Medicine & Health

Early Diagnosis and Treatment of Alzheimer’s Disease

Published June 23, 2020 Calls for Papers Collections

PLOS ONE is excited to publish a Collection on the early diagnosis and treatment of Alzheimer's disease. As the aging population continues to grow, the prevalence of Alzheimer’s disease is expected to rise. The disease incurs enormous economic and social costs and represents a major public health burden. This Collection includes work that provides insights into potential avenues for the treatment of the disease. This is complemented by a wealth of studies which report on potential markers of Alzheimer's, including how adoption of machine learning techniques can assist in its detection. Through a combination of advances in the treatment and diagnosis of Alzheimer's disease this Collection takes us closer to reducing the global burden of the disorder.

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Guest Editors
PLOS ONE Collection

Guest Editors

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Michael Weiner, CC0

Michael Weiner Dr. Michael Weiner
May 15, 2019 Guest Editor, PLOS ONE
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Roberta Brinton, CC0

Roberta Brinton Dr. Roberta Brinton
May 15, 2019 Guest Editor, PLOS ONE
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Jussi Tohka, CC0

Jussi Tohka Dr. Jussi Tohka
May 15, 2019 Guest Editor, PLOS ONE
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Yona Levites, CC0

Yona Levites Dr. Yona Levites
May 15, 2019 Guest Editor, PLOS ONE

PLOS ONE Collection

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10.1371/journal.pone.0234748

PLOS ONE Identification of functionally connected multi-omic biomarkers for Alzheimer’s disease using modularity-constrained Lasso
June 17, 2020 Linhui Xie, Pradeep Varathan, Kwangsik Nho, Andrew Saykin, Paul Salama, Jingwen Yan
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10.1371/journal.pone.0233886

PLOS ONE The impact of atlas-based MR attenuation correction on the diagnosis of FDG-PET/MR for Alzheimer’s diseases— A simulation study combining multi-center data and ADNI-data
June 3, 2020 Tetsuro Sekine, Alfred Buck, Gaspar Delso, Bradley Kemp, Edwin E. G. W. ter Voert, Martin Huellner, Patrick Veit-Haibach, Sandeep Kaushik, Florian Wiesinger, Geoffrey Warnock, for the Alzheimer’s Disease Neuroimaging Initiative
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10.1371/journal.pone.0233289

PLOS ONE An investigation of the correlation between the S-glutathionylated GAPDH levels in blood and Alzheimer’s disease progression
May 29, 2020 Chen Wei Tsai, Chia Fan Tsai, Kuan Hung Lin, Wei Jung Chen, Muh Shi Lin, Cho Chen Hsieh, Chai Ching Lin
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10.1371/journal.pone.0221669

PLOS ONE Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer’s disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca²⁺ dysregulation: Therapeutic implications
May 21, 2020 Viviana Soto-Mercado, Miguel Mendivil-Perez, Carlos Velez-Pardo, Francisco Lopera, Marlene Jimenez-Del-Rio
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10.1371/journal.pone.0232103

PLOS ONE Improving predictive models for Alzheimer’s disease using GWAS data by incorporating misclassified samples modeling
April 23, 2020 Brissa-Lizbeth Romero-Rosales, Jose-Gerardo Tamez-Pena, Humberto Nicolini, Maria-Guadalupe Moreno-Treviño, Victor Trevino
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10.1371/journal.pone.0231765

PLOS ONE Urine dicarboxylic acids change in pre-symptomatic Alzheimer’s disease and reflect loss of energy capacity and hippocampal volume
April 16, 2020 K. J. Castor, S. Shenoi, S. P. Edminster, T. Tran, K. S. King, H. Chui, J. M. Pogoda, A. N. Fonteh, M. G. Harrington
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PLOS ONE Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons
March 24, 2020 Jessica L. Binder, Praveen Chander, Vojo Deretic, Jason P. Weick, Kiran Bhaskar
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10.1371/journal.pone.0229819

PLOS ONE Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis
March 23, 2020 Mengshi Zhou, Rong Xu, David C. Kaelber, Mark E. Gurney
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10.1371/journal.pone.0229460

