Biology & Life Sciences

Malaria: Targets and Drugs for All Stages

Published May 24, 2018 Curated Collections

Drug research in malaria often focuses on blood stage parasites because they are responsible for the symptoms of the disease and are easier to manipulate in the laboratory.This collection describes multiple parasite and host processes engaged in infection in blood, the blocking of which could stop human illness. However, control and eradication of malaria will also require the development of drugs against stages responsible for mosquito transmission and those that remain latent in the liver, also summarized in the collection. Although these selected papers represent significant research at the highest levels, they are only a fraction of the malaria drug discovery literature. The collection highlights PLOS authors’ contribution to basic drug discovery research.

Image Credit: Image Credit: Delves M, Plouffe D, Scheurer C, Meister S, et al.

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Introductory Articles
Overview
Targeting the parasite: Blood Stages - Invasion
Targeting the parasite: Blood Stages - Growth/replication within infected erythrocyte
Targeting the parasite: Blood Stages - Sexual stages
Targeting the parasite: All blood (asexual and sexual) stages
Targeting the parasite: Liver Stages
Targeting the parasite: Insect Stage
Targeting the host: Human/Mammal
Targeting the host: Vector
Targeting the parasite: Coinfections
Testing Implementation and Outcomes Studies in Human Populations: Control/treatment
Testing Implementation and Outcomes Studies in Human Populations: Epidemiology

Introductory Articles

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10.1371/journal.ppat.1003365

Speaking of Medicine Drugs for Malaria: Need to Overcome Resistance to Artemisinins and Eliminate All Stages of Parasites in a Wide Range of Transmission and Disease Settings
April 27, 2015 Kasturi Haldar, Margaret Phillips
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10.1371/journal.pmed.1001169

Speaking of Medicine Malaria: Targets and Drugs for All Stages
April 27, 2015 Kasturi Haldar, Margaret Phillips

Overview

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10.1371/journal.pmed.1001169

PLOS Medicine The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites
February 21, 2012 Michael Delves, David Plouffe, Christian Scheurer, Stephan Meister, Sergio Wittlin, Elizabeth Winzeler, Robert Sinden, Didier Leroy

Targeting the parasite: Blood Stages - Invasion

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10.1371/journal.ppat.0010029

PLOS Pathogens Molecular Identification of a Malaria Merozoite Surface Sheddase
November 25, 2005 Philippa K Harris, Sharon Yeoh, Anton R Dluzewski, Rebecca A O'Donnell, Chrislaine Withers-Martinez, Fiona Hackett, Lawrence H Bannister, Graham H Mitchell, Michael J Blackman
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10.1371/journal.ppat.0020113

PLOS Pathogens Two Plasmodium Rhomboid Proteases Preferentially Cleave Different Adhesins Implicated in All Invasive Stages of Malaria
October 13, 2006 Rosanna P Baker, Ruvini Wijetilaka, Sinisa Urban
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10.1371/journal.ppat.0020117

PLOS Pathogens Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates Erythrocyte Invasion
November 3, 2006 Kailash C Pandey, Naresh Singh, Shirin Arastu-Kapur, Matthew Bogyo, Philip J Rosenthal
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10.1371/journal.ppat.0030107

PLOS Pathogens Epigenetic Silencing of Plasmodium falciparum Genes Linked to Erythrocyte Invasion
August 3, 2007 Alfred Cortés, Celine Carret, Osamu Kaneko, Brian Y. S. Yim Lim, Alasdair Ivens, Anthony A Holder
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10.1371/journal.ppat.1000322

PLOS Pathogens Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process
March 6, 2009 Moritz Treeck, Sonja Zacherl, Susann Herrmann, Ana Cabrera, Maya Kono, Nicole S. Struck, Klemens Engelberg, Silvia Haase, Friedrich Frischknecht, Kota Miura, Tobias Spielmann, Tim W. Gilberger
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10.1371/journal.ppat.1000599

PLOS Pathogens A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite
September 25, 2009 Robert W. Moon, Cathy J. Taylor, Claudia Bex, Rebecca Schepers, David Goulding, Chris J. Janse, Andrew P. Waters, David A. Baker, Oliver Billker
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10.1371/journal.ppat.1000941

PLOS Pathogens Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite
June 3, 2010 Kerstin Leykauf, Moritz Treeck, Paul R. Gilson, Thomas Nebl, Thomas Braulke, Alan F. Cowman, Tim W. Gilberger, Brendan S. Crabb
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10.1371/journal.ppat.1000746

PLOS Pathogens Distinct External Signals Trigger Sequential Release of Apical Organelles during Erythrocyte Invasion by Malaria Parasites
February 5, 2010 Shailja Singh, M. Mahmood Alam, Ipsita Pal-Bhowmick, Joseph A. Brzostowski, Chetan E. Chitnis
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10.1371/journal.ppat.1002197

PLOS Pathogens Plasmodium Protease ROM1 Is Important for Proper Formation of the Parasitophorous Vacuole
September 1, 2011 Iset Vera, Wandy Beatty, Photini Sinnis, Kami Kim
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10.1371/journal.ppat.1002448

PLOS Pathogens Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies
December 15, 2011 Anna Olivieri, Christine Collins, Fiona Hackett, Chrislaine Withers-Martinez, Joshua Marshall, Helen Flynn, J Skehel, Mike Blackman
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10.1371/journal.ppat.1002755

PLOS Pathogens Structural and Functional Insights into the Malaria Parasite Moving Junction Complex
June 21, 2012 Brigitte Vulliez-Le Normand, Michelle Tonkin, Mauld Lamarque, Susann Langer, Sylviane Hoos, Magali Roques, Frederick Saul, Bart Faber, Graham Bentley, Martin Boulanger, Maryse LEBRUN
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10.1371/journal.ppat.1003344

PLOS Pathogens Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress
May 9, 2013 Christine Collins, Fiona Hackett, Malcolm Strath, Maria Penzo, Chrislaine Withers-Martinez, David Baker, Michael Blackman
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10.1371/journal.ppat.1003390

PLOS Pathogens Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175
May 23, 2013 Edwin Chen, May Paing, Nichole Salinas, B. Kim Lee Sim, Niraj Tolia
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10.1371/journal.ppat.1003420

PLOS Pathogens Glycan Masking of Plasmodium vivax Duffy Binding Protein for Probing Protein Binding Function and Vaccine Development
June 13, 2013 Sowmya Sampath, Chris Carrico, Joel Janes, Sairam Gurumoorthy, Claire Gibson, Martin Melcher, Chetan Chitnis, Ruobing Wang, William Schief, Joe Smith
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10.1371/journal.pntd.0002506

PLOS Neglected Tropical Diseases Global Population Structure of the Genes Encoding the Malaria Vaccine Candidate, Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1)
October 31, 2013 Alicia Arnott, Ivo Mueller, Paul Ramsland, Peter Siba, John Reeder, Alyssa Barry
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10.1371/journal.pntd.0002498

PLOS Neglected Tropical Diseases Naturally Acquired Immune Responses to P. vivax Merozoite Surface Protein 3α and Merozoite Surface Protein 9 Are Associated with Reduced Risk of P. vivax Malaria in Young Papua New Guinean Children
November 14, 2013 Danielle Stanisic, Sarah Javati, Benson Kiniboro, Enmoore Lin, Jianlin Jiang, Balwan Singh, Esmeralda Mayer, Peter Siba, Cristian Koepfli, Ingrid Felger, Mary Galinski, Ivo Mueller
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10.1371/journal.pntd.0002489

PLOS Neglected Tropical Diseases Whole Genome Sequencing of Field Isolates Reveals a Common Duplication of the Duffy Binding Protein Gene in Malagasy Plasmodium vivax Strains
November 21, 2013 Didier Menard, Ernest Chan, Christophe Benedet, Arsène Ratsimbasoa, Saorin Kim, Pheaktra Chim, Catherine Do, Benoit Witkowski, Remy Durand, Marc Thellier, Carlo Severini, Eric Legrand, Lise Musset, Bakri Nour, Odile Mercereau-Puijalon, David Serre, Peter Zimmerman
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10.1371/journal.pntd.0002569

PLOS Neglected Tropical Diseases De Novo Assembly of a Field Isolate Genome Reveals Novel Plasmodium vivax Erythrocyte Invasion Genes
December 5, 2013 James Hester, Ernest Chan, Didier Menard, Odile Mercereau-Puijalon, John Barnwell, Peter Zimmerman, David Serre
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10.1371/journal.ppat.1003840

PLOS Pathogens Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1
December 26, 2013 Sheetij Dutta, Lisa Dlugosz, Damien Drew, Xiaopeng Ge, Diouf Ababacar, Yazmin Rovira, J Moch, Meng Shi, Carole Long, Michael Foley, James Beeson, Robin Anders, Kazutoyo Miura, John Haynes, Adrian Batchelor
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10.1371/journal.ppat.1003869

PLOS Pathogens Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC
January 9, 2014 Joseph Batchelor, Brian Malpede, Natalie Omattage, Gregory DeKoster, Katherine Henzler-Wildman, Niraj Tolia
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10.1371/journal.ppat.1003943

PLOS Pathogens Plasmodium falciparum Erythrocyte Invasion: Combining Function with Immune Evasion
March 20, 2014 Gavin Wright, Julian Rayner
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10.1371/journal.ppat.1004091

PLOS Pathogens Structural Differences Explain Diverse Functions of Plasmodium Actins
April 17, 2014 Juha Vahokoski, Saligram Bhargav, Ambroise Desfosses, Maria Andreadaki, Esa-Pekka Kumpula, Silvia Martinez, Alexander Ignatev, Simone Lepper, Friedrich Frischknecht, Inga Siden-Kiamos, Carsten Sachse, Inari Kursula
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10.1371/journal.pntd.0003336

PLOS Neglected Tropical Diseases The Plasmodium vivax Merozoite Surface Protein 3β Sequence Reveals Contrasting Parasite Populations in Southern and Northwestern Thailand
November 20, 2014 Chaturong Putaporntip, Jun Miao, Napaporn Kuamsab, Jetsumon Sattabongkot, Jeeraphat Sirichaisinthop, Somchar Jongwutiwes, Liwang Cui
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10.1371/journal.ppat.1004520

PLOS Pathogens The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human Erythrocytes
December 18, 2014 Amrita Dawn, Shailja Singh, Kunal More, Faiza Siddiqui, Niseema Pachikara, Ghania Ramdani, Gordon Langsley, Chetan Chitnis
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10.1371/journal.ppat.1004670

PLOS Pathogens Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes
February 27, 2015 Greta Weiss, Paul Gilson, Tana Taechalertpaisarn, Wai-Hong Tham, Nienke de Jong, Katherine Harvey, Freya Fowkes, Paul Barlow, Julian Rayner, Gavin Wright, Alan Cowman, Brendan Crabb
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10.1371/journal.pntd.0003644

PLOS Neglected Tropical Diseases Structural Analysis of the Synthetic Duffy Binding Protein (DBP) Antigen DEKnull Relevant for Plasmodium vivax Malaria Vaccine Design
March 20, 2015 Edwin Chen, Nichole Salinas, Francis Ntumngia, John Adams, Niraj Tolia

Targeting the parasite: Blood Stages - Growth/replication within infected erythrocyte

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10.1371/journal.ppat.0020057

