Biology & Life Sciences

COVID-19 pandemic (2019-21)

Updated June 17, 2021 Curated Collections

This Collection of articles highlights all content published across the PLOS journals relating to the COVID-19 pandemic in 2019-21. PLOS is committed to disseminating research as quickly as possible, particularly in public health emergencies. All articles published in any PLOS journal are Open Access free of charge to all readers.

Image Credit: US NIH/Public domain (CC-0) and Senado Federal/Flickr (CC-BY)

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Clinical Epidemiology and Care

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Fig 2. Forest plot of the prevalence of COVID-19 in ESRD patients with RRT. by Nopsopon et al., CC BY 4.0

PLOS Neglected Tropical Diseases Covid-19 in end-stage renal disease patients with renal replacement therapies: A systematic review and meta-analysis
June 15, 2021 Tanawin Nopsopon, Jathurong Kittrakulrat, Kullaya Takkavatakarn, Thanee Eiamsitrakoon, Talerngsak Kanjanabuch, Krit Pongpirul

Background: The novel coronavirus (COVID-19), caused by SARS-CoV-2, showed various prevalence and case-fatality rates (CFR) among patients…
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Fig 1. Comparison of clinic characteristics of COVID-19 patients in Mild-Moderate and Severe-Critically Severe groups (n = 196). by Luo et al., CC BY 4.0

PLOS ONE The selection of indicators from initial blood routine test results to improve the accuracy of early prediction of COVID-19 severity
June 15, 2021 Jiaqing Luo, Lingyun Zhou, Yunyu Feng, Bo Li, Shujin Guo

The global pandemic of COVID-19 poses a huge threat to the health and lives of people all over the world, and brings unprecedented…
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Fig 1. Sex and age-stratified COVID-19 incidence estimates by region (A, B and C), Peru, 2020. by Ramírez-Soto et al., CC BY 4.0

PLOS ONE Sex differences in the incidence, mortality, and fatality of COVID-19 in Peru
June 14, 2021 Max Carlos Ramírez-Soto, Hugo Arroyo-Hernández, Gutia Ortega-Cáceres

Background: There is a worrying lack of epidemiological data on the sex differential in COVID-19 infection and death rates between the…
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Fig 1. by Borse et al., CC BY 4.0

PLOS ONE Ayurveda botanicals in COVID-19 management: An in silico multi-target approach
June 11, 2021 Swapnil Borse, Manali Joshi, Akash Saggam, Vedika Bhat, Safal Walia, Aniket Marathe, Sneha Sagar, Preeti Chavan-Gautam, Aboli Girme, Lal Hingorani, Girish Tillu

The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there…
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Fig 1. Mortality Trends in COVID-19 admissions. by Coppock et al., CC BY 4.0

PLOS ONE COVID-19 treatment combinations and associations with mortality in a large multi-site healthcare system
June 11, 2021 Dagan Coppock, Michael Baram, Anna Marie Chang, Patricia Henwood, Alan Kubey, Ross Summer, John Zurlo, Michael Li, Bryan Hess

Introduction: During the early months of the COVID-19 pandemic, mortality associated with the disease declined in the United States. The…
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Fig 3. IgG levels in the patients during the three visits. by Alzaabi et al., CC BY 4.0

PLOS ONE Longitudinal changes in IgG levels among COVID-19 recovered patients: A prospective cohort study
June 11, 2021 Ashraf Hassan Alzaabi, Luai A. Ahmed, Abdulla E. Rabooy, Ali Al Zaabi, Mohammed Alkaabi, Falah AlMahmoud, Mai Farouk Hamed, Khalid Omar Bashaeb, Abdul Rahim Bakhsh, Suha Adil, Nadeen Elmajed, Ahmed Nigm Abousalha, Ahmad Kanaan Uwaydah, Khulood Al Mazrouei

Objectives: To quantify SARS-CoV2 IgG antibody titers over time and assess the longevity of the immune response in a multi-ethnic…
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Fig 1. Stability of SARS-CoV-2 RNA in a swab of saliva mixed with eNAT (A) or saliva diluted 1:2 with eNAT (B). by Banik et al., CC BY 4.0

PLOS ONE Inactivation of SARS-CoV-2 virus in saliva using a guanidium based transport medium suitable for RT-PCR diagnostic assays
June 11, 2021 Sukalyani Banik, Kaheerman Saibire, Shraddha Suryavanshi, Glenn Johns, Soumitesh Chakravorty, Robert Kwiatkowski, David Alland, Padmapriya P. Banada

Background: Upper respiratory samples used to test for SARS-CoV-2 virus may be infectious and present a hazard during transport and…
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Fig 1. by Fowler et al., CC BY 4.0

PLOS ONE Stay-at-home orders associate with subsequent decreases in COVID-19 cases and fatalities in the United States
June 10, 2021 James H. Fowler, Seth J. Hill, Remy Levin, Nick Obradovich

Governments issue “stay-at-home” orders to reduce the spread of contagious diseases, but the magnitude of such orders’ effectiveness…
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Fig 1. Different slices of CT scans representing each patients group. by Alves et al., CC BY 4.0

PLOS ONE Automatic algorithm for quantifying lung involvement in patients with chronic obstructive pulmonary disease, infection with SARS-CoV-2, paracoccidioidomycosis and no lung disease patients
June 10, 2021 Allan Felipe Fattori Alves, José Ricardo Arruda Miranda, Fabiano Reis, Abner Alves Oliveira, Sérgio Augusto Santana Souza, Carlos Magno Castelo Branco Fortaleza, Suzana Erico Tanni, José Thiago Souza Castro, Diana Rodrigues Pina

In this work, we aimed to develop an automatic algorithm for the quantification of total volume and lung impairments in four different…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public Domain

PLOS ONE Nurses’ core disaster-response competencies for combating COVID-19—A cross-sectional study
June 10, 2021 Igor Karnjuš, Mirko Prosen, Sabina Ličen

The core competencies in disaster nursing, nurses’ roles in disaster management and the potential barriers are assessed with a view to…
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Fig 1. Stay-at-home measure and number of new infections, Tokyo. by Watanabe and Yabu, CC BY 4.0

PLOS ONE Japan’s voluntary lockdown
June 10, 2021 Tsutomu Watanabe, Tomoyoshi Yabu

Japan’s government has taken a number of measures, including declaring a state of emergency, to combat the spread COVID-19. We examine the…
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Fig 1. Differences between German and Austrian GPs in their evaluation of the pandemic (Austria: n = 900; Germany: n = 1287). by Siebenhofer et al., CC BY 4.0

PLOS ONE COVI-Prim survey: Challenges for Austrian and German general practitioners during initial phase of COVID-19
June 10, 2021 Andrea Siebenhofer, Sebastian Huter, Alexander Avian, Karola Mergenthal, Dagmar Schaffler-Schaden, Ulrike Spary-Kainz, Herbert Bachler, Maria Flamm

Background: Coronavirus disease 2019 (COVID-19) represents a significant challenge to health care systems around the world. A…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public Domain

PLOS ONE Low level SARS-CoV-2 RNA detected in plasma samples from a cohort of Nigerians: Implications for blood transfusion
June 10, 2021 Azuka Patrick Okwuraiwe, Chika Kingsley Onwuamah, Joseph Ojonugwa Shaibu, Samuel Olufemi Amoo, Fehintola Anthonia Ige, Ayorinde Babatunde James, Leona Chika Okoli, Abul-Rahman Ahmed, Jamda Ponmak, Judith O. Sokei, Sulaimon Akanmu, Babatunde Lawal Salako, Rosemary Ajuma Audu

The present global pandemic triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has lingered for over a year in…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public Domain

PLOS ONE Investigation of superspreading COVID-19 outbreak events in meat and poultry processing plants in Germany: A cross-sectional study
June 10, 2021 Roman Pokora, Susan Kutschbach, Matthias Weigl, Detlef Braun, Annegret Epple, Eva Lorenz, Stefan Grund, Juergen Hecht, Helmut Hollich, Peter Rietschel, Frank Schneider, Roland Sohmen, Katherine Taylor, Isabel Dienstbuehl

Since May 2020, several COVID-19 outbreaks have occurred in the German meat industry despite various protective measures, and temperature…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Seroprevalence of anti-SARS-CoV-2 IgG antibodies in the staff of a public school system in the midwestern United States
June 10, 2021 Lilah Lopez, Thao Nguyen, Graham Weber, Katlyn Kleimola, Megan Bereda, Yiling Liu, Emma K. Accorsi, Steven J. Skates, John P. Santa Maria Jr., Kendal R. Smith, Mark Kalinich

Since March 2020, the United States has lost over 580,000 lives to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which…
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Fig 1. Viability of SARS-CoV-2 on stainless steel after exposure to simulated sunlight. by Sloan et al., CC BY 4.0

PLOS ONE Simulated sunlight decreases the viability of SARS-CoV-2 in mucus
June 10, 2021 Angela Sloan, Todd Cutts, Bryan D. Griffin, Samantha Kasloff, Zachary Schiffman, Mable Chan, Jonathan Audet, Anders Leung, Darwyn Kobasa, Derek R. Stein, David Safronetz, Guillaume Poliquin

The novel coronavirus, SARS-CoV-2, has spread into a pandemic since its emergence in Wuhan, China in December of 2019. This has been…
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Fig 1. Variability in SARS-CoV-2 IgG antibody response. by Schaefer et al., CC BY 4.0

PLOS ONE Corona Virus Disease-19 serology, inflammatory markers, hospitalizations, case finding, and aging
June 10, 2021 Ernst J. Schaefer, Latha Dulipsingh, Florence Comite, Jessica Jimison, Martin M. Grajower, Nathan E. Lebowitz, Maxine Lang, Andrew S. Geller, Margaret R. Diffenderfer, Lihong He, Gary Breton, Michael L. Dansinger, Ben Saida, Chong Yuan

Most deaths from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection occur in older subjects. We assessed the utility…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Screening for SARS-CoV-2 by RT-PCR: Saliva or nasopharyngeal swab? Rapid review and meta-analysis
June 10, 2021 Nusaïbah Ibrahimi, Agnès Delaunay-Moisan, Catherine Hill, Gwénaël Le Teuff, Jean-François Rupprecht, Jean-Yves Thuret, Dan Chaltiel, Marie-Claude Potier

Background: Diagnosis of COVID-19 in symptomatic patients and screening of populations for SARS-CoV-2 infection require access to…
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Fig 1. Treatment outcome among patients admitted with COVID-19 in WURH treatment. by Tolossa et al., CC BY 4.0

PLOS ONE Time to recovery from COVID-19 and its predictors among patients admitted to treatment center of Wollega University Referral Hospital (WURH), Western Ethiopia: Survival analysis of retrospective cohort study
June 10, 2021 Tadesse Tolossa, Bizuneh Wakuma, Dejene Seyoum Gebre, Emiru Merdassa Atomssa, Motuma Getachew, Getahun Fetensa, Diriba Ayala, Ebisa Turi

Introduction: Despite its alarming spread throughout the world, no effective drug and vaccine is discovered for COVID-19 so far. According…
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Fig 1. Distribution of treatment modalities over time. by Malhani et al., CC BY 4.0

PLOS ONE Combination of (interferon beta-1b, lopinavir/ritonavir and ribavirin) versus favipiravir in hospitalized patients with non-critical COVID-19: A cohort study
June 10, 2021 Areej A. Malhani, Mushira A. Enani, Fatemeh Saheb Sharif-Askari, Mona R. Alghareeb, Roaa T. Bin-Brikan, Safar A. AlShahrani, Rabih Halwani, Imad M. Tleyjeh

Objectives: Our study aims at comparing the efficacy and safety of IFN-based therapy (lopinavir/ritonavir, ribavirin, and interferon β-1b)…
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Fig 1. Racial discrepancies between NMH 2019 kidney transplant recipients and the SARS-CoV 2 positive kidney transplant recipient cohort. by Nahi et al., CC BY 4.0

PLOS ONE Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience
June 10, 2021 Skylar L. Nahi, Aneesha A. Shetty, Sajal D. Tanna, Joseph R. Leventhal

Background: Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their…
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Fig 1. The numbers of matched nasopharyngeal and saliva samples. by Ota et al., CC BY 4.0

PLOS ONE Detection of SARS-CoV-2 using qRT-PCR in saliva obtained from asymptomatic or mild COVID-19 patients, comparative analysis with matched nasopharyngeal samples
June 10, 2021 Kenji Ota, Katsunori Yanagihara, Daisuke Sasaki, Norihito Kaku, Naoki Uno, Kei Sakamoto, Kosuke Kosai, Taiga Miyazaki, Hiroo Hasegawa, Ayumi Fujita, Masato Tashiro, Takeshi Tanaka, Koichi Izumikawa, Koya Ariyoshi, Hiroshi Mukae, Jiro Yasuda, Kouichi Morita, Shigeru Kohno

Objectives: The accurate detection of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is essential for the diagnosis of…
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Fig 3. Survival curves, regarding the primary outcome, comparing HCQ/AZI and control group. by Saib et al., CC BY 4.0

PLOS ONE Lack of efficacy of hydroxychloroquine and azithromycin in patients hospitalized for COVID-19 pneumonia: A retrospective study
June 9, 2021 Anis Saib, Walid Amara, Pascal Wang, Simon Cattan, Azeddine Dellal, Kais Regaieg, Stephane Nahon, Olivier Nallet, Lee S. Nguyen

Background: Hydroxychloroquine combined with azithromycin (HCQ/AZI) has initially been used against coronavirus disease-2019 (COVID-19). In…
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Fig 1. Generation of SARS-CoV2-SP-pseudotyped lentivirus particles (SCoV-2-SP-PVs). by Ao et al., CC BY 4.0

PLOS ONE Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry
June 9, 2021 Zhujun Ao, Mable Chan, Maggie Jing Ouyang, Titus Abiola Olukitibi, Mona Mahmoudi, Darwyn Kobasa, Xiaojian Yao

Until now, antiviral therapeutic agents are still urgently required for treatment or prevention of SARS-coronavirus 2 (SCoV-2) virus…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study
June 9, 2021 Francisco Purroy, Gloria Arqué

Background: COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of…
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Fig 2. Estimated basic reproduction numbers (R₀) for countries across the globe. by Kong et al., CC BY 4.0

PLOS ONE Social, economic, and environmental factors influencing the basic reproduction number of COVID-19 across countries
June 9, 2021 Jude Dzevela Kong, Edward W. Tekwa, Sarah A. Gignoux-Wolfsohn

Objective: To assess whether the basic reproduction number (R0) of COVID-19 is different across countries and what national-level…
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Fig 2. by Poschenrieder et al., CC BY 4.0

PLOS ONE Severe COVID-19 pneumonia: Perfusion analysis in correlation with pulmonary embolism and vessel enlargement using dual-energy CT data
June 8, 2021 Florian Poschenrieder, Stefanie Meiler, Matthias Lubnow, Florian Zeman, Janine Rennert, Gregor Scharf, Jan Schaible, Christian Stroszczynski, Michael Pfeifer, Okka W. Hamer

Background: Gas exchange in COVID-19 pneumonia is impaired and vessel obstruction has been suspected to cause ventilation-perfusion…
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Fig 1. The global model collects local models updates. by Abdul Salam et al., CC BY 4.0

PLOS ONE COVID-19 detection using federated machine learning
June 8, 2021 Mustafa Abdul Salam, Sanaa Taha, Mohamed Ramadan

The current COVID-19 pandemic threatens human life, health, and productivity. AI plays an essential role in COVID-19 case classification…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Excess mortality by specific causes of deaths in the city of São Paulo, Brazil, during the COVID-19 pandemic
June 7, 2021 Gisele Aparecida Fernandes, Antonio Paulo Nassar Junior, Gulnar Azevedo e Silva, Diego Feriani, Ivan Leonardo Avelino França e Silva, Pedro Caruso, Maria Paula Curado

Background: To investigate the excess of deaths by specific causes, in the first half of 2020 in the city of São Paulo-Brazil, during the…
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Fig 3. Representative case without COVID-19 pneumonia. by Hwang et al., CC BY 4.0

PLOS ONE COVID-19 pneumonia on chest X-rays: Performance of a deep learning-based computer-aided detection system
June 7, 2021 Eui Jin Hwang, Ki Beom Kim, Jin Young Kim, Jae-Kwang Lim, Ju Gang Nam, Hyewon Choi, Hyungjin Kim, Soon Ho Yoon, Jin Mo Goo, Chang Min Park

Chest X-rays (CXRs) can help triage for Coronavirus disease (COVID-19) patients in resource-constrained environments, and a computer-aided…
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Fig 2. Timeline of SARS-CoV-2 R.1 lineage emergence and country-specific percentages of global cases. by Hirotsu and Omata, CC BY 4.0

PLOS Pathogens Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan
June 7, 2021 Yosuke Hirotsu, Masao Omata

We aimed to investigate novel emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages in Japan that harbor variants…
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Fig 2. Marginal effects of temperature (t-14) on Covid-19 fatalities (direct effect with DFE estimates). by Damette et al., CC BY 4.0

PLOS ONE Meteorological factors against COVID-19 and the role of human mobility
June 4, 2021 Olivier Damette, Clément Mathonnat, Stéphane Goutte

In the vein of recent empirical literature, we reassessed the impact of weather factors on Covid-19 daily cases and fatalities in a panel…
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Fig 1. Relative excess mortality among Californians 18–65 years of age, March through November 2020. by Chen et al., CC BY 4.0

PLOS ONE Excess mortality associated with the COVID-19 pandemic among Californians 18–65 years of age, by occupational sector and occupation: March through November 2020
June 4, 2021 Yea-Hung Chen, Maria Glymour, Alicia Riley, John Balmes, Kate Duchowny, Robert Harrison, Ellicott Matthay, Kirsten Bibbins-Domingo

Background: Though SARS-CoV-2 outbreaks have been documented in occupational settings and in-person essential work has been suspected as a…
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Fig 2. Proportions of pooling of secretions and recommendations of oral intake in COVID-19 patients treated in the ICU at the time of the first FEES examination. by Osbeck Sandblom et al., CC BY 4.0

PLOS ONE Characterization of dysphagia and laryngeal findings in COVID-19 patients treated in the ICU—An observational clinical study
June 4, 2021 Hanna Osbeck Sandblom, Hans Dotevall, Kristina Svennerholm, Lisa Tuomi, Caterina Finizia

Background: Dysphagia appears to be common in patients with severe COVID-19. Information about the characteristics of dysphagia and…
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Fig 2. Day 0 plasma ACE2 in COVID-19 positive patients by clinical outcome group and ROC curve. by Kragstrup et al., CC BY 4.0

PLOS ONE Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients
June 4, 2021 Tue W. Kragstrup, Helene Søgaard Singh, Ida Grundberg, Ane Langkilde-Lauesen Nielsen, Felice Rivellese, Arnav Mehta, Marcia B. Goldberg, Michael R. Filbin, Per Qvist, Bo Martin Bibby

Aims: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) enabling entrance of the…
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sadness by Georgie Pauwels, CC BY 2.0

PLOS ONE Assessment of depressive symptoms in patients with COVID-19 during the second wave of epidemic in Myanmar: A cross-sectional single-center study
June 4, 2021 Ye Minn Htun, Kyaw Thiha, Aung Aung, Nay Myo Aung, Thet Wai Oo, Pyae Sone Win, Nay Hein Sint, Kaung Myat Naing, Aung Khant Min, Kyaw Myo Tun, Kyaw Hlaing

Background: Coronavirus disease 2019 (COVID-19) pandemic has had a great impact on every aspect of society. All countries launched…
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Fig 1. Baseline and highest or lowest values for selected laboratory values in ESKD and non-ESKD groups. by Kamel et al., CC BY 4.0

PLOS ONE End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts
June 4, 2021 Mohamed Hassan Kamel, Hassan Mahmoud, Aileen Zhen, Jing Liu, Catherine G. Bielick, Anahita Mostaghim, Nina Lin, Vipul Chitalia, Titilayo Ilori, Sushrut S. Waikar, Ashish Upadhyay

Introduction: End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we…
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Fig 1. Schematic diagram of the contact tracing model. by James et al., CC BY 4.0

PLOS ONE Successful contact tracing systems for COVID-19 rely on effective quarantine and isolation
June 3, 2021 A. James, M. J. Plank, S. Hendy, R. Binny, A. Lustig, N. Steyn, A. Nesdale, A. Verrall

Models of contact tracing often over-simplify the effects of quarantine and isolation on disease transmission. We develop a model that…
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Fig 1. Data extraction and processing. by Tortolero et al., CC BY 4.0

PLOS ONE Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality
June 3, 2021 Guillermo A. Tortolero, Michael R. Brown, Shreela V. Sharma, Marcia C. de Oliveira Otto, Jose-Miguel Yamal, David Aguilar, Matt D. Gunther, Dania I. Mofleh, Rachel D. Harris, Jemima C. John, Paul S. de Vries, Ryan Ramphul, Dritana Marko Serbo, Jennifer Kiger, Deborah Banerjee, Nick Bonvino, Angela Merchant, Warren Clifford, Jenny Mikhail, Hua Xu, Robert E. Murphy, Qiang Wei, Farhaan S. Vahidy, Alanna C. Morrison, Eric Boerwinkle

Understanding sociodemographic, behavioral, clinical, and laboratory risk factors in patients diagnosed with COVID-19 is critically…
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Fig 2. PCA plot of IgM and IgG pan-CoV responses. by Chaudhury et al., CC BY 4.0

PLOS ONE Serological profiles of pan-coronavirus-specific responses in COVID-19 patients using a multiplexed electro-chemiluminescence-based testing platform
June 3, 2021 Sidhartha Chaudhury, Jack Hutter, Jessica S. Bolton, Shilpa Hakre, Evelyn Mose, Amy Wooten, William O’Connell, Joseph Hudak, Shelly J. Krebs, Janice M. Darden, Jason A. Regules, Clinton K. Murray, Kayvon Modjarrad, Paul Scott, Sheila Peel, Elke S. Bergmann-Leitner

Serological assessment of SARS-CoV-2 specific responses are an essential tool for determining the prevalence of past SARS-CoV-2 infections…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE The benefits of coronavirus suppression: A cost-benefit analysis of the response to the first wave of COVID-19 in the United States
June 3, 2021 James Broughel, Michael Kotrous

This paper estimates the benefits and costs of state suppression policies to “bend the curve” during the initial outbreak of COVID-19 in…
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Fig 1. Flowchart of patients included in our analysis. by Sen et al., CC BY 4.0

PLOS ONE Inhaled corticosteroids do not adversely impact outcomes in COVID-19 positive patients with COPD: An analysis of Cleveland Clinic’s COVID-19 registry
June 3, 2021 Payal Sen, Uddalak Majumdar, Joe Zein, Umur Hatipoğlu, Amy H. Attaway

Inhaled Corticosteroids (ICS) are commonly prescribed to patients with severe COPD and recurrent exacerbations. It is not known what…
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Fig 2. A one-way disposable sampling valve protected participants. by Snitz et al., CC BY 4.0

PLOS ONE Proof of concept for real-time detection of SARS CoV-2 infection with an electronic nose
June 2, 2021 Kobi Snitz, Michal Andelman-Gur, Liron Pinchover, Reut Weissgross, Aharon Weissbrod, Eva Mishor, Roni Zoller, Vera Linetsky, Abebe Medhanie, Sagit Shushan, Eli Jaffe, Noam Sobel

