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PLOS Medicine Top 10%

PLOS Medicine is home to the latest medical research of global societal importance -- available immediately, to every reader. Each year, we celebrate the impact our authors have had in their research fields and share out the body of work that has earned the top 10% of citations. We hope you enjoy exploring this Collection.

2014
2015
2016
  • The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling

    Background: The existing estimate of the global burden of latent TB infection (LTBI) as “one-third” of the world population is nearly 20 y…

  • Image credit
    fdecomite
    Epidemiology and Reporting Characteristics of Systematic Reviews of Biomedical Research: A Cross-Sectional Study
  • Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

    Background: Ebola virus disease (EVD) is a highly lethal condition for which no specific treatment has proven efficacy. In September 2014,…

  • Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982–2012: A Systematic Analysis

    Background: The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden.…

  • Prices, Costs, and Affordability of New Medicines for Hepatitis C in 30 Countries: An Economic Analysis

    Introduction: New hepatitis C virus (HCV) medicines have markedly improved treatment efficacy and regimen tolerability. However, their high…

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    10.1371/journal.pmed.1002150
    Burden of Six Healthcare-Associated Infections on European Population Health: Estimating Incidence-Based Disability-Adjusted Life Years through a Population Prevalence-Based Modelling Study
  • Initiating Antiretroviral Therapy for HIV at a Patient’s First Clinic Visit: The RapIT Randomized Controlled Trial

    Background: High rates of patient attrition from care between HIV testing and antiretroviral therapy (ART) initiation have been documented…

  • Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

    Background: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly…

  • Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies

    Background: Plant-based diets have been recommended to reduce the risk of type 2 diabetes (T2D). However, not all plant foods are…

  • Patient-Reported Barriers to Adherence to Antiretroviral Therapy: A Systematic Review and Meta-Analysis

    Background: Maintaining high levels of adherence to antiretroviral therapy (ART) is a challenge across settings and populations.…

  • Early Childhood Developmental Status in Low- and Middle-Income Countries: National, Regional, and Global Prevalence Estimates Using Predictive Modeling

    Background: The development of cognitive and socioemotional skills early in life influences later health and well-being. Existing estimates…

  • Image credit
    liz west, Flickr
    Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials
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    Wikimedia
    Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis
  • Integrated Delivery of Antiretroviral Treatment and Pre-exposure Prophylaxis to HIV-1–Serodiscordant Couples: A Prospective Implementation Study in Kenya and Uganda

    Background: Antiretroviral-based interventions for HIV-1 prevention, including antiretroviral therapy (ART) to reduce the infectiousness of…

2017
  • Zika Virus Infection as a Cause of Congenital Brain Abnormalities and Guillain–Barré Syndrome: Systematic Review

    Background: The World Health Organization (WHO) stated in March 2016 that there was scientific consensus that the mosquito-borne Zika virus…

  • Changes in prices, sales, consumer spending, and beverage consumption one year after a tax on sugar-sweetened beverages in Berkeley, California, US: A before-and-after study

    Background: Taxes on sugar-sweetened beverages (SSBs) meant to improve health and raise revenue are being adopted, yet evaluation is…

  • The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight

    Background: Perinatal mortality and morbidity continue to be major global health challenges strongly associated with prematurity and…

  • Image credit
    geralt, Pixabay
    Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
  • Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study

    Background: Prescription opioid use is highly associated with risk of opioid-related death, with 1 of every 550 chronic opioid users dying…

  • Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach

    Background: The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain. Methods…

  • Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

    Background: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes.…

  • Self-monitoring of blood pressure in hypertension: A systematic review and individual patient data meta-analysis

    Background: Self-monitoring of blood pressure (BP) appears to reduce BP in hypertension but important questions remain regarding effective…

  • HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study

    Background: It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or…

  • Image credit
    NIH, Wikipedia
    APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases
  • Same-day HIV testing with initiation of antiretroviral therapy versus standard care for persons living with HIV: A randomized unblinded trial

    Background: Attrition during the period from HIV testing to antiretroviral therapy (ART) initiation is high worldwide. We assessed whether…

  • Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis

    Background: Inhibition of programmed death-ligand 1 (PD-L1) with atezolizumab can induce durable clinical benefit (DCB) in patients with…

  • Image credit
    hey__paul, Flickr
    Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study
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    10.1371/journal.pmed.1002277
    Risk prediction models for selection of lung cancer screening candidates: A retrospective validation study
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    10.1371/journal.pmed.1002224
    Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens
  • A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial

    Background: The Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets require that, by 2020, 90% of those living with HIV…

  • Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: A prospective, observational, multicenter cohort study

    Background: Graft-derived cell-free DNA (GcfDNA), which is released into the blood stream by necrotic and apoptotic cells, is a promising…

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    10.1371/journal.pmed.1002909.g004
    Housing Improvements and Malaria Risk in Sub-Saharan Africa: A Multi-Country Analysis of Survey Data
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