PLOS Pathogens A Systematic Map of Genetic Variation in Plasmodium falciparum
June 23, 2006 Claire Kidgell, Sarah K Volkman, Johanna Daily, Justin O Borevitz, David Plouffe, Yingyao Zhou, Jeffrey R Johnson, Karine G. Le Roch, Ousmane Sarr, Omar Ndir, Soulyemane Mboup, Serge Batalov, Dyann F Wirth, Elizabeth A Winzeler
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10.1371/journal.ppat.0020100

PLOS Pathogens Release of Sequestered Malaria Parasites upon Injection of a Glycosaminoglycan
September 29, 2006 Anna M Vogt, Fredrik Pettersson, Kirsten Moll, Cathrine Jonsson, Johan Normark, Ulf Ribacke, Thomas G Egwang, Hans-Peter Ekre, Dorothe Spillmann, Qijun Chen, Mats Wahlgren
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10.1371/journal.ppat.0030099

PLOS Pathogens Microfluidic Modeling of Cell−Cell Interactions in Malaria Pathogenesis
July 20, 2007 Meher Antia, Thurston Herricks, Pradipsinh K Rathod
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10.1371/journal.ppat.1001242

PLOS Pathogens Compartmentation of Redox Metabolism in Malaria Parasites
December 23, 2010 Sebastian Kehr, Nicole Sturm, Stefan Rahlfs, Jude M. Przyborski, Katja Becker
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10.1371/journal.ppat.0040019

PLOS Pathogens Plasmodium falciparum Regulatory Subunit of cAMP-Dependent PKA and Anion Channel Conductance
February 1, 2008 Anaïs Merckx, Marie-Paule Nivez, Guillaume Bouyer, Pietro Alano, Gordon Langsley, Kirk Deitsch, Serge Thomas, Christian Doerig, Stéphane Egée
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10.1371/journal.ppat.1000053

PLOS Pathogens HDP—A Novel Heme Detoxification Protein from the Malaria Parasite
April 25, 2008 Dewal Jani, Rana Nagarkatti, Wandy Beatty, Ross Angel, Carla Slebodnick, John Andersen, Sanjai Kumar, Dharmendar Rathore
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10.1371/journal.ppat.1000084

PLOS Pathogens The Malaria Secretome: From Algorithms to Essential Function in Blood Stage Infection
June 13, 2008 Christiaan van Ooij, Pamela Tamez, Souvik Bhattacharjee, N. Luisa Hiller, Travis Harrison, Konstantinos Liolios, Taco Kooij, Jai Ramesar, Bharath Balu, John Adams, Andy Waters, Chris Janse, Kasturi Haldar
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10.1371/journal.ppat.1000118

PLOS Pathogens An Erythrocyte Vesicle Protein Exported by the Malaria Parasite Promotes Tubovesicular Lipid Import from the Host Cell Surface
August 8, 2008 Pamela A. Tamez, Souvik Bhattacharjee, Christiaan van Ooij, N. Luisa Hiller, Manuel Llinás, Bharath Balu, John H. Adams, Kasturi Haldar
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10.1371/journal.ppat.1000214

PLOS Pathogens A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal Antifolates
November 21, 2008 Karthikeyan Ganesan, Napawan Ponmee, Lei Jiang, Joseph W. Fowble, John White, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong, Prapon Wilairat, Pradipsinh K. Rathod
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10.1371/journal.ppat.1000262

PLOS Pathogens Distinct Roles of Plasmodium Rhomboid 1 in Parasite Development and Malaria Pathogenesis
January 16, 2009 Prakash Srinivasan, Isabelle Coppens, Marcelo Jacobs-Lorena
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10.1371/journal.ppat.1000302

PLOS Pathogens The Glutathione Biosynthetic Pathway of Plasmodium Is Essential for Mosquito Transmission
February 20, 2009 Joel Vega-Rodríguez, Blandine Franke-Fayard, Rhoel R. Dinglasan, Chris J. Janse, Rebecca Pastrana-Mena, Andrew P. Waters, Isabelle Coppens, José F. Rodríguez-Orengo, Marcelo Jacobs-Lorena, Adelfa E. Serrano
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10.1371/journal.pntd.0000440

PLOS Neglected Tropical Diseases Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression
August 25, 2009 Solomon Nwaka, Bernadette Ramirez, Reto Brun, Louis Maes, Frank Douglas, Robert Ridley
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10.1371/journal.ppat.1000644

PLOS Pathogens Comparative Transcriptional and Genomic Analysis of Plasmodium falciparum Field Isolates
October 30, 2009 Margaret J. Mackinnon, Jinguang Li, Sachel Mok, Moses M. Kortok, Kevin Marsh, Peter R. Preiser, Zbynek Bozdech
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10.1371/journal.ppat.1000737

PLOS Pathogens Histone Deacetylases Play a Major Role in the Transcriptional Regulation of the Plasmodium falciparum Life Cycle
January 22, 2010 Balbir K. Chaal, Archna P. Gupta, Brigitta D. Wastuwidyaningtyas, Yen-Hoon Luah, Zbynek Bozdech
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10.1371/journal.ppat.1000830

PLOS Pathogens Origin and Evolution of Sulfadoxine Resistant Plasmodium falciparum
March 26, 2010 Sumiti Vinayak, Md Tauqeer Alam, Tonya Mixson-Hayden, Andrea M. McCollum, Rithy Sem, Naman K. Shah, Pharath Lim, Sinuon Muth, William O. Rogers, Thierry Fandeur, John W. Barnwell, Ananias A. Escalante, Chansuda Wongsrichanalai, Frederick Ariey, Steven R. Meshnick, Venkatachalam Udhayakumar
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10.1371/journal.ppat.1000887

PLOS Pathogens Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum
May 13, 2010 Stephanie G. Valderramos, Juan-Carlos Valderramos, Lise Musset, Lisa A. Purcell, Odile Mercereau-Puijalon, Eric Legrand, David A. Fidock
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10.1371/journal.pntd.0001023

PLOS Neglected Tropical Diseases Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads
May 3, 2011 Kenny Ang, Joseline Ratnam, Jiri Gut, Jennifer Legac, Elizabeth Hansell, Zachary Mackey, Katarzyna Skrzypczynska, Anjan Debnath, Juan Engel, Philip Rosenthal, James McKerrow, Michelle Arkin, Adam Renslo
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10.1371/journal.pntd.0001412

PLOS Neglected Tropical Diseases Integrated Dataset of Screening Hits against Multiple Neglected Disease Pathogens
December 20, 2011 Solomon Nwaka, Dominique Besson, Bernadette Ramirez, Louis Maes, An Matheeussen, Quentin Bickle, Nuha Mansour, Fouad Yousif, Simon Townson, Suzanne Gokool, Fidelis Cho-Ngwa, Moses Samje, Shailja Misra-Bhattacharya, P Murthy, Foluke Fakorede, Jean-Marc Paris, Clive Yeates, Robert Ridley, Wesley Van Voorhis, Timothy Geary
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10.1371/journal.pntd.0001625

PLOS Neglected Tropical Diseases Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs
April 24, 2012 Andrew Bell, James Mills, Gareth Williams, James Brannigan, Anthony Wilkinson, Tanya Parkinson, Robin Leatherbarrow, Edward Tate, Anthony Holder, Deborah Smith
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10.1371/journal.pntd.0001772

PLOS Neglected Tropical Diseases An Analytical Method for Assessing Stage-Specific Drug Activity in Plasmodium vivax Malaria: Implications for Ex Vivo Drug Susceptibility Testing
August 7, 2012 Douglas Kerlin, Kane Boyce, Jutta Marfurt, Julie Simpson, Enny Kenangalem, Qin Cheng, Ric Price, Michelle Gatton
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10.1371/journal.ppat.1003170

PLOS Pathogens Dynamic Epigenetic Regulation of Gene Expression during the Life Cycle of Malaria Parasite Plasmodium falciparum
February 28, 2013 Archna Gupta, Wai Chin, Lei Zhu, Sachel Mok, Yen-Hoon Luah, Eng-How Lim, Zbynek Bozdech
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10.1371/journal.pgen.1003293

PLOS Genetics Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families
February 7, 2013 Selina Bopp, Micah Manary, A Bright, Geoffrey Johnston, Neekesh Dharia, Fabio Luna, Susan McCormack, David Plouffe, Case McNamara, John Walker, David Fidock, Eros Lazzerini Denchi, Elizabeth Winzeler
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10.1371/journal.ppat.1003430

PLOS Pathogens DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial Cells
June 27, 2013 Marion Avril, Andrew Brazier, Martin Melcher, Sowmya Sampath, Joe Smith
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10.1371/journal.ppat.1003546

PLOS Pathogens Identification of New PNEPs Indicates a Substantial Non-PEXEL Exportome and Underpins Common Features in Plasmodium falciparum Protein Export
August 8, 2013 Heiber Arlett, Florian Kruse, Christian Pick, Christof Grüring, Sven Flemming, Alexander Oberli, Hanno Schoeler, Silke Retzlaff, Paolo Mesén-Ramírez, Jan Hiss, Madhusudan Kadekoppala, Leonie Hecht, Anthony Holder, Tim-Wolf Gilberger, Tobias Spielmann
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10.1371/journal.ppat.1003488

PLOS Pathogens Asparagine Repeats in Plasmodium falciparum Proteins: Good for Nothing?
August 22, 2013 Vasant Muralidharan, Daniel Goldberg
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10.1371/journal.pntd.0002425

PLOS Neglected Tropical Diseases Neutral Polymorphisms in Putative Housekeeping Genes and Tandem Repeats Unravels the Population Genetics and Evolutionary History of Plasmodium vivax in India
September 19, 2013 Surendra Prajapati, Hema Joshi, Jane Carlton, Moshahid Rizvi
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10.1371/journal.ppat.1003655

PLOS Pathogens The Suf Iron-Sulfur Cluster Synthesis Pathway Is Required for Apicoplast Maintenance in Malaria Parasites
September 26, 2013 Jolyn Gisselberg, Teegan Dellibovi-Ragheb, Krista Matthews, Gundula Bosch, Sean Prigge
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10.1371/journal.ppat.1003782

PLOS Pathogens Real-Time Imaging of the Intracellular Glutathione Redox Potential in the Malaria Parasite Plasmodium falciparum
December 5, 2013 Dennis Kasozi, Franziska Mohring, Stefan Rahlfs, Andreas Meyer, Katja Becker
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10.1371/journal.pgen.1004085

PLOS Genetics Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism
January 2, 2014 Manuel Llinas, Ian Lewis, Mark Wacker, Kellen Olszewski, Simon Cobbold, Katelynn Baska, Asako Tan, Michael Ferdig
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10.1371/journal.ppat.1003854

PLOS Pathogens Recruitment of PfSET2 by RNA Polymerase II to Variant Antigen Encoding Loci Contributes to Antigenic Variation in P. falciparum
January 2, 2014 Uchechi Ukaegbu, Sandeep Kishore, Dacia Kwiatkowski, Chethan Pandarinath, Noa Dahan-Pasternak, Ron Dzikowski, Kirk Deitsch
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10.1371/journal.pntd.0002610

