Biology & Life Sciences

COVID-19 pandemic (2019-21)

Updated October 29, 2021 Curated Collections

This Collection of articles highlights all content published across the PLOS journals relating to the COVID-19 pandemic in 2019-21. PLOS is committed to disseminating research as quickly as possible, particularly in public health emergencies. All articles published in any PLOS journal are Open Access free of charge to all readers.

Image Credit: US NIH/Public domain (CC-0) and Senado Federal/Flickr (CC-BY)

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Clinical Epidemiology and Care

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2017_04_29_AMISOM constructs sanitation facility for community near AMISOM base-6 by AMISOM Public Information, CC 0

PLOS ONE Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients isolated in a community facility
September 27, 2021 Hui Mei Cheng, Xiahong Zhao, Wei Shyann Lim, Beatrice Jia Min Tan, Hong Liang Tey

Introduction: Mildly symptomatic cases of Covid-19 in previously-well individuals form the majority of infections and also serve as potent…
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10.1371/journal.pone.0257784 CC BY 4.0

PLOS ONE Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium
September 28, 2021 Rajaneesh K. Gupta, Enyinna L. Nwachuku, Benjamin E. Zusman, Ruchira M. Jha, Ava M. Puccio

Drug repurposing has the potential to bring existing de-risked drugs for effective intervention in an ongoing pandemic—COVID-19 that has…
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10.1371/journal.pmed.1003773 CC BY 4.0

PLOS Medicine Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19
September 28, 2021 Maxime Taquet, Quentin Dercon, Sierra Luciano, John R. Geddes, Masud Husain, Paul J. Harrison

Background: Long-COVID refers to a variety of symptoms affecting different organs reported by people following Coronavirus Disease 2019…
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6VSB spike protein SARS-CoV-2 homotrimer by 5-HT2AR, CC BY 0

PLOS ONE Risk for SARS-CoV-2 infection in healthcare workers outside hospitals: A real-life immuno-virological study during the first wave of the COVID-19 epidemic
September 28, 2021 Maria Fröberg, Sadaf Sakina Hassan, Ville N. Pimenoff, Susanne Akterin, Kalle Conneryd Lundgren, K. Miriam Elfström, Joakim Dillner

Objectives: Most COVID-19 related infections and deaths may occur in healthcare outside hospitals. Here we explored SARS-CoV-2 infections…
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10.1371/journal.pone.0257238 CC BY 4.0

PLOS ONE Hydroxychloroquine for the treatment of severe respiratory infection by COVID-19: A randomized controlled trial
September 28, 2021 Carmen Hernandez-Cardenas, Ireri Thirion-Romero, Sebastián Rodríguez-Llamazares, Norma E. Rivera-Martinez, Patricia Meza-Meneses, Arantxa Remigio-Luna, Rogelio Perez-Padilla, on behalf of the Research Group on hydroxychloroquine for COVID-19

Introduction: The novel coronavirus pandemic (COVID–19) represents a major public health problem and it is key to find a treatment that…
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10.1371/journal.pone.0257253 CC BY 4.0

PLOS ONE Risk factors, predictions, and progression of acute kidney injury in hospitalized COVID-19 patients: An observational retrospective cohort study
September 29, 2021 Maryam N. Naser, Rana Al-Ghatam, Abdulla H. Darwish, Manaf M. Alqahtani, Hajar A. Alahmadi, Khalifa A. Mohamed, Nahed K. Hasan, Nuria S. Perez

Objectives: Studies have shown that acute kidney injury (AKI) occurrence post SARS-CoV-2 infection is complex and has a poor prognosis.…
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10.1371/journal.pone.0257880 CC BY 4.0

PLOS ONE A scoping review of patient engagement activities during COVID-19: More consultation, less partnership
September 29, 2021 Lauren Cadel, Michelle Marcinow, Jane Sandercock, Penny Dowedoff, Sara J. T. Guilcher, Alies Maybee, Susan Law, Kerry Kuluski

Background: The COVID-19 pandemic has had a devastating impact on healthcare systems and care delivery, changing the context for patient…
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10.1371/journal.pone.0258015 CC BY 4.0

PLOS ONE Telehealth at scale can improve chronic disease management in the community during a pandemic: An experience at the time of COVID-19
September 29, 2021 Stefano Omboni, Tommaso Ballatore, Franco Rizzi, Fernanda Tomassini, Edoardo Panzeri, Luca Campolo

Background: During the COVID-19 pandemic, telehealth became a vital resource to contain the virus’s spread and ensure continuity of care of…
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10.1371/journal.pone.0258018 CC BY 4.0

PLOS ONE Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis
September 29, 2021 Martin Kieninger, Annemarie Sinning, Timea Vadász, Michael Gruber, Wolfram Gronwald, Florian Zeman, Dirk Lunz, Thomas Dienemann, Stephan Schmid, Bernhard Graf, Matthias Lubnow, Thomas Müller, Thomas Holzmann, Bernd Salzberger, Bärbel Kieninger

Background: Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects of the…
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10.1371/journal.pone.0257643 CC BY 4.0

PLOS ONE Geographical variation in demand, utilization, and outcomes of hospital services for COVID-19 in Brazil: A descriptive serial cross-sectional study
September 30, 2021 Claudia Cristina de Aguiar Pereira, Mônica Martins, Sheyla Maria Lemos Lima, Carla Lourenço Tavares de Andrade, Fernando Ramalho Gameleira Soares, Margareth Crisóstomo Portela

Objective: To analyze the geographical variation in the provision of health services, namely in demand, patterns of utilization, and…
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10.1371/journal.pone.0257845 CC BY 4.0

PLOS ONE Prevalence and risk factors for SARS-CoV-2 infection and seroprevalence among clinical and non-clinical staff in a national healthcare system
September 30, 2021 Moza Alishaq, Andrew Jeremijenko, Zeina Al-Kanaani, Hanaa Nafady-Hego, Diana H. Jboor, Rosaline Saba, Jameela Al-Ajmi, Nasser Asad Alansari, Anil George Thomas, Sameera Bihi Fareh, Suni Vinoy, Maryam Nooh, Nadya Alanzi, Abdul-Badi Abou-Samra, Adeel Ajwad Butt

Background: While many studies have reported the rate and risk of SARS-CoV-2 infection among healthcare workers (HCWs), there are scant…
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10.1371/journal.pone.0253072 CC BY 4.0

PLOS ONE Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is not detected in the vagina: A prospective study
September 30, 2021 Ozguc Takmaz, Eren Kaya, Burak Erdi, Gozde Unsal, Pari Sharifli, Nihat Bugra Agaoglu, Esra Ozbasli, Serap Gencer, Mete Gungor

Objective: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is present in the vagina of women diagnosed…
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10.1371/journal.pone.0258151 CC BY 4.0

PLOS ONE Aerosol SARS-CoV-2 in hospitals and long-term care homes during the COVID-19 pandemic
September 30, 2021 Gary Mallach, Samantha B. Kasloff, Tom Kovesi, Anand Kumar, Ryan Kulka, Jay Krishnan, Benoit Robert, Michaeline McGuinty, Sophia den Otter-Moore, Bashour Yazji, Todd Cutts

Background: Few studies have quantified aerosol concentrations of SARS-CoV-2 in hospitals and long-term care homes, and fewer still have…
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10.1371/journal.pone.0257458 CC BY 4.0

PLOS ONE Implementation of vascular surgery teleconsultation during the COVID-19 pandemic: Insights from the outpatient vascular clinics in a tertiary care hospital in Qatar
September 30, 2021 Hassan Al-Thani, Ahammed Mekkodathil, Ahmed Hussain, Ahmed Sharaf, Ahmed Sadek, Anas Aldakhl-Allah, Ahmed Awad, Nassar Al-Abdullah, Ahmad Zitoun, Jini Paul, Pushpalatha Pillai, Sara John, Ayman El-Menyar

Background: The COVID-19 pandemic has sparked a surge in the use of virtual communication tools for delivering clinical services for many…
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10.1371/journal.pone.0257910 CC BY 4.0

PLOS ONE The impact of COVID-19 pandemic on AMI and stroke mortality in Lombardy: Evidence from the epicenter of the pandemic
October 1, 2021 Camillo Rossi, Paolo Berta, Salvatore Curello, Pietro Giorgio Lovaglio, Mauro Magoni, Marco Metra, Aldo Maria Roccaro, Stefano Verzillo, Giorgio Vittadini

Background: The first Covid-19 epidemic outbreak has enormously impacted the delivery of clinical healthcare and hospital management…
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10.1371/journal.pone.0258236 CC BY 4.0

PLOS ONE Effect of a hospital-wide campaign on COVID-19 vaccination uptake among healthcare workers in the context of raised concerns for life-threatening side effects
October 1, 2021 Min Hyung Kim, Nak-Hoon Son, Yoon Soo Park, Ju Hyun Lee, Da Ae Kim, Yong Chan Kim

Background: All healthcare workers (HCWs) in Yongin Severance Hospital were allocated to receive the ChAdOx1 nCov-19 vaccine according to…
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10.1371/journal.pone.0257641 CC BY 4.0

PLOS ONE COVID-19-related outcomes in immunocompromised patients: A nationwide study in Korea
October 1, 2021 Moon Seong Baek, Min-Taek Lee, Won-Young Kim, Jae Chol Choi, Sun-Young Jung

Background: Given the rapid increased in confirmed coronavirus disease 2019 (COVID-19) and related mortality, it is important to identify…
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Hepatitis B and hand hold syringe by Marco Verch, CC BY 2.0

PLOS ONE Association between chronic hepatitis B infection and COVID-19 outcomes: A Korean nationwide cohort study
October 5, 2021 Seong Hee Kang, Dong-Hyuk Cho, Jimi Choi, Soon Koo Baik, Jun Gyo Gwon, Moon Young Kim

Background/Aims: We measured the association between underlying chronic hepatitis B (CHB) and antiviral use with infection rates among…
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10.1371/journal.pone.0258095 CC BY 4.0

PLOS ONE Altered mental status is a predictor of poor outcomes in COVID-19 patients: A cohort study
October 5, 2021 Abdallah S. Attia, Mohammad Hussein, Mohamed A. Aboueisha, Mahmoud Omar, Mohanad R. Youssef, Nicholas Mankowski, Michael Miller, Ruhul Munshi, Aubrey Swinford, Adam Kline, Therese Nguyen, Eman Toraih, Juan Duchesne, Emad Kandil

Introduction: Several studies have described typical clinical manifestations, including fever, cough, diarrhea, and fatigue with COVID-19…
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Healthcare worker donning the final article of personal protective equipment (PPE), a plastic apron, which would complete his protective uniform by Centers for Disease Control and Prevention, CC 0

PLOS ONE Assessment of knowledge, attitude and practice toward COVID-19 and associated factors among health care workers in Silte Zone, Southern Ethiopia
October 5, 2021 Mubarek Yesse, Mohammed Muze, Shemsu Kedir, Bedru Argaw, Mohammed Dengo, Tajudin Nesre, Faris Hamdalla, Awol Saliha, Tofik Mussa, India Kasim, Abdulfeta Kedir, Tofik Delebo, Awol Sunkemo, Yesuf Badeg, Dureti Ensarmu, Dereje Abebe, Amara Dessalegn, Henok Ayelign

Introduction: COVID-19 is a pandemic respiratory disease caused by the highly contagious novel coronavirus (SARS-CoV 2). The disease is now…
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Symptoms of coronavirus disease 2019 (cropped) by Mikael Häggström, M.D., CC 0

PLOS ONE Severe COVID-19 in inflammatory bowel disease patients in a population-based setting
October 5, 2021 Rob H. Creemers, Ashkan Rezazadeh Ardabili, Daisy M. Jonkers, Mathie P. G. Leers, Mariëlle J. Romberg-Camps, Marie J. Pierik, Ad A. van Bodegraven

Objective: Data on the course of severe COVID-19 in inflammatory bowel disease (IBD) patients remains limited. We aimed to determine the…
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10.1371/journal.pone.0257807 CC BY 4.0

PLOS ONE COVID-19 in lung transplant recipients—Risk prediction and outcomes
October 6, 2021 Jan C. Kamp, Jan B. Hinrichs, Jan Fuge, Raphael Ewen, Jens Gottlieb

Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in…
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10.1371/journal.pone.0258278 CC BY 4.0

PLOS ONE Comprehensive evaluation of COVID-19 patient short- and long-term outcomes: Disparities in healthcare utilization and post-hospitalization outcomes
October 6, 2021 Stephen Salerno, Yuming Sun, Emily L. Morris, Xinwei He, Yajing Li, Ziyang Pan, Peisong Han, Jian Kang, Michael W. Sjoding, Yi Li

Background: Understanding risk factors for short- and long-term COVID-19 outcomes have implications for current guidelines and practice. We…
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10.1371/journal.pone.0245103 CC BY 4.0

PLOS ONE Disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic in March–October 2020: An exploratory analysis
October 6, 2021 Martin Modrák, Paul-Christian Bürkner, Tomáš Sieger, Tomáš Slisz, Martina Vašáková, Grigorij Mesežnikov, Luis Fernando Casas-Mendez, Jaromír Vajter, Jan Táborský, Viktor Kubricht, Daniel Suk, Jan Horejsek, Martin Jedlička, Adriana Mifková, Adam Jaroš, Miroslav Kubiska, Jana Váchalová, Robin Šín, Markéta Veverková, Zbyšek Pospíšil, Julie Vohryzková, Rebeka Pokrievková, Kristián Hrušák, Kristína Christozova, Vianey Leos-Barajas, Karel Fišer, Tomáš Hyánek

We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested…
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10.1371/journal.pone.0257302 CC BY 4.0

PLOS ONE Reduced turnaround times through multi-sectoral community collaboration during the first surge of SARS-CoV-2 and associated effect on patient care and hospital operations
October 7, 2021 Rebecca C. Christofferson, Hollis R. O’Neal, Tonya Jagneaux, Catherine O’Neal, Christine S. Walsh, E. Handly Mayton, Luan D. Vu, Abigail I. Fish, Anh Phan, Thaya E. Stoufflet, Jonathan R. Schroeder, Morgan Walker, Erik A. Turner, Christi Pierce, K. Scott Wester, Connie DeLeo, Edgardo Tenreiro, Beverly Ogden, Stephania A. Cormier

Background: In March 2020, an influx of admissions in COVID-19 positive patients threatened to overwhelm healthcare facilities in East…
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10.1371/journal.pone.0258260 CC BY 4.0

PLOS ONE Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study
October 8, 2021 Ezequiel Cordova, Analia Mykietiuk, Omar Sued, Lautaro De Vedia, Natalia Pacifico, Matias H. Garcia Hernandez, Natalia M. Baeza, Franco Garibaldi, Maria Fernanda Alzogaray, Rosa Contreras, Lucrecia Soler Puy, Pablo G. Scapellato, Laura Barcelona, Mariana L. Golikow, Maria Florencia Piñeiro, Hugo J. Miño, Maria Fernanda Consalvo, Corina Nemirovsky, Marisa Sanchez, Myrna Cabral, Lucia Lamponi Tappata, Mariano Blasco, Jamile Ballivian, Gustavo Lopardo, Martin E. Stryjewski, on behalf of the ECCOVID study group

Background: Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe…
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10.1371/journal.pone.0258452 CC BY 4.0

PLOS ONE Disparities in telemedicine utilization among surgical patients during COVID-19
October 8, 2021 Courtney M. Lattimore, William J. Kane, Mark A. Fleming II, Allison N. Martin, J. Hunter Mehaffey, Mark E. Smolkin, Sarah J. Ratcliffe, Victor M. Zaydfudim, Shayna L. Showalter, Traci L. Hedrick

Background: Telemedicine has been rapidly adopted in the wake of the COVID-19 pandemic. There is limited work surrounding demographic and…
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10.1371/journal.pone.0257926 CC BY 4.0

PLOS ONE Impacts of mild COVID-19 on elevated use of primary and specialist health care services: A nationwide register study from Norway
October 8, 2021 Katrine Damgaard Skyrud, Kjersti Helene Hernæs, Kjetil Elias Telle, Karin Magnusson

Aim: To explore the temporal impact of mild COVID-19 on need for primary and specialist health care services. Methods: In all adults (≥20…
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10.1371/journal.pone.0258255 CC BY 4.0

PLOS ONE Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study
October 8, 2021 Beesan Maraqa, Walid Basha, Rasha Khayyat, Abdul-Rahman Abdul-Hadi, Jurouh Jabareen, Kamal Al-Shakhra, Mai Al-Kaila, Zaher Nazzal

This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north,…
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10.1371/journal.pone.0257513 CC BY 4.0

PLOS ONE Comprehensive infection control measures prevent hospital-acquired severe acute respiratory syndrome coronavirus 2 infection: A single-center prospective cohort study and seroprevalence survey
October 11, 2021 Hiroshi Hori, Takahiko Fukuchi, Masamitsu Sanui, Takashi Moriya, Hitoshi Sugawara

Background: Coronavirus disease (COVID-19) is associated with a high mortality rate in older adults; therefore, it is important for medical…
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10.1371/journal.pone.0258513 CC BY 4.0

PLOS ONE Increased risk of hospitalisation and intensive care admission associated with reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December 2020 –May 2021
October 11, 2021 Lamprini Veneti, Elina Seppälä, Margrethe Larsdatter Storm, Beatriz Valcarcel Salamanca, Eirik Alnes Buanes, Nina Aasand, Umaer Naseer, Karoline Bragstad, Olav Hungnes, Håkon Bøås, Reidar Kvåle, Karan Golestani, Siri Feruglio, Line Vold, Karin Nygård, Robert Whittaker

Introduction: Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk…
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10.1371/journal.pmed.1003816 CC BY 4.0

PLOS Medicine Transmission of community- and hospital-acquired SARS-CoV-2 in hospital settings in the UK: A cohort study
October 12, 2021 Yin Mo, David W. Eyre, Sheila F. Lumley, Timothy M. Walker, Robert H. Shaw, Denise O’Donnell, Lisa Butcher, Katie Jeffery, Christl A. Donnelly, Oxford COVID infection review team , Ben S. Cooper

Background: Nosocomial spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been widely reported, but the…
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Chicago Lakeshore View Aerial by Carol M Highsmith, CC 0

PLOS ONE COVID-19 health inequities and association with mechanical ventilation and prolonged length of stay at an urban safety-net health system in Chicago
October 13, 2021 Jacquelyn Jacobs, Amy K. Johnson, Arianna Boshara, Bijou Hunt, Christina Khouri, Javier Cruz, Nancy Glick

Millions of Americans have been infected with COVID-19 and communities of color have been disproportionately burdened. We investigated the…
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10.1371/journal.pone.0258478 CC BY 4.0

PLOS ONE Patient attendance at a pediatric emergency referral hospital in an area with low COVID-19 incidence
October 14, 2021 Koichi Shichijo, Shunsuke Takeuchi, Takahiro Tayama, Mikiko Takei, Keisuke Fujioka, Akemi Ono, Miki Shono, Kenichi Suga, Reiko Kondo, Takashi Kaimen, Nobuo Arima, Shuji Kondo

The purpose of this study was to clarify the effects of individual infection control measures and physical distancing on pediatric medical…
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10.1371/journal.pone.0257982 CC BY 4.0

PLOS ONE J-waves in acute COVID-19: A novel disease characteristic and predictor of mortality?
October 14, 2021 Naufal Shamilevich Zagidullin, Lukas J. Motloch, Timur Ilgamovich Musin, Zilya Adibovna Bagmanova, Irina Alexandrovna Lakman, Anton Viktorovich Tyurin, Ruslan Mansurovich Gumerov, Dinar Enikeev, Benzhi Cai, Diana Firdavisovna Gareeva, Paruir Artakovich Davtyan, Damir Aidarovich Gareev, Halima Malikovna Talipova, Marat Rifkatovich Badykov, Peter Jirak, Kristen Kopp, Uta C. Hoppe, Rudin Pistulli, Valentin Nikolaevich Pavlov

Background: J-waves represent a common finding in routine ECGs (5–6%) and are closely linked to ventricular tachycardias. While arrhythmias…
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10.1371/journal.pone.0258671 CC BY 4.0

PLOS ONE Clinical and epidemiological characteristics of patients seeking COVID-19 testing in a private centre in Malaysia: Is there a role for private healthcare in battling the outbreak?
October 14, 2021 Yock Ping Chow, Brenda Huey Zien Chin, Jin Ming Loo, Loshini R. Moorthy, Jamuna Jairaman, Lian Huat Tan, Wendy Wan Ying Tay

Objective: This cross-sectional observational study summarized the baseline characteristics of subjects who underwent COVID-19 molecular…
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10.1371/journal.pmed.1003820 CC BY 4.0

PLOS Medicine HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study
October 14, 2021 Rita Bergqvist, Viktor H. Ahlqvist, Michael Lundberg, Maria-Pia Hergens, Johan Sundström, Max Bell, Cecilia Magnusson

Background: The relationship between statin treatment and Coronavirus Disease 2019 (COVID-19) mortality has been discussed due to the…
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10.1371/journal.pone.0257892 CC BY 4.0

PLOS ONE Association of abnormal pulmonary vasculature on CT scan for COVID-19 infection with decreased diffusion capacity in follow up: A retrospective cohort study
October 15, 2021 Daniel Salerno, Ifeoma Oriaku, Melinda Darnell, Maarten Lanclus, Jan De Backer, Ben Lavon, Rohit Gupta, Fredric Jaffe, Maria Elena Vega Sanchez, Victor Kim, on behalf of the Temple University Covid-19 Research Group

Background: Coronavirus Disease 2019 (COVID-19) is a respiratory viral illness causing pneumonia and systemic disease. Abnormalities in…
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6VSB spike protein SARS-CoV-2 monomer by 5-HT2AR, CC 0

