Medicine & Health

Autoimmune Diseases

Published October 17, 2016 Curated Collections

The Clinical Immunology Collection has been organized into broad categories in response to the commonly articulated request from our users that we provide more structured and efficient access to papers of interest in the PLOS corpus. This section includes papers about autoimmune diseases.

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Research Articles

Research Articles

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10.1371/journal.pcbi.1004005

PLOS Computational Biology Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms
January 8, 2015 J. Matthew Mahoney, Jaclyn Taroni, Viktor Martyanov, Tammara A. Wood, Casey S. Greene, Patricia A. Pioli, Monique E. Hinchcliff, Michael L. Whitfield
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10.1371/journal.pgen.1005248

PLOS Genetics Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease
June 9, 2015 Maria Wilbe, Sergey V. Kozyrev, Fabiana H. G. Farias, Hanna D. Bremer, Anna Hedlund, Gerli R. Pielberg, Eija H. Seppälä, Ulla Gustafson, Hannes Lohi, Örjan Carlborg, Göran Andersson, Helene Hansson-Hamlin, Kerstin Lindblad-Toh
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10.1371/journal.pgen.1006008

PLOS Genetics Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 Gene
May 5, 2016 Dan Vodo, Ofer Sarig, Shamir Geller, Edna Ben-Asher, Tsviya Olender, Ron Bochner, Ilan Goldberg, Judith Nosgorodsky, Anna Alkelai, Pavel Tatarskyy, Alon Peled, Sharon Baum, Aviv Barzilai, Saleh M. Ibrahim, Detlef Zillikens, Doron Lancet, Eli Sprecher
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10.1371/journal.pbio.1001881

PLOS Biology Hypoxia-Inducible Factor-2α Is an Essential Catabolic Regulator of Inflammatory Rheumatoid Arthritis
June 10, 2014 Je-Hwang Ryu, Chang-Suk Chae, Ji-Sun Kwak, Hwanhee Oh, Youngnim Shin, Yun Hyun Huh, Choong-Gu Lee, Yong-Wook Park, Churl-Hong Chun, Young-Myeong Kim, Sin-Hyeog Im, Jang-Soo Chun
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NIAID/NIH, Wikimedia Commons / PLOS

PLOS ONE A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis
January 12, 2012 Franca Guerini, Rachele Cagliani, Diego Forni, Cristina Agliardi, Domenico Caputo, Andrea Cassinotti, Daniela Galimberti, Chiara Fenoglio, Mara Biasin, Rosanna Asselta, Elio Scarpini, Giacomo Comi, Nereo Bresolin, Mario Clerici, Manuela Sironi
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10.1371/journal.pgen.1002454

PLOS Genetics DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes
January 19, 2012 Kristina Gervin, Magnus Vigeland, Morten Mattingsdal, Martin Hammerø, Heidi Nygård, Anne Olsen, Ingunn Brandt, Jennifer Harris, Dag Undlien, Robert Lyle
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10.1371/journal.pone.0030275

PLOS ONE Systematic Review and Meta-Analysis of the Efficacy and Safety of Existing TNF Blocking Agents in Treatment of Rheumatoid Arthritis
January 17, 2012 Kalle Aaltonen, Liisa Virkki, Antti Malmivaara, Yrjö Konttinen, Dan Nordström, Marja Blom
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10.1371/journal.pone.0029888

PLOS ONE Brain Viscoelasticity Alteration in Chronic-Progressive Multiple Sclerosis
January 20, 2012 Kaspar-Josche Streitberger, Ingolf Sack, Dagmar Krefting, Caspar Pfüller, Jürgen Braun, Friedemann Paul, Jens Wuerfel
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10.1371/journal.pgen.1002514

PLOS Genetics Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease
February 16, 2012 Haoyan Chen, Genki Hayashi, Olivia Lai, Alexander Dilthey, Peter Kuebler, Tami Wong, Maureen Martin, Marcelo Fernandez Vina, Gil McVean, Matthias Wabl, Kieron Leslie, Toby Maurer, Jeffrey Martin, Steven Deeks, Mary Carrington, Anne Bowcock, Douglas Nixon, Wilson Liao
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10.1371/journal.pone.0032487

PLOS ONE Population Based Study of 12 Autoimmune Diseases in Sardinia, Italy: Prevalence and Comorbidity
March 2, 2012 Claudia Sardu, Eleonora Cocco, Alessandra Mereu, Roberta Massa, Alessandro Cuccu, Maria Marrosu, Paolo Contu
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10.1371/journal.pgen.1002559