PLOS Neglected Tropical Diseases Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box
January 9, 2014 Katrin Ingram-Sieber, Noemi Cowan, Godana Panic, Mireille Vargas, Nuha Mansour, Quentin Bickle, Timothy Wells, Thomas Spangenberg, Jennifer Keiser
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10.1371/journal.pmed.1001169

PLOS Genetics Evolution of Chloroplast Transcript Processing in Plasmodium and Its Chromerid Algal Relatives
January 16, 2014 Richard Dorrell, James Drew, R Ellen Nisbet, Christopher Howe
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10.1371/journal.ppat.1003876

PLOS Pathogens Phosphoenolpyruvate Carboxylase Identified as a Key Enzyme in Erythrocytic Plasmodium falciparum Carbon Metabolism
January 16, 2014 Janet Storm, Sonal Sethia, Gavin Blackburn, Achuthanunni Chokkathukalam, David Watson, Rainer Breitling, Graham Coombs, Sylke Müller
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10.1371/journal.pntd.0002796

PLOS Neglected Tropical Diseases Differing Patterns of Selection and Geospatial Genetic Diversity within Two Leading Plasmodium vivax Candidate Vaccine Antigens
April 17, 2014 Christian Parobek, Jeffrey Bailey, Nicholas Hathaway, Duong Socheat, William Rogers, Jonathan Juliano
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10.1371/journal.pmed.1001169

PLOS Pathogens Rapid Response to Selection, Competitive Release and Increased Transmission Potential of Artesunate-Selected Plasmodium chabaudi Malaria Parasites
April 24, 2014 Laura Pollitt, Silvie Huijben, Derek Sim, Rahel Salathé, Matt Jones, Andrew Read
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10.1371/journal.pgen.1004382

PLOS Genetics A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum
May 15, 2014 Cecilia Sanchez, Chia-Hao Liu, Sybille Mayer, Astutiati Nurhasanah, Marek Cyrklaff, Jianbing Mu, Michael Ferdig, Wilfred Stein, Michael Lanzer
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10.1371/journal.pntd.0002882

PLOS Neglected Tropical Diseases A High Resolution Case Study of a Patient with Recurrent Plasmodium vivax Infections Shows That Relapses Were Caused by Meiotic Siblings
June 5, 2014 Andrew Bright, Micah Manary, Ryan Tewhey, Eliana Arango, Tina Wang, Nichloas Schork, Stephanie Yanow, Elizabeth Winzeler
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10.1371/journal.pbio.1001898

PLOS Biology Plasmepsin V, a Secret Weapon Against Malaria
July 1, 2014 Caitlin Sedwick
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10.1371/journal.pbio.1001897

PLOS Biology Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites
July 1, 2014 Brad Sleebs, Sash Lopaticki, Danushka Marapana, Matthew O'Neill, Pravin Rajasekaran, Michelle Gazdik, Svenja Gunther, Lachlan Whitehead, Kym Lowes, Lea Barfod, Lars Hviid, Philip Shaw, Anthony Hodder, Brian Smith, Alan Cowman, Justin Boddey
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10.1371/journal.pntd.0003086

PLOS Neglected Tropical Diseases Disease Progression in Plasmodium knowlesi Malaria Is Linked to Variation in Invasion Gene Family Members
August 14, 2014 Atique Ahmed, Miguel Pinheiro, Paul Divis, Angela Siner, Ramlah Zainudin, Ing Wong, Chan Lu, Sarina Singh-Khaira, Scott Millar, Sean Lynch, Matthias Willmann, Balbir Singh, Sanjeev Krishna, Janet Cox-Singh
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10.1371/journal.pntd.0003071

PLOS Neglected Tropical Diseases Is Plasmodium vivax Malaria a Severe Malaria?: A Systematic Review and Meta-Analysis
August 14, 2014 Cho Naing, Maxine A Whittaker, Victor Nyunt Wai, Joon Wah Mak
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10.1371/journal.ppat.1004537

PLOS Pathogens Differential PfEMP1 Expression Is Associated with Cerebral Malaria Pathology
December 4, 2014 Dumizulu Tembo, Benjamin Nyoni, Rekha Murikoli, Mavuto Mukaka, Danny Milner, Matthew Berriman, Stephen Rogerson, Terrie Taylor, Malcolm Molyneux, Wilson Mandala, Alister Craig, Jacqui Montgomery
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10.1371/journal.pgen.1004878

PLOS Genetics How Malaria Parasites Avoid Running Out of Ammo
December 18, 2014 David Arnot
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10.1371/journal.pgen.1004812

PLOS Genetics Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis
December 18, 2014 Antoine Claessens, William Hamilton, Mihir Kekre, Thomas Otto, Adnan Faizullabhoy, Julian Rayner, Dominic Kwiatkowski
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10.1371/journal.pntd.0003413

PLOS Neglected Tropical Diseases Systematic Review of Sub-microscopic P. vivax Infections: Prevalence and Determining Factors
January 8, 2015 Qin Cheng, Jane Cunningham, Michelle Gatton
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10.1371/journal.ppat.1004639

PLOS Pathogens Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress
February 3, 2015 Jeong Joo Kim, Christian Flueck, Eugen Franz, Eduardo Sanabria-Figueroa, Eloise Thompson, Robin Lorenz, Daniela Bertinetti, David Baker, Friedrich Herberg, Choel Kim
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10.1371/journal.ppat.1004628

PLOS Pathogens Within-host Competition Does Not Select for Virulence in Malaria Parasites; Studies with Plasmodium yoelii
February 6, 2015 Hussein Abkallo, Julie-Anne Tangena, Jianxia Tang, Nobuyuki Kobayashi, Megumi Inoue, Augustin Zoungrana, Nick Colegrave, Richard Culleton
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10.1371/journal.pmed.1001788

PLOS Medicine Ultra-Sensitive Detection of Plasmodium falciparum by Amplification of Multi-Copy Subtelomeric Targets
March 3, 2015 Natalie Hofmann, Felista Mwingira, Seif Shekalaghe, Leanne Robinson, Ivo Mueller, Ingrid Felger
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10.1371/journal.ppat.1004789

PLOS Pathogens Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign
April 2, 2015 Eldin Talundzic, Sheila Akinyi Okoth, Kanungnit Congpuong, Mateusz Plucinski, Lindsay Morton, Ira Goldman, Patrick Kachur, Chansuda Wongsrichanalai5, Wichai Satimai, John Barnwell, Venkatachalam Udhayakumar
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10.1371/journal.pntd.0003634

PLOS Neglected Tropical Diseases Plasmodium vivax Populations Are More Genetically Diverse and Less Structured than Sympatric Plasmodium falciparum Populations
April 15, 2015 Charlie Jennison, Alicia Arnott, Natacha Tessier, Livingstone Tavul, Cristian Koepfli, Ingrid Felger, Peter Siba, John Reeder, Melanie Bahlo, Ivo Mueller, Alyssa Barry
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10.1371/journal.pbio.1002132

PLOS Biology Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
April 22, 2015 Con Dogovski, Stanley Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnädig, Judith Straimer, Zbynek Bozdech, David Fidock, Julie Simpson, Arjen Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley

Targeting the parasite: Blood Stages - Sexual stages

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10.1371/journal.pntd.0000804

PLOS Neglected Tropical Diseases Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach
August 24, 2010 Gregory J. Crowther, Dhanasekaran Shanmugam, Santiago J. Carmona, Maria A. Doyle, Christiane Hertz-Fowler, Matthew Berriman, Solomon Nwaka, Stuart A. Ralph, David S. Roos, Wesley C. Van Voorhis, Fernán Agüero
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10.1371/journal.ppat.1002554

PLOS Pathogens A Putative Homologue of CDC20/CDH1 in the Malaria Parasite Is Essential for Male Gamete Development
February 23, 2012 David Guttery, David Ferguson, Benoit Poulin, Zhengyao Xu, Ursula Straschil, Onny Klop, Lev Solyakov, Sara Sandrini, Declan Bradsy, Conrad Nieduszynski, Chris Janse, Anthony Holder, Andrew Tobin, Rita Tewari
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10.1371/journal.ppat.1002964

PLOS Pathogens Plasmodium falciparum Gametocyte Development 1 (Pfgdv1) and Gametocytogenesis Early Gene Identification and Commitment to Sexual Development
October 18, 2012 Saliha Eksi, Belinda Morahan, Yoseph Haile, Tetsuya Furuya, Hongying Jiang, Omar Ali, Huichun Xu, Kirakorn Kiattibutr, Amreena Suri, Beata Czesny, Adebowale Adeyemo, Timothy Myers, Jetsumon Sattabongkot, Xinzhuan Su, Kim Williamson
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10.1371/journal.ppat.1003191

PLOS Pathogens The Plasmodium berghei Ca²⁺/H⁺ Exchanger, PbCAX, Is Essential for Tolerance to Environmental Ca²⁺ during Sexual Development
February 28, 2013 David Guttery, Jon Pittman, Karine Frénal, Benoit Poulin, Leon McFarlane, Ksenija Slavic, Sally Wheatley, Dominique Soldati-Favre, Sanjeev Krishna, Rita Tewari, Henry Staines
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10.1371/journal.ppat.1003268

PLOS Pathogens Puf Mediates Translation Repression of Transmission-Blocking Vaccine Candidates in Malaria Parasites
April 18, 2013 Jun Miao, Qi Fan, Daniel Parker, Xiaolian Li, Jianyong Li, Liwang Cui

Targeting the parasite: All blood (asexual and sexual) stages

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10.1371/journal.ppat.1002015

PLOS Pathogens Plasmodium knowlesi: Reservoir Hosts and Tracking the Emergence in Humans and Macaques
April 7, 2011 Kim-Sung Lee, Paul Divis, Siti Zakaria, Asmad Matusop, Roynston Julin, David Conway, Janet Cox-Singh, Balbir Singh
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10.1371/journal.pcbi.1003257

PLOS Computational Biology Prediction of the P. falciparum Target Space Relevant to Malaria Drug Discovery
October 17, 2013 Andreas Spitzmüller, Jordi Mestres
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10.1371/journal.pcbi.1003392

PLOS Computational Biology Inferring Developmental Stage Composition from Gene Expression in Human Malaria
December 12, 2013 Regina Joice, Vagheesh Narasimhan, Jacqui Montgomery, Amar Bir Sidhu, Keunyoung Oh, Evan Meyer, Willythssa Pierre-Louis, Karl Seydel, Danny Milner, Kim Williamson, Roger Wiegand, Daouda Ndiaye, Johanna Daily, Dyann Wirth, Terrie Taylor, Curtis Huttenhower, Matthias Marti
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10.1371/journal.pntd.0003453

PLOS Neglected Tropical Diseases Evaluation of the Loop Mediated Isothermal DNA Amplification (LAMP) Kit for Malaria Diagnosis in P. vivax Endemic Settings of Colombia
January 8, 2015 Andres Vallejo, Nora Martínez, Iveth González, Myriam Arévalo-Herrera, Socrates Herrera
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10.1371/journal.pntd.0003377

PLOS Neglected Tropical Diseases From Bright Ideas to Tools: The Case of Malaria
January 8, 2015 Melba Gomes, Annette Kuesel
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10.1371/journal.pntd.0003566

PLOS Neglected Tropical Diseases Comparative Analysis of Field-Isolate and Monkey-Adapted Plasmodium vivax Genomes
March 13, 2015 Ernest Chan, John Barnwell, Peter Zimmerman, David Serre
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10.1371/journal.pntd.0003595

