu-Po

Change in Adverse Events After Enrollment in the National Surgical Quality Improvement Program: A Systematic Review and Meta-Analysis
Montroy, Joshua; Breau, Rodney H.; Cnossen, Sonya; Witiuk, Kelsey; Binette, Andrew

Adjusted Age-Adjusted Charlson Comorbidity Index Score as a Risk Measure of Perioperative Mortality before Cancer Surgery
Chang, Chun-Ming; Yin, Wen-Yao; Wei, Chang-Kao; Wu, Chin-Chia; Su, Yu-Chieh

Cytotoxicity of Cyanoacrylate-Based Tissue Adhesives and Short-Term Preclinical In Vivo Biocompatibility in Abdominal Hernia Repair
Pascual, Gemma; Sotomayor, Sandra; Rodriguez, Marta; Perez-Koehler, Barbara; Kuehnhardt, Andree

A Smartphone App and Cloud-Based Consultation System for Burn Injury Emergency Care
Wallis, Lee A.; Fleming, Julian; Hasselberg, Marie; Laflamme, Lucie; Lundin, Johan

Robotic versus Laparoscopic Distal Pancreatectomy: A Meta-Analysis of Short-Term Outcomes
Zhou, Jia-Yu; Xin, Chang; Mou, Yi-Ping; Xu, Xiao-Wu; Zhang, Miao-Zun

A Patient Registry to Improve Patient Safety: Recording General Neurosurgery Complications
Sarnthein, Johannes; Stieglitz, Lennart; Clavien, Pierre-Alain; Regli, Luca

Economic Analysis of Children's Surgical Care in Low- and Middle-Income Countries: A Systematic Review and Analysis
Saxton, Anthony T.; Poenaru, Dan; Ozgediz, Doruk; Ameh, Emmanuel A.; Farmer, Diana

Contemporary Management Strategies for Chronic Type B Aortic Dissections: A Systematic Review
Kamman, Arnoud V.; de Beaufort, Hector W. L.; van Bogerijen, Guido H. W.; Nauta, Foeke J. H.; Heijmen, Robin H.



Tropical Medicine


Prevalence of pfhrp2 and/or pfhrp3 Gene Deletion in Plasmodium falciparum Population in Eight Highly Endemic States in India
Bharti, Praveen Kumar; Chandel, Himanshu Singh; Ahmad, Amreen; Krishna, Sri; Udhayakumar, Venkatachalam

The Effect of Indoor Residual Spraying on the Prevalence of Malaria Parasite Infection, Clinical Malaria and Anemia in an Area of Perennial Transmission and Moderate Coverage of Insecticide Treated Nets in Western Kenya
Gimnig, John E.; Otieno, Peter; Were, Vincent; Marwanga, Doris; Abong'o, Daisy

Use of Malachite Green-Loop Mediated Isothermal Amplification for Detection of Plasmodium spp. Parasites
Lucchi, Naomi W.; Ljolje, Dragan; Silva-Flannery, Luciana; Udhayakumar, Venkatachalam

Personal Protection of Permethrin-Treated Clothing against Aedes aegypti, the Vector of Dengue and Zika Virus, in the Laboratory
Orsborne, James; Banks, Sarah DeRaedt; Hendy, Adam; Gezan, Salvador A.; Kaur, Harparkash

Submicroscopic and Asymptomatic Plas-modium Parasitaemia Associated with Significant Risk of Anaemia in Papua, Indonesia
Pava, Zuleima; Burdam, Faustina H.; Handayuni, Irene; Trianty, Leily; Utami, Retno A. S.

The Cure Rate after Placebo or No Therapy in American Cutaneous Leishmaniasis: A Systematic Review and Meta-Analysis
Cota, Glaucia Fernandes; de Sousa, Marcos Roberto; Fereguetti, Tatiani Oliveira; Saleme, Priscila Said; Alvarisa, Thais Kawagoe

Performance of Microscopy for the Diagnosis of Malaria and Human African Trypanosomiasis by Diagnostic Laboratories in the Democratic Republic of the Congo: Results of a Nation-Wide External Quality Assessment
Mukadi, Pierre; Lejon, Veerle; Barbe, Barbara; Gillet, Philippe; Nyembo, Christophe

