Medicine & Health

Mycetoma

Published June 8, 2016 Curated Collections

Mycetoma is a serious and debilitating condition that meets all of the criteria we ordinarily attribute to a neglected tropical disease (NTD). Classically, it is a destructive fungal or bacterial infection of the foot (although other body parts can be affected) that results in disfigurement and social stigma. It overwhelmingly occurs in impoverished areas of a “mycetoma belt” that extends across the globe, roughly between the Equator and the Tropic of Cancer, with most of the cases reported from India, Mexico, Sudan, several countries in Africa’s Sahel (including Chad, Mali, and Mauritania), and Somalia and Yemen.

Image Credit: Uncalno Tekno

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Editorial

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Uncalno Tekno

PLOS Neglected Tropical Diseases Mycetoma: A Long Journey from Neglect
January 21, 2016 Eduard Zijlstra, Wendy van de Sande, Ahmed Fahal

Collection Blog

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Fig. 1. Prevalence and Reported Cases of Mycetoma. A: Average prevalence of mycetoma cases as calculated by the number of cases reported in a year in a certain country divided trough the total population of that country of that same year as reported by www.indexmundi.com/facts/indicators/SP.POP.TOTL/compare. B: The average number of mycetoma cases reported per year per country. From van de Sande WWJ (2013) Global Burden of Human Mycetoma: A Systematic Review and Meta-analysis. PLoS Negl Trop Dis 7(11): e2550. doi:10.1371/journal.pntd.0002550 http://journals.plos.org/plosntds/article?id=info:doi/10.1371/journal.pntd.0002550

Speaking of Medicine Mycetoma: The PLOS NTDs Collection
January 21, 2016 Peter Hotez and Serap Askoy

Public Health

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10.1371/journal.pntd.0002400

PLOS Neglected Tropical Diseases Mycetoma Herbal Treatment: The Mycetoma Research Centre, Sudan Experience
August 22, 2013 Eshraga A. Ezaldeen, Ahmed Hassan Fahal, Anjom Osman
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10.1371/journal.pntd.0002667

PLOS Neglected Tropical Diseases The Mycetoma Knowledge Gap: Identification of Research Priorities
March 27, 2014 Wendy W. J. van de Sande, El Sheikh Maghoub, Ahmed H. Fahal, Michael Goodfellow, Oliverio Welsh, Ed Zijlstra
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10.1371/journal.pntd.0003679

PLOS Neglected Tropical Diseases Mycetoma in the Sudan: An Update from the Mycetoma Research Centre, University of Khartoum, Sudan
March 27, 2015 Ahmed Fahal, EL Sheikh Mahgoub, Ahmed M. EL Hassan, Manar Elsheikh Abdel-Rahman
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10.1371/journal.pntd.0003250

PLOS Neglected Tropical Diseases Mapping the Potential Risk of Mycetoma Infection in Sudan and South Sudan Using Ecological Niche Modeling
October 16, 2014 Abdallah M. Samy, Wendy W. J. van de Sande, Ahmed Hassan Fahal, A. Townsend Peterson
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10.1371/journal.pntd.0002550

PLOS Neglected Tropical Diseases Global Burden of Human Mycetoma: A Systematic Review and Meta-analysis
November 7, 2013 Wendy W. J. van de Sande
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10.1371/journal.pntd.0003271

PLOS Neglected Tropical Diseases A New Model for Management of Mycetoma in the Sudan
October 30, 2014 Ahmed Fahal, El Sheikh Mahgoub, Ahmed Mohamed EL Hassan, Manar Elsheikh Abdel-Rahman, Yassir Alshambaty, Ahmed Hashim, Ali Hago, Eduard E. Zijlstra

Clinical

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PLOS Neglected Tropical Diseases Last Generation Triazoles for Imported Eumycetoma in Eleven Consecutive Adults
October 9, 2014 Yoann Crabol, Sylvain Poiree, Marie-Elisabeth Bougnoux, Christophe Maunoury, Stéphane Barete, Valérie Zeller, Cédric Arvieux, Samuel Pineau, Karima Amazzough, Marc Lecuit, Fanny Lanternier, Olivier Lortholary, the French Mycosis Study Group
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Uncalno Tekno