PLOS ONE Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers
October 15, 2021 Moza Alishaq, Hanaa Nafady-Hego, Andrew Jeremijenko, Jameela Ali Al Ajmi, Mohamed Elgendy, Suni Vinoy, Sameera Bihi Fareh, Justine Veronica Plaatjies, Mariam Nooh, Nadya Alanzi, Anvar H. Kaleeckal, Ali Nizar Latif, Peter Coyle, Hamed Elgendy, Abdul-Badi Abou-Samra, Adeel Ajwad Butt

Background and objective: The risk factors for breakthrough infections among healthcare workers (HCW) after completion of a full course of…
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10.1371/journal.pone.0258754 CC BY 4.0

PLOS ONE Feasibility of CPAP application and variables related to worsening of respiratory failure in pregnant women with SARS-CoV-2 pneumonia: Experience of a tertiary care centre
October 19, 2021 Paola Faverio, Sara Ornaghi, Anna Stainer, Francesca Invernizzi, Mara Borelli, Federica Brunetti, Laura La Milia, Valentina Paolini, Roberto Rona, Giuseppe Foti, Fabrizio Luppi, Patrizia Vergani, Alberto Pesci

Continuous positive airway pressure (CPAP) has been successfully applied to patients with COVID-19 to prevent endotracheal intubation.…
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10.1371/journal.pone.0257978 CC BY 4.0

PLOS ONE Understanding an evolving pandemic: An analysis of the clinical time delay distributions of COVID-19 in the United Kingdom
October 20, 2021 Thomas Ward, Alexander Johnsen

Understanding and monitoring the epidemiological time delay dynamics of SARS-CoV-2 infection provides insights that are key to discerning…
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Top view dessert of ice cream, chocolate cake and strawberry juice on wooden table in restaurant by Nenad Stojkovic, CC BY 2.0

PLOS ONE Altered smell and taste: Anosmia, parosmia and the impact of long Covid-19
September 24, 2021 Duika L. Burges Watson, Miglena Campbell, Claire Hopkins, Barry Smith, Chris Kelly, Vincent Deary

Background: Qualitative olfactory (smell) dysfunctions are a common side effect of post-viral illness and known to impact quality of life…
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Hospital by Sergio Santos, CC BY 2.0

PLOS ONE Predictors of severity and development of critical illness of Egyptian COVID-19 patients: A multicenter study
September 23, 2021 Dalia Omran, Mohamed Al Soda, Eshak Bahbah, Gamal Esmat, Hend Shousha, Ahmed Elgebaly, Muhammad Abdel Ghaffar, Mohamed Alsheikh, Enass El Sayed, Shimaa Afify, Samah Abdel Hafez, Khaled Elkelany, Ayman Eltayar, Omnia Ali, Lamiaa Kamal, Ahmed Heiba

Objectives: We conducted the present multicenter, retrospective study to assess the epidemiological, clinical, laboratory, and radiological…
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Fig 3. Summary comparison of seroprevalence rates by analytical methods by Saeed et al., CC BY 4.0

PLOS ONE Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence: Navigating the absence of a gold standard
September 23, 2021 Sahar Saeed, Sheila F. O’Brien, Kento Abe, Qi-Long Yi, Bhavisha Rathod, Jenny Wang, Mahya Fazel-Zarandi, Ashleigh Tuite, David Fisman, Heidi Wood, Karen Colwill, Anne-Claude Gingras, Steven J. Drews

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence studies bridge the gap left from case detection, to…
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Fig 2. Clinical course of SARS-CoV-2 pneumonia 6 months follow-up in primary care (2020). by Ares-Blanco et al., CC BY 4.0

PLOS ONE SARS-CoV-2 pneumonia follow-up and long COVID in primary care: A retrospective observational study in Madrid city
September 22, 2021 Sara Ares-Blanco, Marta Pérez Álvarez, Ileana Gefaell Larrondo, Cristina Muñoz, Vanesa Aguilar Ruiz, Marta Castelo Jurado, Marina Guisado-Clavero

Background: Patients with COVID-19 are follow-up in primary care and long COVID is scarcely defined. The study aim was to describe…
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plants by vinod velayudhan, CC BY 2.0

PLOS ONE Use of medicinal plants for COVID-19 prevention and respiratory symptom treatment during the pandemic in Cusco, Peru: A cross-sectional survey
September 22, 2021 Magaly Villena-Tejada, Ingrid Vera-Ferchau, Anahí Cardona-Rivero, Rina Zamalloa-Cornejo, Maritza Quispe-Florez, Zany Frisancho-Triveño, Rosario C. Abarca-Meléndez, Susan G. Alvarez-Sucari, Christian R. Mejia, Jaime A. Yañez

Background: The burden of the COVID-19 pandemic in Peru has led to people seeking alternative treatments as preventives and treatment…
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Fig 1. Radar chart of readiness scores (%) of 13 components of WHO modified COVID-19 hospital readiness checklist among 20 hospitals in Nigeria by Ogoina et al., CC BY 4.0

PLOS ONE A national survey of hospital readiness during the COVID-19 pandemic in Nigeria
September 21, 2021 Dimie Ogoina, Dalhat Mahmood, Abisoye Sunday Oyeyemi, Ogochukwu Chinedum Okoye, Vivian Kwaghe, Zayaid Habib, Uche Unigwe, Michael Onyebuchi Iroezindu, Musa Abubakar Garbati, Stella Rotifa, Olukemi Adekanmbi, Iliyasu Garba, Farouq Muhammad Dayyab, Sanusi Mohammed Ibrahim, Ibrahim Musa Kida, Adamu Adamu, Datonye Alasia, Sati Klein Awang, John Oghenevwirhe Ohaju-Obodo, Rabi Usman, Yahaya Mohammed, Ayanfe Omololu, Ekaete Alice Tobin, Sylvanus Okogbenin, Danny Asogun, Iraoyah Kelly, Bala Waziri, Aliyu Mamman Nauzo, Yusuf Jibrin, Abdulrazaq Garba Habib

Introduction: The COVID-19 pandemic continues to overwhelm health systems across the globe. We aimed to assess the readiness of hospitals…
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Fig 1. Anti-SARS-CoV-2 IgG and IgM antibody response in symptomatic pregnant women by Glennon et al., CC BY 4.0

PLOS ONE Immunological assessment of SARS-CoV-2 infection in pregnancy from diagnosis to delivery: A multicentre prospective study
September 20, 2021 Kate Glennon, Jennifer Donnelly, Susan Knowles, Fionnuala M. McAuliffe, Alma O’Reilly, Siobhan Corcoran, Jennifer Walsh, Roger McMorrow, Tess Higgins, Lucy Bolger, Susan Clinton, Sarah O’Riordan, Alexander Start, Doireann Roche, Helena Bartels, Ciara Malone, Karl McAuley, Anthony McDermott, Rosanna Inzitari, Colm P. F. O’Donnell, Fergal Malone, Shane Higgins, Cillian De Gascun, Peter Doran, Donal J. Brennan

Background: Background Population-based data on SARS-CoV-2 infection in pregnancy and assessment of passive immunity to the neonate, is…
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Fig 1. The Sani nudge hygiene system in a hospital patient room by Hüttel et al., CC BY 4.0

PLOS ONE Analysis of social interactions and risk factors relevant to the spread of infectious diseases at hospitals and nursing homes
September 20, 2021 Frederik Boe Hüttel, Anne-Mette Iversen, Marco Bo Hansen, Bjarne Kjær Ersbøll, Svend Ellermann-Eriksen, Niels Lundtorp Olsen

Ensuring the safety of healthcare workers is vital to overcome the ongoing COVID-19 pandemic. We here present an analysis of the social…
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Fig 2. Perceptions of cancer care quality during COVID-19 from cancer patients, survivors and carers by Edge et al., CC BY 4.0

PLOS ONE Cancer care disruption and reorganisation during the COVID-19 pandemic in Australia: A patient, carer and healthcare worker perspective
September 17, 2021 Rhiannon Edge, Josh Meyers, Gabriella Tiernan, Zhicheng Li, Alexandra Schiavuzzi, Priscilla Chan, Amy Vassallo, April Morrow, Carolyn Mazariego, Claire E. Wakefield, Karen Canfell, Natalie Taylor

The COVID-19 pandemic has dramatically impacted cancer care worldwide. Disruptions have been seen across all facets of care. While the…
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Home Heart Rate Monitor - Finger Pulse Checker and a Stethoscope by www.doctor-4-u.co.uk, CC BY 2.0

PLOS ONE Study protocol of the PEruvian Registry of ST-segment Elevation Myocardial Infarction II (PERSTEMI-II) study
September 17, 2021 Manuel Chacón-Díaz, Akram Hernández-Vásquez, Rodrigo Vargas-Fernández, Guido Bendezu-Quispe

Background: Myocardial infarction (MI) is the most prevalent cardiovascular disease globally and is considered a public health problem. In…
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Fig 1. Map of Ghana showing the Tamale teaching hospital and the SARS-CoV-2 PCR testing facilities used in this study by Nuertey et al., CC BY 4.0

PLOS ONE Performance of COVID-19 associated symptoms and temperature checking as a screening tool for SARS-CoV-2 infection
September 17, 2021 Benjamin Demah Nuertey, Kwame Ekremet, Abdul-Rashid Haidallah, Kareem Mumuni, Joyce Addai, Rosemary Ivy E. Attibu, Michael C. Damah, Elvis Duorinaa, Anwar Sadat Seidu, Victor C. Adongo, Richard Kujo Adatsi, Hisyovi Caedenas Suri, Abass Abdul-Karim Komei, Braimah Baba Abubakari, Enoch Weyori, Emmanuel Allegye-Cudjoe, Augustina Sylverken, Michael Owusu, Richard O. Phillips

Introduction: Coronavirus disease-19 (COVID-19), which started in late December, 2019, has spread to affect 216 countries and territories…
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Fig 1 by Hewamana et al., CC BY 4.0

PLOS ONE Blood cancer care in a resource limited setting during the Covid-19 outbreak; a single center experience from Sri Lanka
September 17, 2021 Saman Hewamana, Thurairajah Skandarajah, Chathuri Jayasinghe, Samadhi Deshapriya, Dhananjani Senarathna, Gehan Arseculeratne, Mahesh Harischandra, Gnani Somasundaram, Vadivelu Srinivasan, Surjit Somiah, Nihal Munasinghe, Sangeetha Hewawasam, Lalith Ekanayake, Rohini Wadanamby, Geethani Galagoda, Thet Thet Lin, Jayantha Balawardena

Background: The Covid-19 pandemic has caused significant morbidity and mortality among patients with cancer. Most countries employed…
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Inauguración del Hospital Municipal de Chiconcuac by Presidencia de la Repúblic, CC BY 2.0

PLOS ONE The potential impact of triage protocols on racial disparities in clinical outcomes among COVID-positive patients in a large academic healthcare system
September 16, 2021 Shireen Roy, Mary Showstark, Benjamin Tolchin, Nitu Kashyap, Jennifer Bonito, Michelle C. Salazar, Jennifer L. Herbst, Katherine A. Nash, Max Jordan Nguemeni Tiako, Karen Jubanyik, Nancy Kim, Deron Galusha, Karen H. Wang, Carol Oladele

Background: The COVID-19 pandemic has had a devastating impact in the United States, particularly for Black populations, and has heavily…
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Fig 2. No association between SARS-CoV-2 neutralizing antibodies and fatal outcome in critically ill COVID-19 patients by Youngs et al., CC BY 4.0

PLOS Pathogens Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients
September 16, 2021 Jonathan Youngs, Nicholas M. Provine, Nicholas Lim, Hannah R. Sharpe, Ali Amini, Yi-Ling Chen, Jian Luo, Matthew D. Edmans, Panagiota Zacharopoulou, Wentao Chen, Oliver Sampson, Robert Paton, William J. Hurt, David A. Duncan, Anna L. McNaughton, Vincent N. Miao, Susannah Leaver, Duncan L. A. Wyncoll, Jonathan Ball, Philip Hopkins, Oxford Immunology Network Covid-19 response T cell Consortium , Oxford Protective T cell Immunology for COVID-19 (OPTIC) Clinical team , Donal T. Skelly, Eleanor Barnes, Susanna Dunachie, Graham Ogg, Teresa Lambe, Ian Pavord, Alex K. Shalek, Craig P. Thompson, Luzheng Xue, Derek C. Macallan, Philip Goulder, Paul Klenerman, Tihana Bicanic

Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth…
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Fig 1. Changes of refractive error, axial length, and questionnaire before and after coronavirus disease 2019 according to children’s age by Yum et al., CC BY 4.0

PLOS ONE Influence of coronavirus disease 2019 on myopic progression in children treated with low-concentration atropine
September 14, 2021 Hae Ri Yum, Shin Hae Park, Sun Young Shin

Purpose: The outbreak of coronavirus disease 2019 (COVID-19) has caused many children to stay indoors. Increased near work and insufficient…
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Fig 1. Different duration of illness prior to the admission (n = 385, 62.30% of COVOCA cohort) by Pafundi et al., CC BY 4.0

PLOS ONE Lack of effect on in-hospital mortality of drugs used during COVID-19 pandemic: Findings of the retrospective multicenter COVOCA study
September 14, 2021 Pia Clara Pafundi, Raffaele Galiero, Vittorio Simeon, Luca Rinaldi, Alessandro Perrella, Erica Vetrano, Alfredo Caturano, Maria Alfano, Domenico Beccia, Riccardo Nevola, Raffaele Marfella, Celestino Sardu, Carmine Coppola, Ferdinando Scarano, Paolo Maggi, Pellegrino De Lucia Sposito, Laura Vocciante, Carolina Rescigno, Costanza Sbreglia, Fiorentino Fraganza, Roberto Parrella, Annamaria Romano, Giosuele Calabria, Benedetto Polverino, Antonio Pagano, Carolina Bologna, Maria Amitrano, Vincenzo Esposito, Nicola Coppola, Nicola Maturo, Luigi Elio Adinolfi, Paolo Chiodini, Ferdinando Carlo Sasso, on behalf of COVOCA Study Group

Introduction: During COVID-19 pandemic, the use of several drugs has represented the worldwide clinical practice. However, though the…
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A doctor holding a magnifying glass. by Nenad Stojkovic, CC BY 2.0

PLOS ONE Examining and investigating the impact of demographic characteristics and chronic diseases on mortality of COVID-19: Retrospective study
September 10, 2021 Abbas Al Mutair, Alya Al Mutairi, Saad Alhumaid, Syed Maaz Abdullah, Abdul Rehman Zia Zaidi, Ali A. Rabaan, Awad Al-Omari

Background: Epidemiological features characterization of COVID-19 is highly important for developing and implementing effective control…
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Stethoscope and heartbeats on red by Marco Verch, CC BY 2.0

PLOS ONE Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study
September 10, 2021 Ricardo Costeira, Karla A. Lee, Benjamin Murray, Colette Christiansen, Juan Castillo-Fernandez, Mary Ni Lochlainn, Joan Capdevila Pujol, Heather Macfarlane, Louise C. Kenny, Iain Buchan, Jonathan Wolf, Janice Rymer, Sebastien Ourselin, Claire J. Steves, Timothy D. Spector, Louise R. Newson, Jordana T. Bell

It has been widely observed that adult men of all ages are at higher risk of developing serious complications from COVID-19 when compared…
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Fig 2. Gross pathology of macroscopic hemorrhages by Santana et al., CC BY 4.0

PLOS ONE Hemorrhagic and thrombotic manifestations in the central nervous system in COVID-19: A large observational study in the Brazilian Amazon with a complete autopsy series
September 10, 2021 Monique Freire Santana, Carlos Henrique Michiles Frank, Taynná Vernalha Rocha Almeida, Christiane Maria Prado Jeronimo, Rebecca Augusta de Araújo Pinto, Yasmin Ferreira Martins, Maria Eduarda Leão de Farias, Bruna Guimarães Dutra, José Diego Brito-Sousa, Djane Clarys Baía-da-Silva, Mariana Simão Xavier, Marcus Vinicius Guimarães Lacerda, Fernando Fonseca Almeida Val, Gisely Cardoso Monteiro, Vanderson de Souza Sampaio, Wuelton Marcelo Monteiro, Luiz Carlos de Lima Ferreira

SARS-CoV-2 affects mainly the lungs, however, other manifestations, including neurological manifestations, have also been described during…
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Doctor explains cardiogram data, consultation by Marco Verch, CC BY 2.0

PLOS ONE Real-life use of tocilizumab with or without corticosteroid in hospitalized patients with moderate-to-severe COVID-19 pneumonia: A retrospective cohort study
September 10, 2021 Gianluca Russo, Angelo Solimini, Paola Zuccalà, Maria Antonella Zingaropoli, Anna Carraro, Patrizia Pasculli, Valentina Perri, Raffaella Marocco, Blerta Kertusha, Cosmo Del Borgo, Emanuela Del Giudice, Laura Fondaco, Tiziana Tieghi, Claudia D’Agostino, Alessandra Oliva, Vincenzo Vullo, Maria Rosa Ciardi, Claudio Maria Mastroianni, Miriam Lichtner

Objective: To evaluate the effectiveness of Tocilizumab (with or without corticosteroids) in a real-life context among moderate-to-severe…
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Fig 1. Emergency departments in the Netherlands (June 2020) by O’Connor et al., CC BY 4.0

PLOS ONE Preparations of Dutch emergency departments for the COVID-19 pandemic: A questionnaire-based study
September 10, 2021 Rory D. O’Connor, Dennis G. Barten, Gideon H. P. Latten

Background: The onset of the COVID-19 pandemic was characterized by rapid increases in Emergency department (ED) patient visits. EDs…
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Medical consultation by sergio santos, CC BY 2.0

PLOS ONE Enabling teleophthalmology during the COVID-19 pandemic in the Province of Trento, Italy: Design and implementation of a mHealth solution
September 10, 2021 Giulia Malfatti, Elisabetta Racano, Roberta Delle Site, Lorenzo Gios, Stefano Micocci, Marco Dianti, Pietro Benedetto Molini, Francesca Allegrini, Mariangela Ravagni, Monica Moz, Andrea Nicolini, Federica Romanelli

Background: Due to the many restrictions imposed during the COVID-19 emergency, the normal clinical activities have been stopped abruptly…
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Working place of a coronavirus vaccination center worker by Marco Verch, CC BY 2.0

PLOS ONE Statins use and COVID-19 outcomes in hospitalized patients
September 10, 2021 Samuel K. Ayeh, Enoch J. Abbey, Banda A. A. Khalifa, Richard D. Nudotor, Albert Danso Osei, Vignesh Chidambaram, Ngozi Osuji, Samiha Khan, Emmanuella L. Salia, Modupe O. Oduwole, Hasiya E. Yusuf, Oluwatobi Lasisi, Esosa Nosakhare, Petros C. Karakousis

Background: There is an urgent need for novel therapeutic strategies for reversing COVID-19-related lung inflammation. Recent evidence has…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain 1.0

PLOS ONE Elevated C-reactive protein in early COVID-19 predicts worse survival among hospitalized geriatric patients
September 10, 2021 Adeline Villoteau, Marine Asfar, Marie Otekpo, Jocelyne Loison, Jennifer Gautier, Cédric Annweiler, on behalf of the GERIA-COVID study group

Background: The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality…
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Gloves and disposable medical mask on a white background by Marco Verch, CC BY 2.0

PLOS ONE Health knowledge, health behaviors and attitudes during pandemic emergencies: A systematic review
September 7, 2021 Fabio Alexis Rincón Uribe, Rejane Célia de Souza Godinho, Marcos Antonio Santos Machado, Kleber Roberto da Silva Gonçalves Oliveira, Cristian Ariel Neira Espejo, Natalia Carvalho Vianna de Sousa, Leonardo Lucas de Sousa, Marcos Vinicius Monteiro Barbalho, Pedro Paulo Freire Piani, Janari da Silva Pedroso

Background: People with good health knowledge present a conceptual and objective appropriation of general and specific health topics,…
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Doctor chest with stethoscope in pocket by www.authoritydental.org., CC BY 2.0

PLOS ONE Nurses’ perspectives of taking care of patients with Coronavirus disease 2019: A phenomenological study
September 3, 2021 Sarath Rathnayake, Damayanthi Dasanayake, Sujeewa Dilhani Maithreepala, Ramya Ekanayake, Pradeepa Lakmali Basnayake

The pandemic of Coronavirus disease 2019 (COVID-19) has brought significant pressure on nurses globally as they are the frontline of care.…
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Fig 1. Percentage of select characteristics among laboratory-confirmed COVID-19 patients with diabetes mellitus (DM), by hospitalization status (n = 54)—Colorado, March 2020 by Vahey et al., CC BY 4.0

PLOS ONE Risk factors for hospitalization among persons with COVID-19—Colorado
September 2, 2021 Grace M. Vahey, Emily McDonald, Kristen Marshall, Stacey W. Martin, Helen Chun, Rachel Herlihy, Jacqueline E. Tate, Breanna Kawasaki, Claire M. Midgley, Nisha Alden, Marie E. Killerby, J. Erin Staples, on behalf of the Colorado Investigation Team

Background: Most current evidence on risk factors for hospitalization because of coronavirus disease 2019 (COVID-19) comes from studies…
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Walking by Abhijit Kar Gupta, CC BY 2.0

PLOS ONE Pulmonary function and six-minute-walk test in patients after recovery from COVID-19: A prospective cohort study
September 2, 2021 Dararat Eksombatchai, Thananya Wongsinin, Thanyakamol Phongnarudech, Kanin Thammavaranucupt, Naparat Amornputtisathaporn, Somnuek Sungkanuparph

Objectives: To study abnormality of spirometry, six-minute walk distance, and chest radiograph among patients recovered from Coronavirus…
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Fig 2. Boxplots of significant differences in physiological respiratory parameters, hospital admissions and COVID-19 by Mälberg et al., CC BY 4.0

