The novel coronavirus responsible for COVID-19 was first identified in Hubei Province, China in December, 2019. Within a matter of months…
Biology & Life Sciences
COVID-19 pandemic (2019-20)
This Collection of articles highlights all content published across the PLOS journals relating to the COVID-19 pandemic in 2019-20.
PLOS is committed to disseminating research as quickly as possible, particularly in public health emergencies.
All articles published in any PLOS journal are Open Access free of charge to all readers.
Image Credit: US NIH/Public domain (CC-0) and Senado Federal/Flickr (CC-BY)
Clinical Epidemiology and Care
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PLOS ONE Effects of short-term travel on COVID-19 spread: A novel SEIR model and case study in Minnesota
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PLOS ONE The independent factors associated with oxygen therapy in COVID-19 patients under 65 years old
Background: The number of hospitalized young coronavirus disease 2019 (COVID-19) patients has increased significantly. However, specific…
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PLOS ONE COVID-19 prevalence and predictors in United States adults during peak stay-at-home orders
Background: Early recognition of COVID-19 cases is essential for effective public health measures aimed at isolation of individuals…
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PLOS ONE Rapid conversion of an in-patient hospital unit to accommodate COVID-19: An interdisciplinary human factors, ethnography, and infection prevention and control approach
Background: In response to the Coronavirus disease-19 (COVID-19) pandemic, in-patient units in hospitals around the world have altered…
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PLOS ONE Incidence and characterization of acute pulmonary embolism in patients with SARS-CoV-2 pneumonia: A multicenter Italian experience
Background and aims: Several studies reported a high incidence of pulmonary embolism (PE) among patients with severe acute respiratory…
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PLOS ONE Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study
Objectives: We aimed to derive and validate a triage tool, based on clinical assessment alone, for predicting adverse outcome in acutely…
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PLOS ONE Development and validation of a clinical risk score to predict the risk of SARS-CoV-2 infection from administrative data: A population-based cohort study from Italy
Background: The novel coronavirus (SARS-CoV-2) pandemic spread rapidly worldwide increasing exponentially in Italy. To date, there is lack…
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PLOS ONE Characteristics and predicting factors of Corona Virus Disease-2019 (COVID-19) among healthcare providers in a developing country
A limited number of publications have identified risk factors for Corona Virus Disease 2019 (COVID-19) among Healthcare Providers (HCPs).…
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PLOS ONE Converting the maybes: Crucial for a successful COVID-19 vaccination strategy
Background: Broad community acceptance of a COVID-19 vaccination will be critical for effectively halting the spread of the virus. In this…
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PLOS ONE Medical resources and coronavirus disease (COVID-19) mortality rate: Evidence and implications from Hubei province in China
In light of the ongoing coronavirus disease (COVID-19) pandemic, this study aims to examine the relationship between the availability of…
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PLOS ONE Impact of SARS-CoV-2 pandemic among health care workers in a secondary teaching hospital in Spain
Background: The COVID-19 pandemic has posed a huge challenge to healthcare systems and their personnel worldwide. The study of the impact…
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PLOS ONE High-risk chest radiographic features associated with COVID-19 disease severity
Objectives: High-risk CXR features in COVID-19 are not clearly defined. We aimed to identify CXR features that correlate with severe…
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PLOS ONE Health conditions of potential risk for severe Covid-19 in institutionalized elderly people
The objective of this study was to identify the health conditions considered potential risk factors for severe Covid-19 and analyze its…
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PLOS ONE Clinical and radiological findings of adult hospitalized patients with community-acquired pneumonia from SARS-CoV-2 and endemic human coronaviruses
Endemic human coronaviruses (HCoVs) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are members of the family…
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PLOS Pathogens Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina
We report the emergency development and application of a robust serologic test to evaluate acute and convalescent antibody responses to…
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PLOS ONE Earliest detection to date of SARS-CoV-2 in Florida: Identification together with influenza virus on the main entry door of a university building, February 2020
In February and March, 2020, environmental surface swab samples were collected from the handle of the main entry door of a major…
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PLOS ONE Sex differences in susceptibility, severity, and outcomes of coronavirus disease 2019: Cross-sectional analysis from a diverse US metropolitan area
Introduction: Sex is increasingly recognized as an important factor in the epidemiology and outcome of many diseases. This also appears to…
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PLOS ONE Impact of first wave of SARS-CoV-2 infection in patients with Systemic Lupus Erythematosus: Weighting the risk of infection and flare
Introduction: The aim of this study was to investigate the incidence and clinical presentation of SARS-CoV-2 infections in a Systemic Lupus…
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PLOS ONE Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19
Background: Treatment of severely ill COVID-19 patients requires simultaneous management of oxygenation and inflammation without…
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PLOS ONE Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2)
Drug repurposing for COVID-19 has several potential benefits including shorter development time, reduced costs and regulatory support for…
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PLOS Neglected Tropical Diseases COVID-19, leprosy, and neutrophils
Coronavirus Disease 2019 (COVID-19), a disease caused by the betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2),…
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PLOS Computational Biology The value of decreasing the duration of the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
Finding medications or vaccines that may decrease the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
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PLOS Neglected Tropical Diseases Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
Wuhan City (WH) in China was the first place to report COVID-19 in the world and the outbreak of COVID-19 was controlled in March of 2020…
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PLOS ONE Therapeutic plasma exchange for coronavirus disease-2019 triggered cytokine release syndrome; a retrospective propensity matched control study
Background: Cytokine release syndrome (CRS) plays a pivotal role in the pathophysiology and progression of Coronavirus disease-2019…
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PLOS ONE A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients
Purpose: COVID-19 pandemic has multifaceted presentations with rising evidence of immune-mediated mechanisms underplay. We sought to…
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PLOS ONE Mortality and other outcomes of patients with coronavirus disease pneumonia admitted to the emergency department: A prospective observational Brazilian study
Background: The first cases of coronavirus disease (COVID-19) in Brazil were diagnosed in February 2020. Our Emergency Department (ED) was…
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PLOS Neglected Tropical Diseases Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in China
Background: Until now, no antiviral treatment has been proven to be effective for the coronavirus disease 2019 (COVID-19). The timing of…
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PLOS ONE Optimal periodic closure for minimizing risk in emerging disease outbreaks
Without vaccines and treatments, societies must rely on non-pharmaceutical intervention strategies to control the spread of emerging…
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PLOS ONE The efficacy and safety of hydroxychloroquine for COVID-19 prophylaxis: A systematic review and meta-analysis of randomized trials
Background: Populations such as healthcare workers (HCW) that are unable to practice physical distancing are at high risk of acquiring…
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PLOS ONE Covert cases of Severe Acute Respiratory Syndrome Coronavirus 2: An obscure but present danger in regions endemic for Dengue and Chikungunya viruses
Background: The impact of SARS-CoV-2 in regions endemic for both Dengue and Chikungunya is still not fully understood. Considering that…
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PLOS ONE The chronic kidney disease and acute kidney injury involvement in COVID-19 pandemic: A systematic review and meta-analysis