PLOS Genetics A Genome-Wide Scan of Ashkenazi Jewish Crohn’s Disease Suggests Novel Susceptibility Loci
March 8, 2012 Eimear Kenny, Itsik Pe'er, Amir Karban, Laurie Ozelius, Adele Mitchell, Sok Meng Ng, Monica Erazo, Harry Ostrer, Clara Abraham, Maria Abreu, Gil Atzmon, Nir Barzilai, Steven Brant, Edward Burns, Yehuda Chowers, Lorraine Clark, Ariel Darvasi, Dana Doheny, Richard Duerr, Rami Eliakim, Nir Giladi, Peter Gregersen, Hakon Hakonarson, Michelle Jones, Dermot McGovern, Jennifer Mulle, Avi Orr-Urtreger, Deborah Proctor, Ann Pulver, Jerome Rotter, Mark Silverberg, Thomas Ullman, Stephen Warren, Matti Waterman, Wei Zhang, Aviv Bergman, Lloyd Mayer, Seymour Katz, Robert Desnick, Judy Cho, Inga Peter
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10.1371/journal.ppat.1002715

PLOS Pathogens Gammaherpesvirus Latency Accentuates EAE Pathogenesis: Relevance to Epstein-Barr Virus and Multiple Sclerosis
May 17, 2012 Costanza Casiraghi, Iryna Shanina, Seyhun Cho, Michael Freeman, Marcia Blackman, Marc Horwitz
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10.1371/journal.pgen.1002934

PLOS Genetics Citrullination of Histone H3 Interferes with HP1-Mediated Transcriptional Repression
September 13, 2012 Priyanka SHARMA, Saliha AZEBI, Patrick ENGLAND, Tove CHRISTENSEN, Anné MØLLER-LARSEN, Thor PETERSEN, Eric BATSCHE, Christian Muchardt
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10.1371/journal.pone.0046740

PLOS ONE Adipokines in Psoriatic Arthritis Patients: The Correlations with Osteoclast Precursors and Bone Erosions
October 29, 2012 Yu Xue, Li Jiang, Qingqing Cheng, Haiyan CHEN, Yiyun Yu, Yinda LIN, Xue Yang, xue Xu, Ning Kong, Xiaoxia Zhu, Weiguo Wan, Hejian Zou
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10.1371/journal.pone.0049133

PLOS ONE IL12RB2 Gene Is Associated with the Age of Type 1 Diabetes Onset in Croatian Family Trios
November 13, 2012 Marina Pehlić, Dina Vrkić, Veselin Škrabić, Ana Jerončić, Gordana Stipančić, Anita Špehar Urojić, Igor Marjanac, Jasminka Jakšić, Zrinka Kačić, Vesna Boraska, Tatijana Zemunik
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10.1371/journal.pone.0051506

PLOS ONE Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis
December 19, 2012 Carolina Barragán-Martínez, Cesar Speck-Hernández, Gladis Montoya-Ortiz, Rubén Mantilla, Juan-Manuel Anaya, Adriana Rojas-Villarraga
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10.1371/journal.pgen.1003147

PLOS Genetics A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)
January 10, 2013 Rohina Rubicz, Robert Yolken, Eugene Drigalenko, Melanie Carless, Thomas Dyer, Lara Bauman, Phillip Melton, Jack Kent, Jr., John Harley, Ravindranath Duggirala, Joanne Curran, Matthew Johnson, Shelley Cole, Laura Almasy, Eric Moses, Nikhil Dhurandhar, Ellen Kraig, John Blangero, Charles Leach, Harald Goring
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10.1371/journal.pgen.1003225

PLOS Genetics Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers
January 31, 2013 Gordan Lauc, Jennifer Huffman, Maja Pučić, Lina Zgaga, Barbara Adamczyk, Ana Mužinić, Mislav Novokmet, Ozren Polašek, Olga Gornik, Jasminka Krištić, Toma Keser, Veronique Vitart, Blanca Scheijen, Hae-Won Uh, Mariam Molokhia, Alan Patrick, Paul McKeigue, Ivana Kolčić, Ivan-Kresimir Lukić, Olivia Swann, Frank van Leeuwen, L. Renee Ruhaak, Jeanine Houwing-Duistermaat, P. Eline Slagboom, Marian Beekman, Anton de Craen, André Deelder, Qiang Zeng, Wei Wang, Nicholas Hastie, Ulf Gyllensten, James Wilson, Manfred Wuhrer, Alan Wright, Pauline Rudd, Caroline Hayward, Yurii Aulchenko, Harry Campbell, Igor Rudan
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10.1371/journal.pone.0054841

PLOS ONE Targeting the Shift from M1 to M2 Macrophages in Experimental Autoimmune Encephalomyelitis Mice Treated with Fasudil
February 13, 2013 Chunyun Liu, Yanhua Li, Jiezhong Yu, Ling Feng, Shaowei Hou, Yueting Liu, Mingfang Guo, Yong Xie, Jian Meng, Haifei Zhang, Cungen Ma, baoguo Xiao
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10.1371/journal.pgen.1003270