Rapid diagnosis is key to curtailing the Covid-19 pandemic. One path to such rapid diagnosis may rely on identifying volatile organic…
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Fig 1. Timing of NPIs by country. by Banholzer et al., CC BY 4.0

PLOS ONE Estimating the effects of non-pharmaceutical interventions on the number of new infections with COVID-19 during the first epidemic wave
June 2, 2021 Nicolas Banholzer, Eva van Weenen, Adrian Lison, Alberto Cenedese, Arne Seeliger, Bernhard Kratzwald, Daniel Tschernutter, Joan Puig Salles, Pierluigi Bottrighi, Sonja Lehtinen, Stefan Feuerriegel, Werner Vach

The novel coronavirus (SARS-CoV-2) has rapidly developed into a global epidemic. To control its spread, countries have implemented…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS Neglected Tropical Diseases Ivermectin as a potential treatment for COVID-19?
June 1, 2021 Olivier Chosidow, Charlotte Bernigaud, Didier Guillemot, Bruno Giraudeau, Anne Lespine, Jean-Pierre Changeux, Hervé Bourhy, Marc Lecuit, Zahir Amoura

…
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Fig 1. SDS-PAGE analysis of SARS-CoV-2 S1 spike-specific IgY carried out under reducing conditions. by Artman et al., CC BY 4.0

PLOS ONE Avian antibodies (IgY) targeting spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit receptor binding and viral replication
May 28, 2021 Chad Artman, Kyle D. Brumfield, Sahil Khanna, Julius Goepp

Background: The global pandemic of Coronavirus infectious disease 2019 (COVID-19), caused by SARS-CoV-2, has plunged the world into both…
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Fig 3. PCA plot (Day 90). by Teh et al., CC BY 4.0

PLOS ONE Multivariate visualization of the global COVID-19 pandemic: A comparison of 161 countries
May 28, 2021 Jane K. L. Teh, David A. Bradley, Jack Bee Chook, Kee Huong Lai, Woo Teck Ang, Kok Lay Teo, Suat-Cheng Peh

Background: The aim of the study was to visualize the global spread of the COVID-19 pandemic over the first 90 days, through the principal…
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Fig 2. CLIR plot by multiple conditions of 159 DBS samples with serum SARS-CoV-2 antibody results. by Turgeon et al., CC BY 4.0

PLOS ONE Validation of a multiplex flow immunoassay for detection of IgG antibodies against SARS-CoV-2 in dried blood spots
May 28, 2021 Coleman T. Turgeon, Karen A. Sanders, Piero Rinaldo, Dane Granger, Heather Hilgart, Dietrich Matern, Elitza S. Theel

Background: Dried blood spots (DBS) are an established specimen type for clinical testing given their low cost, ease of collection and…
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Fig 2. Sensitivity of PanBio Ag-RDT compared to viral load for all PCR positive cases (105 participants). by Krüger et al., CC BY 4.0

PLOS ONE The Abbott PanBio WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic test for SARS-CoV-2—Evaluation of the accuracy and ease-of-use
May 27, 2021 Lisa J. Krüger, Mary Gaeddert, Frank Tobian, Federica Lainati, Claudius Gottschalk, Julian A. F. Klein, Paul Schnitzler, Hans-Georg Kräusslich, Olga Nikolai, Andreas K. Lindner, Frank P. Mockenhaupt, Joachim Seybold, Victor M. Corman, Christian Drosten, Nira R. Pollock, Britta Knorr, Andreas Welker, Margaretha de Vos, Jilian A. Sacks, Claudia M. Denkinger, for the study team

Objectives: Diagnostics are essential for controlling the pandemic. Identifying a reliable and fast diagnostic device is needed for…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Determinants of in-hospital mortality in COVID-19; a prospective cohort study from Pakistan
May 27, 2021 Samreen Sarfaraz, Quratulain Shaikh, Syed Ghazanfar Saleem, Anum Rahim, Fivzia Farooq Herekar, Samina Junejo, Aneela Hussain

A prospective cohort study was conducted at the Indus Hospital Karachi, Pakistan between March and June 2020 to estimate the in-hospital…
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Syringe and Vaccine by NIH, CC BY 2.0

PLOS ONE Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda
May 27, 2021 Jonathan Kitonsa, Onesmus Kamacooko, Ubaldo Mushabe Bahemuka, Freddie Kibengo, Ayoub Kakande, Anne Wajja, Vincent Basajja, Alfred Lumala, Edward Ssemwanga, Robert Asaba, Joseph Mugisha, Benjamin F. Pierce, Robin Shattock, Pontiano Kaleebu, Eugene Ruzagira

Background: Healthcare workers (HCWs) are at high risk of acquiring SARS-CoV-2 and COVID-19 and may therefore be a suitable population for…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE The systemic inflammatory response and clinicopathological characteristics in patients admitted to hospital with COVID-19 infection: Comparison of 2 consecutive cohorts
May 27, 2021 Donogh Maguire, Conor Richards, Marylynne Woods, Ross Dolan, Jesse Wilson Veitch, Wei M. J. Sim, Olivia E. H. Kemmett, David C. Milton, Sophie L. W. Randall, Ly D. Bui, Nicola Goldmann, Amy Brown, Eilidh Gillen, Allan Cameron, Barry Laird, Dinesh Talwar, Ian M. Godber, John Wadsworth, Anthony Catchpole, Alan Davidson, Donald C. McMillan

Background: In order to manage the COVID-19 systemic inflammatory response, it is important to identify clinicopathological characteristics…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Seroprevalence of SARS-CoV-2 antibodies in Seattle, Washington: October 2019–April 2020
May 27, 2021 Denise J. McCulloch, Michael L. Jackson, James P. Hughes, Sandra Lester, Lisa Mills, Brandi Freeman, Mohammad Ata Ur Rasheed, Natalie J. Thornburg, Helen Y. Chu

Background: The first US case of SARS-CoV-2 infection was detected on January 20, 2020. However, some serology studies suggest SARS-CoV-2…
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Fig 2. by Dragon-Durey et al., CC BY 4.0

PLOS ONE Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity
May 26, 2021 Marie-Agnès Dragon-Durey, Xiaoyi Chen, Amos Kirilovsky, Nadine Ben Hamouda, Carine El Sissy, Jules Russick, Etienne Charpentier, Yannick Binois, Florence Marliot, Maxime Meylan, Clémence Granier, Hélène Pere, Antonin Saldmann, Bastien Rance, Anne Sophie Jannot, Stéphanie Baron, Mouna Chebbi, Antoine Fayol, Nathalie Josseaume, Claire Rives-Lange, Pierre-Louis Tharaux, Bernard Cholley, Jean-Luc Diehl, Jean-Benoît Arlet, Michel Azizi, Alexandre Karras, Sébastien Czernichow, David M. Smadja, Jean-Sébastien Hulot, Isabelle Cremer, Eric Tartour, Elie Mousseaux, Franck Pagès

To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective…
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Fig 2. The SARS-CoV-2 outbreak in the Netherlands. by Tomokazu Konishi, CC BY 4.0

PLOS ONE SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans
May 26, 2021 Tomokazu Konishi

SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to…
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Fig 3. Identiication of SARS-CoV-2 genetic clusters in different continents. by Haddad et al., CC BY 4.0

PLOS ONE SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains
May 25, 2021 Dania Haddad, Sumi Elsa John, Anwar Mohammad, Maha M. Hammad, Prashantha Hebbar, Arshad Channanath, Rasheeba Nizam, Sarah Al-Qabandi, Ashraf Al Madhoun, Abdullah Alshukry, Hamad Ali, Thangavel Alphonse Thanaraj, Fahd Al-Mulla

COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this…
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Fig 3. by Pinzón et al., CC BY 4.0

PLOS ONE Dexamethasone vs methylprednisolone high dose for Covid-19 pneumonia
May 25, 2021 Miguel Alejandro Pinzón, Santiago Ortiz, Héctor Holguín, Juan Felipe Betancur, Doris Cardona Arango, Henry Laniado, Carolina Arias Arias, Bernardo Muñoz, Julián Quiceno, Daniel Jaramillo, Zoraida Ramirez

Background: There is no effective therapy for the severe acute respiratory syndrome by coronavirus 2 (SARS-CoV2) responsible for the…
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Fig 3. Correlation matrix among clinical variables at hospital admission and discharge. by de Almeida et al., CC BY 4.0

PLOS ONE Acute kidney injury: Incidence, risk factors, and outcomes in severe COVID-19 patients
May 25, 2021 Danilo Candido de Almeida, Maria do Carmo Pinho Franco, Davi Rettori Pardo dos Santos, Marina Colella Santos, Isabela Soucin Maltoni, Felipe Mascotte, Alexandra Aparecida de Souza, Paula Massaroni Pietrobom, Eduardo Alexandrino Medeiros, Paulo Roberto Abrão Ferreira, Flavia Ribeiro Machado, Miguel Angelo Goes

Background: COVID-19 is a multisystemic disorder that frequently causes acute kidney injury (AKI). However, the precise clinical and…
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Fig 2. Hypothetical model for thrombotic thrombocytopenia after adenoviral vector-based COVID-19 vaccines. by Goldman and Hermans, CC BY 4.0

PLOS Medicine Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity
May 24, 2021 Michel Goldman, Cédric Hermans

Michel Goldman and Cédric Hermans discuss thrombotic mechanisms in COVID-19 and rare adverse reactions to SARS-CoV-2…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS Neglected Tropical Diseases COVID-19 and helminth infection: Beyond the Th1/Th2 paradigm
May 24, 2021 Alberto E. Paniz-Mondolfi, Juan David Ramírez, Lourdes A. Delgado-Noguera, Alfonso J. Rodriguez-Morales, Emilia M. Sordillo

…
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Fig 1. Forest plot of willingness to vaccinate by demographics. by Nikolovski et al., CC BY 4.0

PLOS ONE Factors indicating intention to vaccinate with a COVID-19 vaccine among older U.S. adults
May 24, 2021 Janeta Nikolovski, Martin Koldijk, Gerrit Jan Weverling, John Spertus, Mintu Turakhia, Leslie Saxon, Mike Gibson, John Whang, Troy Sarich, Robert Zambon, Nnamdi Ezeanochie, Jennifer Turgiss, Robyn Jones, Jeff Stoddard, Paul Burton, Ann Marie Navar

Background: The success of vaccination efforts to curb the COVID-19 pandemic will require broad public uptake of immunization and…
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Fig 3. Clinical SARS-CoV-2 RT-PCR sensitivity estimates in the laboratory confirmed, and in the laboratory confirmed and high suspicion group combined, presented according to delay (days) from symptom onset to sampling. by Kortela et al., CC BY 4.0

PLOS ONE Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients
May 21, 2021 Elisa Kortela, Vesa Kirjavainen, Maarit J. Ahava, Suvi T. Jokiranta, Anna But, Anna Lindahl, Anu E. Jääskeläinen, Annemarjut J. Jääskeläinen, Asko Järvinen, Pia Jokela, Hannimari Kallio-Kokko, Raisa Loginov, Laura Mannonen, Eeva Ruotsalainen, Tarja Sironen, Olli Vapalahti, Maija Lappalainen, Hanna-Riikka Kreivi, Hanna Jarva, Satu Kurkela, Eliisa Kekäläinen

Background: Understanding the false negative rates of SARS-CoV-2 RT-PCR testing is pivotal for the management of the COVID-19 pandemic and…
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Fig 1. Difference between the 2020 all-cause mortality rate and 2013–2018 historical mortality rate vs. 2020 direct COVID-19 mortality rate (n = 2,096)^a,b,c. by Stokes et al., CC BY 4.0

PLOS Medicine COVID-19 and excess mortality in the United States: A county-level analysis
May 20, 2021 Andrew C. Stokes, Dielle J. Lundberg, Irma T. Elo, Katherine Hempstead, Jacob Bor, Samuel H. Preston

Background: Coronavirus Disease 2019 (COVID-19) excess deaths refer to increases in mortality over what would normally have been expected…
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Fig 3. Geographical distribution of pregnant women with COVID-19, and medical facilities where community-acquired infection of COVID-19 occurred in Japan (-2020 June). by Hasegawa et al., CC BY 4.0

PLOS ONE Current status of community-acquired infection of COVID-19 in delivery facilities in Japan
May 20, 2021 Junichi Hasegawa, Tatsuya Arakaki, Akihiko Sekizawa, Tomoaki Ikeda, Isamu Ishiwata, Katsuyuki Kinoshita, on behalf of department of medical safety, the Japan Association of Obstetricians and Gynecologists (JAOG)

A nationwide questionnaire survey about community-acquired infection of coronavirus disease 2019 (COVID-19) was conducted in July 2020 to…
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Fig 3. Funnel plot of the association between the DPP-4i use and the mortality of COVID-19. by Yang et al., CC BY 4.0

PLOS ONE DPP-4 inhibitors may improve the mortality of coronavirus disease 2019: A meta-analysis
May 20, 2021 Yan Yang, Zixin Cai, Jingjing Zhang

Aims: DPP-4 inhibitors are predicted to exert a protective effect on the progression of coronavirus disease 2019 (COVID-19). We conducted…
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Fig 7. Receiver operating characteristic (ROC) curves analysis of total score for assessing the risk of respiratory support in COVID-19. by Rorat et al., CC BY 4.0

PLOS ONE Value of quantitative analysis in lung computed tomography in patients severely ill with COVID-19
May 20, 2021 Marta Rorat, Tomasz Jurek, Krzysztof Simon, Maciej Guziński

Introduction: Quantitative computed tomography (QCT) is used to objectively assess the degree of parenchymal impairment in COVID-19…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Incidence of deep vein thrombosis through an ultrasound surveillance protocol in patients with COVID-19 pneumonia in non-ICU setting: A multicenter prospective study
May 20, 2021 Filippo Pieralli, Fulvio Pomero, Margherita Giampieri, Rossella Marcucci, Domenico Prisco, Fabio Luise, Antonio Mancini, Alessandro Milia, Lucia Sammicheli, Irene Tassinari, Francesca Caldi, Francesca Innocenti, Antonio Faraone, Chiara Beltrame, Riccardo Pini, Andrea Ungar, Alberto Fortini

Objective: The aim of this study was to assess the incidence of deep vein thrombosis (DVT) of the lower limbs, using serial compression…
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Fig 2. OneR model diagnostic plot. by Herzog et al., CC BY 4.0

PLOS ONE COVID-19 and the kidney: A retrospective analysis of 37 critically ill patients using machine learning
May 20, 2021 Anna Laura Herzog, Holger K. von Jouanne-Diedrich, Christoph Wanner, Dirk Weismann, Tobias Schlesinger, Patrick Meybohm, Jan Stumpner

Introduction: There is evidence that SARS-CoV2 has a particular affinity for kidney tissue and is often associated with kidney failure.…
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Untitled by Dellicour et al., CC BY 4.0

PLOS Pathogens Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
May 20, 2021 Simon Dellicour, Samuel L. Hong, Bram Vrancken, Antoine Chaillon, Mandev S. Gill, Matthew T. Maurano, Sitharam Ramaswami, Paul Zappile, Christian Marier, Gordon W. Harkins, Guy Baele, Ralf Duerr, Adriana Heguy

During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While…
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Fig 2. Neuron-Specific Enolase (NSE) serum levels. by Cione et al., CC BY 4.0

PLOS ONE Neuron-specific enolase serum levels in COVID-19 are related to the severity of lung injury
May 19, 2021 Erika Cione, Antonio Siniscalchi, Pietro Gangemi, Lucio Cosco, Manuela Colosimo, Federico Longhini, Filippo Luciani, Giovambattista De Sarro, G&SP Working Group , Liberato Berrino, Bruno D’Agostino, Luca Gallelli

The multifunctional role of neuron-specific enolase (NSE) in lung diseases is well established. As the lungs are greatly affected in…
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Pregnant woman by sergio santos, CC BY 2.0

PLOS ONE Available medications used as potential therapeutics for COVID-19: What are the known safety profiles in pregnancy
May 19, 2021 Anick Bérard, Odile Sheehy, Jin-Ping Zhao, Evelyne Vinet, Caroline Quach, Behrouz Kassai, Sasha Bernatsky

Background: Medications already available to treat other conditions are presently being studied in clinical trials as potential treatments…
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Untitled by Garzon-Chavez et al., CC BY 4.0

PLOS ONE Adapting for the COVID-19 pandemic in Ecuador, a characterization of hospital strategies and patients
May 17, 2021 Daniel Garzon-Chavez, Daniel Romero-Alvarez, Marco Bonifaz, Juan Gaviria, Daniel Mero, Narcisa Gunsha, Asiris Perez, María Garcia, Hugo Espejo, Franklin Espinosa, Edison Ligña, Mauricio Espinel, Emmanuelle Quentin, Enrique Teran, Francisco Mora, Jorge Reyes

The World Health Organization (WHO) declared coronavirus disease-2019 (COVID-19) a global pandemic on 11 March 2020. In Ecuador, the first…
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Fig 2. Resonant frequencies f (in GHz) corresponding to respective V_L (in m/s) for different diameters D (in nm) of EV71 virus. by Barbora and Minnes, CC BY 4.0

PLOS ONE Targeted antiviral treatment using non-ionizing radiation therapy for SARS-CoV-2 and viral pandemics preparedness: Technique, methods and practical notes for clinical application
May 14, 2021 Ayan Barbora, Refael Minnes

Objective: Pandemic outbreaks necessitate effective responses to rapidly mitigate and control the spread of disease and eliminate the…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients
May 14, 2021 Giulia Besutti, Massimo Pellegrini, Marta Ottone, Michele Cantini, Jovana Milic, Efrem Bonelli, Giovanni Dolci, Giulia Cassone, Guido Ligabue, Lucia Spaggiari, Pierpaolo Pattacini, Tommaso Fasano, Simone Canovi, Marco Massari, Carlo Salvarani, Giovanni Guaraldi, Paolo Giorgi Rossi, on behalf of the Reggio Emilia COVID-19 Working Group

We assessed the impact of chest CT body composition parameters on outcomes and disease severity at hospital presentation of COVID-19…
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Fig 1. Temporal distribution of COVID-19 cases and their deaths in the capitals of the Northeast of Brazil. by Costa de Assis et al., CC BY 4.0

PLOS ONE Primary health care and social isolation against COVID-19 in Northeastern Brazil: Ecological time-series study
May 13, 2021 Sanderson José Costa de Assis, Johnnatas Mikael Lopes, Marcello Barbosa Otoni Gonçalves Guedes, Geronimo José Bouzas Sanchis, Diego Neves Araujo, Angelo Giuseppe Roncalli

Background: Brazil is witnessing a massive increase of corona virus disease (COVID-19). Its peculiar primary health care (PHC) system faces…
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Fig 4. Lockdown and travel restriction policy intensity from government and agent over time. by Kwak et al., CC BY 4.0

PLOS ONE Deep reinforcement learning approaches for global public health strategies for COVID-19 pandemic
May 13, 2021 Gloria Hyunjung Kwak, Lowell Ling, Pan Hui

Background: Unprecedented public health measures have been used during this coronavirus 2019 (COVID-19) pandemic to control the spread of…
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Fig 3. p-values of the differences between non-ARDS patients and ARDS patients for the four immunoassays at different time points. by Buchholtz et al., CC BY 4.0

PLOS ONE SARS-CoV-2 antibody immunoassays in serial samples reveal earlier seroconversion in acutely ill COVID-19 patients developing ARDS
May 13, 2021 Marie-Luise Buchholtz, Florian M. Arend, Peter Eichhorn, Michael Weigand, Alisa Kleinhempel, Kurt Häusler, Mathias Bruegel, Lesca M. Holdt, Daniel Teupser

Objectives: During the COVID-19 pandemic, SARS-CoV-2 antibody testing has been suggested for (1) screening populations for disease…
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Fig 2. by Peng et al., CC BY 4.0

PLOS ONE Clinical course and management of 73 hospitalized moderate patients with COVID-19 outside Wuhan
May 13, 2021 Xiaojuan Peng, Qi Liu, Zhaolin Chen, Guiyan Wen, Qing Li, Yanfang Chen, Jie Xiong, Xinzhou Meng, Yuanjin Ding, Ying Shi, Shaohui Tang

Moderate cases account for the majority in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
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Fig 1. Scheme of the possible infection rules according to RhD blood types and ABO ones. by Miotto et al., CC BY 4.0

PLOS ONE Does blood type affect the COVID-19 infection pattern?
May 13, 2021 Mattia Miotto, Lorenzo Di Rienzo, Giorgio Gosti, Edoardo Milanetti, Giancarlo Ruocco

Among the many aspects that characterize the COVID-19 pandemic, two seem particularly challenging to understand: i) the great geographical…
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Fig 2. Diagram for the flow of participants for part 2 of the study (qRT-PCR positive participants only). by Van der Moeren et al., CC BY 4.0

PLOS ONE Evaluation of the test accuracy of a SARS-CoV-2 rapid antigen test in symptomatic community dwelling individuals in the Netherlands
May 13, 2021 Nathalie Van der Moeren, Vivian F. Zwart, Esther B. Lodder, Wouter Van den Bijllaardt, Harald R. J. M. Van Esch, Joep J. J. M. Stohr, Joost Pot, Ineke Welschen, Petra M. F. Van Mechelen, Suzan D. Pas, Jan A. J. W. Kluytmans

Background: SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction (qRT-PCR) is well suited for the diagnosis of clinically…
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Fig 1. Location of Mutukula border entry point into Uganda. by Nsawotebba et al., CC BY 4.0

PLOS ONE Effectiveness of thermal screening in detection of COVID-19 among truck drivers at Mutukula Land Point of Entry, Uganda
May 13, 2021 Andrew Nsawotebba, Ivan Ibanda, Isaac Ssewanyana, Patrick Ogwok, Francis Ocen, Christopher Okiira, Atek Kagirita, Dennis Mujuni, Didas Tugumisirize, Joel Kabugo, Abdunoor Nyombi, Robert Kaos Majwala, Bernard Ssentalo Bagaya, Simeon Kalyesubula-Kibuuka, Willy Ssengooba, Susan Nabadda

Introduction: Despite the limited evidence for its effectiveness, thermal screening at points of entry has increasingly become a standard…
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Fig 1. COVID-19 postmortem donor eye. by Bayyoud et al., CC BY 4.0

PLOS ONE Severe acute respiratory Syndrome-Coronavirus-2: Can it be detected in the retina?
May 13, 2021 Tarek Bayyoud, Angelika Iftner, Thomas Iftner, Karl Ulrich Bartz-Schmidt, Focke Ziemssen, Hans Bösmüller, Falko Fend, Jens Martin Rohrbach, Marius Ueffing, Michael Schindler, Sebastian Thaler

Background/Objectives: The systemic organ involvement of SARS-CoV-2 needs to be thoroughly investigated including the possibility of an…
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Fig 1. Changes in FEV₁ (% of predicted) among patients who tested positive for SARS-CoV-2 (cases) by PCR analysis and those who tested negative (controls)^a. by Colombo et al., CC BY 4.0

