Biology & Life Sciences

COVID-19 pandemic (2019-21)

Updated April 15, 2021 Curated Collections

This Collection of articles highlights all content published across the PLOS journals relating to the COVID-19 pandemic in 2019-21. PLOS is committed to disseminating research as quickly as possible, particularly in public health emergencies. All articles published in any PLOS journal are Open Access free of charge to all readers.

Image Credit: US NIH/Public domain (CC-0) and Senado Federal/Flickr (CC-BY)

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Clinical Epidemiology and Care

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Fig 4. Use of the Biomark-based protocol to detect mutations associated with SARS-CoV-2 variants. by JFassy et al., CC BY 4.0

PLOS ONE Versatile and flexible microfluidic qPCR test for high-throughput SARS-CoV-2 and cellular response detection in nasopharyngeal swab samples
April 14, 2021 Julien Fassy, Caroline Lacoux, Sylvie Leroy, Latifa Noussair, Sylvain Hubac, Aurélien Degoutte, Georges Vassaux, Vianney Leclercq, David Rouquié, Charles-Hugo Marquette, Martin Rottman, Patrick Touron, Antoinette Lemoine, Jean-Louis Herrmann, Pascal Barbry, Jean-Louis Nahon, Laure-Emmanuelle Zaragosi, Bernard Mari

The emergence and quick spread of SARS-CoV-2 has pointed at a low capacity response for testing large populations in many countries, in…
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Fig 1. by Ravindra et al., CC BY 4.0

PLOS ONE Impact of COVID-19 on the hospitalization, treatment, and outcomes of intracerebral and subarachnoid hemorrhage in the United States
April 14, 2021 Vijay M. Ravindra, Ramesh Grandhi, Alen Delic, Samuel Hohmann, Ernie Shippey, David Tirschwell, Jennifer A. Frontera, Shadi Yaghi, Jennifer J. Majersik, Mohammad Anadani, Adam de Havenon

Objective: To examine the outcomes of adult patients with spontaneous intracranial and subarachnoid hemorrhage diagnosed with comorbid…
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Fig 1. Proportion of states with high COVID-19 rates among those in the low and high mask adherence quartiles in the preceding month. by Fischer et al., CC BY 4.0

PLOS ONE Mask adherence and rate of COVID-19 across the United States
April 14, 2021 Charlie B. Fischer, Nedghie Adrien, Jeremiah J. Silguero, Julianne J. Hopper, Abir I. Chowdhury, Martha M. Werler

Mask wearing has been advocated by public health officials as a way to reduce the spread of COVID-19. In the United States, policies on…
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Fig 2. Close up of port on scent wheel. by Essler et al., CC BY 4.0

PLOS ONE Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study
April 14, 2021 Jennifer L. Essler, Sarah A. Kane, Pat Nolan, Elikplim H. Akaho, Amalia Z. Berna, Annemarie DeAngelo, Richard A. Berk, Patricia Kaynaroglu, Victoria L. Plymouth, Ian D. Frank, Susan R. Weiss, Audrey R. Odom John, Cynthia M. Otto

While the world awaits a widely available COVID-19 vaccine, availability of testing is limited in many regions and can be further…
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Novel Coronavirus SARS-Cov-2 by NIAID, CC-0 Public Domain

PLOS ONE Low risk of SARS-CoV-2 in blood transfusion
April 13, 2021 Michael Owusu, Augustina Angelina Sylverken, Philip El-Duah, Nana Kwame Ayisi-Boateng, Richmond Yeboah, Eric Adu, Jesse Asamoah, Michael Frimpong, Japhet Senyo, Godfred Acheampong, Mohamed Mutocheluh, John Amuasi, Ellis Owusu-Dabo, Yaw Adu-Sarkodie, Richard Odame Phillips

Background: The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2),…
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Fig 1. Viral copies and Ct values in mask and NPS samples. by Sriraman et al., CC BY 4.0

PLOS ONE Non-invasive adapted N-95 mask sampling captures variation in viral particles expelled by COVID-19 patients: Implications in understanding SARS-CoV2 transmission
April 12, 2021 Kalpana Sriraman, Ambreen Shaikh, Swapneil Parikh, Shreevatsa Udupa, Nirjhar Chatterjee, Jayanthi Shastri, Nerges Mistry

Infectious respiratory particles expelled by SARS-CoV-2 positive patients are attributed to be the key driver of COVID-19 transmission.…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Knowledge, preventive behaviors and risk perception of the COVID-19 pandemic: A cross-sectional study in Turkish health care workers
April 9, 2021 Tufan Arslanca, Cihan Fidan, Mine Daggez, Polat Dursun

The coronavirus disease 2019 (COVID-19) outbreak spread to over 100 countries with a total of 100,000 cases during the first week of March…
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Fig 2. by Rasmussen et al., CC BY 4.0

PLOS ONE SARS-CoV-2 infection dynamics in Denmark, February through October 2020: Nature of the past epidemic and how it may develop in the future
April 9, 2021 Steen Rasmussen, Michael Skytte Petersen, Niels Høiby

Background: Initially, the relative sizes of the asymptomatic and the symptomatic infected populations were not known for the COVID-19…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Similar incidence of coronavirus disease 2019 (COVID-19) in patients with rheumatic diseases with and without hydroxychloroquine therapy
April 8, 2021 Juan Macías, Paz González-Moreno, Esther Sánchez-García, Ramón Morillo-Verdugo, José J. Pérez-Venegas, Ana Pinilla, MªMar Macho, MªVictoria Martínez, Alejandro González-Serna, Anaïs Corma, Luis M. Real, Juan A. Pineda

Background: Hydroxychloroquine is not efficacious as post-exposure prophylaxis against coronavirus disease 2019 (COVID-19). It is not known…
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Fig 2. Distribution of ordinal scale on day one, prior to treatment, day 14, and day 28. by Mehta et al., CC BY 4.0

PLOS ONE What about tocilizumab? A retrospective study from a NYC Hospital during the COVID-19 outbreak
April 8, 2021 Monica Mehta, Lawrence J. Purpura, Thomas H. McConville, Matthew J. Neidell, Michaela R. Anderson, Elana J. Bernstein, Donald E. Dietz, Justin Laracy, Shauna H. Gunaratne, Emily Happy Miller, Jennifer Cheng, Jason Zucker, Shivang S. Shah, Shaoli Chaudhuri, Christian A. Gordillo, Shreena R. Patel, Tai Wei Guo, Lara E. Karaaslan, Ran Reshef, Benjamin A. Miko, Joan M. Bathon, Marcus R. Pereira, Anne-Catrin Uhlemann, Michael T. Yin, Magdalena E. Sobieszczyk

Background: Tocilizumab, an interleukin-6 receptor blocker, has been used in the inflammatory phase of COVID-19, but its impact independent…
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Fig 1. Map of a portion of the underground sewer pipeline network of Belmont, Massachusetts (thanks to PeopleGIS for granting permission to publish this MapsOnline site.). by Nourinejad et al., CC BY 4.0

PLOS ONE Placing sensors in sewer networks: A system to pinpoint new cases of coronavirus
April 8, 2021 Mehdi Nourinejad, Oded Berman, Richard C. Larson

We consider a proposed system that would place sensors in a number of wastewater manholes in a community in order to detect genetic…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Prevalence of SARS-COV-2 positivity in 516 German intensive care and emergency physicians studied by seroprevalence of antibodies National Covid Survey Germany (NAT-COV-SURV)
April 8, 2021 Detlef Kindgen-Milles, Timo Brandenburger, Julian F. W. Braun, Corvin Cleff, Kian Moussazadeh, Ingo Mrosewski, Jörg Timm, Dietmar Wetzchewald

Healthcare personnel are at risk to aquire the corona virus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome…
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Fig 1. Days from admission to the appearance of neurologic events. by Flores-Silva et al., CC BY 4.0

PLOS ONE Neurologic manifestations in hospitalized patients with COVID-19 in Mexico City
April 8, 2021 Fernando Daniel Flores-Silva, Miguel García-Grimshaw, Sergio Iván Valdés-Ferrer, Alma Poema Vigueras-Hernández, Rogelio Domínguez-Moreno, Dioselina Panamá Tristán-Samaniego, Anaclara Michel-Chávez, Alejandra González-Duarte, Felipe A. Vega-Boada, Isael Reyes-Melo, Amado Jiménez-Ruiz, Oswaldo Alan Chávez-Martínez, Daniel Rebolledo-García, Osvaldo Alexis Marché-Fernández, Samantha Sánchez-Torres, Guillermo García-Ramos, Carlos Cantú-Brito, Erwin Chiquete

Background: The coronavirus disease 2019 (COVID-19) is a systemic entity that frequently implies neurologic features at presentation and…
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Fig 2. Antigen kinetics determined for specimens from 38 COVID-19 patients at different post-symptom-onset periods assessed by two antigen assays according to cut-off index values, the AFIAS COVID-19 Ag and the ichroma^TM COVID-19 Ag. by Kweon et al., CC BY 4.0

PLOS ONE Evaluation of rapid SARS-CoV-2 antigen tests, AFIAS COVID-19 Ag and ichroma COVID-19 Ag, with serial nasopharyngeal specimens from COVID-19 patients
April 8, 2021 Oh Joo Kweon, Yong Kwan Lim, Hye Ryoun Kim, Yoojeong Choi, Min-Chul Kim, Seong-Ho Choi, Jin-Won Chung, Mi-Kyung Lee

We evaluated the diagnostic accuracy of two newly developed, point-of-care, rapid antigen tests (RATs) for detecting SARS-CoV-2, the AFIAS…
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Fig 2. Comparison of COVID-19 and post-COVID-19 symptoms. by Mahmud et al., CC BY 4.0

PLOS ONE Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary care center of Bangladesh
April 8, 2021 Reaz Mahmud, Md. Mujibur Rahman, Mohammad Aftab Rassel, Farhana Binte Monayem, S. K. Jakaria Been Sayeed, Md. Shahidul Islam, Mohammed Monirul Islam

Background: Post-coronavirus disease (COVID-19) syndrome includes persistence of symptoms beyond viral clearance and fresh development of…
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Fig 1. Comparative assessment of 168 serum samples from SARS-CoV-2-infected individuals by ELISA and lateral flow immunoassay. by Sweeney et al., CC BY 4.0

PLOS ONE Clinical utility of targeted SARS-CoV-2 serology testing to aid the diagnosis and management of suspected missed, late or post-COVID-19 infection syndromes: Results from a pilot service implemented during the first pandemic wave
April 7, 2021 Nicola Sweeney, Blair Merrick, Rui Pedro Galão, Suzanne Pickering, Alina Botgros, Harry D. Wilson, Adrian W. Signell, Gilberto Betancor, Mark Kia Ik Tan, John Ramble, Neophytos Kouphou, Sam Acors, Carl Graham, Jeffrey Seow, Eithne MacMahon, Stuart J. D. Neil, Michael H. Malim, Katie Doores, Sam Douthwaite, Rahul Batra, Gaia Nebbia, Jonathan D. Edgeworth

During the first wave of the global COVID-19 pandemic the clinical utility and indications for SARS-CoV-2 serological testing were not…
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Fig 1. Odd ratio of A (red square) and O group (green circle) from our study and the ones found in the literature. by Muñoz-Culla et al., CC BY 4.0

PLOS ONE O group is a protective factor for COVID19 in Basque population
April 7, 2021 Maider Muñoz-Culla, Andres Roncancio-Clavijo, Bruno Martínez, Miriam Gorostidi-Aicua, Luis Piñeiro, Arkaitz Azkune, Ainhoa Alberro, Jorge Monge-Ruiz, Tamara Castillo-Trivino, Alvaro Prada, David Otaegui

ABO blood groups have recently been related to COVID19 infection. In the present work, we performed this analysis using data from 412…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Association of ABO blood groups with presentation and outcomes of confirmed SARS CoV-2 infection: A prospective study in the largest COVID-19 dedicated hospital in Bangladesh
April 7, 2021 Reaz Mahmud, Mohammad Aftab Rassel, Farhana Binte Monayem, S. K. Jakaria Been Sayeed, Md Shahidul Islam, Mohammed Monirul Islam, Mohammad Abdullah Yusuf, Sabrina Rahman, K. M. Nazmul Islam, Imran Mahmud, Mohammad Zaid Hossain, Ahmed Hossain Chowdhury, A. K. M. Humayon Kabir, Kazi Gias Uddin Ahmed, Md. Mujibur Rahman

Background: Globally, studies have shown conflicting results regarding the association of blood groups with SARS CoV-2 infection.…
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Fig 3. SARS-CoV-2 intrahost single nucleotide variant (iSNV) diversity. by Valesano et al., CC BY 4.0

PLOS Pathogens Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts
April 7, 2021 Andrew L. Valesano, Kalee E. Rumfelt, Derek E. Dimcheff, Christopher N. Blair, William J. Fitzsimmons, Joshua G. Petrie, Emily T. Martin, Adam S. Lauring

Analysis of SARS-CoV-2 genetic diversity within infected hosts can provide insight into the generation and spread of new viral variants…
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Fig 7. Galbraith plot identified eight outlier studies as potential sources of heterogeneity. by Islam et al., CC BY 4.0

PLOS ONE Prevalence and characteristics of fever in adult and paediatric patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis of 17515 patients
April 6, 2021 Md Asiful Islam, Shoumik Kundu, Sayeda Sadia Alam, Tareq Hossan, Mohammad Amjad Kamal, Rosline Hassan

Background: Coronavirus disease 2019 (COVID-19), a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 started…
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Fig 1. Seroprevalence of antibodies to SARS-CoV-2. by Hiki et al., CC BY 4.0

PLOS ONE Seroprevalence of anti-SARS-CoV-2 antibodies in Japanese COVID-19 patients
April 6, 2021 Makoto Hiki, Yoko Tabe, Tomohiko Ai, Yuya Matsue, Norihiro Harada, Kiichi Sugimoto, Yasushi Matsushita, Masakazu Matsushita, Mitsuru Wakita, Shigeki Misawa, Mayumi Idei, Takashi Miida, Naoto Tamura, Kazuhisa Takahashi, Toshio Naito

Objectives: To determine the seroprevalence of anti-SARS-CoV-2 IgG and IgM antibodies in symptomatic Japanese COVID-19 patients. Methods:…
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Fig 1. Correlation between IL-6 and NLR. by Garcia-Gordillo et al., CC BY 4.0

PLOS ONE COVID-IRS: A novel predictive score for risk of invasive mechanical ventilation in patients with COVID-19
April 5, 2021 José Antonio Garcia-Gordillo, Antonio Camiro-Zúñiga, Mercedes Aguilar-Soto, Dalia Cuenca, Arturo Cadena-Fernández, Latife Salame Khouri, Jesica Naanous Rayek, Moises Mercado, The ARMII Study Group

Background: Coronavirus disease 2019 (COVID-19) is a systemic disease that can rapidly progress into acute respiratory failure and death.…
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Fig 1. Kaplan-Meier curves for cumulative survival probability during hospitalization. by He et al., CC BY 4.0

PLOS ONE Clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection: A multi-center study
April 5, 2021 Shengyang He, Wenlong Liu, Mingyan Jiang, Peng Huang, Zhi Xiang, Dingding Deng, Ping Chen, Lihua Xie

Objective: To understand the clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection (CDBC), and…
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Fig 2. The average Ct value of E, RdRP and ORF 1ab gene in different clinical samples. by Sharma et al., CC BY 4.0

PLOS ONE Comparative analysis of various clinical specimens in detection of SARS-CoV-2 using rRT-PCR in new and follow up cases of COVID-19 infection: Quest for the best choice
April 5, 2021 Kuldeep Sharma, Pragya Aggarwala, Deepa Gandhi, Anuniti Mathias, Priyanka Singh, Somya Sharma, Sanjay Singh Negi, Anudita Bhargava, Padma Das, Ujjwala Gaikwad, Archana Wankhede, Ajoy Behra, Nitin M. Nagarkar

Background: An appropriate specimen is of paramount importance in Real Time reverse transcription-polymerase chain reaction (rRT-PCR) based…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Evaluation of the Abbott BinaxNOW rapid antigen test for SARS-CoV-2 infection in children: Implications for screening in a school setting
April 5, 2021 Neeraj Sood, Rashmi Shetgiri, Anna Rodriguez, Dianna Jimenez, Sonia Treminino, Amanda Daflos, Paul Simon

Background: Rapid antigen tests hold much promise for use in the school environment. However, the performance of these tests in…
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Fig 2. Log-log plot of study seroprevalence (x-axis) vs two cumulative case estimators for each study. by Byambasuren et al., CC BY 4.0

PLOS ONE Comparison of seroprevalence of SARS-CoV-2 infections with cumulative and imputed COVID-19 cases: Systematic review
April 2, 2021 Oyungerel Byambasuren, Claudia C. Dobler, Katy Bell, Diana Patricia Rojas, Justin Clark, Mary-Louise McLaws, Paul Glasziou

Background: Accurate seroprevalence estimates of SARS-CoV-2 in different populations could clarify the extent to which current testing…
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Fig 1. Daily cumulative number of first reported case COVID-19 and school closure. by Nazif-Muñoz et al., CC BY 4.0

PLOS ONE The global viralization of policies to contain the spreading of the COVID-19 pandemic: Analyses of school closures and first reported cases
April 1, 2021 José Ignacio Nazif-Muñoz, Sebastián Peña, Youssef Oulhote

Background: On January 30th 2020, the World Health Organization (WHO) declared a international health emergency due to the unprecedented…
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Fig 1. Numbers of confirmed COVID-19 cases across geographical areas of Thailand as of July 4, 2020. by Nopsopon et al., CC BY 4.0

PLOS ONE Seroprevalence of hospital staff in a province with zero COVID-19 cases
April 1, 2021 Tanawin Nopsopon, Krit Pongpirul, Korn Chotirosniramit, Wutichai Jakaew, Chuenkhwan Kaewwijit, Sawan Kanchana, Narin Hiransuthikul

Background: COVID-19 seroprevalence data, particularly in less developed countries with a relatively low incidence, has been scant. We…
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Fig 1. Ranking of counties based on health indicators. by Bhowmik et al., CC BY 4.0

PLOS ONE A comprehensive analysis of COVID-19 transmission and mortality rates at the county level in the United States considering socio-demographics, health indicators, mobility trends and health care infrastructure attributes
April 1, 2021 Tanmoy Bhowmik, Sudipta Dey Tirtha, Naveen Chandra Iraganaboina, Naveen Eluru

Background: Several research efforts have evaluated the impact of various factors including a) socio-demographics, (b) health indicators,…
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Fig 2. COVID-19 outbreak examples. by Gros et al., CC BY 4.0

PLOS ONE Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities
April 1, 2021 Claudius Gros, Roser Valenti, Lukas Schneider, Benedikt Gutsche, Dimitrije Marković

The distinct ways the COVID-19 pandemic has been unfolding in different countries and regions suggest that local societal and governmental…
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Fig 1. Overview of the proposed diagnostic system for COVID-19. by Han et al., CC BY 4.0

PLOS ONE Semi-supervised learning for an improved diagnosis of COVID-19 in CT images
April 1, 2021 Chang Hee Han, Misuk Kim, Jin Tae Kwak

Coronavirus disease 2019 (COVID-19) has been spread out all over the world. Although a real-time reverse-transcription polymerase chain…
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Fig 1. A weekly timeline of the COVID-19 epidemic. by Kasztelewicz et al., CC BY 4.0

PLOS ONE Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland
April 1, 2021 Beata Kasztelewicz, Katarzyna Janiszewska, Julia Burzyńska, Emilia Szydłowska, Marek Migdał, Katarzyna Dzierżanowska-Fangrat

Data on the prevalence of the SARS-CoV-2 antibody in healthcare workers (HCWs) is scarce, especially in pediatric settings. The purpose of…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS ONE Baseline cardiometabolic profiles and SARS-CoV-2 infection in the UK Biobank
April 1, 2021 Ryan J. Scalsky, Yi-Ju Chen, Karan Desai, Jeffery R. O’Connell, James A. Perry, Charles C. Hong

Background: SARS-CoV-2 is a rapidly spreading coronavirus responsible for the Covid-19 pandemic, which is characterized by severe…
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Fig 1. ROC curves mechanical ventilation prediction (AUC 68%). by Yu et al., CC BY 4.0

PLOS ONE Machine learning methods to predict mechanical ventilation and mortality in patients with COVID-19
April 1, 2021 Limin Yu, Alexandra Halalau, Bhavinkumar Dalal, Amr E. Abbas, Felicia Ivascu, Mitual Amin, Girish B. Nair

Background: The Coronavirus disease 2019 (COVID-19) pandemic has affected millions of people across the globe. It is associated with a high…
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Fig 1. Map showing all health facilities in Bulawayo district and highlighting the 24 sampled health facilities. by Rusakaniko et al., CC BY 4.0

PLOS Neglected Tropical Diseases SARS-CoV-2 Serological testing in frontline health workers in Zimbabwe
March 31, 2021 Simbarashe Rusakaniko, Elopy Nemele Sibanda, Takafira Mduluza, Paradzayi Tagwireyi, Zephaniah Dhlamini, Chiratidzo Ellen Ndhlovu, Precious Chandiwana, Shingirai Chiwambutsa, Rivka May Lim, Fiona Scott, Lindiwe Majele Sibanda, Francisca Mutapi

Background: In order to protect health workers from SARS-CoV-2, there is need to characterise the different types of patient facing health…
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Fig 1. Number of COVID-19 hospitalizations in Belgium (BE) and the Netherlands (NL) including an overview of the national preventive measures taken during first epidemic wave, February-July 2020. by Verberk et al., CC BY 4.0

PLOS ONE Experiences and needs of persons living with a household member infected with SARS-CoV-2: A mixed method study
March 31, 2021 Janneke D. M. Verberk, Sibyl A. Anthierens, Sarah Tonkin-Crine, Herman Goossens, John Kinsman, Marieke L. A. de Hoog, Julia A. Bielicki, Patricia C. J. L. Bruijning-Verhagen, Nina H. Gobat

Background: Households are important sites for transmission of SARS-CoV-2 and preventive measures are recommended. This study aimed to 1)…
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Fig 1. Score plot: PC2 vs. PC1. by Lusczek et al., CC BY 4.0

PLOS ONE Characterizing COVID-19 clinical phenotypes and associated comorbidities and complication profiles
March 31, 2021 Elizabeth R. Lusczek, Nicholas E. Ingraham, Basil S. Karam, Jennifer Proper, Lianne Siegel, Erika S. Helgeson, Sahar Lotfi-Emran, Emily J. Zolfaghari, Emma Jones, Michael G. Usher, Jeffrey G. Chipman, R. Adams Dudley, Bradley Benson, Genevieve B. Melton, Anthony Charles, Monica I. Lupei, Christopher J. Tignanelli

Purpose: Heterogeneity has been observed in outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19). Identification of…
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Fig 1. Study model. by Feldman et al., CC BY 4.0

PLOS ONE Endotracheal intubation of COVID-19 patients by paramedics using a box barrier: A randomized crossover manikin study
March 31, 2021 Oren Feldman, Nir Samuel, Noa Kvatinsky, Ravit Idelman, Raz Diamand, Itai Shavit

Background: In the prehospital setting, endotracheal intubation (ETI) may be required to secure the coronavirus disease 2019 (COVID-19)…
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Fig 4. Sunburst diagram of medication pathways with individual regimens grouped by order of initiation. by McPadden et al., CC BY 4.0

