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Biology & Life Sciences

The DREAM Systems Biology Challenges

Partnered Collections, Special Issues

The Dialogue for Reverse Engineering Assessments and Methods (DREAM) grew as a community effort to catalyze discussion about the design, application, and assessment of systems biology models through annual conferences and reverse-engineering and predictive modeling challenges. The various challenges, based on anonymized data sets, tested participants in network inference and prediction of measurements. These challenges encompass a variety of problems at the core of systems biology, such as network inference, determination of diagnostic signatures, prediction of outcomes of biological systems as a result of perturbations, transcriptional dynamics, protein-protein recognition, etc. The collection summarizes the lessons learned by the DREAM community and provides a much-needed context for interpreting claims of efficacy of algorithms described in the scientific literature.

Image Credit: Gustavo Stolovitzky

Overview
Research
The DREAM project

The DREAM project is sponsored by NCI through its Columbia University Center for Multiscale Analysis Genomic and Cellular Networks (MAGNet) and by the IBM Computational Biology Center.

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