PLOS Genetics ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy
February 14, 2013 Juliette Faraco, Ling Lin, Brigitte Kornum, Eimear Kenny, Gosia Trynka, Mali Einen, Tom Rico, Peter Lichtner, Yves Dauvilliers, Isabelle Arnulf, Michel Lecendreux, Sirous Javidi, Peter Geisler, Geert Mayer, Fabio Pizza, Francesca Poli, Giuseppe Plazzi, Sebastiaan Overeem, Gert Jan Lammers, David Kemlink, Karel Sonka, Sona Nevsimalova, Guy Rouleau, Alex Desautels, Jacques Montplaisir, Birgit Frauscher, Laura Ehrmann, Birgit Högl, Poul Jennum, Patrice Bourgin, Rosa Peraita-Adrados, Alex Iranzo, Claudio Bassetti, Wei-Min Chen, Patrick Concannon, Susan Thompson, Vincent Damotte, Bertrand Fontaine, Maxime Breban, Christian Gieger, Norman Klopp, Panos Deloukas, Cisca Wijmenga, Joachim Hallmayer, Suna Onengut-Gumuscu, Stephen Rich, Juliane Winkelmann, Emmanuel Mignot
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10.1371/journal.pgen.1003336

PLOS Genetics MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus
February 28, 2013 Yun Deng, Jian Zhao, Daisuke Sakurai, Kenneth Kaufman, Jeffrey Edberg, Robert Kimberly, Diane Kamen, Gary Gilkeson, Chaim Jacob, R Scofield, Carl Langefeld, Jennifer Kelly, Rosalind Ramsey-Goldman, Michelle Petri, John Reveille, Luis Vilá, Graciela Alarcón, Timothy Vyse, Bernardo Pons-Estel, Barry Freedman, Patrick Gaffney, Kathy Sivils, Judith James, Peter Gregersen, Juan-Manuel Anaya, Timothy Niewold, Joan Merrill, Lindsey Criswell, Anne Stevens, Susan Boackle, Rita Cantor, Weiling Chen, Jeniffer Grossman, Bevra Hahn, John Harley, Marta Alarcόn-Riquelme, Elizabeth Brown, Betty Tsao
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10.1371/journal.pgen.1003394

PLOS Genetics Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis
March 28, 2013 Jing Cui, Eli Stahl, Saedis Saevarsdottir, Corinne Miceli, Dorothee Diogo, Gosia Trynka, Towfique Raj, Maša Mirkov, Helena Canhao, Katsunori Ikari, Chikashi Terao, Yukinori Okada, Sara Wedrén, Johan Askling, Hisashi Yamanaka, Shigeki Momohara, Atsuo Taniguchi, Koichiro Ohmura, Fumihiko Matsuda, Tsuneyo Mimori, Namrata Gupta, Manik Kuchroo, Ann Morgan, John Isaacs, Anthony Wilson, Kimme Hyrich, Marieke Herenius, Marieke Doorenspleet, Paul-Peter Tak, J Bart Crusius, Irene van der Horst-Bruinsma, Gert Wolbink, Piet van Riel, Mart van de Laar, Henk-Jan Guchelaar, Nancy Shadick, Cornelia Allaart, Tom Huizinga, Rene Toes, Robert Kimberly, S. Louis Bridges Jr, Lindsey Criswell, Larry Moreland, João Eurico Fonseca, Niek de Vries, Barbara Stranger, Philip De Jager, Soumya Raychaudhuri, Michael Weinblatt, Peter Gregersen, Xavier Mariette, Anne Barton, Leonid Padyukov, Marieke Coenen, Elizabeth Karlson, Robert Plenge
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10.1371/journal.pone.0071382

PLOS ONE Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population
August 22, 2013 Kiyoshi Migita, Minoru Nakamura, Seigo Abiru, Yuka Jiuchi, Shinya Nagaoka, Atsumasa Komori, Satoru Hashimoto, Shigemune Bekki, Kazumi Yamasaki, Tatsuji Komatsu, Masaaki Shimada, Hiroshi Kouno, Taizo Hijioka, Motoyuki Kohjima, Makoto Nakamuta, Michio Kato, Kaname Yoshizawa, Hajime Ohta, Yoko Nakamura, Eiichi Takezaki, Hideo Nishimura, Takeaki Sato, Keisuke Ario, Noboru Hirashima, Yukio Oohara, Atsushi Naganuma, Toyokichi Muro, Hironori Sakai, Eiji Mita, Kazuhiro Sugi, Haruhiro Yamashita, Fujio Makita, Hiroshi Yatsuhashi, Hiromi Ishibashi, Michio Yasunami
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10.1371/journal.pgen.1003678

PLOS Genetics Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations
August 8, 2013 Devin Absher, Xinrui Li, Lindsay Waite, Andrew Gibson, Kevin Roberts, Jeffrey Edberg, Winn Chatham, Robert Kimberly
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10.1371/journal.pone.0073088