PLOS ONE Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
March 31, 2021 Jacob McPadden, Frederick Warner, H. Patrick Young, Nathan C. Hurley, Rebecca A. Pulk, Avinainder Singh, Thomas J. S. Durant, Guannan Gong, Nihar Desai, Adrian Haimovich, Richard Andrew Taylor, Murat Gunel, Charles S. Dela Cruz, Shelli F. Farhadian, Jonathan Siner, Merceditas Villanueva, Keith Churchwell, Allen Hsiao, Charles J. Torre Jr, Eric J. Velazquez, Roy S. Herbst, Akiko Iwasaki, Albert I. Ko, Bobak J. Mortazavi, Harlan M. Krumholz, Wade L. Schulz

Objective: Severe acute respiratory syndrome virus (SARS-CoV-2) has infected millions of people worldwide. Our goal was to identify risk…
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Fig 2. Distribution by age intervals of the patients admitted for COVID-19 during the first and second waves. by Iftimie et al., CC BY 4.0

PLOS ONE First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain
March 31, 2021 Simona Iftimie, Ana F. López-Azcona, Immaculada Vallverdú, Salvador Hernández-Flix, Gabriel de Febrer, Sandra Parra, Anna Hernández-Aguilera, Francesc Riu, Jorge Joven, Natàlia Andreychuk, Gerard Baiges-Gaya, Frederic Ballester, Marc Benavent, José Burdeos, Alba Català, Èric Castañé, Helena Castañé, Josep Colom, Mireia Feliu, Xavier Gabaldó, Diana Garrido, Pedro Garrido, Joan Gil, Paloma Guelbenzu, Carolina Lozano, Francesc Marimon, Pedro Pardo, Isabel Pujol, Antoni Rabassa, Laia Revuelta, Marta Ríos, Neus Rius-Gordillo, Elisabet Rodríguez-Tomàs, Wojciech Rojewski, Esther Roquer-Fanlo, Noèlia Sabaté, Anna Teixidó, Carlos Vasco, Jordi Camps, Antoni Castro

Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with a first wave during…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC BY 4.0

PLOS ONE Functional outcomes in the inpatient rehabilitation setting following severe COVID-19 infection
March 31, 2021 Cameron Spencer Olezene, Elizabeth Hansen, Hannah K. Steere, Joseph T. Giacino, Ginger R. Polich, Joanne Borg-Stein, Ross D. Zafonte, Jeffrey C. Schneider

Objective: To characterize the functional impairments of a cohort of patients undergoing inpatient rehabilitation after surviving severe…
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Untitled by Inbaraj et al., CC BY 4.0

PLOS ONE Seroprevalence of COVID-19 infection in a rural district of South India: A population-based seroepidemiological study
March 31, 2021 Leeberk Raja Inbaraj, Carolin Elizabeth George, Sindhulina Chandrasingh

Objectives: We aimed to estimate the seroprevalence of COVID-19 in a rural district of South India, six months after the index case.…
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Fig 3. by Berger et al., CC BY 4.0

PLOS ONE Diagnostic accuracy of two commercial SARS-CoV-2 antigen-detecting rapid tests at the point of care in community-based testing centers
March 31, 2021 Alice Berger, Marie Therese Ngo Nsoga, Francisco Javier Perez-Rodriguez, Yasmine Abi Aad, Pascale Sattonnet-Roche, Angèle Gayet-Ageron, Cyril Jaksic, Giulia Torriani, Erik Boehm, Ilona Kronig, Jilian A. Sacks, Margaretha de Vos, Frédérique Jacquerioz Bausch, François Chappuis, Adriana Renzoni, Laurent Kaiser, Manuel Schibler, Isabella Eckerle

Objectives: Determine the diagnostic accuracy of two antigen-detecting rapid diagnostic tests (Ag-RDT) for SARS-CoV-2 at the point of care…
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Fig 2. The simulation model structure representing the dynamic interactions of different health state of COVID-19. by Ansah et al., CC BY 4.0

PLOS ONE The effectiveness of public health interventions against COVID-19: Lessons from the Singapore experience
March 30, 2021 John P. Ansah, David Bruce Matchar, Sean Lam Shao Wei, Jenny G. Low, Ahmad Reza Pourghaderi, Fahad Javaid Siddiqui, Tessa Lui Shi Min, Aloysius Chia Wei-Yan, Marcus Eng Hock Ong

Background: In dealing with community spread of COVID-19, two active interventions have been attempted or advocated—containment, and…
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Fig 2. Adherence to behavioral NPIs to mitigate Covid-19 and subsequent mortality increases over three months in eight countries: (A) Percentage of adult population with strong or very strong self-reported adherence on June 1, 2020; (B) Percentage increase in reported Covid-19 mortality from June 1 to August 31, 2020. by Margraf et al., CC BY 4.0

PLOS ONE Adherence to behavioral Covid-19 mitigation measures strongly predicts mortality
March 30, 2021 Jürgen Margraf, Julia Brailovskaia, Silvia Schneider

In the absence of vaccines or causal therapies, behavioral measures such as wearing face masks and maintaining social distance are central…
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Fig 1. Results of the measurement of SARS-CoV-2 RNA standards using the GeneSoC^®. by Watanabe et al., CC BY 4.0

PLOS ONE Evaluation of the basic assay performance of the GeneSoc^® rapid PCR testing system for detection of severe acute respiratory syndrome coronavirus 2
March 30, 2021 Ryosuke Watanabe, Satomi Asai, Hidehumi Kakizoe, Hirofumi Saeki, Atsuko Masukawa, Miki Miyazawa, Kazumi Ohtagawa, Mend-Amar Ravzanaaadii, Mika Doi, Haruyo Atsumi, Kazuo Umezawa, Hayato Miyachi

In the ongoing coronavirus disease 2019 (COVID-19) pandemic, PCR has been widely used for screening patients displaying relevant symptoms.…
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Fig 1. Comparison of sampling into VTM vs. NSLB. by Erster et al., CC BY 4.0

PLOS ONE Improved sensitivity, safety, and rapidity of COVID-19 tests by replacing viral storage solution with lysis buffer
March 30, 2021 Oran Erster, Omer Shkedi, Gil Benedek, Eyal Zilber, Itay Varkovitzky, Rachel Shirazi, Dorit Oriya Shorka, Yuval Cohen, Tzahi Bar, Rafi Yechieli, Michal Tepperberg Oikawa, Dana Venkert, Michal Linial, Esther Oiknine-Djian, Michal Mandelboim, Zvi Livneh, Gilat Shenhav-Saltzman, Ella Mendelson, Dana Wolf, Moran Szwarcwort-Cohen, Orna Mor, Yair Lewis, Danny Zeevi

Conducting numerous, rapid, and reliable PCR tests for SARS-CoV-2 is essential for our ability to monitor and control the current COVID-19…
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Fig 1. ROC curve for lab parameters. by Malik et al., CC BY 4.0

PLOS ONE Thyroid function analysis in COVID-19: A retrospective study from a single center
March 30, 2021 Jahanzeb Malik, Asmara Malik, Muhammad Javaid, Tayyaba Zahid, Uzma Ishaq, Muhammad Shoaib

Background and objective: Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the…
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Fig 1. SARS-CoV and SARS-CoV-2 replication kinetics in hAEC cultures. by V'kovski et al., CC BY 4.0

PLOS Biology Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium
March 29, 2021 Philip V’kovski, Mitra Gultom, Jenna N. Kelly, Silvio Steiner, Julie Russeil, Bastien Mangeat, Elisa Cora, Joern Pezoldt, Melle Holwerda, Annika Kratzel, Laura Laloli, Manon Wider, Jasmine Portmann, Thao Tran, Nadine Ebert, Hanspeter Stalder, Rune Hartmann, Vincent Gardeux, Daniel Alpern, Bart Deplancke, Volker Thiel, Ronald Dijkman

Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major…
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Fig 4. Difference between mean serial and generation intervals and realized incubation periods. by Torneri et al., CC BY 4.0

PLOS Computational Biology On realized serial and generation intervals given control measures: The COVID-19 pandemic case
March 29, 2021 Andrea Torneri, Peter Libin, Gianpaolo Scalia Tomba, Christel Faes, James G. Wood, Niel Hens

The SARS-CoV-2 pathogen is currently spreading worldwide and its propensity for presymptomatic and asymptomatic transmission makes it…
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Fig 2. Contact rate matrix. by Lee et al., CC BY 4.0

PLOS ONE The effect of control measures on COVID-19 transmission in South Korea
March 29, 2021 Taeyong Lee, Hee-Dae Kwon, Jeehyun Lee

Countries around the world have taken control measures to mitigate the spread of COVID-19, including Korea. Social distancing is…
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Untitled by Arias-Reyes et al., CC BY 4.0

PLOS ONE Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent
March 29, 2021 Christian Arias-Reyes, Favio Carvajal-Rodriguez, Liliana Poma-Machicao, Fernanda Aliaga-Raduán, Danuzia A. Marques, Natalia Zubieta-DeUrioste, Roberto Alfonso Accinelli, Edith M. Schneider-Gasser, Gustavo Zubieta-Calleja, Mathias Dutschmann, Jorge Soliz

The coronavirus disease 2019 (COVID-19) outbreak in North, Central, and South America has become the epicenter of the current pandemic. We…
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Fig 1. by Wang et al., CC BY 4.0

PLOS ONE Transmission and control pressure analysis of the COVID-19 epidemic situation using multisource spatio-temporal big data
March 29, 2021 Fangxiong Wang, Ziqian Tan, Zaihui Yu, Siqi Yao, Changfeng Guo

Taking the Guangdong-Hong Kong-Macao Greater Bay Area as the research area, this paper used OD cluster analysis based on Baidu migration…
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Fig 2. SARS-CoV-2 imported and circulating clades. by Zuckerman et al., CC BY 4.0

PLOS ONE Genomic variation and epidemiology of SARS-CoV-2 importation and early circulation in Israel
March 26, 2021 Neta S. Zuckerman, Efrat Bucris, Yaron Drori, Oran Erster, Danit Sofer, Rakefet Pando, Ella Mendelson, Orna Mor, Michal Mandelboim

Severe acute respiratory disease coronavirus 2 (SARS-CoV-2) which causes corona virus disease (COVID-19) was first identified in Wuhan,…
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Fig 2. User interface in the cell phone application observed in the home unit. by Motta et al., CC BY 4.0

PLOS ONE An emergency system for monitoring pulse oximetry, peak expiratory flow, and body temperature of patients with COVID-19 at home: Development and preliminary application
March 26, 2021 Leonardo Pereira Motta, Pedro Paulo Ferreira da Silva, Bruno Max Borguezan, Jorge Luis Machado do Amaral, Lucimar Gonçalves Milagres, Márcio Neves Bóia, Marcos Rochedo Ferraz, Roberto Mogami, Rodolfo Acatauassú Nunes, Pedro Lopes de Melo

Background: COVID-19 is characterized by a rapid change in the patient’s condition, with major changes occurring over a few days. We aimed…
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Fig 2. Cumulative incidence plot of death and recovery in the total population, separated by age group. by Nijman et al., CC BY 4.0

PLOS ONE Risk factors for in-hospital mortality in laboratory-confirmed COVID-19 patients in the Netherlands: A competing risk survival analysis
March 26, 2021 Gerine Nijman, Maike Wientjes, Jordache Ramjith, Nico Janssen, Jacobien Hoogerwerf, Evertine Abbink, Marc Blaauw, Ton Dofferhoff, Marjan van Apeldoorn, Karin Veerman, Quirijn de Mast, Jaap ten Oever, Wouter Hoefsloot, Monique H. Reijers, Reinout van Crevel, Josephine S. van de Maat

Background: To date, survival data on risk factors for COVID-19 mortality in western Europe is limited, and none of the published survival…
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Untitled by Jin et al., CC BY 4.0

PLOS Pathogens Sex- and age-specific clinical and immunological features of coronavirus disease 2019
March 26, 2021 Shengwei Jin, Hui An, Tong Zhou, Ting Li, Mengzhen Xie, Saijing Chen, Chengshui Chen, Binyu Ying, Zhangye Xu, Xiaokun Li, Ming Li

To simultaneously determine clinical and immunological responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection…
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Fig 2. SARS-CoV-2 evolution. by Rolland and Gilbert, CC BY 4.0

PLOS Pathogens Sieve analysis to understand how SARS-CoV-2 diversity can impact vaccine protection
March 25, 2021 Morgane Rolland, Peter B. Gilbert

…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE ICU outcomes and survival in patients with severe COVID-19 in the largest health care system in central Florida
March 25, 2021 Eduardo Oliveira, Amay Parikh, Arnaldo Lopez-Ruiz, Maria Carrilo, Joshua Goldberg, Martin Cearras, Khaled Fernainy, Sonja Andersen, Luis Mercado, Jian Guan, Hammad Zafar, Patricia Louzon, Amy Carr, Natasha Baloch, Richard Pratley, Scott Silverstry, Vincent Hsu, Jason Sniffen, Victor Herrera, Neil Finkler

Background: Observational studies have consistently described poor clinical outcomes and increased ICU mortality in patients with severe…
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Fig 4. SARS-CoV-2 infection risk map (grid) of Rio de Janeiro state, displaying the city of Rio de Janeiro (capital, left) and the city of Niteroi (right). by Dantas et al., CC BY 4.0

PLOS ONE App-based symptom tracking to optimize SARS-CoV-2 testing strategy using machine learning
March 25, 2021 Leila F. Dantas, Igor T. Peres, Leonardo S. L. Bastos, Janaina F. Marchesi, Guilherme F. G. de Souza, João Gabriel M. Gelli, Fernanda A. Baião, Paula Maçaira, Silvio Hamacher, Fernando A. Bozza

Background: Tests are scarce resources, especially in low and middle-income countries, and the optimization of testing programs during a…
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Untitled by Pozderac and Skinner, CC BY 4.0

PLOS ONE Superspreading of SARS-CoV-2 in the USA
March 25, 2021 Calvin Pozderac, Brian Skinner

A number of epidemics, including the SARS-CoV-1 epidemic of 2002-2004, have been known to exhibit superspreading, in which a small…
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Fig 1. Age and sex-stratification of the outcomes (CPAP/NIV, ICU admission, and death) in SARS-CoV-2 patients. by Gili et al., CC BY 4.0

PLOS ONE SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy
March 25, 2021 Tommaso Gili, Giampaolo Benelli, Elisabetta Buscarini, Ciro Canetta, Giuseppe La Piana, Guido Merli, Alessandro Scartabellati, Giovanni Viganò, Roberto Sfogliarini, Giovanni Melilli, Roberto Assandri, Daniele Cazzato, Davide Sebastiano Rossi, Susanna Usai, Guido Caldarelli, Irene Tramacere, Germano Pellegata, Giuseppe Lauria

We report onset, course, correlations with comorbidities, and diagnostic accuracy of nasopharyngeal swab in 539 individuals suspected to…
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Fig 1. Cumulative in-, outpatient and total hospitalization case deficit for several conditions in the German-wide Helios hospital network during the Covid-19 pandemic. by Bollmann et al., CC BY 4.0

PLOS ONE Utilization of in- and outpatient hospital care in Germany during the Covid-19 pandemic insights from the German-wide Helios hospital network
March 25, 2021 Andreas Bollmann, Sven Hohenstein, Vincent Pellissier, Katharina Stengler, Peter Reichardt, Jörg-Peter Ritz, Holger Thiele, Michael A. Borger, Gerhard Hindricks, Andreas Meier-Hellmann, Ralf Kuhlen

Background: During the early phase of the Covid-19 pandemic, reductions of hospital admissions with a focus on emergencies have been…
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cat by Sean MacEntee, CC BY 2.0

PLOS ONE Neutralizing antibodies for SARS-CoV-2 in stray animals from Rio de Janeiro, Brazil
March 25, 2021 Helver Gonçalves Dias, Maria Eduarda Barreto Resck, Gabriela Cardoso Caldas, Alessandro Fioretti Resck, Natália Valente da Silva, Aline Marcele Vieira dos Santos, Thiago das Chagas Sousa, Maria Halina Ogrzewalska, Marilda Mendonça Siqueira, Alex Pauvolid-Corrêa, Flavia Barreto dos Santos

The epidemic of coronavirus disease 2019 (COVID-19), caused by a novel Betacoronavirus named severe acute respiratory syndrome coronavirus…
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Fig 1. Vaccine constructs and vaccination schedule. by Kurup et al., CC BY 4.0

PLOS Pathogens Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model
March 25, 2021 Drishya Kurup, Delphine C. Malherbe, Christoph Wirblich, Rachael Lambert, Adam J. Ronk, Leila Zabihi Diba, Alexander Bukreyev, Matthias J. Schnell

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although…
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Fig 1. Daily new cases of COVID-19 in New Zealand from 26 February to 31 May 2020, split into cases with a recent history of international travel (blue) and those without (orange). by James et al., CC BY 4.0

PLOS ONE Model-free estimation of COVID-19 transmission dynamics from a complete outbreak
March 24, 2021 Alex James, Michael J. Plank, Shaun Hendy, Rachelle N. Binny, Audrey Lustig, Nic Steyn

New Zealand had 1499 cases of COVID-19 before eliminating transmission of the virus. Extensive contract tracing during the outbreak has…
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Fig 2. by Neelon et al., CC BY 4.0

PLOS ONE Spatial and temporal trends in social vulnerability and COVID-19 incidence and death rates in the United States
March 24, 2021 Brian Neelon, Fedelis Mutiso, Noel T. Mueller, John L. Pearce, Sara E. Benjamin-Neelon

Background: Socially vulnerable communities may be at higher risk for COVID-19 outbreaks in the US. However, no prior studies examined…
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Fig 4. Linear trajectories of IL-6. by Manenti et al., CC BY 4.0

PLOS ONE Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study
March 24, 2021 Lucio Manenti, Umberto Maggiore, Enrico Fiaccadori, Tiziana Meschi, Anna Degli Antoni, Antonio Nouvenne, Andrea Ticinesi, Nicoletta Cerundolo, Beatrice Prati, Marco Delsante, Ilaria Gandoflini, Lorenzo Donghi, Micaela Gentile, Maria Teresa Farina, Vincenzo Oliva, Cristina Zambrano, Giuseppe Regolisti, Alessandra Palmisano, Caterina Caminiti, Enrico Cocchi, Carlo Ferrari, Leonardo V. Riella, Paolo Cravedi, Licia Peruzzi

Objectives: Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed. We hypothesized that colchicine, by…
PLOS ONE Symptoms and symptom clusters associated with SARS-CoV-2 infection in community-based populations: Results from a statewide epidemiological study
March 24, 2021 Brian E. Dixon, Kara K. Wools-Kaloustian, William F. Fadel, Thomas J. Duszynski, Constantin Yiannoutsos, Paul K. Halverson, Nir Menachemi

Background: Prior studies examining symptoms of COVID-19 are primarily descriptive and measured among hospitalized individuals.…
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Fig 3. Box plot (left) and ROC curves for Energy (right). by Aragón-Benedí et al., CC BY 4.0

PLOS ONE Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study
March 24, 2021 Cristian Aragón-Benedí, Pablo Oliver-Forniés, Felice Galluccio, Ece Yamak Altinpulluk, Tolga Ergonenc, Abdallah El Sayed Allam, Carlos Salazar, Mario Fajardo-Pérez

Introduction: The analysis of heart rate variability (HRV) has proven to be an important tool for the management of autonomous nerve system…
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Fig 1. WA State DOH COVID-19 confirmed cases by age: 3/1/2020-4/19/2020. by Malmgren et al., CC BY 4.0

PLOS ONE Continued proportional age shift of confirmed positive COVID-19 incidence over time to children and young adults: Washington State March—August 2020
March 24, 2021 Judith Malmgren, Boya Guo, Henry G. Kaplan

Background: As the coronavirus (COVID-19) epidemic passed initial infection peak in Washington State, phased re-opening lifted stay-at-home…
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Fig 1. ROC curve of multivariable logistic regression model. by Betti et al., CC BY 4.0

PLOS ONE Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study
March 24, 2021 Marta Betti, Marinella Bertolotti, Daniela Ferrante, Annalisa Roveta, Carolina Pelazza, Fabio Giacchero, Serena Penpa, Costanza Massarino, Tatiana Bolgeo, Antonella Cassinari, Marco Mussa, Guido Chichino, Antonio Maconi

Background: Individual differences in susceptibility to SARS-CoV-2 infection, symptomatology and clinical manifestation of COVID-19 have…
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Fig 1. BMI is higher in positive versus negative individuals and is associated with severe respiratory symptoms. by Frasca et al., CC BY 4.0

PLOS ONE Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients
March 24, 2021 Daniela Frasca, Lisa Reidy, Carolyn Cray, Alain Diaz, Maria Romero, Kristin Kahl, Bonnie B. Blomberg

SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant…
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Fig 2. Forest plot that shows the weighted pooled proportion of asymptomatic SARS-CoV-2 infection using available studies, 2020. by Alene et al., CC BY 4.0

PLOS ONE Magnitude of asymptomatic COVID-19 cases throughout the course of infection: A systematic review and meta-analysis
March 23, 2021 Muluneh Alene, Leltework Yismaw, Moges Agazhe Assemie, Daniel Bekele Ketema, Belayneh Mengist, Bekalu Kassie, Tilahun Yemanu Birhan

Background: Asymptomatic SARS-CoV-2 infections are responsible for potentially significant transmission of COVID-19. Worldwide, a number of…
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Fig 4. Age and comorbidity—adjusted distribution of fatality among reported hospitalized series with >100 patients and Alicante cohort, stratified according to the management approach. by Andrés et al., CC BY 4.0

PLOS ONE Fatality and risk features for prognosis in COVID-19 according to the care approach – a retrospective cohort study
March 23, 2021 Mariano Andrés, Jose-Manuel Leon-Ramirez, Oscar Moreno-Perez, José Sánchez-Payá, Ignacio Gayá, Violeta Esteban, Isabel Ribes, Diego Torrus-Tendero, Pilar González-de-la-Aleja, Pere Llorens, Vicente Boix, Joan Gil, Esperanza Merino, on behalf of COVID19-ALC research group

Introduction: This study analyzed the impact of a categorized approach, based on patients’ prognosis, on major outcomes and explanators in…
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Fig 1. by Zou et al., CC BY 4.0

PLOS ONE The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT
March 23, 2021 Jia-Ni Zou, Liu Sun, Bin-Ru Wang, You Zou, Shan Xu, Yong-Jun Ding, Li-Jun Shen, Wen-Cai Huang, Xiao-Jing Jiang, Shi-Ming Chen

The characteristics and evolution of pulmonary fibrosis in patients with coronavirus disease 2019 (COVID-19) have not been adequately…
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Fig 1. Relative levels of absorbance from day 0 to day 28. by Bläckberg et al.g, CC BY 4.0

PLOS ONE Antibody kinetics and clinical course of COVID-19 a prospective observational study
March 22, 2021 Anna Bläckberg, Nils Fernström, Emma Sarbrant, Magnus Rasmussen, Torgny Sunnerhagen

Background: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19.…
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Fig 1. Epidemiological curve of the first COVID-19 wave in Basel-City and region, Switzerland. by Stange et al., CC BY 4.0

PLOS Pathogens SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event
March 19, 2021 Madlen Stange, Alfredo Mari, Tim Roloff, Helena MB Seth-Smith, Michael Schweitzer, Myrta Brunner, Karoline Leuzinger, Kirstine K. Søgaard, Alexander Gensch, Sarah Tschudin-Sutter, Simon Fuchs, Julia Bielicki, Hans Pargger, Martin Siegemund, Christian H. Nickel, Roland Bingisser, Michael Osthoff, Stefano Bassetti, Rita Schneider-Sliwa, Manuel Battegay, Hans H. Hirsch, Adrian Egli