PLOS ONE A machine learning-based linguistic battery for diagnosing mild cognitive impairment due to Alzheimer’s disease
March 5, 2020 Sylvester Olubolu Orimaye, Karl Goodkin, Ossama Abid Riaz, Jean-Maurice Miranda Salcedo, Thabit Al-Khateeb, Adeola Olubukola Awujoola, Patrick Olumuyiwa Sodeke
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Laurynas Mereckas

PLOS ONE Association of combination statin and antihypertensive therapy with reduced Alzheimer’s disease and related dementia risk
March 4, 2020 Douglas Barthold, Geoffrey Joyce, Roberta Diaz Brinton, Whitney Wharton, Patrick Gavin Kehoe, Julie Zissimopoulos
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10.1371/journal.pone.0228064

PLOS ONE Using practice effects for targeted trials or sub-group analysis in Alzheimer’s disease: How practice effects predict change over time
February 21, 2020 Guoqiao Wang, Richard E. Kennedy, Terry E. Goldberg, Mackenzie E. Fowler, Gary R. Cutter, Lon S. Schneider
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PLOS ONE Cognitively unimpaired adults’ reactions to disclosure of amyloid PET scan results
February 13, 2020 Emily A. Largent, Kristin Harkins, Christopher H. van Dyck, Sara Hachey, Pamela Sankar, Jason Karlawish
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10.1371/journal.pone.0228720

PLOS ONE Identification of amyloid plaques in the brain using an x-ray photon-counting strip detector
February 11, 2020 Bahaa Ghammraoui, Aldo Badano
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10.1371/journal.pone.0227835

PLOS ONE An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury
January 24, 2020 Marie Altendahl, Pauline Maillard, Danielle Harvey, Devyn Cotter, Samantha Walters, Amy Wolf, Baljeet Singh, Visesha Kakarla, Ida Azizkhanian, Sunil A. Sheth, Guanxi Xiao, Emily Fox, Michelle You, Mei Leng, David Elashoff, Joel H. Kramer, Charlie Decarli, Fanny Elahi, Jason D. Hinman
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PLOS ONE Redefining transcriptional regulation of the APOE gene and its association with Alzheimer’s disease
January 24, 2020 Eun-Gyung Lee, Jessica Tulloch, Sunny Chen, Lesley Leong, Aleen D. Saxton, Brian Kraemer, Martin Darvas, C. Dirk Keene, Andrew Shutes-David, Kaitlin Todd, Steve Millard, Chang-En Yu
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CC0

PLOS ONE Clinicians’ communication with patients receiving a MCI diagnosis: The ABIDE project
January 21, 2020 Leonie N. C. Visser, Ingrid S. van Maurik, Femke H. Bouwman, Salka Staekenborg, Ralph Vreeswijk, Liesbeth Hempenius, Marlijn H. de Beer, Gerwin Roks, Leo Boelaarts, Mariska Kleijer, Wiesje M. van der Flier, Ellen M. A. Smets
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Taylor Maley

PLOS ONE Astrocyte senescence promotes glutamate toxicity in cortical neurons
January 16, 2020 Chandani Limbad, Tal Ronnen Oron, Fatouma Alimirah, Albert R. Davalos, Tara E. Tracy, Li Gan, Judith Campisi, Pierre-Yves Desprez
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Matthias Zomer

PLOS ONE Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy
January 15, 2020 Hanneke F. M. Rhodius-Meester, Ingrid S. van Maurik, Juha Koikkalainen, Antti Tolonen, Kristian S. Frederiksen, Steen G. Hasselbalch, Hilkka Soininen, Sanna-Kaisa Herukka, Anne M. Remes, Charlotte E. Teunissen, Frederik Barkhof, Yolande A. L. Pijnenburg, Philip Scheltens, Jyrki Lötjönen, Wiesje M. van der Flier
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10.1371/journal.pone.0227879

PLOS ONE Long-term effects of intracranial islet grafting on cognitive functioning in a rat metabolic model of sporadic Alzheimer’s disease-like dementia
January 13, 2020 Konstantin Bloch, Shay Henry Hornfeld, Shira Dar, Alexey Vanichkin, Irit Gil-Ad, Pnina Vardi, Abraham Weizman
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PLOS ONE Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
January 10, 2020 Da Eun Kwak, Taeho Ko, Han Seok Koh, Yong Woo Ji, Jisu Shin, Kyeonghwan Kim, Hye Yun Kim, Hyung-Keun Lee, YoungSoo Kim
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10.1371/journal.pone.0225392