PLOS ONE Circulating Microparticles from Crohn’s Disease Patients Cause Endothelial and Vascular Dysfunctions
September 3, 2013 Daniela Leonetti, Jean-Marie Reimund, Angela Tesse, Stéphanie Viennot, M Carmen Martinez, Anne-Laure Bretagne, Ramaroson Andriantsitohaina
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10.1371/journal.pgen.1003926

PLOS Genetics Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects
November 21, 2013 Nikolaos Patsopoulos, Lisa Barcellos, Rogier Hintzen, Catherine Schaefer, Cornelia van Duijn, Janelle Noble, Towfique Raj, Pierre-Antoine Gourraud, Barbara Stranger, Jorge Oksenberg, Tomas Olsson, Bruce Taylor, Stephen Sawcer, David Hafler, Mary Carrington, Philip De Jager, Paul de Bakker
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10.1371/journal.pone.0081736

PLOS ONE Tumor Necrosis Factor B (TNFB) Genetic Variants and Its Increased Expression Are Associated with Vitiligo Susceptibility
November 27, 2013 Naresh Laddha, Mitesh Dwivedi, Amina Gani, Mohmmad Shoab Mansuri, Rasheedunnisa Begum
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10.1371/journal.pone.0081685

PLOS ONE Increased B Cell and Cytotoxic NK Cell Proportions and Increased T Cell Responsiveness in Blood of Natalizumab-Treated Multiple Sclerosis Patients
December 2, 2013 Johan Mellergård, Måns Edström, Maria Jenmalm, Charlotte Dahle, Magnus Vrethem, Jan Ernerudh
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10.1371/journal.pgen.1004123

PLOS Genetics Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease
February 27, 2014 Marco Medici, Eleonora Porcu, Giorgio Pistis, Alexander Teumer, Suzanne Brown, Richard Jensen, Rajesh Rawal, Greet Roef, Theo Plantinga, Sita Vermeulen, Jari Lahti, Matthew Simmonds, Lise Lotte Husemoen, Rachel Freathy, Beverley Shields, Diana Pietzner, Rebecca Nagy, Linda Broer, Layal Chaker, Tim Korevaar, Maria Grazia Plia, Cinzia Sala, Uwe Völker, J Brent Richards, Fred Sweep, Christian Gieger, Tanguy Corre, Eero Kajantie, Betina Thuesen, Youri Taes, W Edward Visser, Andrew Hattersley, Jürgen Kratzsch, Alexander Hamilton, Wei Li, Georg Homuth, Monia Lobina, Stefano Mariotti, Nicole Soranzo, Massimiliano Cocca, Matthias Nauck, Christin Spielhagen, Alec Ross, Alice Arnold, Martijn van de Bunt, Sandya Liyanarachchi, Margit Heier, Hans Jörgen Grabe, Corrado Masciullo, Tessel Galesloot, Ee Lim, Eva Reischl, Peter Leedman, Sandra Lai, Alessandro Delitala, Alexandra Bremner, David Philips, John Beilby, Antonella Mulas, Matteo Vocale, Goncalo Abecasis, Tom Forsen, Alan James, Elisabeth Widen, Jennie Hui, Holger Prokisch, Ernst Rietzschel, Aarno Palotie, Peter Feddema, Stephen Fletcher, Katharina Schramm, Jerome Rotter, Alexander Kluttig, Dörte Radke, Michela Traglia, Gabriela Surdulescu, Huiling He, Jayne Franklyn, Daniel Tiller, Bijay Vaidya, Tim de Meyer, Torben Jørgensen, Johan Eriksson, Peter O'Leary, Eric Wichmann, Ad Hermus, Bruce Psaty, Till Ittermann, Albert Hofman, Emanuele Bosi, David Schlessinger, Henri Wallaschofski, Nicola Pirastu, Yurii Aulchenko, Albert de la Chapelle, Romana Netea-Maier, Stephen Gough, Henriette Meyer zu Schwabedissen, Timothy Frayling, Jean-Marc Kaufman, Allan Linneberg, Katri Räikkönen, Johannes Smit, Lambertus Kiemeney, Fernando Rivadeneira, André Uitterlinden, John Walsh, Christa Meisinger, Martin den Heijer, Theo Visser, Timothy Spector, Scott Wilson, Henry Völzke, Anne Cappola, Daniela Toniolo, Serena Sanna, Silvia Naitza, Robin Peeters
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10.1371/journal.pone.0099068

PLOS ONE Early Treatment with Anti-VLA-4 mAb Can Prevent the Infiltration and/or Development of Pathogenic CD11b⁺CD4⁺ T Cells in the CNS during Progressive EAE
June 4, 2014 John Mindur, Naoko Ito, Suhayl Dhib-Jalbut, Kouichi Ito

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