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Biology & Life Sciences

’Omics of Cellular Signaling Pathways

Curated Collections

The Signaling Pathways Project is a multi-omics knowledgebase based upon public, manually curated transcriptomic and cistromic (ChIP-Seq) datasets involving genetic and small molecule manipulations of cellular receptors, enzymes, transcription factors and co-nodes, as well as model and clinical datasets. The goal is to create a resource where scientists can routinely generate research hypotheses or validate bench relevant to cellular signaling pathways. In this collaboration, SPP biocurators identify articles from PLOS titles that contain publically archived transcriptomic and ChIP-Seq datasets, which are in turn committed to the SPP biocuration pipeline. PLOS articles are listed alongside the SPP version of the dataset, giving readers one-click access to a universe of information through a single Collection. Note: dates on SPP datasets below indicate when they were added to the Collection not Knowledgebase.

Image Credit: Guillaume Paumier

Blog post
Receptors: Transcriptomic
Receptors: Cistromic
Enzymes: Transcriptomic
Enzymes: Cistromic
Transcription factors: Transcriptomic
Transcription factors: Cistromic
Co-nodes: Transcriptomic
Clinical: Transcriptomic
Models: Transcriptomic
PLOS and the Signaling Pathways Project

PLOS has a long-standing commitment to open data access and has partnered with the Signaling Pathways Project to launch a new PLOS Collection. In this collaboration, SPP biocurators identify articles from PLOS titles that contain publically archived transcriptomic and ChIP-Seq datasets, which are in turn committed to the SPP biocuration pipeline. The Collection lists the articles alongside  the SPP version of the dataset, giving readers one-click access to a universe of information through a single Collection dataset.

Funding Statement

SPP is supported under the NIDDK NIDDK Network Coordinating Unit U24 DK097771 and by a grant from the American Thyroid Association

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