PLOS Neglected Tropical Diseases Modeling the Dynamics of Plasmodium vivax Infection and Hypnozoite Reactivation In Vivo
March 17, 2015 Adeshina Adekunle, Mykola Pinkevych, Rose McGready, Christine Luxemburger, Lisa White, François Nosten, Deborah Cromer, Miles Davenport
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10.1371/journal.pntd.0003539

PLOS Neglected Tropical Diseases Development of a Single Nucleotide Polymorphism Barcode to Genotype Plasmodium vivax Infections
March 17, 2015 Mary Lynn Baniecki, Aubrey Faust, Stephen Schaffner, Daniel Park, Kevin Galinsky, Rachel Daniels, Elizabeth Hamilton, Marcelo Ferreira, Nadira Karunaweera, David Serre, Peter Zimmerman, Thomas Wellems, Juliana Sá, Lise Musset, Eric Legrand, Alexandre Melnikov, Daniel Neafsey, Sarah Volkman, Dyann Wirth, Pardis Sabeti
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10.1371/journal.pntd.0000653

PLOS Neglected Tropical Diseases A Systems-Based Analysis of Plasmodium vivax Lifecycle Transcription from Human to Mosquito
April 6, 2010 Scott J. Westenberger, Colleen M. McClean, Rana Chattopadhyay, Neekesh V. Dharia, Jane M. Carlton, John W. Barnwell, William E. Collins, Stephen L. Hoffman, Yingyao Zhou, Joseph M. Vinetz, Elizabeth A. Winzeler

Targeting the parasite: Liver Stages

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10.1371/journal.ppat.1002178

PLOS Pathogens The Next Opportunity in Anti-Malaria Drug Discovery: The Liver Stage
September 22, 2011 Emily Derbyshire, Maria Mota, Jon Clardy
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10.1371/journal.ppat.1004336

PLOS Pathogens A Cysteine Protease Inhibitor of Plasmodium berghei Is Essential for Exo-erythrocytic Development
August 28, 2014 Christine Lehmann, Anna Heitmann, Satish Mishra, Paul-Christian Burda, Mirko Singer, Monica Prado, Livia Niklaus, Céline Lacroix, Robert Ménard, Friedrich Frischknecht, Rebecca Stanway, Photini Sinnis, Volker Heussler
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10.1371/journal.pntd.0003268

PLOS Neglected Tropical Diseases Protective Efficacy of a Plasmodium vivax Circumsporozoite Protein-Based Vaccine in Aotus nancymaae Is Associated with Antibodies to the Repeat Region
October 16, 2014 Anjali Yadava, Cysha Hall, JoAnn Sullivan, Douglas Nace, Tyronne Williams, William Collins, Christian Ockenhouse, John Barnwell
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10.1371/journal.ppat.1004760

PLOS Pathogens A Plasmodium Phospholipase Is Involved in Disruption of the Liver Stage Parasitophorous Vacuole Membrane
March 18, 2015 Paul-Christian Burda, Matthias Roelli, Marco Schaffner, Shahid Khan, Chris Janse, Volker Heussler
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10.1371/journal.ppat.1002224

PLOS Pathogens Hostile Takeover by Plasmodium: Reorganization of Parasite and Host Cell Membranes during Liver Stage Egress
September 1, 2011 Stefanie Graewe, Kathleen Rankin, Christine Lehmann, Christina Deschermeier, Leonie Hecht, Ulrike Froehlke, Rebecca Stanway, Volker Heussler

Targeting the parasite: Insect Stage

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10.1371/journal.ppat.0010009

PLOS Pathogens Exit of Plasmodium Sporozoites from Oocysts Is an Active Process That Involves the Circumsporozoite Protein
September 30, 2005 Qian Wang, Hisashi Fujioka, Victor Nussenzweig
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10.1371/journal.ppat.1000195

PLOS Pathogens Proteomic Profiling of Plasmodium Sporozoite Maturation Identifies New Proteins Essential for Parasite Development and Infectivity
October 31, 2008 Edwin Lasonder, Chris J. Janse, Geert-Jan van Gemert, Gunnar R. Mair, Adriaan M. W. Vermunt, Bruno G. Douradinha, Vera van Noort, Martijn A. Huynen, Adrian J. F. Luty, Hans Kroeze, Shahid M. Khan, Robert W. Sauerwein, Andrew P. Waters, Matthias Mann, Hendrik G. Stunnenberg
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10.1371/journal.ppat.1000767

PLOS Pathogens Universal Features of Post-Transcriptional Gene Regulation Are Critical for Plasmodium Zygote Development
February 12, 2010 Gunnar R. Mair, Edwin Lasonder, Lindsey S. Garver, Blandine M. D. Franke-Fayard, Céline K. Carret, Joop C. A. G. Wiegant, Roeland W. Dirks, George Dimopoulos, Chris J. Janse, Andrew P. Waters
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10.1371/journal.ppat.1000825

PLOS Pathogens Exoerythrocytic Plasmodium Parasites Secrete a Cysteine Protease Inhibitor Involved in Sporozoite Invasion and Capable of Blocking Cell Death of Host Hepatocytes
March 26, 2010 Annika Rennenberg, Christine Lehmann, Anna Heitmann, Tina Witt, Guido Hansen, Krishna Nagarajan, Christina Deschermeier, Vito Turk, Rolf Hilgenfeld, Volker T. Heussler
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10.1371/journal.ppat.1002404

PLOS Pathogens Sexual Development in Plasmodium: Lessons from Functional Analyses
January 19, 2012 David Guttery, Anthony Holder, Rita Tewari
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10.1371/journal.ppat.1002725

PLOS Pathogens Shedding of TRAP by a Rhomboid Protease from the Malaria Sporozoite Surface Is Essential for Gliding Motility and Sporozoite Infectivity
July 26, 2012 Ijeoma Ejigiri, Daniel Ragheb, Paco Pino, Alida Coppi, Brandy Bennett, Dominique Soldati-Favre, Photini Sinnis
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10.1371/journal.ppat.1002948

PLOS Pathogens A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion
September 20, 2012 David Guttery, Benoit Poulin, David Ferguson, Balázs Szöőr, Bill Wickstead, Paula Carroll, Chandra Ramakrishnan, Declan Brady, Eva-Maria Patzewitz, Ursula Straschil, Lev Solyakov, Judith Green, Robert Sinden, Andrew Tobin, Anthony Holder, Rita Tewari
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10.1371/journal.ppat.1003136

PLOS Pathogens Expression of Cytosolic Peroxiredoxins in Plasmodium berghei Ookinetes Is Regulated by Environmental Factors in the Mosquito Bloodmeal
January 31, 2013 Benjamin Turturice, Michael Lamm, James Tasch, Angelika Zalewski, Rachel Kooistra, Eric Schroeter, Sapna Sharma, Shin-Ichiro Kawazu, Stefan Kanzok
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10.1371/journal.pcbi.1003025

PLOS Computational Biology Malaria’s Missing Number: Calculating the Human Component of R0 by a Within-Host Mechanistic Model of Plasmodium falciparum Infection and Transmission
April 18, 2013 Geoffrey Johnston, David Smith, David Fidock
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10.1371/journal.ppat.1003522

PLOS Pathogens Malaria Parasite-Synthesized Heme Is Essential in the Mosquito and Liver Stages and Complements Host Heme in the Blood Stages of Infection
August 1, 2013 Viswanathan Nagaraj, Balamurugan Sundaram, Nandan Varadarajan, Pradeep Subramani, Devaiah Kalappa, Susanta Ghosh, Govindarajan Padmanaban
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10.1371/journal.pcbi.1003268

PLOS Computational Biology A Network Approach to Analyzing Highly Recombinant Malaria Parasite Genes
October 10, 2013 Daniel Larremore, Aaron Clauset, Caroline Buckee
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10.1371/journal.ppat.1003790

PLOS Pathogens Killer Bee Molecules: Antimicrobial Peptides as Effector Molecules to Target Sporogonic Stages of Plasmodium
November 21, 2013 Mamadou Coulibaly, Sekou Traore, Frederic Tripet, Paul Eggleston, Hilary Hurd, Victoria Carter, Ann Underhill, Ibrahima Baber, Lakamy Sylla, Mounirou Baby, Isabelle Larget-Thiery, Agnès Zettor, Catherine Bourgouin, Ülo Langel, Ingrid Faye, Laszlo Otvos, John Wade
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10.1371/journal.ppat.1003757

PLOS Pathogens A Small Molecule Glycosaminoglycan Mimetic Blocks Plasmodium Invasion of the Mosquito Midgut
November 21, 2013 Derrick Mathias, Rebecca Pastrana-Mena, Elisabetta Ranucci, Dingyin Tao, Paolo Ferruti, Corrie Ortega, Gregory Staples, Joseph Zaia, Eizo Takashima, Takafumi Tsuboi, Natalie Borg, Luisella Verotta, Rhoel Dinglasan
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10.1371/journal.pmed.1001169

PLOS Computational Biology Modeling Within-Host Effects of Drugs on Plasmodium falciparum Transmission and Prospects for Malaria Elimination
January 23, 2014 Geoffrey Johnston, Peter Gething, Simon Hay, David Smith, David Fidock
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10.1371/journal.pbio.1001806

PLOS Biology Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca²⁺ Signals at Key Decision Points in the Life Cycle of Malaria Parasites
March 4, 2014 Mathieu Brochet, Mark Collins, Terry Smith, Eloise Thompson, Sarah Sebastian, Katrin Volkmann, Frank Schwach, Lia Chappell, Ana Rita Gomes, Matthew Berriman, Julian Rayner, David Baker, Jyoti Choudhary, Oliver Billker
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10.1371/journal.pcbi.1003812

PLOS Computational Biology Seasonally Dependent Relationships between Indicators of Malaria Transmission and Disease Provided by Mathematical Model Simulations
September 4, 2014 Erin Stuckey, Thomas Smith, Nakul Chitnis
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10.1371/journal.ppat.1004308

PLOS Pathogens Evolution of Plastic Transmission Strategies in Avian Malaria
September 11, 2014 Stéphane Cornet, Antoine Nicot, Ana Rivero, Sylvain Gandon
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10.1371/journal.ppat.1004398

PLOS Pathogens Chromobacterium Csp_P Reduces Malaria and Dengue Infection in Vector Mosquitoes and Has Entomopathogenic and In Vitro Anti-pathogen Activities
October 23, 2014 Jose Ramirez, Sarah Short, Ana Bahia, Raúl Saraiva, Yuemei Dong, Seokyoung Kang, Abhai Tripathi, Godfree Mlambo, George Dimopoulos

Targeting the host: Human/Mammal

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10.1371/journal.pmed.0020315

PLOS Medicine Targeting of Endothelial Activation in Cerebral Malaria
August 23, 2005 Editor Synopsis
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10.1371/journal.pmed.0030528

PLOS Medicine Erythrocyte G Protein as a Novel Target for Malarial Chemotherapy
December 26, 2006 Sean C Murphy, Travis Harrison, Heidi E Hamm, Jon W Lomasney, Narla Mohandas, Kasturi Haldar
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10.1371/journal.ppat.1000201