PLOS ONE Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice
January 9, 2020 Yuan Shang, Aarti Mishra, Tian Wang, Yiwei Wang, Maunil Desai, Shuhua Chen, Zisu Mao, Loi Do, Adam S. Bernstein, Theodore P. Trouard, Roberta D. Brinton
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PLOS ONE Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer’s disease
December 30, 2019 Bradford M. Elmer, Kurt A. Swanson, Dinesh S. Bangari, Peter A. Piepenhagen, Errin Roberts, Tatyana Taksir, Lei Guo, Maria-Carmen Obinu, Pascal Barneoud, Susan Ryan, Bailin Zhang, Laurent Pradier, Zhi-Yong Yang, Gary J. Nabel
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PLOS ONE The use of back propagation neural networks and ¹⁸F-Florbetapir PET for early detection of Alzheimer’s disease using Alzheimer’s Disease Neuroimaging Initiative database
December 26, 2019 Ilker Ozsahin, Boran Sekeroglu, Greta S. P. Mok
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10.1371/journal.pone.0226265

PLOS ONE Intra-individual correlations between quantitative THK-5351 PET and MRI-derived cortical volume in Alzheimer’s disease differ according to disease severity and amyloid positivity
December 13, 2019 Ji Eun Park, Jessica Yun, Sang Joon Kim, Woo Hyun Shim, Jungsu S. Oh, Minyoung Oh, Jee Hoon Roh, Sang Won Seo, Seung Jun Oh, Jae Seung Kim
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PLOS ONE Pupillometry evaluation of melanopsin retinal ganglion cell function and sleep-wake activity in pre-symptomatic Alzheimer’s disease
December 10, 2019 Angela J. Oh, Giulia Amore, William Sultan, Samuel Asanad, Jason C. Park, Martina Romagnoli, Chiara La Morgia, Rustum Karanjia, Michael G. Harrington, Alfredo A. Sadun
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10.1371/journal.pone.0225417

PLOS ONE C5aR agonist enhances phagocytosis of fibrillar and non-fibrillar Aβ amyloid and preserves memory in a mouse model of familial Alzheimer’s disease
December 6, 2019 Elena Panayiotou, Eleni Fella, Savanna Andreou, Revekka Papacharalambous, Petroula Gerasimou, Paul Costeas, Stella Angeli, Ioanna Kousiappa, Savvas Papacostas, Theodoros Kyriakides
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Steven HWG

PLOS ONE Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients
November 15, 2019 Cassandra DeMarshall, Esther Oh, Rahil Kheirkhah, Frederick Sieber, Henrik Zetterberg, Kaj Blennow, Robert G. Nagele
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Elien Dumon

PLOS ONE Bacillus Calmette-Guérin (BCG) therapy lowers the incidence of Alzheimer’s disease in bladder cancer patients
November 7, 2019 Ofer N. Gofrit, Benjamin Y. Klein, Irun R. Cohen, Tamir Ben-Hur, Charles L. Greenblatt, Hervé Bercovier
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10.1371/journal.pone.0222977

PLOS ONE No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer’s disease
October 3, 2019 Therese M. Gilligan, Francesca Sibilia, Dervla Farrell, Declan Lyons, Seán P. Kennelly, Arun L. W. Bokde
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Sabine van Erp

PLOS ONE Comorbidity of age-related macular degeneration with Alzheimer’s disease: A histopathologic case-control study
September 30, 2019 Gordon J. Smilnak, John R. Deans, P. Murali Doraiswamy, Sandra Stinnett, Heather E. Whitson, Eleonora M. Lad
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Gerd Altmann

PLOS ONE Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer’s patients
September 23, 2019 Judith A. Potashkin, Virginie Bottero, Jose A. Santiago, James P. Quinn
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PLOS ONE Amyloid-β PET—Correlation with cerebrospinal fluid biomarkers and prediction of Alzheimer´s disease diagnosis in a memory clinic
August 20, 2019 Ebba Gløersen Müller, Trine Holt Edwin, Caroline Stokke, Sigrid Stensby Navelsaker, Almira Babovic, Nenad Bogdanovic, Anne Brita Knapskog, Mona Elisabeth Revheim

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PLOS ONE announced the Early Diagnosis and Treatment of Alzheimer’s Disease Call for Papers on May 15, 2019.

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