Background: Currently, the SARS-CoV-2 promptly spread across China and around the world. However, there are controversies about whether…
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PLOS ONE The association of chest radiographic findings and severity scoring with clinical outcomes in patients with COVID-19 presenting to the emergency department of a tertiary care hospital in Pakistan
Introduction: While chest x-rays (CXRs) represent a cost-effective imaging modality for developing countries like Pakistan, their utility…
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PLOS ONE Propagation of viral bioaerosols indoors
Here we look into the spread of aerosols indoors that may potentially carry viruses. Many viruses, including the novel SARS-CoV-2, are…
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PLOS Neglected Tropical Diseases Zinc against COVID-19? Symptom surveillance and deficiency risk groups
A wide variety of symptoms is associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and these symptoms…
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PLOS Pathogens The role of Neuropilin-1 in COVID-19
Neuropilin-1 (NRP-1), a member of a family of signaling proteins, was shown to serve as an entry factor and potentiate SARS Coronavirus 2…
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PLOS ONE The role of CPAP as a potential bridge to invasive ventilation and as a ceiling-of-care for patients hospitalized with Covid-19—An observational study
Background: Continuous positive airway pressure (CPAP) ventilation may be used as a potential bridge to invasive mechanical ventilation…
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PLOS ONE The risk factors for mortality of diabetic patients with severe COVID-19: A retrospective study of 167 severe COVID-19 cases in Wuhan
Diabetes is one of the most common comorbidities in adult patients with coronavirus disease 2019 (COVID-19). This study aimed to analyze…
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PLOS ONE Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis
Introduction: Coronavirus disease 2019 (COVID-19) appeared in China in December 2019 and has spread around the world. High Interleukin-6…
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PLOS ONE Spatiotemporal spread pattern of the COVID-19 cases in China
The COVID-19 pandemic is currently spreading widely around the world, causing huge threats to public safety and global society. This study…
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PLOS ONE SARS-CoV-2 PCR cycle threshold at hospital admission associated with patient mortality
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cycle threshold (Ct) has been suggested as an approximate measure…
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PLOS ONE Antibody response to SARS-CoV-2 infection in humans: A systematic review
Background: Progress in characterising the humoral immune response to Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) has been rapid but…
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PLOS ONE SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsets
Clinical manifestations of SARS-CoV-2 infection range from mild to critically severe. The aim of the study was to highlight the…
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PLOS ONE Severity of COVID-19 at elevated exposure to perfluorinated alkylates
Background: The course of coronavirus disease 2019 (COVID-19) seems to be aggravated by air pollution, and some industrial chemicals, such…
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PLOS ONE The use of methylprednisolone in COVID-19 patients: A propensity score matched retrospective cohort study
Purpose: To evaluate the efficacy and safety of methylprednisolone in treating the coronavirus disease 2019 (COVID-19) patients. Methods: A…
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PLOS Medicine Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis
Background: Numerous clinical trials and observational studies have investigated various pharmacological agents as potential treatment for…
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PLOS ONE Safety, tolerability, and outcomes of losartan use in patients hospitalized with SARS-CoV-2 infection: A feasibility study
Background: Retrospective studies on the use of Renin-Angiotensin-Aldosterone System blockade in patients with Coronavirus Disease 2019…
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PLOS ONE Time to recovery and its predictors among adults hospitalized with COVID-19: A prospective cohort study in Ethiopia
Background: Various factors may determine the duration of viral shedding (the time from infection to viral RNA-negative conversion or…
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PLOS ONE Coronary calcium scoring assessed on native screening chest CT imaging as predictor for outcome in COVID-19: An analysis of a hospitalized German cohort
Background: Since the outbreak of the COVID-19 pandemic, a number of risk factors for a poor outcome have been identified. Thereby,…
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PLOS Computational Biology The COVID-19 outbreak in Sichuan, China: Epidemiology and impact of interventions
In January 2020, a COVID-19 outbreak was detected in Sichuan Province of China. Six weeks later, the outbreak was successfully contained.…
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PLOS ONE Epidemiology, clinical characteristics, household transmission, and lethality of severe acute respiratory syndrome coronavirus-2 infection among healthcare workers in Ontario, Canada
Introduction: Protecting healthcare workers (HCWs) from Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a priority to…
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PLOS ONE Seroprevalence of SARS-CoV-2 IgG specific antibodies among healthcare workers in the Northern Metropolitan Area of Barcelona, Spain, after the first pandemic wave
Background: The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) around the world has caused a global pandemic,…
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PLOS ONE COVID-19 disease—Temporal analyses of complete blood count parameters over course of illness, and relationship to patient demographics and management outcomes in survivors and non-survivors: A longitudinal descriptive cohort study
Background: Detailed temporal analyses of complete (full) blood count (CBC) parameters, their evolution and relationship to patient age,…
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PLOS ONE High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy
Introduction: A large proportion of patients with COVID-19 develop acute kidney injury (AKI). While the most severe of these cases require…
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PLOS ONE Cardiac arrhythmias in hospitalized patients with COVID-19: A prospective observational study in the western United States
Arrhythmias have been reported frequently in COVID-19 patients, but the incidence and nature have not been well characterized. Patients…
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PLOS ONE Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
Introduction: Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim…
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PLOS ONE Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
Background: A higher incidence of thrombotic events, mainly pulmonary embolism (PE), has been reported in hospitalized patients with…
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PLOS ONE Estimation of the incubation period of COVID-19 in Vietnam
Objective: To estimate the incubation period of Vietnamese confirmed COVID-19 cases. Methods: Only confirmed COVID-19 cases who are…
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PLOS ONE Calcification of the thoracic aorta on low-dose chest CT predicts severe COVID-19
Background: Cardiovascular comorbidity anticipates poor prognosis of SARS-CoV-2 disease (COVID-19) and correlates with the systemic…
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PLOS ONE A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidates
We compare and contrast the expected duration and number of infections and deaths averted among several designs for clinical trials of…
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PLOS Neglected Tropical Diseases Mild manifestations of COVID-19 in healthcare workers
Medical staff treating Coronavirus Disease 2019 (COVID-19) patients are at high risk for exposure to Severe Acute Respiratory Syndrome…
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PLOS ONE A spatial-temporal description of the SARS-CoV-2 infections in Indonesia during the first six months of outbreak
Background: Since the first cases reported in Wuhan, China, in December 2019, the Severe Acute Respiratory Syndrome Coronavirus 2…
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PLOS ONE COVID-19 pandemic in Djibouti: Epidemiology and the response strategy followed to contain the virus during the first two months, 17 March to 16 May 2020
First cases of COVID-19 were reported from Wuhan, China, in December 2019, and it progressed rapidly. On 30 January, WHO declared the new…
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PLOS ONE Obesity and smoking as risk factors for invasive mechanical ventilation in COVID-19: A retrospective, observational cohort study
Purpose: To describe the trajectory of respiratory failure in COVID-19 and explore factors associated with risk of invasive mechanical…
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PLOS ONE Manufacturing of convalescent plasma of COVID-19 patients: Aspects of quality
