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Biology & Life Sciences

Advances in HIV Mucosal Immunology: Challenges and Opportunities

Partnered Collections, Special Issues

Without reliable methods to evaluate how the mucosal immune system responds to an experimental HIV vaccine, important information about how well that vaccine worked is missed. The HIV Mucosal Immunology Group (MIG) was established to address the challenge of assessing the impact of potential HIV vaccines on the mucosal immune system. The MIG comprises of expert scientists who are coordinating their efforts to improve mucosal sampling, specimen storage and assay technologies. This collection reports the results of those efforts, providing important, practical details on studying immune responses in the genital and rectal mucosa.

Image Credit: Artistic rendition of immune cells and potential HIV targets in the rectal mucosal. Yang, Ochoa, Preza & Anton, 2014

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An artistic rendition of Lymphocytes (orange), macrophages (purple), dendritic cells (green) and Langerhans-like cells (red) overlaid onto a confocal microscopic image from a sectioned rectal mucosal biopsy, using DAPI-staining of cell nuclei.

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