PLOS Neglected Tropical Diseases The Combination of Amoxicillin-Clavulanic Acid and Ketoconazole in the Treatment of Madurella mycetomatis Eumycetoma and Staphylococcus aureus Co-infection
June 19, 2014 Najwa A. Mhmoud, Ahmed Hassan Fahal, El Sheikh Mahgoub, Wendy W. J. van de Sande
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10.1371/journal.pntd.0003218

PLOS Neglected Tropical Diseases Mycetoma Medical Therapy
October 16, 2014 Oliverio Welsh, Hail Mater Al-Abdely, Mario Cesar Salinas-Carmona, Ahmed Hassan Fahal
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10.1371/journal.pntd.0003729

PLOS Neglected Tropical Diseases Case Report: Actinomycetoma Caused by Nocardia aobensis from Lao PDR with Favourable Outcome after Short-Term Antibiotic Treatment
April 16, 2015 Inthanomchanh Vongphoumy, David A. B. Dance, Sabine Dittrich, Julie Logan, Viengmon Davong, Sayaphet Rattanavong, Joerg Blessmann
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10.1371/journal.pntd.0002241

PLOS Neglected Tropical Diseases Association of Eumycetoma and Schistosomiasis
May 23, 2013 Jaap J. van Hellemond, Alieke G. Vonk, Corné de Vogel, Rob Koelewijn, Norbert Vaessen, Ahmed H. Fahal, Alex van Belkum, Wendy W. J. van de Sande
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10.1371/journal.pntd.0002918

PLOS Neglected Tropical Diseases Merits and Pitfalls of Currently Used Diagnostic Tools in Mycetoma
July 3, 2014 Wendy W. J. van de Sande, Ahmed H. Fahal, Michael Goodfellow, El Sheikh Mahgoub, Oliverio Welsh, Ed E. Zijlstra
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10.1371/journal.pntd.0002081

PLOS Neglected Tropical Diseases Peripheral Blood Mononuclear Cells of Mycetoma Patients React Differently to Madurella mycetomatis Antigens than Healthy Endemic Controls
April 25, 2013 Ehab A. M. Elagab, Maowia M. Mukhtar, Ahmed H. Fahal, Wendy W. J. van de Sande
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10.1371/journal.pntd.0003368

PLOS Neglected Tropical Diseases Rapid Identification of Black Grain Eumycetoma Causative Agents Using Rolling Circle Amplification
December 4, 2014 Sarah A. Ahmed, Bert H. G. Gerrits van den Ende, Ahmed H. Fahal, Wendy W. J. van de Sande, G. S. de Hoog
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10.1371/journal.pntd.0003587

PLOS Neglected Tropical Diseases Head and Neck Mycetoma: The Mycetoma Research Centre Experience
March 13, 2015 Ahmed Fahal, EL Sheikh Mahgoub, Ahmed Mohamed EL Hassan, Angom Osman Jacoub, Doaa Hassan
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10.1371/journal.pntd.0000772

PLOS Neglected Tropical Diseases A Woman with Chronic Subcutaneous Swelling of the Right Foot Associated with Sinus Tracts Discharging Yellow Grains
September 28, 2010 Ildefonso Tellez, Carlos Franco-Paredes
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10.1371/journal.pntd.0003102

PLOS Neglected Tropical Diseases Mycetoma: Experience of 482 Cases in a Single Center in Mexico
August 21, 2014 Alexandro Bonifaz, Andrés Tirado-Sánchez, Luz Calderón, Amado Saúl, Javier Araiza, Marco Hernández, Gloria M. González, Rosa María Ponce

Basic Science

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10.1371/journal.pntd.0004061

PLOS Neglected Tropical Diseases A Polymorphism in the Chitotriosidase Gene Associated with Risk of Mycetoma Due to Madurella mycetomatis Mycetoma–A Retrospective Study
September 2, 2015 Patricia E. B. Verwer, Charlotte C. Notenboom, Kimberly Eadie, Ahmed H. Fahal, Henri A. Verbrugh, Wendy W. J. van de Sande
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10.1371/journal.pntd.0002942

PLOS Neglected Tropical Diseases Madurella mycetomatis Is Highly Susceptible to Ravuconazole
June 19, 2014 Sarah Abdalla Ahmed, Wendy Kloezen, Frederick Duncanson, Ed E. Zijlstra, G. Sybren de Hoog, Ahmed H. Fahal, Wendy W. J. van de Sande
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10.1371/journal.pntd.0002229