PLOS ONE SARS-CoV-2 infection in cystic fibrosis: A multicentre prospective study with a control group, Italy, February-July 2020
May 13, 2021 Carla Colombo, Gianfranco Alicandro, Valeria Daccó, Vanessa Gagliano, Letizia Corinna Morlacchi, Rosaria Casciaro, Giovanna Pisi, Michela Francalanci, Raffaele Badolato, Elisabetta Bignamini, Barbara Messore, Maria Cristina Lucanto, Giuseppina Leonetti, Massimo Maschio, Marco Cipolli, on behalf of the Italian Cystic Fibrosis Society (SIFC) Study Group for COVID-19

Objective: To describe the symptoms and clinical course of SARS-CoV-2 infection in patients with cystic fibrosis (CF). Methods: We carried…
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Fig 3. Heat map of phenotypes associated with COVID-19 outcomes. by Song et al., CC BY 4.0

PLOS ONE Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program
May 13, 2021 Rebecca J. Song, Yuk-Lam Ho, Petra Schubert, Yojin Park, Daniel Posner, Emily M. Lord, Lauren Costa, Hanna Gerlovin, Katherine E. Kurgansky, Tori Anglin-Foote, Scott DuVall, Jennifer E. Huffman, Saiju Pyarajan, Jean C. Beckham, Kyong-Mi Chang, Katherine P. Liao, Luc Djousse, David R. Gagnon, Stacey B. Whitbourne, Rachel Ramoni, Sumitra Muralidhar, Philip S. Tsao, Christopher J. O’Donnell, John Michael Gaziano, Juan P. Casas, Kelly Cho, on behalf of the VA Million Veteran Program COVID-19 Science Initiative

Background: The risk factors associated with the stages of Coronavirus Disease-2019 (COVID-19) disease progression are not well known. We…
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Fig 1. Projections of daily PEH isolation bed demand with 95% prediction intervals under seven intervention scenarios. by Ingle et al., CC BY 4.0

PLOS ONE Projecting COVID-19 isolation bed requirements for people experiencing homelessness
May 12, 2021 Tanvi A. Ingle, Maike Morrison, Xutong Wang, Timothy Mercer, Vella Karman, Spencer Fox, Lauren Ancel Meyers

As COVID-19 spreads across the United States, people experiencing homelessness (PEH) are among the most vulnerable to the virus. To…
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Fig 1. Epidemic curve of COVID-19 cases at the Djoungolo Hospital. by Fouda Mbarga et al., CC BY 4.0

PLOS ONE Clinical profile and factors associated with COVID-19 in Yaounde, Cameroon: A prospective cohort study
May 12, 2021 Nicole Fouda Mbarga, Emilienne Epee, Marcel Mbarga, Patrick Ouamba, Herwin Nanda, Aristide Nkengni, Joseph Guekeme, Justin Eyong, Sylvie Tossoukpe, Sauvia Noumedem Sosso, Engelbert Ngono Ngono, Lazare Mbala Ntsama, Landry Bonyomo, Patrick Tchatchoua, Noel Vogue, Steve Metomb, Franck Ale, Moussa Ousman, Dorian Job, Charlotte Moussi, Modeste Tamakloe, Jessica E. Haberer, Sylvester Ndeso Atanga, Gregory Halle-Ekane, Yap Boum II

Background: A year after the COVID-19 pandemic started, there are still few scientific reports on COVID-19 in Africa. This study explores…
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Fig 2. Lopinavir/ritonavir and hydroxychloroquine (triple therapy) are associated with an increase in the incidence of Acute Kidney Injury (AKI). by Schneider et al., CC BY 4.0

PLOS ONE Therapy with lopinavir/ritonavir and hydroxychloroquine is associated with acute kidney injury in COVID-19 patients
May 11, 2021 Johanna Schneider, Bernd Jaenigen, Dirk Wagner, Siegbert Rieg, Daniel Hornuss, Paul M. Biever, Winfried V. Kern, Gerd Walz

Background: Acute kidney injury (AKI) is an independent risk factor for mortality, which affects about 5% of hospitalized coronavirus…
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Fig 2. Raspberry Pi 4 model B hardware design. by Hosny et al., CC BY 4.0

PLOS ONE COVID-19 diagnosis from CT scans and chest X-ray images using low-cost Raspberry Pi
May 11, 2021 Khalid M. Hosny, Mohamed M. Darwish, Kenli Li, Ahmad Salah

The diagnosis of COVID-19 is of vital demand. Several studies have been conducted to decide whether the chest X-ray and computed…
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Fig 2. Antibiotic prescription variation over time. by Calderón-Parra et al., CC BY 4.0

PLOS ONE Inappropriate antibiotic use in the COVID-19 era: Factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID
May 11, 2021 Jorge Calderón-Parra, Antonio Muiño-Miguez, Alejandro D. Bendala-Estrada, Antonio Ramos-Martínez, Elena Muñez-Rubio, Eduardo Fernández Carracedo, Javier Tejada Montes, Manuel Rubio-Rivas, Francisco Arnalich-Fernandez, Jose Luis Beato Pérez, Jose Miguel García Bruñén, Esther del Corral Beamonte, Paula Maria Pesqueira Fontan, Maria del Mar Carmona, Rosa Fernández-Madera Martínez, Andrés González García, Cristina Salazar Mosteiro, Carlota Tuñón de Almeida, Julio González Moraleja, Francesco Deodati, María Dolores Martín Escalante, María Luisa Asensio Tomás, Ricardo Gómez Huelgas, José Manuel Casas Rojo, Jesús Millán Núñez-Cortés, for the SEMI-COVID-19 Network

Background: Most patients with COVID-19 receive antibiotics despite the fact that bacterial co-infections are rare. This can lead to…
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Fig 2. Locations of ICU responders. by Brewster et al., CC BY 4.0

PLOS ONE Preparation for airway management in Australia and New Zealand ICUs during the COVID -19 pandemic
May 7, 2021 David J. Brewster, Christopher P. Nickson, Steve McGloughlin, David Pilcher, Vineet V. Sarode, Jonathan J. Gatward

Background: This paper aimed to describe the airway practices of intensive care units (ICUs) in Australia and New Zealand specific to…
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Fig 3. Top row left-to-right: Confusion matrices for ai-corona, the model proposed by Zhang et al. [29], and the model proposed by Jin et al. [30] for the CC-CCI test set, respectively. by Yousefzadeh et al., CC BY 4.0

PLOS ONE ai-corona: Radiologist-assistant deep learning framework for COVID-19 diagnosis in chest CT scans
May 7, 2021 Mehdi Yousefzadeh, Parsa Esfahanian, Seyed Mohammad Sadegh Movahed, Saeid Gorgin, Dara Rahmati, Atefeh Abedini, Seyed Alireza Nadji, Sara Haseli, Mehrdad Bakhshayesh Karam, Arda Kiani, Meisam Hoseinyazdi, Jafar Roshandel, Reza Lashgari

The development of medical assisting tools based on artificial intelligence advances is essential in the global fight against COVID-19…
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Fig 1. Evolution of cumulative cases, deaths, and policy milestones in Chile and the Metropolitan Region (March-July, 2020). by Villalobos Dintrans et al., CC BY 4.0

PLOS ONE COVID-19 incidence and mortality in the Metropolitan Region, Chile: Time, space, and structural factors
May 6, 2021 Pablo Villalobos Dintrans, Claudio Castillo, Felipe de la Fuente, Matilde Maddaleno

Demographic, health, and socioeconomic factors significantly inform COVID-19 outcomes. This article analyzes the association of these…
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Fig 3. Forest plot of pooled prevalence of superinfection in patients infected with SARS-CoV-2. by Musuuza et al., CC BY 4.0

PLOS ONE Prevalence and outcomes of co-infection and superinfection with SARS-CoV-2 and other pathogens: A systematic review and meta-analysis
May 6, 2021 Jackson S. Musuuza, Lauren Watson, Vishala Parmasad, Nathan Putman-Buehler, Leslie Christensen, Nasia Safdar

Introduction: The recovery of other pathogens in patients with SARS-CoV-2 infection has been reported, either at the time of a SARS-CoV-2…
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Fig 1. Sense of preparedness to serve in COVID-19 pandemic. by Barqawi et al., CC BY 4.0

PLOS ONE Readiness of physicians and medical students to cope with the COVID-19 pandemic in the UAE
May 6, 2021 Hiba J. Barqawi, Drishti D. Kampani, Enad S. Haddad, Nora M. Al-Roub, Eman Abu-Gharbieh

Background: Coronavirus disease (COVID-19), caused by Severe Acute Respiratory Syndrome–Coronavirus 2 (SARS-CoV2), is the defining global…
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Fig 1. Correlogram figuring out the relationship between each pair of clinical or biological variables in COVID-19 patients. by Bats et al., CC BY 4.0

PLOS ONE Covichem: A biochemical severity risk score of COVID-19 upon hospital admission
May 6, 2021 Marie-Lise Bats, Benoit Rucheton, Tara Fleur, Arthur Orieux, Clément Chemin, Sébastien Rubin, Brigitte Colombies, Arnaud Desclaux, Claire Rivoisy, Etienne Mériglier, Etienne Rivière, Alexandre Boyer, Didier Gruson, Isabelle Pellegrin, Pascale Trimoulet, Isabelle Garrigue, Rana Alkouri, Charles Dupin, François Moreau-Gaudry, Aurélie Bedel, Sandrine Dabernat

Clinical and laboratory predictors of COVID-19 severity are now well described and combined to propose mortality or severity scores.…
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Fig 1. Geographic location of sample collection sites in this study. by Megasari et al., CC BY 4.0

PLOS ONE Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
May 6, 2021 Ni Luh Ayu Megasari, Takako Utsumi, Laura Navika Yamani, Juniastuti, Emily Gunawan, Koichi Furukawa, Mitsuhiro Nishimura, Maria Inge Lusida, Yasuko Mori

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic,…
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run by brett lohmeyer, CC BY 2.0

PLOS ONE The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study
May 5, 2021 Rebecca A. G. Christensen, Jasleen Arneja, Kate St. Cyr, Shelby L. Sturrock, Jennifer D. Brooks

Background: It has been suggested that cardiorespiratory fitness (CRF) may be used to identify those at greatest risk for severe COVID-19…
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Fig 2. RT-LAMP assay limit of detection. by Uribe-Alvarez et al., CC BY 4.0

PLOS ONE Low saliva pH can yield false positives results in simple RT-LAMP-based SARS-CoV-2 diagnostic tests
May 5, 2021 Cristina Uribe-Alvarez, Quynh Lam, Don A. Baldwin, Jonathan Chernoff

Diagnosis of any infectious disease is vital for opportune treatment and to prevent dissemination. RT-qPCR tests for detection of…
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Fig 1. Number of pregnant women admitted to hospital with symptomatic and asymptomatic confirmed SARS-CoV-2 infection in the UK between 1^st March and 31^{st by Vousden et al.,}CC BY 4.0

PLOS ONE The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: A national cohort study using the UK Obstetric Surveillance System (UKOSS)
May 5, 2021 Nicola Vousden, Kathryn Bunch, Edward Morris, Nigel Simpson, Christopher Gale, Patrick O’Brien, Maria Quigley, Peter Brocklehurst, Jennifer J. Kurinczuk, Marian Knight

Background: There is a lack of population level data on risk factors, incidence and impact of SARS-CoV-2 infection in pregnant women and…
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Fig 1. Schematic diagram of the seven steps of the methodological framework according to PRISMA. by Dzinamarira et al., CC BY 4.0

PLOS ONE Risk factors for COVID-19 among healthcare workers. A protocol for a systematic review and meta-analysis
May 4, 2021 Tafadzwa Dzinamarira, Malizgani Mhango, Mathias Dzobo, Bernard Ngara, Itai Chitungo, Pelagia Makanda, James Atwine, Sphamandla Josias Nkambule, Godfrey Musuka

Background: Evidence on the spectrum of risk factors for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among…
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Fig 3. Interval from initial to recurrent positive SARS-CoV-2 RT-PCR. by Peltan et al., CC BY 4.0

PLOS ONE Evaluation of potential COVID-19 recurrence in patients with late repeat positive SARS-CoV-2 testing
May 4, 2021 Ithan D. Peltan, Sarah J. Beesley, Brandon J. Webb, Bert K. Lopansri, Will Sinclair, Jason R. Jacobs, Samuel M. Brown

Background: SARS-CoV-2 reinfection and reactivation has mostly been described in case reports. We therefore investigated the epidemiology…
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Fig 5. Meta-regression by median age of patients. by Li et al., CC BY 4.0

PLOS ONE Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis
May 3, 2021 Xinyang Li, Xianrui Zhong, Yongbo Wang, Xiantao Zeng, Ting Luo, Qing Liu

Objective: We aimed to systematically identify the possible risk factors responsible for severe cases. Methods: We searched PubMed, Embase,…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Low serum albumin and the risk of hospitalization in COVID-19 infection: A retrospective case-control study
April 30, 2021 Roshan Acharya, Dilli Poudel, Aakash Patel, Evan Schultz, Michael Bourgeois, Rishi Paswan, Scott Stockholm, Macylen Batten, Smita Kafle, Amanda Atkinson, Hafiz Sarwar

Background: The data on the COVID-19 patients who were discharged to self-quarantine is lacking. Aim: The aim of the study was to…
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Fig 2. by Elhadi et al., CC BY 4.0

PLOS ONE Epidemiology, outcomes, and utilization of intensive care unit resources for critically ill COVID-19 patients in Libya: A prospective multi-center cohort study
April 30, 2021 Muhammed Elhadi, Ahmed Alsoufi, Abdurraouf Abusalama, Akram Alkaseek, Saedah Abdeewi, Mohammed Yahya, Alsnosy Mohammed, Mohammed Abdelkabir, Mohammed Huwaysh, Emad Amkhatirah, Kamel Alshorbaji, Samer Khel, Marwa Gamra, Abdulmueti Alhadi, Taha Abubaker, Mohamed Anaiba, Mohammed Elmugassabi, Muhannud Binnawara, Ala Khaled, Ahmed Zaid, Ahmed Msherghi

Background: The coronavirus disease (COVID-19) pandemic has severely affected African countries, specifically the countries, such as Libya,…
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Fig 2. Graph plotting raw Ct values (y-axis) for all 641 positive samples in the Birmingham Turnkey lab (y-axis). by Ferguson et al., CC BY 4.0

PLOS Biology Validation testing to determine the sensitivity of lateral flow testing for asymptomatic SARS-CoV-2 detection in low prevalence settings: Testing frequency and public health messaging is key
April 29, 2021 Jack Ferguson, Steven Dunn, Angus Best, Jeremy Mirza, Benita Percival, Megan Mayhew, Oliver Megram, Fiona Ashford, Thomas White, Emma Moles-Garcia, Liam Crawford, Tim Plant, Andrew Bosworth, Michael Kidd, Alex Richter, Jonathan Deeks, Alan McNally

Lateral flow devices (LFDs) are quickly being implemented for use in large-scale population surveillance programs for SARS-CoV-2 infection…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Risk factors for COVID-19 mortality: The effect of convalescent plasma administration
April 29, 2021 Martín R. Salazar, Soledad E. González, Lorena Regairaz, Noelia S. Ferrando, Verónica V. González Martínez, Patricia M. Carrera Ramos, Laura Muñoz, Santiago A. Pesci, Juan M. Vidal, Nicolás Kreplak, Elisa Estenssoro

Background: Convalescent plasma, widely utilized in viral infections that induce neutralizing antibodies, has been proposed for COVID-19,…
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Novel Coronavirus SARS-CoV-2 Spike Protein by NIH, CC-0 Public Domain

PLOS ONE Epidemiological, clinical, and laboratory findings for patients of different age groups with confirmed coronavirus disease 2019 (COVID-19) in a hospital in Saudi Arabia
April 29, 2021 Mutasim E. Ibrahim, Obaid S. AL-Aklobi, Mosleh M. Abomughaid, Mushabab A. Al-Ghamdi

Background: Although the coronavirus disease 2019 (COVID-19) pandemic continues to rage worldwide, clinical and laboratory studies of this…
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Novel Coronavirus SARS-CoV-2 by NIH, CC-0 Public Domain

PLOS ONE Assessment of exposure risks to COVID-19 among frontline health care workers in Amhara Region, Ethiopia: A cross-sectional survey
April 29, 2021 Seyfe Asrade Atnafie, Demssie Ayalew Anteneh, Dawit Kumilachew Yimenu, Zemene Demelash Kifle

Background: The burden to fight with Corona Virus Disease-19 (COVID-19) pandemic has lied to frontline health care workers that are putting…
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Fig 3. The pooled male to female CFRR (for seven countries) by age group together with the 95% CI lower and upper limits, derived from the meta-analysis. by Green et al., CC BY 4.0

PLOS ONE Sex differences in the case-fatality rates for COVID-19—A comparison of the age-related differences and consistency over seven countries
April 29, 2021 Manfred S. Green, Dorit Nitzan, Naama Schwartz, Yaron Niv, Victoria Peer

Background: Early in the COVID-19 pandemic, it was noted that males seemed to have higher case-fatality rates than females. We examined the…
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Fig 3. Serum Krebs von den lungen (KL-6) levels in patients with abnormal CT scans at 12 weeks. by Arnold et al., CC BY 4.0

PLOS ONE Krebs von den Lungen 6 (KL-6) as a marker for disease severity and persistent radiological abnormalities following COVID-19 infection at 12 weeks
April 29, 2021 David T. Arnold, Charmaine Donald, Max Lyon, Fergus W. Hamilton, Anna J. Morley, Marie Attwood, Alexandra Dipper, Shaney L. Barratt

Introduction: Acute presentations of COVID-19 infection vary, ranging from asymptomatic carriage through to severe clinical manifestations…
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Fig 1. Age distribution of patients stratified by clinical outcome. by Salto-Alejandre et al., CC BY 4.0

PLOS ONE Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study
April 29, 2021 Sonsoles Salto-Alejandre, Silvia Jiménez-Jorge, Nuria Sabé, Antonio Ramos-Martínez, Laura Linares, Maricela Valerio, Pilar Martín-Dávila, Mario Fernández-Ruiz, María Carmen Fariñas, Marino Blanes-Juliá, Elisa Vidal, Zaira R. Palacios-Baena, Román Hernández-Gallego, Jordi Carratalá, Jorge Calderón-Parra, María Ángeles Marcos, Patricia Muñoz, Jesús Fortún-Abete, José María Aguado, Francisco Arnaiz-Revillas, Rosa Blanes-Hernández, Julián de la Torre-Cisneros, Luis E. López-Cortés, Elena García de Vinuesa-Calvo, Clara M. Rosso, Jerónimo Pachón, Javier Sánchez-Céspedes, Elisa Cordero, on behalf of The COVIDSOT Working Team

The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Two original observations concerning bacterial infections in COVID-19 patients hospitalized in intensive care units during the first wave of the epidemic in France
April 29, 2021 Camille d’Humières, Juliette Patrier, Brice Lortat-Jacob, Alexy Tran-dinh, Lotfi Chemali, Naouale Maataoui, Emilie Rondinaud, Etienne Ruppé, Charles Burdet, Stéphane Ruckly, Philippe Montravers, Jean-François Timsit, Laurence Armand-Lefevre

Among 197 COVID-19 patients hospitalized in ICU, 88 (44.7%) experienced at least one bacterial infection, with pneumonia (39.1%) and…
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Fig 2. Patients working in a vital profession (A) and in the medical sector (B) in the SARS-Cov-2 positive-tested, negative-tested, and control groups. by van der Valk et al., CC BY 4.0

PLOS ONE Case-control study of patient characteristics, knowledge of the COVID-19 disease, risk behaviour and mental state in patients visiting an emergency room with COVID-19 symptoms in the Netherlands
April 28, 2021 J. P. M. van der Valk, F. W. J. Heijboer, H. van Middendorp, A. W. M. Evers, J. C. C. M. in ‘t Veen

Background: Coronavirus disease 2019 is a serious respiratory virus pandemic. Patient characteristics, knowledge of the COVID-19 disease,…
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Fig 1. Comparison of Genalyte target-specific results with Beckman and DiaSorin results. by Ikegami et al., CC BY 4.0

PLOS ONE Target specific serologic analysis of COVID-19 convalescent plasma
April 28, 2021 Sachie Ikegami, Robert C. Benirschke, Hossein Fakhrai-Rad, Mohammad H. Motamedi, Rick Hockett, Sean David, Hong Kee Lee, Jason Kang, Thomas J. Gniadek

This study compared the performance of four serology assays for Coronavirus Disease 2019 (COVID-19) and investigated whether COVID-19…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Pathological findings in organs and tissues of patients with COVID-19: A systematic review
April 28, 2021 Sasha Peiris, Hector Mesa, Agnes Aysola, Juan Manivel, Joao Toledo, Marcio Borges-Sa, Sylvain Aldighieri, Ludovic Reveiz

Background: Coronavirus disease (COVID-19) is the pandemic caused by SARS-CoV-2 that has caused more than 2.2 million deaths worldwide. We…
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Fig 1. Daily hospitalization incidence (rate per million population per day) in the absence of vaccination for varying level of public policy response, 2020–2022. by Coudeville et al., CC BY 4.0

PLOS ONE Potential impact of introducing vaccines against COVID-19 under supply and uptake constraints in France: A modelling study
April 28, 2021 Laurent Coudeville, Ombeline Jollivet, Cedric Mahé, Sandra Chaves, Gabriela B. Gomez

Background: The accelerated vaccine development in response to the COVID-19 pandemic should lead to a vaccine being available early 2021,…
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Fig 1. Blood donor demographics of NYC metro area. by Jin et al., CC BY 4.0

PLOS ONE Seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of New York City metro blood donors using multiple SARS-CoV-2 serological assays: Implications for controlling the epidemic and “Reopening”
April 28, 2021 Daniel K. Jin, Daniel J. Nesbitt, Jenny Yang, Haidee Chen, Julie Horowitz, Marcus Jones, Rianna Vandergaast, Timothy Carey, Samantha Reiter, Stephen J. Russell, Christos Kyratsous, Andrea Hooper, Jennifer Hamilton, Manuel Ferreira, Sarah Deng, Donna Straus, Aris Baras, Christopher D. Hillyer, Larry L. Luchsinger

Projections of the stage of the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic and local, regional and national…
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thanksgiving dinner-45.jpg by barbbarbbarb, CC BY 2.0

PLOS ONE Investigation of SARS-CoV-2 infection in dogs and cats of humans diagnosed with COVID-19 in Rio de Janeiro, Brazil
April 28, 2021 Guilherme Amaral Calvet, Sandro Antonio Pereira, Maria Ogrzewalska, Alex Pauvolid-Corrêa, Paola Cristina Resende, Wagner de Souza Tassinari, Anielle de Pina Costa, Lucas Oliveira Keidel, Alice Sampaio Barreto da Rocha, Michele Fernanda Borges da Silva, Shanna Araujo dos Santos, Ana Beatriz Machado Lima, Isabella Campos Vargas de Moraes, Artur Augusto Velho Mendes Junior, Thiago das Chagas Souza, Ezequias Batista Martins, Renato Orsini Ornellas, Maria Lopes Corrêa, Isabela Maria da Silva Antonio, Lusiele Guaraldo, Fernando do Couto Motta, Patrícia Brasil, Marilda Mendonça Siqueira, Isabella Dib Ferreira Gremião, Rodrigo Caldas Menezes