The first case of SARS-CoV-2 in Basel, Switzerland was detected on February 26th 2020. We present a phylogenetic study to explore viral…
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Fig 3. Contour plots for R(∞) (top), Imax (middle) and the mean time of infection (bottom) as a function of parameters for the well-mixed population. by Di Lauro et al., CC BY 4.0

PLOS Computational Biology Optimal timing of one-shot interventions for epidemic control
March 18, 2021 Francesco Di Lauro, István Z. Kiss, Joel C. Miller

The interventions and outcomes in the ongoing COVID-19 pandemic are highly varied. The disease and the interventions both impose costs and…
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Fig 1. Comparison of dynamic trajectories of six laboratory parameters in COVID-19 patients between two age groups. by Hu et al., CC BY 4.0

PLOS ONE The effect of age on the clinical and immune characteristics of critically ill patients with COVID-19: A preliminary report
March 18, 2021 Chunling Hu, Junlu Li, Xia Xing, Jing Gao, Shilong Zhao, Lihua Xing

Background: In December 2019, a new disease named coronavirus disease 2019 (COVID-19) was occurred. Patients who are critically ill with…
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Fig 2. Mobility statistics in Tokyo at 15:00: a. (March 13, 2020), b. (April 23, 2020). by Kajitani and Hatayama, CC BY 4.0

PLOS ONE Explaining the effective reproduction number of COVID-19 through mobility and enterprise statistics: Evidence from the first wave in Japan
March 18, 2021 Yoshio Kajitani, Michinori Hatayama

This study uses mobility statistics combined with business census data for the eight Japanese prefectures with the highest coronavirus…
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Fig 1. Time curves of platelet count, six-point ordinal scale score and oxygenation index. by Zhu et al., CC BY 4.0

PLOS ONE Association between thrombocytopenia and 180-day prognosis of COVID-19 patients in intensive care units: A two-center observational study
March 18, 2021 Yuan Zhu, Jing Zhang, Yiming Li, Fang Liu, Qing Zhou, Zhiyong Peng

Background: Thrombocytopenia has been proved to be associated with hospital mortality in patients with severe acute respiratory syndrome…
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Fig 2. Duration of symptoms prior to symptom duration prior to a positive SARS-CoV-2 test among Heathcare Workers (HCW), outpatients, and inpatients, ^a p value 0.04. by McEllistrem et al., CC BY 4.0

PLOS ONE SARS-CoV-2 is associated with high viral loads in asymptomatic and recently symptomatic healthcare workers
March 18, 2021 M. Catherine McEllistrem, Cornelius J. Clancy, Deanna J. Buehrle, Nina Singh, Aaron Lucas, Valerie Sirianni, Brooke K. Decker

Background: Healthcare workers (HCW) are at increased risk of SARS-CoV-2 infection from both patients and other HCW with coronavirus…
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Fig 2. Outcome (A) and mortality density (B) distribution by age disaggregated data and gender of the study population (n = 162,045). by de Souza et al., CC BY 4.0

PLOS ONE On the analysis of mortality risk factors for hospitalized COVID-19 patients: A data-driven study using the major Brazilian database
March 18, 2021 Fernanda Sumika Hojo de Souza, Natália Satchiko Hojo-Souza, Ben Dêivide de Oliveira Batista, Cristiano Maciel da Silva, Daniel Ludovico Guidoni

Background: Brazil became the epicenter of the COVID-19 epidemic in a brief period of a few months after the first officially registered…
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Fig 1. Repeated measurements of six different laboratory parameter from onset of symptoms until discharge between moderately ill and severely ill COVID-19 patients. by Pouw et al., CC BY 4.0

PLOS ONE Clinical characteristics and outcomes of 952 hospitalized COVID-19 patients in The Netherlands: A retrospective cohort study
March 18, 2021 Niels Pouw, Josephine van de Maat, Karin Veerman, Jaap ten Oever, Nico Janssen, Evertine Abbink, Monique Reijers, Quirijn de Mast, Wouter Hoefsloot, Reinout van Crevel, Kitty Slieker, Marjan van Apeldoorn, Marc Blaauw, Anton Dofferhoff, Jacobien Hoogerwerf

Objective: To describe clinical characteristics, disease course and outcomes in a large and well-documented cohort of hospitalized COVID-19…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE The association of COVID-19 occurrence and severity with the use of angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers in patients with hypertension
March 18, 2021 Mingfei Li, Ying Wang, Ndindam Ndiwane, Michelle B. Orner, Natalia Palacios, Brant Mittler, Dan Berlowitz, Lewis E. Kazis, Weiming Xia

Background: A number of studies have reported the association between the use of angiotensin-converting enzyme inhibitor (ACEI) and…
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Fig 1. Nasopharyngeal and tracheal SARS-CoV-2 viral loads in infected cynomolgus macaques treated by a placebo or hydroxychloroquine ± azithromycin. by Gonçalves et al., CC BY 4.0

PLOS Computational Biology SARS-CoV-2 viral dynamics in non-human primates
March 17, 2021 Antonio Gonçalves, Pauline Maisonnasse, Flora Donati, Mélanie Albert, Sylvie Behillil, Vanessa Contreras, Thibaut Naninck, Romain Marlin, Caroline Solas, Andres Pizzorno, Julien Lemaitre, Nidhal Kahlaoui, Olivier Terrier, Raphael Ho Tsong Fang, Vincent Enouf, Nathalie Dereuddre-Bosquet, Angela Brisebarre, Franck Touret, Catherine Chapon, Bruno Hoen, Bruno Lina, Manuel Rosa Calatrava, Xavier de Lamballerie, France Mentré, Roger Le Grand, Sylvie van der Werf, Jérémie Guedj

Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the…
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Fig 1. Standardized diagnostic algorithm for patients with suspected or confirmed COVID-19 associated ARDS. by Lahmer et al., CC BY 4.0

PLOS ONE Invasive pulmonary aspergillosis in critically ill patients with severe COVID-19 pneumonia: Results from the prospective AspCOVID-19 study
March 17, 2021 Tobias Lahmer, Silja Kriescher, Alexander Herner, Kathrin Rothe, Christoph D. Spinner, Jochen Schneider, Ulrich Mayer, Michael Neuenhahn, Dieter Hoffmann, Fabian Geisler, Markus Heim, Gerhard Schneider, Roland M. Schmid, Wolfgang Huber, Sebastian Rasch

Background: Superinfections, including invasive pulmonary aspergillosis (IPA), are well-known complications of critically ill patients with…
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Fig 1. Cumulative incidence of COVID-19 over a selected period in 15 countries in Western Europe (log scale). by Locatelli et al., CC BY 4.0

PLOS ONE Estimating the basic reproduction number for COVID-19 in Western Europe
March 17, 2021 Isabella Locatelli, Bastien Trächsel, Valentin Rousson

Objective: To estimate the basic reproduction number (R0) for COVID-19 in Western Europe. Methods: Data (official statistics) on the…
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Untitled by Zaferani Arani et al., CC BY 4.0

PLOS ONE Understanding the clinical and demographic characteristics of second coronavirus spike in 192 patients in Tehran, Iran: A retrospective study
March 19, 2021 Hamid Zaferani Arani, Giti Dehghan Manshadi, Hesam Adin Atashi, Aida Rezaei Nejad, Seyyed Mojtaba Ghorani, Soheila Abolghasemi, Maryam Bahrani, Homayoon Khaledian, Pantea Bozorg Savodji, Mohammad Hoseinian, Atefe Kazemzade Bejandi, Shahla Abolghasemi

During the last months of the coronavirus pandemic, with all those public restrictions and health interventions, the transmission of…
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Fig 1. Frequency of MOCHA abnormalities in patients with thrombotic endpoints, intubation and ICU admission. by Alabyad et al., CC BY 4.0

PLOS ONE Validation of an admission coagulation panel for risk stratification of COVID-19 patients
March 19, 2021 Darwish Alabyad, Srikant Rangaraju, Michael Liu, Rajeel Imran, Christine L. Kempton, Milad Sharifpour, Sara C. Auld, Manila Gaddh, Roman Sniecinski, Cheryl L. Maier, Jeannette Guarner, Alexander Duncan, Fadi Nahab

Background: There is limited data on the markers of coagulation and hemostatic activation (MOCHA) profile in Coronavirus disease 2019…
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Fig 3. Age distribution by treatment group. by Stewart et al., CC BY 4.0

PLOS ONE COVID-19 Evidence Accelerator: A parallel analysis to describe the use of Hydroxychloroquine with or without Azithromycin among hospitalized COVID-19 patients
March 17, 2021 Mark Stewart, Carla Rodriguez-Watson, Adem Albayrak, Julius Asubonteng, Andrew Belli, Thomas Brown, Kelly Cho, Ritankar Das, Elizabeth Eldridge, Nicolle Gatto, Alice Gelman, Hanna Gerlovin, Stuart L. Goldberg, Eric Hansen, Jonathan Hirsch, Yuk-Lam Ho, Andrew Ip, Monika Izano, Jason Jones, Amy C. Justice, Reyna Klesh, Seth Kuranz, Carson Lam, Qingqing Mao, Samson Mataraso, Robertino Mera, Daniel C. Posner, Jeremy A. Rassen, Anna Siefkas, Andrew Schrag, Georgia Tourassi, Andrew Weckstein, Frank Wolf, Amar Bhat, Susan Winckler, Ellen V. Sigal, Jeff Allen

Background: The COVID-19 pandemic remains a significant global threat. However, despite urgent need, there remains uncertainty surrounding…
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Fig 5. Predictions for air freight in the U.S. by Meng et al., CC BY 4.0

PLOS ONE Impact of different control policies for COVID-19 outbreak on the air transportation industry: A comparison between China, the U.S. and Singapore
March 16, 2021 Fanyu Meng, Wenwu Gong, Jun Liang, Xian Li, Yiping Zeng, Lili Yang

Many countries have been implementing various control measures with different strictness levels to prevent the coronavirus disease 2019…
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Fig 2. Distribution of 264 patients with SARS-CoV-2 infection according to age groups and mortality rates. by De Vito et al., CC BY 4.0

PLOS ONE Predictors of infection, symptoms development, and mortality in people with SARS-CoV-2 living in retirement nursing homes
March 16, 2021 Andrea De Vito, Vito Fiore, Elija Princic, Nicholas Geremia, Catello Mario Panu Napodano, Alberto Augusto Muredda, Ivana Maida, Giordano Madeddu, Sergio Babudieri

Introduction: Since the start of the pandemic, millions of people have been infected, with thousands of deaths. Many foci worldwide have…
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Fig 1. Flowchart of inclusion and exclusion criteria. by Kheir et al., CC BY 4.0

PLOS ONE Higher albumin levels on admission predict better prognosis in patients with confirmed COVID-19
March 16, 2021 Matthew Kheir, Farah Saleem, Christy Wang, Amardeep Mann, Jimmy Chua

Background: Research surrounding COVID-19 (coronavirus disease 2019) is rapidly increasing, including the study of biomarkers for…
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Untitled by Schuler et al., CC BY 4.0

PLOS ONE Accurate point-of-care serology tests for COVID-19
March 16, 2021 Charles F. Schuler IV, Carmen Gherasim, Kelly O’Shea, David M. Manthei, Jesse Chen, Don Giacherio, Jonathan P. Troost, James L. Baldwin, James R. Baker Jr

Background: As COVID-19 vaccines become available, screening individuals for prior COVID-19 infection and vaccine response in point-of-care…
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Fig 1. Types and number of comorbidities among 492 COVID-19 patients with comorbidities admitted in Lagos isolation centers from January 27 to July 6, 2020. by Osibogun et al., CC BY 4.0

PLOS ONE Outcomes of COVID-19 patients with comorbidities in southwest Nigeria
March 15, 2021 Akin Osibogun, Mobolanle Balogun, Akin Abayomi, Jide Idris, Yetunde Kuyinu, Oluwakemi Odukoya, Ololade Wright, Remi Adeseun, Bamidele Mutiu, Babatunde Saka, Nike Osa, Dayo Lajide, Ismael Abdus-Salam, Bodunrin Osikomaiya, Oluwatosin Onasanya, Bisola Adebayo, Yewande Oshodi, Sunday Adesola, Olu Adejumo, Olufemi Erinoso, Hussein Abdur-Razzaq, Abimbola Bowale, Kingsley Akinroye

Background: Data on the comorbidities that result in negative outcomes for people with COVID-19 are currently scarce for African…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Laboratory biomarkers of COVID-19 disease severity and outcome: Findings from a developing country
March 15, 2021 Tigist W. Leulseged, Ishmael S. Hassen, Birhanu T. Ayele, Yakob G. Tsegay, Daniel S. Abebe, Mesay G. Edo, Endalkachew H. Maru, Wuletaw C. Zewde, Lydia K. Naylor, Dejene F. Semane, Menayit T. Dresse, Bereket B. Tezera

Aim: To identify laboratory biomarkers that predict disease severity and outcome among COVID-19 patients admitted to the Millennium…
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Untitled by MacLean et al., CC BY 4.0

PLOS Biology Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen
March 12, 2021 Oscar A. MacLean, Spyros Lytras, Steven Weaver, Joshua B. Singer, Maciej F. Boni, Philippe Lemey, Sergei L. Kosakovsky Pond, David L. Robertson

Virus host shifts are generally associated with novel adaptations to exploit the cells of the new host species optimally. Surprisingly,…
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Fig 1. Level of knowledge on the transmission, prevention and practice of precautionary measure of COVID-19. by Defar et al., CC BY 4.0

PLOS ONE Knowledge, practice and associated factors towards the prevention of COVID-19 among high-risk groups: A cross-sectional study in Addis Ababa, Ethiopia
March 11, 2021 Atkure Defar, Gebeyaw Molla, Saro Abdella, Masresha Tessema, Muhammed Ahmed, Ashenif Tadele, Fikresilassie Getachew, Bezawit Hailegiorgis, Eyasu Tigabu, Sabit Ababor, Ketema Bizuwork, Asefa Deressa, Geremew Tasaw, Adisu Kebede, Daniel Melese, Andargachew Gashu, Kirubel Eshetu, Adamu Tayachew, Mesfin Wossen, Abduilhafiz Hassen, Shambel Habebe, Zewdu Assefa, Aschalew Abayneh, Ebba Abate, Getachew Tollera

Background: Coronavirus disease (COVID-19) is a highly transmittable virus that continues to disrupt livelihoods, particularly those of…
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Table 4. Matrix of binary Jaccard similarity coefficients between clinical signs and the COVID-19 status. by Saegerman et al., CC BY 4.0

PLOS ONE Clinical decision support tool for diagnosis of COVID-19 in hospitals
March 11, 2021 Claude Saegerman, Allison Gilbert, Anne-Françoise Donneau, Marjorie Gangolf, Anh Nguvet Diep, Cécile Meex, Sébastien Bontems, Marie-Pierre Hayette, Vincent D’Orio, Alexandre Ghuysen

Background: The coronavirus infectious disease 19 (COVID-19) pandemic has resulted in significant morbidities, severe acute respiratory…
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Fig 5. Trial sequential analysis for remdesivir versus control (standard care or placebo) on all-cause mortality. by Juul et al., CC BY 4.0

PLOS ONE Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
March 11, 2021 Sophie Juul, Emil Eik Nielsen, Joshua Feinberg, Faiza Siddiqui, Caroline Kamp Jørgensen, Emily Barot, Johan Holgersson, Niklas Nielsen, Peter Bentzer, Areti Angeliki Veroniki, Lehana Thabane, Fanlong Bu, Sarah Klingenberg, Christian Gluud, Janus Christian Jakobsen

Background: COVID-19 is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world.…
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Fig 2. Transmission of COVID-19 infection among close contact households. by Gomaa et al., CC BY 4.0

PLOS Pathogens Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort
March 11, 2021 Mokhtar R. Gomaa, Amira S. El Rifay, Mahmoud Shehata, Ahmed Kandeil, Mina Nabil Kamel, Mohamed A. Marouf, Mohamed GabAllah, Ahmed El Taweel, Ahmed E. Kayed, Omnia Kutkat, Yassmin Moatasim, Sara H. Mahmoud, Noura M. Abo Shama, Mohamed El Sayes, Ahmed Mostafa, Rabeh El-Shesheny, Pamela P. McKenzie, Richard J. Webby, Ghazi Kayali, Mohamed A. Ali

SARS-CoV-2 virus is transmitted in closed settings to people in contact with COVID-19 patients such as healthcare workers and household…
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Fig 1. ND COVID-19 Dashboard Fall 2020 (https://here.nd.edu/our-approach/dashboard/fall-2020-data/) with data for all (diagnostic and surveillance) on-campus COVID-19 tests posted as of December 16, 2020. by Kasturi Haldar, CC BY 4.0

PLOS Pathogens The pivot: Fighting Irish fighting COVID-19
March 10, 2021 Kasturi Haldar

…
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Fig 2. Characteristics of chest computed tomography scan in COVID-19 patients. by Liu et al., CC BY 4.0

PLOS Neglected Tropical Diseases Epidemiological and clinical features in patients with coronavirus disease 2019 outside of Wuhan, China: Special focus in asymptomatic patients
March 10, 2021 Ping Liu, Ruichao Niu, Jie Chen, Yuling Tang, Wenfang Tang, Linyan Xu, Juntao Feng

Objectives: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan City and rapidly spread across the world. The clinical…
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Fig 1. Flowchart of the study. by Gülbay et al., CC BY 4.0

PLOS ONE A CT radiomics analysis of COVID-19-related ground-glass opacities and consolidation: Is it valuable in a differential diagnosis with other atypical pneumonias?
March 10, 2021 Mutlu Gülbay, Bahadır Orkun Özbay, Bökebatur Ahmet Raşit Mendi, Aliye Baştuğ, Hürrem Bodur

Purpose: To evaluate the discrimination of parenchymal lesions between COVID-19 and other atypical pneumonia (AP) by using only radiomics…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Prevalence of COVID-19 in adolescents and youth compared with older adults in states experiencing surges
March 10, 2021 Barbara Rumain, Moshe Schneiderman, Allan Geliebter

Purpose: There has been considerable controversy regarding susceptibility of adolescents (10–19 years) and youth (15–24 years) to COVID-19.…
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Fig 1. The CORC score by number of points. by Kline et al., CC BY 4.0

PLOS ONE Clinical prediction rule for SARS-CoV-2 infection from 116 U.S. emergency departments 2-22-2021
March 10, 2021 Jeffrey A. Kline, Carlos A. Camargo Jr., D. Mark Courtney, Christopher Kabrhel, Kristen E. Nordenholz, Thomas Aufderheide, Joshua J. Baugh, David G. Beiser, Christopher L. Bennett, Joseph Bledsoe, Edward Castillo, Makini Chisolm-Straker, Elizabeth M. Goldberg, Hans House, Stacey House, Timothy Jang, Stephen C. Lim, Troy E. Madsen, Danielle M. McCarthy, Andrew Meltzer, Stephen Moore, Craig Newgard, Justine Pagenhardt, Katherine L. Pettit, Michael S. Pulia, Michael A. Puskarich, Lauren T. Southerland, Scott Sparks, Danielle Turner-Lawrence, Marie Vrablik, Alfred Wang, Anthony J. Weekes, Lauren Westafer, John Wilburn

Objectives: Accurate and reliable criteria to rapidly estimate the probability of infection with the novel coronavirus-2 that causes the…
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Fig 1. We consider that an individual goes through different phases of infection/disease, which is represented by a SEIR-like state machine. by Libin et al., CC BY 4.0

PLOS Computational Biology Assessing the feasibility and effectiveness of household-pooled universal testing to control COVID-19 epidemics
March 9, 2021 Pieter J. K. Libin, Lander Willem, Timothy Verstraeten, Andrea Torneri, Joris Vanderlocht, Niel Hens

Outbreaks of SARS-CoV-2 are threatening the health care systems of several countries around the world. The initial control of SARS-CoV-2…
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Fig 1. Schematic presentation of the sampling procedure for the study conducted among health professionals in public health facilities of Gamo zone, southern Ethiopia, 2020. by Mersha et al., CC BY 4.0

PLOS ONE Health professionals practice and associated factors towards precautionary measures for COVID-19 pandemic in public health facilities of Gamo zone, southern Ethiopia: A cross-sectional study
March 9, 2021 Abera Mersha, Shitaye Shibiru, Meseret Girma, Gistane Ayele, Agegnehu Bante, Mekidim Kassa, Sintayehu Abebe, Misgun Shewangizaw

Introduction: Coronavirus disease-2019 (COVID-19) is a highly contagious acute respiratory disease, which caused by a novel coronavirus.…
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Fig 3. Total compliance during healthcare interactions and when performing AGPs. by Ashinyo et al., CC BY 4.0

PLOS ONE Infection prevention and control compliance among exposed healthcare workers in COVID-19 treatment centers in Ghana: A descriptive cross-sectional study
March 9, 2021 Mary Eyram Ashinyo, Stephen Dajaan Dubik, Vida Duti, Kingsley Ebenezer Amegah, Anthony Ashinyo, Brian Adu Asare, Angela Ama Ackon, Samuel Kaba Akoriyea, Patrick Kuma-Aboagye

Compliance with infection prevention and control (IPC) protocols is critical in minimizing the risk of coronavirus disease (COVID-19)…
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Fig 2. Block diagram of the COVID-19 SEIR model with shield immunity control. by Xu et al., CC BY 4.0

PLOS ONE Control strategies for COVID-19 epidemic with vaccination, shield immunity and quarantine: A metric temporal logic approach
March 5, 2021 Zhe Xu, Bo Wu, Ufuk Topcu

Ever since the outbreak of the COVID-19 epidemic, various public health control strategies have been proposed and tested against the…
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Fig 1. by Brault et al., CC BY 4.0

PLOS Computational Biology Group testing as a strategy for COVID-19 epidemiological monitoring and community surveillance
March 4, 2021 Vincent Brault, Bastien Mallein, Jean-François Rupprecht

We propose an analysis and applications of sample pooling to the epidemiologic monitoring of COVID-19. We first introduce a model of the…
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Fig 2. by Richard et al., CC BY 4.0

PLOS Computational Biology Age-structured non-pharmaceutical interventions for optimal control of COVID-19 epidemic
March 4, 2021 Quentin Richard, Samuel Alizon, Marc Choisy, Mircea T. Sofonea, Ramsès Djidjou-Demasse

In an epidemic, individuals can widely differ in the way they spread the infection depending on their age or on the number of days they…
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Novel Coronavirus SARS-CoV-2 Spike Protein by NIH, CC-0 Public Domain

PLOS Medicine Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis
March 4, 2021 Aaron Leong, Joanne B. Cole, Laura N. Brenner, James B. Meigs, Jose C. Florez, Josep M. Mercader

Background: Epidemiological studies report associations of diverse cardiometabolic conditions including obesity with COVID-19 illness, but…
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Fig 1. Graphical abstract. by Refat et al., CC BY 4.0

PLOS ONE Quercetin/Zinc complex and stem cells: A new drug therapy to ameliorate glycometabolic control and pulmonary dysfunction in diabetes mellitus: Structural characterization and genetic studies
March 4, 2021 Moamen S. Refat, Reham Z. Hamza, Abdel Majid A. Adam, Hosam A. Saad, Adil A. Gobouri, Fatimah S. Al-Harbi, Fawziah A. Al-Salmi, Tariq Altalhi, Samy M. El-Megharbel