PLOS Neglected Tropical Diseases Phylogenetic Findings Suggest Possible New Habitat and Routes of Infection of Human Eumyctoma
May 16, 2013 G. Sybren de Hoog, Sarah A. Ahmed, Mohammad J. Najafzadeh, Deanna A. Sutton, Maryam Saradeghi Keisari, Ahmed H. Fahal, Ursala Eberhardt, Gerard J. Verkleij, Lian Xin, Benjamin Stielow, Wendy W. J. van de Sande
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10.1371/journal.pntd.0003926

PLOS Neglected Tropical Diseases A Madurella mycetomatis Grain Model in Galleria mellonella Larvae
July 14, 2015 Wendy Kloezen, Marilyn van Helvert-van Poppel, Ahmed H. Fahal, Wendy W. J. van de Sande
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10.1371/journal.pntd.0003488

PLOS Neglected Tropical Diseases The In Vitro Antifungal Activity of Sudanese Medicinal Plants against Madurella mycetomatis, the Eumycetoma Major Causative Agent
March 13, 2015 Hassabelrasoul Elfadil, Wendy Kloezen, Elhadi M. Ahmed, Wendy van de Sande, Ahmed Fahal
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10.1371/journal.pone.0057774

PLOS ONE A Histopathological Exploration of the Madurella mycetomatis Grain
March 6, 2013 Anahid Izzat Ibrahim, Ahmed Mohammed El Hassan, Wendy W. van de Sande, Ahmed Fahal
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10.1371/journal.pntd.0002754

PLOS Neglected Tropical Diseases Active Matrix Metalloprotease-9 Is Associated with the Collagen Capsule Surrounding the Madurella mycetomatis Grain in Mycetoma
March 27, 2014 Kirsten Geneugelijk, Wendy Kloezen, Ahmed H. Fahal, Wendy W. J. van de Sande
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10.1371/journal.pone.0038654

PLOS ONE Phylogenetic Analysis of the Complete Mitochondrial Genome of Madurella mycetomatis Confirms Its Taxonomic Position within the Order Sordariales
June 6, 2012 Wendy W. J. van de Sande
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10.1371/journal.pntd.0002573

PLOS Neglected Tropical Diseases Molecular Identification of Nocardia Isolates from Clinical Samples and an Overview of Human Nocardiosis in Brazil
December 5, 2013 Paulo Victor Pereira Baio, Juliana Nunes Ramos, Louisy Sanches dos Santos, Morgana Fonseca Soriano, Elisa Martins Ladeira, Mônica Cristina Souza, Thereza Cristina Ferreira Camello, Marcio Garcia Ribeiro, Raphael Hirata Junior, Verônica Viana Vieira, Ana Luíza Mattos-Guaraldi
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10.1371/journal.pone.0065425

PLOS ONE Complete Genome Sequence Analysis of Nocardia brasiliensis HUJEG-1 Reveals a Saprobic Lifestyle and the Genes Needed for Human Pathogenesis
June 3, 2013 Lucio Vera-Cabrera, Rocio Ortiz-Lopez, Ramiro Elizondo-Gonzalez, Jorge Ocampo-Candiani
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10.1371/journal.pntd.0000289

PLOS Neglected Tropical Diseases Therapeutic Effect of a Novel Oxazolidinone, DA-7867, in BALB/c Mice Infected with Nocardia brasiliensis
September 10, 2008 Lucio Vera-Cabrera, Alejandra Daw-Garza, Salvador Said-Fernández, Hector Gerardo Lozano-Garza, Noemi Waksman de Torres, Norma Cavazos Rocha, Jorge Ocampo-Candiani, Sung-Hak Choi, Oliverio Welsh
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10.1371/journal.pntd.0004022

PLOS Neglected Tropical Diseases In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis
October 16, 2015 Norma Alejandra González-Martínez, Hector Gerardo Lozano-Garza, Jorge Castro-Garza, Alexandra De Osio-Cortez, Javier Vargas-Villarreal, Norma Cavazos-Rocha, Jorge Ocampo-Candiani, Vadim Makarov, Stewart T. Cole, Lucio Vera-Cabrera

Speaking of Medicine Blog

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