Background: Infection by SARS-CoV-2 in domestic animals has been related to close contact with humans diagnosed with COVID-19. Objectives:…
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Fig 2. by Chen et al., CC BY 4.0

PLOS ONE Hypertension as a sequela in patients of SARS-CoV-2 infection
April 28, 2021 Ganxiao Chen, Xun Li, Zuojiong Gong, Hao Xia, Yao Wang, Xuefen Wang, Yan Huang, Hector Barajas-Martinez, Dan Hu

Background: COVID-19 is a respiratory infectious disease caused by SARS-CoV-2, and cardiovascular damage is commonly observed in affected…
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Fig 3. SARS-CoV-2 mutants with one or two mildly deleterious mutations are expected to exist at high numbers. by Van Egeren et al., CC BY 4.0

PLOS ONE Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
April 28, 2021 Debra Van Egeren, Alexander Novokhodko, Madison Stoddard, Uyen Tran, Bruce Zetter, Michael Rogers, Bradley L. Pentelute, Jonathan M. Carlson, Mark Hixon, Diane Joseph-McCarthy, Arijit Chakravarty

The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics…
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Fig 1. The association of inflammatory markers with death and ICU admission in men and women with COVID-19 infection. by Lau et al., CC BY 4.0

PLOS ONE Sex differences in inflammatory markers in patients hospitalized with COVID-19 infection: Insights from the MGH COVID-19 patient registry
April 28, 2021 Emily S. Lau, Jenna N. McNeill, Samantha M. Paniagua, Elizabeth E. Liu, Jessica K. Wang, Ingrid V. Bassett, Caitlin A. Selvaggi, Steven A. Lubitz, Andrea S. Foulkes, Jennifer E. Ho

Background: Men are at higher risk for serious complications related to COVID-19 infection than women. More robust immune activation in…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Willingness to vaccinate against COVID-19 among Bangladeshi adults: Understanding the strategies to optimize vaccination coverage
April 27, 2021 Minhazul Abedin, Mohammad Aminul Islam, Farah Naz Rahman, Hasan Mahmud Reza, Mohammad Zakir Hossain, Mohammad Anwar Hossain, Adittya Arefin, Ahmed Hossain

Background: Although the approved COVID-19 vaccine has been shown to be safe and effective, mass vaccination in Bangladeshi people remains…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS Pathogens Individuals cannot rely on COVID-19 herd immunity: Durable immunity to viral disease is limited to viruses with obligate viremic spread
April 26, 2021 Jonathan W. Yewdell

…
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Fig 1. Epidemiological characteristics of COVID-19 in Africa. by Lamptey et al., CC BY 4.0

PLOS Neglected Tropical Diseases Genomic and epidemiological characteristics of SARS-CoV-2 in Africa
April 26, 2021 Jones Lamptey, Favour Oluwapelumi Oyelami, Michael Owusu, Bernard Nkrumah, Paul Oluwagbenga Idowu, Enoch Appiah Adu-Gyamfi, Armin Czika, Philip El-Duah, Richmond Yeboah, Augustina Sylverken, Oluwatayo Israel Olasunkanmi, Ellis Owusu-Dabo, Christian Drosten, Yaw Adu-Sarkodie

Since late 2019, the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, has rapidly evolved to become a global pandemic.…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS Neglected Tropical Diseases Distinguishing non severe cases of dengue from COVID-19 in the context of co-epidemics: A cohort study in a SARS-CoV-2 testing center on Reunion island
April 26, 2021 Antoine Joubert, Fanny Andry, Antoine Bertolotti, Frédéric Accot, Yatrika Koumar, Florian Legrand, Patrice Poubeau, Rodolphe Manaquin, Patrick Gérardin, Cécile Levin

Background: As coronavirus 2019 (COVID-19) is spreading globally, several countries are handling dengue epidemics. As both infections are…
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Fig 1. Number of deaths in 2020 according to age class. by Costantino et al., CC BY 4.0

PLOS ONE Utility of hospitalization for elderly individuals affected by COVID-19
April 26, 2021 Giorgio Costantino, Monica Solbiati, Silvia Elli, Marco Paganuzzi, Didi Massabò, Nicola Montano, Marta Mancarella, Francesca Cortellaro, Emanuela Cataudella, Andrea Bellone, Nicolò Capsoni, Guido Bertolini, Giovanni Nattino, Giovanni Casazza

Background: During the COVID-19 pandemic, the number of individuals needing hospital admission has sometimes exceeded the availability of…
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Fig 2. Fitted logistic curves of daily COVID-19 infections for Ireland, Germany, UK, South Korea and Iceland. by Wu et al., CC BY 4.0

PLOS ONE Correlation of national and healthcare workers COVID-19 infection data; implications for large-scale viral testing programs
April 23, 2021 Dan Wu, Pól Mac Aonghusa, Donal F. O’Shea

Time analysis of the course of an infectious disease epidemic is a critical way to understand the dynamics of pathogen transmission and…
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Fig 1. by Derington et al., CC BY 4.0

PLOS ONE Angiotensin II receptor blocker or angiotensin-converting enzyme inhibitor use and COVID-19-related outcomes among US Veterans
April 23, 2021 Catherine G. Derington, Jordana B. Cohen, April F. Mohanty, Tom H. Greene, James Cook, Jian Ying, Guo Wei, Jennifer S. Herrick, Vanessa W. Stevens, Barbara E. Jones, Libo Wang, Alexander R. Zheutlin, Andrew M. South, Thomas C. Hanff, Steven M. Smith, Rhonda M. Cooper-DeHoff, Jordan B. King, G. Caleb Alexander, Dan R. Berlowitz, Faraz S. Ahmad, M. Jason Penrod, Rachel Hess, Molly B. Conroy, James C. Fang, Michael A. Rubin, Srinivasan Beddhu, Alfred K. Cheung, Weiming Xian, William S. Weintraub, Adam P. Bress

Background: Angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) may positively or negatively…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS ONE Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review
April 22, 2021 Lemi Belay Tolu, Alex Ezeh, Garumma Tolu Feyissa

Introduction: The evidence for vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is not well…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS ONE Prevalence, clinical features, and outcomes of SARS-CoV-2 infection in pregnant women with or without mild/moderate symptoms: Results from universal screening in a tertiary care center in Mexico City, Mexico
April 22, 2021 J. Arturo Cardona-Pérez, Isabel Villegas-Mota, A. Cecilia Helguera-Repetto, Sandra Acevedo-Gallegos, Mario Rodríguez-Bosch, Mónica Aguinaga-Ríos, Irma Coronado-Zarco, Moisés León-Juárez, Diana Aguilar-Ayala, María Yolotzin Valdespino-Vázquez, Elsa Romelia Moreno-Verduzco, María Antonieta Rivera, Carolina Valencia-Contreras, María de Lourdes Gómez-Sousa, Mario Solis-Paredes, Brenda Frías-Madrid, César Velasco-Téllez, Juan Carlos Rodriguez-Aldama, Valeria Avila-Sosa, Rafael Galván-Contreras, Ricardo Figueroa-Damian, Manuel Cortés-Bonilla, Guadalupe Estrada-Gutierrez, Salvador Espino-y-Sosa, Claudine Irles

The perinatal consequences of SARS-CoV-2 infection are still largely unknown. This study aimed to describe the features and outcomes of…
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Fig 1. Model flow chart. by Tsoungui Obama et al., CC BY 4.0

PLOS ONE Preventing COVID-19 spread in closed facilities by regular testing of employees—An efficient intervention in long-term care facilities and prisons?
April 22, 2021 Henri Christian Junior Tsoungui Obama, Nessma Adil Mahmoud Yousif, Looli Alawam Nemer, Pierre Marie Ngougoue Ngougoue, Gideon Akumah Ngwa, Miranda Teboh-Ewungkem, Kristan Alexander Schneider

Background: Different levels of control measures were introduced to contain the global COVID-19 pandemic, many of which have been…
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Fig 1. Seroprevalence of COVID-19 in the military police of Rio Grande do Sul. by Pasqualotto et al., CC BY 4.0

PLOS ONE COVID-19 seroprevalence in military police force, Southern Brazil
April 22, 2021 Alessandro C. Pasqualotto, Paula de Castro Pereira, Daiane F. Dalla Lana, Alexandre V. Schwarzbold, Marco S. Ribeiro, Cezar V. W. Riche, Cristiani Pilati P. Castro, Paula L. Korsack, Paulo Emilio B. Ferreira, Guilherme de C. Domingues, Giorgia T. Ribeiro, Marcelo Carneiro, Cassia Ferreira B. Caurio, Izadora Clezar da S. Vasconcellos, Lidiana M. Knebel, Lucas Zamberlan, Andressa P. Stolz, Macarthur Vilanova, Guilherme Watte, Antonio N. Kalil

Background: Limited data is available regarding the frequency of COVID-19 in populations that are highly exposed to SARS-CoV-2. In this…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS ONE SARS-CoV-2 testing strategy: A comparison of restricted and extended strategies in a Swiss outpatient cohort from the community and hospital employees
April 22, 2021 Stéphanie Baggio, Hervé Spechbach, Nathalie Vernaz, Idris Guessous, Laurent Gétaz, Laurent Kaiser, François Chappuis, Julien Salamun, Frédérique Jacquerioz

Background: Testing is a key measure to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we…
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Fig 2. Groups of susceptible and immunized individuals. by Adil Mahmoud Yousif et al., CC BY 4.0

PLOS ONE The impact of COVID-19 vaccination campaigns accounting for antibody-dependent enhancement
April 22, 2021 Nessma Adil Mahmoud Yousif, Henri Christian Junior Tsoungui Obama, Yvan Jordan Ngucho Mbeutchou, Sandy Frank Kwamou Ngaha, Loyce Kayanula, George Kamanga, Toheeb Babatunde Ibrahim, Patience Bwanu Iliya, Sulyman Iyanda, Looli Alawam Nemer, Kristina Barbara Helle, Miranda Ijang Teboh-Ewungkem, Kristan Alexander Schneider

Background: COVID-19 vaccines are approved, vaccination campaigns are launched, and worldwide return to normality seems within close reach.…
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Fig 3. Screening cascade for the progression of hit molecules. by Choi et al., CC BY 4.0

PLOS ONE High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity
April 22, 2021 Ryan Choi, Mowei Zhou, Roger Shek, Jesse W. Wilson, Logan Tillery, Justin K. Craig, Indraneel A. Salukhe, Sarah E. Hickson, Neeraj Kumar, Rhema M. James, Garry W. Buchko, Ruilian Wu, Sydney Huff, Tu-Trinh Nguyen, Brett L. Hurst, Sara Cherry, Lynn K. Barrett, Jennifer L. Hyde, Wesley C. Van Voorhis

SARS-CoV-2 has caused a global pandemic, and has taken over 1.7 million lives as of mid-December, 2020. Although great progress has been…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Clinical characteristics and outcomes of patients with Corona Virus Disease 2019 (COVID-19) at Mercy Health Hospitals, Toledo, Ohio
April 22, 2021 Muhammad Shayan Khan, Ratika Dogra, Leela K. V. Miriyala, F. N. U. Salman, Rizwan Ishtiaq, Dilnoor K. Patti, Aakash Kumar, Gaurav Sandho, Karim Jacob, Kritika Luthra, Ravina Sharma, Rekha Ravikumar, Dharmakaruna Edara, Shanti Pittampalli, Divya Sood, Vinod Khatri, Vijay Mahajan, Salil Avasthi, Arlette Auoad, Srinivas Katragadda

Importance: The ongoing pandemic of the novel Corona Virus Disease 2019 (COVID-19) is an unprecedented challenge to global health, never…
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Untitled by Moghadas et al., CC BY 4.0

PLOS Biology Evaluation of COVID-19 vaccination strategies with a delayed second dose
April 21, 2021 Seyed M. Moghadas, Thomas N. Vilches, Kevin Zhang, Shokoofeh Nourbakhsh, Pratha Sah, Meagan C. Fitzpatrick, Alison P. Galvani

Two of the Coronavirus Disease 2019 (COVID-19) vaccines currently approved in the United States require 2 doses, administered 3 to 4 weeks…
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Fig 1. Flowchart of the article screening and selection process. by Wang et al., CC BY 4.0

PLOS ONE The proportion and effect of corticosteroid therapy in patients with COVID-19 infection: A systematic review and meta-analysis
April 21, 2021 Junning Wang, Weixia Yang, Puwen Chen, Jianbin Guo, Rui Liu, Pengfei Wen, Kun Li, Yao Lu, Tao Ma, Xiaoli Li, Siqing Qin, Yumin Zhang, Yakang Wang

Objectives: Coronavirus disease 2019 (COVID-19) remains a global challenge. Corticosteroids constitute a group of anti-inflammatory and…
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Fig 2. Chest radiographs (CXRs) of an initially asymptomatic patient. by Kim et al., CC BY 4.0

PLOS ONE COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load
April 21, 2021 Cherry Kim, Wooil Kim, Ji Hoon Jeon, Hyeri Seok, Sun Bean Kim, Hee Kyoung Choi, Young Kyung Yoon, Joon Young Song, Dae Won Park, Jang Wook Sohn, Won Suk Choi

Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to…
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Fig 1. Basic reproductive number (R₀) estimates across United States counties. by Sy et al., CC BY 4.0

PLOS ONE Population density and basic reproductive number of COVID-19 across United States counties
April 21, 2021 Karla Therese L. Sy, Laura F. White, Brooke E. Nichols

The basic reproductive number (R0) is a function of contact rates among individuals, transmission probability, and duration of…
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Fig 2. Plot dispersion of Perme Mobility Index (PMI)–ΔPerme Score and the ICU LOS of each included patient (open circle represents patients under 60 years of age and closed circle represents patients above or equal 60 years of age). by Timenetsky et al., CC BY 4.0

PLOS ONE The Perme Mobility Index: A new concept to assess mobility level in patients with coronavirus (COVID-19) infection
April 21, 2021 Karina Tavares Timenetsky, Ary Serpa Neto, Ana Carolina Lazarin, Andreia Pardini, Carla Regina Sousa Moreira, Thiago Domingos Corrêa, Raquel Afonso Caserta Eid, Ricardo Kenji Nawa

Introduction: The Coronavirus Disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. Data on the mobility level of patients with…
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Fig 1. Epidemic curve showing cases of COVID-19 in Blaine County, Idaho residents by date of illness onset (n = 447). by Dunne et al., CC BY 4.0

PLOS ONE Investigation and public health response to a COVID-19 outbreak in a rural resort community—Blaine County, Idaho, 2020
April 21, 2021 Eileen M. Dunne, Tanis Maxwell, Christina Dawson-Skuza, Matthew Burns, Christopher Ball, Kathryn Turner, Christine G. Hahn, Melody Bowyer, Kris K. Carter, Logan Hudson

Blaine County, Idaho, a rural area with a renowned resort, experienced a COVID-19 outbreak early in the pandemic. We undertook an…
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Fig 1. Research framework of the study. by Ramatillah and Isnaini, CC BY 4.0

PLOS ONE Treatment profiles and clinical outcomes of COVID-19 patients at private hospital in Jakarta
April 16, 2021 Diana Laila Ramatillah, Suri Isnaini

Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a virus that causes COVID-19, which has become a worldwide…
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Fig 1. by Doghish et al., CC BY 4.0

PLOS ONE Clinical characteristics of Egyptian male patients with COVID‐19 acute respiratory distress syndrome
April 16, 2021 Ahmed S. Doghish, Walid F. Elkhatib, Essam A. Hassan, Ahmed F. Elkhateeb, Eman E. Mahmoud, Mona I. Ahmed, Mahmoud A. F. Khalil

Background: Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
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Fig 1. Flow cytometric analysis of peripheral blood NK cell subsets and receptors in COVID-19 patients. by Bozzano et al., CC BY 4.0

PLOS Pathogens Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease severity
April 16, 2021 Federica Bozzano, Chiara Dentone, Carola Perrone, Antonio Di Biagio, Daniela Fenoglio, Alessia Parodi, Malgorzata Mikulska, Bianca Bruzzone, Daniele Roberto Giacobbe, Antonio Vena, Lucia Taramasso, Laura Nicolini, Nicolò Patroniti, Paolo Pelosi, Angelo Gratarola, Raffaele De Palma, Gilberto Filaci, Matteo Bassetti, Andrea De Maria, on behalf of GECOVID study group

The SARS-CoV-2 infection causes severe respiratory involvement (COVID-19) in 5–20% of patients through initial immune derangement,…
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Fig 1. Epidemiological description of SARS-CoV-2 in the Colombian Amazonas department. by Ballestros et al., CC BY 4.0

PLOS Neglected Tropical Diseases Deciphering the introduction and transmission of SARS-CoV-2 in the Colombian Amazon Basin
April 15, 2021 Nathalia Ballesteros, Marina Muñoz, Luz Helena Patiño, Carolina Hernández, Felipe González-Casabianca, Iván Carroll, Mauricio Santos-Vega, Jaime Cascante, Andrés Angel, Alejandro Feged-Rivadeneira, Mónica Palma-Cuero, Carolina Flórez, Sergio Gomez, Adriana van de Guchte, Zenab Khan, Jayeeta Dutta, Ajay Obla, Hala Alejel Alshammary, Ana S. Gonzalez-Reiche, Matthew M. Hernandez, Emilia Mia Sordillo, Viviana Simon, Harm van Bakel, Alberto Paniz-M, Juan David Ramírez

Background: The SARS-CoV-2 pandemic has forced health authorities across the world to take important decisions to curtail its spread.…
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Fig 1. Epidemiologic curve of persons under investigation for COVID-19: Frequency by determination date, SARS-CoV-2 test status, and COVID-19 case type, United States, January 17–February 29, 2020 (N = 711). by McGovern et al., CC BY 4.0

PLOS ONE Demographic, clinical, and epidemiologic characteristics of persons under investigation for Coronavirus Disease 2019—United States, January 17–February 29, 2020
April 15, 2021 Olivia L. McGovern, Mark Stenger, Sara E. Oliver, Tara C. Anderson, Cheryl Isenhour, Matthew R. Mauldin, Nia Williams, Eric Griggs, Tonny Bogere, Chris Edens, Aaron T. Curns, Joana Y. Lively, Yingtao Zhou, Songli Xu, Maureen H. Diaz, Jessica L. Waller, Kevin R. Clarke, Mary E. Evans, Elisabeth M. Hesse, Sapna Bamrah Morris, Robert P. McClung, Laura A. Cooley, Naeemah Logan, Andrew T. Boyd, Allan W. Taylor, Kristina L. Bajema, Stephen Lindstrom, Christopher A. Elkins, Christopher Jones, Aron J. Hall, Samuel Graitcer, Alexandra M. Oster, Alicia M. Fry, Marc Fischer, Laura Conklin, Runa H. Gokhale

Background: The Coronavirus Disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2),…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE A qualitative study of the first batch of medical assistance team’s first-hand experience in supporting the nursing homes in Wuhan against COVID-19
April 15, 2021 Xiu-Fen Yang, Meng-qi Li, Lu-lu Liao, Hui Feng, Si Zhao, Shuang Wu, Ping Yin

Background: The pandemic of coronavirus disease 2019 (COVID-19) has global impact, Wuhan in Hubei province is a high-risk area. And the…
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Fig 2. Serum albumin concentrations among patients with and without SARS-CoV-2 antibodies in July 2020. by Anand et al., CC BY 4.0

PLOS ONE Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S.
April 15, 2021 Shuchi Anand, Maria E. Montez-Rath, Jialin Han, Pablo Garcia, Julie Bozeman, Russell Kerschmann, Paul Beyer, Julie Parsonnet, Glenn M. Chertow

Patients on dialysis are at high risk for death due to COVID-19, yet a significant proportion do survive as evidenced by presence of…
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Fig 3. Serum I-FABP correlated with the number of polymorphonuclear cells in COVID-19 patients. by Guedj et al., CC BY 4.0

PLOS ONE I-FABP is decreased in COVID-19 patients, independently of the prognosis
April 15, 2021 Kevin Guedj, Mathieu Uzzan, Damien Soudan, Catherine Trichet, Antonino Nicoletti, Emmanuel Weiss, Hana Manceau, Alexandre Nuzzo, Olivier Corcos, Xavier Treton, Katell Peoc’h

Background: Severe acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) is frequently associated with gastrointestinal…
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Fig 4. Use of the Biomark-based protocol to detect mutations associated with SARS-CoV-2 variants. by JFassy et al., CC BY 4.0

PLOS ONE Versatile and flexible microfluidic qPCR test for high-throughput SARS-CoV-2 and cellular response detection in nasopharyngeal swab samples
April 14, 2021 Julien Fassy, Caroline Lacoux, Sylvie Leroy, Latifa Noussair, Sylvain Hubac, Aurélien Degoutte, Georges Vassaux, Vianney Leclercq, David Rouquié, Charles-Hugo Marquette, Martin Rottman, Patrick Touron, Antoinette Lemoine, Jean-Louis Herrmann, Pascal Barbry, Jean-Louis Nahon, Laure-Emmanuelle Zaragosi, Bernard Mari

The emergence and quick spread of SARS-CoV-2 has pointed at a low capacity response for testing large populations in many countries, in…
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Fig 1. by Ravindra et al., CC BY 4.0

PLOS ONE Impact of COVID-19 on the hospitalization, treatment, and outcomes of intracerebral and subarachnoid hemorrhage in the United States
April 14, 2021 Vijay M. Ravindra, Ramesh Grandhi, Alen Delic, Samuel Hohmann, Ernie Shippey, David Tirschwell, Jennifer A. Frontera, Shadi Yaghi, Jennifer J. Majersik, Mohammad Anadani, Adam de Havenon

Objective: To examine the outcomes of adult patients with spontaneous intracranial and subarachnoid hemorrhage diagnosed with comorbid…
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Fig 1. Proportion of states with high COVID-19 rates among those in the low and high mask adherence quartiles in the preceding month. by Fischer et al., CC BY 4.0

PLOS ONE Mask adherence and rate of COVID-19 across the United States
April 14, 2021 Charlie B. Fischer, Nedghie Adrien, Jeremiah J. Silguero, Julianne J. Hopper, Abir I. Chowdhury, Martha M. Werler

Mask wearing has been advocated by public health officials as a way to reduce the spread of COVID-19. In the United States, policies on…
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Fig 2. Close up of port on scent wheel. by Essler et al., CC BY 4.0

PLOS ONE Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study
April 14, 2021 Jennifer L. Essler, Sarah A. Kane, Pat Nolan, Elikplim H. Akaho, Amalia Z. Berna, Annemarie DeAngelo, Richard A. Berk, Patricia Kaynaroglu, Victoria L. Plymouth, Ian D. Frank, Susan R. Weiss, Audrey R. Odom John, Cynthia M. Otto

While the world awaits a widely available COVID-19 vaccine, availability of testing is limited in many regions and can be further…
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Novel Coronavirus SARS-Cov-2 by NIAID, CC-0 Public Domain