The ongoing coronavirus disease 2019 (COVID-19) pandemic emerged in December 2019. Convalescent plasma represents a promising COVID-19…
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PLOS ONE Effects of voluntary event cancellation and school closure as countermeasures against COVID-19 outbreak in Japan
Background: To control the COVID-19 outbreak in Japan, sports and entertainment events were canceled and schools were closed throughout…
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PLOS ONE Evaluation of pool-based testing approaches to enable population-wide screening for COVID-19
Objective: Rapid testing is paramount during a pandemic to prevent continued viral spread and excess morbidity and mortality. This study…
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PLOS ONE Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia
Background: Angiotensin-converting enzyme 2 is the receptor that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses for…
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PLOS ONE A simplified SARS-CoV-2 detection protocol for research laboratories
Widespread testing is required to limit the current public health crisis caused by the COVID-19 pandemic. Multiple tests protocols have…
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PLOS ONE Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study
Objectives: To describe the clinical characteristics of patients infected with SARS-CoV-2 at Clinique Ngaliema, a public hospital, in…
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PLOS Neglected Tropical Diseases Understanding COVID-19 vaccine demand and hesitancy: A nationwide online survey in China
Background: This study attempts to understand coronavirus disease 2019 (COVID-19) vaccine demand and hesitancy by assessing the public’s…
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PLOS ONE Characteristics and outcomes of COVID-19 patients in New York City’s public hospital system
Background: New York City (NYC) bore the greatest burden of COVID-19 in the United States early in the pandemic. In this case series, we…
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PLOS ONE Clinical features and risk factors for severe inpatients with COVID-19: A retrospective study in China
Background: A worldwide outbreak of coronavirus disease (COVID-19), since 2019, has brought a disaster to people all over the world. Many…
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PLOS ONE Vulnerability of deep neural networks for detecting COVID-19 cases from chest X-ray images to universal adversarial attacks
Owing the epidemic of the novel coronavirus disease 2019 (COVID-19), chest X-ray computed tomography imaging is being used for effectively…
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PLOS ONE Coronavirus-induced coagulopathy during the course of disease
Background: A significant proportion of patients with coronavirus disease 19 (COVID-19) suffer from excessive coagulation activation and…
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PLOS ONE Pre-test probability for SARS-Cov-2-related infection score: The PARIS score
Introduction: In numerous countries, large population testing is impossible due to the limited availability of RT-PCR kits and CT-scans.…
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PLOS ONE Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka
Karnataka, a state in south India, reported its first case of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection on…
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PLOS ONE Prevalence and risk factors of disability and anxiety in a retrospective cohort of 432 survivors of Coronavirus Disease-2019 (Covid-19) from China
Objective: To estimate the prevalence of disability and anxiety in Covid-19 survivors at discharge from hospital and analyze relative risk…
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PLOS ONE An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19
As the SARS-CoV2 pandemic has progressed, there have been marked geographical differences in the pace and extent of its spread. We…
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PLOS ONE Outcomes of an intermediate respiratory care unit in the COVID-19 pandemic
Background: 15% of COVID-19 patients develop severe pneumonia. Non-invasive mechanical ventilation and high-flow nasal cannula can reduce…
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PLOS ONE Validation and repurposing of the MSL-COVID-19 score for prediction of severe COVID-19 using simple clinical predictors in a triage setting: The Nutri-CoV score
Background: During the COVID-19 pandemic, risk stratification has been used to decide patient eligibility for inpatient, critical and…
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PLOS ONE Glucocorticoids with low-dose anti-IL1 anakinra rescue in severe non-ICU COVID-19 infection: A cohort study
Background: The optimal treatment for patients with severe coronavirus-19 disease (COVID-19) and hyper-inflammation remains debated.…
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PLOS ONE Clinical outcomes and inflammatory marker levels in patients with Covid-19 and obesity at an inner-city safety net hospital
Objectives: Patients with Covid-19 and obesity have worse clinical outcomes which may be driven by increased inflammation. This study aimed…
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PLOS ONE Metabolic risk factors and risk of Covid-19: A systematic review and meta-analysis
Objective: Based on the epidemiologic findings of Covid-19 incidence; illness and mortality seem to be associated with metabolic risk…
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PLOS ONE Human agency and infection rates: Implications for social distancing during epidemics
Social distancing is an important measure in controlling epidemics. This paper presents a simple theoretical model focussed on the…
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PLOS ONE COVID-19: Spatial analysis of hospital case-fatality rate in France
When the population risk factors and reporting systems are similar, the assessment of the case-fatality (or lethality) rate (ratio of…
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PLOS ONE Clinical characteristics and outcomes of critically ill patients with COVID-19 admitted to an intensive care unit in London: A prospective observational cohort study
Background: Cohorts of severely ill patients with COVID-19 have been described in several countries around the globe, but to date there…
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PLOS ONE Coagulation profile of COVID-19 patients admitted to the ICU: An exploratory study
Background: Coagulation abnormalities in COVID-19 patients have not been addressed in depth. Objective: To perform a longitudinal…
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PLOS ONE Characteristics, comorbidities and survival analysis of young adults hospitalized with COVID-19 in New York City
This study reviewed 395 young adults, 18–35 year-old, admitted for COVID-19 to one of the eleven hospitals in New York City public health…
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PLOS ONE Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients
Background: The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its…
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PLOS ONE Correlation between hospitalized patients’ demographics, symptoms, comorbidities, and COVID-19 pandemic in Bahia, Brazil
In this paper, we provide a retrospective cohort study with patients that have been hospitalized for general or intensive care unit…
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PLOS ONE Safe contact tracing for COVID-19: A method without privacy breach using functional encryption techniques based-on spatio-temporal trajectory data
The COVID-19 pandemic has spread all over the globe. In the absence of a vaccine, a small number of countries have managed to control the…
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PLOS ONE Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection
Background: Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and…
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PLOS ONE Behavioral preventive measures and the use of medicines and herbal products among the public in response to Covid-19 in Bangladesh: A cross-sectional study
The present study was conducted to assess the behavioral preventive measures and the use of medicines and herbal foods/products among the…
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PLOS ONE Universal screening for SARS-CoV-2 infection among pregnant women at Elmhurst Hospital Center, Queens, New York
Background: Universal screening for SARS-CoV-2 infection on Labor and Delivery (L&D) units is a critical strategy to manage patient and…
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PLOS ONE Can the detection dog alert on COVID-19 positive persons by sniffing axillary sweat samples? A proof-of-concept study
The aim of this proof-of-concept study was to evaluate if trained dogs could discriminate between sweat samples from symptomatic COVID-19…
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PLOS ONE Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis
Background: Efficacy and safety of treatments for hospitalized COVID-19 are uncertain. We systematically reviewed efficacy and safety of…
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PLOS ONE Analyzing changes in respiratory rate to predict the risk of COVID-19 infection
COVID-19, the disease caused by the SARS-CoV-2 virus, can cause shortness of breath, lung damage, and impaired respiratory function.…
