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Medicine & Health

Advances in Clinical Trial Design for Development of New Treatments for Tuberculosis

Partnered Collections, Special Issues

With recent opportunities to test combinations of new and repurposed drugs for the treatment of TB, new questions arise for optimal clinical trial design. To address these, in March 2018 WHO organized a consultation on “Advances in Clinical Trial Design for New TB Treatments” to identify and outline the optimal characteristics of clinical trial designs to inform policy guidance for new TB regimens. This PLOS Medicine Special Collection assembles a series of articles on current reflections and describes essential new steps in clinical research that will pave the way for the development of tomorrow’s optimal treatment for all forms of TB.

Image Credit: U.S. Centers for Disease Control and Prevention - Medical Illustrator_Public_Domain

Introduction
Definition of new regimens: early clinical development
New trial designs and how they may facilitate regimen development
Considering subjects: trial adherence and special populations
From trials to guidance: bringing evidence to best programme and practice
Conclusion
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PLOS Special Collection Partner

French National Research Institute for Sustainable Development | World Health Organization

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