Medicinal uses and applications of metals and their complexes are of increasing clinical and commercial importance. The ligation behavior…
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Fig 3. Relation between force of infection, sensitivity and specificity in the Colombo data. by Alexander et al., CC BY 4.0

PLOS ONE Estimating force of infection from serologic surveys with imperfect tests
March 4, 2021 Neal Alexander, Mabel Carabali, Jacqueline K. Lim

Background: The force of infection, or the rate at which susceptible individuals become infected, is an important public health measure for…
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Fig 1. by Vahid S. Bokharaie, CC BY 4.0

PLOS ONE A study on the effects of containment policies and vaccination on the spread of SARS-CoV-2
March 4, 2021 Vahid S. Bokharaie

This paper presents a method to predict the spread of the SARS-CoV-2 in a population with a known age-structure, and then, to quantify the…
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Fig 1. Immunofluorescence assay (IFA) against SARS-CoV-2 proteins. by Tso et al., CC BY 4.0

PLOS ONE Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma
March 4, 2021 For Yue Tso, Salum J. Lidenge, Lisa K. Poppe, Phoebe B. Peña, Sara R. Privatt, Sydney J. Bennett, John R. Ngowi, Julius Mwaiselage, Michael Belshan, Jacob A. Siedlik, Morgan A. Raine, Juan B. Ochoa, Julia Garcia-Diaz, Bobby Nossaman, Lyndsey Buckner, W. Mark Roberts, Matthew J. Dean, Augusto C. Ochoa, John T. West, Charles Wood

Background: Neutralizing-antibody (nAb) is the major focus of most ongoing COVID-19 vaccine trials. However, nAb response against…
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Fig 1. Schematic of Easy Check COVID-19 IgM/IgG^TM lateral flow assay. by Higgins et al., CC BY 4.0

PLOS ONE Longitudinal SARS-CoV-2 antibody study using the Easy Check COVID-19 IgM/IgG™ lateral flow assay
March 4, 2021 Renee L. Higgins, Stephen A. Rawlings, Jamie Case, Florence Y. Lee, Clarence W. Chan, Bethany Barrick, Zoe C. Burger, Kiang-Teck J. Yeo, Dena Marrinucci

Since the initial identification of the novel coronavirus SARS-CoV-2 in December of 2019, researchers have raced to understand its…
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Fig 3. Cumulative frequency: Number of days between onset of symptoms and follow-up consultation at ambulatory follow-up unit (AFU). by Chevallier Lugon et al., CC BY 4.0

PLOS ONE Novel outpatient management of mild to moderate COVID-19 spares hospital capacity and safeguards patient outcome: The Geneva PneumoCoV-Ambu study
March 4, 2021 Chloé Chevallier Lugon, Mikaela Smit, Julien Salamun, Meriem Abderrahmane, Olivia Braillard, Mayssam Nehme, Frédérique Jacquerioz Bausch, Idris Guessous, Hervé Spechbach

Background: Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes coronavirus disease (COVID-19), is…
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Novel Coronavirus SARS-CoV-2 Spike Protein by NIH, CC-0 Public Domain

PLOS ONE Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis
March 4, 2021 Adam Booth, Angus Bruno Reed, Sonia Ponzo, Arrash Yassaee, Mert Aral, David Plans, Alain Labrique, Diwakar Mohan

Aim: COVID-19 clinical presentation is heterogeneous, ranging from asymptomatic to severe cases. While there are a number of early…
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Fig 2. Time from enrollment to key secondary outcomes. by Balcells et al., CC BY 4.0

PLOS Medicine Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial
March 3, 2021 María Elvira Balcells, Luis Rojas, Nicole Le Corre, Constanza Martínez-Valdebenito, María Elena Ceballos, Marcela Ferrés, Mayling Chang, Cecilia Vizcaya, Sebastián Mondaca, Álvaro Huete, Ricardo Castro, Mauricio Sarmiento, Luis Villarroel, Alejandra Pizarro, Patricio Ross, Jaime Santander, Bárbara Lara, Marcela Ferrada, Sergio Vargas-Salas, Carolina Beltrán-Pavez, Ricardo Soto-Rifo, Fernando Valiente-Echeverría, Christian Caglevic, Mauricio Mahave, Carolina Selman, Raimundo Gazitúa, José Luis Briones, Franz Villarroel-Espindola, Carlos Balmaceda, Manuel A. Espinoza, Jaime Pereira, Bruno Nervi

Background: Convalescent plasma (CP), despite limited evidence on its efficacy, is being widely used as a compassionate therapy for…
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Fig 1. by Hassan et al., CC BY 4.0

PLOS ONE Impact of multiple waves of COVID-19 on healthcare networks in the United States
March 3, 2021 Emad M. Hassan, Hussam N. Mahmoud

The risk of overwhelming hospitals from multiple waves of COVID-19 is yet to be quantified. Here, we investigate the impact of different…
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Fig 1. Kaplan-Meier analysis by transplant. by Linares et al., CC BY 4.0

PLOS ONE A propensity score-matched analysis of mortality in solid organ transplant patients with COVID-19 compared to non-solid organ transplant patients
March 3, 2021 Laura Linares, Frederic Cofan, Fritz Diekmann, Sabina Herrera, María Angeles Marcos, María Angeles Castel, Marta Farrero, Jordi Colmenero, Pablo Ruiz, Gonzalo Crespo, Jaume Llopis, Carolina Garcia-Vidal, Àlex Soriano, Asunción Moreno, Marta Bodro, on behalf of Hospital Clínic COVID-19 research group

In the context of COVID-19 pandemic, we aimed to analyze the epidemiology, clinical characteristics, risk factors for mortality and impact…
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Fig 1. Timeline of COVID19 in three pandemic hospitals. by Alkurt et al., CC BY 4.0

PLOS ONE Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey
March 3, 2021 Gizem Alkurt, Ahmet Murt, Zeki Aydin, Ozge Tatli, Nihat Bugra Agaoglu, Arzu Irvem, Mehtap Aydin, Ridvan Karaali, Mustafa Gunes, Batuhan Yesilyurt, Hasan Turkez, Adil Mardinoglu, Mehmet Doganay, Filiz Basinoglu, Nurhan Seyahi, Gizem Dinler Doganay, Hamdi Levent Doganay

COVID-19 is a global threat with an increasing number of infections. Research on IgG seroprevalence among health care workers (HCWs) is…
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Fig 1. Limit of detection for the monoplex SARS CoV-2 RT-LAMP assay. by Jang et al., CC BY 4.0

PLOS ONE Development of a multiplex Loop-Mediated Isothermal Amplification (LAMP) assay for on-site diagnosis of SARS CoV-2
March 3, 2021 Woong Sik Jang, Da Hye Lim, Jung Yoon, Ahran Kim, Minsup Lim, Jeonghun Nam, Richard Yanagihara, Sook-Won Ryu, Bo Kyeung Jung, Nam-Hee Ryoo, Chae Seung Lim

A newly identified coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has spread rapidly from its…
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Fig 4. Relative demand for COVID-19 related chest imaging of in-patients and relative number of regional COVID-19 cases. by Koehler et al., CC BY 4.0

PLOS ONE Time series analysis of the demand for COVID-19 related chest imaging during the first wave of the SARS-CoV-2 pandemic: An explorative study
March 3, 2021 Daniel Koehler, Ann-Kathrin Ozga, Isabel Molwitz, Philipp May, Hanna Maria Görich, Sarah Keller, Gerhard Adam, Jin Yamamura

Objectives: The aim of this study was to investigate possible patterns of demand for chest imaging during the first wave of the SARS-CoV-2…
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Fig 3. Chronology of smell changes among COVID-positive healthcare workers relative to the day of positive test. by Weiss et al., CC BY 4.0

PLOS ONE Tracking smell loss to identify healthcare workers with SARS-CoV-2 infection
March 3, 2021 Julian J. Weiss, Tuki N. Attuquayefio, Elizabeth B. White, Fangyong Li, Rachel S. Herz, Theresa L. White, Melissa Campbell, Bertie Geng, Rupak Datta, Anne L. Wyllie, Nathan D. Grubaugh, Arnau Casanovas-Massana, M. Catherine Muenker, Adam J. Moore, Ryan Handoko, Akiko Iwasaki, Richard A. Martinello, Albert I. Ko, Dana M. Small, Shelli F. Farhadian, the Yale IMPACT Research Team

Introduction: Healthcare workers (HCW) treating COVID-19 patients are at high risk for infection and may also spread infection through…
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Fig 2. Crystal structure of the SR31-RBD complex. by Yao et al., CC BY 4.0

PLOS Pathogens A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2
March 3, 2021 Hebang Yao, Hongmin Cai, Tingting Li, Bingjie Zhou, Wenming Qin, Dimitri Lavillette, Dianfan Li

A key step to the SARS-CoV-2 infection is the attachment of its Spike receptor-binding domain (S RBD) to the host receptor ACE2.…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers associated with lower risk of COVID-19 in household contacts
March 2, 2021 Katrina Armstrong, Alex Soltoff, Meghan Rieu-Werden, Joshua Metlay, Jennifer Haas

Background: Use of angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) has been hypothesized to affect…
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Fig 4. The mean time to reach a detectable viral load at the infection site. by Czuppon et al., CC BY 4.0

PLOS Computational Biology Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action
March 1, 2021 Peter Czuppon, Florence Débarre, Antonio Gonçalves, Olivier Tenaillon, Alan S. Perelson, Jérémie Guedj, François Blanquart

Repurposed drugs that are safe and immediately available constitute a first line of defense against new viral infections. Despite limited…
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Fig 1. β2-m levels in Covid-19 on admission to the hospital. by Conca et al., CC BY 4.0

PLOS ONE Serum β₂-microglobulin levels in Coronavirus disease 2019 (Covid-19): Another prognosticator of disease severity?
March 1, 2021 Walter Conca, Mayyadah Alabdely, Faisal Albaiz, Michael Warren Foster, Maha Alamri, Morad Alkaff, Futwan Al-Mohanna, Nicolaas Nagelkerke, Reem Saad Almaghrabi

β2-microglobulin (β2-m), a 11.8 kDa protein, pairs non-covalently with the α3 domain of the major histocompatibility class (MHC) I α-chain…
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Fig 1. Practices of clients towards COVID-19 prevention measures in Dessie town public health facilities, Ethiopia, 2020 (n = 81). by Dewau et al., CC BY 4.0

PLOS ONE Knowledge and practice of clients on preventive measures of COVID-19 pandemic among governmental health facilities in South Wollo, Ethiopia: A facility-based cross-sectional study
March 1, 2021 Reta Dewau, Tefera Chane Mekonnen, Sisay Eshete Tadesse, Amare Muche, Getahun Gebre Bogale, Erkihun Tadesse Amsalu

Introduction: Coronavirus-19 is a global health challenge and need an immediate action. Thus, understanding client’s knowledge about…
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Fig 2. Spatial representation of data on outcome and key predictor variables (reprinted from https://tapiquen-sig.jimdofree.com/descargas-gratuitas/mundo/, under a CC BY license, with permission from Carlos Efrain Porto Tapiquen, 2021). by Amadu et al., CC BY 4.0

PLOS ONE Assessing sub-regional-specific strengths of healthcare systems associated with COVID-19 prevalence, deaths and recoveries in Africa
March 1, 2021 Iddrisu Amadu, Bright Opoku Ahinkorah, Abdul-Rahaman Afitiri, Abdul-Aziz Seidu, Edward Kwabena Ameyaw, John Elvis Hagan Jr, Eric Duku, Simon Appah Aram

Introduction: The coronavirus 2019 (COVID-19) has overwhelmed the health systems of several countries, particularly those within the…
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Fig 5. Conceptual figure on how a discrepancy between the test validation and serosurvey data can be detected. by Bouman et al., CC BY 4.0

PLOS Computational Biology Estimating the cumulative incidence of SARS-CoV-2 with imperfect serological tests: Exploiting cutoff-free approaches
February 26, 2021 Judith A. Bouman, Julien Riou, Sebastian Bonhoeffer, Roland R. Regoes

Large-scale serological testing in the population is essential to determine the true extent of the current SARS-CoV-2 pandemic.…
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Fig 2. Cumulative incidence plot for a composite outcome of invasive ventilatory support and mortality. by Efros et al., CC BY 4.0

PLOS ONE Myocardial injury in hospitalized patients with COVID-19 infection—Risk factors and outcomes
February 26, 2021 Orly Efros, Noam Barda, Eshcar Meisel, Avshalom Leibowitz, Alexander Fardman, Galia Rahav, Robert Klempfner, Ehud Grossman

Myocardial injury in hospitalized patients is associated with poor prognosis. This study aimed to evaluate risk factors for myocardial…
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Fig 1. by Mulu et al., CC BY 4.0

PLOS ONE Evaluation of sample pooling for screening of SARS CoV-2
February 26, 2021 Andargachew Mulu, Dawit Hailu Alemayehu, Fekadu Alemu, Dessalegn Abeje Tefera, Sinknesh Wolde, Gebeyehu Aseffa, Tamrayehu Seyoum, Meseret Habtamu, Alemseged Abdissa, Abebe Genetu Bayih, Getachew Tesfaye Beyene

Background: The coronavirus disease 2019 (COVID-19) pandemic has revealed the global public health importance of robust diagnostic testing.…
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Fig 2. Plasmablast-derived IgG monoclonal antibodies from three COVID-19 patients. by Huang et al., CC BY 4.0

PLOS Pathogens Breadth and function of antibody response to acute SARS-CoV-2 infection in humans
February 26, 2021 Kuan-Ying A. Huang, Tiong Kit Tan, Ting-Hua Chen, Chung-Guei Huang, Ruth Harvey, Saira Hussain, Cheng-Pin Chen, Adam Harding, Javier Gilbert-Jaramillo, Xu Liu, Michael Knight, Lisa Schimanski, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Jia-Tsrong Jan, Che Ma, William James, Rodney S. Daniels, John W. McCauley, Pramila Rijal, Alain R. Townsend

Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) have been analysed in three COVID-19…
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Fig 1. Experimental timeline. by Braun et al., CC BY 4.0

PLOS Pathogens Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck
February 26, 2021 Katarina M. Braun, Gage K. Moreno, Peter J. Halfmann, Emma B. Hodcroft, David A. Baker, Emma C. Boehm, Andrea M. Weiler, Amelia K. Haj, Masato Hatta, Shiho Chiba, Tadashi Maemura, Yoshihiro Kawaoka, Katia Koelle, David H. O’Connor, Thomas C. Friedrich

The evolutionary mechanisms by which SARS-CoV-2 viruses adapt to mammalian hosts and, potentially, undergo antigenic evolution depend on…
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Fig 6. Daily number of retweets vs. regional daily infected time courses and wavelet analysis. by Rivieccio et al., CC BY 4.0

PLOS ONE CoViD-19, learning from the past: A wavelet and cross-correlation analysis of the epidemic dynamics looking to emergency calls and Twitter trends in Italian Lombardy region
February 25, 2021 Bruno Alessandro Rivieccio, Alessandra Micheletti, Manuel Maffeo, Matteo Zignani, Alessandro Comunian, Federica Nicolussi, Silvia Salini, Giancarlo Manzi, Francesco Auxilia, Mauro Giudici, Giovanni Naldi, Sabrina Gaito, Silvana Castaldi, Elia Biganzoli

The first case of Coronavirus Disease 2019 in Italy was detected on February the 20th in Lombardy region. Since that date, Lombardy has…
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Fig 1. Results of Ewing’s autonomic battery. by Townsend et al., CC BY 4.0

PLOS ONE Fatigue following COVID-19 infection is not associated with autonomic dysfunction
February 25, 2021 Liam Townsend, David Moloney, Ciaran Finucane, Kevin McCarthy, Colm Bergin, Ciaran Bannan, Rose-Anne Kenny

Background: The long-term clinical and physiological consequences of COVID-19 infection remain unclear. While fatigue has emerged as a…
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Fig 2. The association between participants’ occupations, type of dwelling and SARS-CoV-2 seroprevalence. by Shaw et al., CC BY 4.0

PLOS ONE Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa
February 25, 2021 Jane Alexandra Shaw, Maynard Meiring, Tracy Cummins, Novel N. Chegou, Conita Claassen, Nelita Du Plessis, Marika Flinn, Andriette Hiemstra, Léanie Kleynhans, Vinzeigh Leukes, Andre G. Loxton, Candice MacDonald, Nosipho Mtala, Helmuth Reuter, Donald Simon, Kim Stanley, Gerard Tromp, Wolfgang Preiser, Stephanus T. Malherbe, Gerhard Walzl

Background: Inequality is rife throughout South Africa. The first wave of COVID-19 may have affected people in lower socioeconomic groups…
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Fig 1. The 102 Chinese cities selected in the study. by Chong et al., CC BY 4.0

PLOS Neglected Tropical Diseases Limited role for meteorological factors on the variability in COVID-19 incidence: A retrospective study of 102 Chinese cities
February 24, 2021 Ka Chun Chong, Jinjun Ran, Steven Yuk Fai Lau, William Bernard Goggins, Shi Zhao, Pin Wang, Linwei Tian, Maggie Haitian Wang, Kirran N. Mohammad, Lai Wei, Xi Xiong, Hengyan Liu, Paul Kay Sheung Chan, Huwen Wang, Yawen Wang, Jingxuan Wang

While many studies have focused on identifying the association between meteorological factors and the activity of COVID-19, we argue that…
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Fig 1. The four stages of the viral infection of a cell in the model. by Vafadar et al., CC BY 4.0

PLOS ONE Competitive exclusion during co-infection as a strategy to prevent the spread of a virus: A computational perspective
February 24, 2021 Safar Vafadar, Maryam Shahdoust, Ata Kalirad, Pooya Zakeri, Mehdi Sadeghi

Inspired by the competition exclusion principle, this work aims at providing a computational framework to explore the theoretical…
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Fig 1. by Pagani et al., CC BY 4.0

PLOS ONE Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation: Mass seroepidemiological screening in Castiglione d’Adda, Italy
February 24, 2021 Gabriele Pagani, Andrea Giacomelli, Federico Conti, Dario Bernacchia, Rossana Rondanin, Andrea Prina, Vittore Scolari, Arianna Rizzo, Martina Beltrami, Camilla Caimi, Cecilia Eugenia Gandolfi, Silvana Castaldi, Bruno Alessandro Rivieccio, Giacomo Buonanno, Giuseppe Marano, Cosimo Ottomano, Patrizia Boracchi, Elia Biganzoli, Massimo Galli

Castiglione D’Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome…
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Fig 1. Displaceable probe LAMP to detect SARS-CoV-2. by Yaren et al., CC BY 4.0

PLOS ONE Ultra-rapid detection of SARS-CoV-2 in public workspace environments
February 24, 2021 Ozlem Yaren, Jacquelyn McCarter, Nikhil Phadke, Kevin M. Bradley, Benjamin Overton, Zunyi Yang, Shatakshi Ranade, Kunal Patil, Rishikesh Bangale, Steven A. Benner

Managing the pandemic caused by SARS-CoV-2 requires new capabilities in testing, including the possibility of identifying, in minutes,…
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Fig 2. Imbalance data handling process. by Osman et al., CC BY 4.0

PLOS ONE SOM-LWL method for identification of COVID-19 on chest X-rays
February 24, 2021 Ahmed Hamza Osman, Hani Moetque Aljahdali, Sultan Menwer Altarrazi, Ali Ahmed

The outbreak of coronavirus disease 2019 (COVID-19) has had an immense impact on world health and daily life in many countries. Sturdy…
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Fig 1. Cumulative incidence plot displaying probability of discharge, AKI, and death for individuals in the top and bottom 50^th percentile of viral load. by Paranjpe et al., CC BY 4.0

PLOS ONE Association of SARS-CoV-2 viral load at admission with in-hospital acute kidney injury: A retrospective cohort study
February 24, 2021 Ishan Paranjpe, Kumardeep Chaudhary, Kipp W. Johnson, Suraj K. Jaladanki, Shan Zhao, Jessica K. De Freitas, Elisabet Pujdas, Fayzan Chaudhry, Erwin P. Bottinger, Matthew A. Levin, Zahi A. Fayad, Alexander W. Charney, Jane Houldsworth, Carlos Cordon-Cardo, Benjamin S. Glicksberg, Girish N. Nadkarni

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated Coronavirus Disease 2019 (COVID-19) is a public…
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Fig 2. Expression of ACE2 is higher and TMPRSS2 is lower in preterm lungs compared to full-term and adult lungs. by Soni et al., CC BY 4.0

PLOS ONE Comparative analysis of ACE2 protein expression in rodent, non-human primate, and human respiratory tract at baseline and after injury: A conundrum for COVID-19 pathogenesis
February 24, 2021 Sourabh Soni, Yujie Jiang, Yohannes Tesfaigzi, Jason L. Hornick, Sule Çataltepe

Angiotensin converting enzyme 2 (ACE2) is the putative functional receptor for severe acute respiratory syndrome coronavirus 2…
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Fig 1. by Sun et al., CC BY 4.0

PLOS ONE Saliva as a testing specimen with or without pooling for SARS-CoV-2 detection by multiplex RT-PCR test
February 23, 2021 Qing Sun, Jonathan Li, Hui Ren, Larry Pastor, Yulia Loginova, Roberta Madej, Kristopher Taylor, Joseph K. Wong, Zhao Zhang, Aiguo Zhang, Chuanyi M. Lu, Michael Y. Sha

Background: Sensitive and high throughput molecular detection assays are essential during the coronavirus disease 2019 (COVID-19) pandemic,…
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Fig 1. Flowchart of the study design. by Flieder et al., CC BY 4.0

PLOS ONE Retrospective analysis of 426 donors of a convalescent collective after mild COVID-19
February 23, 2021 Tobias Flieder, Tanja Vollmer, Benjamin Müller, Jens Dreier, Bastian Fischer, Cornelius Knabbe, Ingvild Birschmann

Background: The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has…
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Fig 1. Flow cytometry gating strategy of microparticles (MPs). by Zahran et al., CC BY 4.0

PLOS ONE Circulating microparticles and activated platelets as novel prognostic biomarkers in COVID-19; relation to cancer
February 22, 2021 Asmaa M. Zahran, Omnia El-Badawy, Wageeh A. Ali, Zainab Gaber Mahran, Essam Eldeen M. O. Mahran, Amal Rayan

Background and aim: The study aimed to determine whether the MPs levels and platelet activation are affected by the COVID-19 infection in…
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Fig 1. Cycle threshold (Ct) values of fluorogenic real-time quantitative polymerase chain reaction (RT-qPCR) assay targeting the ORF1ab and N regions of SARS-CoV-2 on days after the last exposure for 10 independent cases. by Yuan et al., CC BY 4.0

PLOS ONE SARS-CoV-2 viral shedding characteristics and potential evidence for the priority for faecal specimen testing in diagnosis
February 22, 2021 Chen Yuan, Hongling Wang, Kefeng Li, An Tang, Yaxin Dai, Bing Wu, Hui Zhang, Jiabei Chen, Jienan Liu, Wenjie Wu, Songye Gu, Hai Wang, Haodi Xu, Mingyu Wu, Menglu Yu, Yuchao Wang, Xinwei Yu, Jialu He, Shelan Liu, Yongli Zhang, Zhendong Tong, Jianbo Yan

This study aimed to identify the specimen type that has high positivity and its proper sampling time for severe acute respiratory syndrome…
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Untitled by Ristić et al., CC BY 4.0