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PLOS ONE COVID-19 hospitalizations in Brazil’s Unified Health System (SUS)
Objective: To study the profile of hospitalizations due to COVID-19 in the Unified Health System (SUS) in Brazil and to identify factors…
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PLOS ONE Epidemiological profile of SARS-CoV-2 among selected regions in Ghana: A cross-sectional retrospective study
Background: Global cases of COVID-19 continue to rise, causing havoc to several economies. So far, Ghana has recorded 48,643 confirmed…
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PLOS ONE Impact of chronic liver disease upon admission on COVID-19 in-hospital mortality: Findings from COVOCA study
Background: Italy has been the first Western country to be heavily affected by the spread of SARS-COV-2 infection and among the pioneers of…
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PLOS ONE The local stability of a modified multi-strain SIR model for emerging viral strains
We study a novel multi-strain SIR epidemic model with selective immunity by vaccination. A newer strain is made to emerge in the…
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PLOS ONE Transmissibility of COVID-19 depends on the viral load around onset in adult and symptomatic patients
Objective: To investigate the relationship between viral load and secondary transmission in novel coronavirus disease 2019 (COVID-19).…
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PLOS ONE Severe acute kidney injury in COVID-19 patients is associated with in-hospital mortality
Although the lungs are major targets for COVID-19 invasion, other organs—such as the kidneys—are also affected. However, the renal…
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PLOS ONE COVID-19 mortality risk assessment: An international multi-center study
Timely identification of COVID-19 patients at high risk of mortality can significantly improve patient management and resource allocation…
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PLOS ONE COVID-MATCH65—A prospectively derived clinical decision rule for severe acute respiratory syndrome coronavirus 2
Objectives: We report on the key clinical predictors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and present…
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PLOS ONE Comparison of COVID-19 infections among healthcare workers and non-healthcare workers
Objectives: Healthcare workers face distinct occupational challenges that affect their personal health, especially during a pandemic. In…
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PLOS ONE On the authenticity of COVID-19 case figures
In this article, we study the applicability of Benford’s law and Zipf’s law to national COVID-19 case figures with the aim of establishing…
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PLOS ONE Community interventions in Low—And Middle-Income Countries to inform COVID-19 control implementation decisions in Kenya: A rapid systematic review
Globally, public health measures like face masks, hand hygiene and maintaining social distancing have been implemented to delay and reduce…
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PLOS Neglected Tropical Diseases Risk assessment and evaluation of China’s policy to prevent COVID-19 cases imported by plane
As of October 5, 2020, China has reported 2,921 cases imported from overseas. Assessing the effectiveness of China's current policies on…
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PLOS ONE Estimating individual risks of COVID-19-associated hospitalization and death using publicly available data
We describe a method to estimate individual risks of hospitalization and death attributable to non-household and household transmission of…
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PLOS ONE Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patients
Introduction: Progression of COVID-19 to severe disease and death is insufficiently understood. Objective: Summarize the prevalence of risk…
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PLOS ONE Initial estimates of COVID-19 infections in hospital workers in the United States during the first wave of pandemic
Objective: We estimated the number of hospital workers in the United States (US) that might be infected or die during the COVID-19 pandemic…
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PLOS ONE Comparison of the clinical manifestations between different age groups of patients with overseas imported COVID-19
The current study investigated the clinical manifestations and outcomes of different age groups of patients with overseas imported…
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PLOS ONE The lower COVID-19 related mortality and incidence rates in Eastern European countries are associated with delayed start of community circulation
Background: The purpose of this analysis was to assess the variations in COVID-19 related mortality in relation to the time differences in…
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PLOS ONE Principal component analysis of coronaviruses reveals their diversity and seasonal and pandemic potential
Coronaviruses and influenza viruses have similarities and differences. In order to comprehensively compare them, their genome sequencing…
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PLOS ONE Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19
Introduction: Greece is a country with limited spread of SARS-CoV-2 and cumulative infection attack rate of 0.12% (95% CI 0.06–0.26).…
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PLOS ONE Retinal changes in COVID-19 hospitalized cases
The main objective of this study was to evaluate the retinas of severely or critically ill COVID-19 patients during their hospital stay,…
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PLOS ONE Epidemiology, outcomes, and the use of intensive care unit resources of critically ill patients diagnosed with COVID-19 in Sao Paulo, Brazil: A cohort study
Background: The coronavirus disease (COVID-19) pandemic has brought significant challenges worldwide, with high mortality, increased use of…
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PLOS ONE Characteristics associated with COVID-19 or other respiratory viruses’ infections at a single-center emergency department
Background: Rapid identification of patients with high suspicion of COVID-19 will become a challenge with the co-circulation of multiple…
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PLOS ONE A multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with mild to moderate coronavirus disease 2019 (COVID-19)
Objective: In this study, we evaluated the efficacy of hydroxychloroquine (HCQ) against coronavirus disease 2019 (COVID-19) via a…
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PLOS ONE In silico immune infiltration profiling combined with functional enrichment analysis reveals a potential role for naïve B cells as a trigger for severe immune responses in the lungs of COVID-19 patients
COVID-19, caused by SARS-CoV-2, has rapidly spread to more than 160 countries worldwide since 2020. Despite tremendous efforts and…
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PLOS ONE Early predictive factors of progression from severe type to critical ill type in patients with Coronavirus Disease 2019: A retrospective cohort study
Background: The current worldwide pandemic of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, and…
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PLOS ONE Core warming of coronavirus disease 2019 (COVID-19) patients undergoing mechanical ventilation—A protocol for a randomized controlled pilot study
Background: Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is spreading rapidly across the globe, with little proven…
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PLOS Neglected Tropical Diseases SARS-CoV-2 lineage B.6 was the major contributor to early pandemic transmission in Malaysia
Malaysia had 10,219 confirmed cases of COVID-19 as of September 20, 2020. About 33% were associated with a Tablighi Jamaat religious mass…
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PLOS ONE Study on SARS-CoV-2 transmission and the effects of control measures in China
Objective: To reconstruct the transmission trajectory of SARS-CoV-2 and analyze the effects of control measures in China. Methods: Python…
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PLOS ONE Risk factors for predicting mortality of COVID-19 patients: A systematic review and meta-analysis
Background: Early and accurate prognosis prediction of the patients was urgently warranted due to the widespread popularity of COVID-19. We…
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PLOS ONE Characterisation of 22445 patients attending UK emergency departments with suspected COVID-19 infection: Observational cohort study
Background: Hospital emergency departments play a crucial role in the initial assessment and management of suspected COVID-19 infection.…
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PLOS ONE Biodistribution and serologic response in SARS-CoV-2 induced ARDS: A cohort study
Background: The viral load and tissue distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain important…
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PLOS ONE Deep-learning algorithms for the interpretation of chest radiographs to aid in the triage of COVID-19 patients: A multicenter retrospective study
The recent medical applications of deep-learning (DL) algorithms have demonstrated their clinical efficacy in improving speed and accuracy…
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PLOS ONE Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19