PLOS ONE Physiological respiratory parameters in pre-hospital patients with suspected COVID-19: A prospective cohort study
September 2, 2021 Johan Mälberg, Nermin Hadziosmanovic, David Smekal

Background: The COVID-19 pandemic has presented emergency medical services (EMS) worldwide with the difficult task of identifying patients…
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Fig 2. Rate of ICU admission, intubation, ECMO induction, and mortality according to group by Shionoya et al., CC BY 4.0

PLOS ONE Possibility of deterioration of respiratory status when steroids precede antiviral drugs in patients with COVID-19 pneumonia: A retrospective study
September 2, 2021 Yu Shionoya, Toshibumi Taniguchi, Hajime Kasai, Noriko Sakuma, Shun Imai, Kohei Shikano, Shin Takayanagi, Misuzu Yahaba, Taka-aki Nakada, Hidetoshi Igari, Seiichiro Sakao, Takuji Suzuki

Introduction: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Although most patients with…
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Fig 1. Study area: To show where the region is located (sourced self) by Desta et al., CC BY 4.0

PLOS ONE Impacts of COVID-19 on essential health services in Tigray, Northern Ethiopia: A pre-post study
August 27, 2021 Abraham Aregay Desta, Tewolde Wubayehu Woldearegay, Estifanos Gebremeskel, Mussie Alemayehu, Theodros Getachew, Gebremedhin Gebregzabiher, Kiros Demoz Ghebremedhin, Degnesh Negash Zgita, Abera Berhe Aregawi, Getachew Redae

Background: COVID-19 has proved to have an indirect impact on essential health services in several parts of the world which could lead to…
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Fig 2. Assessment of methodological quality by Du et al., CC BY 4.0

PLOS ONE Add-on effect of Chinese herbal medicine in the treatment of mild to moderate COVID-19: A systematic review and meta-analysis
August 20, 2021 Xuqin Du, Lipeng Shi, Wenfu Cao, Biao Zuo, Aimin Zhou

Introduction: Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic since its outbreak in Wuhan, China. It is an urgent task…
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Working place of a coronavirus vaccination center worker by Marco Verch, CC BY 2.0

PLOS ONE COVID-19 pandemic: Impact on the management of patients with hepatocellular carcinoma at a tertiary care hospital
August 26, 2021 Katharina Pomej, Bernhard Scheiner, Lukas Hartl, Lorenz Balcar, Tobias Meischl, Mattias Mandorfer, Thomas Reiberger, Christian Müller, Michael Trauner, Matthias Pinter

Background: Patients with hepatocellular carcinoma (HCC) represent a vulnerable population potentially negatively affected by…
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Fig 1. ROC curve for D-dimer as a predictor of in-hospital mortality. by Poudel et al., CC BY 4.0

PLOS ONE D-dimer as a biomarker for assessment of COVID-19 prognosis: D-dimer levels on admission and its role in predicting disease outcome in hospitalized patients with COVID-19
August 26, 2021 Ayusha Poudel, Yashasa Poudel, Anurag Adhikari, Barun Babu Aryal, Debika Dangol, Tamanna Bajracharya, Anil Maharjan, Rakshya Gautam

Introduction: Coronavirus Disease 2019 is a primarily respiratory illness that can cause thrombotic disorders. Elevation of D-dimer is a…
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Fig 5. LM pathway analysis highlights upregulation of AA-derived LM in non-survivors patients by Palmas et al., CC BY 4.0

PLOS ONE Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients
August 26, 2021 Francesco Palmas, Jennifer Clarke, Romain A. Colas, Esteban A. Gomez, Aoife Keogh, Maria Boylan, Natalie McEvoy, Oliver J. McElvaney, Oisin McElvaney, Razi Alalqam, Noel G. McElvaney, Gerard F. Curley, Jesmond Dalli

Coronavirus disease (COVID)-19, as a result of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has been the direct…
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Calendar by Dafne Cholet CC BY 2.0

PLOS ONE Persisting symptoms three to eight months after non-hospitalized COVID-19, a prospective cohort study
August 26, 2021 Arne Søraas, Karl Trygve Kalleberg, John Arne Dahl, Camilla Lund Søraas, Tor Åge Myklebust, Eyvind Axelsen, Andreas Lind, Roar Bævre-Jensen, Silje Bakken Jørgensen, Mette S. Istre, Eyrun F. Kjetland, Giske Ursin

Long-COVID-19 is a proposed syndrome negatively affecting the health of COVID-19 patients. We present data on self-rated health three to…
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Working place of a coronavirus vaccination center worker by Marco Verch, CC BY 2.0

PLOS ONE Health emergencies and interoceptive sensibility modulate the perception of non-evidence-based drug use: Findings from the COVID-19 outbreak
August 26, 2021 Gerardo Salvato, Daniela Ovadia, Alessandro Messina, Gabriella Bottini

Scientific evidence plays an important role in the therapeutic decision-making process. What happens when physicians are forced to make…
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Hand in medical gloves holding bottle with blue fluid on white background by Jernej Furman, CC BY 2.0

PLOS ONE Don’t close the book on tocilizumab for the treatment of severe COVID-19 pneumonia–the jury is still out: The Kuwait experience
August 24, 2021 Yousef Al-Shamali, Yaser M. Ali, Rawan A. Al-Shamali, Maryam Al-Melahi, Farah R. Al-Shammari, Ahmad Alsaber, Wasl Al-Adsani

Purpose: This cross-sectional observational study aims to report preliminary data from the first experience using tocilizumab for patients…
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Fig 1. VA distribution of the patients by Li et al., CC BY 4.0

PLOS ONE The impact of the COVID-19 pandemic lockdown on rhegmatogenous retinal detachment services—Experiences from the Tongren eye center in Beijing
August 19, 2021 Jipeng Li, Meng Zhao, Haicheng She, Aman Chandra

Purpose: To investigate the impact on services for rhegmatogenous retinal detachment (RRD) patients during the COVID-19 (2019coronal virus…
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Fig 4. Arrhythmogenic Ca2+ release in iPS-CM upon addition of COVID19 serum and treatment with Canakinumab by Dimai et al., CC BY 4.0

PLOS ONE COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab
August 19, 2021 Sanzio Dimai, Lukas Semmler, Ashok Prabhu, Harald Stachelscheid, Judith Huettemeister, Sandra C. Klaucke, Philipp Lacour, Florian Blaschke, Jan Kruse, Abdul Parwani, Leif-Hendrik Boldt, Lars Bullinger, Burkert M. Pieske, Frank R. Heinzel, Felix Hohendanner

Background: Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and…
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Fig 3. The violin/scatter plots depict the concern scores as a function of the Covid Impact for six health categories by Kurzhals et al., CC BY 4.0

PLOS ONE The impact of the Covid-19 pandemic on quality of life in skin cancer patients
August 18, 2021 Jonas K. Kurzhals, Gina Klee, Hauke Busch, Victoria Hagelstein, Detlef Zillikens, Patrick Terheyden, Ewan A. Langan

With more than 82 million cases worldwide and almost two million deaths, the Covid-19 global pandemic shows little sign of abating.…
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Fig 1. Clinical assessments and microbiology by year of admission by Butt et al., CC BY 4.0

PLOS ONE The impact of the COVID-19 pandemic on microbial keratitis presentation patterns
August 18, 2021 Gibran F. Butt, Alberto Recchioni, George Moussa, James Hodson, Graham R. Wallace, Philip I. Murray, Saaeha Rauz

Background: Microbial keratitis (MK) is the most common non-surgical ophthalmic emergency, and can rapidly progress, causing irreversible…
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Fig 1. Relative importance of predictors of cardiovascular involvement by Beck-Friis et al., CC BY 4.0

PLOS ONE No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did not
August 16, 2021 Josefine Beck-Friis, Susannah Leach, Elmir Omerovic, Rickard Zeijlon, Magnus Gisslen, Aylin Yilmaz

Background: Chloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of…
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Medical consultation by nursingschoolsnearme.com, CC BY 2.0

PLOS ONE Obesity is independently associated with septic shock, renal complications, and mortality in a multiracial patient cohort hospitalized with COVID-19
August 12, 2021 Gabrielle Page-Wilson, Rachel Arakawa, Samantha Nemeth, Fletcher Bell, Zachary Girvin, Mary-Claire Tuohy, Max Lauring, Blandine Laferrère, Gissette Reyes-Soffer, Karthik Natarajan, RuiJun Chen, Paul Kurlansky, Judith Korner

Background: Obesity has emerged as a risk factor for severe coronavirus disease 2019 (COVID-19) infection. To inform treatment…
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Fig 1. Geometric map of the emergency department showing the four-tier infection response system by Choi et al., CC BY 4.0

PLOS ONE Efficacy of a four-tier infection response system in the emergency department during the coronavirus disease-2019 outbreak
August 12, 2021 Arom Choi, Ha Yan Kim, Ara Cho, Jiyoung Noh, Incheol Park, Hyun Soo Chung

Introduction: The coronavirus disease (COVID-19) pandemic has delayed the management of other serious medical conditions. This study…
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Doctor chest with stethoscope in pocket by Authority Dental, CC BY 2.0

PLOS ONE Serological prevalence of SARS-CoV-2 infection and associated factors in healthcare workers in a “non-COVID” hospital in Mexico City
August 12, 2021 Esteban Cruz-Arenas, Elizabeth Cabrera-Ruiz, Sara Laguna-Barcenas, Claudia A. Colin-Castro, Tatiana Chavez, Rafael Franco-Cendejas, Clemente Ibarra, Javier Perez-Orive

Background: Mexico is one of the countries with the highest number of deaths from the COVID-19 pandemic. In spite of this high mortality,…
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Fig 1. Mortality rate due to COVID-19 in Brazil and regions in the period from 12ª to 53ª epidemiological week by Costa et al., CC BY 4.0

PLOS ONE Evaluation of the epidemiological behavior of mortality due to COVID-19 in Brazil: A time series study
August 12, 2021 Ketyllem Tayanne da Silva Costa, Thiffany Nayara Bento de Morais, Dayane Caroliny Pereira Justino, Fábia Barbosa de Andrade

The World Health Organization declared, at the end of 2019, a pandemic caused by SARS-CoV-2, a virus that causes Coronavirus…
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Stethoscope, pills, and syringe on white table by Authority Dental, CC BY 2.0

PLOS ONE Changes in the top 25 reasons for primary care visits during the COVID-19 pandemic in a high-COVID region of Canada
August 12, 2021 Ellen Stephenson, Debra A. Butt, Jessica Gronsbell, Catherine Ji, Braden O’Neill, Noah Crampton, Karen Tu

Purpose: We aimed to determine the degree to which reasons for primary care visits changed during the COVID-19 pandemic. Methods: We used…
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Fig 1. Interleukin (IL)-6 levels and severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) RNA copy number in plasma on admission, receiver operating characteristic (ROC) analysis for combined different variables by Saji et al., CC BY 4.0

PLOS ONE Combining IL-6 and SARS-CoV-2 RNAaemia-based risk stratification for fatal outcomes of COVID-19
August 11, 2021 Ryo Saji, Mototsugu Nishii, Kazuya Sakai, Kei Miyakawa, Yutaro Yamaoka, Tatsuma Ban, Takeru Abe, Yutaro Ohyama, Kento Nakajima, Taro Hiromi, Reo Matsumura, Naoya Suzuki, Hayato Taniguchi, Tsuyoshi Otsuka, Yasufumi Oi, Fumihiro Ogawa, Munehito Uchiyama, Kohei Takahashi, Masayuki Iwashita, Yayoi Kimura, Satoshi Fujii, Ryosuke Furuya, Tomohiko Tamura, Akihide Ryo, Ichiro Takeuchi

Background: The coronavirus disease 2019 (COVID-19) pandemic rapidly increases the use of mechanical ventilation (MV). Such cases further…
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Fig 1. Description of the cohort by Shoaib et al., CC BY 4.0

PLOS ONE COVID-19 severity: Studying the clinical and demographic risk factors for adverse outcomes
August 11, 2021 Naila Shoaib, Naila Noureen, Rimsha Munir, Farhad Ali Shah, Noshaba Ishtiaq, Nazia Jamil, Rida Batool, Mohammad Khalid, Ihsan Khan, Naser Iqbal, Nousheen Zaidi

Background: The primary goal of the presented cross-sectional observational study was to determine the clinical and demographic risk…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public Domain

PLOS ONE COVID-19 and cause of pregnancy loss during the pandemic: A systematic review
August 11, 2021 Seyyedeh Neda Kazemi, Bahareh Hajikhani, Hamidreza Didar, Sareh Sadat Hosseini, Sara Haddadi, Farima Khalili, Mehdi Mirsaeidi, Mohammad Javad Nasiri

Introduction: The association between Coronavirus Disease 2019 (COVID-19) and abortion has been debated since the beginning of the COVID-19…
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Intravenous therapy (IV) drip by Robert Geiger, CC BY 2.0

PLOS ONE The tumor patient in the COVID-19 pandemic–an interview-based study of 30 patients undergoing systemic antiproliferative therapy
August 11, 2021 Ulrich Kaiser, Ursula Vehling-Kaiser, Jörg Schmidt, Ana Hoffmann, Florian Kaiser

Introduction: Five months after COVID-19 first occurred and protective regulations were introduced, patients at three outpatient…
PLOS ONE Characteristics and outcomes of acute kidney injury in hospitalized COVID-19 patients: A multicenter study by the Turkish society of nephrology
August 10, 2021 Hakki Arikan, Savas Ozturk, Bulent Tokgoz, Belda Dursun, Nurhan Seyahi, Sinan Trabulus, Mahmud Islam, Yavuz Ayar, Numan Gorgulu, Serhat Karadag, Mahmut Gok, Esra Akcali, Feyza Bora, Zeki Aydın, Eda Altun, Elbis Ahbap, Mehmet Polat, Zeki Soypacacı, Ebru Gok Oguz, Sumeyra Koyuncu, Hulya Colak, İdris Sahin, Murside Esra Dolarslan, Ozant Helvacı, Ilhan Kurultak, Zehra Eren, Hamad Dheir, Melike Betul Ogutmen, Dilek Guven Taymez, Dilek Gibyeli Genek, Sultan Ozkurt, Elif Ari Bakır, Enver Yuksel, Tuncay Sahutoglu, Ozgur Akin Oto, Gulsah Boz, Erkan Sengul, Ekrem Kara, Serhan Tuglular

Background: Acute kidney injury (AKI) is common in coronavirus disease-2019 (COVID-19) and the severity of AKI is linked to adverse…
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Fig 2. Impact of type I IFN-α treatment on SARS-CoV-2-induced weight loss and viral titers by Bessière et al., CC BY 4.0

PLOS Pathogens Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model
August 9, 2021 Pierre Bessière, Marine Wasniewski, Evelyne Picard-Meyer, Alexandre Servat, Thomas Figueroa, Charlotte Foret-Lucas, Amelia Coggon, Sandrine Lesellier, Frank Boué, Nathan Cebron, Blandine Gausserès, Catherine Trumel, Gilles Foucras, Francisco J. Salguero, Elodie Monchatre-Leroy, Romain Volmer

Impaired type I interferons (IFNs) production or signaling have been associated with severe COVID-19, further promoting the evaluation of…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0

PLOS Biology Challenges in interpreting cytokine data in COVID-19 affect patient care and management
August 6, 2021 Stephen Y. Wang, Takehiro Takahashi, Alexander B. Pine, William E. Damsky, Michael Simonov, Yanhua Zhang, Elizabeth Kieras, Christina C. Price, Brett A. King, Mark D. Siegel, Gary V. Desir, Alfred I. Lee, Akiko Iwasaki, Hyung J. Chun

Challenges in using cytokine data are limiting Coronavirus Disease 2019 (COVID-19) patient management and comparison among different…
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Fig 2. ROC analysis of hematological parameters in the diagnosis of severe COVID-19 patients by Kilercik et al., CC BY 4.0

PLOS ONE A new haematocytometric index: Predicting severity and mortality risk value in COVID-19 patients
August 5, 2021 Meltem Kilercik, Özlem Demirelce, Muhittin Abdulkadir Serdar, Parvana Mikailova, Mustafa Serteser

Introduction: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 virus, is a major public health concern spanning from healthy…
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Fig 4. Multivariable logistic regression analysis for 180-day all-cause mortality after hospital admission by Günster et al., CC BY 4.0

PLOS ONE 6-month mortality and readmissions of hospitalized COVID-19 patients: A nationwide cohort study of 8,679 patients in Germany
August 5, 2021 Christian Günster, Reinhard Busse, Melissa Spoden, Tanja Rombey, Gerhard Schillinger, Wolfgang Hoffmann, Steffen Weber-Carstens, Andreas Schuppert, Christian Karagiannidis

Background: COVID-19 frequently necessitates in-patient treatment and in-patient mortality is high. Less is known about the long-term…
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Fig 1. Study design and estimated pregnancy trimester of SARS-CoV-2 infection by Cosma et al. , CC BY 4.0

PLOS ONE Preterm birth is not associated with asymptomatic/mild SARS-CoV-2 infection per se: Pre-pregnancy state is what matters
August 5, 2021 Stefano Cosma, Andrea Roberto Carosso, Jessica Cusato, Fulvio Borella, Marco Carosso, Fiammetta Gervasoni, Ilaria Stura, Mario Preti, Valeria Ghisetti, Giovanni Di Perri, Chiara Benedetto

Evidence for the real impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is unclear, as…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0

PLOS ONE Anxious temperament and cyberchondria as mediated by fear of COVID-19 infection: A cross-sectional study
August 5, 2021 Włodzimierz Oniszczenko

This study’s main goal was to evaluate the association between anxious temperament and the fear of COVID-19-related self-infection and…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0

PLOS Neglected Tropical Diseases Use of minimally invasive autopsy during the COVID-19 pandemic and its possibilities in the context of developing countries
August 4, 2021 Deborah Nunes Melo, Tania Mara Coelho, Giovanna Rolim Pinheiro Lima, Carolina Gomes Fernandes, Bruno Cavalcante Fales de Brito Alves, Fernanda Montenegro de Carvalho Araújo, Renata Aparecida de Almeida Monteiro, Jaume Ordi, Paulo Hilário do Nascimento Saldiva, Luciano Pamplona de Góes Cavalcanti

…
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New Monitor/New Desk by Dave Fayram, CC BY 2.0

PLOS ONE Application of telemedicine in the COVID-19 epidemic: An analysis of Gansu Province in China
August 4, 2021 Yan Wang, Jie Yang, Huijuan Ma, Xinchun Dong, Guangmei Xie, Songning Ye, Juan Du

This paper analyzes the application of various telemedicine services in Gansu Province, China during the COVID-19 epidemic, and summarizes…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain
August 3, 2021 Inés Suárez-García, Isabel Perales-Fraile, Andrés González-García, Arturo Muñoz-Blanco, Luis Manzano, Martín Fabregate, Jesús Díez-Manglano, Eva Fonseca Aizpuru, Francisco Arnalich Fernández, Alejandra García García, Ricardo Gómez-Huelgas, José-Manuel Ramos-Rincón, on behalf of SEMI-COVID-19 Network

Background: Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Examining the potential benefits of the influenza vaccine against SARS-CoV-2: A retrospective cohort analysis of 74,754 patients
August 3, 2021 Susan M. Taghioff, Benjamin R. Slavin, Tripp Holton, Devinder Singh

Introduction: Recently, several single center studies have suggested a protective effect of the influenza vaccine against severe acute…
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Fig 4. Directed acyclic graph describing relationships between the COVID-19 pandemic and a reduction in COPD exacerbations by Alqahtani et al., CC BY 4.0

PLOS ONE Reduction in hospitalised COPD exacerbations during COVID-19: A systematic review and meta-analysis
August 3, 2021 Jaber S. Alqahtani, Tope Oyelade, Abdulelah M. Aldhahir, Renata Gonçalves Mendes, Saeed M. Alghamdi, Marc Miravitlles, Swapna Mandal, John R. Hurst

Background: Reports have suggested a reduction in exacerbations of chronic obstructive pulmonary disease (COPD) during the coronavirus…
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Fig 2. Hospitalized COVID-19 patients in Houston Trauma Service Area (TSA-Q) and Houston Methodist Hospital System over time by Sandoval et al., CC BY 4.0

PLOS ONE Risk factors for severity of COVID-19 in hospital patients age 18–29 years
July 30, 2021 Micaela Sandoval, Duc T. Nguyen, Farhaan S. Vahidy, Edward A. Graviss

Background: Since February 2020, over 2.5 million Texans have been diagnosed with COVID-19, and 20% are young adults at risk for SARS-CoV-2…
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Image title by agilemktg1, Public Domain Mark 1.0

PLOS ONE Trends in COVID-19 cases and clinical management in Veterans Health Administration medical facilities: A national cohort study
July 29, 2021 Maya Aboumrad, Brian Shiner, Natalie Riblet, Hugh Huizenga, Nabin Neupane, Yinong Young-Xu

Objective: We explored longitudinal trends in sociodemographic characteristics, reported symptoms, laboratory findings, pharmacological and…
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Fig 1. Timeline of the study by Arévalos et al., CC BY 4.0

PLOS ONE Long-term effects of coronavirus disease 2019 on the cardiovascular system, CV COVID registry: A structured summary of a study protocol
July 29, 2021 Victor Arévalos, Luis Ortega-Paz, Diego Fernandez-Rodríguez, Víctor Alfonso Jiménez-Díaz, Jordi Bañeras Rius, Gianluca Campo, Miguel Rodríguez-Santamarta, Armando Pérez de Prado, Antonio Gómez-Menchero, José Francisco Díaz Fernández, Claudia Scardino, Nieves Gonzalo, Alberto Pernigotti, Fernando Alfonso, Ignacio Jesús Amat-Santos, Antonio Silvestro, Alfonso Ielasi, José María de la Torre, Gabriela Bastidas, Josep Gómez-Lara, Manel Sabaté, Salvatore Brugaletta, on behalf of the CV COVID-19 Registry Investigators