PLOS ONE Low risk of SARS-CoV-2 in blood transfusion
April 13, 2021 Michael Owusu, Augustina Angelina Sylverken, Philip El-Duah, Nana Kwame Ayisi-Boateng, Richmond Yeboah, Eric Adu, Jesse Asamoah, Michael Frimpong, Japhet Senyo, Godfred Acheampong, Mohamed Mutocheluh, John Amuasi, Ellis Owusu-Dabo, Yaw Adu-Sarkodie, Richard Odame Phillips

Background: The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2),…
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Fig 1. Viral copies and Ct values in mask and NPS samples. by Sriraman et al., CC BY 4.0

PLOS ONE Non-invasive adapted N-95 mask sampling captures variation in viral particles expelled by COVID-19 patients: Implications in understanding SARS-CoV2 transmission
April 12, 2021 Kalpana Sriraman, Ambreen Shaikh, Swapneil Parikh, Shreevatsa Udupa, Nirjhar Chatterjee, Jayanthi Shastri, Nerges Mistry

Infectious respiratory particles expelled by SARS-CoV-2 positive patients are attributed to be the key driver of COVID-19 transmission.…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Knowledge, preventive behaviors and risk perception of the COVID-19 pandemic: A cross-sectional study in Turkish health care workers
April 9, 2021 Tufan Arslanca, Cihan Fidan, Mine Daggez, Polat Dursun

The coronavirus disease 2019 (COVID-19) outbreak spread to over 100 countries with a total of 100,000 cases during the first week of March…
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Fig 2. by Rasmussen et al., CC BY 4.0

PLOS ONE SARS-CoV-2 infection dynamics in Denmark, February through October 2020: Nature of the past epidemic and how it may develop in the future
April 9, 2021 Steen Rasmussen, Michael Skytte Petersen, Niels Høiby

Background: Initially, the relative sizes of the asymptomatic and the symptomatic infected populations were not known for the COVID-19…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Similar incidence of coronavirus disease 2019 (COVID-19) in patients with rheumatic diseases with and without hydroxychloroquine therapy
April 8, 2021 Juan Macías, Paz González-Moreno, Esther Sánchez-García, Ramón Morillo-Verdugo, José J. Pérez-Venegas, Ana Pinilla, MªMar Macho, MªVictoria Martínez, Alejandro González-Serna, Anaïs Corma, Luis M. Real, Juan A. Pineda

Background: Hydroxychloroquine is not efficacious as post-exposure prophylaxis against coronavirus disease 2019 (COVID-19). It is not known…
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Fig 2. Distribution of ordinal scale on day one, prior to treatment, day 14, and day 28. by Mehta et al., CC BY 4.0

PLOS ONE What about tocilizumab? A retrospective study from a NYC Hospital during the COVID-19 outbreak
April 8, 2021 Monica Mehta, Lawrence J. Purpura, Thomas H. McConville, Matthew J. Neidell, Michaela R. Anderson, Elana J. Bernstein, Donald E. Dietz, Justin Laracy, Shauna H. Gunaratne, Emily Happy Miller, Jennifer Cheng, Jason Zucker, Shivang S. Shah, Shaoli Chaudhuri, Christian A. Gordillo, Shreena R. Patel, Tai Wei Guo, Lara E. Karaaslan, Ran Reshef, Benjamin A. Miko, Joan M. Bathon, Marcus R. Pereira, Anne-Catrin Uhlemann, Michael T. Yin, Magdalena E. Sobieszczyk

Background: Tocilizumab, an interleukin-6 receptor blocker, has been used in the inflammatory phase of COVID-19, but its impact independent…
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Fig 1. Map of a portion of the underground sewer pipeline network of Belmont, Massachusetts (thanks to PeopleGIS for granting permission to publish this MapsOnline site.). by Nourinejad et al., CC BY 4.0

PLOS ONE Placing sensors in sewer networks: A system to pinpoint new cases of coronavirus
April 8, 2021 Mehdi Nourinejad, Oded Berman, Richard C. Larson

We consider a proposed system that would place sensors in a number of wastewater manholes in a community in order to detect genetic…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Prevalence of SARS-COV-2 positivity in 516 German intensive care and emergency physicians studied by seroprevalence of antibodies National Covid Survey Germany (NAT-COV-SURV)
April 8, 2021 Detlef Kindgen-Milles, Timo Brandenburger, Julian F. W. Braun, Corvin Cleff, Kian Moussazadeh, Ingo Mrosewski, Jörg Timm, Dietmar Wetzchewald

Healthcare personnel are at risk to aquire the corona virus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome…
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Fig 1. Days from admission to the appearance of neurologic events. by Flores-Silva et al., CC BY 4.0

PLOS ONE Neurologic manifestations in hospitalized patients with COVID-19 in Mexico City
April 8, 2021 Fernando Daniel Flores-Silva, Miguel García-Grimshaw, Sergio Iván Valdés-Ferrer, Alma Poema Vigueras-Hernández, Rogelio Domínguez-Moreno, Dioselina Panamá Tristán-Samaniego, Anaclara Michel-Chávez, Alejandra González-Duarte, Felipe A. Vega-Boada, Isael Reyes-Melo, Amado Jiménez-Ruiz, Oswaldo Alan Chávez-Martínez, Daniel Rebolledo-García, Osvaldo Alexis Marché-Fernández, Samantha Sánchez-Torres, Guillermo García-Ramos, Carlos Cantú-Brito, Erwin Chiquete

Background: The coronavirus disease 2019 (COVID-19) is a systemic entity that frequently implies neurologic features at presentation and…
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Fig 2. Antigen kinetics determined for specimens from 38 COVID-19 patients at different post-symptom-onset periods assessed by two antigen assays according to cut-off index values, the AFIAS COVID-19 Ag and the ichroma^TM COVID-19 Ag. by Kweon et al., CC BY 4.0

PLOS ONE Evaluation of rapid SARS-CoV-2 antigen tests, AFIAS COVID-19 Ag and ichroma COVID-19 Ag, with serial nasopharyngeal specimens from COVID-19 patients
April 8, 2021 Oh Joo Kweon, Yong Kwan Lim, Hye Ryoun Kim, Yoojeong Choi, Min-Chul Kim, Seong-Ho Choi, Jin-Won Chung, Mi-Kyung Lee

We evaluated the diagnostic accuracy of two newly developed, point-of-care, rapid antigen tests (RATs) for detecting SARS-CoV-2, the AFIAS…
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Fig 2. Comparison of COVID-19 and post-COVID-19 symptoms. by Mahmud et al., CC BY 4.0

PLOS ONE Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary care center of Bangladesh
April 8, 2021 Reaz Mahmud, Md. Mujibur Rahman, Mohammad Aftab Rassel, Farhana Binte Monayem, S. K. Jakaria Been Sayeed, Md. Shahidul Islam, Mohammed Monirul Islam

Background: Post-coronavirus disease (COVID-19) syndrome includes persistence of symptoms beyond viral clearance and fresh development of…
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Fig 1. Comparative assessment of 168 serum samples from SARS-CoV-2-infected individuals by ELISA and lateral flow immunoassay. by Sweeney et al., CC BY 4.0

PLOS ONE Clinical utility of targeted SARS-CoV-2 serology testing to aid the diagnosis and management of suspected missed, late or post-COVID-19 infection syndromes: Results from a pilot service implemented during the first pandemic wave
April 7, 2021 Nicola Sweeney, Blair Merrick, Rui Pedro Galão, Suzanne Pickering, Alina Botgros, Harry D. Wilson, Adrian W. Signell, Gilberto Betancor, Mark Kia Ik Tan, John Ramble, Neophytos Kouphou, Sam Acors, Carl Graham, Jeffrey Seow, Eithne MacMahon, Stuart J. D. Neil, Michael H. Malim, Katie Doores, Sam Douthwaite, Rahul Batra, Gaia Nebbia, Jonathan D. Edgeworth

During the first wave of the global COVID-19 pandemic the clinical utility and indications for SARS-CoV-2 serological testing were not…
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Fig 1. Odd ratio of A (red square) and O group (green circle) from our study and the ones found in the literature. by Muñoz-Culla et al., CC BY 4.0

PLOS ONE O group is a protective factor for COVID19 in Basque population
April 7, 2021 Maider Muñoz-Culla, Andres Roncancio-Clavijo, Bruno Martínez, Miriam Gorostidi-Aicua, Luis Piñeiro, Arkaitz Azkune, Ainhoa Alberro, Jorge Monge-Ruiz, Tamara Castillo-Trivino, Alvaro Prada, David Otaegui

ABO blood groups have recently been related to COVID19 infection. In the present work, we performed this analysis using data from 412…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Association of ABO blood groups with presentation and outcomes of confirmed SARS CoV-2 infection: A prospective study in the largest COVID-19 dedicated hospital in Bangladesh
April 7, 2021 Reaz Mahmud, Mohammad Aftab Rassel, Farhana Binte Monayem, S. K. Jakaria Been Sayeed, Md Shahidul Islam, Mohammed Monirul Islam, Mohammad Abdullah Yusuf, Sabrina Rahman, K. M. Nazmul Islam, Imran Mahmud, Mohammad Zaid Hossain, Ahmed Hossain Chowdhury, A. K. M. Humayon Kabir, Kazi Gias Uddin Ahmed, Md. Mujibur Rahman

Background: Globally, studies have shown conflicting results regarding the association of blood groups with SARS CoV-2 infection.…
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Fig 3. SARS-CoV-2 intrahost single nucleotide variant (iSNV) diversity. by Valesano et al., CC BY 4.0

PLOS Pathogens Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts
April 7, 2021 Andrew L. Valesano, Kalee E. Rumfelt, Derek E. Dimcheff, Christopher N. Blair, William J. Fitzsimmons, Joshua G. Petrie, Emily T. Martin, Adam S. Lauring

Analysis of SARS-CoV-2 genetic diversity within infected hosts can provide insight into the generation and spread of new viral variants…
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Fig 7. Galbraith plot identified eight outlier studies as potential sources of heterogeneity. by Islam et al., CC BY 4.0

PLOS ONE Prevalence and characteristics of fever in adult and paediatric patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis of 17515 patients
April 6, 2021 Md Asiful Islam, Shoumik Kundu, Sayeda Sadia Alam, Tareq Hossan, Mohammad Amjad Kamal, Rosline Hassan

Background: Coronavirus disease 2019 (COVID-19), a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 started…
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Fig 1. Seroprevalence of antibodies to SARS-CoV-2. by Hiki et al., CC BY 4.0

PLOS ONE Seroprevalence of anti-SARS-CoV-2 antibodies in Japanese COVID-19 patients
April 6, 2021 Makoto Hiki, Yoko Tabe, Tomohiko Ai, Yuya Matsue, Norihiro Harada, Kiichi Sugimoto, Yasushi Matsushita, Masakazu Matsushita, Mitsuru Wakita, Shigeki Misawa, Mayumi Idei, Takashi Miida, Naoto Tamura, Kazuhisa Takahashi, Toshio Naito

Objectives: To determine the seroprevalence of anti-SARS-CoV-2 IgG and IgM antibodies in symptomatic Japanese COVID-19 patients. Methods:…
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Fig 1. Correlation between IL-6 and NLR. by Garcia-Gordillo et al., CC BY 4.0

PLOS ONE COVID-IRS: A novel predictive score for risk of invasive mechanical ventilation in patients with COVID-19
April 5, 2021 José Antonio Garcia-Gordillo, Antonio Camiro-Zúñiga, Mercedes Aguilar-Soto, Dalia Cuenca, Arturo Cadena-Fernández, Latife Salame Khouri, Jesica Naanous Rayek, Moises Mercado, The ARMII Study Group

Background: Coronavirus disease 2019 (COVID-19) is a systemic disease that can rapidly progress into acute respiratory failure and death.…
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Fig 1. Kaplan-Meier curves for cumulative survival probability during hospitalization. by He et al., CC BY 4.0

PLOS ONE Clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection: A multi-center study
April 5, 2021 Shengyang He, Wenlong Liu, Mingyan Jiang, Peng Huang, Zhi Xiang, Dingding Deng, Ping Chen, Lihua Xie

Objective: To understand the clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection (CDBC), and…
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Fig 2. The average Ct value of E, RdRP and ORF 1ab gene in different clinical samples. by Sharma et al., CC BY 4.0

PLOS ONE Comparative analysis of various clinical specimens in detection of SARS-CoV-2 using rRT-PCR in new and follow up cases of COVID-19 infection: Quest for the best choice
April 5, 2021 Kuldeep Sharma, Pragya Aggarwala, Deepa Gandhi, Anuniti Mathias, Priyanka Singh, Somya Sharma, Sanjay Singh Negi, Anudita Bhargava, Padma Das, Ujjwala Gaikwad, Archana Wankhede, Ajoy Behra, Nitin M. Nagarkar

Background: An appropriate specimen is of paramount importance in Real Time reverse transcription-polymerase chain reaction (rRT-PCR) based…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Evaluation of the Abbott BinaxNOW rapid antigen test for SARS-CoV-2 infection in children: Implications for screening in a school setting
April 5, 2021 Neeraj Sood, Rashmi Shetgiri, Anna Rodriguez, Dianna Jimenez, Sonia Treminino, Amanda Daflos, Paul Simon

Background: Rapid antigen tests hold much promise for use in the school environment. However, the performance of these tests in…
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Fig 2. Log-log plot of study seroprevalence (x-axis) vs two cumulative case estimators for each study. by Byambasuren et al., CC BY 4.0

PLOS ONE Comparison of seroprevalence of SARS-CoV-2 infections with cumulative and imputed COVID-19 cases: Systematic review
April 2, 2021 Oyungerel Byambasuren, Claudia C. Dobler, Katy Bell, Diana Patricia Rojas, Justin Clark, Mary-Louise McLaws, Paul Glasziou

Background: Accurate seroprevalence estimates of SARS-CoV-2 in different populations could clarify the extent to which current testing…
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Fig 1. Daily cumulative number of first reported case COVID-19 and school closure. by Nazif-Muñoz et al., CC BY 4.0

PLOS ONE The global viralization of policies to contain the spreading of the COVID-19 pandemic: Analyses of school closures and first reported cases
April 1, 2021 José Ignacio Nazif-Muñoz, Sebastián Peña, Youssef Oulhote

Background: On January 30th 2020, the World Health Organization (WHO) declared a international health emergency due to the unprecedented…
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Fig 1. Numbers of confirmed COVID-19 cases across geographical areas of Thailand as of July 4, 2020. by Nopsopon et al., CC BY 4.0

PLOS ONE Seroprevalence of hospital staff in a province with zero COVID-19 cases
April 1, 2021 Tanawin Nopsopon, Krit Pongpirul, Korn Chotirosniramit, Wutichai Jakaew, Chuenkhwan Kaewwijit, Sawan Kanchana, Narin Hiransuthikul

Background: COVID-19 seroprevalence data, particularly in less developed countries with a relatively low incidence, has been scant. We…
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Fig 1. Ranking of counties based on health indicators. by Bhowmik et al., CC BY 4.0

PLOS ONE A comprehensive analysis of COVID-19 transmission and mortality rates at the county level in the United States considering socio-demographics, health indicators, mobility trends and health care infrastructure attributes
April 1, 2021 Tanmoy Bhowmik, Sudipta Dey Tirtha, Naveen Chandra Iraganaboina, Naveen Eluru

Background: Several research efforts have evaluated the impact of various factors including a) socio-demographics, (b) health indicators,…
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Fig 2. COVID-19 outbreak examples. by Gros et al., CC BY 4.0

PLOS ONE Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities
April 1, 2021 Claudius Gros, Roser Valenti, Lukas Schneider, Benedikt Gutsche, Dimitrije Marković

The distinct ways the COVID-19 pandemic has been unfolding in different countries and regions suggest that local societal and governmental…
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Fig 1. Overview of the proposed diagnostic system for COVID-19. by Han et al., CC BY 4.0

PLOS ONE Semi-supervised learning for an improved diagnosis of COVID-19 in CT images
April 1, 2021 Chang Hee Han, Misuk Kim, Jin Tae Kwak

Coronavirus disease 2019 (COVID-19) has been spread out all over the world. Although a real-time reverse-transcription polymerase chain…
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Fig 1. A weekly timeline of the COVID-19 epidemic. by Kasztelewicz et al., CC BY 4.0

PLOS ONE Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland
April 1, 2021 Beata Kasztelewicz, Katarzyna Janiszewska, Julia Burzyńska, Emilia Szydłowska, Marek Migdał, Katarzyna Dzierżanowska-Fangrat

Data on the prevalence of the SARS-CoV-2 antibody in healthcare workers (HCWs) is scarce, especially in pediatric settings. The purpose of…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS ONE Baseline cardiometabolic profiles and SARS-CoV-2 infection in the UK Biobank
April 1, 2021 Ryan J. Scalsky, Yi-Ju Chen, Karan Desai, Jeffery R. O’Connell, James A. Perry, Charles C. Hong

Background: SARS-CoV-2 is a rapidly spreading coronavirus responsible for the Covid-19 pandemic, which is characterized by severe…
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Fig 1. ROC curves mechanical ventilation prediction (AUC 68%). by Yu et al., CC BY 4.0

PLOS ONE Machine learning methods to predict mechanical ventilation and mortality in patients with COVID-19
April 1, 2021 Limin Yu, Alexandra Halalau, Bhavinkumar Dalal, Amr E. Abbas, Felicia Ivascu, Mitual Amin, Girish B. Nair

Background: The Coronavirus disease 2019 (COVID-19) pandemic has affected millions of people across the globe. It is associated with a high…
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Fig 1. Map showing all health facilities in Bulawayo district and highlighting the 24 sampled health facilities. by Rusakaniko et al., CC BY 4.0

PLOS Neglected Tropical Diseases SARS-CoV-2 Serological testing in frontline health workers in Zimbabwe
March 31, 2021 Simbarashe Rusakaniko, Elopy Nemele Sibanda, Takafira Mduluza, Paradzayi Tagwireyi, Zephaniah Dhlamini, Chiratidzo Ellen Ndhlovu, Precious Chandiwana, Shingirai Chiwambutsa, Rivka May Lim, Fiona Scott, Lindiwe Majele Sibanda, Francisca Mutapi

Background: In order to protect health workers from SARS-CoV-2, there is need to characterise the different types of patient facing health…
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Fig 1. Number of COVID-19 hospitalizations in Belgium (BE) and the Netherlands (NL) including an overview of the national preventive measures taken during first epidemic wave, February-July 2020. by Verberk et al., CC BY 4.0

PLOS ONE Experiences and needs of persons living with a household member infected with SARS-CoV-2: A mixed method study
March 31, 2021 Janneke D. M. Verberk, Sibyl A. Anthierens, Sarah Tonkin-Crine, Herman Goossens, John Kinsman, Marieke L. A. de Hoog, Julia A. Bielicki, Patricia C. J. L. Bruijning-Verhagen, Nina H. Gobat

Background: Households are important sites for transmission of SARS-CoV-2 and preventive measures are recommended. This study aimed to 1)…
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Fig 1. Score plot: PC2 vs. PC1. by Lusczek et al., CC BY 4.0

PLOS ONE Characterizing COVID-19 clinical phenotypes and associated comorbidities and complication profiles
March 31, 2021 Elizabeth R. Lusczek, Nicholas E. Ingraham, Basil S. Karam, Jennifer Proper, Lianne Siegel, Erika S. Helgeson, Sahar Lotfi-Emran, Emily J. Zolfaghari, Emma Jones, Michael G. Usher, Jeffrey G. Chipman, R. Adams Dudley, Bradley Benson, Genevieve B. Melton, Anthony Charles, Monica I. Lupei, Christopher J. Tignanelli

Purpose: Heterogeneity has been observed in outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19). Identification of…
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Fig 1. Study model. by Feldman et al., CC BY 4.0

PLOS ONE Endotracheal intubation of COVID-19 patients by paramedics using a box barrier: A randomized crossover manikin study
March 31, 2021 Oren Feldman, Nir Samuel, Noa Kvatinsky, Ravit Idelman, Raz Diamand, Itai Shavit

Background: In the prehospital setting, endotracheal intubation (ETI) may be required to secure the coronavirus disease 2019 (COVID-19)…
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Fig 4. Sunburst diagram of medication pathways with individual regimens grouped by order of initiation. by McPadden et al., CC BY 4.0

PLOS ONE Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
March 31, 2021 Jacob McPadden, Frederick Warner, H. Patrick Young, Nathan C. Hurley, Rebecca A. Pulk, Avinainder Singh, Thomas J. S. Durant, Guannan Gong, Nihar Desai, Adrian Haimovich, Richard Andrew Taylor, Murat Gunel, Charles S. Dela Cruz, Shelli F. Farhadian, Jonathan Siner, Merceditas Villanueva, Keith Churchwell, Allen Hsiao, Charles J. Torre Jr, Eric J. Velazquez, Roy S. Herbst, Akiko Iwasaki, Albert I. Ko, Bobak J. Mortazavi, Harlan M. Krumholz, Wade L. Schulz

Objective: Severe acute respiratory syndrome virus (SARS-CoV-2) has infected millions of people worldwide. Our goal was to identify risk…
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Fig 2. Distribution by age intervals of the patients admitted for COVID-19 during the first and second waves. by Iftimie et al., CC BY 4.0

PLOS ONE First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain
March 31, 2021 Simona Iftimie, Ana F. López-Azcona, Immaculada Vallverdú, Salvador Hernández-Flix, Gabriel de Febrer, Sandra Parra, Anna Hernández-Aguilera, Francesc Riu, Jorge Joven, Natàlia Andreychuk, Gerard Baiges-Gaya, Frederic Ballester, Marc Benavent, José Burdeos, Alba Català, Èric Castañé, Helena Castañé, Josep Colom, Mireia Feliu, Xavier Gabaldó, Diana Garrido, Pedro Garrido, Joan Gil, Paloma Guelbenzu, Carolina Lozano, Francesc Marimon, Pedro Pardo, Isabel Pujol, Antoni Rabassa, Laia Revuelta, Marta Ríos, Neus Rius-Gordillo, Elisabet Rodríguez-Tomàs, Wojciech Rojewski, Esther Roquer-Fanlo, Noèlia Sabaté, Anna Teixidó, Carlos Vasco, Jordi Camps, Antoni Castro

Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with a first wave during…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC BY 4.0

PLOS ONE Functional outcomes in the inpatient rehabilitation setting following severe COVID-19 infection
March 31, 2021 Cameron Spencer Olezene, Elizabeth Hansen, Hannah K. Steere, Joseph T. Giacino, Ginger R. Polich, Joanne Borg-Stein, Ross D. Zafonte, Jeffrey C. Schneider

Objective: To characterize the functional impairments of a cohort of patients undergoing inpatient rehabilitation after surviving severe…
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Untitled by Inbaraj et al., CC BY 4.0

PLOS ONE Seroprevalence of COVID-19 infection in a rural district of South India: A population-based seroepidemiological study
March 31, 2021 Leeberk Raja Inbaraj, Carolin Elizabeth George, Sindhulina Chandrasingh

Objectives: We aimed to estimate the seroprevalence of COVID-19 in a rural district of South India, six months after the index case.…
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Fig 3. by Berger et al., CC BY 4.0