Purpose: In the management of COVID-19, knowledge is lacking on the frequency of secondary bacterial infections and on how empirical…
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PLOS ONE Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure
Purpose: The outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine…
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PLOS ONE Clinical characteristics and online mental health care of asymptomatic or mildly symptomatic patients with coronavirus disease 2019
Comparing to data in patients with severe coronavirus diseases 2019 (COVID-19), there are few studies on the prevalence anxiety and/or…
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PLOS ONE Diagnostic performance of chest computed tomography during the epidemic wave of COVID-19 varied as a function of time since the beginning of the confinement in France
Objective: To evaluate the diagnostic performance of the initial chest CT to diagnose COVID-19 related pneumonia in a French population of…
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PLOS ONE Comorbidity and clinical factors associated with COVID-19 critical illness and mortality at a large public hospital in New York City in the early phase of the pandemic (March-April 2020)
Background: Despite evidence of socio-demographic disparities in outcomes of COVID-19, little is known about characteristics and clinical…
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PLOS ONE ICU admissions and in-hospital deaths linked to COVID-19 in the Paris region are correlated with previously observed ambient temperature
The purpose of this ecological study was to explore the association of weather with severity indicators of coronavirus disease 2019…
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PLOS ONE Effectiveness of infection-containment measures on SARS-CoV-2 seroprevalence and circulation from May to July 2020, in Milan, Italy
Objective: Through a hospital-based SARS-CoV-2 molecular and serological screening, we evaluated the effectiveness of two months of…
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PLOS ONE Clinical characteristics of coronavirus disease 2019 (COVID-19) patients in Kuwait
This is a retrospective single-center study of 417 consecutive patients with coronavirus disease 2019 (COVID-19) admitted to Jaber…
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PLOS ONE C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19
Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease…
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PLOS ONE Performance of serum apolipoprotein-A1 as a sentinel of Covid-19
Background: Since 1920, a decrease in serum cholesterol has been identified as a marker of severe pneumonia. We have assessed the…
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PLOS ONE Antibody profiling and prevalence in US patients during the SARS-CoV2 pandemic
Background: Antibody diagnostics play an important role in disease detection and can potentially aid in monitoring of the immune responses…
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PLOS ONE Computed tomography characterization and outcome evaluation of COVID-19 pneumonia complicated by venous thromboembolism
Background: COVID-19 is frequently complicated by venous thromboembolism (VTE). Computed tomography (CT) of the chest—primarily usually…
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PLOS Neglected Tropical Diseases Spatial analysis of COVID-19 spread in Iran: Insights into geographical and structural transmission determinants at a province level
The Islamic Republic of Iran reported its first COVID-19 cases by 19th February 2020, since then it has become one of the most affected…
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PLOS ONE Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study
The outbreak of SARS-CoV-2 began in December 2019 and rapidly became a pandemic. The present study investigated the significance of…
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PLOS ONE EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2
Due to the challenges for developing vaccines in devastating pandemic situations of severe acute respiratory syndrome coronavirus 2…
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PLOS ONE Early indicators of intensive care unit bed requirement during the COVID-19 epidemic: A retrospective study in Ile-de-France region, France
The aim of our retrospective study was to evaluate the earliest COVID19-related signal to anticipate requirements of intensive care unit…
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PLOS ONE Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis
Background: Understanding the factors associated with disease severity and mortality in Coronavirus disease (COVID-19) is imperative to…
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PLOS ONE Overweight/obesity as the potentially most important lifestyle factor associated with signs of pneumonia in COVID-19
Objective: The occurrence of pneumonia separates severe cases of COVID-19 from the majority of cases with mild disease. However, the…
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PLOS ONE Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review
Background and purpose: The objective of our systematic review is to identify prognostic factors that may be used in decision-making…
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PLOS ONE Clinical, regional, and genetic characteristics of Covid-19 patients from UK Biobank
Background: Coronavirus disease 2019 (Covid-19) has rapidly infected millions of people worldwide. Recent studies suggest that racial…
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PLOS ONE An efficient mixture of deep and machine learning models for COVID-19 diagnosis in chest X-ray images
A newly emerged coronavirus (COVID-19) seriously threatens human life and health worldwide. In coping and fighting against COVID-19, the…
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PLOS ONE Incidence and risk factors of kidney impairment on patients with COVID-19: A meta-analysis of 10180 patients
Background: The novel coronavirus is pandemic around the world. Several researchers have given the evidence of impacts of COVID-19 on the…
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PLOS ONE Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study
Background: This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital. Methods: This retrospective…
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PLOS Biology Superspreading events in the transmission dynamics of SARS-CoV-2: Opportunities for interventions and control
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of the Coronavirus Disease 2019 (COVID-19) disease,…
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PLOS ONE Repurposing therapeutics for COVID-19: Rapid prediction of commercially available drugs through machine learning and docking
Background: The outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus has spread rapidly around the globe…
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PLOS ONE Machine learning in predicting respiratory failure in patients with COVID-19 pneumonia—Challenges, strengths, and opportunities in a global health emergency
Aims: The aim of this study was to estimate a 48 hour prediction of moderate to severe respiratory failure, requiring mechanical…
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PLOS ONE Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020
Background: Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan,…
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PLOS ONE SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study
Serological surveys have been conducted to establish prevalence for COVID-19 antibodies in various cohorts and communities, reporting a…
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PLOS ONE Analyzing inter-reader variability affecting deep ensemble learning for COVID-19 detection in chest radiographs
Data-driven deep learning (DL) methods using convolutional neural networks (CNNs) demonstrate promising performance in natural image…
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PLOS ONE COVID-19 in-hospital mortality and mode of death in a dynamic and non-restricted tertiary care model in Germany
Background: Reported mortality of hospitalised Coronavirus Disease-2019 (COVID-19) patients varies substantially, particularly in…
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PLOS ONE Electronic health record analysis identifies kidney disease as the leading risk factor for hospitalization in confirmed COVID-19 patients
Background: Empirical data on conditions that increase risk of coronavirus disease 2019 (COVID-19) progression are needed to identify high…
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PLOS ONE Unmet clinical needs for COVID-19 tests in UK health and social care settings
There is an urgent requirement to identify which clinical settings are in most need of COVID-19 tests and the priority role(s) for tests…
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PLOS ONE Reproductive number of coronavirus: A systematic review and meta-analysis based on global level evidence
Background: The coronavirus (SARS-COV-2) is now a global concern because of its higher transmission capacity and associated adverse…
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PLOS ONE Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving…
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PLOS ONE Development and validation of a 30-day mortality index based on pre-existing medical administrative data from 13,323 COVID-19 patients: The Veterans Health Administration COVID-19 (VACO) Index
