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Autophagy or “self-eating” is a process by which the cell removes misfolded proteins and damaged organelles in times of stress and starvation.
This tightly regulated process is important for maintaining energy balance and its dysregulation of has been demonstrated to play a role in the development of cancer, neurodegeneration and ageing.
In this Editor's Picks, PLOS ONE Associate Editor Adya Misra showcases some of the research highlighting the importance of autophagy in cancer and neurodegenerative disease as well various modulators of this process. To learn more about this topic, read the related blog Stressful Conditions That Cause Self-Eating: Autophagy within the Cell.