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Small molecules that allow us to observe and manipulate biological systems by targeting and binding to specific targets are powerful tools in the field of Chemical Biology. These probes can inhibit a protein’s function, interact with nucleic acids, disrupt cellular processes and pathways, as well as allow researchers to study how a biological target functions within a given system. In this Editor’s Picks, PLOS ONE Associate Editor Carla Pegoraro highlights some of the latest research on the development and uses of chemical probes, including in vivo and in vitro imaging, drug discovery, protein functions and cellular processes.
July 6, 2015William N. Pappano, Jun Guo, Yupeng He, Debra Ferguson, Sujatha Jagadeeswaran, Donald J. Osterling, Wenqing Gao, Julie K. Spence, Marina Pliushchev, Ramzi F. Sweis, Fritz G. Buchanan, Michael R. Michaelides, Alexander R. Shoemaker, Chris Tse, Gary G. Chiang
August 6, 2015Lin Hong, Yuna Guo, Soumik BasuRay, Jacob O. Agola, Elsa Romero, Denise S. Simpson, Chad E. Schroeder, Peter Simons, Anna Waller, Matthew Garcia, Mark Carter, Oleg Ursu, Kristine Gouveia, Jennifer E. Golden, Jeffrey Aubé, Angela Wandinger-Ness, Larry A. Sklar
August 23, 2016Christie A. Bader, Tetyana Shandala, Elizabeth A. Carter, Angela Ivask, Taryn Guinan, Shane M. Hickey, Melissa V. Werrett, Phillip J. Wright, Peter V. Simpson, Stefano Stagni, Nicolas H. Voelcker, Peter A. Lay, Massimiliano Massi, Sally E. Plush, Douglas A. Brooks
June 25, 2015Anzhelika G. Vorobyeva, Michael Stanton, Aurélien Godinat, Kjetil B. Lund, Grigory G. Karateev, Kevin P. Francis, Elizabeth Allen, Juri G. Gelovani, Emmet McCormack, Mark Tangney, Elena A. Dubikovskaya