PLOS Pathogens Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection
November 7, 2008 Miguel Prudêncio, Cristina D. Rodrigues, Michael Hannus, Cécilie Martin, Eliana Real, Lígia A. Gonçalves, Céline Carret, Robert Dorkin, Ingo Röhl, Kerstin Jahn-Hoffmann, Adrian J. F. Luty, Robert Sauerwein, Christophe J. Echeverri, Maria M. Mota
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10.1371/journal.ppat.1000559

PLOS Pathogens Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases
August 21, 2009 Marina Tiemi Shio, Stephanie C. Eisenbarth, Myriam Savaria, Adrien F. Vinet, Marie-Josée Bellemare, Kenneth W. Harder, Fayyaz S. Sutterwala, D. Scott Bohle, Albert Descoteaux, Richard A. Flavell, Martin Olivier
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10.1371/journal.ppat.1000963

PLOS Pathogens Cognitive Dysfunction Is Sustained after Rescue Therapy in Experimental Cerebral Malaria, and Is Reduced by Additive Antioxidant Therapy
June 24, 2010 Patricia A. Reis, Clarissa M. Comim, Fernanda Hermani, Bruno Silva, Tatiana Barichello, Aline C. Portella, Flavia C. A. Gomes, Ive M. Sab, Valber S. Frutuoso, Marcus F. Oliveira, Patricia T. Bozza, Fernando A. Bozza, Felipe Dal-Pizzol, Guy A. Zimmerman, João Quevedo, Hugo C. Castro-Faria-Neto
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10.1371/journal.ppat.1003099

PLOS Pathogens Statins Decrease Neuroinflammation and Prevent Cognitive Impairment after Cerebral Malaria
December 27, 2012 Patricia Reis, Vanessa Estato, Tathiany Silva, Joana d'Ávila, Luciana Siqueira, Edson Assis, Patricia Bozza, Fernando Bozza, Eduardo Tibiriçá, Guy Zimmerman, Hugo Castro-Faria-Neto
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10.1371/journal.ppat.1003154

PLOS Pathogens Intravital Placenta Imaging Reveals Microcirculatory Dynamics Impact on Sequestration and Phagocytosis of Plasmodium-Infected Erythrocytes
January 31, 2013 Luciana Moares, Carlos Tadokoro, David Olivieri, Ivan Gomez-Conde, Carlos Penha-Goncalves
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10.1371/journal.ppat.1003153

PLOS Pathogens Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport
February 7, 2013 Philippe Boeuf, Elizabeth Aitken, Upeksha Chandrasiri, Caroline Chua, Bernie McInerney, Leon McQuade, Michael Duffy, Malcolm Molyneux, Graham Brown, Jocelyn Glazier, Stephen Rogerson
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10.1371/journal.pntd.0002071

PLOS Neglected Tropical Diseases Placental Histopathological Changes Associated with Plasmodium vivax Infection during Pregnancy
February 14, 2013 Rodrigo Souza, Ricardo Ataíde, Jamille Dombrowski, Vanessa Ippólito, Elizabeth Aitken, Suiane Valle, José Álvarez, Sabrina Epiphânio, Claudio Marinho
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10.1371/journal.pntd.0002155

PLOS Neglected Tropical Diseases Rosetting in Plasmodium vivax: A Cytoadhesion Phenotype Associated with Anaemia
April 4, 2013 Alejandro Marín-Menéndez, Azucena Bardají, Flor Martínez-Espinosa, Camila Bôtto-Menezes, Marcus Lacerda, Jon Ortiz, Pau Cisteró, Mireia Piqueras, Ingrid Felger, Ivo Mueller, Jaume Ordi, Hernando del Portillo, Clara Menéndez, Mats Wahlgren, Alfredo Mayor
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10.1371/journal.ppat.1003293

PLOS Pathogens IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals
April 11, 2013 Ana Villegas-Mendez, J. Brian de Souza, Seen-Wai Lavelle, Emily Gwyer Findlay, Tovah Shaw, Nico van Rooijen, Christiaan Saris, Christopher Hunter, Eleanor Riley, Kevin Couper
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10.1371/journal.ppat.1003303

PLOS Pathogens Identification of Targets of CD8⁺ T Cell Responses to Malaria Liver Stages by Genome-wide Epitope Profiling
May 9, 2013 Julius Hafalla, Karolis Bauza, Johannes Friesen, Gloria Gonzalez-Aseguinolaza, Adrian V. S. Hill, Kai Matuschewski
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10.1371/journal.pgen.1003509

PLOS Genetics Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations
May 23, 2013 Gavin Band, Quang Le, Luke Jostins, Matti Pirinen, Katja Kivinen, Muminatou Jallow, Fatoumatta Sisay-Joof, Kalifa Bojang, Margaret Pinder, Giorgio Sirugo, David Conway, Vysaul Nyirongo, David Kachala, Malcolm Molyneux, Terrie Taylor, Carolyne Ndila, Norbert Peshu, Kevin Marsh, Thomas Williams, Daniel Alcock, Robert Andrews, Sarah Edkins, Emma Gray, Christina Hubbart, Anna Jeffreys, Kate Rowlands, Kathrin Schuldt, Taane Clark, Kerrin Small, Yik Teo, Dominic Kwiatowski, Kirk Rockett, Jeffrey Barrett, Chris Spencer, Malaria Genomic Epidemiological Network (MalariaGEN)
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10.1371/journal.ppat.1003406

PLOS Pathogens Extramedullary Myelopoiesis in Malaria Depends on Mobilization of Myeloid-Restricted Progenitors by IFN-γ Induced Chemokines
June 6, 2013 Nikolai Belyaev, Judit Biro, Jean Langhorne, Alexandre Potocnik
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10.1371/journal.ppat.1003444

PLOS Pathogens Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria
June 20, 2013 Peng Kai Ong, Benoît Melchior, Yuri Martins, Anthony Hofer, Pamela Orjuela-Sánchez, Pedro Cabrales, Graziela Zanini, John Frangos, Leonardo Carvalho
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10.1371/journal.ppat.1003491

PLOS Pathogens Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral Malaria
July 11, 2013 Joanne Berghout, David Langlais, Irena Radovanovic, Mifong Tam, John MacMicking, Mary Stevenson, Philippe Gros
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10.1371/journal.pntd.0002324

PLOS Neglected Tropical Diseases Etiology of Severe Non-malaria Febrile Illness in Northern Tanzania: A Prospective Cohort Study
July 18, 2013 John Crump, Anne Morrissey, William Nicholson, Robert Massung, Robyn Stoddard, Renee Galloway, Eng Eong Ooi, Venance Maro, Wilbrod Saganda, Grace Kinabo, Charles Muiruri, John Bartlett
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10.1371/journal.pntd.0002403

PLOS Neglected Tropical Diseases A High Force of Plasmodium vivax Blood-Stage Infection Drives the Rapid Acquisition of Immunity in Papua New Guinean Children
September 5, 2013 Cristian Koepfli, Kathryn Colborn, Benson Kiniboro, Enmoore Lin, Terence Speed, Peter Siba, Ingrid Felger, Ivo Mueller
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10.1371/journal.ppat.1003590

PLOS Pathogens CD36 Recruits α₅β₁ Integrin to Promote Cytoadherence of P. falciparum-Infected Erythrocytes
August 29, 2013 Shevaun Davis, Kristine Lee, Mark Gillrie, Lina Roa, Matthias Amrein, May Ho
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10.1371/journal.pmed.1001169

PLOS Medicine Malaria and Severe Anemia: Thinking beyond Plasmodium falciparum
December 17, 2013 Roly Gosling, Michelle Hsiang
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10.1371/journal.pmed.1001575

PLOS Medicine Major Burden of Severe Anemia from Non-Falciparum Malaria Species in Southern Papua: A Hospital-Based Surveillance Study
December 17, 2013 Nicholas Douglas, Daniel Lampah, Enny Kenangalem, Julie Simpson, Jeanne Poespoprodjo, Paulus Sugiarto, Nicholas Anstey, Ric Price
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10.1371/journal.ppat.1003864

PLOS Pathogens IFNγ/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children
January 9, 2014 Prasanna Jagannathan, Ijeoma Eccles-James, Katherine Bowen, Felistas Nankya, Ann Auma, Samuel Wamala, Charles Ebusu, Mary Muhindo, Emmanuel Arinaitwe, Jessica Briggs, Bryan Greenhouse, Jordan Tappero, Moses Kamya, Grant Dorsey, Margaret Feeney
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10.1371/journal.ppat.1003885

PLOS Pathogens Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection
January 16, 2014 Marco Ataide, Warrison Andrade, Dario Zamboni, Donghai Wang, Maria do Carmo Souza, Bernardo Franklin, Samir Elian, Flaviano Martin, Dhelio Pereira, George Reed, Katherine Fitzgerald, Douglas Golenbock, Ricardo Gazzinelli
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10.1371/journal.pcbi.1003416

PLOS Computational Biology Immune-Mediated Competition in Rodent Malaria Is Most Likely Caused by Induced Changes in Innate Immune Clearance of Merozoites
January 23, 2014 Jayanthi Santhanam, Lars Raberg, Andrew Read, Nicholas Savill
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10.1371/journal.ppat.1003980

PLOS Pathogens PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria
March 6, 2014 Lena Serghides, Chloe McDonald, Ziyue Lu, Miriam Friedel, Cheryl Cui, Keith Ho, Howard Mount, John Sled, Kevin Kain
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10.1371/journal.ppat.1003839

PLOS Pathogens Production, Fate and Pathogenicity of Plasma Microparticles in Murine Cerebral Malaria
March 20, 2014 Fatima El-Assaad, Julie Wheway, Nicholas Hunt, Valery Combes, Georges Grau
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10.1371/journal.ppat.1004038

PLOS Pathogens Affinity Proteomics Reveals Elevated Muscle Proteins in Plasma of Children with Cerebral Malaria
April 17, 2014 Julie Bachmann, Florence Burté, Setia Pramana, Ianina Conte, Biobele Brown, Adebola Orimadegun, Wasiu Ajetunmobi, Nathaniel Afolabi, Francis Akinkunmi, Samuel Omokhodion, Felix Akinbami, Wuraola Shokunbi, Caroline Kampf, Yudi Pawitan, Mathias Uhlén, Olugbemiro Sodeinde, Jochen Schwenk, Mats Wahlgren, Delmiro Fernandez-Reyes, Peter Nilsson
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10.1371/journal.ppat.1004079

PLOS Pathogens Exposure-Dependent Control of Malaria-Induced Inflammation in Children
April 17, 2014 Silvia Portugal, Jacqueline Moebius, Jeff Skinner, Safiatou Doumbo, Didier Doumtabe, Youssounou Kone, Seydou Dia, Kishore Kanakabandi, Daniel Sturdevant, Kimmo Virtaneva, Stephen Porcella, Shanping Li, Ogobara Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Peter Crompton
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10.1371/journal.ppat.1004135

PLOS Pathogens CD8⁺ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria
May 22, 2014 Lei-Shong Lau, Daniel Fernandez Ruiz, Vanessa Mollard, Angelika Sturm, Michelle Neller, Anton Cozijnsen, Julia Gregory et al
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10.1371/journal.ppat.1004236