Background: Available COVID-19 mortality indices are limited to acute inpatient data. Using nationwide medical administrative data…
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PLOS Biology Monitor for COVID-19 vaccine resistance evolution during clinical trials
Although less common than the evolution of antimicrobial drug resistance, vaccine resistance can and has evolved. How likely is it that…
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PLOS Neglected Tropical Diseases COVID-19 unfolding filariasis: The first case of SARS-CoV-2 and Wuchereria bancrofti coinfection
With the evolution of the Coronavirus Disease 2019 (COVID-19) pandemic, the number of patients brought to medical attention has increased.…
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PLOS Neglected Tropical Diseases Modeling the stability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on skin, currency, and clothing
A new coronavirus (SARS-CoV-2) emerged in the winter of 2019 in Wuhan, China, and rapidly spread around the world. The extent and…
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PLOS ONE Comparative effectiveness and safety of antiviral agents for patients with COVID-19: Protocol for a systematic review and individual-patient data network meta-analysis
Background: A recent cluster of pneumonia cases in Wuhan, China, has been caused by severe acute respiratory syndrome coronavirus 2…
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PLOS ONE Human mobility trends during the early stage of the COVID-19 pandemic in the United States
In March of this year, COVID-19 was declared a pandemic, and it continues to threaten public health. This global health crisis imposes…
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PLOS ONE Projected impact of COVID-19 mitigation strategies on hospital services in the Mexico City Metropolitan Area
Evidence-based models may assist Mexican government officials and health authorities in determining the safest plans to respond to the…
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PLOS ONE Modelling the initial epidemic trends of COVID-19 in Italy, Spain, Germany, and France
The Coronavirus Disease 2019 (COVID-19) has fast spread to over 200 countries and regions worldwide since its outbreak, while in March,…
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PLOS ONE Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection
Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it is unknown if COVID-19 results in…
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PLOS ONE Prevalence of SARS-CoV-2 among high-risk populations in Lomé (Togo) in 2020
Background: In December 2019, the COVID-19 outbreak began in China and quickly spread throughout the world and was reclassified as a…
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PLOS Biology A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led…
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PLOS ONE Beyond the peak: A deterministic compartment model for exploring the Covid-19 evolution in Italy
Novel Covid-19 has had a huge impact on the world’s population since December 2019. The very rapid spreading of the virus worldwide, with…
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PLOS ONE Pattern of COVID-19 in Sichuan province, China: A descriptive epidemiological analysis
This study described the epidemiology of 487 confirmed coronavirus disease 2019 (COVID-19) cases in Sichuan province of China, and aimed…
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PLOS ONE A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study
The COVID-19 is rapidly scattering worldwide, and the number of cases in the Eastern Mediterranean Region is rising. Thus, there is a need…
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PLOS ONE The impact of individual lifestyle and status on the acquisition of COVID-19: A case—Control study
Background: Coronavirus disease 2019 (COVID-19) has spread to the world. Whether there is an association between lifestyle behaviors and…
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PLOS ONE Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants
Introduction: Older people have been reported to be at higher risk of COVID-19 mortality. This study explored the factors mediating this…
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PLOS ONE Air and surface measurements of SARS-CoV-2 inside a bus during normal operation
Transmission pathways of SARS-CoV-2 are aerosol, droplet and touching infected material. The diffusion of the virus contagion among people…
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PLOS ONE A national study to assess pharmacists’ preparedness against COVID-19 during its rapid rise period in Pakistan
To evaluate the pharmacist’s preparedness against the COVID-19 during its rapid rise period in Pakistan, an online cross-sectional study…
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PLOS ONE Ocular surface manifestations of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis
Purpose: This study was performed to determine the occurrence of ocular surface manifestations in patients diagnosed with coronavirus…
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PLOS ONE Monitoring life expectancy levels during the COVID-19 pandemic: Example of the unequal impact of the first wave on Spanish regions
Background: To provide an interpretable summary of the impact on mortality of the COVID-19 pandemic we estimate weekly and annual life…
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PLOS ONE Boosting test-efficiency by pooled testing for SARS-CoV-2—Formula for optimal pool size
In the current COVID19 crisis many national healthcare systems are confronted with an acute shortage of tests for confirming SARS-CoV-2…
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PLOS ONE Clinical characteristics of re-positive COVID-19 patients in Huangshi, China: A retrospective cohort study
A cluster of patients with coronavirus disease 2019 (COVID-19) underwent repeated positive severe acute respiratory syndrome coronavirus 2…
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PLOS ONE Liver injury with COVID-19 based on gastrointestinal symptoms and pneumonia severity
Background/Aim: The coronavirus disease 2019 (COVID-19) had become a big threat worldwide. Liver injury is not uncommon in patients with…
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PLOS ONE Predictors of in-hospital COVID-19 mortality: A comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions
Objective: Risk factors for in-hospital mortality in confirmed COVID-19 patients have been summarized in numerous meta-analyses, but it is…
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PLOS ONE Low-dose chest CT for diagnosing and assessing the extent of lung involvement of SARS-CoV-2 pneumonia using a semi quantitative score
Objectives: The purpose is to assess the ability of low-dose CT (LDCT) to determine lung involvement in SARS-CoV-2 pneumonia and to…
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PLOS ONE Characteristics and outcomes of hospitalised patients with acute kidney injury and COVID-19
Introduction: COVID-19 has spread globally to now be considered a pandemic by the World Health Organisation. Initially patients appeared to…
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PLOS ONE COVID-19 gender susceptibility and outcomes: A systematic review
Background: Epidemiological differences between men and women have been reported with regards to sepsis, influenza and severe coronavirus…
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PLOS ONE Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: A systematic review and meta-analysis
Background: The study objective was to conduct a systematic review and meta-analysis on the proportion of asymptomatic infection among…
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PLOS ONE Clinical impact of monocyte distribution width and neutrophil-to-lymphocyte ratio for distinguishing COVID-19 and influenza from other upper respiratory tract infections: A pilot study
The coronavirus disease 2019 (COVID-19) has become a pandemic. Rapidly distinguishing COVID-19 from other respiratory infections is a…
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PLOS ONE Performance of nucleocapsid and spike-based SARS-CoV-2 serologic assays
There is an urgent need for an accurate antibody test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We have developed…
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PLOS Medicine Acute kidney injury associated with COVID-19: A retrospective cohort study
Background: Initial reports indicate a high incidence of acute kidney injury (AKI) in Coronavirus Disease 2019 (COVID-19), but more data…
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PLOS ONE Effect of blood analysis and immune function on the prognosis of patients with COVID-19
Introduction: This retrospective study investigated the implications of changes in blood parameters and cellular immune function in…
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PLOS ONE Silent disease and loss of taste and smell are common manifestations of SARS-COV-2 infection in a quarantine facility: Saudi Arabia
Objectives: In this study, we aimed to study the clinical presentations, and viral clearance of SARS-COV-2 positive quarantined…
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PLOS Pathogens On the whereabouts of SARS-CoV-2 in the human body: A systematic review
Since SARS-CoV-2 appeared in the human population, the scientific community has scrambled to gather as much information as possible to…