PLOS ONE Diagnostic accuracy of two commercial SARS-CoV-2 antigen-detecting rapid tests at the point of care in community-based testing centers
March 31, 2021 Alice Berger, Marie Therese Ngo Nsoga, Francisco Javier Perez-Rodriguez, Yasmine Abi Aad, Pascale Sattonnet-Roche, Angèle Gayet-Ageron, Cyril Jaksic, Giulia Torriani, Erik Boehm, Ilona Kronig, Jilian A. Sacks, Margaretha de Vos, Frédérique Jacquerioz Bausch, François Chappuis, Adriana Renzoni, Laurent Kaiser, Manuel Schibler, Isabella Eckerle

Objectives: Determine the diagnostic accuracy of two antigen-detecting rapid diagnostic tests (Ag-RDT) for SARS-CoV-2 at the point of care…
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Fig 2. The simulation model structure representing the dynamic interactions of different health state of COVID-19. by Ansah et al., CC BY 4.0

PLOS ONE The effectiveness of public health interventions against COVID-19: Lessons from the Singapore experience
March 30, 2021 John P. Ansah, David Bruce Matchar, Sean Lam Shao Wei, Jenny G. Low, Ahmad Reza Pourghaderi, Fahad Javaid Siddiqui, Tessa Lui Shi Min, Aloysius Chia Wei-Yan, Marcus Eng Hock Ong

Background: In dealing with community spread of COVID-19, two active interventions have been attempted or advocated—containment, and…
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Fig 2. Adherence to behavioral NPIs to mitigate Covid-19 and subsequent mortality increases over three months in eight countries: (A) Percentage of adult population with strong or very strong self-reported adherence on June 1, 2020; (B) Percentage increase in reported Covid-19 mortality from June 1 to August 31, 2020. by Margraf et al., CC BY 4.0

PLOS ONE Adherence to behavioral Covid-19 mitigation measures strongly predicts mortality
March 30, 2021 Jürgen Margraf, Julia Brailovskaia, Silvia Schneider

In the absence of vaccines or causal therapies, behavioral measures such as wearing face masks and maintaining social distance are central…
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Fig 1. Results of the measurement of SARS-CoV-2 RNA standards using the GeneSoC^®. by Watanabe et al., CC BY 4.0

PLOS ONE Evaluation of the basic assay performance of the GeneSoc^® rapid PCR testing system for detection of severe acute respiratory syndrome coronavirus 2
March 30, 2021 Ryosuke Watanabe, Satomi Asai, Hidehumi Kakizoe, Hirofumi Saeki, Atsuko Masukawa, Miki Miyazawa, Kazumi Ohtagawa, Mend-Amar Ravzanaaadii, Mika Doi, Haruyo Atsumi, Kazuo Umezawa, Hayato Miyachi

In the ongoing coronavirus disease 2019 (COVID-19) pandemic, PCR has been widely used for screening patients displaying relevant symptoms.…
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Fig 1. Comparison of sampling into VTM vs. NSLB. by Erster et al., CC BY 4.0

PLOS ONE Improved sensitivity, safety, and rapidity of COVID-19 tests by replacing viral storage solution with lysis buffer
March 30, 2021 Oran Erster, Omer Shkedi, Gil Benedek, Eyal Zilber, Itay Varkovitzky, Rachel Shirazi, Dorit Oriya Shorka, Yuval Cohen, Tzahi Bar, Rafi Yechieli, Michal Tepperberg Oikawa, Dana Venkert, Michal Linial, Esther Oiknine-Djian, Michal Mandelboim, Zvi Livneh, Gilat Shenhav-Saltzman, Ella Mendelson, Dana Wolf, Moran Szwarcwort-Cohen, Orna Mor, Yair Lewis, Danny Zeevi

Conducting numerous, rapid, and reliable PCR tests for SARS-CoV-2 is essential for our ability to monitor and control the current COVID-19…
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Fig 1. ROC curve for lab parameters. by Malik et al., CC BY 4.0

PLOS ONE Thyroid function analysis in COVID-19: A retrospective study from a single center
March 30, 2021 Jahanzeb Malik, Asmara Malik, Muhammad Javaid, Tayyaba Zahid, Uzma Ishaq, Muhammad Shoaib

Background and objective: Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the…
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Fig 1. SARS-CoV and SARS-CoV-2 replication kinetics in hAEC cultures. by V'kovski et al., CC BY 4.0

PLOS Biology Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium
March 29, 2021 Philip V’kovski, Mitra Gultom, Jenna N. Kelly, Silvio Steiner, Julie Russeil, Bastien Mangeat, Elisa Cora, Joern Pezoldt, Melle Holwerda, Annika Kratzel, Laura Laloli, Manon Wider, Jasmine Portmann, Thao Tran, Nadine Ebert, Hanspeter Stalder, Rune Hartmann, Vincent Gardeux, Daniel Alpern, Bart Deplancke, Volker Thiel, Ronald Dijkman

Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major…
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Fig 4. Difference between mean serial and generation intervals and realized incubation periods. by Torneri et al., CC BY 4.0

PLOS Computational Biology On realized serial and generation intervals given control measures: The COVID-19 pandemic case
March 29, 2021 Andrea Torneri, Peter Libin, Gianpaolo Scalia Tomba, Christel Faes, James G. Wood, Niel Hens

The SARS-CoV-2 pathogen is currently spreading worldwide and its propensity for presymptomatic and asymptomatic transmission makes it…
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Fig 2. Contact rate matrix. by Lee et al., CC BY 4.0

PLOS ONE The effect of control measures on COVID-19 transmission in South Korea
March 29, 2021 Taeyong Lee, Hee-Dae Kwon, Jeehyun Lee

Countries around the world have taken control measures to mitigate the spread of COVID-19, including Korea. Social distancing is…
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Untitled by Arias-Reyes et al., CC BY 4.0

PLOS ONE Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent
March 29, 2021 Christian Arias-Reyes, Favio Carvajal-Rodriguez, Liliana Poma-Machicao, Fernanda Aliaga-Raduán, Danuzia A. Marques, Natalia Zubieta-DeUrioste, Roberto Alfonso Accinelli, Edith M. Schneider-Gasser, Gustavo Zubieta-Calleja, Mathias Dutschmann, Jorge Soliz

The coronavirus disease 2019 (COVID-19) outbreak in North, Central, and South America has become the epicenter of the current pandemic. We…
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Fig 1. by Wang et al., CC BY 4.0

PLOS ONE Transmission and control pressure analysis of the COVID-19 epidemic situation using multisource spatio-temporal big data
March 29, 2021 Fangxiong Wang, Ziqian Tan, Zaihui Yu, Siqi Yao, Changfeng Guo

Taking the Guangdong-Hong Kong-Macao Greater Bay Area as the research area, this paper used OD cluster analysis based on Baidu migration…
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Fig 2. SARS-CoV-2 imported and circulating clades. by Zuckerman et al., CC BY 4.0

PLOS ONE Genomic variation and epidemiology of SARS-CoV-2 importation and early circulation in Israel
March 26, 2021 Neta S. Zuckerman, Efrat Bucris, Yaron Drori, Oran Erster, Danit Sofer, Rakefet Pando, Ella Mendelson, Orna Mor, Michal Mandelboim

Severe acute respiratory disease coronavirus 2 (SARS-CoV-2) which causes corona virus disease (COVID-19) was first identified in Wuhan,…
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Fig 2. User interface in the cell phone application observed in the home unit. by Motta et al., CC BY 4.0

PLOS ONE An emergency system for monitoring pulse oximetry, peak expiratory flow, and body temperature of patients with COVID-19 at home: Development and preliminary application
March 26, 2021 Leonardo Pereira Motta, Pedro Paulo Ferreira da Silva, Bruno Max Borguezan, Jorge Luis Machado do Amaral, Lucimar Gonçalves Milagres, Márcio Neves Bóia, Marcos Rochedo Ferraz, Roberto Mogami, Rodolfo Acatauassú Nunes, Pedro Lopes de Melo

Background: COVID-19 is characterized by a rapid change in the patient’s condition, with major changes occurring over a few days. We aimed…
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Fig 2. Cumulative incidence plot of death and recovery in the total population, separated by age group. by Nijman et al., CC BY 4.0

PLOS ONE Risk factors for in-hospital mortality in laboratory-confirmed COVID-19 patients in the Netherlands: A competing risk survival analysis
March 26, 2021 Gerine Nijman, Maike Wientjes, Jordache Ramjith, Nico Janssen, Jacobien Hoogerwerf, Evertine Abbink, Marc Blaauw, Ton Dofferhoff, Marjan van Apeldoorn, Karin Veerman, Quirijn de Mast, Jaap ten Oever, Wouter Hoefsloot, Monique H. Reijers, Reinout van Crevel, Josephine S. van de Maat

Background: To date, survival data on risk factors for COVID-19 mortality in western Europe is limited, and none of the published survival…
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Untitled by Jin et al., CC BY 4.0

PLOS Pathogens Sex- and age-specific clinical and immunological features of coronavirus disease 2019
March 26, 2021 Shengwei Jin, Hui An, Tong Zhou, Ting Li, Mengzhen Xie, Saijing Chen, Chengshui Chen, Binyu Ying, Zhangye Xu, Xiaokun Li, Ming Li

To simultaneously determine clinical and immunological responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection…
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Fig 2. SARS-CoV-2 evolution. by Rolland and Gilbert, CC BY 4.0

PLOS Pathogens Sieve analysis to understand how SARS-CoV-2 diversity can impact vaccine protection
March 25, 2021 Morgane Rolland, Peter B. Gilbert

…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE ICU outcomes and survival in patients with severe COVID-19 in the largest health care system in central Florida
March 25, 2021 Eduardo Oliveira, Amay Parikh, Arnaldo Lopez-Ruiz, Maria Carrilo, Joshua Goldberg, Martin Cearras, Khaled Fernainy, Sonja Andersen, Luis Mercado, Jian Guan, Hammad Zafar, Patricia Louzon, Amy Carr, Natasha Baloch, Richard Pratley, Scott Silverstry, Vincent Hsu, Jason Sniffen, Victor Herrera, Neil Finkler

Background: Observational studies have consistently described poor clinical outcomes and increased ICU mortality in patients with severe…
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Fig 4. SARS-CoV-2 infection risk map (grid) of Rio de Janeiro state, displaying the city of Rio de Janeiro (capital, left) and the city of Niteroi (right). by Dantas et al., CC BY 4.0

PLOS ONE App-based symptom tracking to optimize SARS-CoV-2 testing strategy using machine learning
March 25, 2021 Leila F. Dantas, Igor T. Peres, Leonardo S. L. Bastos, Janaina F. Marchesi, Guilherme F. G. de Souza, João Gabriel M. Gelli, Fernanda A. Baião, Paula Maçaira, Silvio Hamacher, Fernando A. Bozza

Background: Tests are scarce resources, especially in low and middle-income countries, and the optimization of testing programs during a…
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Untitled by Pozderac and Skinner, CC BY 4.0

PLOS ONE Superspreading of SARS-CoV-2 in the USA
March 25, 2021 Calvin Pozderac, Brian Skinner

A number of epidemics, including the SARS-CoV-1 epidemic of 2002-2004, have been known to exhibit superspreading, in which a small…
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Fig 1. Age and sex-stratification of the outcomes (CPAP/NIV, ICU admission, and death) in SARS-CoV-2 patients. by Gili et al., CC BY 4.0

PLOS ONE SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy
March 25, 2021 Tommaso Gili, Giampaolo Benelli, Elisabetta Buscarini, Ciro Canetta, Giuseppe La Piana, Guido Merli, Alessandro Scartabellati, Giovanni Viganò, Roberto Sfogliarini, Giovanni Melilli, Roberto Assandri, Daniele Cazzato, Davide Sebastiano Rossi, Susanna Usai, Guido Caldarelli, Irene Tramacere, Germano Pellegata, Giuseppe Lauria

We report onset, course, correlations with comorbidities, and diagnostic accuracy of nasopharyngeal swab in 539 individuals suspected to…
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Fig 1. Cumulative in-, outpatient and total hospitalization case deficit for several conditions in the German-wide Helios hospital network during the Covid-19 pandemic. by Bollmann et al., CC BY 4.0

PLOS ONE Utilization of in- and outpatient hospital care in Germany during the Covid-19 pandemic insights from the German-wide Helios hospital network
March 25, 2021 Andreas Bollmann, Sven Hohenstein, Vincent Pellissier, Katharina Stengler, Peter Reichardt, Jörg-Peter Ritz, Holger Thiele, Michael A. Borger, Gerhard Hindricks, Andreas Meier-Hellmann, Ralf Kuhlen

Background: During the early phase of the Covid-19 pandemic, reductions of hospital admissions with a focus on emergencies have been…
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cat by Sean MacEntee, CC BY 2.0

PLOS ONE Neutralizing antibodies for SARS-CoV-2 in stray animals from Rio de Janeiro, Brazil
March 25, 2021 Helver Gonçalves Dias, Maria Eduarda Barreto Resck, Gabriela Cardoso Caldas, Alessandro Fioretti Resck, Natália Valente da Silva, Aline Marcele Vieira dos Santos, Thiago das Chagas Sousa, Maria Halina Ogrzewalska, Marilda Mendonça Siqueira, Alex Pauvolid-Corrêa, Flavia Barreto dos Santos

The epidemic of coronavirus disease 2019 (COVID-19), caused by a novel Betacoronavirus named severe acute respiratory syndrome coronavirus…
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Fig 1. Vaccine constructs and vaccination schedule. by Kurup et al., CC BY 4.0

PLOS Pathogens Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model
March 25, 2021 Drishya Kurup, Delphine C. Malherbe, Christoph Wirblich, Rachael Lambert, Adam J. Ronk, Leila Zabihi Diba, Alexander Bukreyev, Matthias J. Schnell

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although…
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Fig 1. Daily new cases of COVID-19 in New Zealand from 26 February to 31 May 2020, split into cases with a recent history of international travel (blue) and those without (orange). by James et al., CC BY 4.0

PLOS ONE Model-free estimation of COVID-19 transmission dynamics from a complete outbreak
March 24, 2021 Alex James, Michael J. Plank, Shaun Hendy, Rachelle N. Binny, Audrey Lustig, Nic Steyn

New Zealand had 1499 cases of COVID-19 before eliminating transmission of the virus. Extensive contract tracing during the outbreak has…
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Fig 2. by Neelon et al., CC BY 4.0

PLOS ONE Spatial and temporal trends in social vulnerability and COVID-19 incidence and death rates in the United States
March 24, 2021 Brian Neelon, Fedelis Mutiso, Noel T. Mueller, John L. Pearce, Sara E. Benjamin-Neelon

Background: Socially vulnerable communities may be at higher risk for COVID-19 outbreaks in the US. However, no prior studies examined…
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Fig 4. Linear trajectories of IL-6. by Manenti et al., CC BY 4.0

PLOS ONE Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study
March 24, 2021 Lucio Manenti, Umberto Maggiore, Enrico Fiaccadori, Tiziana Meschi, Anna Degli Antoni, Antonio Nouvenne, Andrea Ticinesi, Nicoletta Cerundolo, Beatrice Prati, Marco Delsante, Ilaria Gandoflini, Lorenzo Donghi, Micaela Gentile, Maria Teresa Farina, Vincenzo Oliva, Cristina Zambrano, Giuseppe Regolisti, Alessandra Palmisano, Caterina Caminiti, Enrico Cocchi, Carlo Ferrari, Leonardo V. Riella, Paolo Cravedi, Licia Peruzzi

Objectives: Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed. We hypothesized that colchicine, by…
PLOS ONE Symptoms and symptom clusters associated with SARS-CoV-2 infection in community-based populations: Results from a statewide epidemiological study
March 24, 2021 Brian E. Dixon, Kara K. Wools-Kaloustian, William F. Fadel, Thomas J. Duszynski, Constantin Yiannoutsos, Paul K. Halverson, Nir Menachemi

Background: Prior studies examining symptoms of COVID-19 are primarily descriptive and measured among hospitalized individuals.…
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Fig 3. Box plot (left) and ROC curves for Energy (right). by Aragón-Benedí et al., CC BY 4.0

PLOS ONE Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study
March 24, 2021 Cristian Aragón-Benedí, Pablo Oliver-Forniés, Felice Galluccio, Ece Yamak Altinpulluk, Tolga Ergonenc, Abdallah El Sayed Allam, Carlos Salazar, Mario Fajardo-Pérez

Introduction: The analysis of heart rate variability (HRV) has proven to be an important tool for the management of autonomous nerve system…
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Fig 1. WA State DOH COVID-19 confirmed cases by age: 3/1/2020-4/19/2020. by Malmgren et al., CC BY 4.0

PLOS ONE Continued proportional age shift of confirmed positive COVID-19 incidence over time to children and young adults: Washington State March—August 2020
March 24, 2021 Judith Malmgren, Boya Guo, Henry G. Kaplan

Background: As the coronavirus (COVID-19) epidemic passed initial infection peak in Washington State, phased re-opening lifted stay-at-home…
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Fig 1. ROC curve of multivariable logistic regression model. by Betti et al., CC BY 4.0

PLOS ONE Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study
March 24, 2021 Marta Betti, Marinella Bertolotti, Daniela Ferrante, Annalisa Roveta, Carolina Pelazza, Fabio Giacchero, Serena Penpa, Costanza Massarino, Tatiana Bolgeo, Antonella Cassinari, Marco Mussa, Guido Chichino, Antonio Maconi

Background: Individual differences in susceptibility to SARS-CoV-2 infection, symptomatology and clinical manifestation of COVID-19 have…
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Fig 1. BMI is higher in positive versus negative individuals and is associated with severe respiratory symptoms. by Frasca et al., CC BY 4.0

PLOS ONE Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients
March 24, 2021 Daniela Frasca, Lisa Reidy, Carolyn Cray, Alain Diaz, Maria Romero, Kristin Kahl, Bonnie B. Blomberg

SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant…
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Fig 2. Forest plot that shows the weighted pooled proportion of asymptomatic SARS-CoV-2 infection using available studies, 2020. by Alene et al., CC BY 4.0

PLOS ONE Magnitude of asymptomatic COVID-19 cases throughout the course of infection: A systematic review and meta-analysis
March 23, 2021 Muluneh Alene, Leltework Yismaw, Moges Agazhe Assemie, Daniel Bekele Ketema, Belayneh Mengist, Bekalu Kassie, Tilahun Yemanu Birhan

Background: Asymptomatic SARS-CoV-2 infections are responsible for potentially significant transmission of COVID-19. Worldwide, a number of…
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Fig 4. Age and comorbidity—adjusted distribution of fatality among reported hospitalized series with >100 patients and Alicante cohort, stratified according to the management approach. by Andrés et al., CC BY 4.0

PLOS ONE Fatality and risk features for prognosis in COVID-19 according to the care approach – a retrospective cohort study
March 23, 2021 Mariano Andrés, Jose-Manuel Leon-Ramirez, Oscar Moreno-Perez, José Sánchez-Payá, Ignacio Gayá, Violeta Esteban, Isabel Ribes, Diego Torrus-Tendero, Pilar González-de-la-Aleja, Pere Llorens, Vicente Boix, Joan Gil, Esperanza Merino, on behalf of COVID19-ALC research group

Introduction: This study analyzed the impact of a categorized approach, based on patients’ prognosis, on major outcomes and explanators in…
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Fig 1. by Zou et al., CC BY 4.0

PLOS ONE The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT
March 23, 2021 Jia-Ni Zou, Liu Sun, Bin-Ru Wang, You Zou, Shan Xu, Yong-Jun Ding, Li-Jun Shen, Wen-Cai Huang, Xiao-Jing Jiang, Shi-Ming Chen

The characteristics and evolution of pulmonary fibrosis in patients with coronavirus disease 2019 (COVID-19) have not been adequately…
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Fig 1. Relative levels of absorbance from day 0 to day 28. by Bläckberg et al.g, CC BY 4.0

PLOS ONE Antibody kinetics and clinical course of COVID-19 a prospective observational study
March 22, 2021 Anna Bläckberg, Nils Fernström, Emma Sarbrant, Magnus Rasmussen, Torgny Sunnerhagen

Background: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19.…
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Fig 1. Epidemiological curve of the first COVID-19 wave in Basel-City and region, Switzerland. by Stange et al., CC BY 4.0

PLOS Pathogens SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event
March 19, 2021 Madlen Stange, Alfredo Mari, Tim Roloff, Helena MB Seth-Smith, Michael Schweitzer, Myrta Brunner, Karoline Leuzinger, Kirstine K. Søgaard, Alexander Gensch, Sarah Tschudin-Sutter, Simon Fuchs, Julia Bielicki, Hans Pargger, Martin Siegemund, Christian H. Nickel, Roland Bingisser, Michael Osthoff, Stefano Bassetti, Rita Schneider-Sliwa, Manuel Battegay, Hans H. Hirsch, Adrian Egli

The first case of SARS-CoV-2 in Basel, Switzerland was detected on February 26th 2020. We present a phylogenetic study to explore viral…
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Fig 3. Contour plots for R(∞) (top), Imax (middle) and the mean time of infection (bottom) as a function of parameters for the well-mixed population. by Di Lauro et al., CC BY 4.0

PLOS Computational Biology Optimal timing of one-shot interventions for epidemic control
March 18, 2021 Francesco Di Lauro, István Z. Kiss, Joel C. Miller

The interventions and outcomes in the ongoing COVID-19 pandemic are highly varied. The disease and the interventions both impose costs and…
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Fig 1. Comparison of dynamic trajectories of six laboratory parameters in COVID-19 patients between two age groups. by Hu et al., CC BY 4.0

PLOS ONE The effect of age on the clinical and immune characteristics of critically ill patients with COVID-19: A preliminary report
March 18, 2021 Chunling Hu, Junlu Li, Xia Xing, Jing Gao, Shilong Zhao, Lihua Xing

Background: In December 2019, a new disease named coronavirus disease 2019 (COVID-19) was occurred. Patients who are critically ill with…
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Fig 2. Mobility statistics in Tokyo at 15:00: a. (March 13, 2020), b. (April 23, 2020). by Kajitani and Hatayama, CC BY 4.0

PLOS ONE Explaining the effective reproduction number of COVID-19 through mobility and enterprise statistics: Evidence from the first wave in Japan
March 18, 2021 Yoshio Kajitani, Michinori Hatayama

This study uses mobility statistics combined with business census data for the eight Japanese prefectures with the highest coronavirus…
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Fig 1. Time curves of platelet count, six-point ordinal scale score and oxygenation index. by Zhu et al., CC BY 4.0

PLOS ONE Association between thrombocytopenia and 180-day prognosis of COVID-19 patients in intensive care units: A two-center observational study
March 18, 2021 Yuan Zhu, Jing Zhang, Yiming Li, Fang Liu, Qing Zhou, Zhiyong Peng

Background: Thrombocytopenia has been proved to be associated with hospital mortality in patients with severe acute respiratory syndrome…
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Fig 2. Duration of symptoms prior to symptom duration prior to a positive SARS-CoV-2 test among Heathcare Workers (HCW), outpatients, and inpatients, ^a p value 0.04. by McEllistrem et al., CC BY 4.0

