Low reproducibility rates have undermined trust in the scientific enterprise. Meta-research, or the scientific study of research practices, is an emerging field that aims to characterize existing standards and ultimately improve the quality and reliability of scientific research. To mark the launch of a new data-driven meta-research section in PLOS Biology we collect here some meta-research ‘classics’, as well as some of the most recent offerings, across PLOS. These articles highlight key issues that hinder the scientific effort and offer ways to improve research practices. 

Meta-research: Evaluation and Improvement of Research Methods and Practices

John P. A. Ioannidis, Daniele Fanelli, Debbie Drake Dunne, Steven N. Goodman

PLOS Biology: 2 October 2015


Meta-Research: Methods



Meta-Research: Reporting



Meta-Research: Sources of Bias



Meta-Research: Reproducibility



Meta-Research: Evaluation and Scientometrics



Meta-Research: Policy and Interventions



Meta-Research: Tools for Improving Biomedical Research