PLOS ONE Validation of the STANDARD Q COVID-19 antigen test in Vojvodina, Serbia
February 22, 2021 Mioljub Ristić, Nataša Nikolić, Velibor Čabarkapa, Vesna Turkulov, Vladimir Petrović

Background: Since COVID-19 pandemic is a global crisis, tests with high sensitivity and specificity are crucial for the identification and…
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Fig 2. Main effect of combined treatment of AZ and HCQ on viral carriage reduction. by Hulme et al., CC BY 4.0

PLOS ONE A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19
February 19, 2021 Oliver James Hulme, Eric-Jan Wagenmakers, Per Damkier, Christopher Fugl Madelung, Hartwig Roman Siebner, Jannik Helweg-Larsen, Quentin F. Gronau, Thomas Lars Benfield, Kristoffer Hougaard Madsen

Gautret and colleagues reported the results of a non-randomised case series which examined the effects of hydroxychloroquine and…
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Fig 2. A non-adherence tree (NAT). by Edifor et al., CC BY 4.0

PLOS ONE Non-Adherence Tree Analysis (NATA)—An adherence improvement framework: A COVID-19 case study
February 19, 2021 Ernest Edem Edifor, Regina Brown, Paul Smith, Rick Kossik

Poor medication adherence is a global phenomenon that has received a significant amount of research attention yet remains largely…
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Fig 2. Timeline of key events and public health interventions across the five stages of the COVID-19 epidemic in Thailand. by Triukose et al., CC BY 4.0

PLOS ONE Effects of public health interventions on the epidemiological spread during the first wave of the COVID-19 outbreak in Thailand
February 19, 2021 Sipat Triukose, Sirin Nitinawarat, Ponlapat Satian, Anupap Somboonsavatdee, Ponlachart Chotikarn, Thunchanok Thammasanya, Nasamon Wanlapakorn, Natthinee Sudhinaraset, Pitakpol Boonyamalik, Bancha Kakhong, Yong Poovorawan

A novel infectious respiratory disease was recognized in Wuhan (Hubei Province, China) in December 2019. In February 2020, the disease was…
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Fig 2. Venn diagram of overlapping symptoms. by Ruíz-Quiñonez et al., CC BY 4.0

PLOS ONE Features of patients that died for COVID-19 in a hospital in the south of Mexico: A observational cohort study
February 19, 2021 Jesús Arturo Ruíz-Quiñonez, Crystell Guadalupe Guzmán-Priego, Germán Alberto Nolasco-Rosales, Carlos Alfonso Tovilla-Zarate, Oscar Israel Flores-Barrientos, Víctor Narváez-Osorio, Guadalupe del Carmen Baeza-Flores, Thelma Beatriz Gonzalez-Castro, Carlos Ramón López-Brito, Carlos Alberto Denis-García, Agustín Pérez-García, Isela Esther Juárez-Rojop

Background: Due to the wide spread of SARS-CoV2 around the world, the risk of death in individuals with metabolic comorbidities has…
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Fig 3. Numerical solutions for optimal control. by Gudara et al., CC BY 4.0

PLOS ONE A control theory approach to optimal pandemic mitigation
February 19, 2021 Prakhar Godara, Stephan Herminghaus, Knut M. Heidemann

In the framework of homogeneous susceptible-infected-recovered (SIR) models, we use a control theory approach to identify optimal pandemic…
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Fig 2. by Henzi et al., CC BY 4.0

PLOS ONE Probabilistic analysis of COVID-19 patients’ individual length of stay in Swiss intensive care units
February 19, 2021 Alexander Henzi, Gian-Reto Kleger, Matthias P. Hilty, Pedro D. Wendel Garcia, Johanna F. Ziegel, on behalf of RISC-19-ICU Investigators for Switzerland

Rationale: The COVID-19 pandemic induces considerable strain on intensive care unit resources. Objectives: We aim to provide early…
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Fig 2. by Hoertel et al., CC BY 4.0

PLOS ONE Observational study of haloperidol in hospitalized patients with COVID-19
February 19, 2021 Nicolas Hoertel, Marina Sánchez-Rico, Raphaël Vernet, Anne-Sophie Jannot, Antoine Neuraz, Carlos Blanco, Cédric Lemogne, Guillaume Airagnes, Nicolas Paris, Christel Daniel, Alexandre Gramfort, Guillaume Lemaitre, Mélodie Bernaux, Ali Bellamine, Nathanaël Beeker, Frédéric Limosin, on behalf of the AP-HP/Universities/INSERM Covid-19 research collaboration and AP-HP Covid CDR Initiative

Background: Haloperidol, a widely used antipsychotic, has been suggested as potentially useful for patients with COVID-19 on the grounds of…
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Fig 1. Awareness of study participants towards symptoms of COVID-19, 2020. by Gebretsadik et al., CC BY 4.0

PLOS ONE Knowledge, attitude, practice towards COVID-19 pandemic and its prevalence among hospital visitors at Ataye district hospital, Northeast Ethiopia
February 19, 2021 Daniel Gebretsadik, Nuru Ahmed, Edosa Kebede, Saba Gebremicheal, Melaku Ashagrie Belete, Metadel Adane

Background: Coronavirus disease 19 (COVID-19) is currently a global health threat and public health emergency of international concern.…
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Fig 2. Funnel plots for publication bias of level of knowledge towards COVID-19 among health professionals in Ethiopia. by Lake et al., CC BY 4.0

PLOS ONE Knowledge, attitude and practice towards COVID-19 among health professionals in Ethiopia: A systematic review and meta-analysis
February 19, 2021 Eyasu Alem Lake, Birhanu Wondimeneh Demissie, Natneal Atnafu Gebeyehu, Addisu Yeshambel Wassie, Kelemu Abebe Gelaw, Gedion Asnake Azeze

Background: The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a global pandemic on 11th March, 2020. In…
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Fig 4. Vascular complications in the liver. by Spogis et al., CC BY 4.0

PLOS ONE Sonographic findings in coronavirus disease-19 associated liver damage
February 19, 2021 Jakob Spogis, Florian Hagen, Wolfgang M. Thaiss, Tatjana Hoffmann, Nisar Malek, Konstantin Nikolaou, Christoph P. Berg, Stephan Singer, Hans Bösmüller, Florian Kreth, Sascha Kaufmann

Purpose: This study was conducted to evaluate the role of liver sonography in patients with coronavirus disease 2019 (COVID-19) and…
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Fig 2. 30-days Kaplan-Meier survival curves. by Díez-Manglano et al., CC BY 4.0

PLOS ONE Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry
February 19, 2021 Jesús Díez-Manglano, Marta Nataya Solís-Marquínez, Andrea Álvarez García, Nicolás Alcalá-Rivera, Irene Maderuelo Riesco, Martín Gericó Aseguinolaza, José Luis Beato Pérez, Manuel Méndez Bailón, Ane-Elbire Labirua-Iturburu Ruiz, Miriam García Gómez, Carmen Martínez Cilleros, Paula María Pesqueira Fontan, Lucy Abella Vázquez, Julio César Blázquez Encinar, Ramon Boixeda, Ricardo Gil Sánchez, Andrés de la Peña Fernández, José Loureiro Amigo, Joaquín Escobar Sevilla, Marcos Guzmán Garcia, María Dolores Martín Escalante, Jeffrey Oskar Magallanes Gamboa, Ángel Luis Martínez González, Carlos Lumbreras Bermejo, Juan Miguel Antón Santos, for the SEMI-COVID-19 Network

Aim: To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers…
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Fig 3. Kaplan Meier analysis of changes in clinical stages defined by Siddiqi et al. for the primary endpoint and secondary endpoint. by Salbach et al., CC BY 4.0

PLOS ONE Validation of two severity scores as predictors for outcome in Coronavirus Disease 2019 (COVID-19)
February 19, 2021 Christian Salbach, Matthias Mueller-Hennessen, Moritz Biener, Kiril M. Stoyanov, Mehrshad Vafaie, Michael R. Preusch, Lars P. Kihm, Uta Merle, Paul Schnitzler, Hugo A. Katus, Evangelos Giannitsis

Background: An established objective and standardized reporting of clinical severity and disease progression in COVID-19 is still not…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS Pathogens Preexisting and inducible endotoxemia as crucial contributors to the severity of COVID-19 outcomes
February 18, 2021 Ilja L. Kruglikov, Philipp E. Scherer

…
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Fig 1. SARS-CoV-2 entry mechanisms. by Murgolo et al., CC BY 4.0

PLOS Pathogens SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development
February 17, 2021 Nicholas Murgolo, Alex G. Therien, Bonnie Howell, Daniel Klein, Kenneth Koeplinger, Linda A. Lieberman, Gregory C. Adam, Jessica Flynn, Philip McKenna, Gokul Swaminathan, Daria J. Hazuda, David B. Olsen

Since the initial report of the novel Coronavirus Disease 2019 (COVID-19) emanating from Wuhan, China, Severe Acute Respiratory Syndrome…
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Fig 1. The first regression of log of confirmed cases vs consecutive days for 4 of the total of 50 countries is shown. by Kaplin et al., CC BY 4.0

PLOS ONE Evidence and magnitude of the effects of meteorological changes on SARS-CoV-2 transmission
February 17, 2021 Adam Kaplin, Caesar Junker, Anupama Kumar, Mary Anne Ribeiro, Eileen Yu, Michael Wang, Ted Smith, Shesh N. Rai, Aruni Bhatnagar

Importance: Intensity and duration of the COVID-19 pandemic, and planning required to balance concerns of saving lives and avoiding…
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Fig 2. Under-counting of deaths per age groups. by Beatriz Seoane, CC BY 4.0

PLOS ONE A scaling approach to estimate the age-dependent COVID-19 infection fatality ratio from incomplete data
February 17, 2021 Beatriz Seoane

SARS-CoV-2 has disrupted the life of billions of people around the world since the first outbreak was officially declared in China at the…
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Fig 3. Predictions for COVID-19 cases, hospitalizations, and deaths in Ijuí, Brazil. by Heck et al., CC BY 4.0

PLOS ONE Insufficient social distancing may contribute to COVID-19 outbreak: The case of Ijuí city in Brazil
February 17, 2021 Thiago Gomes Heck, Rafael Z. Frantz, Matias Nunes Frizzo, Carlos Henrique Ramires François, Mirna Stela Ludwig, Marilia Arndt Mesenburg, Giovano Pereira Buratti, Lígia Beatriz Bento Franz, Evelise Moraes Berlezi

The coronavirus disease that emerged in 2019 (COVID-19) is highly contagious and has given way to a global pandemic. A present COVID-19…
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Fig 2. Determination of IC₅₀. by Morokutti-Kurz, CC BY 4.0

PLOS ONE Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro
February 17, 2021 Martina Morokutti-Kurz, Maria Fröba, Philipp Graf, Maximilian Große, Andreas Grassauer, Janina Auth, Ulrich Schubert, Eva Prieschl-Grassauer

In the absence of a vaccine and other effective prophylactic or therapeutic countermeasures the severe acute respiratory syndrome-related…
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Fig 2. Observed and projected numbers of in-patient beds needed, ICU beds needed and cumulative number of deaths in Denmark. by Valentin et al., CC BY 4.0

PLOS ONE The basic reproduction number can be accurately estimated within 14 days after societal lockdown: The early stage of the COVID-19 epidemic in Denmark
February 16, 2021 Jan Brink Valentin, Henrik Møller, Søren Paaske Johnsen

Objective: Early identification of the basic reproduction number (BRN) is imperative to political decision making during an epidemic. In…
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Fig 5. Begg’s funnel plot for publication bias. by Fathi et al., CC BY 4.0

PLOS ONE The prognostic value of comorbidity for the severity of COVID-19: A systematic review and meta-analysis study
February 16, 2021 Mobina Fathi, Kimia Vakili, Fatemeh Sayehmiri, Ashraf Mohamadkhani, Mohammadreza Hajiesmaeili, Mostafa Rezaei-Tavirani, Owrang Eilami
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Fig 1. by Jayanama et al., CC BY 4.0

PLOS ONE The association between body mass index and severity of Coronavirus Disease 2019 (COVID-19): A cohort study
February 16, 2021 Kulapong Jayanama, Sirawat Srichatrapimuk, Kanin Thammavaranucupt, Suppachok Kirdlarp, Supawadee Suppadungsuk, Thananya Wongsinin, Nithita Nanthatanti, Sithakom Phusanti, Dhanesh Pitidhammabhorn, Somnuek Sungkanuparph
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Fig 1. Study flow and outcomes. by Ferreira et al., CC BY 4.0

PLOS ONE Prospective observational study and serosurvey of SARS-CoV-2 infection in asymptomatic healthcare workers at a Canadian tertiary care center
February 16, 2021 Victor H. Ferreira, Andrzej Chruscinski, Vathany Kulasingam, Trevor J. Pugh, Tamara Dus, Brad Wouters, Amit Oza, Matthew Ierullo, Terrance Ku, Beata Majchrzak-Kita, Sonika T. Humar, Ilona Bahinskaya, Natalia Pinzon, Jianhua Zhang, Lawrence E. Heisler, Paul M. Krzyzanowski, Bernard Lam, Ilinca M. Lungu, Dorin Manase, Krista M. Pace, Pouria Mashouri, Michael Brudno, Michael Garrels, Tony Mazzulli, Myron Cybulsky, Atul Humar, Deepali Kumar
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Fig 1. Receiver operating characteristic curves for models with different amounts of information. by Dite et al., CC BY 4.0

PLOS ONE An integrated clinical and genetic model for predicting risk of severe COVID-19: A population-based case–control study
February 16, 2021 Gillian S. Dite, Nicholas M. Murphy, Richard Allman
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Novel Coronavirus SARS-CoV-2 National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS ONE Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study
February 16, 2021 Priyamadhaba Behera, Binod Kumar Patro, Arvind Kumar Singh, Pradnya Dilip Chandanshive, Ravikumar S. R., Somen Kumar Pradhan, Siva Santosh Kumar Pentapati, Gitanjali Batmanabane, Prasanta Raghab Mohapatra, Biswa Mohan Padhy, Shakti Kumar Bal, Sudipta Ranjan Singh, Rashmi Ranjan Mohanty
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Fig 2. Distribution of symptoms among the 447 symptomatic COVID-19 cases. by Al-Rifai et al., CC BY 4.0

PLOS ONE Epidemiological characterization of symptomatic and asymptomatic COVID-19 cases and positivity in subsequent RT-PCR tests in the United Arab Emirates
February 12, 2021 Rami H. Al-Rifai, Juan Acuna, Farida Ismail Al Hossany, Bashir Aden, Shamma Abdullah Al Memari, Shereena Khamis Al Mazrouei, Luai A. Ahmed

The coronavirus disease 2019 (COVID-19) cases could be symptomatic or asymptomatic. We (1) characterized and analyzed data collected from…
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Fig 2. Comparison of sVNT results (%inhibition) between COVID-19 patients on different days after symptom onset. by Putcharoen et al., CC BY 4.0

PLOS ONE Early detection of neutralizing antibodies against SARS-CoV-2 in COVID-19 patients in Thailand
February 12, 2021 Opass Putcharoen, Supaporn Wacharapluesadee, Wan Ni Chia, Leilani Paitoonpong, Chee Wah Tan, Gompol Suwanpimolkul, Watsamon Jantarabenjakul, Chanida Ruchisrisarod, Phanni Wanthong, Jiratchaya Sophonphan, Pajaree Chariyavilaskul, Lin-Fa Wang, Thiravat Hemachudha

Background: The presence of neutralizing antibodies (NAbs) is an indicator of protective immunity for most viral infections. A newly…
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Fig 1. Household sizes and the number of positives in households of different sizes. by Dattner et al., CC BY 4.0

PLOS Computational Biology The role of children in the spread of COVID-19: Using household data from Bnei Brak, Israel, to estimate the relative susceptibility and infectivity of children
February 11, 2021 Itai Dattner, Yair Goldberg, Guy Katriel, Rami Yaari, Nurit Gal, Yoav Miron, Arnona Ziv, Rivka Sheffer, Yoram Hamo, Amit Huppert

One of the significant unanswered questions about COVID-19 epidemiology relates to the role of children in transmission. This study uses…
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Fig 3. Comparison between the synthesized distribution of time intervals between symptom onsets and confirmations (red circles) and the fitting curve (blue curve) that obeys the translational Weibull distribution (11). by Chen et al., CC BY 4.0

PLOS ONE Evaluating the effect of Chinese control measures on COVID-19 via temporal reproduction number estimation
February 11, 2021 Duanbing Chen, Tao Zhou

Control measures are necessary to contain the spread of serious infectious diseases such as COVID-19, especially in its early stage. We…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS ONE Stakeholders perspective of, and experience with contact tracing for COVID-19 in Ghana: A qualitative study among contact tracers, supervisors, and contacts
February 11, 2021 Nashira Asiimwe, Philip Teg-Nefaah Tabong, Stanley Amogu Iro, Charles Lwanga Noora, Kwabena Opoku-Mensah, Emmanuel Asampong

Background: Ghana confirmed the first two cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) infection on 12th March…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS ONE Prevalence and risk indicators of first-wave COVID-19 among oral health-care workers: A French epidemiological survey
February 11, 2021 Sébastien Jungo, Nathan Moreau, Marco E. Mazevet, Anne-Laure Ejeil, Martin Biosse Duplan, Benjamin Salmon, Violaine Smail-Faugeron

Background: Previous studies have highlighted the increased risk of contracting the COVID-19 for health-care workers and suggest that oral…
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Fig 4. Spatial pattern of COVID-19 mortality risk by sex and microregion of Brazil, 2020. by Lima et al., CC BY 4.0

PLOS ONE Spatial pattern of COVID-19 deaths and infections in small areas of Brazil
February 11, 2021 Everton Emanuel Campos de Lima, Ezra Gayawan, Emerson Augusto Baptista, Bernardo Lanza Queiroz

As of mid-August 2020, Brazil was the country with the second-highest number of cases and deaths by the COVID-19 pandemic, but with large…
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Fig 1. PRISMA flow diagram. by Chang et al., CC BY 4.0

PLOS ONE COVID-19 ICU and mechanical ventilation patient characteristics and outcomes—A systematic review and meta-analysis
February 11, 2021 Raymond Chang, Khaled Mossad Elhusseiny, Yu-Chang Yeh, Wei-Zen Sun

Background: Insight into COVID-19 intensive care unit (ICU) patient characteristics, rates and risks of invasive mechanical ventilation…
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Fig 2. Scatter plots with fitted lines of the association between the propensity score and the matched covariates (age, gender and CAN 1-year mortality score). by Osborne et al., CC BY 4.0

PLOS ONE Association of mortality and aspirin prescription for COVID-19 patients at the Veterans Health Administration
February 11, 2021 Thomas F. Osborne, Zachary P. Veigulis, David M. Arreola, Satish M. Mahajan, Eliane Röösli, Catherine M. Curtin

There is growing evidence that thrombotic and inflammatory pathways contribute to the severity of COVID-19. Common medications such as…
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Untitled by Brunaugh et al., CC BY 4.0

PLOS ONE Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae
February 11, 2021 Ashlee D. Brunaugh, Hyojong Seo, Zachary Warnken, Li Ding, Sang Heui Seo, Hugh D. C. Smyth

Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-2, the causative agent of the COVID-19 pandemic.…
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Fig 2. Latent cardiac abnormalities amongst 97 COVID-19 survivors 2–4 weeks after discharge for the index hospitalization for COVID-19. by Zhou et al., CC BY 4.0

PLOS ONE Cardiovascular sequalae in uncomplicated COVID-19 survivors
February 11, 2021 Mi Zhou, Chun-Ka Wong, Ka-Chun Un, Yuk-Ming Lau, Jeffrey Chun-Yin Lee, Frankie Chor-Cheung Tam, Yee-Man Lau, Wing-Hon Lai, Anthony Raymond Tam, Yat-Yin Lam, Polly Pang, Teresa Tong, Milky Tang, Hung-Fat Tse, Deborah Ho, Ming-Yen Ng, Esther W. Chan, Ian C. K. Wong, Chu-Pak Lau, Ivan Fan-Ngai Hung, Chung-Wah Siu

Background: A high proportion of COVID-19 patients were reported to have cardiac involvements. Data pertaining to cardiac sequalae is of…
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Fig 2. Factor associated to Covid 19 diseases. by Schönfeld et al., CC BY 4.0

PLOS ONE Clinical presentation and outcomes of the first patients with COVID-19 in Argentina: Results of 207079 cases from a national database
February 11, 2021 Daniel Schönfeld, Sergio Arias, Juan Carlos Bossio, Hugo Fernández, David Gozal, Daniel Pérez-Chada

Background: There is limited evidence on the clinical characteristics of SARS-CoV-2 infection in Latin America. We present findings from a…
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Fig 3. Monoclonal antibodies cloned from donors CoV01 and CoV02. by Mor et al., CC BY 4.0

PLOS Pathogens Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors
February 11, 2021 Michael Mor, Michal Werbner, Joel Alter, Modi Safra, Elad Chomsky, Jamie C. Lee, Smadar Hada-Neeman, Ksenia Polonsky, Cameron J. Nowell, Alex E. Clark, Anna Roitburd-Berman, Noam Ben-Shalom, Michal Navon, Dor Rafael, Hila Sharim, Evgeny Kiner, Eric R. Griffis, Jonathan M. Gershoni, Oren Kobiler, Sandra Lawrynowicz Leibel, Oren Zimhony, Aaron F. Carlin, Gur Yaari, Moshe Dessau, Meital Gal-Tanamy, David Hagin, Ben A. Croker, Natalia T. Freund

The interactions between antibodies, SARS-CoV-2 and immune cells contribute to the pathogenesis of COVID-19 and protective immunity. To…
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Fig 1. Mean minutes per day spent at 5 different behavioral risk levels, grouped by activity/copresence/location combinations: UK population pre- first lockdown, mid- first lockdown and following lockdown. by Gershuny et al., CC BY 4.0

PLOS ONE A new perspective from time use research on the effects of social restrictions on COVID-19 behavioral infection risk
February 10, 2021 Jonathan Gershuny, Oriel Sullivan, Almudena Sevilla, Marga Vega-Rapun, Francesca Foliano, Juana Lamote de Grignon, Teresa Harms, Pierre Walthery

We present findings from three waves of a population-representative, UK time-use diary survey conducted both pre- and in real time during…
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Fig 4. by Bish et al., CC BY 4.0

PLOS ONE A robust pooled testing approach to expand COVID-19 screening capacity
February 8, 2021 Douglas R. Bish, Ebru K. Bish, Hussein El-Hajj, Hrayer Aprahamian

Limited testing capacity for COVID-19 has hampered the pandemic response. Pooling is a testing method wherein samples from specimens…
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Fig 2. Kaplan-Meier survival curves. by Casas-Aparicio et al., CC BY 4.0

PLOS ONE Acute kidney injury in patients with severe COVID-19 in Mexico
February 8, 2021 Gustavo A. Casas-Aparicio, Isabel León-Rodríguez, Claudia Alvarado-de la Barrera, Mauricio González-Navarro, Amy B. Peralta-Prado, Yara Luna-Villalobos, Alejandro Velasco-Morales, Natalia Calderón-Dávila, Christopher E. Ormsby, Santiago Ávila-Ríos

Introduction: Some patients with COVID-19 pneumonia present systemic disease involving multiple systems. There is limited information about…
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Fig 1. Confirmed and probable COVID-19 cases for the state of Michigan from March 1, 2020 to July 29, 2020. by Wu et al., CC BY 4.0