Background: Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events,…
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Fig 2 by Wilde et al., CC BY 4.0

PLOS ONE A national retrospective study of the association between serious operational problems and COVID-19 specific intensive care mortality risk
July 29, 2021 Harrison Wilde, John M. Dennis, Andrew P. McGovern, Sebastian J. Vollmer, Bilal A. Mateen

Objectives: To describe the relationship between reported serious operational problems (SOPs), and mortality for patients with COVID-19…
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Fig 4. Schematic illustration of SARS-CoV-2 infection and the role of HIF − 1α on SARS-CoV-2 pathogenesis by Habibi et al., CC BY 4.0

PLOS ONE Topological network based drug repurposing for coronavirus 2019
July 29, 2021 Mahnaz Habibi, Golnaz Taheri

The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has become the current health concern and…
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Fig 1. Pre-pandemic versus pandemic hospital LOS from POD 0–10 for craniotomy and endonasal cohorts by Mallari et al., CC BY 4.0

PLOS ONE Streamlining brain tumor surgery care during the COVID-19 pandemic: A case-control study
July 29, 2021 Regin Jay Mallari, Michael B. Avery, Alex Corlin, Amalia Eisenberg, Terese C. Hammond, Neil A. Martin, Garni Barkhoudarian, Daniel F. Kelly

Background: The COVID-19 pandemic forced a reconsideration of surgical patient management in the setting of scarce resources and risk of…
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Fig 2. Survival curves adjusted for active leprosy and COVID-19 positive household contact representing possible risk factors for the occurrence of COVID-19. by Vinicius et al., CC BY 4.0

PLOS Neglected Tropical Diseases The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study
July 28, 2021 Selma Regina Penha Silva Cerqueira, Patrícia Duarte Deps, Débora Vilela Cunha, Natanael Victor Furtunato Bezerra, Daniel Holanda Barroso, Ana Bárbara Sapienza Pinheiro, Gecilmara Salviato Pillegi, Taynah Alves Rocha Repsold, Patrícia Shu Kurizky, Simon M. Collin, Ciro Martins Gomes

Background: Protective effects of Bacillus Calmette–Guérin (BCG) vaccination and clofazimine and dapsone treatment against severe acute…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0

PLOS ONE High mortality among kidney transplant recipients diagnosed with coronavirus disease 2019: Results from the Brazilian multicenter cohort study
July 28, 2021 Lúcio R. Requião-Moura, Tainá Veras de Sandes-Freitas, Laila Almeida Viana, Marina Pontello Cristelli, Luis Gustavo Modelli de Andrade, Valter Duro Garcia, Claudia Maria Costa de Oliveira, Ronaldo de Matos Esmeraldo, Mario Abbud Filho, Alvaro Pacheco-Silva, Katia Cronemberger Sousa, Alessandra Rosa Vicari, Kellen Micheline Alves Henrique Costa, Denise Rodrigues Simão, Marcos Vinicius de Sousa, Juliana Bastos Campos, Ricardo Augusto Monteiro de Barros Almeida, Luciane Mônica Deboni, Miguel Moysés Neto, Juliana Aparecida Zanocco, Helio Tedesco-Silva, José Medina-Pestana, on behalf of COVID-19-KT Brazil

Background: Kidney transplant (KT) recipients are considered a high-risk group for unfavorable outcomes in the course of coronavirus…
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Fig 3 by Briggs et al., CC BY 4.0

PLOS ONE Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19
July 28, 2021 Neima Briggs, Michael V. Gormally, Fangyong Li, Sabrina L. Browning, Miriam M. Treggiari, Alyssa Morrison, Maudry Laurent-Rolle, Yanhong Deng, Jeanne E. Hendrickson, Christopher A. Tormey, Mahalia S. Desruisseaux

Background: Limited therapeutic options exist for coronavirus disease 2019 (COVID-19). COVID-19 convalescent plasma (CCP) is a potential…
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3D-printed physical model of SARS-CoV-2 by NIH, Public Domain 1.0

PLOS ONE Lower serum 25(OH)D levels associated with higher risk of COVID-19 infection in U.S. Black women
July 27, 2021 Yvette C. Cozier, Nelsy Castro-Webb, Natasha S. Hochberg, Lynn Rosenberg, Michelle A. Albert, Julie R. Palmer

Objective: Limited evidence suggests that higher levels of serum vitamin D (25(OH)D) protect against SARS-CoV-2 virus (COVID-19) infection.…
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Fig 4. Cumulative frequency of observed sedation depth by Flinspach et al., CC BY 4.0

PLOS ONE High sedation needs of critically ill COVID-19 ARDS patients—A monocentric observational study
July 27, 2021 Armin Niklas Flinspach, Hendrik Booke, Kai Zacharowski, Ümniye Balaban, Eva Herrmann, Elisabeth Hannah Adam

Background: Therapy of severely affected coronavirus patient, requiring intubation and sedation is still challenging. Recently,…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, Public Domain Mark 1.0

PLOS ONE COVID-19 severity and mortality in multiple sclerosis are not associated with immunotherapy: Insights from a nation-wide Austrian registry
July 27, 2021 Gabriel Bsteh, Hamid Assar, Harald Hegen, Bettina Heschl, Fritz Leutmezer, Franziska Di Pauli, Christiane Gradl, Gerhard Traxler, Gudrun Zulehner, Paulus Rommer, Peter Wipfler, Michael Guger, Christian Enzinger, Thomas Berger, for the AUT-MuSC investigators

Background: The COVID-19 pandemic challenges neurologists in counselling patients with multiple sclerosis (pwMS) regarding their risk by…
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Fig 2. Receiver operating characteristic (ROC) curve is showing the relative diagnostic performances of creatinine, CRP, D-dimer, ferritin, neutrophils, and SGPTA by Rahman et al., CC BY 4.0

PLOS ONE Hematological abnormalities and comorbidities are associated with COVID-19 severity among hospitalized patients: Experience from Bangladesh
July 27, 2021 Md. Ashrafur Rahman, Yeasna Shanjana, Md. Ismail Tushar, Tarif Mahmud, Ghazi Muhammad Sayedur Rahman, Zahid Hossain Milan, Tamanna Sultana, Ali Mohammed Lutful Hoq Chowdhury, Mohiuddin Ahmed Bhuiyan, Md. Rabiul Islam, Hasan Mahmud Reza

Background: The hematological abnormalities are assumed to be involved in the disease progression of COVID-19. However, the actual…
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Fig 1. Brazil political-geographic map showing its federative units (states), and the location of the participating centers of REBRACO by Costa et al., CC BY 4.0

PLOS ONE Facing the COVID-19 pandemic inside maternities in Brazil: A mixed-method study within the REBRACO initiative
July 23, 2021 Maria Laura Costa, Renato T. Souza, Rodolfo C. Pacagnella, Silvana F. Bento, Carolina C. Ribeiro-do-Valle, Adriana G. Luz, Giuliane J. Lajos, Guilherme M. Nobrega, Thayna B. Griggio, Charles M. Charles, Ricardo P. Tedesco, Karayna G. Fernandes, Sérgio H. A. Martins-Costa, Frederico J. A. Peret, Francisco E. Feitosa, Rosiane Mattar, Edson V. Cunha Filho, Janete Vetorazzi, Samira M. Haddad, Carla B. Andreucci, José P. Guida, Mário D. Correa Junior, Marcos A. B. Dias, Leandro G. Oliveira, Elias F. Melo Junior, Carlos A. S. Menezes, Marília G. Q. Luz, Jose G. Cecatti, for the REBRACO Study Group

Introduction: COVID-19 pandemic posed major challenges in obstetric health care services. Preparedness, development, and implementation of…
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Fig 1. Bayesian reanalysis of clinical trials testing the efficacy of remdesivir against COVID-19 by Hoek et al., CC BY 4.0

PLOS ONE Rethinking remdesivir for COVID-19: A Bayesian reanalysis of trial findings
July 23, 2021 Joyce M. Hoek, Sarahanne M. Field, Ymkje Anna de Vries, Maximilian Linde, Merle-Marie Pittelkow, Jasmine Muradchanian, Don van Ravenzwaaij

Background: Following testing in clinical trials, the use of remdesivir for treatment of COVID-19 has been authorized for use in parts of…
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Fig 1. Experimental model simulating endoscopic examination by Keil et al., CC BY 4.0

PLOS ONE Commonly available but highly effective protection against SARS-CoV-2 during gastrointestinal endoscopies
July 23, 2021 Radan Keil, Štěpán Hlava, Petr Stanovský, Vladimír Ždímal, Jan Šťovíček, Milan Trojánek, Jiří Drábek, Barbora Frýbová, Vojtěch Petráček, Martin Wasserbauer

Background and aims: SARS-CoV-2 is a worldwide serious health problem. The aim of this study was to demonstrate the number of potentially…
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Fig 1. Clinical features of the cohort by Meis-Pinheiro et al., CC BY 4.0

PLOS ONE Clinical characteristics of COVID-19 in older adults. A retrospective study in long-term nursing homes in Catalonia
July 23, 2021 Uxío Meis-Pinheiro, Francesc Lopez-Segui, Sandra Walsh, Anton Ussi, Sebastia Santaeugenia, Jose Augusto Garcia-Navarro, Antonio San-Jose, Antoni L. Andreu, Magda Campins, Benito Almirante

The natural history of COVID-19 and predictors of mortality in older adults need to be investigated to inform clinical operations and…
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Fig 3. Laboratory tests of dialysis patients with COVID19 with comparison of baseline and day 7 (for lymphocyte and Albumin levels) and baseline and peak value (for WBC, ferritin, CRP and IL-6) by Ghonimi et al., CC BY 4.0

PLOS ONE Mortality and associated risk factors of COVID-19 infection in dialysis patients in Qatar: A nationwide cohort study
July 22, 2021 Tarek Abdel Latif Ghonimi, Mohamad Mahmood Alkad, Essa Abdulla Abuhelaiqa, Muftah M. Othman, Musab Ahmed Elgaali, Rania Abdelaziz M. Ibrahim, Shajahan M. Joseph, Hassan Ali Al-Malki, Abdullah Ibrahim Hamad

Context: Patients on maintenance dialysis are more susceptible to COVID-19 and its severe form. We studied the mortality and associated…
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Fig 2. Frequency of severe COVID-19 (death/ICU/ hospitalization ≥10 days) by pre-infection fasting blood glucose, among patients with (in black) and without (in grey) a diagnosis of diabetes by Shauly-Aharonov et al., CC BY 4.0

PLOS ONE Both high and low pre-infection glucose levels associated with increased risk for severe COVID-19: New insights from a population-based study
July 22, 2021 Michal Shauly-Aharonov, Asher Shafrir, Ora Paltiel, Ronit Calderon-Margalit, Rifaat Safadi, Roee Bicher, Orit Barenholz-Goultschin, Joshua Stokar

Importance: Patients with diabetes are known to be at increased risk for infections including severe coronavirus disease 2019 (COVID-19)…
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Image title by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0

PLOS ONE The impact of medical teleconsultations on general practitioner-patient communication during COVID- 19: A case study from Poland
July 16, 2021 Magdalena Kludacz-Alessandri, Liliana Hawrysz, Piotr Korneta, Grażyna Gierszewska, Wioletta Pomaranik, Renata Walczak

According to the outbreak of the Covid-19 pandemic, medical teleconsultations using various technologies have become an important tool to…
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Fig 1. Source of information about COVID-19 among the outpatient service visitors at Debre Markos compressive specialized hospital, Amhara regional state, Ethiopia, 2020 by Feleke et al., CC BY 4.0

PLOS ONE Knowledge, attitude and preventive practice towards COVID-19 and associated factors among outpatient service visitors at Debre Markos compressive specialized hospital, north-west Ethiopia, 2020
July 15, 2021 Bekele Taye Feleke, Mengistu Zelalem Wale, Mesenbet Terefe Yirsaw

Background: COVID-19 is an emerging infectious disease which is a major public health problem worldwide. Given the serious threats imposed…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, Public Domain Mark 1.0

PLOS ONE Manifestations of renal system involvement in hospitalized patients with COVID-19 in Saudi Arabia
July 15, 2021 Khaled S. Allemailem, Ahmad Almatroudi, Amjad Ali Khan, Arshad H. Rahmani, Ibrahim S. Almarshad, Fahad S. Alekezem, Nagwa Hassanein, Asmaa M. El-Kady

Background: Although COVID-19 is an acute disease that usually resolves rapidly in most cases, the disease can be fatal and has a mortality…
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Image title by NIAID/NIH, Public Domain Mark 1.0

PLOS ONE Relation of prior statin and anti-hypertensive use to severity of disease among patients hospitalized with COVID-19: Findings from the American Heart Association’s COVID-19 Cardiovascular Disease Registry
July 15, 2021 Lori B. Daniels, Junting Ren, Kris Kumar, Quan M. Bui, Jing Zhang, Xinlian Zhang, Mariem A. Sawan, Howard Eisen, Christopher A. Longhurst, Karen Messer

Background: Statins have anti-inflammatory and immunomodulatory effects that may reduce the severity of coronavirus disease 2019…
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Fig 2. The proportion of municipalities attended by TRS in Brazil by region by Montelongo et al., CC BY 4.0

PLOS ONE The management of COVID-19 cases through telemedicine in Brazil
July 14, 2021 Alfredo Montelongo, João Luiz Becker, Rudi Roman, Elise Botteselle de Oliveira, Roberto Nunes Umpierre, Marcelo Rodrigues Gonçalves, Rodolfo Silva, Katarzyna Doniec, Ali K. Yetisen

In Dec 2020 Brazil became one of the worldwide epicenters of the COVID-19 pandemic with more than 7.2M reported cases. Brazil has a large…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain 1.0

PLOS ONE Pre-hospital causes for delayed arrival in acute ischemic stroke before and during the COVID-19 pandemic: A study at two stroke centers in Egypt
July 14, 2021 Hany M. Aref, Hossam Shokri, Tamer M. Roushdy, Fatma Fathalla, Nevine M. El Nahas

Background: In the current study we investigated the causes of pre-hospital delay as this can compromise the patient’s chance to receive…
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Fig 1. Immune response to SARS-CoV-2 infection model schematic by Jenner et al., CC BY 4.0

PLOS Pathogens COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes
July 14, 2021 Adrianne L. Jenner, Rosemary A. Aogo, Sofia Alfonso, Vivienne Crowe, Xiaoyan Deng, Amanda P. Smith, Penelope A. Morel, Courtney L. Davis, Amber M. Smith, Morgan Craig

To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we…
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bacteria/viruses by John Voo, CC BY 2.0

PLOS ONE Bacterial superinfection in adults with COVID-19 hospitalized in two clinics in Medellín-Colombia, 2020
July 13, 2021 Juan Carlos Cataño-Correa, Jaiberth Antonio Cardona-Arias, Jessica Paola Porras Mancilla, Marcela Tabares García

COVID-19 represents high morbidity and mortality, its complications and lethality have increased due to bacterial superinfections. We…
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Fig 2. Outcome of the patients in each group by Miki et al., CC BY 4.0

PLOS ONE On-admission SARS-CoV-2 RNAemia as a single potent predictive marker of critical condition development and mortality in COVID-19
July 13, 2021 Shoji Miki, Hiroaki Sasaki, Hiroshi Horiuchi, Nobuyuki Miyata, Yukihiro Yoshimura, Kazuhito Miyazaki, Takayuki Matsumura, Yoshimasa Takahashi, Tadaki Suzuki, Tetsuro Matano, Ai Kawana-Tachikawa, Natsuo Tachikawa

Background: This study aimed to clarify how SARS-CoV-2 RNAemia is related to COVID-19 critical condition development and mortality in…
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Jefferson City Medical Group could help with shortage of flu shots by KOMUnews, CC BY 2.0

PLOS ONE Intention to receive vaccine against COVID-19 and associated factors among health professionals working at public hospitals in resource limited settings
July 12, 2021 Mohammedjud Hassen Ahmed, Shuma Gosha Kanfe, Mohammedamin Hajure Jarso

Backgrounds: Health professionals are among the frontline of COVID-19 pandemic exposure and identified as a priority target group that need…
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Inauguración del Hospital Municipal de Chiconcuac by Presidencia de la República Mexicana, CC BY 2.0

PLOS ONE Burden of post-COVID-19 syndrome and implications for healthcare service planning: A population-based cohort study
July 12, 2021 Dominik Menges, Tala Ballouz, Alexia Anagnostopoulos, Hélène E. Aschmann, Anja Domenghino, Jan S. Fehr, Milo A. Puhan

Background: Longer-term consequences after SARS-CoV-2 infection are becoming an important burden to societies and healthcare systems. Data…
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Fig 1. Subgroup breakdown for analyses. by Brojakowska et al., CC BY 4.0

PLOS ONE Comorbidities, sequelae, blood biomarkers and their associated clinical outcomes in the Mount Sinai Health System COVID-19 patients
July 6, 2021 Agnieszka Brojakowska, Abrisham Eskandari, Malik Bisserier, Jeffrey Bander, Venkata Naga Srikanth Garikipati, Lahouaria Hadri, David A. Goukassian, Kenneth M. Fish

With the continuing rise of SARS-CoV2 infection globally and the emergence of various waves in different countries, understanding…
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Fig 1. Weekly incidence and 95% confidence intervals of elective surgeries in 2020 and in the reference years. by Uimonen et al., CC BY 4.0

PLOS ONE The impact of the COVID-19 pandemic on waiting times for elective surgery patients: A multicenter study
July 6, 2021 Mikko Uimonen, Ilari Kuitunen, Juha Paloneva, Antti P. Launonen, Ville Ponkilainen, Ville M. Mattila

Background: A concern has been that health care reorganizations during the first COVID-19 wave have led to delays in elective surgeries,…
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Fig 3. Clinical parameters during the 7-day study period. by Kim et al., CC BY 4.0

PLOS ONE Dexamethasone may improve severe COVID-19 via ameliorating endothelial injury and inflammation: A preliminary pilot study
July 2, 2021 Won-Young Kim, Oh Joo Kweon, Min Jae Cha, Moon Seong Baek, Seong-Ho Choi

Dexamethasone provides benefits in patients with coronavirus disease 2019 (COVID-19), although data regarding immunological profiles and…
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Fig 3. Impact of COVID-19 on nursing care processes and care delivery. by Anton et al., CC BY 4.0

PLOS ONE Identifying factors that nurses consider in the decision-making process related to patient care during the COVID-19 pandemic
July 2, 2021 Nicholas Anton, Tera Hornbeck, Susan Modlin, Md Munirul Haque, Megan Crites, Denny Yu

Background: Nurse identification of patient deterioration is critical, particularly during the COVID-19 pandemic, as patients can…
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Fig 1. S1 IgM titres in COVID-19 patients (recovered and deceased) and asymptomatic subjects. by Marchi et al., CC BY 4.0

PLOS ONE Characterization of antibody response in asymptomatic and symptomatic SARS-CoV-2 infection
July 2, 2021 Serena Marchi, Simonetta Viviani, Edmond J. Remarque, Antonella Ruello, Emilio Bombardieri, Valentina Bollati, Gregorio P. Milani, Alessandro Manenti, Giulia Lapini, Annunziata Rebuffat, Emanuele Montomoli, Claudia M. Trombetta

SARS-CoV-2 pandemic is causing high morbidity and mortality burden worldwide with unprecedented strain on health care systems. To…
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Fig 1. Illustration of the modeling framework. by Mahdavi et al., CC BY 4.0

PLOS ONE A machine learning based exploration of COVID-19 mortality risk
July 2, 2021 Mahdi Mahdavi, Hadi Choubdar, Erfan Zabeh, Michael Rieder, Safieddin Safavi-Naeini, Zsolt Jobbagy, Amirata Ghorbani, Atefeh Abedini, Arda Kiani, Vida Khanlarzadeh, Reza Lashgari, Ehsan Kamrani

Early prediction of patient mortality risks during a pandemic can decrease mortality by assuring efficient resource allocation and…
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Fig 2. Relationship between new COVID-19 cases per 100,000 (cumulative rate per month) and national sales volumes of antibiotics, azithromycin, doxycycline, faropenem, and HCQ from January to December 2020. by Sulis et al., CC BY 4.0

PLOS Medicine Sales of antibiotics and hydroxychloroquine in India during the COVID-19 epidemic: An interrupted time series analysis
July 1, 2021 Giorgia Sulis, Brice Batomen, Anita Kotwani, Madhukar Pai, Sumanth Gandra

Background: We assessed the impact of the coronavirus disease 2019 (COVID-19) epidemic in India on the consumption of antibiotics and…
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Fig 6. by Seeßle et al., CC BY 4.0

PLOS ONE High rate of HSV-1 reactivation in invasively ventilated COVID-19 patients: Immunological findings
July 1, 2021 Jessica Seeßle, Theresa Hippchen, Paul Schnitzler, Julia Gsenger, Thomas Giese, Uta Merle

SARS-CoV-2 infection can lead to severe acute respiratory distress syndrome with the need of invasive ventilation. Pulmonary herpes…
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Fig 1. by Tsukanov et al., CC BY 4.0

PLOS ONE How risky is it to visit a supermarket during the pandemic?
July 1, 2021 Alexey A. Tsukanov, Alexandra M. Senjkevich, Maxim V. Fedorov, Nikolai V. Brilliantov

We performed large-scale numerical simulations using a composite model to investigate the infection spread in a supermarket during a…
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Fig 1. Reported indications for use of TCIM during COVID-19. by Lam et al., CC BY 4.0

PLOS ONE A public survey of traditional, complementary and integrative medicine use during the COVID-19 outbreak in Hong Kong
July 1, 2021 Chun Sing Lam, Ho Kee Koon, Vincent Chi-Ho Chung, Yin Ting Cheung

