Biology & Life Sciences
Cancer Research
Cancers figure among the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and 8.2 million cancer related deaths each year. It is expected that annual cancer cases will rise from 14 million in 2012 to 22 within the next 2 decades. Knowledge about the causes of cancer and interventions to prevent and manage the disease is extensive and is continually growing. Whilst many patients now have improved prognosis if their cancer is detected early and treated adequately, new research is being regularly published on preventing and curing cancer. This Collection highlights some of this research published in PLOS journals over the last few years.
Image Credit: National Cancer Institute, National Institutes of Health
Risk factors and stratification
Reproducibility in cancer research
Cancer metabolism and bioenergetics
Immunotherapy
Cancer diagnostics
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PLOS Genetics Fragment Length of Circulating Tumor DNA
Clinical research practices
Drug targets and activity
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PLOS Computational Biology Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling
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PLOS Computational Biology Spatial Heterogeneity in Drug Concentrations Can Facilitate the Emergence of Resistance to Cancer Therapy
Signaling networks
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PLOS Computational Biology A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion
Mutational analysis
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PLOS Computational Biology Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples
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PLOS Computational Biology Protein Domain-Level Landscape of Cancer-Type-Specific Somatic Mutations
Pathways for DNA damage and repair
Proteomic approaches
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PLOS Computational Biology A systematic atlas of chaperome deregulation topologies across the human cancer landscape
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PLOS Computational Biology A Multi-Method Approach for Proteomic Network Inference in 11 Human Cancers
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PLOS Computational Biology A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces
Epigenetic regulators
Cancer genetics
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PLOS Computational Biology Network perturbation by recurrent regulatory variants in cancer
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PLOS Computational Biology Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution
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PLOS Genetics Clonality and Evolutionary History of Rhabdomyosarcoma
Tumor heterogeneity
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PLOS Computational Biology Evolution and Phenotypic Selection of Cancer Stem Cells
Virus-associated malignancies
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PLOS Pathogens Common Commensal Cancer Viruses
Bacterial and parasitic infection-associated cancers
Methods, tools and resources
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PLOS Computational Biology Network-Based Isoform Quantification with RNA-Seq Data for Cancer Transcriptome Analysis