PLOS ONE Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents
February 8, 2021 Kuan-Han H. Wu, Whitney E. Hornsby, Bethany Klunder, Amelia Krause, Anisa Driscoll, John Kulka, Ryan Bickett-Hickok, Austin Fellows, Sarah Graham, Erin O. Kaleba, Salim S. Hayek, Xu Shi, Nadia R. Sutton, Nicholas Douville, Bhramar Mukherjee, Kenneth Jamerson, Chad M. Brummett, Cristen J. Willer

COVID-19 has had a substantial impact on clinical care and lifestyles globally. The State of Michigan reports over 80,000 positive…
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Fig 4. ROC curves of MR-proADM, PCT, CRP, NT-proBNP, LDH and D-dimer and their comparison for predicting mortality. by Montrucchio et al., CC BY 4.0

PLOS ONE Effectiveness of mid-regional pro-adrenomedullin (MR-proADM) as prognostic marker in COVID-19 critically ill patients: An observational prospective study
February 8, 2021 Giorgia Montrucchio, Gabriele Sales, Francesca Rumbolo, Filippo Palmesino, Vito Fanelli, Rosario Urbino, Claudia Filippini, Giulio Mengozzi, Luca Brazzi

Objective: To test the effectiveness of mid-regional pro-adrenomedullin (MR-proADM) in comparison to C-reactive protein (CRP),…
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Fig 1. Undocumented COVID-19 cases. by Noh et al., CC BY 4.0

PLOS ONE Estimation of the fraction of COVID-19 infected people in U.S. states and countries worldwide
February 8, 2021 Jungsik Noh, Gaudenz Danuser

Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, daily counts of confirmed cases and deaths have been publicly…
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Fig 2. PaCO₂ correlation with the microcirculatory flow index (MFI), the perfused vessel density (PVD) and the De Backer score (DBS). by Abou-Arab et al., CC BY 4.0

PLOS ONE Microvascular flow alterations in critically ill COVID-19 patients: A prospective study
February 8, 2021 Osama Abou-Arab, Christophe Beyls, Abdelilah Khalipha, Mathieu Guilbart, Pierre Huette, Stéphanie Malaquin, Benoit Lecat, Pierre-Yves Macq, Pierre Alexandre Roger, Guillaume Haye, Michaël Bernasinski, Patricia Besserve, Sandrine Soriot-Thomas, Vincent Jounieaux, Hervé Dupont, Yazine Mahjoub

Background: Data on microcirculatory pattern of COVID-19 critically ill patients are scarce. The objective was to compare sublingual…
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Fig 1. MoCA, MMSE and HRSD total scores. by Alemanno et al., CC BY 4.0

PLOS ONE COVID-19 cognitive deficits after respiratory assistance in the subacute phase: A COVID-rehabilitation unit experience
February 8, 2021 Federica Alemanno, Elise Houdayer, Anna Parma, Alfio Spina, Alessandra Del Forno, Alessandra Scatolini, Sara Angelone, Luigia Brugliera, Andrea Tettamanti, Luigi Beretta, Sandro Iannaccone

Introduction: COVID-19 complications can include neurological, psychiatric, psychological, and psychosocial impairments. Little is known on…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests
February 8, 2021 Mitsuru Wakita, Mayumi Idei, Kaori Saito, Yuki Horiuchi, Kotoko Yamatani, Suzuka Ishikawa, Takamasa Yamamoto, Gene Igawa, Masanobu Hinata, Katsuhiko Kadota, Taro Kurosawa, Sho Takahashi, Takumi Saito, Shigeki Misawa, Chihiro Akazawa, Toshio Naito, Takashi Miida, Kazuhisa Takahashi, Tomohiko Ai, Yoko Tabe

We examined the usefulness of five COVID-19 antibody detection tests using 114 serum samples at various time points from 34 Japanese…
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Fig 2. Dendrogram and heatmap of the drug-disease network. by Fiscon et al., CC BY 4.0

PLOS Computational Biology SAveRUNNER: A network-based algorithm for drug repurposing and its application to COVID-19
February 5, 2021 Giulia Fiscon, Federica Conte, Lorenzo Farina, Paola Paci

The novelty of new human coronavirus COVID-19/SARS-CoV-2 and the lack of effective drugs and vaccines gave rise to a wide variety of…
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Fig 1. by Workman et al., CC BY 4.0

PLOS ONE Airborne aerosol olfactory deposition contributes to anosmia in COVID-19
February 5, 2021 Alan D. Workman, Aria Jafari, Roy Xiao, Benjamin S. Bleier

Introduction: Olfactory dysfunction (OD) affects a majority of COVID-19 patients, is atypical in duration and recovery, and is associated…
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Fig 1. Temporal changes in laboratory markers from illness onset in patients hospitalized with COVID-19. by Kantri et al., CC BY 4.0

PLOS ONE Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco
February 4, 2021 Aziza Kantri, Jihane Ziati, Mohamed Khalis, Amal Haoudar, Karim El Aidaoui, Youssef Daoudi, Inas Chikhaoui, Khalid El Yamani, Mohammed Mouhaoui, Jalila El Bakkouri, Nezha Dini, Mohammed Mahi, Abdelhamid Naitlho, Abdelkrim Bahlaoui, Ahmed Bennana, Mustapha Noussair, Lahcen Belyamani, Chafik El Kettani

Since December 2019, the coronavirus disease (COVID-19) pandemic has catapulted the world into a marked health crisis, with over 29…
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Fig 4. Large-scale molecular screening of SARS-CoV-2 with swab pooling. by Christoff et al., CC BY 4.0

PLOS ONE Swab pooling: A new method for large-scale RT-qPCR screening of SARS-CoV-2 avoiding sample dilution
February 4, 2021 Ana Paula Christoff, Giuliano Netto Flores Cruz, Aline Fernanda Rodrigues Sereia, Dellyana Rodrigues Boberg, Daniela Carolina de Bastiani, Laís Eiko Yamanaka, Gislaine Fongaro, Patrícia Hermes Stoco, Maria Luiza Bazzo, Edmundo Carlos Grisard, Camila Hernandes, Luiz Felipe Valter de Oliveira

To minimize sample dilution effect on SARS-CoV-2 pool testing, we assessed analytical and diagnostic performance of a new methodology,…
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Fig 3. Dynamics pre and post social distancing interventions in network-structured populations with household and external transmission. by Nande et al., CC BY 4.0

PLOS Computational Biology Dynamics of COVID-19 under social distancing measures are driven by transmission network structure
February 3, 2021 Anjalika Nande, Ben Adlam, Justin Sheen, Michael Z. Levy, Alison L. Hill

In the absence of pharmaceutical interventions, social distancing is being used worldwide to curb the spread of COVID-19. The impact of…
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Fig 3. Symptoms in the first three weeks after symptom onset for patients presenting early (≤ 7 days after symptom onset) or late (> 7 days after symptom onset). by Schneider et al., CC BY 4.0

PLOS ONE Covid-19 in outpatients—Is fever a useful indicator for SARS-CoV-2 infection?
February 3, 2021 Anne Schneider, Holger Kirsten, Franziska Lordick, Florian Lordick, Christoph Lübbert, Amrei von Braun

Objective: Understanding mild to moderate symptoms of coronavirus disease 2019 (Covid-19) is important in order to identify active cases…
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Fig 2. Bar graph. by et al. Olivas-Martínez, CC BY 4.0

PLOS ONE In-hospital mortality from severe COVID-19 in a tertiary care center in Mexico City; causes of death, risk factors and the impact of hospital saturation
February 3, 2021 Antonio Olivas-Martínez, José Luis Cárdenas-Fragoso, José Víctor Jiménez, Oscar Arturo Lozano-Cruz, Edgar Ortiz-Brizuela, Víctor Hugo Tovar-Méndez, Carla Medrano-Borromeo, Alejandra Martínez-Valenzuela, Carla Marina Román-Montes, Bernardo Martínez-Guerra, María Fernanda González-Lara, Thierry Hernandez-Gilsoul, Alfonso Gulias Herrero, Karla María Tamez-Flores, Eric Ochoa-Hein, Alfredo Ponce-de-León, Arturo Galindo-Fraga, David Kershenobich-Stalnikowitz, José Sifuentes-Osornio

Background: As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has remained in Latin America, Mexico has become…
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Fig 1. USDA 2013 metro and non-metro South Carolina county designations. by Huang et al., CC BY 4.0

PLOS ONE Urban-rural differences in COVID-19 exposures and outcomes in the South: A preliminary analysis of South Carolina
February 3, 2021 Qian Huang, Sarah Jackson, Sahar Derakhshan, Logan Lee, Erika Pham, Amber Jackson, Susan L. Cutter

As the COVID-19 pandemic moved beyond the initial heavily impacted and urbanized Northeast region of the United States, hotspots of cases…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC0 Public Domain

PLOS Neglected Tropical Diseases China’s COVID-19 response for the protection of rural communities
February 2, 2021 Yaxin Zhu, Shenglin Zhao, Bo Qu

…
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Novel Coronavirus SARS-CoV-2 NIAID/NIH, CC-0

PLOS ONE Machine learning model for predicting severity prognosis in patients infected with COVID-19: Study protocol from COVID-AI Brasil
February 1, 2021 Flávia Paiva Proença Lobo Lopes, Felipe Campos Kitamura, Gustavo Faibischew Prado, Paulo Eduardo de Aguiar Kuriki, Marcio Ricardo Taveira Garcia, COVID-AI-Brasil

The new coronavirus, which began to be called SARS-CoV-2, is a single-stranded RNA beta coronavirus, initially identified in Wuhan (Hubei…
PLOS ONE A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease
February 1, 2021 Jeremy D. Baker, Rikki L. Uhrich, Gerald C. Kraemer, Jason E. Love, Brian C. Kraemer

Effective SARS-CoV-2 antiviral drugs are desperately needed. The SARS-CoV-2 main protease (Mpro) appears as an attractive target for drug…
PLOS Pathogens Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab
February 1, 2021 Gaia Meoni, Veronica Ghini, Laura Maggi, Alessia Vignoli, Alessio Mazzoni, Lorenzo Salvati, Manuela Capone, Anna Vanni, Leonardo Tenori, Paolo Fontanari, Federico Lavorini, Adriano Peris, Alessandro Bartoloni, Francesco Liotta, Lorenzo Cosmi, Claudio Luchinat, Francesco Annunziato, Paola Turano

The current pandemic emergence of novel coronavirus disease (COVID-19) poses a relevant threat to global health. SARS-CoV-2 infection is…
PLOS Computational Biology Assessing the potential impact of transmission during prolonged viral shedding on the effect of lockdown relaxation on COVID-19
January 29, 2021 Burcu Tepekule, Anthony Hauser, Viacheslav N. Kachalov, Sara Andresen, Thomas Scheier, Peter W. Schreiber, Huldrych F. Günthard, Roger D. Kouyos

A key parameter in epidemiological modeling which characterizes the spread of an infectious disease is the generation time, or more…
PLOS ONE Early risk markers for severe clinical course and fatal outcome in German patients with COVID-19
January 29, 2021 Paul Balfanz, Bojan Hartmann, Dirk Müller-Wieland, Michael Kleines, Dennis Häckl, Nils Kossack, Alexander Kersten, Christian Cornelissen, Tobias Müller, Ayham Daher, Robert Stöhr, Johannes Bickenbach, Gernot Marx, Nikolaus Marx, Michael Dreher

Background: Some patients with Corona Virus Disease 2019 (COVID-19) develop a severe clinical course with acute respiratory distress…
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NIAID/NIH

PLOS ONE High SARS-CoV-2 load in the nasopharynx of patients with a mild form of COVID-19 is associated with clinical deterioration regardless of the hydroxychloroquine administration
January 29, 2021 Alexey Komissarov, Ivan Molodtsov, Oxana Ivanova, Elena Maryukhnich, Svetlana Kudryavtseva, Alexey Mazus, Evgeniy Nikonov, Elena Vasilieva

Because of the constantly growing numbers of COVID-19 infections and deaths, attempts were undertaken to find drugs with anti-SARS-CoV-2…
PLOS ONE The differential impact of pediatric COVID-19 between high-income countries and low- and middle-income countries: A systematic review of fatality and ICU admission in children worldwide
January 29, 2021 Taito Kitano, Mao Kitano, Carsten Krueger, Hassan Jamal, Hatem Al Rawahi, Rachelle Lee-Krueger, Rose Doulin Sun, Sandra Isabel, Marta Taida García-Ascaso, Hiromi Hibino, Bettina Camara, Marc Isabel, Leanna Cho, Helen E. Groves, Pierre-Philippe Piché-Renaud, Michael Kossov, Ikuho Kou, Ilsu Jon, Ana C. Blanchard, Nao Matsuda, Quenby Mahood, Anupma Wadhwa, Ari Bitnun, Shaun K. Morris

Background: The overall global impact of COVID-19 in children and regional variability in pediatric outcomes are presently unknown.…
PLOS ONE Effect of timing of implementation of containment measures on Covid-19 epidemic. The case of the first wave in Italy
January 29, 2021 Laura Timelli, Enrico Girardi

There is evidence that adoption of non-pharmaceutical containment measures (NPMs) may have had a major impact on Covid-19 epidemic…
PLOS ONE Evaluation of the practicability of a finger-stick whole-blood SARS-Cov-2 self-test adapted for the general population
January 28, 2021 Thierry Prazuck, Jean Phan Van, Florence Sinturel, Frederique Levray, Allan Elie, Denise Camera, Gilles Pialoux

Background: COVID-19 (COronaVIrus Disease 2019) is an infectious respiratory disease caused by the novel SARS-CoV-2 virus. Point of Care…
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NIAID/NIH

PLOS ONE High-dose corticosteroid pulse therapy increases the survival rate in COVID-19 patients at risk of hyper-inflammatory response
January 28, 2021 Miguel Ángel López Zúñiga, Aida Moreno-Moral, Ana Ocaña-Granados, Francisco Andrés Padilla-Moreno, Alba María Castillo-Fernández, Dionisio Guillamón-Fernández, Carolina Ramírez-Sánchez, María Sanchez-Palop, Justo Martínez-Colmenero, María Amparo Pimentel-Villar, Sara Blázquez-Roselló, José Juan Moreno-Sánchez, María López-Vílchez, Inmaculada Prior-Sánchez, Rosario Jódar-Moreno, Miguel Ángel López Ruz

Objective: Test whether high dose corticosteroid pulse therapy (HDCPT) with either methylprednisolone or dexamethasone is associated with…
PLOS ONE Epidemiology of COVID-19 vs. influenza: Differential failure of COVID-19 mitigation among Hispanics, Cook County Health, Illinois
January 28, 2021 William E. Trick, Sheila Badri, Kruti Doshi, Huiyuan Zhang, Katayoun Rezai, Michael J. Hoffman, Robert A. Weinstein

Background: During the early phases of the COVID-19 pandemic in the U.S., African-American or Hispanic communities were disproportionately…
PLOS ONE SARS-CoV-2 infection in asymptomatic healthcare workers at a clinic in Chile
January 28, 2021 Claudio Olmos, Gonzalo Campaña, Victor Monreal, Paola Pidal, Nannet Sanchez, Constanza Airola, Dayan Sanhueza, Patricio Tapia, Ana María Muñoz, Felipe Corvalan, Sebastian Hurtado, Claudio Meneses, Ariel Orellana, Martin Montecino, Gloria Arriagada, Fernando Jose Bustos

Asymptomatic SARS-CoV-2 infection of healthcare workers (HCWs) has been reported as a key player in the nosocomial spreading of COVID-19.…
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NIAID/NIH

PLOS ONE Risk factors for mortality of coronavirus disease-2019 (COVID-19) patients in two centers of Hubei province, China: A retrospective analysis
January 28, 2021 Xiao-Bin Zhang, Lan Hu, Quan Ming, Xiao-Jie Wei, Zhen-Yu Zhang, Li-Da Chen, Ming-Hui Wang, Weng-Zhen Yao, Qiu-Fen Huang, Zhang-Qiang Ye, Yu-Qing Cai, Hui-Qing Zeng

Purpose: Since the outbreak in late December 2019 in Wuhan, China, coronavirus disease-2019 (COVID-19) has become a global pandemic. We…
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Image by Silas Camargo Silão from Pixabay

PLOS ONE Factors associated with admission to intensive care units in COVID-19 patients in Lyon-France
January 27, 2021 Philippe Vanhems, Marie-Paule Gustin, Christelle Elias, Laetitia Henaff, Cédric Dananché, Béatrice Grisi, Elodie Marion, Nagham Khanafer, Delphine Hilliquin, Sophie Gardes, Solweig Gerbier-Colomban, Selilah Amour, Elisabetta Kuczewski, Vanessa Escuret, Bruno Lina, Mitra Saadatian-Elahi, On behalf of COVID-Outcomes-HCL Consortium

Introduction: A new respiratory virus, SARS-CoV-2, has emerged and spread worldwide since late 2019. This study aims at analysing clinical…
PLOS ONE First report on prevalence of SARS-CoV-2 infection among health-care workers in Nicaragua
January 27, 2021 Jorge A. Huete-Pérez, Cristiana Cabezas-Robelo, Lucía Páiz-Medina, Carlos A. Hernández-Álvarez, Carlos Quant-Durán, James H. McKerrow

The Nicaraguan COVID-19 situation is exceptional for Central America. The government restricts testing and testing supplies, and the true…
PLOS ONE Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study
January 26, 2021 Isa Murrell, Donall Forde, Wioleta Zelek, Linda Tyson, Lisa Chichester, Nicki Palmer, Rachel Jones, B. Paul Morgan, Catherine Moore

Antibody responses are important in the control of viral respiratory infection in the human host. What is not clear for SARS-CoV-2 is how…
PLOS ONE Effects of short-term travel on COVID-19 spread: A novel SEIR model and case study in Minnesota
January 22, 2021 Michael W. Levin, Mingfeng Shang, Raphael Stern

The novel coronavirus responsible for COVID-19 was first identified in Hubei Province, China in December, 2019. Within a matter of months…
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NIAID/NIH

PLOS ONE The independent factors associated with oxygen therapy in COVID-19 patients under 65 years old
January 22, 2021 Yue-Nan Ni, Ting Wang, Bin-miao Liang, Zong-An Liang

Background: The number of hospitalized young coronavirus disease 2019 (COVID-19) patients has increased significantly. However, specific…
PLOS ONE COVID-19 prevalence and predictors in United States adults during peak stay-at-home orders
January 22, 2021 Robert Morlock, Amy Morlock, Martha Downen, Sonali N. Shah

Background: Early recognition of COVID-19 cases is essential for effective public health measures aimed at isolation of individuals…
PLOS ONE Rapid conversion of an in-patient hospital unit to accommodate COVID-19: An interdisciplinary human factors, ethnography, and infection prevention and control approach
January 22, 2021 Raad Fadaak, Jan M. Davies, Marlot Johanna Blaak, John Conly, Joanne Haslock, Ashley Kenny, Nicole Pinto, Myles Leslie

Background: In response to the Coronavirus disease-19 (COVID-19) pandemic, in-patient units in hospitals around the world have altered…
PLOS ONE Incidence and characterization of acute pulmonary embolism in patients with SARS-CoV-2 pneumonia: A multicenter Italian experience
January 22, 2021 Marco Loffi, Valentina Regazzoni, Marco Toselli, Alberto Cereda, Anna Palmisano, Davide Vignale, Francesco Moroni, Gianluca Pontone, Daniele Andreini, Elisabetta Maria Mancini, Alberto Monello, Gianmarco Iannopollo, Gianni Casella, Francesco Monetti, Lorenzo Monti, Giuseppe Ferrillo, Gaetano Liccardo, Elisabetta Tonet, Ottavio Zucchetti, Alberto Cossu, Marco Dugo, Gianluigi Patelli, Pietro Sergio, Antonio Esposito, Antonio Colombo, Francesco Giannini, Raffaele Piccolo, Gian Battista Danzi

Background and aims: Several studies reported a high incidence of pulmonary embolism (PE) among patients with severe acute respiratory…
PLOS ONE Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study
January 22, 2021 Steve Goodacre, Ben Thomas, Laura Sutton, Matthew Burnsall, Ellen Lee, Mike Bradburn, Amanda Loban, Simon Waterhouse, Richard Simmonds, Katie Biggs, Carl Marincowitz, Jose Schutter, Sarah Connelly, Elena Sheldon, Jamie Hall, Emma Young, Andrew Bentley, Kirsty Challen, Chris Fitzsimmons, Tim Harris, Fiona Lecky, Andrew Lee, Ian Maconochie, Darren Walter

Objectives: We aimed to derive and validate a triage tool, based on clinical assessment alone, for predicting adverse outcome in acutely…
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National Institute of Allergy and Infectious Diseases, NIH

PLOS ONE Development and validation of a clinical risk score to predict the risk of SARS-CoV-2 infection from administrative data: A population-based cohort study from Italy
January 20, 2021 Valentina Orlando, Federico Rea, Laura Savaré, Ilaria Guarino, Sara Mucherino, Alessandro Perrella, Ugo Trama, Enrico Coscioni, Enrica Menditto, Giovanni Corrao

Background: The novel coronavirus (SARS-CoV-2) pandemic spread rapidly worldwide increasing exponentially in Italy. To date, there is lack…
PLOS ONE Characteristics and predicting factors of Corona Virus Disease-2019 (COVID-19) among healthcare providers in a developing country
January 20, 2021 Rehab H. El-Sokkary, Amani El-Kholy, Sally Mohy Eldin, Walaa Shawky Khater, Doaa Mostafa Gad, Shereen Bahgat, Essam Edin M. Negm, Jehan Ali El Kholy, Sherif Mowafy, Eman Mahmoud, Eman M. Mortada

A limited number of publications have identified risk factors for Corona Virus Disease 2019 (COVID-19) among Healthcare Providers (HCPs).…
PLOS ONE Converting the maybes: Crucial for a successful COVID-19 vaccination strategy
January 20, 2021 Katie Attwell, Joshua Lake, Joanne Sneddon, Paul Gerrans, Chris Blyth, Julie Lee

Background: Broad community acceptance of a COVID-19 vaccination will be critical for effectively halting the spread of the virus. In this…
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NIAID-RML

PLOS ONE Medical resources and coronavirus disease (COVID-19) mortality rate: Evidence and implications from Hubei province in China
January 15, 2021 Lin Xie, Hualei Yang, Xiaodong Zheng, Yuanyang Wu, Xueyu Lin, Zheng Shen

In light of the ongoing coronavirus disease (COVID-19) pandemic, this study aims to examine the relationship between the availability of…
PLOS ONE Impact of SARS-CoV-2 pandemic among health care workers in a secondary teaching hospital in Spain
January 14, 2021 Javier Garralda Fernandez, Ignacio Molero Vilches, Alfredo Bermejo Rodríguez, Isabel Cano Torres, Elda Isabel Colino Romay, Isabel García Arata, Jerónimo Jaqueti Aroca, Rosa Lillo Rodríguez, Daniel López Lacomba, Luis Mazón Cuadrado, Laura Molina Esteban, Luis Javier Morales García, Laura Moratilla Monzo, Elva Nieto-Borrajo, María Pacheco Delgado, Santiago Prieto Menchero, Cristina Sánchez Hernández, Eva Sánchez Testillano, Jesús García-Martínez

Background: The COVID-19 pandemic has posed a huge challenge to healthcare systems and their personnel worldwide. The study of the impact…
PLOS ONE High-risk chest radiographic features associated with COVID-19 disease severity
January 14, 2021 Sean Wei Xiang Ong, Terrence Chi Hong Hui, Yeong Shyan Lee, Salahudeen Mohamed Haja Mohideen, Barnaby Edward Young, Cher Heng Tan, David Chien Lye

Objectives: High-risk CXR features in COVID-19 are not clearly defined. We aimed to identify CXR features that correlate with severe…
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NIAID-RML

PLOS ONE Health conditions of potential risk for severe Covid-19 in institutionalized elderly people
January 14, 2021 Mayara Priscilla Dantas Araújo, Vilani Medeiros de Araújo Nunes, Larissa de Albuquerque Costa, Talita Araujo de Souza, Gilson de Vasconcelos Torres, Thaiza Teixeira Xavier Nobre

The objective of this study was to identify the health conditions considered potential risk factors for severe Covid-19 and analyze its…
PLOS ONE Clinical and radiological findings of adult hospitalized patients with community-acquired pneumonia from SARS-CoV-2 and endemic human coronaviruses
January 14, 2021 Moon Seong Baek, Min Jae Cha, Min-Chul Kim, Jin-Won Chung, Won-Young Kim, Hyewon Choi, Seong-Ho Choi

Endemic human coronaviruses (HCoVs) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are members of the family…
PLOS Pathogens Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina
January 14, 2021 Diego S. Ojeda, María Mora Gonzalez Lopez Ledesma, Horacio M. Pallarés, Guadalupe S. Costa Navarro, Lautaro Sanchez, Beatriz Perazzi, Sergio M. Villordo, Diego E. Alvarez, BioBanco Working Group , Marcela Echavarria, Kasopefoluwa Y. Oguntuyo, Christian S. Stevens, Benhur Lee, Jorge Carradori, Julio J. Caramelo, Marcelo J. Yanovsky, Andrea V. Gamarnik

We report the emergency development and application of a robust serologic test to evaluate acute and convalescent antibody responses to…
PLOS ONE Earliest detection to date of SARS-CoV-2 in Florida: Identification together with influenza virus on the main entry door of a university building, February 2020
January 13, 2021 John Lednicky, Marco Salemi, Kuttichantran Subramaniam, Thomas B. Waltzek, Tara Sabo-Attwood, Julia C. Loeb, Shannon Hentschel, Massimiliano S. Tagliamonte, Simone Marini, Md. Mahbubul Alam, Caroline J. Stephenson, Maha Elbadry, J. Glenn Morris Jr.