PLOS Pathogens Real-Time Imaging Reveals the Dynamics of Leukocyte Behaviour during Experimental Cerebral Malaria Pathogenesis
July 17, 2014 Saparna Pai, Jim Qin, Lois Cavanagh, Andrew Mitchell, Fatima El-Assaad, Rohit Jain, Valery Combes, Nicholas Hunt, Georges Grau, Wolfgang Weninger
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10.1371/journal.pmed.1001688

PLOS Medicine Women’s Access and Provider Practices for the Case Management of Malaria during Pregnancy: A Systematic Review and Meta-Analysis
August 5, 2014 Jenny Hill, Lauren D'Mello-Guyett, Jenna Hoyt, Anna M. van Eijk, Feiko O. ter Kuile, Jayne Webster
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10.1371/journal.ppat.1004393

PLOS Pathogens The CD14⁺CD16⁺ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria
September 18, 2014 Lis Antonelli, Fabiana Leoratti, Pedro Costa, Bruno Rocha, Suelen Diniz, Mauro Tada, Dhelio Pereira, Andrea Teixeira-Carvalho, Douglas Golenbock, Ricardo Gonçalves, RICARDO GAZZINELLI
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10.1371/journal.ppat.1004528

PLOS Pathogens Experimental Cerebral Malaria Pathogenesis—Hemodynamics at the Blood Brain Barrier
December 4, 2014 Adela Nacer, Alexandru Movila, Fabien Sohet, Natasha Girgis, Uma Mahesh Gundra, P'ng Loke, Richard Daneman, Ute Frevert
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10.1371/journal.ppat.1004558

PLOS Pathogens Parasite Biomass-Related Inflammation, Endothelial Activation, Microvascular Dysfunction and Disease Severity in Vivax Malaria
January 8, 2015 Bridget Barber, Timothy William, Matthew Grigg, Uma Parameswaran, Kim Piera, Ric Price, Tsin Yeo, Nicholas Anstey
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10.1371/journal.ppat.1004637

PLOS Pathogens Lymph-Node Resident CD8α⁺ Dendritic Cells Capture Antigens from Migratory Malaria Sporozoites and Induce CD8⁺ T Cell Responses
February 6, 2015 Andrea Radtke, Wolfgang Kastenmüller, Diego Espinosa, Michael Gerner, Sze-Wah Tse, Photini Sinnis, Ronald Germain, Fidel Zavala, Ian Cockburn
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10.1371/journal.ppat.1004598

PLOS Pathogens In Vivo Approaches Reveal a Key Role for DCs in CD4+ T Cell Activation and Parasite Clearance during the Acute Phase of Experimental Blood-Stage Malaria
February 6, 2015 Henrique Borges da Silva, Raíssa Fonseca, Alexandra Cassado, Érika Machado de Salles, Maria de Menezes, Jean Langhorne, Katia Perez, Iolanda Cuccovia, Bernhard Ryffel, Vasco Barreto, Claudio Marinho, Silvia Boscardin, José Álvarez, Maria D'Império Lima, Carlos Tadokoro
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10.1371/journal.ppat.1004607

PLOS Pathogens IL-33-Mediated Protection against Experimental Cerebral Malaria Is Linked to Induction of Type 2 Innate Lymphoid Cells, M2 Macrophages and Regulatory T Cells
February 6, 2015 Anne-Gaelle Besnard, Rodrigo Guabiraba, Wanda Niedbala, Jennifer Palomo, Flora Reverchon, Tovah Shaw, Kevin Couper, Bernhard Ryffel, Foo Liew
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10.1371/journal.ppat.1004631

PLOS Pathogens Cytoplasmic Actin Is an Extracellular Insect Immune Factor which Is Secreted upon Immune Challenge and Mediates Phagocytosis and Direct Killing of Bacteria, and Is a Plasmodium Antagonist
February 6, 2015 Simone Sandiford, Yuemei Dong, Andrew Pike, Benjamin Blumberg, Ana Bahia, George Dimopoulos
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10.1371/journal.pgen.1004960

PLOS Genetics African Glucose-6-Phosphate Dehydrogenase Alleles Associated with Protection from Severe Malaria in Heterozygous Females in Tanzania
February 11, 2015 Alphaxard Manjurano, Nuno Sepulveda, Behzad Nadjm, George Mtove, Hannah Wangai, Caroline Maxwell, Raimos Olomi, Hugh Reyburn, Eleanor Riley, Chris Drakeley, Taane Clark, MalariaGEN MalariaGEN
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10.1371/journal.pntd.0003602

PLOS Neglected Tropical Diseases G6PD Deficiency at Sumba in Eastern Indonesia Is Prevalent, Diverse and Severe: Implications for Primaquine Therapy against Relapsing Vivax Malaria
March 6, 2015 Ari Satyagraha, Arkasha Sadhewa, Vanessa Baramuli, Rosalie Elvira, Chase Ridenour, Iqbal Elyazar, Rintis Noviyanti, Farah Coutrier, Alida Harahap, J. Kevin Baird
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10.1371/journal.ppat.1004655

PLOS Pathogens Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Oxidized Biopterins in Pediatric Falciparum Malaria: Association with Disease Severity
March 12, 2015 Matthew Rubach, Jackson Mukemba, Salvatore Florence, Bert Lopansri, Keith Hyland, Alicia Volkheimer, Tsin Yeo, Nicholas Anstey, J. Brice Weinberg, Esther Mwaikambo, Donald Granger
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10.1371/journal.ppat.1004667

PLOS Pathogens Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Dihydrobiopterin in Adult Falciparum Malaria: Association with Disease Severity, Impaired Microvascular Function and Increased Endothelial Activation
March 12, 2015 Tsin Yeo, Daniel Lampah, Enny Kenangalem, Emiliana Tjitra, Ric Price, J Weinberg, Keith Hyland, Donald Granger, Nicholas Anstey
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10.1371/journal.ppat.1004715

PLOS Pathogens Disruption of IL-21 Signaling Affects T Cell-B Cell Interactions and Abrogates Protective Humoral Immunity to Malaria
March 12, 2015 Damián Pérez-Mazliah, Dorothy Ng, Ana Freitas do Rosário, Sarah McLaughlin, Béatris Mastelic-Gavillet, Jan Sodenkamp, Garikai Kushinga, Jean Langhorne

Targeting the host: Vector

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10.1371/journal.ppat.1000366

PLOS Pathogens MAPK ERK Signaling Regulates the TGF-β1-Dependent Mosquito Response to Plasmodium falciparum
April 3, 2009 Win Surachetpong, Naresh Singh, Kong Wai Cheung, Shirley Luckhart
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10.1371/journal.ppat.1001003

PLOS Pathogens Activation of Akt Signaling Reduces the Prevalence and Intensity of Malaria Parasite Infection and Lifespan in Anopheles stephensi Mosquitoes
July 15, 2010 Vanessa Corby-Harris, Anna Drexler, Laurel Watkins de Jong, Yevgeniya Antonova, Nazzy Pakpour, Rolf Ziegler, Frank Ramberg, Edwin E. Lewis, Jessica M. Brown, Shirley Luckhart, Michael A. Riehle
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10.1371/journal.pntd.0001317

PLOS Neglected Tropical Diseases The JAK-STAT Pathway Controls Plasmodium vivax Load in Early Stages of Anopheles aquasalis Infection
November 1, 2011 Ana Bahia, Marina Kubota, Antonio Tempone, Helena Araújo, Bruno Guedes, Alessandra Orfanó, Wanderli Tadei, Claudia Ríos-Velásquez, Yeon Han, Nágila Secundino, Carolina Barillas-Mury, Paulo Pimenta, Yara Traub-Cseko
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10.1371/journal.ppat.1002948

PLOS Pathogens A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion
September 20, 2012 David Guttery, Benoit Poulin, David Ferguson, Balázs Szöőr, Bill Wickstead, Paula Carroll, Chandra Ramakrishnan, Declan Brady, Eva-Maria Patzewitz, Ursula Straschil, Lev Solyakov, Judith Green, Robert Sinden, Andrew Tobin, Anthony Holder, Rita Tewari
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10.1371/journal.ppat.1003180

PLOS Pathogens Sustained Activation of Akt Elicits Mitochondrial Dysfunction to Block Plasmodium falciparum Infection in the Mosquito Host
February 28, 2013 Shirley Luckhart, Cecilia Giulivi, Anna Drexler, Yevgeniya Antonova-Koch, Danielle Sakaguchi, Eleonora Napoli, Sarah Wong, Mark Price, Richard Eigenheer, Brett Phinney, Nazzy Pakpour, Jose Pietri, Kong Cheung, Martha Georgis, Michael Riehle
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10.1371/journal.ppat.1003145

PLOS Pathogens Comprehensive Genetic Dissection of the Hemocyte Immune Response in the Malaria Mosquito Anopheles gambiae
January 31, 2013 Fabrizio Lombardo, Yasmeen Ghani, Fotis Kafatos, George Christophides
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10.1371/journal.pntd.0002139

PLOS Neglected Tropical Diseases Biodiversity Can Help Prevent Malaria Outbreaks in Tropical Forests
March 21, 2013 Gabriel Laporta, Paulo Inácio Prado, Roberto Kraenkal, Renato Coutinho, Maria Anice Sallum
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10.1371/journal.ppat.1003365

PLOS Pathogens Non-Genetic Determinants of Mosquito Competence for Malaria Parasites
June 20, 2013 Thierry Lefèvre, Amelie Vantaux, Kounbobr Dabire, Karine Mouline, Anna Cohuet
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10.1371/journal.ppat.1003623

PLOS Pathogens The CLIP-Domain Serine Protease Homolog SPCLIP1 Regulates Complement Recruitment to Microbial Surfaces in the Malaria Mosquito Anopheles gambiae
September 5, 2013 Michael Povelones, Lavanya Bhagavatula, Hassan Yassine, Lee Aun Tan, Leanna Upton, Mike Osta, George Christophides
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10.1371/journal.ppat.1003622

PLOS Pathogens The JNK Pathway Is a Key Mediator of Anopheles gambiae Antiplasmodial Immunity
September 5, 2013 Lindsey Garver, Giselle Oliveira, Carolina Barillas-Mury
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10.1371/journal.ppat.1003602

PLOS Pathogens Chemicals, Climate, and Control: Increasing the Effectiveness of Malaria Vector Control Tools by Considering Relevant Temperatures
October 3, 2013 Katey Glunt, Justine Blanford, Krijn Paaijmans
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10.1371/journal.pbio.1001694

PLOS Biology His Hormone, Her Oogenesis: How Male Malaria Mosquitoes Trigger Female Egg Development
October 29, 2013 Richard Robinson
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10.1371/journal.pbio.1001695

PLOS Biology The Interaction between a Sexually Transferred Steroid Hormone and a Female Protein Regulates Oogenesis in the Malaria Mosquito Anopheles gambiae
October 29, 2013 Francesco Baldini, Paolo Gabrieli, Adam South, Clarissa Valim, Francesca Mancini, Flaminia Catteruccia
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10.1371/journal.pntd.0002682

PLOS Neglected Tropical Diseases Inferring Plasmodium vivax Transmission Networks from Tempo-Spatial Surveillance Data
February 6, 2014 Benyun Shi, Jiming Liu, Xiao-Nong Zhou, Guo-Jing Yang
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10.1371/journal.ppat.1003897

