ASPirin in Reducing Events in the Elderly (ASPREE), a placebo-controlled prevention trial of low dose aspirin, provided the opportunity to…
Medicine & Health
Aging in Human Health and Disease
Advances in modern medicine mean many people can expect to live far longer than in previous generations. According to the World Health Organization, the number of people aged 60 years and older will increase to 1.4 billion by 2030 and 2.1 billion by 2050*. At a global level, the growing aging population currently presents a challenge to health and social care systems, and is expected to increase significantly.
In this collection, PLOS One highlights multidisciplinary research in the area of aging, including research articles and study protocols exploring quality of life in geriatric and palliative care populations, creation of a healthy aging biobank, challenges in accessing care and health monitoring, mental health in aged populations, cognitive changes in aging, and the impact of older age in a range of diseases.
* Data sources: Ageing and Health [Internet]. [cited 17 October 2024]. Available from: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health
Image Credit: Front view of old man in a nursing home by Freepik, Freepik
PLOS ONE
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PLOS ONE The ASPREE Healthy Ageing Biobank: Methodology and participant characteristics
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PLOS ONE Social cognitive predictors of regular dental visits and mouth self-examination behaviors among the elderly population: An application of the health action process approach model
Objective: The present study aimed to identify the social cognitive predictors of regular dental visits and mouth self-examination…
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PLOS ONE Sex differences in health-related quality of life and poverty risk among older people living with HIV in Spain: A cross-sectional study
Background: Current antiretroviral therapies have increased the life expectancy of people living with HIV (PLHIV). There is, however,…
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PLOS ONE Older adults’ suggestions of research topics on ageing well in urban environments – A participatory study
Background: Ageing societies and urbanization are global phenomena that pose new challenges for care delivery. It is important to create a…
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PLOS ONE Impact of subjective well-being on physical frailty in middle-aged and elderly Japanese with high social isolation
Social isolation exacerbates physical frailty and is associated with subjective well-being. Even those with high levels of social…
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PLOS ONE Impact of obesity on intensive care unit outcomes in older patients with critical illness: A cohort study
Background: Although the paradoxical association between obesity and improved survival has been reported in a variety of clinical settings,…
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PLOS ONE Depression and associated factors among older people in Vietnam: Findings from a National Aging Survey
Background: Depression is one of the most common mental health disorders among older people. Depressive symptoms are often overlooked and…
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PLOS ONE Cognitive-Cognitive Dual-task in aging: A cross-sectional online study
The prevalence of neurodegenerative disorders, particularly dementia, is on the rise across many countries worldwide. This negative trend…
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PLOS ONE Child support grant expansion and cognitive function among women in rural South Africa: Findings from a natural experiment in the HAALSI cohort
Background: Cash transfers are a promising but understudied intervention that may protect cognitive function in adults. Although South…
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PLOS ONE Bone quality, mineral density, and fractures in heart failure
Background: The trabecular bone score (TBS) indirectly estimates bone quality and predicts low-impact fractures independently of bone…
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PLOS ONE Beyond traditional training: Integrating data from semi-immersive VR dual-task intervention in Parkinsonian Syndromes. A study protocol
Completing cognitive and motor tasks simultaneously requires a high level of cognitive control in terms of executive processes and…
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PLOS ONE A protocol for remote collection of skeletal muscle mass via D3-creatine dilution in community-dwelling postmenopausal women from the Women’s Health Initiative
Background: There is emerging evidence that cancer and its treatments may accelerate the normal aging process, increasing the magnitude and…
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PLOS ONE Transition of mild cognitive impairment to Alzheimer’s disease: Medications as modifiable risk factors
Background: Mild cognitive impairment (MCI) is a pre-clinical stage of Alzheimer’s disease (AD). Understanding the transition probabilities…
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PLOS ONE Barriers to care for dependent older adults: Brazilian Primary Health Care managers’ perspective
This study analyzes the perspective of 16 managers from different Brazilian regions about the barriers to adequate care for dependent…
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PLOS ONE Impact of aging on acute myeloid leukemia epidemiology and survival outcomes: A real-world, population-based longitudinal cohort study
Acute myeloid leukemia (AML) is a severe and fatal form of leukemia that is prevalent in the older population. In this longitudinal…
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PLOS ONE Increased patient satisfaction by integration of palliative care into geriatrics—A prospective cohort study
Background: Integration of oncology and palliative care has been shown to increase quality of life in advanced disease. To meet the needs…