In February and March, 2020, environmental surface swab samples were collected from the handle of the main entry door of a major…
PLOS ONE Sex differences in susceptibility, severity, and outcomes of coronavirus disease 2019: Cross-sectional analysis from a diverse US metropolitan area
January 13, 2021 Farhaan S. Vahidy, Alan P. Pan, Hilda Ahnstedt, Yashasvee Munshi, Huimahn A. Choi, Yordanos Tiruneh, Khurram Nasir, Bita A. Kash, Julia D. Andrieni, Louise D. McCullough

Introduction: Sex is increasingly recognized as an important factor in the epidemiology and outcome of many diseases. This also appears to…
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NIAID-RML

PLOS ONE Impact of first wave of SARS-CoV-2 infection in patients with Systemic Lupus Erythematosus: Weighting the risk of infection and flare
January 13, 2021 Dina Zucchi, Chiara Tani, Elena Elefante, Chiara Stagnaro, Linda Carli, Viola Signorini, Francesco Ferro, Francesca Trentin, Giovanni Fulvio, Chiara Cardelli, Marco Di Battista, Gianmaria Governato, Antonio Figliomeni, Marta Mosca

Introduction: The aim of this study was to investigate the incidence and clinical presentation of SARS-CoV-2 infections in a Systemic Lupus…
PLOS ONE Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19
January 12, 2021 Shaul Lev, Tamar Gottesman, Gal Sahaf Levin, Doron Lederfein, Evgeny Berkov, Dror Diker, Aliza Zaidman, Amir Nutman, Tahel Ilan Ber, Alon Angel, Lior Kellerman, Eran Barash, Roy Navon, Olga Boico, Yael Israeli, Michal Rosenberg, Amir Gelman, Roy Kalfon, Einav Simon, Noa Avni, Mary Hainrichson, Oren Zarchin, Tanya M. Gottlieb, Kfir Oved, Eran Eden, Boaz Tadmor

Background: Treatment of severely ill COVID-19 patients requires simultaneous management of oxygenation and inflammation without…
PLOS ONE Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2)
January 8, 2021 Samuel Egieyeh, Elizabeth Egieyeh, Sarel Malan, Alan Christofells, Burtram Fielding

Drug repurposing for COVID-19 has several potential benefits including shorter development time, reduced costs and regulatory support for…
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National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH

PLOS Neglected Tropical Diseases COVID-19, leprosy, and neutrophils
January 7, 2021 Veronica Schmitz, Jéssica Brandão dos Santos

Coronavirus Disease 2019 (COVID-19), a disease caused by the betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2),…
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National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH

PLOS Computational Biology The value of decreasing the duration of the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
January 7, 2021 Bruce Y. Lee, Sarah M. Bartsch, Marie C. Ferguson, Patrick T. Wedlock, Kelly J. O’Shea, Sheryl S. Siegmund, Sarah N. Cox, James A. McKinnell

Finding medications or vaccines that may decrease the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
PLOS Neglected Tropical Diseases Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
January 7, 2021 Shuhui Duan, Meiying Zhou, Wen Zhang, Jianwei Shen, Rui Qi, Xiangrong Qin, Hao Yu, Chuanmin Zhou, Qing Hu, Xue-Jie Yu

Wuhan City (WH) in China was the first place to report COVID-19 in the world and the outbreak of COVID-19 was controlled in March of 2020…
PLOS ONE Therapeutic plasma exchange for coronavirus disease-2019 triggered cytokine release syndrome; a retrospective propensity matched control study
January 7, 2021 Sultan Mehmood Kamran, Zill-e-Humayun Mirza, Arshad Naseem, Jahanzeb Liaqat, Imran Fazal, Wasim Alamgir, Farrukh Saeed, Salman Saleem, Shazia Nisar, Muhammad Ali Yousaf, Asad Zaman Khan, Mehmood Hussain, Rizwan Azam, Maryam Hussain, Kumail Abbas Khan, Yousaf Jamal, Raheel Iftikhar

Background: Cytokine release syndrome (CRS) plays a pivotal role in the pathophysiology and progression of Coronavirus disease-2019…
PLOS ONE A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients
January 7, 2021 Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai, Vincent VanBuren

Purpose: COVID-19 pandemic has multifaceted presentations with rising evidence of immune-mediated mechanisms underplay. We sought to…
PLOS ONE Mortality and other outcomes of patients with coronavirus disease pneumonia admitted to the emergency department: A prospective observational Brazilian study
January 7, 2021 Rodrigo A. Brandão Neto, Julio F. Marchini, Lucas O. Marino, Julio C. G. Alencar, Felippe Lazar Neto, Sabrina Ribeiro, Fernando V. Salvetti, Hassan Rahhal, Luz Marina Gomez Gomez, Caue G. Bueno, Carine C. Faria, Victor P. da Cunha, Eduardo Padrão, Irineu T. Velasco, Heraldo Possolo de Souza, Emergencia USP Covid group

Background: The first cases of coronavirus disease (COVID-19) in Brazil were diagnosed in February 2020. Our Emergency Department (ED) was…
PLOS Neglected Tropical Diseases Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in China
January 6, 2021 Lu Long, Liang Wu, Lang Chen, Daixing Zhou, Hongyu Wu, Donghao Lu, Honglin Li, Xiaoxia Duan, Yutong Han, Xianzhi Li, Qiuxia Wang, Jing Zhang

Background: Until now, no antiviral treatment has been proven to be effective for the coronavirus disease 2019 (COVID-19). The timing of…
PLOS ONE Optimal periodic closure for minimizing risk in emerging disease outbreaks
January 6, 2021 Jason Hindes, Simone Bianco, Ira B. Schwartz

Without vaccines and treatments, societies must rely on non-pharmaceutical intervention strategies to control the spread of emerging…
PLOS ONE The efficacy and safety of hydroxychloroquine for COVID-19 prophylaxis: A systematic review and meta-analysis of randomized trials
January 6, 2021 Kimberley Lewis, Dipayan Chaudhuri, Fayez Alshamsi, Laiya Carayannopoulos, Karin Dearness, Zain Chagla, Waleed Alhazzani, for the GUIDE Group

Background: Populations such as healthcare workers (HCW) that are unable to practice physical distancing are at high risk of acquiring…
PLOS ONE Covert cases of Severe Acute Respiratory Syndrome Coronavirus 2: An obscure but present danger in regions endemic for Dengue and Chikungunya viruses
January 6, 2021 Lorenzzo Lyrio Stringari, Michel Norbim de Souza, Nésio Fernandes de Medeiros Junior, Jaqueline Pegoretti Goulart, Camila Giuberti, Reynaldo Dietze, Rodrigo Ribeiro-Rodrigues

Background: The impact of SARS-CoV-2 in regions endemic for both Dengue and Chikungunya is still not fully understood. Considering that…
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National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH

PLOS ONE The chronic kidney disease and acute kidney injury involvement in COVID-19 pandemic: A systematic review and meta-analysis
January 5, 2021 Ya-Fei Liu, Zhe Zhang, Xiao-Li Pan, Guo-Lan Xing, Ying Zhang, Zhang-Suo Liu, Sheng-Hao Tu

Background: Currently, the SARS-CoV-2 promptly spread across China and around the world. However, there are controversies about whether…
PLOS ONE The association of chest radiographic findings and severity scoring with clinical outcomes in patients with COVID-19 presenting to the emergency department of a tertiary care hospital in Pakistan
January 5, 2021 Raima Kaleemi, Kiran Hilal, Ainan Arshad, Russell Seth Martins, Avinash Nankani, Haq TU, Sundas Basharat, Zeeshan Ansar

Introduction: While chest x-rays (CXRs) represent a cost-effective imaging modality for developing countries like Pakistan, their utility…
PLOS ONE Propagation of viral bioaerosols indoors
January 5, 2021 Olga B. Kudryashova, Evgeny V. Muravlev, Aleksandra A. Antonnikova, Sergey S. Titov

Here we look into the spread of aerosols indoors that may potentially carry viruses. Many viruses, including the novel SARS-CoV-2, are…
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National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH

PLOS Neglected Tropical Diseases Zinc against COVID-19? Symptom surveillance and deficiency risk groups
January 4, 2021 Marcin P. Joachimiak

A wide variety of symptoms is associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and these symptoms…
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NIAID/NIH

PLOS Pathogens The role of Neuropilin-1 in COVID-19
January 4, 2021 Bindu S. Mayi, Jillian A. Leibowitz, Arden T. Woods, Katherine A. Ammon, Alphonse E. Liu, Aarti Raja

Neuropilin-1 (NRP-1), a member of a family of signaling proteins, was shown to serve as an entry factor and potentiate SARS Coronavirus 2…
PLOS ONE The role of CPAP as a potential bridge to invasive ventilation and as a ceiling-of-care for patients hospitalized with Covid-19—An observational study
December 31, 2020 Jonathan Walker, Shaman Dolly, Liji Ng, Melissa Prior-Ong, Kalpana Sabapathy

Background: Continuous positive airway pressure (CPAP) ventilation may be used as a potential bridge to invasive mechanical ventilation…
PLOS ONE The risk factors for mortality of diabetic patients with severe COVID-19: A retrospective study of 167 severe COVID-19 cases in Wuhan
December 31, 2020 Yan Hui, Yi Li, Xiwen Tong, Zhiqiong Wang, Xia Mao, Lifang Huang, Donghua Zhang

Diabetes is one of the most common comorbidities in adult patients with coronavirus disease 2019 (COVID-19). This study aimed to analyze…
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NIAID/NIH

PLOS ONE Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis
December 31, 2020 Julie Gorham, Anthony Moreau, Francis Corazza, Lorenzo Peluso, Fanny Ponthieux, Marta Talamonti, Antonio Izzi, Carole Nagant, Narcisse Ndieugnou Djangang, Alessandra Garufi, Jacques Creteur, Fabio Silvio Taccone

Introduction: Coronavirus disease 2019 (COVID-19) appeared in China in December 2019 and has spread around the world. High Interleukin-6…
PLOS ONE Spatiotemporal spread pattern of the COVID-19 cases in China
December 31, 2020 Yongjiu Feng, Qingmei Li, Xiaohua Tong, Rong Wang, Shuting Zhai, Chen Gao, Zhenkun Lei, Shurui Chen, Yilun Zhou, Jiafeng Wang, Xiongfeng Yan, Huan Xie, Peng Chen, Shijie Liu, Xiong Xv, Sicong Liu, Yanmin Jin, Chao Wang, Zhonghua Hong, Kuifeng Luan, Chao Wei, Jinfu Xu, Hua Jiang, Changjiang Xiao, Yiyou Guo

The COVID-19 pandemic is currently spreading widely around the world, causing huge threats to public safety and global society. This study…
PLOS ONE SARS-CoV-2 PCR cycle threshold at hospital admission associated with patient mortality
December 31, 2020 Jui Choudhuri, Jamal Carter, Randin Nelson, Karin Skalina, Marika Osterbur-Badhey, Andrew Johnston, Doctor Goldstein, Monika Paroder, James Szymanski

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cycle threshold (Ct) has been suggested as an approximate measure…
PLOS ONE Antibody response to SARS-CoV-2 infection in humans: A systematic review
December 31, 2020 Nathan Post, Danielle Eddy, Catherine Huntley, May C. I. van Schalkwyk, Madhumita Shrotri, David Leeman, Samuel Rigby, Sarah V. Williams, William H. Bermingham, Paul Kellam, John Maher, Adrian M. Shields, Gayatri Amirthalingam, Sharon J. Peacock, Sharif A. Ismail

Background: Progress in characterising the humoral immune response to Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) has been rapid but…
PLOS ONE SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsets
December 31, 2020 Sanja Matic, Suzana Popovic, Predrag Djurdjevic, Danijela Todorovic, Natasa Djordjevic, Zeljko Mijailovic, Predrag Sazdanovic, Dragan Milovanovic, Dejana Ruzic Zecevic, Marina Petrovic, Maja Sazdanovic, Nenad Zornic, Vladimir Vukicevic, Ivana Petrovic, Snezana Matic, Marina Karic Vukicevic, Dejan Baskic

Clinical manifestations of SARS-CoV-2 infection range from mild to critically severe. The aim of the study was to highlight the…
PLOS ONE Severity of COVID-19 at elevated exposure to perfluorinated alkylates
December 31, 2020 Philippe Grandjean, Clara Amalie Gade Timmermann, Marie Kruse, Flemming Nielsen, Pernille Just Vinholt, Lasse Boding, Carsten Heilmann, Kåre Mølbak

Background: The course of coronavirus disease 2019 (COVID-19) seems to be aggravated by air pollution, and some industrial chemicals, such…
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NIAID/NIH

PLOS ONE The use of methylprednisolone in COVID-19 patients: A propensity score matched retrospective cohort study
December 31, 2020 Xiang You, Chao-hui Wu, Ya-nan Fu, Zonglin He, Pin-fang Huang, Gong-ping Chen, Cui-hong Lin, Wai-kit Ming, Rong-fang Lin

Purpose: To evaluate the efficacy and safety of methylprednisolone in treating the coronavirus disease 2019 (COVID-19) patients. Methods: A…
PLOS Medicine Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis
December 30, 2020 Min Seo Kim, Min Ho An, Won Jun Kim, Tae-Ho Hwang

Background: Numerous clinical trials and observational studies have investigated various pharmacological agents as potential treatment for…
PLOS ONE Safety, tolerability, and outcomes of losartan use in patients hospitalized with SARS-CoV-2 infection: A feasibility study
December 30, 2020 Olena Bolotova, Jeanwoo Yoo, Imran Chaudhri, Luis A. Marcos, Haseena Sahib, Farrukh M. Koraishy, Hal Skopicki, Sahar Ahmad, Sandeep K. Mallipattu

Background: Retrospective studies on the use of Renin-Angiotensin-Aldosterone System blockade in patients with Coronavirus Disease 2019…
PLOS ONE Time to recovery and its predictors among adults hospitalized with COVID-19: A prospective cohort study in Ethiopia
December 30, 2020 Saro Abdella Abrahim, Masresha Tessema, Atkure Defar, Alemayehu Hussen, Eshetu Ejeta, Getachew Demoz, Addisu Birhanu Tereda, Enatenesh Dillnessa, Altaye Feleke, Misiker Amare, Frehiwot Nigatu, Yaregal Fufa, Hailu Refera, Ayalew Aklilu, Munir Kassa, Tsigereda Kifle, Susan Whiting, Getachew Tollera, Ebba Abate

Background: Various factors may determine the duration of viral shedding (the time from infection to viral RNA-negative conversion or…
PLOS ONE Coronary calcium scoring assessed on native screening chest CT imaging as predictor for outcome in COVID-19: An analysis of a hospitalized German cohort
December 30, 2020 Gregor S. Zimmermann, Alexander A. Fingerle, Christina Müller-Leisse, Felix Gassert, Claudio E. von Schacky, Tareq Ibrahim, Karl-Ludwig Laugwitz, Fabian Geisler, Christoph Spinner, Bernhard Haller, Markus R. Makowski, Jonathan Nadjiri

Background: Since the outbreak of the COVID-19 pandemic, a number of risk factors for a poor outcome have been identified. Thereby,…
PLOS Computational Biology The COVID-19 outbreak in Sichuan, China: Epidemiology and impact of interventions
December 28, 2020 Quan-Hui Liu, Ana I. Bento, Kexin Yang, Hang Zhang, Xiaohan Yang, Stefano Merler, Alessandro Vespignani, Jiancheng Lv, Hongjie Yu, Wei Zhang, Tao Zhou, Marco Ajelli

In January 2020, a COVID-19 outbreak was detected in Sichuan Province of China. Six weeks later, the outbreak was successfully contained.…
PLOS ONE Epidemiology, clinical characteristics, household transmission, and lethality of severe acute respiratory syndrome coronavirus-2 infection among healthcare workers in Ontario, Canada
December 28, 2020 Kevin L. Schwartz, Camille Achonu, Sarah A. Buchan, Kevin A. Brown, Brenda Lee, Michael Whelan, Julie HC Wu, Gary Garber

Introduction: Protecting healthcare workers (HCWs) from Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a priority to…
PLOS ONE Seroprevalence of SARS-CoV-2 IgG specific antibodies among healthcare workers in the Northern Metropolitan Area of Barcelona, Spain, after the first pandemic wave
December 28, 2020 Jaume Barallat, Gema Fernández-Rivas, Bibiana Quirant-Sánchez, Victoria González, Maria Doladé, Eva Martinez-Caceres, Monica Piña, Joan Matllo, Oriol Estrada, Ignacio Blanco

Background: The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) around the world has caused a global pandemic,…
PLOS ONE COVID-19 disease—Temporal analyses of complete blood count parameters over course of illness, and relationship to patient demographics and management outcomes in survivors and non-survivors: A longitudinal descriptive cohort study
December 28, 2020 Simone Lanini, Chiara Montaldo, Emanuele Nicastri, Francesco Vairo, Chiara Agrati, Nicola Petrosillo, Paola Scognamiglio, Andrea Antinori, Vincenzo Puro, Antonino Di Caro, Gabriella De Carli, Assunta Navarra, Alessandro Agresta, Claudia Cimaglia, Fabrizio Palmieri, Gianpiero D’Offizi, Luisa Marchioni, Gary Pignac Kobinger, Markus Maeurer, Enrico Girardi, Maria Rosaria Capobianchi, Alimuddin Zumla, Franco Locatelli, Giuseppe Ippolito

Background: Detailed temporal analyses of complete (full) blood count (CBC) parameters, their evolution and relationship to patient age,…
PLOS ONE High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy
December 28, 2020 Jacob S. Stevens, Kristen L. King, Shelief Y. Robbins-Juarez, Pascale Khairallah, Katherine Toma, Hector Alvarado Verduzco, Emily Daniel, Denzil Douglas, Andrew A. Moses, Yonatan Peleg, Piotr Starakiewicz, Miah T. Li, Daniel W. Kim, Kathleen Yu, Long Qian, Vaqar H. Shah, Max R. O'Donnell, Matthew J. Cummings, Jason Zucker, Karthik Natarajan, Adler Perotte, Demetra Tsapepas, Kiryluk Krzysztof, Geoffrey Dube, Eric Siddall, Shayan Shirazian, Thomas L. Nickolas, Maya K. Rao, Jonathan M. Barasch, Anthony M. Valeri, Jai Radhakrishnan, Ali G. Gharavi, S. Ali Husain, Sumit Mohan

Introduction: A large proportion of patients with COVID-19 develop acute kidney injury (AKI). While the most severe of these cases require…
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Image by Bokskapet from Pixabay

PLOS ONE Cardiac arrhythmias in hospitalized patients with COVID-19: A prospective observational study in the western United States
December 28, 2020 Jae Hyung Cho, Ali Namazi, Richard Shelton, Archana Ramireddy, Ashkan Ehdaie, Michael Shehata, Xunzhang Wang, Eduardo Marbán, Sumeet S. Chugh, Eugenio Cingolani

Arrhythmias have been reported frequently in COVID-19 patients, but the incidence and nature have not been well characterized. Patients…
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NIAID/NIH

PLOS ONE Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
December 28, 2020 Fernando Mejía, Carlos Medina, Enrique Cornejo, Enrique Morello, Sergio Vásquez, Jorge Alave, Alvaro Schwalb, Germán Málaga

Introduction: Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim…
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NIAID/NIH

PLOS ONE Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
December 28, 2020 Pau Cerdà, Jesus Ribas, Adriana Iriarte, José María Mora-Luján, Raquel Torres, Belén del Río, Héctor Ignacio Jofre, Yolanda Ruiz, Marta Huguet, Mari Paz Fuset, Sergio Martínez-Yélamos, Salud Santos, Núria Llecha, Xavier Corbella, Antoni Riera-Mestre

Background: A higher incidence of thrombotic events, mainly pulmonary embolism (PE), has been reported in hospitalized patients with…
PLOS ONE Estimation of the incubation period of COVID-19 in Vietnam
December 23, 2020 Long V. Bui, Ha T. Nguyen, Hagai Levine, Ha N. Nguyen, Thu-Anh Nguyen, Thuy P. Nguyen, Truong T. Nguyen, Toan T. T. Do, Ngoc T. Pham, My Hanh Bui

Objective: To estimate the incubation period of Vietnamese confirmed COVID-19 cases. Methods: Only confirmed COVID-19 cases who are…
PLOS ONE Calcification of the thoracic aorta on low-dose chest CT predicts severe COVID-19
December 23, 2020 Philipp Fervers, Jonathan Kottlors, David Zopfs, Johannes Bremm, David Maintz, Orkhan Safarov, Stephanie Tritt, Nuran Abdullayev, Thorsten Persigehl

Background: Cardiovascular comorbidity anticipates poor prognosis of SARS-CoV-2 disease (COVID-19) and correlates with the systemic…
PLOS ONE A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidates
December 23, 2020 Donald A. Berry, Scott Berry, Peter Hale, Leah Isakov, Andrew W. Lo, Kien Wei Siah, Chi Heem Wong

We compare and contrast the expected duration and number of infections and deaths averted among several designs for clinical trials of…
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National Institute of Allergy and Infectious Diseases, NIH