Background: During COVID-19, the public actively sought non-pharmacological and self-management approaches to prevent infection. Little is…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE The impact of the SARS-COV2 infection on the disorder of consciousness rehabilitation unit
June 30, 2021 Silvia Marino, Rosella Ciurleo, Antonino Todaro, Antonella Alagna, Anna Lisa Logiudice, Francesco Corallo, Caterina Formica, Carmela Rifici, Patrizia Pollicino, Fabrizia Caminiti, Elisabetta Morini, Placido Bramanti

Background and objective: Disorders of consciousness include coma (cannot be aroused, eye remain closed), vegetative state—VS (can appear…
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Fig 2. Comparison of unadjusted trends in psychiatry consults between 2019 and 2020 cohorts. by McDowell et al., CC BY 4.0

PLOS ONE Evaluating the association between COVID-19 and psychiatric presentations, suicidal ideation in an emergency department
June 30, 2021 Michal J. McDowell, Carrie E. Fry, Mladen Nisavic, Mila Grossman, Charles Masaki, Emily Sorg, Suzanne Bird, Felicia Smith, Scott R. Beach

Objective: To estimate the association between COVID-19 and Emergency Department (ED) psychiatric presentations, including suicidal…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis
June 29, 2021 Ana Karla G. Melo, Keilla M. Milby, Ana Luiza M. A. Caparroz, Ana Carolina P. N. Pinto, Rodolfo R. P. Santos, Aline P. Rocha, Gilda A. Ferreira, Viviane A. Souza, Lilian D. A. Valadares, Rejane M. R. A. Vieira, Gecilmara S. Pileggi, Virgínia F. M. Trevisani

Objective: To describe the laboratory parameters and biomarkers of the cytokine storm syndrome associated with severe and fatal COVID-19…
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Fig 1. Timeline of the laboratory preparedness and response in the Americas Region to the COVID-19 outbreak, 31 December 2019 to 24 February 2020. by Leite et al., CC BY 4.0

PLOS ONE COVID-19 laboratory preparedness and response in the Americas Region: Lessons learned
June 29, 2021 Juliana Almeida Leite, Lionel Gresh, Andrea Vicari, Jean Marc Gabastou, Enrique Perez, Sylvain Aldighieri, SARINET laboratories Network , Jairo Mendez-Rico

By the time the etiologic agent of the COVID-19 was identified as a novel coronavirus, no country in the Americas Region had laboratory…
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Fig 1. Distribution of the SARS-CoV-2 antibody S/CO index measured by three chemiluminescence immunoassays according to days after onset. by Lee et al., CC BY 4.0

PLOS ONE Comparison of three serological chemiluminescence immunoassays for SARS-CoV-2, and clinical significance of antibody index with disease severity
June 29, 2021 Nuri Lee, Seri Jeong, Min-Jeong Park, Wonkeun Song

Background: The clinical significance of the quantitative value of antibodies in severe acute respiratory syndrome coronavirus 2…
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Fig 2. Primary study overlap matrix (percentage) across included systematic reviews*. by Ciapponi et al., CC BY 4.0

PLOS ONE COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes
June 29, 2021 Agustín Ciapponi, Ariel Bardach, Daniel Comandé, Mabel Berrueta, Fernando J. Argento, Federico Rodriguez Cairoli, Natalia Zamora, Victoria Santa María, Xu Xiong, Sabra Zaraa, Agustina Mazzoni, Pierre Buekens

Background: We conducted an overview of systematic reviews (SRs) summarizing the best evidence regarding the effect of COVID-19 on maternal…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and eosinophils correlation with high-resolution computer tomography severity score in COVID-19 patients
June 28, 2021 Milena Adina Man, Ruxandra-Mioara Rajnoveanu, Nicoleta Stefania Motoc, Cosmina Ioana Bondor, Ana Florica Chis, Andrei Lesan, Ruxandra Puiu, Sergiu-Remus Lucaciu, Elena Dantes, Bianca Gergely-Domokos, Ovidiu Fira-Mladinescu

Inflammation has an important role in the progression of various viral pneumonia, including COVID-19. Circulating biomarkers that can…
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Fig 1. Pattern of worry scores of COVID-19 crisis by hospital. by Deressa et al., CC BY 4.0

PLOS ONE Risk perceptions and preventive practices of COVID-19 among healthcare professionals in public hospitals in Addis Ababa, Ethiopia
June 25, 2021 Wakgari Deressa, Alemayehu Worku, Workeabeba Abebe, Muluken Gizaw, Wondwossen Amogne

Healthcare professionals are at higher risk of contracting the new coronavirus disease 2019 (COVID-19). Although appropriate preventive…
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Novel Coronavirus SARS-CoV-2 by NIAID, CC-0 Public Domain

PLOS ONE Impact of Covid-19 on attendances for a 1^st episode of reduced fetal movements: A retrospective observational study
June 25, 2021 Laia Marques-Fernandez, Swati Sharma, Una Mannu, Hsu Phern Chong

Background: Prior studies have demonstrated an increased stillbirth rate. It was suggested that the COVID-19 pandemic may have impacted on…
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Fig 1. Mortality rates over time in adults with COVID-19 and acute respiratory distress syndrome or acute respiratory failure. by Yeates et al., CC BY 4.0

PLOS ONE Improved outcomes over time for adult COVID-19 patients with acute respiratory distress syndrome or acute respiratory failure
June 25, 2021 Eric O. Yeates, Jeffry Nahmias, Justine Chinn, Brittany Sullivan, Stephen Stopenski, Alpesh N. Amin, Ninh T. Nguyen

Background: COVID-19’s pulmonary manifestations are broad, ranging from pneumonia with no supplemental oxygen requirements to acute…
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Fig 1. by Deol et al., CC BY 4.0

PLOS ONE Estimating ventilation rates in rooms with varying occupancy levels: Relevance for reducing transmission risk of airborne pathogens
June 24, 2021 Arminder K. Deol, Danny Scarponi, Peter Beckwith, Tom A. Yates, Aaron S. Karat, Ada W. C. Yan, Kathy S. Baisley, Alison D. Grant, Richard G. White, Nicky McCreesh

Background: In light of the role that airborne transmission plays in the spread of SARS-CoV-2, as well as the ongoing high global mortality…
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Syringe and Vaccine by NIH/NIAID, CC BY 2.0

PLOS ONE Determinant of intention to receive COVID-19 vaccine among school teachers in Gondar City, Northwest Ethiopia
June 24, 2021 Simegnew Handebo, Maereg Wolde, Kegnie Shitu, Ayenew Kassie

Background: Scientists across the world are working on innovating a successful vaccine that will save lives and end COVID-19 pandemic.…
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Fig 3. Statin use, after hospitalization. by Chow et al., CC BY 4.0

PLOS ONE The protective association between statins use and adverse outcomes among COVID-19 patients: A systematic review and meta-analysis
June 24, 2021 Ronald Chow, James Im, Nicholas Chiu, Leonard Chiu, Rahul Aggarwal, Jihui Lee, Young-Geun Choi, Elizabeth Horn Prsic, Hyun Joon Shin

Introduction: Statins may reduce a cytokine storm, which has been hypothesized as a possible mechanism of severe COVID-19 pneumonia. The…
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Fig 1. Histogram of intervals between estimated origin dates and first cases (Origin) and between upper bounds of 95% confidence intervals and first cases (95% CI). by Roberts et al., CC BY 4.0

PLOS Pathogens Dating first cases of COVID-19
June 24, 2021 David L. Roberts, Jeremy S. Rossman, Ivan Jarić

Questions persist as to the origin of the COVID-19 pandemic. Evidence is building that its origin as a zoonotic spillover occurred prior…
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Fig 1. Correlation heatmap between self-defined ethnicities and pre-existing conditions. by Cavallaro et al., CC BY 4.0

PLOS Computational Biology Contrasting factors associated with COVID-19-related ICU admission and death outcomes in hospitalised patients by means of Shapley values
June 23, 2021 Massimo Cavallaro, Haseeb Moiz, Matt J. Keeling, Noel D. McCarthy

Identification of those at greatest risk of death due to the substantial threat of COVID-19 can benefit from novel approaches to…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE COVID-19 pneumonia in Galicia (Spain): Impact of prognostic factors and therapies on mortality and need for mechanical ventilation
June 23, 2021 Luis Pérez-de-Llano, Eva María Romay-Lema, Adolfo Baloira-Villar, Christian Anchorena, María Luisa Torres-Durán, Adrián Sousa, Dolores Corbacho-Abelaira, José Paz-Ferrin, Carmen Diego-Roza, Laura Vilariño-Maneiro, Pedro J. Marcos, Carmen Montero-Martínez, Fernando de la Iglesia-Martínez, Vanessa Riveiro-Blanco, Nuria Rodríguez-Núñez, José Abal-Arca, María Bustillo-Casado, Rafael Golpe

Introduction: This study was aimed to identify risk factors associated with unfavorable outcomes (composite outcome variable: mortality and…
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Fig 2. Map of national seroprevalence studies reporting population-wide estimates. by Natural Earth and Bobrovitz et al., CC BY 4.0

PLOS ONE Global seroprevalence of SARS-CoV-2 antibodies: A systematic review and meta-analysis
June 23, 2021 Niklas Bobrovitz, Rahul Krishan Arora, Christian Cao, Emily Boucher, Michael Liu, Claire Donnici, Mercedes Yanes-Lane, Mairead Whelan, Sara Perlman-Arrow, Judy Chen, Hannah Rahim, Natasha Ilincic, Mitchell Segal, Nathan Duarte, Jordan Van Wyk, Tingting Yan, Austin Atmaja, Simona Rocco, Abel Joseph, Lucas Penny, David A. Clifton, Tyler Williamson, Cedric P. Yansouni, Timothy Grant Evans, Jonathan Chevrier, Jesse Papenburg, Matthew P. Cheng

Background: Many studies report the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. We aimed to…
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Fig 1. Odds ratios for critical and fatal illness according to body mass index. by Kang and Kong, CC BY 4.0

PLOS ONE Body mass index and severity/fatality from coronavirus disease 2019: A nationwide epidemiological study in Korea
June 22, 2021 In Sook Kang, Kyoung Ae Kong

Objective: Obesity has been reported as a risk factor for severe coronavirus disease 2019 (COVID-19) in recent studies. However, the…
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Novel Coronavirus SARS-Cov-2 by NIAID, CC-0 Public Domain

PLOS ONE Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia
June 21, 2021 Shambel Araya, Mintesnot Aragaw Mamo, Yakob Gebregziabher Tsegay, Asegdew Atlaw, Aschalew Aytenew, Abebe Hordofa, Abebe Edao Negeso, Moges Wordofa, Tirhas Niguse, Mahlet Cheru, Zemenu Tamir

Background: Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal…
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Fig 1. Logistic growth curve of the COVID-19 pandemic. by Kaimann and Tanneberg, CC BY 4.0

PLOS ONE What containment strategy leads us through the pandemic crisis? An empirical analysis of the measures against the COVID-19 pandemic
June 21, 2021 Daniel Kaimann, Ilka Tanneberg

Since January 2020, the COVID-19 outbreak has been progressing at a rapid pace. To keep the pandemic at bay, countries have implemented…
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3D-printed physical model of SARS-CoV-2 by NIH, CC-0 Public Domain

PLOS ONE Predictors of severity and mortality among patients hospitalized with COVID-19 in Rhode Island
June 18, 2021 Aakriti Pandita, Fizza S. Gillani, Yiyun Shi, Anna Hardesty, Meghan McCarthy, Jad Aridi, Dimitrios Farmakiotis, Silvia S. Chiang, Curt G. Beckwith

Background: In order for healthcare systems to prepare for future waves of COVID-19, an in-depth understanding of clinical predictors is…
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Fig 2. The position of the simulation box, native ligand, and cluster of spheres relative to the receptor. by Purwati et al., CC BY 4.0

PLOS ONE An in vitro study of dual drug combinations of anti-viral agents, antibiotics, and/or hydroxychloroquine against the SARS-CoV-2 virus isolated from hospitalized patients in Surabaya, Indonesia
June 18, 2021 Purwati, Andang Miatmoko, Nasronudin, Eryk Hendrianto, Deya Karsari, Aristika Dinaryanti, Nora Ertanti, Igo Syaiful Ihsan, Disca Sandyakala Purnama, Tri Pudy Asmarawati, Erika Marfiani, Yulistiani, Alfian Nur Rosyid, Prastuti Asta Wulaningrum, Herley Windo Setiawan, Imam Siswanto, Ni Nyoman Tri Puspaningsih

A potent therapy for the infectious coronavirus disease COVID-19 is urgently required with, at the time of writing, research in this area…
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Fig 3. Scatterplot of the incidence rate of tuberculosis (TB) in 1990 versus (a) the cumulative mortality rate of COVID-19 and (b) the cumulative incidence rate of COVID-19 on 5 April 2020 according to BCG vaccination status among 90 countries. by Inoue and Kashima, CC BY 4.0

PLOS ONE Association of the past epidemic of Mycobacterium tuberculosis with mortality and incidence of COVID-19
June 18, 2021 Kazuo Inoue, Saori Kashima

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created…
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Fig 1. Culminating measures model for the general population. by Shumway et al., CC BY 4.0

PLOS ONE Predictors of compliance with COVID-19 related non-pharmaceutical interventions among university students in the United States
June 18, 2021 Spencer G. Shumway, Jonas D. Hopper, Ethan R. Tolman, Daniel G. Ferguson, Gabriella Hubble, David Patterson, Jamie L. Jensen

The world is currently dealing with a devastating pandemic. Although growing COVID-19 case numbers, deaths, and hospitalizations are…
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Fig 3. Care needs of previously self-care patients after inpatient treatment of COVID-19 (n = 59). by Herrmann et al., CC BY 4.0

PLOS ONE COVID-19 in persons aged 70+ in an early affected German district: Risk factors, mortality and post-COVID care needs—A retrospective observational study of hospitalized and non-hospitalized patients
June 18, 2021 Matthias L. Herrmann, Johannes-Martin Hahn, Birgit Walter-Frank, Desiree M. Bollinger, Kristina Schmauder, Günter Schnauder, Michael Bitzer, Nisar P. Malek, Gerhard W. Eschweiler, Siri Göpel

Background: Cohorts of hospitalized COVID-19 patients have been studied in several countries since the beginning of the pandemic. So far,…
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Fig 3. Cumulative weekly case counts from March 1 to May 16, 2020 for the United States, New York, Washington, and Louisiana, as estimated by each method and the reported cases. by Lu et al., CC BY 4.0

PLOS Computational Biology Estimating the cumulative incidence of COVID-19 in the United States using influenza surveillance, virologic testing, and mortality data: Four complementary approaches
June 17, 2021 Fred S. Lu, Andre T. Nguyen, Nicholas B. Link, Mathieu Molina, Jessica T. Davis, Matteo Chinazzi, Xinyue Xiong, Alessandro Vespignani, Marc Lipsitch, Mauricio Santillana

Effectively designing and evaluating public health responses to the ongoing COVID-19 pandemic requires accurate estimation of the…
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Fig 1. Pathogen reproductive number, R_t, plotted against the ratio of contacts needing tracing to contact tracing capacity for variable delays (1/τ_Is) of 1–5 and 10 days between case symptom onset and the start of contact tracing (including getting tested and receiving result). by Gardner and Kilpatrick, CC BY 4.0

PLOS Computational Biology Contact tracing efficiency, transmission heterogeneity, and accelerating COVID-19 epidemics
June 17, 2021 Billy J. Gardner, A. Marm Kilpatrick

Simultaneously controlling COVID-19 epidemics and limiting economic and societal impacts presents a difficult challenge, especially with…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public Domain

PLOS ONE Post-infectious and post-acute sequelae of critically ill adults with COVID-19
June 17, 2021 Halah Ibrahim, Syed Athar, Thana Harhara, Shahad Abasaeed Elhag, Salma MElnour, Hoor H. Sukkar, Ashraf M. Kamour

Background: Data on the post-acute and post-infectious complications of patients who have recovered from severe coronavirus disease 2019…
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Fig 2. Heat map of symptomatic and sample of asymptomatic patients displaying time of enrollment, survey completion, time of symptom development, and follow-up. by Marcus et al., CC BY 4.0

PLOS ONE Predictors of incident viral symptoms ascertained in the era of COVID-19
June 17, 2021 Gregory M. Marcus, Jeffrey E. Olgin, Noah D. Peyser, Eric Vittinghoff, Vivian Yang, Sean Joyce, Robert Avram, Geoffrey H. Tison, David Wen, Xochitl Butcher, Helena Eitel, Mark J. Pletcher

Background: In the absence of universal testing, effective therapies, or vaccines, identifying risk factors for viral infection,…
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Fig 2. Antibody titers (AU/mL) classified by age group, gender and region of residence of donors. by Muttamba et al., CC BY 4.0

PLOS ONE Feasibility of collecting and processing of COVID-19 convalescent plasma for treatment of COVID-19 in Uganda
June 17, 2021 Winters Muttamba, John Lusiba, Loryndah Olive Namakula, Pauline Byakika-Kibwika, Francis Ssali, Henry Ddungu, Levicatus Mugenyi, Noah Kiwanuka, Rogers Sekibira, Cissy Kityo, Dorothy Keyune, Susan Acana, Ambrose Musinguzi, Ayub Masasi, Joseph Byamugisha, David Mpanju, Walter Jack Musoki, Hellen Aanyu Tukamuhebwa, Fred Nakwagala, Bernard Sentalo Bagaya, Alex Kayongo, Ivan Kimuli, Rebecca Nantanda, Winceslaus Katagira, Esther Buregyeya, Rosemary Byanyima, Baterana Byarugaba, Trishul Siddharthan, Henry Mwebesa, Olaro Charles, Moses Lutaakome Joloba, William Bazeyo, Bruce Kirenga

Introduction: Evidence that supports the use of COVID-19 convalescent plasma (CCP) for treatment of COVID-19 is increasingly emerging.…
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Fig 1. Histograms and smoothed density plots of the documented shedding (blue) and documented resolution (red) distributions. by Phillips et al., CC BY 4.0

PLOS ONE Duration of SARS-CoV-2 shedding: A population-based, Canadian study
June 17, 2021 Susan P. Phillips, Xuejiao Wei, Jeffrey C. Kwong, Jonathan Gubbay, Kevin L. Schwartz, Anna Majury, Patti A. Groome

Introduction: There is an evidence gap regarding the duration of SARS-CoV-2 shedding and of its variability across different care settings…
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Fig 1. Patient distribution of the 4704 included patients in Germany. by Gessler et al., CC BY 4.0

PLOS ONE Clinical outcome, risk assessment, and seasonal variation in hospitalized COVID-19 patients—Results from the CORONA Germany study
June 17, 2021 Nele Gessler, Melanie A. Gunawardene, Peter Wohlmuth, Dirk Arnold, Juergen Behr, Christian Gloeckner, Klaus Herrlinger, Thomas Hoelting, Ulrich-Frank Pape, Ruediger Schreiber, Axel Stang, Claas Wesseler, Stephan Willems, Charlotte Arms, Christoph U. Herborn

Background: After one year of the pandemic and hints of seasonal patterns, temporal variations of in-hospital mortality in COVID-19 are…
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Fig 1. Crude and directly standardized mortality rates in Switzerland for the period 1970–2020 (data from the Swiss Federal Statistical Office and the Human Mortality Database). by Locatelli and Rousson, CC BY 4.0

PLOS ONE A first analysis of excess mortality in Switzerland in 2020
June 17, 2021 Isabella Locatelli, Valentin Rousson

Objective: To quantify excess all-cause mortality in Switzerland in 2020, a key indicator for assessing direct and indirect consequences of…
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Fig 1. Axial Computed Tomography images of a 59 years-old male affected by COVID-19, hospitalized in a COVID-19 ward, demonstrating the applied method of measurements of muscle densitometry. by Giraudo et al., CC BY 4.0

PLOS ONE Reduced muscle mass as predictor of intensive care unit hospitalization in COVID-19 patients
June 17, 2021 Chiara Giraudo, Giovanni Librizzi, Giulia Fichera, Raffaella Motta, Elisabetta Balestro, Fiorella Calabrese, Giovanni Carretta, Anna Maria Cattelan, Paolo Navalesi, Michela Pelloso, Mario Plebani, Federico Rea, Roberto Vettor, Andrea Vianello, Roberto Stramare

Purpose: To evaluate if reduced muscle mass, assessed with Computed Tomography (CT), is a predictor of intensive care unit (ICU)…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public Domain

PLOS ONE Reported health and social consequences of the COVID-19 pandemic on vulnerable populations and implemented solutions in six West African countries: A media content analysis
June 16, 2021 Khalida Saalim, Kwame S. Sakyi, Fatema-Tuz-Zohra, Emily Morrison, Prince Owusu, Sarah L. Dalglish, Mufaro Kanyangarara

Coronavirus has spread worldwide with over 140 million cases and resulting in more than 3 million deaths between November 2019 to April…
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Fig 2. Forest plot of the prevalence of COVID-19 in ESRD patients with RRT. by Nopsopon et al., CC BY 4.0

PLOS Neglected Tropical Diseases Covid-19 in end-stage renal disease patients with renal replacement therapies: A systematic review and meta-analysis
June 15, 2021 Tanawin Nopsopon, Jathurong Kittrakulrat, Kullaya Takkavatakarn, Thanee Eiamsitrakoon, Talerngsak Kanjanabuch, Krit Pongpirul

Background: The novel coronavirus (COVID-19), caused by SARS-CoV-2, showed various prevalence and case-fatality rates (CFR) among patients…
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Fig 1. Comparison of clinic characteristics of COVID-19 patients in Mild-Moderate and Severe-Critically Severe groups (n = 196). by Luo et al., CC BY 4.0