Distribution of Voltage-Gated Sodium Channel (Nav) Alleles among the Aedes aegypti Populations In Central Java Province and Its Association with Resistance to Pyrethroid Insecticides
Sayono, Sayono; Hidayati, Anggie Puspa Nur; Fahri, Sukmal; Sumanto, Didik; Dharmana, Edi

A Chlorfenapyr Mixture Net Interceptor (R) G2 Shows High Efficacy and Wash Durability against Resistant Mosquitoes in West Africa
N'Guessan, Raphael; Odjo, Abibatou; Ngufor, Corine; Malone, David; Rowland, Mark

A Comprehensive Entomological, Serological and Molecular Study of 2013 Dengue Outbreak of Swat, Khyber Pakhtunkhwa, Pakistan
Khan, Jehangir; Khan, Inamullah; Amin, Ibne



Urology & Nephrology


Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis
Hill, Nathan R.; Fatoba, Samuel T.; Oke, Jason L.; Hirst, Jennifer A.; O'Callaghan, Christopher A.

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease
Missailidis, Catharina; Hallqvist, Jenny; Qureshi, Abdel Rashid; Barany, Peter; Heimburger, Olof

Urinary Exosomal miRNA Signature in Type II Diabetic Nephropathy Patients
Delic, Denis; Eisele, Claudia; Schmid, Ramona; Baum, Patrick; Wiech, Franziska

Clinical Nomograms to Predict Stone-Free Rates after Shock-Wave Lithotripsy: Development and Internal-Validation
Kim, Jung Kwon; Ha, Seung Beom; Jeon, Chan Hoo; Oh, Jong Jin; Cho, Sung Yong

Comparison of Retrograde Balloon Dilatation and Laparoscopic Pyeloplasty for Treatment of Ureteropelvic Junction Obstruction: Results of a 2-Year Follow-Up
Xu, Ning; Chen, Shao-Hao; Xue, Xue-Yi; Zheng, Qing-Shui; Wei, Yong

Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways
Gao, Zhao; Han, Yu; Hu, Yunhui; Wu, Xiaoyan; Wang, Yongbin

Robotic Assisted Radical Cystectomy with Extracorporeal Urinary Diversion Does Not Show a Benefit over Open Radical Cystectomy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Tan, Wei Shen; Khetrapal, Pramit; Tan, Wei Phin; Rodney, Simon; Chau, Marisa

Unilateral Renal Ischemia-Reperfusion as a Robust Model for Acute to Chronic Kidney Injury in Mice
Le Clef, Nathalie; Verhulst, Anja; D'Haese, Patrick C.; Vervaet, Benjamin A.

Mouse Models of Diabetes, Obesity and Related Kidney Disease
Glastras, Sarah J.; Chen, Hui; Teh, Rachel; McGrath, Rachel T.; Chen, Jason

Comparative Effectiveness of Phosphate Binders in Patients with Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis
Sekercioglu, Nigar; Thabane, Lehana; Martinez, Juan Pablo Diaz; Nesrallah, Gihad; Longo, Christopher J.



Veterinary Sciences


Identification of a Divergent Lineage Porcine Pestivirus in Nursing Piglets with Congenital Tremors and Reproduction of Disease following Experimental Inoculation
Arruda, Bailey L.; Arruda, Paulo H.; Magstadt, Drew R.; Schwartz, Kent J.; Dohlman, Tyler

Pain and Laboratory Animals: Publication Practices for Better Data Reproducibility and Better Animal Welfare
Carbone, Larry; Austin, Jamie

Real-Time Reverse Transcription PCR Assay for Detection of Senecavirus A in Swine Vesicular Diagnostic Specimens
Bracht, Alexa J.; O'Hearn, Emily S.; Fabian, Andrew W.; Barrette, Roger W.; Sayed, Abu

Piscine Orthoreovirus from Western North America Is Transmissible to Atlantic Salmon and Sockeye Salmon but Fails to Cause Heart and Skeletal Muscle Inflammation
Garver, Kyle A.; Johnson, Stewart C.; Polinski, Mark P.; Bradshaw, Julia C.; Marty, Gary D.

