Biology & Life Sciences

Blood-Brain Barrier Biology in Health and Pathology

Published June 10, 2020 Calls for Papers Collections

The strict regulation of the microenvironment by the blood-brain barrier is a key component of central nervous system function. Changes in the structure and function of this unique and dynamic interface are implicated in a variety of neurological disorders, and the high selectivity of the blood-brain barrier presents both challenges and opportunities for therapeutic intervention in the central nervous system. This PLOS ONE Collection highlights research into the structure, function, development, and modeling of the blood-brain barrier in health and pathology, as well as novel approaches to interact with the central nervous system via the blood-brain barrier.

Image Credit: Jeffery J. Iliff

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Guest Editors
PLOS ONE Collection

Guest Editors

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Peter Searson

PLOS ONE Dr. Peter Searson
September 13, 2019 Guest Editor, PLOS ONE
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Eric Shusta

PLOS ONE Dr. Eric Shusta
September 13, 2019 Guest Editor, PLOS ONE
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Patricia Steeg

PLOS ONE Dr. Patricia Steeg
September 13, 2019 Guest Editor, PLOS ONE
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David Liebeskind

PLOS ONE Dr. David Liebeskind
September 13, 2019 Guest Editor, PLOS ONE

PLOS ONE Collection

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10.1371/journal.pone.0234001

PLOS ONE Increased blood-brain barrier hyperpermeability coincides with mast cell activation early under cuprizone administration
June 8, 2020 John Shelestak, Naveen Singhal, Lana Frankle, Riely Tomor, Sarah Sternbach, Jennifer McDonough, Ernest Freeman, Robert Clements
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10.1371/journal.pone.0227463

PLOS ONE Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake
May 29, 2020 Erika Liktor-Busa, Kiera T. Blawn, Kathryn L. Kellohen, Beth M. Wiese, Vani Verkhovsky, Jared Wahl, Anjali Vivek, Seph M. Palomino, Thomas P. Davis, Todd W. Vanderah, Tally M. Largent-Milnes
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Marshal Fox

PLOS ONE Using old antibiotics to treat ancient bacterium—β-lactams for Bacillus anthracis meningitis
February 13, 2020 Assa Sittner, Amir Ben-Shmuel, Itai Glinert, Elad Bar-David, Josef Schlomovitz, David Kobiler, Shay Weiss, Haim Levy
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Ben Brahim Mohammed

PLOS ONE Patients with chronic autoimmune demyelinating polyneuropathies exhibit cognitive deficits which might be associated with CSF evidence of blood-brain barrier disturbance
February 4, 2020 Yavor Yalachkov, Valerie Uhlmann, Johannes Bergmann, Dilara Soydaş, Stefan Frisch, Marion Behrens, Christian Foerch, Johannes Gehrig
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Brittany Schmidt

PLOS ONE Insulin BBB pharmacokinetics in young apoE male and female transgenic mice
January 31, 2020 Elizabeth M. Rhea, Eileen Ruth S. Torres, Jacob Raber, William A. Banks

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PLOS announced the Blood-Brain Barrier Biology in Health and Pathology Call for Papers on September 13, 2019.

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