Medicine & Health

Drug Delivery

Published November 22, 2021 Calls for Papers Collections

The efficacy and safety of a drug is highly impacted not only by how it is designed, but also by how and where it is delivered. In recent years there has been significant progress in the formulation of different drug delivery systems to improve the release and pharmacological profile of therapeutic drugs, reduce side effects, and enhance targeting to specific tissues and cell types.

This collection welcomed a range of submissions including those that report on the various properties of drug delivery systems as well as in vitro and in vivo studies and submissions that deal with computational studies of drug delivery systems or that focus on the clinical applications of delivery systems.

Image Credit: Syringe CC BY 4.0

Jump to section

Guest Editors
PLOS ONE

Guest Editors

Image credit
CC BY 2.0

Guest Editor, PLOS ONE Robert Luxenhofer
November 22, 2021

University of Helsinki, Finland
Image credit
CC BY 2.0

Guest Editor, PLOS ONE Vivek Gupta
November 22, 2021

St. John’s University, USA

PLOS ONE

Image credit
10.1371/journal.pone.0241006 CC BY 4.0

PLOS ONE The effects of PEGylation on LNP based mRNA delivery to the eye
October 29, 2020 Renee C. Ryals, Siddharth Patel, Chris Acosta, Madison McKinney, Mark E. Pennesi, Gaurav Sahay

Gene therapy is now an effective approach to treat many forms of retinal degeneration. Delivery agents that are cell-specific, allow for…
Image credit
10.1371/journal.pone.0240156 CC BY 4.0

PLOS ONE Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites
October 6, 2020 Sameh S. M. Soliman, Tasneem B. Alhamidi, Shifaa Abdin, Ahmed M. Almehdi, Mohammad H. Semreen, Razan B. Alhumaidi, Sarra B. Shakartalla, Mohamed Haider, Mohamed I. Husseiny, Hany A. Omar

Biogenic synthesis of nanoparticles provides many advantages over synthetic nanoparticles including clean and non-toxic approaches.…
Image credit
10.1371/journal.pone.0241718 CC BY 4.0

PLOS ONE Evaluation of bioabsorbable calcium sulfate hemihydrate beads for local delivery of carboplatin
November 5, 2020 Marine Traverson, Connor E. Stewart, Mark G. Papich

The objectives of this study were to evaluate a novel kit of resorbable calcium sulfate beads marketed specifically for use in veterinary…
Image credit
10.1371/journal.pone.0242565 CC BY 4.0

PLOS ONE Crystallization of carboplatin-loaded onto microporous calcium phosphate using high-vacuum method: Characterization and release study
December 8, 2020 Cristiane Savicki, Nelson Heriberto Almeida Camargo, Enori Gemelli

Drug delivery systems are a new approach to increase therapeutic efficacy and to reduce the side effects of traditional treatments.…
Image credit
10.1371/journal.pone.0248133 CC BY 4.0

PLOS ONE Radon-220 diffusion from ²²⁴Ra-labeled calcium carbonate microparticles: Some implications for radiotherapeutic use
March 4, 2021 Elisa Napoli, Tina B. Bønsdorff, Ida Sofie Jorstad, Øyvind S. Bruland, Roy H. Larsen, Sara Westrøm

Alpha-particle emitting radionuclides continue to be the subject of medical research because of their high energy and short range of…
Image credit
10.1371/journal.pone.0250599 CC BY 4.0

PLOS ONE Genistein as a dietary supplement; formulation, analysis and pharmacokinetics study
April 27, 2021 Alexandra Mamagkaki, Ioannis Bouris, Panagiotis Parsonidis, Ioanna Vlachou, Maria Gougousi, Ioannis Papasotiriou

The objective of this study is to improve and optimize the formulation of Genistein in capsules in order to result in a better…
Image credit
10.1371/journal.pone.0241157 CC BY 4.0

PLOS ONE Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides
January 6, 2021 Motohiro Nonaka, Hideaki Mabashi-Asazuma, Donald L. Jarvis, Kazuhiko Yamasaki, Tomoya O. Akama, Masato Nagaoka, Toshio Sasai, Itsuko Kimura-Takagi, Yoichi Suwa, Takashi Yaegashi, Chun-Teng Huang, Chizuko Nishizawa-Harada, Michiko N. Fukuda

We previously reported that IF7 peptide, which binds to the annexin A1 (ANXA1) N-terminus, functions as a tumor vasculature-targeted drug…
Image credit
10.1371/journal.pone.0254765 CC BY 4.0

PLOS ONE Dispersive effects and focused biodistribution of recombinant human hyaluronidase PH20: A locally acting and transiently active permeation enhancer
July 22, 2021 David W. Kang, Beate Bittner, Barry J. Sugarman, Monica L. Zepeda, Marie A. Printz

Background: Recombinant human hyaluronidase PH20 (rHuPH20) facilitates the dispersion and absorption of subcutaneously administered…
Image credit
10.1371/journal.pone.0250670 CC BY 4.0

PLOS ONE A novel preparative method for nanoparticle albumin-bound paclitaxel with high drug loading and its evaluation both in vitro and in vivo
April 28, 2021 Yue Gao, Jingxue Nai, Zhenbo Yang, Jinbang Zhang, Siyu Ma, Yumei Zhao, Hui Li, Jiaxin Li, Yang Yang, Meiyan Yang, Yuli Wang, Wei Gong, Fanglin Yu, Chunsheng Gao, Zhiping Li, Xingguo Mei

We developed a novel preparative method for nanoparticle albumin-bound (nab) paclitaxel with high drug loading, which was based on…
Image credit
Untitled by Brunaugh et al., CC BY 4.0

PLOS ONE Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae
February 11, 2021 Ashlee D. Brunaugh, Hyojong Seo, Zachary Warnken, Li Ding, Sang Heui Seo, Hugh D. C. Smyth

Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-2, the causative agent of the COVID-19 pandemic.…
Image credit
10.1371/journal.pone.0249683 CC BY 4.0

PLOS ONE Puerarin dry powder inhaler formulations for pulmonary delivery: Development and characterization
April 13, 2021 Md Abdur Rashid, Saiqa Muneer, Tony Wang, Yahya Alhamhoom, Llew Rintoul, Emad L. Izake, Nazrul Islam

This study aims at developing and characterizing the puerarin dry powder inhaler (DPI) formulations for pulmonary delivery. The inhalable…
Image credit
10.1371/journal.pone.0251821 CC BY 4.0

PLOS ONE Formulation of tunable size PLGA-PEG nanoparticles for drug delivery using microfluidic technology
June 18, 2021 Adrianna Glinkowska Mares, Gaia Pacassoni, Josep Samitier Marti, Silvia Pujals, Lorenzo Albertazzi

Amphiphilic block co-polymer nanoparticles are interesting candidates for drug delivery as a result of their unique properties such as the…
Image credit
10.1371/journal.pone.0248257 CC BY 4.0

PLOS ONE Chitosan-olive oil microparticles for phenylethyl isothiocyanate delivery: Optimal formulation
May 6, 2021 Ezequiel R. Coscueta, Ana Sofia Sousa, Celso A. Reis, Manuela Pintado

Phenylethyl isothiocyanate (PEITC), a chemopreventive compound, is highly reactive due to its considerably electrophilic nature.…

Open your research for discovery.

Submit your research to PLOS ONE.

Submit now!

Follow PLOS ONE on Twitter

To keep up-to-date on the latest research.