Housing and Demographic Risk Factors Impacting Foot and Musculoskeletal Health in African Elephants [Loxodonta africana] and Asian Elephants [Elephas maximus] in North American Zoos
Miller, Michele A.; Hogan, Jennifer N.; Meehan, Cheryl L.

Assessment of Body Condition in African (Loxodonta africana) and Asian (Elephas maximus) Elephants in North American Zoos and Management Practices Associated with High Body Condition Scores
Morfeld, Kari A.; Meehan, Cheryl L.; Hogan, Jennifer N.; Brown, Janine L.

The Economic Impact of Eradicating Peste des Petits Ruminants: A Benefit-Cost Analysis
Jones, Bryony A.; Rich, Karl M.; Mariner, Jeffrey C.; Anderson, John; Jeggo, Martyn

Excessive Pro-Inflammatory Serum Cytokine Concentrations in Virulent Canine Babesiosis
Goddard, Amelia; Leisewitz, Andrew L.; Kjelgaard-Hansen, Mads; Kristensen, Annemarie T.; Schoeman, Johan P.

Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma
Maekawa, Naoya; Konnai, Satoru; Okagawa, Tomohiro; Nishimori, Asami; Ikebuchi, Ryoyo

Presence of Vaccine-Derived Newcastle Disease Viruses in Wild Birds
Ayala, Andrea J.; Dimitrov, Kiril M.; Becker, Cassidy R.; Goraichuk, Iryna V.; Arns, Clarice W.





Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems
Bialek, Julia K.; Dunay, Gabor A.; Voges, Maike; Schaefer, Carola; Spohn, Michael

Reassortment of Human and Animal Rotavirus Gene Segments in Emerging DS-1-Like G1P[8] Rotavirus Strains
Komoto, Satoshi; Tacharoenmuang, Ratana; Guntapong, Ratigorn; Ide, Tomihiko; Tsuji, Takao

Norovirus Epidemiology in Africa: A Review
Mans, Janet; Armah, George E.; Steele, A. Duncan; Taylor, Maureen B.

Revelation of Influencing Factors in Overall Codon Usage Bias of Equine Influenza Viruses
Kumar, Naveen; Bera, Bidhan Chandra; Greenbaum, Benjamin D.; Bhatia, Sandeep; Sood, Richa

Genome Wide Host Gene Expression Analysis in Chicken Lungs Infected with Avian Influenza Viruses
Ranaware, Pradip B.; Mishra, Anamika; Vijayakumar, Periyasamy; Gandhale, Pradeep N.; Kumar, Himanshu

Frequent Occurrence of Tomato Leaf Curl New Delhi Virus in Cotton Leaf Curl Disease Affected Cotton in Pakistan
Zaidi, Syed Shan-e-Ali; Shafiq, Muhammad; Amin, Imran; Scheffler, Brian E.; Scheffler, Jodi A.

De Novo Assembly of Human Herpes Virus Type 1 (HHV-1) Genome, Mining of Non-Canonical Structures and Detection of Novel Drug-Resistance Mutations Using Short- and Long-Read Next Generation Sequencing Technologies
Karamitros, Timokratis; Harrison, Ian; Piorkowska, Renata; Katzourakis, Aris; Magiorkinis, Gkikas

Norovirus Recombinant Strains Isolated from Gastroenteritis Outbreaks in Southern Brazil, 2004-2011
Fumian, Tulio Machado; Ribeiro de Andrade, Juliana da Silva; Gagliardi Leite, Jose Paulo; Miagostovich, Marize Pereira

Prevalence and Genetic Diversity of Enteric Viruses in Children with Diarrhea in Ouagadougou, Burkina Faso
Ouedraogo, Nafissatou; Kaplon, Jerome; Bonkoungou, Isidore Juste O.; Traore, Alfred Sababenedjo; Pothier, Pierre

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8
Soto, Cinque; Ofek, Gilad; Joyce, M. Gordon; Zhang, Baoshan; McKee, Krisha

Learn More

Like to hear about new research first?   Find your next opportunity to publish with us

Journal Information

PLOS ONE publishes primary research across all areas of science, including interdisciplinary research. Research articles are selected for scientific rigor rather than perceived impact, enabling us to publish the complete canon of research, including validation studies, negative results studies, and more.

Email questions to