PLOS ONE SARS-CoV-2 is associated with high viral loads in asymptomatic and recently symptomatic healthcare workers
March 18, 2021 M. Catherine McEllistrem, Cornelius J. Clancy, Deanna J. Buehrle, Nina Singh, Aaron Lucas, Valerie Sirianni, Brooke K. Decker

Background: Healthcare workers (HCW) are at increased risk of SARS-CoV-2 infection from both patients and other HCW with coronavirus…
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Fig 2. Outcome (A) and mortality density (B) distribution by age disaggregated data and gender of the study population (n = 162,045). by de Souza et al., CC BY 4.0

PLOS ONE On the analysis of mortality risk factors for hospitalized COVID-19 patients: A data-driven study using the major Brazilian database
March 18, 2021 Fernanda Sumika Hojo de Souza, Natália Satchiko Hojo-Souza, Ben Dêivide de Oliveira Batista, Cristiano Maciel da Silva, Daniel Ludovico Guidoni

Background: Brazil became the epicenter of the COVID-19 epidemic in a brief period of a few months after the first officially registered…
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Fig 1. Repeated measurements of six different laboratory parameter from onset of symptoms until discharge between moderately ill and severely ill COVID-19 patients. by Pouw et al., CC BY 4.0

PLOS ONE Clinical characteristics and outcomes of 952 hospitalized COVID-19 patients in The Netherlands: A retrospective cohort study
March 18, 2021 Niels Pouw, Josephine van de Maat, Karin Veerman, Jaap ten Oever, Nico Janssen, Evertine Abbink, Monique Reijers, Quirijn de Mast, Wouter Hoefsloot, Reinout van Crevel, Kitty Slieker, Marjan van Apeldoorn, Marc Blaauw, Anton Dofferhoff, Jacobien Hoogerwerf

Objective: To describe clinical characteristics, disease course and outcomes in a large and well-documented cohort of hospitalized COVID-19…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE The association of COVID-19 occurrence and severity with the use of angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers in patients with hypertension
March 18, 2021 Mingfei Li, Ying Wang, Ndindam Ndiwane, Michelle B. Orner, Natalia Palacios, Brant Mittler, Dan Berlowitz, Lewis E. Kazis, Weiming Xia

Background: A number of studies have reported the association between the use of angiotensin-converting enzyme inhibitor (ACEI) and…
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Fig 1. Nasopharyngeal and tracheal SARS-CoV-2 viral loads in infected cynomolgus macaques treated by a placebo or hydroxychloroquine ± azithromycin. by Gonçalves et al., CC BY 4.0

PLOS Computational Biology SARS-CoV-2 viral dynamics in non-human primates
March 17, 2021 Antonio Gonçalves, Pauline Maisonnasse, Flora Donati, Mélanie Albert, Sylvie Behillil, Vanessa Contreras, Thibaut Naninck, Romain Marlin, Caroline Solas, Andres Pizzorno, Julien Lemaitre, Nidhal Kahlaoui, Olivier Terrier, Raphael Ho Tsong Fang, Vincent Enouf, Nathalie Dereuddre-Bosquet, Angela Brisebarre, Franck Touret, Catherine Chapon, Bruno Hoen, Bruno Lina, Manuel Rosa Calatrava, Xavier de Lamballerie, France Mentré, Roger Le Grand, Sylvie van der Werf, Jérémie Guedj

Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the…
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Fig 1. Standardized diagnostic algorithm for patients with suspected or confirmed COVID-19 associated ARDS. by Lahmer et al., CC BY 4.0

PLOS ONE Invasive pulmonary aspergillosis in critically ill patients with severe COVID-19 pneumonia: Results from the prospective AspCOVID-19 study
March 17, 2021 Tobias Lahmer, Silja Kriescher, Alexander Herner, Kathrin Rothe, Christoph D. Spinner, Jochen Schneider, Ulrich Mayer, Michael Neuenhahn, Dieter Hoffmann, Fabian Geisler, Markus Heim, Gerhard Schneider, Roland M. Schmid, Wolfgang Huber, Sebastian Rasch

Background: Superinfections, including invasive pulmonary aspergillosis (IPA), are well-known complications of critically ill patients with…
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Fig 1. Cumulative incidence of COVID-19 over a selected period in 15 countries in Western Europe (log scale). by Locatelli et al., CC BY 4.0

PLOS ONE Estimating the basic reproduction number for COVID-19 in Western Europe
March 17, 2021 Isabella Locatelli, Bastien Trächsel, Valentin Rousson

Objective: To estimate the basic reproduction number (R0) for COVID-19 in Western Europe. Methods: Data (official statistics) on the…
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Untitled by Zaferani Arani et al., CC BY 4.0

PLOS ONE Understanding the clinical and demographic characteristics of second coronavirus spike in 192 patients in Tehran, Iran: A retrospective study
March 19, 2021 Hamid Zaferani Arani, Giti Dehghan Manshadi, Hesam Adin Atashi, Aida Rezaei Nejad, Seyyed Mojtaba Ghorani, Soheila Abolghasemi, Maryam Bahrani, Homayoon Khaledian, Pantea Bozorg Savodji, Mohammad Hoseinian, Atefe Kazemzade Bejandi, Shahla Abolghasemi

During the last months of the coronavirus pandemic, with all those public restrictions and health interventions, the transmission of…
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Fig 1. Frequency of MOCHA abnormalities in patients with thrombotic endpoints, intubation and ICU admission. by Alabyad et al., CC BY 4.0

PLOS ONE Validation of an admission coagulation panel for risk stratification of COVID-19 patients
March 19, 2021 Darwish Alabyad, Srikant Rangaraju, Michael Liu, Rajeel Imran, Christine L. Kempton, Milad Sharifpour, Sara C. Auld, Manila Gaddh, Roman Sniecinski, Cheryl L. Maier, Jeannette Guarner, Alexander Duncan, Fadi Nahab

Background: There is limited data on the markers of coagulation and hemostatic activation (MOCHA) profile in Coronavirus disease 2019…
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Fig 3. Age distribution by treatment group. by Stewart et al., CC BY 4.0

PLOS ONE COVID-19 Evidence Accelerator: A parallel analysis to describe the use of Hydroxychloroquine with or without Azithromycin among hospitalized COVID-19 patients
March 17, 2021 Mark Stewart, Carla Rodriguez-Watson, Adem Albayrak, Julius Asubonteng, Andrew Belli, Thomas Brown, Kelly Cho, Ritankar Das, Elizabeth Eldridge, Nicolle Gatto, Alice Gelman, Hanna Gerlovin, Stuart L. Goldberg, Eric Hansen, Jonathan Hirsch, Yuk-Lam Ho, Andrew Ip, Monika Izano, Jason Jones, Amy C. Justice, Reyna Klesh, Seth Kuranz, Carson Lam, Qingqing Mao, Samson Mataraso, Robertino Mera, Daniel C. Posner, Jeremy A. Rassen, Anna Siefkas, Andrew Schrag, Georgia Tourassi, Andrew Weckstein, Frank Wolf, Amar Bhat, Susan Winckler, Ellen V. Sigal, Jeff Allen

Background: The COVID-19 pandemic remains a significant global threat. However, despite urgent need, there remains uncertainty surrounding…
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Fig 5. Predictions for air freight in the U.S. by Meng et al., CC BY 4.0

PLOS ONE Impact of different control policies for COVID-19 outbreak on the air transportation industry: A comparison between China, the U.S. and Singapore
March 16, 2021 Fanyu Meng, Wenwu Gong, Jun Liang, Xian Li, Yiping Zeng, Lili Yang

Many countries have been implementing various control measures with different strictness levels to prevent the coronavirus disease 2019…
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Fig 2. Distribution of 264 patients with SARS-CoV-2 infection according to age groups and mortality rates. by De Vito et al., CC BY 4.0

PLOS ONE Predictors of infection, symptoms development, and mortality in people with SARS-CoV-2 living in retirement nursing homes
March 16, 2021 Andrea De Vito, Vito Fiore, Elija Princic, Nicholas Geremia, Catello Mario Panu Napodano, Alberto Augusto Muredda, Ivana Maida, Giordano Madeddu, Sergio Babudieri

Introduction: Since the start of the pandemic, millions of people have been infected, with thousands of deaths. Many foci worldwide have…
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Fig 1. Flowchart of inclusion and exclusion criteria. by Kheir et al., CC BY 4.0

PLOS ONE Higher albumin levels on admission predict better prognosis in patients with confirmed COVID-19
March 16, 2021 Matthew Kheir, Farah Saleem, Christy Wang, Amardeep Mann, Jimmy Chua

Background: Research surrounding COVID-19 (coronavirus disease 2019) is rapidly increasing, including the study of biomarkers for…
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Untitled by Schuler et al., CC BY 4.0

PLOS ONE Accurate point-of-care serology tests for COVID-19
March 16, 2021 Charles F. Schuler IV, Carmen Gherasim, Kelly O’Shea, David M. Manthei, Jesse Chen, Don Giacherio, Jonathan P. Troost, James L. Baldwin, James R. Baker Jr

Background: As COVID-19 vaccines become available, screening individuals for prior COVID-19 infection and vaccine response in point-of-care…
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Fig 1. Types and number of comorbidities among 492 COVID-19 patients with comorbidities admitted in Lagos isolation centers from January 27 to July 6, 2020. by Osibogun et al., CC BY 4.0

PLOS ONE Outcomes of COVID-19 patients with comorbidities in southwest Nigeria
March 15, 2021 Akin Osibogun, Mobolanle Balogun, Akin Abayomi, Jide Idris, Yetunde Kuyinu, Oluwakemi Odukoya, Ololade Wright, Remi Adeseun, Bamidele Mutiu, Babatunde Saka, Nike Osa, Dayo Lajide, Ismael Abdus-Salam, Bodunrin Osikomaiya, Oluwatosin Onasanya, Bisola Adebayo, Yewande Oshodi, Sunday Adesola, Olu Adejumo, Olufemi Erinoso, Hussein Abdur-Razzaq, Abimbola Bowale, Kingsley Akinroye

Background: Data on the comorbidities that result in negative outcomes for people with COVID-19 are currently scarce for African…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Laboratory biomarkers of COVID-19 disease severity and outcome: Findings from a developing country
March 15, 2021 Tigist W. Leulseged, Ishmael S. Hassen, Birhanu T. Ayele, Yakob G. Tsegay, Daniel S. Abebe, Mesay G. Edo, Endalkachew H. Maru, Wuletaw C. Zewde, Lydia K. Naylor, Dejene F. Semane, Menayit T. Dresse, Bereket B. Tezera

Aim: To identify laboratory biomarkers that predict disease severity and outcome among COVID-19 patients admitted to the Millennium…
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Untitled by MacLean et al., CC BY 4.0

PLOS Biology Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen
March 12, 2021 Oscar A. MacLean, Spyros Lytras, Steven Weaver, Joshua B. Singer, Maciej F. Boni, Philippe Lemey, Sergei L. Kosakovsky Pond, David L. Robertson

Virus host shifts are generally associated with novel adaptations to exploit the cells of the new host species optimally. Surprisingly,…
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Fig 1. Level of knowledge on the transmission, prevention and practice of precautionary measure of COVID-19. by Defar et al., CC BY 4.0

PLOS ONE Knowledge, practice and associated factors towards the prevention of COVID-19 among high-risk groups: A cross-sectional study in Addis Ababa, Ethiopia
March 11, 2021 Atkure Defar, Gebeyaw Molla, Saro Abdella, Masresha Tessema, Muhammed Ahmed, Ashenif Tadele, Fikresilassie Getachew, Bezawit Hailegiorgis, Eyasu Tigabu, Sabit Ababor, Ketema Bizuwork, Asefa Deressa, Geremew Tasaw, Adisu Kebede, Daniel Melese, Andargachew Gashu, Kirubel Eshetu, Adamu Tayachew, Mesfin Wossen, Abduilhafiz Hassen, Shambel Habebe, Zewdu Assefa, Aschalew Abayneh, Ebba Abate, Getachew Tollera

Background: Coronavirus disease (COVID-19) is a highly transmittable virus that continues to disrupt livelihoods, particularly those of…
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Table 4. Matrix of binary Jaccard similarity coefficients between clinical signs and the COVID-19 status. by Saegerman et al., CC BY 4.0

PLOS ONE Clinical decision support tool for diagnosis of COVID-19 in hospitals
March 11, 2021 Claude Saegerman, Allison Gilbert, Anne-Françoise Donneau, Marjorie Gangolf, Anh Nguvet Diep, Cécile Meex, Sébastien Bontems, Marie-Pierre Hayette, Vincent D’Orio, Alexandre Ghuysen

Background: The coronavirus infectious disease 19 (COVID-19) pandemic has resulted in significant morbidities, severe acute respiratory…
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Fig 5. Trial sequential analysis for remdesivir versus control (standard care or placebo) on all-cause mortality. by Juul et al., CC BY 4.0

PLOS ONE Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
March 11, 2021 Sophie Juul, Emil Eik Nielsen, Joshua Feinberg, Faiza Siddiqui, Caroline Kamp Jørgensen, Emily Barot, Johan Holgersson, Niklas Nielsen, Peter Bentzer, Areti Angeliki Veroniki, Lehana Thabane, Fanlong Bu, Sarah Klingenberg, Christian Gluud, Janus Christian Jakobsen

Background: COVID-19 is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world.…
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Fig 2. Transmission of COVID-19 infection among close contact households. by Gomaa et al., CC BY 4.0

PLOS Pathogens Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort
March 11, 2021 Mokhtar R. Gomaa, Amira S. El Rifay, Mahmoud Shehata, Ahmed Kandeil, Mina Nabil Kamel, Mohamed A. Marouf, Mohamed GabAllah, Ahmed El Taweel, Ahmed E. Kayed, Omnia Kutkat, Yassmin Moatasim, Sara H. Mahmoud, Noura M. Abo Shama, Mohamed El Sayes, Ahmed Mostafa, Rabeh El-Shesheny, Pamela P. McKenzie, Richard J. Webby, Ghazi Kayali, Mohamed A. Ali

SARS-CoV-2 virus is transmitted in closed settings to people in contact with COVID-19 patients such as healthcare workers and household…
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Fig 1. ND COVID-19 Dashboard Fall 2020 (https://here.nd.edu/our-approach/dashboard/fall-2020-data/) with data for all (diagnostic and surveillance) on-campus COVID-19 tests posted as of December 16, 2020. by Kasturi Haldar, CC BY 4.0

PLOS Pathogens The pivot: Fighting Irish fighting COVID-19
March 10, 2021 Kasturi Haldar

…
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Fig 2. Characteristics of chest computed tomography scan in COVID-19 patients. by Liu et al., CC BY 4.0

PLOS Neglected Tropical Diseases Epidemiological and clinical features in patients with coronavirus disease 2019 outside of Wuhan, China: Special focus in asymptomatic patients
March 10, 2021 Ping Liu, Ruichao Niu, Jie Chen, Yuling Tang, Wenfang Tang, Linyan Xu, Juntao Feng

Objectives: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan City and rapidly spread across the world. The clinical…
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Fig 1. Flowchart of the study. by Gülbay et al., CC BY 4.0

PLOS ONE A CT radiomics analysis of COVID-19-related ground-glass opacities and consolidation: Is it valuable in a differential diagnosis with other atypical pneumonias?
March 10, 2021 Mutlu Gülbay, Bahadır Orkun Özbay, Bökebatur Ahmet Raşit Mendi, Aliye Baştuğ, Hürrem Bodur

Purpose: To evaluate the discrimination of parenchymal lesions between COVID-19 and other atypical pneumonia (AP) by using only radiomics…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Prevalence of COVID-19 in adolescents and youth compared with older adults in states experiencing surges
March 10, 2021 Barbara Rumain, Moshe Schneiderman, Allan Geliebter

Purpose: There has been considerable controversy regarding susceptibility of adolescents (10–19 years) and youth (15–24 years) to COVID-19.…
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Fig 1. The CORC score by number of points. by Kline et al., CC BY 4.0

PLOS ONE Clinical prediction rule for SARS-CoV-2 infection from 116 U.S. emergency departments 2-22-2021
March 10, 2021 Jeffrey A. Kline, Carlos A. Camargo Jr., D. Mark Courtney, Christopher Kabrhel, Kristen E. Nordenholz, Thomas Aufderheide, Joshua J. Baugh, David G. Beiser, Christopher L. Bennett, Joseph Bledsoe, Edward Castillo, Makini Chisolm-Straker, Elizabeth M. Goldberg, Hans House, Stacey House, Timothy Jang, Stephen C. Lim, Troy E. Madsen, Danielle M. McCarthy, Andrew Meltzer, Stephen Moore, Craig Newgard, Justine Pagenhardt, Katherine L. Pettit, Michael S. Pulia, Michael A. Puskarich, Lauren T. Southerland, Scott Sparks, Danielle Turner-Lawrence, Marie Vrablik, Alfred Wang, Anthony J. Weekes, Lauren Westafer, John Wilburn

Objectives: Accurate and reliable criteria to rapidly estimate the probability of infection with the novel coronavirus-2 that causes the…
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Fig 1. We consider that an individual goes through different phases of infection/disease, which is represented by a SEIR-like state machine. by Libin et al., CC BY 4.0

PLOS Computational Biology Assessing the feasibility and effectiveness of household-pooled universal testing to control COVID-19 epidemics
March 9, 2021 Pieter J. K. Libin, Lander Willem, Timothy Verstraeten, Andrea Torneri, Joris Vanderlocht, Niel Hens

Outbreaks of SARS-CoV-2 are threatening the health care systems of several countries around the world. The initial control of SARS-CoV-2…
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Fig 1. Schematic presentation of the sampling procedure for the study conducted among health professionals in public health facilities of Gamo zone, southern Ethiopia, 2020. by Mersha et al., CC BY 4.0

PLOS ONE Health professionals practice and associated factors towards precautionary measures for COVID-19 pandemic in public health facilities of Gamo zone, southern Ethiopia: A cross-sectional study
March 9, 2021 Abera Mersha, Shitaye Shibiru, Meseret Girma, Gistane Ayele, Agegnehu Bante, Mekidim Kassa, Sintayehu Abebe, Misgun Shewangizaw

Introduction: Coronavirus disease-2019 (COVID-19) is a highly contagious acute respiratory disease, which caused by a novel coronavirus.…
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Fig 3. Total compliance during healthcare interactions and when performing AGPs. by Ashinyo et al., CC BY 4.0

PLOS ONE Infection prevention and control compliance among exposed healthcare workers in COVID-19 treatment centers in Ghana: A descriptive cross-sectional study
March 9, 2021 Mary Eyram Ashinyo, Stephen Dajaan Dubik, Vida Duti, Kingsley Ebenezer Amegah, Anthony Ashinyo, Brian Adu Asare, Angela Ama Ackon, Samuel Kaba Akoriyea, Patrick Kuma-Aboagye

Compliance with infection prevention and control (IPC) protocols is critical in minimizing the risk of coronavirus disease (COVID-19)…
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Fig 2. Block diagram of the COVID-19 SEIR model with shield immunity control. by Xu et al., CC BY 4.0

PLOS ONE Control strategies for COVID-19 epidemic with vaccination, shield immunity and quarantine: A metric temporal logic approach
March 5, 2021 Zhe Xu, Bo Wu, Ufuk Topcu

Ever since the outbreak of the COVID-19 epidemic, various public health control strategies have been proposed and tested against the…
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Fig 1. by Brault et al., CC BY 4.0

PLOS Computational Biology Group testing as a strategy for COVID-19 epidemiological monitoring and community surveillance
March 4, 2021 Vincent Brault, Bastien Mallein, Jean-François Rupprecht

We propose an analysis and applications of sample pooling to the epidemiologic monitoring of COVID-19. We first introduce a model of the…
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Fig 2. by Richard et al., CC BY 4.0

PLOS Computational Biology Age-structured non-pharmaceutical interventions for optimal control of COVID-19 epidemic
March 4, 2021 Quentin Richard, Samuel Alizon, Marc Choisy, Mircea T. Sofonea, Ramsès Djidjou-Demasse

In an epidemic, individuals can widely differ in the way they spread the infection depending on their age or on the number of days they…
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Novel Coronavirus SARS-CoV-2 Spike Protein by NIH, CC-0 Public Domain

PLOS Medicine Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis
March 4, 2021 Aaron Leong, Joanne B. Cole, Laura N. Brenner, James B. Meigs, Jose C. Florez, Josep M. Mercader

Background: Epidemiological studies report associations of diverse cardiometabolic conditions including obesity with COVID-19 illness, but…
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Fig 1. Graphical abstract. by Refat et al., CC BY 4.0

PLOS ONE Quercetin/Zinc complex and stem cells: A new drug therapy to ameliorate glycometabolic control and pulmonary dysfunction in diabetes mellitus: Structural characterization and genetic studies
March 4, 2021 Moamen S. Refat, Reham Z. Hamza, Abdel Majid A. Adam, Hosam A. Saad, Adil A. Gobouri, Fatimah S. Al-Harbi, Fawziah A. Al-Salmi, Tariq Altalhi, Samy M. El-Megharbel

Medicinal uses and applications of metals and their complexes are of increasing clinical and commercial importance. The ligation behavior…
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Fig 3. Relation between force of infection, sensitivity and specificity in the Colombo data. by Alexander et al., CC BY 4.0

PLOS ONE Estimating force of infection from serologic surveys with imperfect tests
March 4, 2021 Neal Alexander, Mabel Carabali, Jacqueline K. Lim

Background: The force of infection, or the rate at which susceptible individuals become infected, is an important public health measure for…
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Fig 1. by Vahid S. Bokharaie, CC BY 4.0

PLOS ONE A study on the effects of containment policies and vaccination on the spread of SARS-CoV-2
March 4, 2021 Vahid S. Bokharaie

This paper presents a method to predict the spread of the SARS-CoV-2 in a population with a known age-structure, and then, to quantify the…
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Fig 1. Immunofluorescence assay (IFA) against SARS-CoV-2 proteins. by Tso et al., CC BY 4.0

PLOS ONE Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma
March 4, 2021 For Yue Tso, Salum J. Lidenge, Lisa K. Poppe, Phoebe B. Peña, Sara R. Privatt, Sydney J. Bennett, John R. Ngowi, Julius Mwaiselage, Michael Belshan, Jacob A. Siedlik, Morgan A. Raine, Juan B. Ochoa, Julia Garcia-Diaz, Bobby Nossaman, Lyndsey Buckner, W. Mark Roberts, Matthew J. Dean, Augusto C. Ochoa, John T. West, Charles Wood

Background: Neutralizing-antibody (nAb) is the major focus of most ongoing COVID-19 vaccine trials. However, nAb response against…
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Fig 1. Schematic of Easy Check COVID-19 IgM/IgG^TM lateral flow assay. by Higgins et al., CC BY 4.0

PLOS ONE Longitudinal SARS-CoV-2 antibody study using the Easy Check COVID-19 IgM/IgG™ lateral flow assay
March 4, 2021 Renee L. Higgins, Stephen A. Rawlings, Jamie Case, Florence Y. Lee, Clarence W. Chan, Bethany Barrick, Zoe C. Burger, Kiang-Teck J. Yeo, Dena Marrinucci

