Medicine & Health

DeWorm3

Published April 23, 2020 Partnered Collections, Special Issues

Soil-transmitted helminths infect an estimated 1.45 billion people globally. The current WHO strategy for controlling STH is based on controlling morbidity via mass drug administration of medications to children. However, recent mathematical models and systematic reviews suggest that the current strategy of targeting children with MDA is unlikely to break transmission of STH, in large part due to the presence of adult reservoirs of disease. This collection highlights both the existing evidence and new methodological approaches needed for generating the evidence necessary for informing potential novel--and significant--intervention strategies and policy changes.

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Research Articles

Research Articles

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10.1371/journal.pntd.0008153

PLOS Neglected Tropical Diseases Gender norms and mass deworming program access in Comé, Benin: A qualitative assessment of gender-associated opportunities and challenges to achieving high mass drug administration coverage
April 17, 2020 Rachel E. Geyer, Moudachirou Ibikounlé, Mira Emmanuel-Fabula, Amy Roll, Euripide Avokpaho, Abiguel Elijan, Léopold Codjo Wèkè, Comlanvi Innocent Togbevi, Félicien Chabi, Parfait Houngbégnon, Adrian J. F. Luty, Elodie Yard, Judd L. Walson, Susan Graham, Arianna Rubin Means
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10.1371/journal.pntd.0006864

PLOS Neglected Tropical Diseases Defining stopping criteria for ending randomized clinical trials that investigate the interruption of transmission of soil-transmitted helminths employing mass drug administration
October 1, 2018 Marleen Werkman, Jaspreet Toor, Carolin Vegvari, James E. Wright, James E. Truscott, Kristjana H. Ásbjörnsdóttir, Arianna Rubin Means, Judd L. Walson, Roy M. Anderson
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AJC1

PLOS Neglected Tropical Diseases Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol
January 18, 2018 Kristjana Ásbjörnsdóttir, Sitara Ajjampur, Roy Anderson, Robin Bailey, Iain Gardiner, Katherine Halliday, Moudachirou Ibikounle, Khumbo Kalua, Gagandeep Kang, D. Timothy Littlewood, Adrian Luty, Arianna Means, William Oswald, Rachel Pullan, Rajiv Sarkar, Fabian Schär, Adam Szpiro, James Truscott, Marleen Werkman, Elodie Yard, Judd Walson
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SuSanA Secretariat

PLOS Neglected Tropical Diseases Evaluating the sustainability, scalability, and replicability of an STH transmission interruption intervention: The DeWorm3 implementation science protocol
January 18, 2018 Arianna Means, Sitara Ajjampur, Robin Bailey, Katya Galactionova, Marie-Claire Gwayi-Chore, Katherine Halliday, Moudachirou Ibikounle, Sanjay Juvekar, Khumbo Kalua, Gagandeep Kang, Pallavi Lele, Adrian Luty, Rachel Pullan, Rajiv Sarkar, Fabian Schär, Fabrizio Tediosi, Judd Walson, Bryan Weiner, Elodie Yard
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E.L. Davis et al

PLOS Neglected Tropical Diseases Seasonally timed treatment programs for Ascaris lumbricoides to increase impact – An investigation using mathematical models
January 18, 2018 Emma Davis, Leon Danon, Joaquin Prada, Sharmini Gunawardena, James Truscott, Johnny Vlaminck, Roy Anderson, Bruno Levecke, Eric Morgan, T Deirdre Hollingsworth
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M. Papaiakovou et al

PLOS Neglected Tropical Diseases A comparative analysis of preservation techniques for the optimal molecular detection of hookworm DNA in a human fecal specimen
January 18, 2018 Marina Papaiakovou, Nils Pilotte, Ben Baumer, Jessica Grant, Kristjana Asbjornsdottir, Fabian Schaer, Yan Hu, Raffi Aroian, Judd Walson, Steven Williams
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M. Werkman et al

PLOS Neglected Tropical Diseases Testing for soil-transmitted helminth transmission elimination: Analysing the impact of the sensitivity of different diagnostic tools
January 18, 2018 Marleen Werkman, James Wright, James Truscott, Alice Easton, Rita Oliveira, Jaspreet Toor, Alison Ower, Kristjana Ásbjörnsdóttir, Arianna Means, Sam Farrell, Judd Walson, Roy Anderson
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SuSanA Secretariat

PLOS Neglected Tropical Diseases Assessment of serum pharmacokinetics and urinary excretion of albendazole and its metabolites in human volunteers
January 18, 2018 Laura Ceballos, Alejandro Krolewiecki, Marisa Juárez, Laura Moreno, Fabian Schaer, Luis Alvarez, Rubén Cimino, Judd Walson, Carlos Lanusse
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A. Krolewiecki et al

PLOS Neglected Tropical Diseases Safety and pharmacokinetic profile of fixed-dose ivermectin with an innovative 18mg tablet in healthy adult volunteers
January 18, 2018 Jose Muñoz, Maria Rosa Ballester, Rosa Maria Antonijoan, Ignasi Gich, Montse Rodriguez, Enrico Colli, Silvia Gold, Alejandro Krolewiecki
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SuSan A Secretariat

PLOS Neglected Tropical Diseases Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults
January 18, 2018 Arianna Means, Lisette van Lieshout, Eric Brienen, Krista Yuhas, James Hughes, Paul Ndungu, Benson Singa, Judd Walson
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Vivien Rolfe

PLOS Neglected Tropical Diseases Geographical distribution of soil transmitted helminths and the effects of community type in South Asia and South East Asia – A systematic review
January 18, 2018 Zachary Silver, Saravanakumar Kaliappan, Prasanna Samuel, Srinivasan Venugopal, Gagandeep Kang, Rajiv Sarkar, Sitara Ajjampur
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10.1371/journal.pntd.0006211

PLOS Neglected Tropical Diseases Strategies to improve treatment coverage in community-based public health programs: A systematic review of the literature
February 8, 2018 Katrina Deardorff, Arianna Rubin Means, Kristjana Ásbjörnsdóttir, Judd Walson
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10.1371/journal.pntd.0006213

PLOS Neglected Tropical Diseases Diagnostic tools for soil-transmitted helminths control and elimination programs: A pathway for diagnostic product development
March 1, 2018 Mark D. Lim, Simon J. Brooker, Vicente Y. Belizario Jr., Françoise Gay-Andrieu, John Gilleard, Bruno Levecke, Lisette van Lieshout, Graham F. Medley, Zeleke Mekonnen, Greg Mirams, Sammy M. Njenga, Maurice R. Odiere, James W. Rudge, Lieven Stuyver, Jozef Vercruysse, Johnny Vlaminck, Judd L. Walson, the Annecy STH diagnostic experts group