PLOS Pathogens Genetic Dissection of Anopheles gambiae Gut Epithelial Responses to Serratia marcescens
March 6, 2014 Stavros Stathopoulos, Daniel Neafsey, Mara Lawniczak, Marc Muskavitch, George Christophides
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10.1371/journal.pgen.1004236

PLOS Genetics CYP6 P450 Enzymes and ACE-1 Duplication Produce Extreme and Multiple Insecticide Resistance in the Malaria Mosquito Anopheles gambiae
March 20, 2014 Constant Edi, Luc Djogbenou, Adam Jenkins, Kimberly Regna, Marc Muskavitch, Rodolphe Poupardin, Christopher Jones, John Essandoh, Guillaume Kétoh, Mark Paine, Benjamin Koudou, Martin Donnelly, Hilary Ranson, David Weetman
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10.1371/journal.pmed.1001630

PLOS Medicine Indoor Residual Spraying in Combination with Insecticide-Treated Nets Compared to Insecticide-Treated Nets Alone for Protection against Malaria: A Cluster Randomised Trial in Tanzania
April 15, 2014 Philippa West, Natacha Protopopoff, Alexandra Wright, Zuhura Kivaju, Robinson Tigererwa, Franklin Mosha, William Kisinza, Mark Rowland, Immo Kleinschmidt
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10.1371/journal.pntd.0002889

PLOS Neglected Tropical Diseases Multiple Resistances and Complex Mechanisms of Anopheles sinensis Mosquito: A Major Obstacle to Mosquito-Borne Diseases Control and Elimination in China
May 22, 2014 Xuelian Chang, Daibin Zhong, Qiang Fang, Joshua Hartsel, Guofa Zhou, Linna Shi, Fujin Fang, Changliang Zhu, Guiyun Yan
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10.1371/journal.ppat.1004231

PLOS Pathogens Human IGF1 Regulates Midgut Oxidative Stress and Epithelial Homeostasis to Balance Lifespan and Plasmodium falciparum resistance in Anopheles stephensi
June 26, 2014 Anna Drexler, Jose Pietri, Nazzy Pakpour, Eric Hauck, Bo Wang, Elizabeth Glennon, Martha Georgis, Michael Riehle, Shirley Luckhart
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10.1371/journal.pntd.0003005

PLOS Neglected Tropical Diseases Transcriptome Sequencing and Developmental Regulation of Gene Expression in Anopheles aquasalis
July 17, 2014 André Costa-da-Silva, Osvaldo Marinotti, José Ribeiro, Maria Silva, Adriana Lopes, Michele Barros, Anderson Sá-Nunes, Bianca Kojin, Eneas Carvalho, Lincoln Suesdek, Mário Silva-Neto, Anthony James, Margareth Capurro
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10.1371/journal.ppat.1004182

PLOS Pathogens Wolbachia Can Enhance Plasmodium Infection in Mosquitoes: Implications for Malaria Control?
September 4, 2014 Grant Hughes, Ana Rivero, Jason Rasgon
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10.1371/journal.ppat.1004338

PLOS Pathogens Plasmodium falciparum Infection Induces Expression of a Mosquito Salivary Protein (Agaphelin) That Targets Neutrophil Function and Inhibits Thrombosis without Impairing Hemostasis
September 11, 2014 Michael Waisberg, Alvaro Molina-Cruz, Daniella Mizurini, Nidhi Gera, Beatriz Sousa, Dongying Ma, Ana Leal, Taina Gomes, Michalis Kotsyfakis, Jose Ribeiro, Jan Lukszo, Karine Reiter, Stephen Porcella, Carlo Oliveira, Robson Monteiro, Carolina Barillas-Mury, Susan Pierce, Ivo Francischetti
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10.1371/journal.pmed.1001169

PLOS Neglected Tropical Diseases Benefit of Insecticide-Treated Nets, Curtains and Screening on Vector Borne Diseases, Excluding Malaria: A Systematic Review and Meta-analysis
October 9, 2014 Anne Wilson, Ramesh Dhiman, Uriel Kitron, Thomas Scott, Henk van den Berg, Steve Lindsay
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10.1371/journal.pntd.0003393

PLOS Neglected Tropical Diseases How Effective is Integrated Vector Management Against Malaria and Lymphatic Filariasis Where the Diseases Are Transmitted by the Same Vector?
December 11, 2014 Christopher Stone, Steve Lindsay, Nakul Chitnis
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10.1371/journal.pntd.0003326

PLOS Neglected Tropical Diseases Field Evaluation of Picaridin Repellents Reveals Differences in Repellent Sensitivity between Southeast Asian Vectors of Malaria and Arboviruses
December 18, 2014 Karel Van Roey, Mao Sokny, Leen Denis, Nick Van den Broeck, Somony Heng, Siv Sovannaroth, Vincent Sluydts, Tho Sochantha, Marc Coosemans, Lies Durnez

Targeting the parasite: Coinfections

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10.1371/journal.pcbi.1003018

PLOS Computational Biology Biomarker Discovery by Sparse Canonical Correlation Analysis of Complex Clinical Phenotypes of Tuberculosis and Malaria
April 18, 2013 Juho Rousu, Daniel Agranoff, Olugbemiro Sodeinde, Jonh Shawe-Taylor, Delmiro Fernandez-Reyes
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10.1371/journal.ppat.1003327

PLOS Pathogens Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria Pathogenesis
May 16, 2013 Steve Taylor, Carla Cerami, Rick Fairhurst
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10.1371/journal.pcbi.1003096

PLOS Computational Biology Modelling Co-Infection with Malaria and Lymphatic Filariasis
June 13, 2013 Hannah Slater, Manoj Gambhir, Paul Parham, Edwin Michael
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10.1371/journal.pntd.0002380

PLOS Neglected Tropical Diseases Helminthic Infections Rates and Malaria in HIV-Infected Pregnant Women on Anti-Retroviral Therapy in Rwanda
August 15, 2013 Emil Ivan, Nigel Crowther, Eugene Mutimura, Lawrence Osuwat, Saskia Janssen, Martin Grobusch
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10.1371/journal.pntd.0002420

PLOS Neglected Tropical Diseases Discriminating Malaria from Dengue Fever in Endemic Areas: Clinical and Biological Criteria, Prognostic Score and Utility of the C-Reactive Protein: A Retrospective Matched-Pair Study in French Guiana
September 12, 2013 Loïc Epelboin, Charlotte Boullé, Sihem Ouar-Epelboin, Matthieu Hanf, Philippe Dussart, Félix Djossou, Mathieu Nacher, Bernard Carme
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10.1371/journal.ppat.1004049

PLOS Pathogens Malaria Parasite Infection Compromises Control of Concurrent Systemic Non-typhoidal Salmonella Infection via IL-10-Mediated Alteration of Myeloid Cell Function
May 1, 2014 Kristen Lokken, Jason Mooney, Brian Butler, Mariana Xavier, Jennifer Chau, Nicola Schaltenberg, Ramie Begum, Werner Müller, Shirley Luckhart, Renée M. Tsolis
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10.1371/journal.pntd.0002896

PLOS Neglected Tropical Diseases Community Knowledge and Attitudes and Health Workers’ Practices regarding Non-malaria Febrile Illnesses in Eastern Tanzania
May 22, 2014 Beatrice Chipwaza, Joseph Mugasa, Iddy Mayumana, Mbaraka Amuri, Christina Makungu, Paul Gwakisa
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10.1371/journal.ppat.1004170

PLOS Pathogens A Multifactorial Role for P. falciparum Malaria in Endemic Burkitt’s Lymphoma Pathogenesis
May 29, 2014 Charles Torgbor, Peter Awuah, Kirk Deitsch, Parisa Kalantari, Karen A. Duca, David A. Thorley-Lawson
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10.1371/journal.pntd.0002913

PLOS Neglected Tropical Diseases Infection and Co-infection with Helminths and Plasmodium among School Children in Côte d’Ivoire: Results from a National Cross-Sectional Survey
June 5, 2014 Richard Yapi, Eveline Hürlimann, Clarisse Houngbedji, Prisca Ndri, Kigbafori Silué, Gotianwa Soro, Ferndinand Kouamé, Penelope Vounatsou, Thomas Fürst, Eliézer N'Goran, Jürg Utzinger, Giovanna Raso
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10.1371/journal.ppat.1004263

PLOS Pathogens BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei
July 17, 2014 Rebecca Oppenheim, Darren Creek, James MacRae, Katarzyna MODRZYNSKA, Paco Pino, Julien Limenitakis, Valérie Polonais, Frank Seeber, Michael Barrett, Oliver Billker, Malcolm McConville, Dominique Soldati-Favre
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10.1371/journal.pntd.0003154

PLOS Neglected Tropical Diseases Co-infection of Long-Term Carriers of Plasmodium falciparum with Schistosoma haematobium Enhances Protection from Febrile Malaria: A Prospective Cohort Study in Mali
September 11, 2014 Safiatou Doumbo, Tuan Tran, Jules Sangala, Shanping Li, Didier Doumtabe, Younoussou Kone, Abdrahamane Traoré, Aboudramane Bathily, Nafomon Sogoba, Michel Coulibaly, Chiung‐Yu Huang, Aissata Ongoiba, Kassoum Kayentao, Mouctar Diallo, Zongo Dramane, Thomas Nutman, Peter Crompton, Ogobara Doumbo, Boubacar Traore
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10.1371/journal.pntd.0003248

PLOS Neglected Tropical Diseases Prevalence and Intensity of Soil-Transmitted Helminthiasis, Prevalence of Malaria and Nutritional Status of School Going Children in Honduras
October 16, 2014 Rosa Mejia Torres, Dora Franco Garcia, Gustavo Fontecha Sandoval, Adriana Hernandez Santana, Prabhjot Singh, Sandra Mancero Bucheli, Martha Saboyá, Mirian Paz
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10.1371/journal.pntd.0003234

PLOS Neglected Tropical Diseases Impact of Schistosoma mansoni on Malaria Transmission in Sub-Saharan Africa
October 16, 2014 Martial Ndeffo Mbah, Laura Skrip, Scott Greenhalgh, Peter Hotez, Alison Galvani
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10.1371/journal.pntd.0003236

PLOS Neglected Tropical Diseases Co-infections of Malaria and Geohelminthiasis in Two Rural Communities of Nkassomo and Vian in the Mfou Health District, Cameroon
October 16, 2014 Francis ZEUKENG, Viviane Hélène TCHINDA, Jude BIGOGA, Clovis Hugues SEUMEN, Edward NDZI, Geraldine ABONWEH, Valérie MAKOGE, Amédée MOTSEBO, Roger MOYOU
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10.1371/journal.pntd.0003239

PLOS Neglected Tropical Diseases P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon
October 23, 2014 Belisa Magalhães, André Siqueira, Márcia Alexandre, Marcela Souza, João Gimaque, Michele Bastos, Regina Figueiredo, Gisely Melo, Marcus Lacerda, Maria Paula Mourão
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10.1371/journal.pntd.0003660