PLOS ONE The selection of indicators from initial blood routine test results to improve the accuracy of early prediction of COVID-19 severity
June 15, 2021 Jiaqing Luo, Lingyun Zhou, Yunyu Feng, Bo Li, Shujin Guo

The global pandemic of COVID-19 poses a huge threat to the health and lives of people all over the world, and brings unprecedented…
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Fig 1. Sex and age-stratified COVID-19 incidence estimates by region (A, B and C), Peru, 2020. by Ramírez-Soto et al., CC BY 4.0

PLOS ONE Sex differences in the incidence, mortality, and fatality of COVID-19 in Peru
June 14, 2021 Max Carlos Ramírez-Soto, Hugo Arroyo-Hernández, Gutia Ortega-Cáceres

Background: There is a worrying lack of epidemiological data on the sex differential in COVID-19 infection and death rates between the…
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Fig 1. by Borse et al., CC BY 4.0

PLOS ONE Ayurveda botanicals in COVID-19 management: An in silico multi-target approach
June 11, 2021 Swapnil Borse, Manali Joshi, Akash Saggam, Vedika Bhat, Safal Walia, Aniket Marathe, Sneha Sagar, Preeti Chavan-Gautam, Aboli Girme, Lal Hingorani, Girish Tillu

The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there…
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Fig 1. Mortality Trends in COVID-19 admissions. by Coppock et al., CC BY 4.0

PLOS ONE COVID-19 treatment combinations and associations with mortality in a large multi-site healthcare system
June 11, 2021 Dagan Coppock, Michael Baram, Anna Marie Chang, Patricia Henwood, Alan Kubey, Ross Summer, John Zurlo, Michael Li, Bryan Hess

Introduction: During the early months of the COVID-19 pandemic, mortality associated with the disease declined in the United States. The…
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Fig 3. IgG levels in the patients during the three visits. by Alzaabi et al., CC BY 4.0

PLOS ONE Longitudinal changes in IgG levels among COVID-19 recovered patients: A prospective cohort study
June 11, 2021 Ashraf Hassan Alzaabi, Luai A. Ahmed, Abdulla E. Rabooy, Ali Al Zaabi, Mohammed Alkaabi, Falah AlMahmoud, Mai Farouk Hamed, Khalid Omar Bashaeb, Abdul Rahim Bakhsh, Suha Adil, Nadeen Elmajed, Ahmed Nigm Abousalha, Ahmad Kanaan Uwaydah, Khulood Al Mazrouei

Objectives: To quantify SARS-CoV2 IgG antibody titers over time and assess the longevity of the immune response in a multi-ethnic…
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Fig 1. Stability of SARS-CoV-2 RNA in a swab of saliva mixed with eNAT (A) or saliva diluted 1:2 with eNAT (B). by Banik et al., CC BY 4.0

PLOS ONE Inactivation of SARS-CoV-2 virus in saliva using a guanidium based transport medium suitable for RT-PCR diagnostic assays
June 11, 2021 Sukalyani Banik, Kaheerman Saibire, Shraddha Suryavanshi, Glenn Johns, Soumitesh Chakravorty, Robert Kwiatkowski, David Alland, Padmapriya P. Banada

Background: Upper respiratory samples used to test for SARS-CoV-2 virus may be infectious and present a hazard during transport and…
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Fig 1. by Fowler et al., CC BY 4.0

PLOS ONE Stay-at-home orders associate with subsequent decreases in COVID-19 cases and fatalities in the United States
June 10, 2021 James H. Fowler, Seth J. Hill, Remy Levin, Nick Obradovich

Governments issue “stay-at-home” orders to reduce the spread of contagious diseases, but the magnitude of such orders’ effectiveness…
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Fig 1. Different slices of CT scans representing each patients group. by Alves et al., CC BY 4.0

PLOS ONE Automatic algorithm for quantifying lung involvement in patients with chronic obstructive pulmonary disease, infection with SARS-CoV-2, paracoccidioidomycosis and no lung disease patients
June 10, 2021 Allan Felipe Fattori Alves, José Ricardo Arruda Miranda, Fabiano Reis, Abner Alves Oliveira, Sérgio Augusto Santana Souza, Carlos Magno Castelo Branco Fortaleza, Suzana Erico Tanni, José Thiago Souza Castro, Diana Rodrigues Pina

In this work, we aimed to develop an automatic algorithm for the quantification of total volume and lung impairments in four different…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public Domain

PLOS ONE Nurses’ core disaster-response competencies for combating COVID-19—A cross-sectional study
June 10, 2021 Igor Karnjuš, Mirko Prosen, Sabina Ličen

The core competencies in disaster nursing, nurses’ roles in disaster management and the potential barriers are assessed with a view to…
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Fig 1. Stay-at-home measure and number of new infections, Tokyo. by Watanabe and Yabu, CC BY 4.0

PLOS ONE Japan’s voluntary lockdown
June 10, 2021 Tsutomu Watanabe, Tomoyoshi Yabu

Japan’s government has taken a number of measures, including declaring a state of emergency, to combat the spread COVID-19. We examine the…
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Fig 1. Differences between German and Austrian GPs in their evaluation of the pandemic (Austria: n = 900; Germany: n = 1287). by Siebenhofer et al., CC BY 4.0

PLOS ONE COVI-Prim survey: Challenges for Austrian and German general practitioners during initial phase of COVID-19
June 10, 2021 Andrea Siebenhofer, Sebastian Huter, Alexander Avian, Karola Mergenthal, Dagmar Schaffler-Schaden, Ulrike Spary-Kainz, Herbert Bachler, Maria Flamm

Background: Coronavirus disease 2019 (COVID-19) represents a significant challenge to health care systems around the world. A…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public Domain

PLOS ONE Low level SARS-CoV-2 RNA detected in plasma samples from a cohort of Nigerians: Implications for blood transfusion
June 10, 2021 Azuka Patrick Okwuraiwe, Chika Kingsley Onwuamah, Joseph Ojonugwa Shaibu, Samuel Olufemi Amoo, Fehintola Anthonia Ige, Ayorinde Babatunde James, Leona Chika Okoli, Abul-Rahman Ahmed, Jamda Ponmak, Judith O. Sokei, Sulaimon Akanmu, Babatunde Lawal Salako, Rosemary Ajuma Audu

The present global pandemic triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has lingered for over a year in…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public Domain

PLOS ONE Investigation of superspreading COVID-19 outbreak events in meat and poultry processing plants in Germany: A cross-sectional study
June 10, 2021 Roman Pokora, Susan Kutschbach, Matthias Weigl, Detlef Braun, Annegret Epple, Eva Lorenz, Stefan Grund, Juergen Hecht, Helmut Hollich, Peter Rietschel, Frank Schneider, Roland Sohmen, Katherine Taylor, Isabel Dienstbuehl

Since May 2020, several COVID-19 outbreaks have occurred in the German meat industry despite various protective measures, and temperature…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Seroprevalence of anti-SARS-CoV-2 IgG antibodies in the staff of a public school system in the midwestern United States
June 10, 2021 Lilah Lopez, Thao Nguyen, Graham Weber, Katlyn Kleimola, Megan Bereda, Yiling Liu, Emma K. Accorsi, Steven J. Skates, John P. Santa Maria Jr., Kendal R. Smith, Mark Kalinich

Since March 2020, the United States has lost over 580,000 lives to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which…
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Fig 1. Viability of SARS-CoV-2 on stainless steel after exposure to simulated sunlight. by Sloan et al., CC BY 4.0

PLOS ONE Simulated sunlight decreases the viability of SARS-CoV-2 in mucus
June 10, 2021 Angela Sloan, Todd Cutts, Bryan D. Griffin, Samantha Kasloff, Zachary Schiffman, Mable Chan, Jonathan Audet, Anders Leung, Darwyn Kobasa, Derek R. Stein, David Safronetz, Guillaume Poliquin

The novel coronavirus, SARS-CoV-2, has spread into a pandemic since its emergence in Wuhan, China in December of 2019. This has been…
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Fig 1. Variability in SARS-CoV-2 IgG antibody response. by Schaefer et al., CC BY 4.0

PLOS ONE Corona Virus Disease-19 serology, inflammatory markers, hospitalizations, case finding, and aging
June 10, 2021 Ernst J. Schaefer, Latha Dulipsingh, Florence Comite, Jessica Jimison, Martin M. Grajower, Nathan E. Lebowitz, Maxine Lang, Andrew S. Geller, Margaret R. Diffenderfer, Lihong He, Gary Breton, Michael L. Dansinger, Ben Saida, Chong Yuan

Most deaths from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection occur in older subjects. We assessed the utility…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Screening for SARS-CoV-2 by RT-PCR: Saliva or nasopharyngeal swab? Rapid review and meta-analysis
June 10, 2021 Nusaïbah Ibrahimi, Agnès Delaunay-Moisan, Catherine Hill, Gwénaël Le Teuff, Jean-François Rupprecht, Jean-Yves Thuret, Dan Chaltiel, Marie-Claude Potier

Background: Diagnosis of COVID-19 in symptomatic patients and screening of populations for SARS-CoV-2 infection require access to…
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Fig 1. Treatment outcome among patients admitted with COVID-19 in WURH treatment. by Tolossa et al., CC BY 4.0

PLOS ONE Time to recovery from COVID-19 and its predictors among patients admitted to treatment center of Wollega University Referral Hospital (WURH), Western Ethiopia: Survival analysis of retrospective cohort study
June 10, 2021 Tadesse Tolossa, Bizuneh Wakuma, Dejene Seyoum Gebre, Emiru Merdassa Atomssa, Motuma Getachew, Getahun Fetensa, Diriba Ayala, Ebisa Turi

Introduction: Despite its alarming spread throughout the world, no effective drug and vaccine is discovered for COVID-19 so far. According…
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Fig 1. Distribution of treatment modalities over time. by Malhani et al., CC BY 4.0

PLOS ONE Combination of (interferon beta-1b, lopinavir/ritonavir and ribavirin) versus favipiravir in hospitalized patients with non-critical COVID-19: A cohort study
June 10, 2021 Areej A. Malhani, Mushira A. Enani, Fatemeh Saheb Sharif-Askari, Mona R. Alghareeb, Roaa T. Bin-Brikan, Safar A. AlShahrani, Rabih Halwani, Imad M. Tleyjeh

Objectives: Our study aims at comparing the efficacy and safety of IFN-based therapy (lopinavir/ritonavir, ribavirin, and interferon β-1b)…
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Fig 1. Racial discrepancies between NMH 2019 kidney transplant recipients and the SARS-CoV 2 positive kidney transplant recipient cohort. by Nahi et al., CC BY 4.0

PLOS ONE Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience
June 10, 2021 Skylar L. Nahi, Aneesha A. Shetty, Sajal D. Tanna, Joseph R. Leventhal

Background: Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their…
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Fig 1. The numbers of matched nasopharyngeal and saliva samples. by Ota et al., CC BY 4.0

PLOS ONE Detection of SARS-CoV-2 using qRT-PCR in saliva obtained from asymptomatic or mild COVID-19 patients, comparative analysis with matched nasopharyngeal samples
June 10, 2021 Kenji Ota, Katsunori Yanagihara, Daisuke Sasaki, Norihito Kaku, Naoki Uno, Kei Sakamoto, Kosuke Kosai, Taiga Miyazaki, Hiroo Hasegawa, Ayumi Fujita, Masato Tashiro, Takeshi Tanaka, Koichi Izumikawa, Koya Ariyoshi, Hiroshi Mukae, Jiro Yasuda, Kouichi Morita, Shigeru Kohno

Objectives: The accurate detection of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is essential for the diagnosis of…
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Fig 3. Survival curves, regarding the primary outcome, comparing HCQ/AZI and control group. by Saib et al., CC BY 4.0

PLOS ONE Lack of efficacy of hydroxychloroquine and azithromycin in patients hospitalized for COVID-19 pneumonia: A retrospective study
June 9, 2021 Anis Saib, Walid Amara, Pascal Wang, Simon Cattan, Azeddine Dellal, Kais Regaieg, Stephane Nahon, Olivier Nallet, Lee S. Nguyen

Background: Hydroxychloroquine combined with azithromycin (HCQ/AZI) has initially been used against coronavirus disease-2019 (COVID-19). In…
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Fig 1. Generation of SARS-CoV2-SP-pseudotyped lentivirus particles (SCoV-2-SP-PVs). by Ao et al., CC BY 4.0

PLOS ONE Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry
June 9, 2021 Zhujun Ao, Mable Chan, Maggie Jing Ouyang, Titus Abiola Olukitibi, Mona Mahmoudi, Darwyn Kobasa, Xiaojian Yao

Until now, antiviral therapeutic agents are still urgently required for treatment or prevention of SARS-coronavirus 2 (SCoV-2) virus…
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Novel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public Domain

PLOS ONE Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study
June 9, 2021 Francisco Purroy, Gloria Arqué

Background: COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of…
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Fig 2. Estimated basic reproduction numbers (R₀) for countries across the globe. by Kong et al., CC BY 4.0

PLOS ONE Social, economic, and environmental factors influencing the basic reproduction number of COVID-19 across countries
June 9, 2021 Jude Dzevela Kong, Edward W. Tekwa, Sarah A. Gignoux-Wolfsohn

Objective: To assess whether the basic reproduction number (R0) of COVID-19 is different across countries and what national-level…
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Fig 2. by Poschenrieder et al., CC BY 4.0

PLOS ONE Severe COVID-19 pneumonia: Perfusion analysis in correlation with pulmonary embolism and vessel enlargement using dual-energy CT data
June 8, 2021 Florian Poschenrieder, Stefanie Meiler, Matthias Lubnow, Florian Zeman, Janine Rennert, Gregor Scharf, Jan Schaible, Christian Stroszczynski, Michael Pfeifer, Okka W. Hamer

Background: Gas exchange in COVID-19 pneumonia is impaired and vessel obstruction has been suspected to cause ventilation-perfusion…
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Fig 1. The global model collects local models updates. by Abdul Salam et al., CC BY 4.0

PLOS ONE COVID-19 detection using federated machine learning
June 8, 2021 Mustafa Abdul Salam, Sanaa Taha, Mohamed Ramadan

The current COVID-19 pandemic threatens human life, health, and productivity. AI plays an essential role in COVID-19 case classification…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Excess mortality by specific causes of deaths in the city of São Paulo, Brazil, during the COVID-19 pandemic
June 7, 2021 Gisele Aparecida Fernandes, Antonio Paulo Nassar Junior, Gulnar Azevedo e Silva, Diego Feriani, Ivan Leonardo Avelino França e Silva, Pedro Caruso, Maria Paula Curado

Background: To investigate the excess of deaths by specific causes, in the first half of 2020 in the city of São Paulo-Brazil, during the…
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Fig 3. Representative case without COVID-19 pneumonia. by Hwang et al., CC BY 4.0

PLOS ONE COVID-19 pneumonia on chest X-rays: Performance of a deep learning-based computer-aided detection system
June 7, 2021 Eui Jin Hwang, Ki Beom Kim, Jin Young Kim, Jae-Kwang Lim, Ju Gang Nam, Hyewon Choi, Hyungjin Kim, Soon Ho Yoon, Jin Mo Goo, Chang Min Park

Chest X-rays (CXRs) can help triage for Coronavirus disease (COVID-19) patients in resource-constrained environments, and a computer-aided…
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Fig 2. Timeline of SARS-CoV-2 R.1 lineage emergence and country-specific percentages of global cases. by Hirotsu and Omata, CC BY 4.0

PLOS Pathogens Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan
June 7, 2021 Yosuke Hirotsu, Masao Omata

We aimed to investigate novel emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages in Japan that harbor variants…
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Fig 2. Marginal effects of temperature (t-14) on Covid-19 fatalities (direct effect with DFE estimates). by Damette et al., CC BY 4.0

PLOS ONE Meteorological factors against COVID-19 and the role of human mobility
June 4, 2021 Olivier Damette, Clément Mathonnat, Stéphane Goutte

In the vein of recent empirical literature, we reassessed the impact of weather factors on Covid-19 daily cases and fatalities in a panel…
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Fig 1. Relative excess mortality among Californians 18–65 years of age, March through November 2020. by Chen et al., CC BY 4.0

PLOS ONE Excess mortality associated with the COVID-19 pandemic among Californians 18–65 years of age, by occupational sector and occupation: March through November 2020
June 4, 2021 Yea-Hung Chen, Maria Glymour, Alicia Riley, John Balmes, Kate Duchowny, Robert Harrison, Ellicott Matthay, Kirsten Bibbins-Domingo

Background: Though SARS-CoV-2 outbreaks have been documented in occupational settings and in-person essential work has been suspected as a…
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Fig 2. Proportions of pooling of secretions and recommendations of oral intake in COVID-19 patients treated in the ICU at the time of the first FEES examination. by Osbeck Sandblom et al., CC BY 4.0

PLOS ONE Characterization of dysphagia and laryngeal findings in COVID-19 patients treated in the ICU—An observational clinical study
June 4, 2021 Hanna Osbeck Sandblom, Hans Dotevall, Kristina Svennerholm, Lisa Tuomi, Caterina Finizia

Background: Dysphagia appears to be common in patients with severe COVID-19. Information about the characteristics of dysphagia and…
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Fig 2. Day 0 plasma ACE2 in COVID-19 positive patients by clinical outcome group and ROC curve. by Kragstrup et al., CC BY 4.0

PLOS ONE Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients
June 4, 2021 Tue W. Kragstrup, Helene Søgaard Singh, Ida Grundberg, Ane Langkilde-Lauesen Nielsen, Felice Rivellese, Arnav Mehta, Marcia B. Goldberg, Michael R. Filbin, Per Qvist, Bo Martin Bibby

Aims: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) enabling entrance of the…
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sadness by Georgie Pauwels, CC BY 2.0

PLOS ONE Assessment of depressive symptoms in patients with COVID-19 during the second wave of epidemic in Myanmar: A cross-sectional single-center study
June 4, 2021 Ye Minn Htun, Kyaw Thiha, Aung Aung, Nay Myo Aung, Thet Wai Oo, Pyae Sone Win, Nay Hein Sint, Kaung Myat Naing, Aung Khant Min, Kyaw Myo Tun, Kyaw Hlaing

Background: Coronavirus disease 2019 (COVID-19) pandemic has had a great impact on every aspect of society. All countries launched…
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Fig 1. Baseline and highest or lowest values for selected laboratory values in ESKD and non-ESKD groups. by Kamel et al., CC BY 4.0

PLOS ONE End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts
June 4, 2021 Mohamed Hassan Kamel, Hassan Mahmoud, Aileen Zhen, Jing Liu, Catherine G. Bielick, Anahita Mostaghim, Nina Lin, Vipul Chitalia, Titilayo Ilori, Sushrut S. Waikar, Ashish Upadhyay

Introduction: End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we…
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Fig 1. Schematic diagram of the contact tracing model. by James et al., CC BY 4.0

PLOS ONE Successful contact tracing systems for COVID-19 rely on effective quarantine and isolation
June 3, 2021 A. James, M. J. Plank, S. Hendy, R. Binny, A. Lustig, N. Steyn, A. Nesdale, A. Verrall

Models of contact tracing often over-simplify the effects of quarantine and isolation on disease transmission. We develop a model that…
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Fig 1. Data extraction and processing. by Tortolero et al., CC BY 4.0

PLOS ONE Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality
June 3, 2021 Guillermo A. Tortolero, Michael R. Brown, Shreela V. Sharma, Marcia C. de Oliveira Otto, Jose-Miguel Yamal, David Aguilar, Matt D. Gunther, Dania I. Mofleh, Rachel D. Harris, Jemima C. John, Paul S. de Vries, Ryan Ramphul, Dritana Marko Serbo, Jennifer Kiger, Deborah Banerjee, Nick Bonvino, Angela Merchant, Warren Clifford, Jenny Mikhail, Hua Xu, Robert E. Murphy, Qiang Wei, Farhaan S. Vahidy, Alanna C. Morrison, Eric Boerwinkle

Understanding sociodemographic, behavioral, clinical, and laboratory risk factors in patients diagnosed with COVID-19 is critically…
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Fig 2. PCA plot of IgM and IgG pan-CoV responses. by Chaudhury et al., CC BY 4.0

PLOS ONE Serological profiles of pan-coronavirus-specific responses in COVID-19 patients using a multiplexed electro-chemiluminescence-based testing platform
June 3, 2021 Sidhartha Chaudhury, Jack Hutter, Jessica S. Bolton, Shilpa Hakre, Evelyn Mose, Amy Wooten, William O’Connell, Joseph Hudak, Shelly J. Krebs, Janice M. Darden, Jason A. Regules, Clinton K. Murray, Kayvon Modjarrad, Paul Scott, Sheila Peel, Elke S. Bergmann-Leitner

Serological assessment of SARS-CoV-2 specific responses are an essential tool for determining the prevalence of past SARS-CoV-2 infections…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE The benefits of coronavirus suppression: A cost-benefit analysis of the response to the first wave of COVID-19 in the United States
June 3, 2021 James Broughel, Michael Kotrous

This paper estimates the benefits and costs of state suppression policies to “bend the curve” during the initial outbreak of COVID-19 in…
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Fig 1. Flowchart of patients included in our analysis. by Sen et al., CC BY 4.0

PLOS ONE Inhaled corticosteroids do not adversely impact outcomes in COVID-19 positive patients with COPD: An analysis of Cleveland Clinic’s COVID-19 registry
June 3, 2021 Payal Sen, Uddalak Majumdar, Joe Zein, Umur Hatipoğlu, Amy H. Attaway

Inhaled Corticosteroids (ICS) are commonly prescribed to patients with severe COPD and recurrent exacerbations. It is not known what…
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Fig 2. A one-way disposable sampling valve protected participants. by Snitz et al., CC BY 4.0