PLOS Neglected Tropical Diseases Mild manifestations of COVID-19 in healthcare workers
December 22, 2020 Jingwen Li, Xi Long, Qing Zhang, Xi Fang, Na Li, Zhicheng Lin, Jinghong Li, Nian Xiong

Medical staff treating Coronavirus Disease 2019 (COVID-19) patients are at high risk for exposure to Severe Acute Respiratory Syndrome…
PLOS ONE A spatial-temporal description of the SARS-CoV-2 infections in Indonesia during the first six months of outbreak
December 22, 2020 Dewi Nur Aisyah, Chyntia Aryanti Mayadewi, Haniena Diva, Zisis Kozlakidis, Siswanto, Wiku Adisasmito

Background: Since the first cases reported in Wuhan, China, in December 2019, the Severe Acute Respiratory Syndrome Coronavirus 2…
PLOS ONE COVID-19 pandemic in Djibouti: Epidemiology and the response strategy followed to contain the virus during the first two months, 17 March to 16 May 2020
December 22, 2020 Mohamed Elhakim, Saleh Banoita Tourab, Ahmed Zouiten

First cases of COVID-19 were reported from Wuhan, China, in December 2019, and it progressed rapidly. On 30 January, WHO declared the new…
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Image by Ralf Kunze from Pixabay

PLOS ONE Obesity and smoking as risk factors for invasive mechanical ventilation in COVID-19: A retrospective, observational cohort study
December 22, 2020 Ana C. Monteiro, Rajat Suri, Iheanacho O. Emeruwa, Robert J. Stretch, Roxana Y. Cortes-Lopez, Alexander Sherman, Catherine C. Lindsay, Jennifer A. Fulcher, David Goodman-Meza, Anil Sapru, Russell G. Buhr, Steven Y. Chang, Tisha Wang, Nida Qadir

Purpose: To describe the trajectory of respiratory failure in COVID-19 and explore factors associated with risk of invasive mechanical…
PLOS ONE Manufacturing of convalescent plasma of COVID-19 patients: Aspects of quality
December 22, 2020 Viola Hähnel, David Peterhoff, Veronika Bäuerlein, Andreas-Michael Brosig, Irene Pamler, Christian Johnson, Adelina Bica, Monica Totir, Thomas Ossner, Barbara Stemmer, Martina Toelge, Anja Schütz, Hans-Helmut Niller, Barbara Schmidt, Ralf Wagner, André Gessner, Ralph Burkhard, Robert Offner

The ongoing coronavirus disease 2019 (COVID-19) pandemic emerged in December 2019. Convalescent plasma represents a promising COVID-19…
PLOS ONE Effects of voluntary event cancellation and school closure as countermeasures against COVID-19 outbreak in Japan
December 21, 2020 Yoshiyuki Sugishita, Junko Kurita, Tamie Sugawara, Yasushi Ohkusa

Background: To control the COVID-19 outbreak in Japan, sports and entertainment events were canceled and schools were closed throughout…
PLOS ONE Evaluation of pool-based testing approaches to enable population-wide screening for COVID-19
December 21, 2020 Timo de Wolff, Dirk Pflüger, Michael Rehme, Janin Heuer, Martin-Immanuel Bittner

Objective: Rapid testing is paramount during a pandemic to prevent continued viral spread and excess morbidity and mortality. This study…
PLOS ONE Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia
December 21, 2020 Jean-Louis Georges, Floriane Gilles, Hélène Cochet, Alisson Bertrand, Marie De Tournemire, Victorien Monguillon, Maeva Pasqualini, Alix Prevot, Guillaume Roger, Joseph Saba, Joséphine Soltani, Mehrsa Koukabi-Fradelizi, Jean-Paul Beressi, Cécile Laureana, Jean-François Prost, Bernard Livarek

Background: Angiotensin-converting enzyme 2 is the receptor that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses for…
PLOS ONE A simplified SARS-CoV-2 detection protocol for research laboratories
December 18, 2020 Sean Paz, Christopher Mauer, Anastasia Ritchie, Janet D. Robishaw, Massimo Caputi

Widespread testing is required to limit the current public health crisis caused by the COVID-19 pandemic. Multiple tests protocols have…
PLOS ONE Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study
December 18, 2020 Junior Rika Matangila, Ritha Kibambe Nyembu, Gloire Mosala Telo, Christian Djuba Ngoy, Taty Msueun Sakobo, Joel Mbembo Massolo, Blandine Mbo Muyembe, Richard Kapela Mvwala, Cedric Kabemba Ilunga, Emmanuel Bakilo Limbole, Jeff Mukengeshay Ntalaja, Roger Minga Kongo

Objectives: To describe the clinical characteristics of patients infected with SARS-CoV-2 at Clinique Ngaliema, a public hospital, in…
PLOS Neglected Tropical Diseases Understanding COVID-19 vaccine demand and hesitancy: A nationwide online survey in China
December 17, 2020 Yulan Lin, Zhijian Hu, Qinjian Zhao, Haridah Alias, Mahmoud Danaee, Li Ping Wong

Background: This study attempts to understand coronavirus disease 2019 (COVID-19) vaccine demand and hesitancy by assessing the public’s…
PLOS ONE Characteristics and outcomes of COVID-19 patients in New York City’s public hospital system
December 17, 2020 Roopa Kalyanaraman Marcello, Johanna Dolle, Sheila Grami, Richard Adule, Zeyu Li, Kathleen Tatem, Chinyere Anyaogu, Stephen Apfelroth, Raji Ayinla, Noella Boma, Terence Brady, Braulio F. Cosme-Thormann, Roseann Costarella, Kenra Ford, Kecia Gaither, Jessica Jacobson, Marc Kanter, Stuart Kessler, Ross B. Kristal, Joseph J. Lieber, Vikramjit Mukherjee, Vincent Rizzo Jr., Madden Rowell, David Stevens, Elana Sydney, Andrew Wallach, Dave A. Chokshi, Nichola Davis, New York City Health + Hospitals COVID-19 Population Health Data Team

Background: New York City (NYC) bore the greatest burden of COVID-19 in the United States early in the pandemic. In this case series, we…
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National Institute of Allergy and Infectious Diseases, NIH

PLOS ONE Clinical features and risk factors for severe inpatients with COVID-19: A retrospective study in China
December 17, 2020 Juan Wang, Shuzhen Guo, Yili Zhang, Kuo Gao, Jiacheng Zuo, Nannan Tan, Kangjia Du, Yan Ma, Yong Hou, Quntang Li, Hongming Xu, Jin Huang, Qiuhua Huang, Hui Na, Jingwei Wang, Xiaoyan Wang, Yanhua Xiao, Junteng Zhu, Hong Chen, Zhang Liu, Mingxuan Wang, Linsong Zhang, Wei Wang

Background: A worldwide outbreak of coronavirus disease (COVID-19), since 2019, has brought a disaster to people all over the world. Many…
PLOS ONE Vulnerability of deep neural networks for detecting COVID-19 cases from chest X-ray images to universal adversarial attacks
December 17, 2020 Hokuto Hirano, Kazuki Koga, Kazuhiro Takemoto

Owing the epidemic of the novel coronavirus disease 2019 (COVID-19), chest X-ray computed tomography imaging is being used for effectively…
PLOS ONE Coronavirus-induced coagulopathy during the course of disease
December 17, 2020 Marie Sophie Friedrich, Jan-Dirk Studt, Julia Braun, Donat R. Spahn, Alexander Kaserer

Background: A significant proportion of patients with coronavirus disease 19 (COVID-19) suffer from excessive coagulation activation and…
PLOS ONE Pre-test probability for SARS-Cov-2-related infection score: The PARIS score
December 17, 2020 Mickael Tordjman, Ahmed Mekki, Rahul D. Mali, Ines Saab, Guillaume Chassagnon, Enora Guillo, Robert Burns, Deborah Eshagh, Sebastien Beaune, Guillaume Madelin, Simon Bessis, Antoine Feydy, Fadila Mihoubi, Benoit Doumenc, Luc Mouthon, Robert-Yves Carlier, Jean-Luc Drapé, Marie-Pierre Revel

Introduction: In numerous countries, large population testing is impossible due to the limited availability of RT-PCR kits and CT-scans.…
PLOS ONE Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka
December 17, 2020 Chitra Pattabiraman, Farhat Habib, Harsha P. K., Risha Rasheed, Pramada Prasad, Vijayalakshmi Reddy, Prameela Dinesh, Tina Damodar, Kiran Hosallimath, Anson K. George, Nakka Vijay Kiran Reddy, Banerjee John, Amrita Pattanaik, Narendra Kumar, Reeta S. Mani, Manjunatha M. Venkataswamy, Shafeeq K. Shahul Hameed, Prakash Kumar B. G., Anita Desai, Ravi Vasanthapuram

Karnataka, a state in south India, reported its first case of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection on…
PLOS ONE Prevalence and risk factors of disability and anxiety in a retrospective cohort of 432 survivors of Coronavirus Disease-2019 (Covid-19) from China
December 17, 2020 Siyi Zhu, Qiang Gao, Lin Yang, Yonghong Yang, Wenguang Xia, Xiguo Cai, Yanping Hui, Di Zhu, Yanyan Zhang, Guiqing Zhang, Shuang Wu, Yiliang Wang, Zhiqiang Zhou, Hongfei Liu, Changjie Zhang, Bo Zhang, Jianrong Yang, Mei Feng, Zhong Ni, Baoyu Chen, Chunping Du, Hongchen He, Yun Qu, Quan Wei, Chengqi He, Jan D. Reinhardt

Objective: To estimate the prevalence of disability and anxiety in Covid-19 survivors at discharge from hospital and analyze relative risk…
PLOS ONE An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19
December 17, 2020 Lucy Chimoyi, Kavindhran Velen, Gavin J. Churchyard, Robert Wallis, James J. Lewis, Salome Charalambous

As the SARS-CoV2 pandemic has progressed, there have been marked geographical differences in the pace and extent of its spread. We…
PLOS ONE Outcomes of an intermediate respiratory care unit in the COVID-19 pandemic
December 16, 2020 Javier Carrillo Hernandez-Rubio, Maria Sanchez-Carpintero Abad, Andrea Yordi Leon, Guillermo Doblare Higuera, Leticia Garcia Rodriguez, Carmen Garcia Torrejon, Alejandro Mayor Cacho, Angel Jimenez Rodriguez, Mercedes Garcia-Salmones Martin

Background: 15% of COVID-19 patients develop severe pneumonia. Non-invasive mechanical ventilation and high-flow nasal cannula can reduce…
PLOS ONE Validation and repurposing of the MSL-COVID-19 score for prediction of severe COVID-19 using simple clinical predictors in a triage setting: The Nutri-CoV score
December 16, 2020 Omar Yaxmehen Bello-Chavolla, Neftali E. Antonio-Villa, Edgar Ortiz-Brizuela, Arsenio Vargas-Vázquez, María Fernanda González-Lara, Alfredo Ponce de Leon, José Sifuentes-Osornio, Carlos A. Aguilar-Salinas

Background: During the COVID-19 pandemic, risk stratification has been used to decide patient eligibility for inpatient, critical and…
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National Institute of Allergy and Infectious Diseases, NIH

PLOS ONE Glucocorticoids with low-dose anti-IL1 anakinra rescue in severe non-ICU COVID-19 infection: A cohort study
December 16, 2020 Raphael Borie, Laurent Savale, Antoine Dossier, Jade Ghosn, Camille Taillé, Benoit Visseaux, Kamel Jebreen, Abourahmane Diallo, Chloe Tesmoingt, Lise Morer, Tiphaine Goletto, Nathalie Faucher, Linda Hajouji, Catherine Neukirch, Mathilde Phillips, Sandrine Stelianides, Lila Bouadma, Solenn Brosseau, Sébastien Ottaviani, Johan Pluvy, Diane Le Pluart, Marie-Pierre Debray, Agathe Raynaud-Simon, Diane Descamps, Antoine Khalil, Jean Francois Timsit, Francois-Xavier Lescure, Vincent Descamps, Thomas Papo, Marc Humbert, Bruno Crestani, Philippe Dieude, Eric Vicaut, Gérard Zalcman, on behalf of Bichat & Kremlin-Bicêtre AP-HP COVID teams

Background: The optimal treatment for patients with severe coronavirus-19 disease (COVID-19) and hyper-inflammation remains debated.…
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NIH

PLOS ONE Clinical outcomes and inflammatory marker levels in patients with Covid-19 and obesity at an inner-city safety net hospital
December 16, 2020 Anahita Mostaghim, Pranay Sinha, Catherine Bielick, Selby Knudsen, Indeevar Beeram, Laura F. White, Caroline Apovian, Manish Sagar, Natasha S. Hochberg

Objectives: Patients with Covid-19 and obesity have worse clinical outcomes which may be driven by increased inflammation. This study aimed…
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NIAID-RML

PLOS ONE Metabolic risk factors and risk of Covid-19: A systematic review and meta-analysis
December 15, 2020 Bahram Moazzami, Shahla Chaichian, Amir Kasaeian, Shirin Djalalinia, Meisam Akhlaghdoust, Masoud Eslami, Behrooz Broumand

Objective: Based on the epidemiologic findings of Covid-19 incidence; illness and mortality seem to be associated with metabolic risk…
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Image by Tumisu from Pixabay

PLOS ONE Human agency and infection rates: Implications for social distancing during epidemics
December 15, 2020 Christopher Bronk Ramsey

Social distancing is an important measure in controlling epidemics. This paper presents a simple theoretical model focussed on the…
PLOS ONE COVID-19: Spatial analysis of hospital case-fatality rate in France
December 15, 2020 Marc Souris, Jean-Paul Gonzalez

When the population risk factors and reporting systems are similar, the assessment of the case-fatality (or lethality) rate (ratio of…
PLOS ONE Clinical characteristics and outcomes of critically ill patients with COVID-19 admitted to an intensive care unit in London: A prospective observational cohort study
December 15, 2020 Ross J. Thomson, Jennifer Hunter, Jonathan Dutton, James Schneider, Maryam Khosravi, Alisha Casement, Kulwant Dhadwal, Daniel Martin

Background: Cohorts of severely ill patients with COVID-19 have been described in several countries around the globe, but to date there…
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NIAID-RML

PLOS ONE Coagulation profile of COVID-19 patients admitted to the ICU: An exploratory study
December 15, 2020 Thiago Domingos Corrêa, Ricardo Luiz Cordioli, João Carlos Campos Guerra, Bruno Caldin da Silva, Roseny dos Reis Rodrigues, Guilherme Martins de Souza, Thais Dias Midega, Niklas Söderberg Campos, Bárbara Vieira Carneiro, Flávia Nunes Dias Campos, Hélio Penna Guimarães, Gustavo Faissol Janot de Matos, Valdir Fernandes de Aranda, Leonardo José Rolim Ferraz

Background: Coagulation abnormalities in COVID-19 patients have not been addressed in depth. Objective: To perform a longitudinal…
PLOS ONE Characteristics, comorbidities and survival analysis of young adults hospitalized with COVID-19 in New York City
December 14, 2020 Brian L. Altonen, Tatiana M. Arreglado, Ofelia Leroux, Max Murray-Ramcharan, Ryan Engdahl

This study reviewed 395 young adults, 18–35 year-old, admitted for COVID-19 to one of the eleven hospitals in New York City public health…
PLOS ONE Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients
December 14, 2020 Marina Laplana, Oriol Yuguero, Joan Fibla

Background: The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its…
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NIAID-RML

PLOS ONE Correlation between hospitalized patients’ demographics, symptoms, comorbidities, and COVID-19 pandemic in Bahia, Brazil
December 14, 2020 Márcio C. F. Macedo, Isabelle M. Pinheiro, Caio J. L. Carvalho, Hilda C. J. R. Fraga, Isaac P. C. Araujo, Simone S. Montes, Otávio A. C. Araujo, Lucas A. Alves, Hugo Saba, Márcio L. V. Araújo, Ivonete T. L. Queiroz, Romilson L. Sampaio, Márcia S. P. L. Souza, Ana Claudia F. N. da Silva, Antonio C. S. Souza

In this paper, we provide a retrospective cohort study with patients that have been hospitalized for general or intensive care unit…
PLOS ONE Safe contact tracing for COVID-19: A method without privacy breach using functional encryption techniques based-on spatio-temporal trajectory data
December 11, 2020 Wooil Kim, Hyubjin Lee, Yon Dohn Chung

The COVID-19 pandemic has spread all over the globe. In the absence of a vaccine, a small number of countries have managed to control the…
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NIAID-RML

PLOS ONE Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection
December 11, 2020 Laurie G. Jacobs, Elli Gourna Paleoudis, Dineen Lesky-Di Bari, Themba Nyirenda, Tamara Friedman, Anjali Gupta, Lily Rasouli, Marygrace Zetkulic, Bindu Balani, Chinwe Ogedegbe, Harinder Bawa, Lauren Berrol, Nabiha Qureshi, Judy L. Aschner

Background: Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and…
PLOS ONE Behavioral preventive measures and the use of medicines and herbal products among the public in response to Covid-19 in Bangladesh: A cross-sectional study
December 11, 2020 Iftekhar Ahmed, Maruf Hasan, Rahima Akter, Bidduth Kumar Sarkar, Marufa Rahman, Md Samun Sarker, Mohammed A. Samad

The present study was conducted to assess the behavioral preventive measures and the use of medicines and herbal foods/products among the…
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Image by Pexels from Pixabay

PLOS ONE Universal screening for SARS-CoV-2 infection among pregnant women at Elmhurst Hospital Center, Queens, New York
December 10, 2020 Sheela Maru, Uday Patil, Rachel Carroll-Bennett, Aaron Baum, Tracy Bohn-Hemmerdinger, Andrew Ditchik, Michael L. Scanlon, Parvathy Krishnan, Kelly Bogaert, Carson Woodbury, Duncan Maru, Lawrence Noble, Randi Wasserman, Barry Brown, Rachel Vreeman, Joseph Masci

Background: Universal screening for SARS-CoV-2 infection on Labor and Delivery (L&D) units is a critical strategy to manage patient and…
PLOS ONE Can the detection dog alert on COVID-19 positive persons by sniffing axillary sweat samples? A proof-of-concept study
December 10, 2020 Dominique Grandjean, Riad Sarkis, Clothilde Lecoq-Julien, Aymeric Benard, Vinciane Roger, Eric Levesque, Eric Bernes-Luciani, Bruno Maestracci, Pascal Morvan, Eric Gully, David Berceau-Falancourt, Pierre Haufstater, Gregory Herin, Joaquin Cabrera, Quentin Muzzin, Capucine Gallet, Hélène Bacqué, Jean-Marie Broc, Leo Thomas, Anthony Lichaa, Georges Moujaes, Michele Saliba, Aurore Kuhn, Mathilde Galey, Benoit Berthail, Lucien Lapeyre, Anthoni Capelli, Steevens Renault, Karim Bachir, Anthony Kovinger, Eric Comas, Aymeric Stainmesse, Erwan Etienne, Sébastien Voeltzel, Sofiane Mansouri, Marlène Berceau-Falancourt, Aimé Dami, Lary Charlet, Eric Ruau, Mario Issa, Carine Grenet, Christophe Billy, Jean-Pierre Tourtier, Loïc Desquilbet

The aim of this proof-of-concept study was to evaluate if trained dogs could discriminate between sweat samples from symptomatic COVID-19…
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Image by Antonio Corigliano from Pixabay

PLOS ONE Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis
December 10, 2020 Alejandro Piscoya, Luis F. Ng-Sueng, Angela Parra del Riego, Renato Cerna-Viacava, Vinay Pasupuleti, Yuani M. Roman, Priyaleela Thota, C. Michael White, Adrian V. Hernandez

Background: Efficacy and safety of treatments for hospitalized COVID-19 are uncertain. We systematically reviewed efficacy and safety of…
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NIAID-RML

PLOS ONE Analyzing changes in respiratory rate to predict the risk of COVID-19 infection
December 10, 2020 Dean J. Miller, John V. Capodilupo, Michele Lastella, Charli Sargent, Gregory D. Roach, Victoria H. Lee, Emily R. Capodilupo

COVID-19, the disease caused by the SARS-CoV-2 virus, can cause shortness of breath, lung damage, and impaired respiratory function.…
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National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH

PLOS ONE COVID-19 hospitalizations in Brazil’s Unified Health System (SUS)
December 10, 2020 Carla Lourenço Tavares de Andrade, Claudia Cristina de Aguiar Pereira, Mônica Martins, Sheyla Maria Lemos Lima, Margareth Crisóstomo Portela

Objective: To study the profile of hospitalizations due to COVID-19 in the Unified Health System (SUS) in Brazil and to identify factors…
PLOS ONE Epidemiological profile of SARS-CoV-2 among selected regions in Ghana: A cross-sectional retrospective study
December 10, 2020 Michael Owusu, Augustina Angelina Sylverken, Sampson Twumasi Ankrah, Philip El-Duah, Nana Kwame Ayisi-Boateng, Richmond Yeboah, Richmond Gorman, Jesse Asamoah, Tabea Binger, Godfred Acheampong, Franklin Asiedu Bekoe, Sally-Ann Ohene, Rita Larsen-Reindorf, Anthony Afum-Adjei Awuah, John Amuasi, Ellis Owusu-Dabo, Yaw Adu-Sarkodie, Richard Odame Phillips

Background: Global cases of COVID-19 continue to rise, causing havoc to several economies. So far, Ghana has recorded 48,643 confirmed…
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National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH

PLOS ONE Impact of chronic liver disease upon admission on COVID-19 in-hospital mortality: Findings from COVOCA study
December 10, 2020 Raffaele Galiero, Pia Clara Pafundi, Vittorio Simeon, Luca Rinaldi, Alessandro Perrella, Erica Vetrano, Alfredo Caturano, Maria Alfano, Domenico Beccia, Riccardo Nevola, Raffaele Marfella, Celestino Sardu, Carmine Coppola, Ferdinando Scarano, Paolo Maggi, Pellegrino De Lucia Sposito, Laura Vocciante, Carolina Rescigno, Costanza Sbreglia, Fiorentino Fraganza, Roberto Parrella, Annamaria Romano, Giosuele Calabria, Benedetto Polverino, Antonio Pagano, Carolina Bologna, Maria Amitrano, Vincenzo Esposito, Nicola Coppola, Nicola Maturo, Luigi Elio Adinolfi, Paolo Chiodini, Ferdinando Carlo Sasso, on behalf of COVOCA Study Group

Background: Italy has been the first Western country to be heavily affected by the spread of SARS-COV-2 infection and among the pioneers of…
PLOS ONE The local stability of a modified multi-strain SIR model for emerging viral strains
December 9, 2020 Miguel Fudolig, Reka Howard

We study a novel multi-strain SIR epidemic model with selective immunity by vaccination. A newer strain is made to emerge in the…
PLOS ONE Transmissibility of COVID-19 depends on the viral load around onset in adult and symptomatic patients
December 9, 2020 Hitoshi Kawasuji, Yusuke Takegoshi, Makito Kaneda, Akitoshi Ueno, Yuki Miyajima, Koyomi Kawago, Yasutaka Fukui, Yoshihiro Yoshida, Miyuki Kimura, Hiroshi Yamada, Ippei Sakamaki, Hideki Tani, Yoshitomo Morinaga, Yoshihiro Yamamoto

Objective: To investigate the relationship between viral load and secondary transmission in novel coronavirus disease 2019 (COVID-19).…
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National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH

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