PLOS Neglected Tropical Diseases Distribution and Risk Factors for Plasmodium and Helminth Co-infections: A Cross-Sectional Survey among Children in Bagamoyo District, Coastal Region of Tanzania
April 2, 2015 Nahya Salim, Stefanie Knopp, Omar Lweno, Ummi Abdul, Ali Mohamed, Tobias Schindler, Julian Rothen, John Masimba, Denis Kwaba, Alisa Mohammed, Fabrice Althaus, Salim Abdulla, Marcel Tanner, Claudia Daubenberger, Blaise Genton

Testing Implementation and Outcomes Studies in Human Populations: Control/treatment

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10.1371/journal.pmed.1001417

PLOS Medicine Measuring Coverage in MNCH: Accuracy of Measuring Diagnosis and Treatment of Childhood Malaria from Household Surveys in Zambia
May 7, 2013 Thomas Eisele, Kafula Silumbe, Josh Yukich, Busiku Hamainza, Joseph Keating, Adam Bennett, John Miller
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10.1371/journal.ppat.1003375

PLOS Pathogens Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications
May 23, 2013 Jennifer Guler, Daniel Freeman, Vida Ahyong, Rapatbhorn Patrapuvich, John White, Ramesh Gujjar, Margaret Phillips, Joseph DeRisi, Pradipsinh Rathod
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10.1371/journal.pmed.1001467

PLOS Medicine Targeting Asymptomatic Malaria Infections: Active Surveillance in Control and Elimination
June 18, 2013 Hugh Sturrock, Michelle Hsiang, Justin Cohen, Dave Smith, Bryan Greenhouse, Teun Bousema, Roly Gosling
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10.1371/journal.pmed.1001488

PLOS Medicine Factors Affecting the Delivery, Access, and Use of Interventions to Prevent Malaria in Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis
July 23, 2013 Jenny Hill, Jenna Hoyt, Anna Maria van Eijk, Lauren D'Mello-Guyett, Feiko Ter Kuile, Richard Steketee, Helen Smith, Jayne Webster
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10.1371/journal.pmed.1001169

PLOS Medicine Scale-up of Malaria Rapid Diagnostic Tests and Artemisinin-Based Combination Therapy: Challenges and Perspectives in Sub-Saharan Africa
January 21, 2014 Guido Bastiaens, Teun Bousema, Toby Leslie
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10.1371/journal.pmed.1001169

PLOS Medicine The Failure of Screening and Treating as a Malaria Elimination Strategy
January 28, 2014 Lorenz von Seidlein
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10.1371/journal.pmed.1001594

PLOS Medicine Impact of Intermittent Screening and Treatment for Malaria among School Children in Kenya: A Cluster Randomised Trial
January 28, 2014 Katherine Halliday, George Okello, Elizabeth Turner, Kiambo Njagi, Carlos Mcharo, Juddy Kengo, Elizabeth Allen, Margaret Dubeck, Matthew Jukes, Simon Brooker
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10.1371/journal.pmed.1001642

PLOS Medicine Communicating and Monitoring Surveillance and Response Activities for Malaria Elimination: China’s “1-3-7” Strategy
May 13, 2014 Jun Cao, Hugh Sturrock, Chris Cotter, Shuisen Zhou, Huayun Zhou, Yaobao Liu, Linhua Tang, Roly Gosling, Richard Feachem, Qi Gao
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10.1371/journal.pntd.0002978

PLOS Neglected Tropical Diseases Transmission and Control of Plasmodium knowlesi: A Mathematical Modelling Study
July 24, 2014 Natsuko Imai, Michael White, Azra Ghani, Chris Drakeley
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10.1371/journal.pmed.1001685

PLOS Medicine Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites
July 29, 2014 RTS,S Clinical Trials Partnership (Group Name), Mary Hamel
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10.1371/journal.pmed.1001689

PLOS Medicine Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial
August 5, 2014 Victor Bigira, James Kapisi, Tamara Clark, Stephen Kinara, Florence Mwangwa, Mary Muhindo, Beth Osterbauer, Francesca Aweeka, Liusheng Huang, Jane Achan, Diane Havlir, Philip Rosenthal, Moses Kamya, Grant Dorsey
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10.1371/journal.pmed.1001169

PLOS Medicine Ethics, Economics, and the Use of Primaquine to Reduce Falciparum Malaria Transmission in Asymptomatic Populations
August 19, 2014 Yoel Lubell, Lisa White, Sheila Varadan, Tom Drake, Shunmay Yeung, Phaik Yeong Cheah, Richard Maude, Arjen Dondorp, Nicholas Day, Nicholas White, Michael Parker
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10.1371/journal.pmed.1001735

PLOS Medicine Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Infected Women Receiving Cotrimoxazole Prophylaxis: A Multicenter Randomized Placebo-Controlled Trial
September 23, 2014 Raquel González, Meghna Desai, Eusebio Macete, Peter Ouma, Mwaka Kakolwa, Salim Abdulla, John Aponte, Helder Bulo, Abdunoor Kabanywany, Abraham Katana, Sonia Maculuve, Alfredo Mayor, Arsenio Nhacolo, Kephas Otieno, Golbahar Pahlavan, María Rupérez, Esperança Sevene, Laurence Slutsker, Anifa Vala, John Williamsom, Clara Menendez
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Jack Zalium, Flickr

PLOS Medicine Malaria Prevention during Pregnancy—Is There a Next Step Forward?
September 23, 2014 Richard Steketee
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10.1371/journal.pmed.1001733

PLOS Medicine Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Negative Women: A Multicentre Randomized Controlled Trial
September 23, 2014 Raquel González, Ghyslain Mombo-Ngoma, Smaïla Ouédragou, Mwaka Kakolwa, Salim Abdulla, Manfred Accrombessi, John Aponte, Arti Basra, Valérie Briand, Meskure Capan, Michel Cot, Daisy Akerey -Diop, Abdunoor Kabanywany, Christian Kleine, Peter Kremsner, Eusebio Macete, Jean-Rodolphe Mackanga, Achille Massougbodgi, Alfredo Mayor, Arsenio Nhacolo, Golbahar Pahlavan, Michael Ramharter, María Rupérez, Esperança Sevene, Anifa Vala, Rella Zoleko-Manego, Clara Menendez
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10.1371/journal.pmed.1001773

PLOS Medicine Artemisinin-Naphthoquine versus Artemether-Lumefantrine for Uncomplicated Malaria in Papua New Guinean Children: An Open-Label Randomized Trial
December 30, 2014 Moses Laman, Brioni Moore, John Benjamin, Gumul Yadi, Cathy Bona, Jonathan Warrel, Johanna Kattenberg, Tamarah Koleala, Laurens Manning, Bernadine Kasian, Leanne Robinson, Naomi Sambale, Lina Lorry, Stephan Karl, Wendy Davis, Anna Rosanas-Urgell, Ivo Mueller, Peter Siba, Inoni Betuela, tim davis
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10.1371/journal.pntd.0003469

PLOS Neglected Tropical Diseases Characterization of Plasmodium ovale curtisi and P. ovale wallikeri in Western Kenya Utilizing a Novel Species-specific Real-time PCR Assay
January 15, 2015 Robin Miller, Clifford Obuya, Elizabeth Wanja, Bernhards Ogutu, John Waitumbi, Shirley Luckhart, V. Ann Stewart
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10.1371/journal.pcbi.1004057

PLOS Computational Biology The Interaction between Seasonality and Pulsed Interventions against Malaria in Their Effects on the Reproduction Number
January 15, 2015 Jamie Griffin
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10.1371/journal.pmed.1001564

PLOS Medicine The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
December 3, 2013 Ric Price, Jane Achan, Ishag Adams, Emmanuel Arinaitwe, Elizabeth Ashley, Ghulam Awab, Mamadou Ba, Karen Barnes et al
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10.1371/journal.pmed.1001169

PLOS Medicine Artemisinin Combination Therapy: A Good Antimalarial, but Is the Dose Right?
December 3, 2013 Paul Garner

Testing Implementation and Outcomes Studies in Human Populations: Epidemiology

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10.1371/journal.pntd.0002026

PLOS Neglected Tropical Diseases Increasing Incidence of Plasmodium knowlesi Malaria following Control of P. falciparum and P. vivax Malaria in Sabah, Malaysia
January 24, 2013 Timothy William, Hasan Rahman, Jenarun Jelip, Mohammad Ibrahim, Jayaram Menon, Matthew Grigg, Tsin Yeo, Nicholas Anstey, Bridget Barber
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10.1371/journal.pmed.1001398

PLOS Medicine Malaria Burden and Artemisinin Resistance in the Mobile and Migrant Population on the Thai–Myanmar Border, 1999–2011: An Observational Study
March 5, 2013 Verena Carrara, Khin Lwin, Aung Phyo, Elizabeth Ashley, Jacher Wiladphaingern, Kanlaya Sriprawat, Marcus Rijken, Machteld Boel, Rose McGready, Stephane Proux, Cindy Chu, Pratap Singhasivanon, Nicholas White, Nosten Francois
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10.1371/journal.pntd.0002180

PLOS Neglected Tropical Diseases False Positivity of Non-Targeted Infections in Malaria Rapid Diagnostic Tests: The Case of Human African Trypanosomiasis
April 25, 2013 Philippe Gillet, Dieudonné Mumba Ngoyi, Albert Lukuka, Viktor Kande, Benjamin Atua, Johan van Griensven, Jean-Jacques Muyembe, Jan Jacobs, Veerle Lejon
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10.1371/journal.pntd.0002522

PLOS Neglected Tropical Diseases Microsatellite DNA Analysis Revealed a Drastic Genetic Change of Plasmodium vivax Population in the Republic of Korea During 2002 and 2003
October 31, 2013 Moritoshi Iwagami, Seung-Young Hwang, So-Hee Kim, So-Jung Park, Ga-Young Lee, Emilie Matsumoto-Takahashi, Weon-Gyu Kho, Shigeyuki Kano
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10.1371/journal.pcbi.1003312

PLOS Computational Biology Improving the Modeling of Disease Data from the Government Surveillance System: A Case Study on Malaria in the Brazilian Amazon
November 7, 2013 Denis Valle, James Clark
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10.1371/journal.pntd.0002622

PLOS Neglected Tropical Diseases Congenital Malaria in China
March 13, 2014 Zhiyong Tao, Qiang Fang, Xue Liu, Richard Culleton, Li Tao, Hui Xia, Qi Gao
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10.1371/journal.pntd.0002780

PLOS Neglected Tropical Diseases Defining the Geographical Range of the Plasmodium knowlesi Reservoir
March 27, 2014 Catherine Moyes, Andrew Henry, Nick Golding, Zhi Huang, Balbir Singh, J. Baird, Paul Newton, Michael Huffman, Kirsten Duda, Chris Drakeley, Nicholas Anstey, Iqbal Elyazar, Quijun Chen, Zinta Zommers, Samir Bhatt, Peter Gething, Simon Hay
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10.1371/journal.pntd.0003109

PLOS Neglected Tropical Diseases Epidemiology of Disappearing Plasmodium vivax Malaria: A Case Study in Rural Amazonia
August 28, 2014 Susana Barbosa, Amanda Gozze, Nathália Lima, Camilla Batista, Melissa Bastos, Vanessa Nicolete, Pablo Fontura, Raquel Gonçalves, Susana Viana, Maria Menezes, Kézia Scopel, Carlos Cavasini, Rosely Malafronte, Mônica Silva-Nunes, Joseph Vinetz, Marcia Castro, Marcelo Ferreira