Since the initial identification of the novel coronavirus SARS-CoV-2 in December of 2019, researchers have raced to understand its…
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Fig 3. Cumulative frequency: Number of days between onset of symptoms and follow-up consultation at ambulatory follow-up unit (AFU). by Chevallier Lugon et al., CC BY 4.0

PLOS ONE Novel outpatient management of mild to moderate COVID-19 spares hospital capacity and safeguards patient outcome: The Geneva PneumoCoV-Ambu study
March 4, 2021 Chloé Chevallier Lugon, Mikaela Smit, Julien Salamun, Meriem Abderrahmane, Olivia Braillard, Mayssam Nehme, Frédérique Jacquerioz Bausch, Idris Guessous, Hervé Spechbach

Background: Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes coronavirus disease (COVID-19), is…
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Novel Coronavirus SARS-CoV-2 Spike Protein by NIH, CC-0 Public Domain

PLOS ONE Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis
March 4, 2021 Adam Booth, Angus Bruno Reed, Sonia Ponzo, Arrash Yassaee, Mert Aral, David Plans, Alain Labrique, Diwakar Mohan

Aim: COVID-19 clinical presentation is heterogeneous, ranging from asymptomatic to severe cases. While there are a number of early…
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Fig 2. Time from enrollment to key secondary outcomes. by Balcells et al., CC BY 4.0

PLOS Medicine Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial
March 3, 2021 María Elvira Balcells, Luis Rojas, Nicole Le Corre, Constanza Martínez-Valdebenito, María Elena Ceballos, Marcela Ferrés, Mayling Chang, Cecilia Vizcaya, Sebastián Mondaca, Álvaro Huete, Ricardo Castro, Mauricio Sarmiento, Luis Villarroel, Alejandra Pizarro, Patricio Ross, Jaime Santander, Bárbara Lara, Marcela Ferrada, Sergio Vargas-Salas, Carolina Beltrán-Pavez, Ricardo Soto-Rifo, Fernando Valiente-Echeverría, Christian Caglevic, Mauricio Mahave, Carolina Selman, Raimundo Gazitúa, José Luis Briones, Franz Villarroel-Espindola, Carlos Balmaceda, Manuel A. Espinoza, Jaime Pereira, Bruno Nervi

Background: Convalescent plasma (CP), despite limited evidence on its efficacy, is being widely used as a compassionate therapy for…
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Fig 1. by Hassan et al., CC BY 4.0

PLOS ONE Impact of multiple waves of COVID-19 on healthcare networks in the United States
March 3, 2021 Emad M. Hassan, Hussam N. Mahmoud

The risk of overwhelming hospitals from multiple waves of COVID-19 is yet to be quantified. Here, we investigate the impact of different…
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Fig 1. Kaplan-Meier analysis by transplant. by Linares et al., CC BY 4.0

PLOS ONE A propensity score-matched analysis of mortality in solid organ transplant patients with COVID-19 compared to non-solid organ transplant patients
March 3, 2021 Laura Linares, Frederic Cofan, Fritz Diekmann, Sabina Herrera, María Angeles Marcos, María Angeles Castel, Marta Farrero, Jordi Colmenero, Pablo Ruiz, Gonzalo Crespo, Jaume Llopis, Carolina Garcia-Vidal, Àlex Soriano, Asunción Moreno, Marta Bodro, on behalf of Hospital Clínic COVID-19 research group

In the context of COVID-19 pandemic, we aimed to analyze the epidemiology, clinical characteristics, risk factors for mortality and impact…
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Fig 1. Timeline of COVID19 in three pandemic hospitals. by Alkurt et al., CC BY 4.0

PLOS ONE Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey
March 3, 2021 Gizem Alkurt, Ahmet Murt, Zeki Aydin, Ozge Tatli, Nihat Bugra Agaoglu, Arzu Irvem, Mehtap Aydin, Ridvan Karaali, Mustafa Gunes, Batuhan Yesilyurt, Hasan Turkez, Adil Mardinoglu, Mehmet Doganay, Filiz Basinoglu, Nurhan Seyahi, Gizem Dinler Doganay, Hamdi Levent Doganay

COVID-19 is a global threat with an increasing number of infections. Research on IgG seroprevalence among health care workers (HCWs) is…
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Fig 1. Limit of detection for the monoplex SARS CoV-2 RT-LAMP assay. by Jang et al., CC BY 4.0

PLOS ONE Development of a multiplex Loop-Mediated Isothermal Amplification (LAMP) assay for on-site diagnosis of SARS CoV-2
March 3, 2021 Woong Sik Jang, Da Hye Lim, Jung Yoon, Ahran Kim, Minsup Lim, Jeonghun Nam, Richard Yanagihara, Sook-Won Ryu, Bo Kyeung Jung, Nam-Hee Ryoo, Chae Seung Lim

A newly identified coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has spread rapidly from its…
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Fig 4. Relative demand for COVID-19 related chest imaging of in-patients and relative number of regional COVID-19 cases. by Koehler et al., CC BY 4.0

PLOS ONE Time series analysis of the demand for COVID-19 related chest imaging during the first wave of the SARS-CoV-2 pandemic: An explorative study
March 3, 2021 Daniel Koehler, Ann-Kathrin Ozga, Isabel Molwitz, Philipp May, Hanna Maria Görich, Sarah Keller, Gerhard Adam, Jin Yamamura

Objectives: The aim of this study was to investigate possible patterns of demand for chest imaging during the first wave of the SARS-CoV-2…
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Fig 3. Chronology of smell changes among COVID-positive healthcare workers relative to the day of positive test. by Weiss et al., CC BY 4.0

PLOS ONE Tracking smell loss to identify healthcare workers with SARS-CoV-2 infection
March 3, 2021 Julian J. Weiss, Tuki N. Attuquayefio, Elizabeth B. White, Fangyong Li, Rachel S. Herz, Theresa L. White, Melissa Campbell, Bertie Geng, Rupak Datta, Anne L. Wyllie, Nathan D. Grubaugh, Arnau Casanovas-Massana, M. Catherine Muenker, Adam J. Moore, Ryan Handoko, Akiko Iwasaki, Richard A. Martinello, Albert I. Ko, Dana M. Small, Shelli F. Farhadian, the Yale IMPACT Research Team

Introduction: Healthcare workers (HCW) treating COVID-19 patients are at high risk for infection and may also spread infection through…
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Fig 2. Crystal structure of the SR31-RBD complex. by Yao et al., CC BY 4.0

PLOS Pathogens A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2
March 3, 2021 Hebang Yao, Hongmin Cai, Tingting Li, Bingjie Zhou, Wenming Qin, Dimitri Lavillette, Dianfan Li

A key step to the SARS-CoV-2 infection is the attachment of its Spike receptor-binding domain (S RBD) to the host receptor ACE2.…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers associated with lower risk of COVID-19 in household contacts
March 2, 2021 Katrina Armstrong, Alex Soltoff, Meghan Rieu-Werden, Joshua Metlay, Jennifer Haas

Background: Use of angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) has been hypothesized to affect…
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Fig 4. The mean time to reach a detectable viral load at the infection site. by Czuppon et al., CC BY 4.0

PLOS Computational Biology Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action
March 1, 2021 Peter Czuppon, Florence Débarre, Antonio Gonçalves, Olivier Tenaillon, Alan S. Perelson, Jérémie Guedj, François Blanquart

Repurposed drugs that are safe and immediately available constitute a first line of defense against new viral infections. Despite limited…
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Fig 1. β2-m levels in Covid-19 on admission to the hospital. by Conca et al., CC BY 4.0

PLOS ONE Serum β₂-microglobulin levels in Coronavirus disease 2019 (Covid-19): Another prognosticator of disease severity?
March 1, 2021 Walter Conca, Mayyadah Alabdely, Faisal Albaiz, Michael Warren Foster, Maha Alamri, Morad Alkaff, Futwan Al-Mohanna, Nicolaas Nagelkerke, Reem Saad Almaghrabi

β2-microglobulin (β2-m), a 11.8 kDa protein, pairs non-covalently with the α3 domain of the major histocompatibility class (MHC) I α-chain…
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Fig 1. Practices of clients towards COVID-19 prevention measures in Dessie town public health facilities, Ethiopia, 2020 (n = 81). by Dewau et al., CC BY 4.0

PLOS ONE Knowledge and practice of clients on preventive measures of COVID-19 pandemic among governmental health facilities in South Wollo, Ethiopia: A facility-based cross-sectional study
March 1, 2021 Reta Dewau, Tefera Chane Mekonnen, Sisay Eshete Tadesse, Amare Muche, Getahun Gebre Bogale, Erkihun Tadesse Amsalu

Introduction: Coronavirus-19 is a global health challenge and need an immediate action. Thus, understanding client’s knowledge about…
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Fig 2. Spatial representation of data on outcome and key predictor variables (reprinted from https://tapiquen-sig.jimdofree.com/descargas-gratuitas/mundo/, under a CC BY license, with permission from Carlos Efrain Porto Tapiquen, 2021). by Amadu et al., CC BY 4.0

PLOS ONE Assessing sub-regional-specific strengths of healthcare systems associated with COVID-19 prevalence, deaths and recoveries in Africa
March 1, 2021 Iddrisu Amadu, Bright Opoku Ahinkorah, Abdul-Rahaman Afitiri, Abdul-Aziz Seidu, Edward Kwabena Ameyaw, John Elvis Hagan Jr, Eric Duku, Simon Appah Aram

Introduction: The coronavirus 2019 (COVID-19) has overwhelmed the health systems of several countries, particularly those within the…
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Fig 5. Conceptual figure on how a discrepancy between the test validation and serosurvey data can be detected. by Bouman et al., CC BY 4.0

PLOS Computational Biology Estimating the cumulative incidence of SARS-CoV-2 with imperfect serological tests: Exploiting cutoff-free approaches
February 26, 2021 Judith A. Bouman, Julien Riou, Sebastian Bonhoeffer, Roland R. Regoes

Large-scale serological testing in the population is essential to determine the true extent of the current SARS-CoV-2 pandemic.…
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Fig 2. Cumulative incidence plot for a composite outcome of invasive ventilatory support and mortality. by Efros et al., CC BY 4.0

PLOS ONE Myocardial injury in hospitalized patients with COVID-19 infection—Risk factors and outcomes
February 26, 2021 Orly Efros, Noam Barda, Eshcar Meisel, Avshalom Leibowitz, Alexander Fardman, Galia Rahav, Robert Klempfner, Ehud Grossman

Myocardial injury in hospitalized patients is associated with poor prognosis. This study aimed to evaluate risk factors for myocardial…
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Fig 1. by Mulu et al., CC BY 4.0

PLOS ONE Evaluation of sample pooling for screening of SARS CoV-2
February 26, 2021 Andargachew Mulu, Dawit Hailu Alemayehu, Fekadu Alemu, Dessalegn Abeje Tefera, Sinknesh Wolde, Gebeyehu Aseffa, Tamrayehu Seyoum, Meseret Habtamu, Alemseged Abdissa, Abebe Genetu Bayih, Getachew Tesfaye Beyene

Background: The coronavirus disease 2019 (COVID-19) pandemic has revealed the global public health importance of robust diagnostic testing.…
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Fig 2. Plasmablast-derived IgG monoclonal antibodies from three COVID-19 patients. by Huang et al., CC BY 4.0

PLOS Pathogens Breadth and function of antibody response to acute SARS-CoV-2 infection in humans
February 26, 2021 Kuan-Ying A. Huang, Tiong Kit Tan, Ting-Hua Chen, Chung-Guei Huang, Ruth Harvey, Saira Hussain, Cheng-Pin Chen, Adam Harding, Javier Gilbert-Jaramillo, Xu Liu, Michael Knight, Lisa Schimanski, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Jia-Tsrong Jan, Che Ma, William James, Rodney S. Daniels, John W. McCauley, Pramila Rijal, Alain R. Townsend

Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) have been analysed in three COVID-19…
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Fig 1. Experimental timeline. by Braun et al., CC BY 4.0

PLOS Pathogens Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck
February 26, 2021 Katarina M. Braun, Gage K. Moreno, Peter J. Halfmann, Emma B. Hodcroft, David A. Baker, Emma C. Boehm, Andrea M. Weiler, Amelia K. Haj, Masato Hatta, Shiho Chiba, Tadashi Maemura, Yoshihiro Kawaoka, Katia Koelle, David H. O’Connor, Thomas C. Friedrich

The evolutionary mechanisms by which SARS-CoV-2 viruses adapt to mammalian hosts and, potentially, undergo antigenic evolution depend on…
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Fig 6. Daily number of retweets vs. regional daily infected time courses and wavelet analysis. by Rivieccio et al., CC BY 4.0

PLOS ONE CoViD-19, learning from the past: A wavelet and cross-correlation analysis of the epidemic dynamics looking to emergency calls and Twitter trends in Italian Lombardy region
February 25, 2021 Bruno Alessandro Rivieccio, Alessandra Micheletti, Manuel Maffeo, Matteo Zignani, Alessandro Comunian, Federica Nicolussi, Silvia Salini, Giancarlo Manzi, Francesco Auxilia, Mauro Giudici, Giovanni Naldi, Sabrina Gaito, Silvana Castaldi, Elia Biganzoli

The first case of Coronavirus Disease 2019 in Italy was detected on February the 20th in Lombardy region. Since that date, Lombardy has…
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Fig 1. Results of Ewing’s autonomic battery. by Townsend et al., CC BY 4.0

PLOS ONE Fatigue following COVID-19 infection is not associated with autonomic dysfunction
February 25, 2021 Liam Townsend, David Moloney, Ciaran Finucane, Kevin McCarthy, Colm Bergin, Ciaran Bannan, Rose-Anne Kenny

Background: The long-term clinical and physiological consequences of COVID-19 infection remain unclear. While fatigue has emerged as a…
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Fig 2. The association between participants’ occupations, type of dwelling and SARS-CoV-2 seroprevalence. by Shaw et al., CC BY 4.0

PLOS ONE Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa
February 25, 2021 Jane Alexandra Shaw, Maynard Meiring, Tracy Cummins, Novel N. Chegou, Conita Claassen, Nelita Du Plessis, Marika Flinn, Andriette Hiemstra, Léanie Kleynhans, Vinzeigh Leukes, Andre G. Loxton, Candice MacDonald, Nosipho Mtala, Helmuth Reuter, Donald Simon, Kim Stanley, Gerard Tromp, Wolfgang Preiser, Stephanus T. Malherbe, Gerhard Walzl

Background: Inequality is rife throughout South Africa. The first wave of COVID-19 may have affected people in lower socioeconomic groups…
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Fig 1. The 102 Chinese cities selected in the study. by Chong et al., CC BY 4.0

PLOS Neglected Tropical Diseases Limited role for meteorological factors on the variability in COVID-19 incidence: A retrospective study of 102 Chinese cities
February 24, 2021 Ka Chun Chong, Jinjun Ran, Steven Yuk Fai Lau, William Bernard Goggins, Shi Zhao, Pin Wang, Linwei Tian, Maggie Haitian Wang, Kirran N. Mohammad, Lai Wei, Xi Xiong, Hengyan Liu, Paul Kay Sheung Chan, Huwen Wang, Yawen Wang, Jingxuan Wang

While many studies have focused on identifying the association between meteorological factors and the activity of COVID-19, we argue that…
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Fig 1. The four stages of the viral infection of a cell in the model. by Vafadar et al., CC BY 4.0

PLOS ONE Competitive exclusion during co-infection as a strategy to prevent the spread of a virus: A computational perspective
February 24, 2021 Safar Vafadar, Maryam Shahdoust, Ata Kalirad, Pooya Zakeri, Mehdi Sadeghi

Inspired by the competition exclusion principle, this work aims at providing a computational framework to explore the theoretical…
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Fig 1. by Pagani et al., CC BY 4.0

PLOS ONE Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation: Mass seroepidemiological screening in Castiglione d’Adda, Italy
February 24, 2021 Gabriele Pagani, Andrea Giacomelli, Federico Conti, Dario Bernacchia, Rossana Rondanin, Andrea Prina, Vittore Scolari, Arianna Rizzo, Martina Beltrami, Camilla Caimi, Cecilia Eugenia Gandolfi, Silvana Castaldi, Bruno Alessandro Rivieccio, Giacomo Buonanno, Giuseppe Marano, Cosimo Ottomano, Patrizia Boracchi, Elia Biganzoli, Massimo Galli

Castiglione D’Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome…
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Fig 1. Displaceable probe LAMP to detect SARS-CoV-2. by Yaren et al., CC BY 4.0

PLOS ONE Ultra-rapid detection of SARS-CoV-2 in public workspace environments
February 24, 2021 Ozlem Yaren, Jacquelyn McCarter, Nikhil Phadke, Kevin M. Bradley, Benjamin Overton, Zunyi Yang, Shatakshi Ranade, Kunal Patil, Rishikesh Bangale, Steven A. Benner

Managing the pandemic caused by SARS-CoV-2 requires new capabilities in testing, including the possibility of identifying, in minutes,…
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Fig 2. Imbalance data handling process. by Osman et al., CC BY 4.0

PLOS ONE SOM-LWL method for identification of COVID-19 on chest X-rays
February 24, 2021 Ahmed Hamza Osman, Hani Moetque Aljahdali, Sultan Menwer Altarrazi, Ali Ahmed

The outbreak of coronavirus disease 2019 (COVID-19) has had an immense impact on world health and daily life in many countries. Sturdy…
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Fig 1. Cumulative incidence plot displaying probability of discharge, AKI, and death for individuals in the top and bottom 50^th percentile of viral load. by Paranjpe et al., CC BY 4.0

PLOS ONE Association of SARS-CoV-2 viral load at admission with in-hospital acute kidney injury: A retrospective cohort study
February 24, 2021 Ishan Paranjpe, Kumardeep Chaudhary, Kipp W. Johnson, Suraj K. Jaladanki, Shan Zhao, Jessica K. De Freitas, Elisabet Pujdas, Fayzan Chaudhry, Erwin P. Bottinger, Matthew A. Levin, Zahi A. Fayad, Alexander W. Charney, Jane Houldsworth, Carlos Cordon-Cardo, Benjamin S. Glicksberg, Girish N. Nadkarni

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated Coronavirus Disease 2019 (COVID-19) is a public…
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Fig 2. Expression of ACE2 is higher and TMPRSS2 is lower in preterm lungs compared to full-term and adult lungs. by Soni et al., CC BY 4.0

PLOS ONE Comparative analysis of ACE2 protein expression in rodent, non-human primate, and human respiratory tract at baseline and after injury: A conundrum for COVID-19 pathogenesis
February 24, 2021 Sourabh Soni, Yujie Jiang, Yohannes Tesfaigzi, Jason L. Hornick, Sule Çataltepe

Angiotensin converting enzyme 2 (ACE2) is the putative functional receptor for severe acute respiratory syndrome coronavirus 2…
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Fig 1. by Sun et al., CC BY 4.0

PLOS ONE Saliva as a testing specimen with or without pooling for SARS-CoV-2 detection by multiplex RT-PCR test
February 23, 2021 Qing Sun, Jonathan Li, Hui Ren, Larry Pastor, Yulia Loginova, Roberta Madej, Kristopher Taylor, Joseph K. Wong, Zhao Zhang, Aiguo Zhang, Chuanyi M. Lu, Michael Y. Sha

Background: Sensitive and high throughput molecular detection assays are essential during the coronavirus disease 2019 (COVID-19) pandemic,…
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Fig 1. Flowchart of the study design. by Flieder et al., CC BY 4.0

PLOS ONE Retrospective analysis of 426 donors of a convalescent collective after mild COVID-19
February 23, 2021 Tobias Flieder, Tanja Vollmer, Benjamin Müller, Jens Dreier, Bastian Fischer, Cornelius Knabbe, Ingvild Birschmann

Background: The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has…
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Fig 1. Flow cytometry gating strategy of microparticles (MPs). by Zahran et al., CC BY 4.0

PLOS ONE Circulating microparticles and activated platelets as novel prognostic biomarkers in COVID-19; relation to cancer
February 22, 2021 Asmaa M. Zahran, Omnia El-Badawy, Wageeh A. Ali, Zainab Gaber Mahran, Essam Eldeen M. O. Mahran, Amal Rayan

Background and aim: The study aimed to determine whether the MPs levels and platelet activation are affected by the COVID-19 infection in…
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Fig 1. Cycle threshold (Ct) values of fluorogenic real-time quantitative polymerase chain reaction (RT-qPCR) assay targeting the ORF1ab and N regions of SARS-CoV-2 on days after the last exposure for 10 independent cases. by Yuan et al., CC BY 4.0

PLOS ONE SARS-CoV-2 viral shedding characteristics and potential evidence for the priority for faecal specimen testing in diagnosis
February 22, 2021 Chen Yuan, Hongling Wang, Kefeng Li, An Tang, Yaxin Dai, Bing Wu, Hui Zhang, Jiabei Chen, Jienan Liu, Wenjie Wu, Songye Gu, Hai Wang, Haodi Xu, Mingyu Wu, Menglu Yu, Yuchao Wang, Xinwei Yu, Jialu He, Shelan Liu, Yongli Zhang, Zhendong Tong, Jianbo Yan

This study aimed to identify the specimen type that has high positivity and its proper sampling time for severe acute respiratory syndrome…
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Untitled by Ristić et al., CC BY 4.0

PLOS ONE Validation of the STANDARD Q COVID-19 antigen test in Vojvodina, Serbia
February 22, 2021 Mioljub Ristić, Nataša Nikolić, Velibor Čabarkapa, Vesna Turkulov, Vladimir Petrović

Background: Since COVID-19 pandemic is a global crisis, tests with high sensitivity and specificity are crucial for the identification and…
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Fig 2. Main effect of combined treatment of AZ and HCQ on viral carriage reduction. by Hulme et al., CC BY 4.0

PLOS ONE A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19
February 19, 2021 Oliver James Hulme, Eric-Jan Wagenmakers, Per Damkier, Christopher Fugl Madelung, Hartwig Roman Siebner, Jannik Helweg-Larsen, Quentin F. Gronau, Thomas Lars Benfield, Kristoffer Hougaard Madsen

Gautret and colleagues reported the results of a non-randomised case series which examined the effects of hydroxychloroquine and…
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Fig 2. A non-adherence tree (NAT). by Edifor et al., CC BY 4.0

PLOS ONE Non-Adherence Tree Analysis (NATA)—An adherence improvement framework: A COVID-19 case study
February 19, 2021 Ernest Edem Edifor, Regina Brown, Paul Smith, Rick Kossik

Poor medication adherence is a global phenomenon that has received a significant amount of research attention yet remains largely…
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Fig 2. Timeline of key events and public health interventions across the five stages of the COVID-19 epidemic in Thailand. by Triukose et al., CC BY 4.0

PLOS ONE Effects of public health interventions on the epidemiological spread during the first wave of the COVID-19 outbreak in Thailand
February 19, 2021 Sipat Triukose, Sirin Nitinawarat, Ponlapat Satian, Anupap Somboonsavatdee, Ponlachart Chotikarn, Thunchanok Thammasanya, Nasamon Wanlapakorn, Natthinee Sudhinaraset, Pitakpol Boonyamalik, Bancha Kakhong, Yong Poovorawan

A novel infectious respiratory disease was recognized in Wuhan (Hubei Province, China) in December 2019. I