Biology & Life Sciences

RosettaCon 2014

Published February 8, 2017 Partnered Collections

The Rosetta macromolecular modeling software is a versatile, rapidly developing set of tools that are now being routinely utilized to address state-of-the-art research challenges in academia and industrial research settings. The annual Rosetta Conference (RosettaCon) provides an opportunity for the Rosetta Community to present updates to the Rosetta source code. This Collection describes the results presented at the 2014 conference by participating RosettaCommons labs and demonstrates exciting advances that increase the usability of Rosetta, improve current methods, and introduce completely new protocols.

Image Credit: pone.0023947

Jump to section

Overview
Research

Overview

Image credit
pone.0023947

PLOS ONE Introduction to the Rosetta Special Collection
December 29, 2015 Sagar Khare, Timothy Whitehead

Research

Image credit
10.1371/journal.pcbi.1004661

PLOS Computational Biology Combining Evolutionary Information and an Iterative Sampling Strategy for Accurate Protein Structure Prediction
December 29, 2015 Tatjana Braun, Julia Koehler Leman, Oliver Lange
Image credit
10.1371/journal.pcbi.1004335

PLOS Computational Biology Coupling Protein Side-Chain and Backbone Flexibility Improves the Re-design of Protein-Ligand Specificity
September 23, 2015 Noah Ollikainen, René M. de Jong, Tanja Kortemme
Image credit
10.1371/journal.pone.0140359

PLOS ONE Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactions
October 19, 2015 Andrea Bazzoli, Simon P. Kelow, John Karanicolas
Image credit
10.1371/journal.pone.0138220

PLOS ONE A Framework to Simplify Combined Sampling Strategies in Rosetta
September 17, 2015 Justin R. Porter, Brian D. Weitzner, Oliver F. Lange
Image credit
10.1371/journal.pone.0130433

PLOS ONE A Web Resource for Standardized Benchmark Datasets, Metrics, and Rosetta Protocols for Macromolecular Modeling and Design
September 2, 2015 Shane Ó Conchúir, Kyle A. Barlow, Roland A. Pache, Noah Ollikainen, Kale Kundert, Matthew J. O'Meara, Colin A. Smith, Tanja Kortemme
Image credit
10.1371/journal.pcbi.1004398

PLOS Computational Biology An Integrated Framework Advancing Membrane Protein Modeling and Design
August 31, 2015 Rebecca F. Alford, Julia Koehler Leman, Brian D. Weitzner, Amanda M. Duran, Drew C. Tilley, Assaf Elazar, Jeffrey J. Gray
Image credit
10.1371/journal.pone.0132508

PLOS ONE Fully Flexible Docking of Medium Sized Ligand Libraries with RosettaLigand
July 23, 2015 Samuel DeLuca, Karen Khar, Jens Meiler
Image credit
10.1371/journal.pone.0131612

PLOS ONE DARC 2.0: Improved Docking and Virtual Screening at Protein Interaction Sites
July 15, 2015 Ragul Gowthaman, Sergey Lyskov, John Karanicolas
Image credit
10.1371/journal.pcbi.1004300

PLOS Computational Biology Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences
July 5, 2015 Alexander M. Sevy, Tim M. Jacobs, James E. Crowe, Jens Meiler
Image credit
10.1371/journal.pone.0125941

PLOS ONE Application of Enhanced Sampling Monte Carlo Methods for High-Resolution Protein-Protein Docking in Rosetta
June 7, 2015 Zhe Zhang, Christina E. M. Schindler, Oliver F. Lange, Martin Zacharias
Image credit
10.1371/journal.pone.0127053

PLOS ONE Capturing Conformational States in Proteins Using Sparse Paramagnetic NMR Data
May 17, 2015 Kala Bharath Pilla, Julia Koehler Leman, Gottfried Otting, Thomas Huber