PLOS ONE Proof of concept for real-time detection of SARS CoV-2 infection with an electronic nose
June 2, 2021 Kobi Snitz, Michal Andelman-Gur, Liron Pinchover, Reut Weissgross, Aharon Weissbrod, Eva Mishor, Roni Zoller, Vera Linetsky, Abebe Medhanie, Sagit Shushan, Eli Jaffe, Noam Sobel

Rapid diagnosis is key to curtailing the Covid-19 pandemic. One path to such rapid diagnosis may rely on identifying volatile organic…
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Fig 1. Timing of NPIs by country. by Banholzer et al., CC BY 4.0

PLOS ONE Estimating the effects of non-pharmaceutical interventions on the number of new infections with COVID-19 during the first epidemic wave
June 2, 2021 Nicolas Banholzer, Eva van Weenen, Adrian Lison, Alberto Cenedese, Arne Seeliger, Bernhard Kratzwald, Daniel Tschernutter, Joan Puig Salles, Pierluigi Bottrighi, Sonja Lehtinen, Stefan Feuerriegel, Werner Vach

The novel coronavirus (SARS-CoV-2) has rapidly developed into a global epidemic. To control its spread, countries have implemented…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS Neglected Tropical Diseases Ivermectin as a potential treatment for COVID-19?
June 1, 2021 Olivier Chosidow, Charlotte Bernigaud, Didier Guillemot, Bruno Giraudeau, Anne Lespine, Jean-Pierre Changeux, Hervé Bourhy, Marc Lecuit, Zahir Amoura

…
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Fig 1. SDS-PAGE analysis of SARS-CoV-2 S1 spike-specific IgY carried out under reducing conditions. by Artman et al., CC BY 4.0

PLOS ONE Avian antibodies (IgY) targeting spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit receptor binding and viral replication
May 28, 2021 Chad Artman, Kyle D. Brumfield, Sahil Khanna, Julius Goepp

Background: The global pandemic of Coronavirus infectious disease 2019 (COVID-19), caused by SARS-CoV-2, has plunged the world into both…
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Fig 3. PCA plot (Day 90). by Teh et al., CC BY 4.0

PLOS ONE Multivariate visualization of the global COVID-19 pandemic: A comparison of 161 countries
May 28, 2021 Jane K. L. Teh, David A. Bradley, Jack Bee Chook, Kee Huong Lai, Woo Teck Ang, Kok Lay Teo, Suat-Cheng Peh

Background: The aim of the study was to visualize the global spread of the COVID-19 pandemic over the first 90 days, through the principal…
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Fig 2. CLIR plot by multiple conditions of 159 DBS samples with serum SARS-CoV-2 antibody results. by Turgeon et al., CC BY 4.0

PLOS ONE Validation of a multiplex flow immunoassay for detection of IgG antibodies against SARS-CoV-2 in dried blood spots
May 28, 2021 Coleman T. Turgeon, Karen A. Sanders, Piero Rinaldo, Dane Granger, Heather Hilgart, Dietrich Matern, Elitza S. Theel

Background: Dried blood spots (DBS) are an established specimen type for clinical testing given their low cost, ease of collection and…
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Fig 2. Sensitivity of PanBio Ag-RDT compared to viral load for all PCR positive cases (105 participants). by Krüger et al., CC BY 4.0

PLOS ONE The Abbott PanBio WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic test for SARS-CoV-2—Evaluation of the accuracy and ease-of-use
May 27, 2021 Lisa J. Krüger, Mary Gaeddert, Frank Tobian, Federica Lainati, Claudius Gottschalk, Julian A. F. Klein, Paul Schnitzler, Hans-Georg Kräusslich, Olga Nikolai, Andreas K. Lindner, Frank P. Mockenhaupt, Joachim Seybold, Victor M. Corman, Christian Drosten, Nira R. Pollock, Britta Knorr, Andreas Welker, Margaretha de Vos, Jilian A. Sacks, Claudia M. Denkinger, for the study team

Objectives: Diagnostics are essential for controlling the pandemic. Identifying a reliable and fast diagnostic device is needed for…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Determinants of in-hospital mortality in COVID-19; a prospective cohort study from Pakistan
May 27, 2021 Samreen Sarfaraz, Quratulain Shaikh, Syed Ghazanfar Saleem, Anum Rahim, Fivzia Farooq Herekar, Samina Junejo, Aneela Hussain

A prospective cohort study was conducted at the Indus Hospital Karachi, Pakistan between March and June 2020 to estimate the in-hospital…
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Syringe and Vaccine by NIH, CC BY 2.0

PLOS ONE Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda
May 27, 2021 Jonathan Kitonsa, Onesmus Kamacooko, Ubaldo Mushabe Bahemuka, Freddie Kibengo, Ayoub Kakande, Anne Wajja, Vincent Basajja, Alfred Lumala, Edward Ssemwanga, Robert Asaba, Joseph Mugisha, Benjamin F. Pierce, Robin Shattock, Pontiano Kaleebu, Eugene Ruzagira

Background: Healthcare workers (HCWs) are at high risk of acquiring SARS-CoV-2 and COVID-19 and may therefore be a suitable population for…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE The systemic inflammatory response and clinicopathological characteristics in patients admitted to hospital with COVID-19 infection: Comparison of 2 consecutive cohorts
May 27, 2021 Donogh Maguire, Conor Richards, Marylynne Woods, Ross Dolan, Jesse Wilson Veitch, Wei M. J. Sim, Olivia E. H. Kemmett, David C. Milton, Sophie L. W. Randall, Ly D. Bui, Nicola Goldmann, Amy Brown, Eilidh Gillen, Allan Cameron, Barry Laird, Dinesh Talwar, Ian M. Godber, John Wadsworth, Anthony Catchpole, Alan Davidson, Donald C. McMillan

Background: In order to manage the COVID-19 systemic inflammatory response, it is important to identify clinicopathological characteristics…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Seroprevalence of SARS-CoV-2 antibodies in Seattle, Washington: October 2019–April 2020
May 27, 2021 Denise J. McCulloch, Michael L. Jackson, James P. Hughes, Sandra Lester, Lisa Mills, Brandi Freeman, Mohammad Ata Ur Rasheed, Natalie J. Thornburg, Helen Y. Chu

Background: The first US case of SARS-CoV-2 infection was detected on January 20, 2020. However, some serology studies suggest SARS-CoV-2…
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Fig 2. by Dragon-Durey et al., CC BY 4.0

PLOS ONE Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity
May 26, 2021 Marie-Agnès Dragon-Durey, Xiaoyi Chen, Amos Kirilovsky, Nadine Ben Hamouda, Carine El Sissy, Jules Russick, Etienne Charpentier, Yannick Binois, Florence Marliot, Maxime Meylan, Clémence Granier, Hélène Pere, Antonin Saldmann, Bastien Rance, Anne Sophie Jannot, Stéphanie Baron, Mouna Chebbi, Antoine Fayol, Nathalie Josseaume, Claire Rives-Lange, Pierre-Louis Tharaux, Bernard Cholley, Jean-Luc Diehl, Jean-Benoît Arlet, Michel Azizi, Alexandre Karras, Sébastien Czernichow, David M. Smadja, Jean-Sébastien Hulot, Isabelle Cremer, Eric Tartour, Elie Mousseaux, Franck Pagès

To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective…
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Fig 2. The SARS-CoV-2 outbreak in the Netherlands. by Tomokazu Konishi, CC BY 4.0

PLOS ONE SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans
May 26, 2021 Tomokazu Konishi

SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to…
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Fig 3. Identiication of SARS-CoV-2 genetic clusters in different continents. by Haddad et al., CC BY 4.0

PLOS ONE SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains
May 25, 2021 Dania Haddad, Sumi Elsa John, Anwar Mohammad, Maha M. Hammad, Prashantha Hebbar, Arshad Channanath, Rasheeba Nizam, Sarah Al-Qabandi, Ashraf Al Madhoun, Abdullah Alshukry, Hamad Ali, Thangavel Alphonse Thanaraj, Fahd Al-Mulla

COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this…
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Fig 3. by Pinzón et al., CC BY 4.0

PLOS ONE Dexamethasone vs methylprednisolone high dose for Covid-19 pneumonia
May 25, 2021 Miguel Alejandro Pinzón, Santiago Ortiz, Héctor Holguín, Juan Felipe Betancur, Doris Cardona Arango, Henry Laniado, Carolina Arias Arias, Bernardo Muñoz, Julián Quiceno, Daniel Jaramillo, Zoraida Ramirez

Background: There is no effective therapy for the severe acute respiratory syndrome by coronavirus 2 (SARS-CoV2) responsible for the…
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Fig 3. Correlation matrix among clinical variables at hospital admission and discharge. by de Almeida et al., CC BY 4.0

PLOS ONE Acute kidney injury: Incidence, risk factors, and outcomes in severe COVID-19 patients
May 25, 2021 Danilo Candido de Almeida, Maria do Carmo Pinho Franco, Davi Rettori Pardo dos Santos, Marina Colella Santos, Isabela Soucin Maltoni, Felipe Mascotte, Alexandra Aparecida de Souza, Paula Massaroni Pietrobom, Eduardo Alexandrino Medeiros, Paulo Roberto Abrão Ferreira, Flavia Ribeiro Machado, Miguel Angelo Goes

Background: COVID-19 is a multisystemic disorder that frequently causes acute kidney injury (AKI). However, the precise clinical and…
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Fig 2. Hypothetical model for thrombotic thrombocytopenia after adenoviral vector-based COVID-19 vaccines. by Goldman and Hermans, CC BY 4.0

PLOS Medicine Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity
May 24, 2021 Michel Goldman, Cédric Hermans

Michel Goldman and Cédric Hermans discuss thrombotic mechanisms in COVID-19 and rare adverse reactions to SARS-CoV-2…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS Neglected Tropical Diseases COVID-19 and helminth infection: Beyond the Th1/Th2 paradigm
May 24, 2021 Alberto E. Paniz-Mondolfi, Juan David Ramírez, Lourdes A. Delgado-Noguera, Alfonso J. Rodriguez-Morales, Emilia M. Sordillo

…
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Fig 1. Forest plot of willingness to vaccinate by demographics. by Nikolovski et al., CC BY 4.0

PLOS ONE Factors indicating intention to vaccinate with a COVID-19 vaccine among older U.S. adults
May 24, 2021 Janeta Nikolovski, Martin Koldijk, Gerrit Jan Weverling, John Spertus, Mintu Turakhia, Leslie Saxon, Mike Gibson, John Whang, Troy Sarich, Robert Zambon, Nnamdi Ezeanochie, Jennifer Turgiss, Robyn Jones, Jeff Stoddard, Paul Burton, Ann Marie Navar

Background: The success of vaccination efforts to curb the COVID-19 pandemic will require broad public uptake of immunization and…
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Fig 3. Clinical SARS-CoV-2 RT-PCR sensitivity estimates in the laboratory confirmed, and in the laboratory confirmed and high suspicion group combined, presented according to delay (days) from symptom onset to sampling. by Kortela et al., CC BY 4.0

PLOS ONE Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients
May 21, 2021 Elisa Kortela, Vesa Kirjavainen, Maarit J. Ahava, Suvi T. Jokiranta, Anna But, Anna Lindahl, Anu E. Jääskeläinen, Annemarjut J. Jääskeläinen, Asko Järvinen, Pia Jokela, Hannimari Kallio-Kokko, Raisa Loginov, Laura Mannonen, Eeva Ruotsalainen, Tarja Sironen, Olli Vapalahti, Maija Lappalainen, Hanna-Riikka Kreivi, Hanna Jarva, Satu Kurkela, Eliisa Kekäläinen

Background: Understanding the false negative rates of SARS-CoV-2 RT-PCR testing is pivotal for the management of the COVID-19 pandemic and…
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Fig 1. Difference between the 2020 all-cause mortality rate and 2013–2018 historical mortality rate vs. 2020 direct COVID-19 mortality rate (n = 2,096)^a,b,c. by Stokes et al., CC BY 4.0

PLOS Medicine COVID-19 and excess mortality in the United States: A county-level analysis
May 20, 2021 Andrew C. Stokes, Dielle J. Lundberg, Irma T. Elo, Katherine Hempstead, Jacob Bor, Samuel H. Preston

Background: Coronavirus Disease 2019 (COVID-19) excess deaths refer to increases in mortality over what would normally have been expected…
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Fig 3. Geographical distribution of pregnant women with COVID-19, and medical facilities where community-acquired infection of COVID-19 occurred in Japan (-2020 June). by Hasegawa et al., CC BY 4.0

PLOS ONE Current status of community-acquired infection of COVID-19 in delivery facilities in Japan
May 20, 2021 Junichi Hasegawa, Tatsuya Arakaki, Akihiko Sekizawa, Tomoaki Ikeda, Isamu Ishiwata, Katsuyuki Kinoshita, on behalf of department of medical safety, the Japan Association of Obstetricians and Gynecologists (JAOG)

A nationwide questionnaire survey about community-acquired infection of coronavirus disease 2019 (COVID-19) was conducted in July 2020 to…
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Fig 3. Funnel plot of the association between the DPP-4i use and the mortality of COVID-19. by Yang et al., CC BY 4.0

PLOS ONE DPP-4 inhibitors may improve the mortality of coronavirus disease 2019: A meta-analysis
May 20, 2021 Yan Yang, Zixin Cai, Jingjing Zhang

Aims: DPP-4 inhibitors are predicted to exert a protective effect on the progression of coronavirus disease 2019 (COVID-19). We conducted…
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Fig 7. Receiver operating characteristic (ROC) curves analysis of total score for assessing the risk of respiratory support in COVID-19. by Rorat et al., CC BY 4.0

PLOS ONE Value of quantitative analysis in lung computed tomography in patients severely ill with COVID-19
May 20, 2021 Marta Rorat, Tomasz Jurek, Krzysztof Simon, Maciej Guziński

Introduction: Quantitative computed tomography (QCT) is used to objectively assess the degree of parenchymal impairment in COVID-19…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Incidence of deep vein thrombosis through an ultrasound surveillance protocol in patients with COVID-19 pneumonia in non-ICU setting: A multicenter prospective study
May 20, 2021 Filippo Pieralli, Fulvio Pomero, Margherita Giampieri, Rossella Marcucci, Domenico Prisco, Fabio Luise, Antonio Mancini, Alessandro Milia, Lucia Sammicheli, Irene Tassinari, Francesca Caldi, Francesca Innocenti, Antonio Faraone, Chiara Beltrame, Riccardo Pini, Andrea Ungar, Alberto Fortini

Objective: The aim of this study was to assess the incidence of deep vein thrombosis (DVT) of the lower limbs, using serial compression…
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Fig 2. OneR model diagnostic plot. by Herzog et al., CC BY 4.0

PLOS ONE COVID-19 and the kidney: A retrospective analysis of 37 critically ill patients using machine learning
May 20, 2021 Anna Laura Herzog, Holger K. von Jouanne-Diedrich, Christoph Wanner, Dirk Weismann, Tobias Schlesinger, Patrick Meybohm, Jan Stumpner

Introduction: There is evidence that SARS-CoV2 has a particular affinity for kidney tissue and is often associated with kidney failure.…
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Untitled by Dellicour et al., CC BY 4.0

PLOS Pathogens Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
May 20, 2021 Simon Dellicour, Samuel L. Hong, Bram Vrancken, Antoine Chaillon, Mandev S. Gill, Matthew T. Maurano, Sitharam Ramaswami, Paul Zappile, Christian Marier, Gordon W. Harkins, Guy Baele, Ralf Duerr, Adriana Heguy

During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While…
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Fig 2. Neuron-Specific Enolase (NSE) serum levels. by Cione et al., CC BY 4.0

PLOS ONE Neuron-specific enolase serum levels in COVID-19 are related to the severity of lung injury
May 19, 2021 Erika Cione, Antonio Siniscalchi, Pietro Gangemi, Lucio Cosco, Manuela Colosimo, Federico Longhini, Filippo Luciani, Giovambattista De Sarro, G&SP Working Group , Liberato Berrino, Bruno D’Agostino, Luca Gallelli

The multifunctional role of neuron-specific enolase (NSE) in lung diseases is well established. As the lungs are greatly affected in…
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Pregnant woman by sergio santos, CC BY 2.0

PLOS ONE Available medications used as potential therapeutics for COVID-19: What are the known safety profiles in pregnancy
May 19, 2021 Anick Bérard, Odile Sheehy, Jin-Ping Zhao, Evelyne Vinet, Caroline Quach, Behrouz Kassai, Sasha Bernatsky

Background: Medications already available to treat other conditions are presently being studied in clinical trials as potential treatments…
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Untitled by Garzon-Chavez et al., CC BY 4.0

PLOS ONE Adapting for the COVID-19 pandemic in Ecuador, a characterization of hospital strategies and patients
May 17, 2021 Daniel Garzon-Chavez, Daniel Romero-Alvarez, Marco Bonifaz, Juan Gaviria, Daniel Mero, Narcisa Gunsha, Asiris Perez, María Garcia, Hugo Espejo, Franklin Espinosa, Edison Ligña, Mauricio Espinel, Emmanuelle Quentin, Enrique Teran, Francisco Mora, Jorge Reyes

The World Health Organization (WHO) declared coronavirus disease-2019 (COVID-19) a global pandemic on 11 March 2020. In Ecuador, the first…
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Fig 2. Resonant frequencies f (in GHz) corresponding to respective V_L (in m/s) for different diameters D (in nm) of EV71 virus. by Barbora and Minnes, CC BY 4.0

PLOS ONE Targeted antiviral treatment using non-ionizing radiation therapy for SARS-CoV-2 and viral pandemics preparedness: Technique, methods and practical notes for clinical application
May 14, 2021 Ayan Barbora, Refael Minnes

Objective: Pandemic outbreaks necessitate effective responses to rapidly mitigate and control the spread of disease and eliminate the…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients
May 14, 2021 Giulia Besutti, Massimo Pellegrini, Marta Ottone, Michele Cantini, Jovana Milic, Efrem Bonelli, Giovanni Dolci, Giulia Cassone, Guido Ligabue, Lucia Spaggiari, Pierpaolo Pattacini, Tommaso Fasano, Simone Canovi, Marco Massari, Carlo Salvarani, Giovanni Guaraldi, Paolo Giorgi Rossi, on behalf of the Reggio Emilia COVID-19 Working Group

We assessed the impact of chest CT body composition parameters on outcomes and disease severity at hospital presentation of COVID-19…
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Fig 1. Temporal distribution of COVID-19 cases and their deaths in the capitals of the Northeast of Brazil. by Costa de Assis et al., CC BY 4.0

PLOS ONE Primary health care and social isolation against COVID-19 in Northeastern Brazil: Ecological time-series study
May 13, 2021 Sanderson José Costa de Assis, Johnnatas Mikael Lopes, Marcello Barbosa Otoni Gonçalves Guedes, Geronimo José Bouzas Sanchis, Diego Neves Araujo, Angelo Giuseppe Roncalli

Background: Brazil is witnessing a massive increase of corona virus disease (COVID-19). Its peculiar primary health care (PHC) system faces…
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Fig 4. Lockdown and travel restriction policy intensity from government and agent over time. by Kwak et al., CC BY 4.0

PLOS ONE Deep reinforcement learning approaches for global public health strategies for COVID-19 pandemic
May 13, 2021 Gloria Hyunjung Kwak, Lowell Ling, Pan Hui

Background: Unprecedented public health measures have been used during this coronavirus 2019 (COVID-19) pandemic to control the spread of…
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Fig 3. p-values of the differences between non-ARDS patients and ARDS patients for the four immunoassays at different time points. by Buchholtz et al., CC BY 4.0

PLOS ONE SARS-CoV-2 antibody immunoassays in serial samples reveal earlier seroconversion in acutely ill COVID-19 patients developing ARDS
May 13, 2021 Marie-Luise Buchholtz, Florian M. Arend, Peter Eichhorn, Michael Weigand, Alisa Kleinhempel, Kurt Häusler, Mathias Bruegel, Lesca M. Holdt, Daniel Teupser

Objectives: During the COVID-19 pandemic, SARS-CoV-2 antibody testing has been suggested for (1) screening populations for disease…
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Fig 2. by Peng et al., CC BY 4.0

PLOS ONE Clinical course and management of 73 hospitalized moderate patients with COVID-19 outside Wuhan
May 13, 2021 Xiaojuan Peng, Qi Liu, Zhaolin Chen, Guiyan Wen, Qing Li, Yanfang Chen, Jie Xiong, Xinzhou Meng, Yuanjin Ding, Ying Shi, Shaohui Tang

Moderate cases account for the majority in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
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Fig 1. Scheme of the possible infection rules according to RhD blood types and ABO ones. by Miotto et al., CC BY 4.0

PLOS ONE Does blood type affect the COVID-19 infection pattern?
May 13, 2021 Mattia Miotto, Lorenzo Di Rienzo, Giorgio Gosti, Edoardo Milanetti, Giancarlo Ruocco

Among the many aspects that characterize the COVID-19 pandemic, two seem particularly challenging to understand: i) the great geographical…
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Fig 2. Diagram for the flow of participants for part 2 of the study (qRT-PCR positive participants only). by Van der Moeren et al., CC BY 4.0

PLOS ONE Evaluation of the test accuracy of a SARS-CoV-2 rapid antigen test in symptomatic community dwelling individuals in the Netherlands
May 13, 2021 Nathalie Van der Moeren, Vivian F. Zwart, Esther B. Lodder, Wouter Van den Bijllaardt, Harald R. J. M. Van Esch, Joep J. J. M. Stohr, Joost Pot, Ineke Welschen, Petra M. F. Van Mechelen, Suzan D. Pas, Jan A. J. W. Kluytmans

Background: SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction (qRT-PCR) is well suited for the diagnosis of clinically…
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Fig 1. Location of Mutukula border entry point into Uganda. by Nsawotebba et al., CC BY 4.0