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PLOS Neglected Tropical Diseases SARS-CoV-2 in the Amazon region: A harbinger of doom for Amerindians
As the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic continues to expand, healthcare resources globally have been…
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PLOS Pathogens “Trained immunity” from Mycobacterium spp. exposure or BCG vaccination and COVID-19 outcomes
Protective variables for Coronavirus Disease 2019 (COVID-19) are unknown. “Trained immunity” of the populace as a result of Bacille…
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PLOS ONE The values of coagulation function in COVID-19 patients
Objective: To investigate the blood coagulation function in COVID-19 patients, and the correlation between coagulopathy and disease…
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PLOS ONE Assessing COVID-19 risk, vulnerability and infection prevalence in communities
Background: The spread of coronavirus in the United States with nearly five and half million confirmed cases and over 170,000 deaths has…
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PLOS ONE The first wave of COVID-19 in Israel—Initial analysis of publicly available data
The first case of COVID-19 was confirmed in Israel on February 21, 2020. Within approximately 30 days, the total number of confirmed cases…
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PLOS ONE SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts, Thailand, April-June 2020
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although Thailand has…
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PLOS ONE On the temporal spreading of the SARS-CoV-2
The behaviour of SARS-CoV-2 virus is certainly one of the most challenging in contemporary world. Although the mathematical modelling of…
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PLOS ONE Facilitators and barriers to engagement with contact tracing during infectious disease outbreaks: A rapid review of the evidence
Background: Until a vaccine is developed, a test, trace and isolate strategy is the most effective method of controlling the COVID-19…
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PLOS ONE Estimation of the percentages of undiagnosed patients of the novel coronavirus (SARS-CoV-2) infection in Hokkaido, Japan by using birth-death process with recursive full tracing
Estimating the percentages of undiagnosed and asymptomatic patients is essential for controlling the outbreak of SARS-CoV-2, and for…
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PLOS ONE Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2
Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of…
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PLOS ONE COVID-19 outbreak in long-term care facilities from Spain. Many lessons to learn
Background/Objectives: To analyze mortality, costs, residents and personnel characteristics, in six long-term care facilities (LTCF) during…
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PLOS ONE Evaluation of SARS-CoV-2 IgG antibody response in PCR positive patients: Comparison of nine tests in relation to clinical data
SARS-CoV-2 antibody tests are available in various formats, detecting different viral target proteins and antibody subclasses. The…
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PLOS ONE Cancer inpatients with COVID-19: A report from the Brazilian National Cancer Institute
Objective: This study aimed to describe the demographic and clinical characteristics of cancer inpatients with COVID-19 exploring clinical…
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PLOS ONE Surgery for non-Covid-19 patients during the pandemic
Background: In the early phase of the Covid-19 pandemic, mainly data related to the burden of care required by infected patients were…
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PLOS ONE Prevalence of underlying diseases in died cases of COVID-19: A systematic review and meta-analysis
Introduction: Underlying disease have a critical role in vulnerability of populations for a greater morbidity and mortality when they…
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PLOS Neglected Tropical Diseases Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study
Modelling, Forecasting, and Surveillance
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PLOS Computational Biology Predictions of COVID-19 dynamics in the UK: Short-term forecasting and analysis of potential exit strategies
Efforts to suppress transmission of SARS-CoV-2 in the UK have seen non-pharmaceutical interventions being invoked. The most severe…
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PLOS ONE Lessons from movement ecology for the return to work: Modeling contacts and the spread of COVID-19
Human behavior (movement, social contacts) plays a central role in the spread of pathogens like SARS-CoV-2. The rapid spread of SARS-CoV-2…
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PLOS ONE Forecasting hospital demand in metropolitan areas during the current COVID-19 pandemic and estimates of lockdown-induced 2nd waves
We present a forecasting model aim to predict hospital occupancy in metropolitan areas during the current COVID-19 pandemic. Our SEIRD…
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PLOS Computational Biology Modeling the structure of the frameshift-stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformers
The coronavirus causing the COVID-19 pandemic, SARS-CoV-2, uses −1 programmed ribosomal frameshifting (−1 PRF) to control the relative…
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PLOS ONE Model-based forecasting for Canadian COVID-19 data
Background: Since March 11, 2020 when the World Health Organization (WHO) declared the COVID-19 pandemic, the number of infected cases, the…
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PLOS ONE Modeling the initial phase of SARS-CoV-2 deposition in the respiratory tract mimicked by the 11C radionuclide
The knowledge on the deposition and retention of the viral particle of SARS-CoV-2 in the respiratory tract during the very initial intake…
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PLOS ONE Impact of altitude on COVID-19 infection and death in the United States: A modeling and observational study
Background: COVID-19, the disease caused by SARS-CoV-2, has caused a pandemic, sparing few regions. However, limited reports suggest…
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PLOS ONE Predicting in-hospital mortality from Coronavirus Disease 2019: A simple validated app for clinical use
Backgrounds: Validated tools for predicting individual in-hospital mortality of COVID-19 are lacking. We aimed to develop and to validate a…
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PLOS ONE Tracking R of COVID-19: A new real-time estimation using the Kalman filter
We develop a new method for estimating the effective reproduction number of an infectious disease (R) and apply it to track the dynamics…
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PLOS ONE COVID-19: Short-term forecast of ICU beds in times of crisis
By early May 2020, the number of new COVID-19 infections started to increase rapidly in Chile, threatening the ability of health services…
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PLOS ONE Prediction of the COVID-19 epidemic trends based on SEIR and AI models
In December 2019, the outbreak of a new coronavirus-caused pneumonia (COVID-19) in Wuhan attracted close attention in China and the world.…
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PLOS ONE Robust estimation of diagnostic rate and real incidence of COVID-19 for European policymakers
Policymakers need clear, fast assessment of the real spread of the COVID-19 epidemic in each of their respective countries. Standard…
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PLOS ONE The use of health geography modeling to understand early dispersion of COVID-19 in São Paulo, Brazil
Public health policies to contain the spread of COVID-19 rely mainly on non-pharmacological measures. Those measures, especially social…
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PLOS ONE A scientometric overview of CORD-19
As the COVID-19 pandemic unfolds, researchers from all disciplines are coming together and contributing their expertise. CORD-19, a…
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PLOS ONE Forecasting COVID-19 confirmed cases, deaths and recoveries: Revisiting established time series modeling through novel applications for the USA and Italy
The novel coronavirus (COVID-19) is an emergent disease that initially had no historical data to guide scientists on predicting/…
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PLOS ONE Predicting health behavior in response to the coronavirus disease (COVID-19): Worldwide survey results from early March 2020
The current pandemic outbreak of the novel COVID-19, which originated from Wuhan in China in late 2019, has eventually spread to six…
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PLOS ONE Relaxation of social distancing restrictions: Model estimated impact on COVID-19 epidemic in Manitoba, Canada
Objectives: The unprecedented worldwide social distancing response to COVID-19 resulted in a quick reversal of escalating case numbers.…
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PLOS ONE Simple predictive models identify patients with COVID-19 pneumonia and poor prognosis
Background and aims: Identification of SARS-CoV-2-infected patients at high-risk of poor prognosis is crucial. We aimed to establish…
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PLOS ONE Comparison of in-hospital mortality risk prediction models from COVID-19
Objective: Our objective is to compare the predictive accuracy of four recently established outcome models of patients hospitalized with…
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PLOS ONE Spreading of COVID-19: Density matters
Physical distancing has been argued as one of the effective means to combat the spread of COVID-19 before a vaccine or therapeutic drug…
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PLOS ONE Real-time neural network based predictor for cov19 virus spread
Since the epidemic outbreak in early months of 2020 the spread of COVID-19 has grown rapidly in most countries and regions across the…
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PLOS ONE Estimating the herd immunity threshold by accounting for the hidden asymptomatics using a COVID-19 specific model
A quantitative COVID-19 model that incorporates hidden asymptomatic patients is developed, and an analytic solution in parametric form is…
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PLOS Computational Biology Empirical model for short-time prediction of COVID-19 spreading
The appearance and fast spreading of Covid-19 took the international community by surprise. Collaboration between researchers, public…
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PLOS ONE Development and external validation of a prognostic tool for COVID-19 critical disease
Background: The rapid spread of coronavirus disease 2019 (COVID-19) revealed significant constraints in critical care capacity. In…
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PLOS Computational Biology Quantifying the impact of COVID-19 control measures using a Bayesian model of physical distancing
Extensive non-pharmaceutical and physical distancing measures are currently the primary interventions against coronavirus disease 2019…
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PLOS ONE Estimating the real burden of disease under a pandemic situation: The SARS-CoV2 case
The present paper introduces a new model used to study and analyse the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)…
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PLOS ONE Lockdown, relaxation, and acme period in COVID-19: A study of disease dynamics in Hermosillo, Sonora, Mexico
Lockdown and social distancing measures have been implemented for many countries to mitigate the impacts of the COVID-19 pandemic and…
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PLOS ONE COVID-19 healthcare demand projections: Arizona
Beginning in March 2020, the United States emerged as the global epicenter for COVID-19 cases with little to guide policy response in the…
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PLOS ONE Forecasting COVID-19 in Pakistan
Objectives: Forecasting epidemics like COVID-19 is of crucial importance, it will not only help the governments but also, the medical…
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PLOS ONE Modeling and interpreting the COVID-19 intervention strategy of China: A human mobility view
The Coronavirus Disease 2019 (COVID-19) has proved a globally prevalent outbreak since December 2019. As a focused country to alleviate…
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PLOS ONE Testing IgG antibodies against the RBD of SARS-CoV-2 is sufficient and necessary for COVID-19 diagnosis
The COVID-19 pandemic and the fast global spread of the disease resulted in unprecedented decline in world trade and travel. A critical…
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PLOS ONE Kemeny-based testing for COVID-19
Testing, tracking and tracing abilities have been identified as pivotal in helping countries to safely reopen activities after the first…
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PLOS ONE Clinical and molecular characterization of COVID-19 hospitalized patients
Clinical and molecular characterization by Whole Exome Sequencing (WES) is reported in 35 COVID-19 patients attending the University…
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PLOS ONE Analysis of the SARS-CoV-2 epidemic in Italy: The role of local and interventional factors in the control of the epidemic
Containment measures have been applied in several countries in order to limit the diffusion of the SARS-CoV-2 epidemic. The scope of this…
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PLOS Pathogens Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression
The COVID-19 has emerged as an epidemic, causing severe pneumonia with a high infection rate globally. To better understand the…
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PLOS ONE Simulation-free estimation of an individual-based SEIR model for evaluating nonpharmaceutical interventions with an application to COVID-19 in the District of Columbia
The ongoing COVID-19 pandemic has overwhelmingly demonstrated the need to accurately evaluate the effects of implementing new or altering…
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PLOS ONE Forecasting imported COVID-19 cases in South Korea using mobile roaming data
As the number of global coronavirus disease (COVID-19) cases increases, the number of imported cases is gradually rising. Furthermore,…
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PLOS ONE Effect of mitigation measures on the spreading of COVID-19 in hard-hit states in the U.S.
State government-mandated social distancing measures have helped to slow the growth of the COVID-19 pandemic in the United States. Many of…
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PLOS ONE Tracing day-zero and forecasting the COVID-19 outbreak in Lombardy, Italy: A compartmental modelling and numerical optimization approach
Introduction: Italy became the second epicenter of the novel coronavirus disease 2019 (COVID-19) pandemic after China, surpassing by far…
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PLOS ONE Modeling the load of SARS-CoV-2 virus in human expelled particles during coughing and speaking
Particle size is an essential factor when considering the fate and transport of virus-containing droplets expelled by human, because it…
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PLOS ONE A social network model of COVID-19
I construct a dynamic social-network model of the COVID-19 epidemic which embeds the SIR epidemiological model onto a graph of…
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PLOS ONE A discrete-time-evolution model to forecast progress of Covid-19 outbreak
Here we present a discrete-time-evolution model with one day interval to forecast the propagation of Covid-19. The proposed model can be…
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PLOS ONE The first 2 months of the SARS-CoV-2 epidemic in Yemen: Analysis of the surveillance data
Introduction: Yemen was one of the last countries in the world to declare the first case of the pandemic, on 10 April 2020. Fear and…
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PLOS ONE Monitoring physical distancing for crowd management: Real-time trajectory and group analysis
Physical distancing, as a measure to contain the spreading of Covid-19, is defining a “new normal”. Unless belonging to a family,…
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PLOS ONE Country-level pandemic risk and preparedness classification based on COVID-19 data: A machine learning approach
In this work we present a three-stage Machine Learning strategy to country-level risk classification based on countries that are reporting…
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PLOS ONE Modeling and prediction of the 2019 coronavirus disease spreading in China incorporating human migration data
This study integrates the daily intercity migration data with the classic Susceptible-Exposed-Infected-Removed (SEIR) model to construct a…
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PLOS ONE Assessing concerns for the economic consequence of the COVID-19 response and mental health problems associated with economic vulnerability and negative economic shock in Italy, Spain, and the United Kingdom
Many different countries have been under lockdown or extreme social distancing measures to control the spread of COVID-19. The potentially…
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PLOS ONE A mathematical model of COVID-19 transmission in a tertiary hospital and assessment of the effects of different intervention strategies
Novel coronavirus (named SARS-CoV-2) can spread widely in confined settings including hospitals, cruise ships, prisons, and places of…
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PLOS ONE Game analysis on the evolution of COVID-19 epidemic under the prevention and control measures of the government
In this paper, the interaction strategies and the evolutionary game analysis of the actions taken by the government and the public in the…
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PLOS ONE Modeling latent infection transmissions through biosocial stochastic dynamics
The events of the recent SARS-CoV-2 epidemics have shown the importance of social factors, especially given the large number of…
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PLOS ONE The impact of lockdown enforcement during the SARSCoV-2 pandemic on the timing of presentation and early outcomes of patients with ST-elevation myocardial infarction
Introduction: Early reports described decreased admissions for acute cardiovascular events during the SarsCoV-2 pandemic. We aimed to…
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PLOS Neglected Tropical Diseases Identifying the outbreak signal of COVID-19 before the response of the traditional disease monitoring system