PLOS ONE Effectiveness of thermal screening in detection of COVID-19 among truck drivers at Mutukula Land Point of Entry, Uganda
May 13, 2021 Andrew Nsawotebba, Ivan Ibanda, Isaac Ssewanyana, Patrick Ogwok, Francis Ocen, Christopher Okiira, Atek Kagirita, Dennis Mujuni, Didas Tugumisirize, Joel Kabugo, Abdunoor Nyombi, Robert Kaos Majwala, Bernard Ssentalo Bagaya, Simeon Kalyesubula-Kibuuka, Willy Ssengooba, Susan Nabadda

Introduction: Despite the limited evidence for its effectiveness, thermal screening at points of entry has increasingly become a standard…
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Fig 1. COVID-19 postmortem donor eye. by Bayyoud et al., CC BY 4.0

PLOS ONE Severe acute respiratory Syndrome-Coronavirus-2: Can it be detected in the retina?
May 13, 2021 Tarek Bayyoud, Angelika Iftner, Thomas Iftner, Karl Ulrich Bartz-Schmidt, Focke Ziemssen, Hans Bösmüller, Falko Fend, Jens Martin Rohrbach, Marius Ueffing, Michael Schindler, Sebastian Thaler

Background/Objectives: The systemic organ involvement of SARS-CoV-2 needs to be thoroughly investigated including the possibility of an…
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Fig 1. Changes in FEV₁ (% of predicted) among patients who tested positive for SARS-CoV-2 (cases) by PCR analysis and those who tested negative (controls)^a. by Colombo et al., CC BY 4.0

PLOS ONE SARS-CoV-2 infection in cystic fibrosis: A multicentre prospective study with a control group, Italy, February-July 2020
May 13, 2021 Carla Colombo, Gianfranco Alicandro, Valeria Daccó, Vanessa Gagliano, Letizia Corinna Morlacchi, Rosaria Casciaro, Giovanna Pisi, Michela Francalanci, Raffaele Badolato, Elisabetta Bignamini, Barbara Messore, Maria Cristina Lucanto, Giuseppina Leonetti, Massimo Maschio, Marco Cipolli, on behalf of the Italian Cystic Fibrosis Society (SIFC) Study Group for COVID-19

Objective: To describe the symptoms and clinical course of SARS-CoV-2 infection in patients with cystic fibrosis (CF). Methods: We carried…
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Fig 3. Heat map of phenotypes associated with COVID-19 outcomes. by Song et al., CC BY 4.0

PLOS ONE Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program
May 13, 2021 Rebecca J. Song, Yuk-Lam Ho, Petra Schubert, Yojin Park, Daniel Posner, Emily M. Lord, Lauren Costa, Hanna Gerlovin, Katherine E. Kurgansky, Tori Anglin-Foote, Scott DuVall, Jennifer E. Huffman, Saiju Pyarajan, Jean C. Beckham, Kyong-Mi Chang, Katherine P. Liao, Luc Djousse, David R. Gagnon, Stacey B. Whitbourne, Rachel Ramoni, Sumitra Muralidhar, Philip S. Tsao, Christopher J. O’Donnell, John Michael Gaziano, Juan P. Casas, Kelly Cho, on behalf of the VA Million Veteran Program COVID-19 Science Initiative

Background: The risk factors associated with the stages of Coronavirus Disease-2019 (COVID-19) disease progression are not well known. We…
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Fig 1. Projections of daily PEH isolation bed demand with 95% prediction intervals under seven intervention scenarios. by Ingle et al., CC BY 4.0

PLOS ONE Projecting COVID-19 isolation bed requirements for people experiencing homelessness
May 12, 2021 Tanvi A. Ingle, Maike Morrison, Xutong Wang, Timothy Mercer, Vella Karman, Spencer Fox, Lauren Ancel Meyers

As COVID-19 spreads across the United States, people experiencing homelessness (PEH) are among the most vulnerable to the virus. To…
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Fig 1. Epidemic curve of COVID-19 cases at the Djoungolo Hospital. by Fouda Mbarga et al., CC BY 4.0

PLOS ONE Clinical profile and factors associated with COVID-19 in Yaounde, Cameroon: A prospective cohort study
May 12, 2021 Nicole Fouda Mbarga, Emilienne Epee, Marcel Mbarga, Patrick Ouamba, Herwin Nanda, Aristide Nkengni, Joseph Guekeme, Justin Eyong, Sylvie Tossoukpe, Sauvia Noumedem Sosso, Engelbert Ngono Ngono, Lazare Mbala Ntsama, Landry Bonyomo, Patrick Tchatchoua, Noel Vogue, Steve Metomb, Franck Ale, Moussa Ousman, Dorian Job, Charlotte Moussi, Modeste Tamakloe, Jessica E. Haberer, Sylvester Ndeso Atanga, Gregory Halle-Ekane, Yap Boum II

Background: A year after the COVID-19 pandemic started, there are still few scientific reports on COVID-19 in Africa. This study explores…
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Fig 2. Lopinavir/ritonavir and hydroxychloroquine (triple therapy) are associated with an increase in the incidence of Acute Kidney Injury (AKI). by Schneider et al., CC BY 4.0

PLOS ONE Therapy with lopinavir/ritonavir and hydroxychloroquine is associated with acute kidney injury in COVID-19 patients
May 11, 2021 Johanna Schneider, Bernd Jaenigen, Dirk Wagner, Siegbert Rieg, Daniel Hornuss, Paul M. Biever, Winfried V. Kern, Gerd Walz

Background: Acute kidney injury (AKI) is an independent risk factor for mortality, which affects about 5% of hospitalized coronavirus…
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Fig 2. Raspberry Pi 4 model B hardware design. by Hosny et al., CC BY 4.0

PLOS ONE COVID-19 diagnosis from CT scans and chest X-ray images using low-cost Raspberry Pi
May 11, 2021 Khalid M. Hosny, Mohamed M. Darwish, Kenli Li, Ahmad Salah

The diagnosis of COVID-19 is of vital demand. Several studies have been conducted to decide whether the chest X-ray and computed…
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Fig 2. Antibiotic prescription variation over time. by Calderón-Parra et al., CC BY 4.0

PLOS ONE Inappropriate antibiotic use in the COVID-19 era: Factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID
May 11, 2021 Jorge Calderón-Parra, Antonio Muiño-Miguez, Alejandro D. Bendala-Estrada, Antonio Ramos-Martínez, Elena Muñez-Rubio, Eduardo Fernández Carracedo, Javier Tejada Montes, Manuel Rubio-Rivas, Francisco Arnalich-Fernandez, Jose Luis Beato Pérez, Jose Miguel García Bruñén, Esther del Corral Beamonte, Paula Maria Pesqueira Fontan, Maria del Mar Carmona, Rosa Fernández-Madera Martínez, Andrés González García, Cristina Salazar Mosteiro, Carlota Tuñón de Almeida, Julio González Moraleja, Francesco Deodati, María Dolores Martín Escalante, María Luisa Asensio Tomás, Ricardo Gómez Huelgas, José Manuel Casas Rojo, Jesús Millán Núñez-Cortés, for the SEMI-COVID-19 Network

Background: Most patients with COVID-19 receive antibiotics despite the fact that bacterial co-infections are rare. This can lead to…
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Fig 2. Locations of ICU responders. by Brewster et al., CC BY 4.0

PLOS ONE Preparation for airway management in Australia and New Zealand ICUs during the COVID -19 pandemic
May 7, 2021 David J. Brewster, Christopher P. Nickson, Steve McGloughlin, David Pilcher, Vineet V. Sarode, Jonathan J. Gatward

Background: This paper aimed to describe the airway practices of intensive care units (ICUs) in Australia and New Zealand specific to…
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Fig 3. Top row left-to-right: Confusion matrices for ai-corona, the model proposed by Zhang et al. [29], and the model proposed by Jin et al. [30] for the CC-CCI test set, respectively. by Yousefzadeh et al., CC BY 4.0

PLOS ONE ai-corona: Radiologist-assistant deep learning framework for COVID-19 diagnosis in chest CT scans
May 7, 2021 Mehdi Yousefzadeh, Parsa Esfahanian, Seyed Mohammad Sadegh Movahed, Saeid Gorgin, Dara Rahmati, Atefeh Abedini, Seyed Alireza Nadji, Sara Haseli, Mehrdad Bakhshayesh Karam, Arda Kiani, Meisam Hoseinyazdi, Jafar Roshandel, Reza Lashgari

The development of medical assisting tools based on artificial intelligence advances is essential in the global fight against COVID-19…
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Fig 1. Evolution of cumulative cases, deaths, and policy milestones in Chile and the Metropolitan Region (March-July, 2020). by Villalobos Dintrans et al., CC BY 4.0

PLOS ONE COVID-19 incidence and mortality in the Metropolitan Region, Chile: Time, space, and structural factors
May 6, 2021 Pablo Villalobos Dintrans, Claudio Castillo, Felipe de la Fuente, Matilde Maddaleno

Demographic, health, and socioeconomic factors significantly inform COVID-19 outcomes. This article analyzes the association of these…
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Fig 3. Forest plot of pooled prevalence of superinfection in patients infected with SARS-CoV-2. by Musuuza et al., CC BY 4.0

PLOS ONE Prevalence and outcomes of co-infection and superinfection with SARS-CoV-2 and other pathogens: A systematic review and meta-analysis
May 6, 2021 Jackson S. Musuuza, Lauren Watson, Vishala Parmasad, Nathan Putman-Buehler, Leslie Christensen, Nasia Safdar

Introduction: The recovery of other pathogens in patients with SARS-CoV-2 infection has been reported, either at the time of a SARS-CoV-2…
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Fig 1. Sense of preparedness to serve in COVID-19 pandemic. by Barqawi et al., CC BY 4.0

PLOS ONE Readiness of physicians and medical students to cope with the COVID-19 pandemic in the UAE
May 6, 2021 Hiba J. Barqawi, Drishti D. Kampani, Enad S. Haddad, Nora M. Al-Roub, Eman Abu-Gharbieh

Background: Coronavirus disease (COVID-19), caused by Severe Acute Respiratory Syndrome–Coronavirus 2 (SARS-CoV2), is the defining global…
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Fig 1. Correlogram figuring out the relationship between each pair of clinical or biological variables in COVID-19 patients. by Bats et al., CC BY 4.0

PLOS ONE Covichem: A biochemical severity risk score of COVID-19 upon hospital admission
May 6, 2021 Marie-Lise Bats, Benoit Rucheton, Tara Fleur, Arthur Orieux, Clément Chemin, Sébastien Rubin, Brigitte Colombies, Arnaud Desclaux, Claire Rivoisy, Etienne Mériglier, Etienne Rivière, Alexandre Boyer, Didier Gruson, Isabelle Pellegrin, Pascale Trimoulet, Isabelle Garrigue, Rana Alkouri, Charles Dupin, François Moreau-Gaudry, Aurélie Bedel, Sandrine Dabernat

Clinical and laboratory predictors of COVID-19 severity are now well described and combined to propose mortality or severity scores.…
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Fig 1. Geographic location of sample collection sites in this study. by Megasari et al., CC BY 4.0

PLOS ONE Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
May 6, 2021 Ni Luh Ayu Megasari, Takako Utsumi, Laura Navika Yamani, Juniastuti, Emily Gunawan, Koichi Furukawa, Mitsuhiro Nishimura, Maria Inge Lusida, Yasuko Mori

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic,…
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run by brett lohmeyer, CC BY 2.0

PLOS ONE The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study
May 5, 2021 Rebecca A. G. Christensen, Jasleen Arneja, Kate St. Cyr, Shelby L. Sturrock, Jennifer D. Brooks

Background: It has been suggested that cardiorespiratory fitness (CRF) may be used to identify those at greatest risk for severe COVID-19…
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Fig 2. RT-LAMP assay limit of detection. by Uribe-Alvarez et al., CC BY 4.0

PLOS ONE Low saliva pH can yield false positives results in simple RT-LAMP-based SARS-CoV-2 diagnostic tests
May 5, 2021 Cristina Uribe-Alvarez, Quynh Lam, Don A. Baldwin, Jonathan Chernoff

Diagnosis of any infectious disease is vital for opportune treatment and to prevent dissemination. RT-qPCR tests for detection of…
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Fig 1. Number of pregnant women admitted to hospital with symptomatic and asymptomatic confirmed SARS-CoV-2 infection in the UK between 1^st March and 31^{st by Vousden et al.,}CC BY 4.0

PLOS ONE The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: A national cohort study using the UK Obstetric Surveillance System (UKOSS)
May 5, 2021 Nicola Vousden, Kathryn Bunch, Edward Morris, Nigel Simpson, Christopher Gale, Patrick O’Brien, Maria Quigley, Peter Brocklehurst, Jennifer J. Kurinczuk, Marian Knight

Background: There is a lack of population level data on risk factors, incidence and impact of SARS-CoV-2 infection in pregnant women and…
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Fig 1. Schematic diagram of the seven steps of the methodological framework according to PRISMA. by Dzinamarira et al., CC BY 4.0

PLOS ONE Risk factors for COVID-19 among healthcare workers. A protocol for a systematic review and meta-analysis
May 4, 2021 Tafadzwa Dzinamarira, Malizgani Mhango, Mathias Dzobo, Bernard Ngara, Itai Chitungo, Pelagia Makanda, James Atwine, Sphamandla Josias Nkambule, Godfrey Musuka

Background: Evidence on the spectrum of risk factors for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among…
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Fig 3. Interval from initial to recurrent positive SARS-CoV-2 RT-PCR. by Peltan et al., CC BY 4.0

PLOS ONE Evaluation of potential COVID-19 recurrence in patients with late repeat positive SARS-CoV-2 testing
May 4, 2021 Ithan D. Peltan, Sarah J. Beesley, Brandon J. Webb, Bert K. Lopansri, Will Sinclair, Jason R. Jacobs, Samuel M. Brown

Background: SARS-CoV-2 reinfection and reactivation has mostly been described in case reports. We therefore investigated the epidemiology…
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Fig 5. Meta-regression by median age of patients. by Li et al., CC BY 4.0

PLOS ONE Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis
May 3, 2021 Xinyang Li, Xianrui Zhong, Yongbo Wang, Xiantao Zeng, Ting Luo, Qing Liu

Objective: We aimed to systematically identify the possible risk factors responsible for severe cases. Methods: We searched PubMed, Embase,…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Low serum albumin and the risk of hospitalization in COVID-19 infection: A retrospective case-control study
April 30, 2021 Roshan Acharya, Dilli Poudel, Aakash Patel, Evan Schultz, Michael Bourgeois, Rishi Paswan, Scott Stockholm, Macylen Batten, Smita Kafle, Amanda Atkinson, Hafiz Sarwar

Background: The data on the COVID-19 patients who were discharged to self-quarantine is lacking. Aim: The aim of the study was to…
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Fig 2. by Elhadi et al., CC BY 4.0

PLOS ONE Epidemiology, outcomes, and utilization of intensive care unit resources for critically ill COVID-19 patients in Libya: A prospective multi-center cohort study
April 30, 2021 Muhammed Elhadi, Ahmed Alsoufi, Abdurraouf Abusalama, Akram Alkaseek, Saedah Abdeewi, Mohammed Yahya, Alsnosy Mohammed, Mohammed Abdelkabir, Mohammed Huwaysh, Emad Amkhatirah, Kamel Alshorbaji, Samer Khel, Marwa Gamra, Abdulmueti Alhadi, Taha Abubaker, Mohamed Anaiba, Mohammed Elmugassabi, Muhannud Binnawara, Ala Khaled, Ahmed Zaid, Ahmed Msherghi

Background: The coronavirus disease (COVID-19) pandemic has severely affected African countries, specifically the countries, such as Libya,…
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Fig 2. Graph plotting raw Ct values (y-axis) for all 641 positive samples in the Birmingham Turnkey lab (y-axis). by Ferguson et al., CC BY 4.0

PLOS Biology Validation testing to determine the sensitivity of lateral flow testing for asymptomatic SARS-CoV-2 detection in low prevalence settings: Testing frequency and public health messaging is key
April 29, 2021 Jack Ferguson, Steven Dunn, Angus Best, Jeremy Mirza, Benita Percival, Megan Mayhew, Oliver Megram, Fiona Ashford, Thomas White, Emma Moles-Garcia, Liam Crawford, Tim Plant, Andrew Bosworth, Michael Kidd, Alex Richter, Jonathan Deeks, Alan McNally

Lateral flow devices (LFDs) are quickly being implemented for use in large-scale population surveillance programs for SARS-CoV-2 infection…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain

PLOS ONE Risk factors for COVID-19 mortality: The effect of convalescent plasma administration
April 29, 2021 Martín R. Salazar, Soledad E. González, Lorena Regairaz, Noelia S. Ferrando, Verónica V. González Martínez, Patricia M. Carrera Ramos, Laura Muñoz, Santiago A. Pesci, Juan M. Vidal, Nicolás Kreplak, Elisa Estenssoro

Background: Convalescent plasma, widely utilized in viral infections that induce neutralizing antibodies, has been proposed for COVID-19,…
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Novel Coronavirus SARS-CoV-2 Spike Protein by NIH, CC-0 Public Domain

PLOS ONE Epidemiological, clinical, and laboratory findings for patients of different age groups with confirmed coronavirus disease 2019 (COVID-19) in a hospital in Saudi Arabia
April 29, 2021 Mutasim E. Ibrahim, Obaid S. AL-Aklobi, Mosleh M. Abomughaid, Mushabab A. Al-Ghamdi

Background: Although the coronavirus disease 2019 (COVID-19) pandemic continues to rage worldwide, clinical and laboratory studies of this…
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Novel Coronavirus SARS-CoV-2 by NIH, CC-0 Public Domain

PLOS ONE Assessment of exposure risks to COVID-19 among frontline health care workers in Amhara Region, Ethiopia: A cross-sectional survey
April 29, 2021 Seyfe Asrade Atnafie, Demssie Ayalew Anteneh, Dawit Kumilachew Yimenu, Zemene Demelash Kifle

Background: The burden to fight with Corona Virus Disease-19 (COVID-19) pandemic has lied to frontline health care workers that are putting…
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Fig 3. The pooled male to female CFRR (for seven countries) by age group together with the 95% CI lower and upper limits, derived from the meta-analysis. by Green et al., CC BY 4.0

PLOS ONE Sex differences in the case-fatality rates for COVID-19—A comparison of the age-related differences and consistency over seven countries
April 29, 2021 Manfred S. Green, Dorit Nitzan, Naama Schwartz, Yaron Niv, Victoria Peer

Background: Early in the COVID-19 pandemic, it was noted that males seemed to have higher case-fatality rates than females. We examined the…
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Fig 3. Serum Krebs von den lungen (KL-6) levels in patients with abnormal CT scans at 12 weeks. by Arnold et al., CC BY 4.0

PLOS ONE Krebs von den Lungen 6 (KL-6) as a marker for disease severity and persistent radiological abnormalities following COVID-19 infection at 12 weeks
April 29, 2021 David T. Arnold, Charmaine Donald, Max Lyon, Fergus W. Hamilton, Anna J. Morley, Marie Attwood, Alexandra Dipper, Shaney L. Barratt

Introduction: Acute presentations of COVID-19 infection vary, ranging from asymptomatic carriage through to severe clinical manifestations…
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Fig 1. Age distribution of patients stratified by clinical outcome. by Salto-Alejandre et al., CC BY 4.0

PLOS ONE Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study
April 29, 2021 Sonsoles Salto-Alejandre, Silvia Jiménez-Jorge, Nuria Sabé, Antonio Ramos-Martínez, Laura Linares, Maricela Valerio, Pilar Martín-Dávila, Mario Fernández-Ruiz, María Carmen Fariñas, Marino Blanes-Juliá, Elisa Vidal, Zaira R. Palacios-Baena, Román Hernández-Gallego, Jordi Carratalá, Jorge Calderón-Parra, María Ángeles Marcos, Patricia Muñoz, Jesús Fortún-Abete, José María Aguado, Francisco Arnaiz-Revillas, Rosa Blanes-Hernández, Julián de la Torre-Cisneros, Luis E. López-Cortés, Elena García de Vinuesa-Calvo, Clara M. Rosso, Jerónimo Pachón, Javier Sánchez-Céspedes, Elisa Cordero, on behalf of The COVIDSOT Working Team

The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Two original observations concerning bacterial infections in COVID-19 patients hospitalized in intensive care units during the first wave of the epidemic in France
April 29, 2021 Camille d’Humières, Juliette Patrier, Brice Lortat-Jacob, Alexy Tran-dinh, Lotfi Chemali, Naouale Maataoui, Emilie Rondinaud, Etienne Ruppé, Charles Burdet, Stéphane Ruckly, Philippe Montravers, Jean-François Timsit, Laurence Armand-Lefevre

Among 197 COVID-19 patients hospitalized in ICU, 88 (44.7%) experienced at least one bacterial infection, with pneumonia (39.1%) and…
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Fig 2. Patients working in a vital profession (A) and in the medical sector (B) in the SARS-Cov-2 positive-tested, negative-tested, and control groups. by van der Valk et al., CC BY 4.0

PLOS ONE Case-control study of patient characteristics, knowledge of the COVID-19 disease, risk behaviour and mental state in patients visiting an emergency room with COVID-19 symptoms in the Netherlands
April 28, 2021 J. P. M. van der Valk, F. W. J. Heijboer, H. van Middendorp, A. W. M. Evers, J. C. C. M. in ‘t Veen

Background: Coronavirus disease 2019 is a serious respiratory virus pandemic. Patient characteristics, knowledge of the COVID-19 disease,…
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Fig 1. Comparison of Genalyte target-specific results with Beckman and DiaSorin results. by Ikegami et al., CC BY 4.0

PLOS ONE Target specific serologic analysis of COVID-19 convalescent plasma
April 28, 2021 Sachie Ikegami, Robert C. Benirschke, Hossein Fakhrai-Rad, Mohammad H. Motamedi, Rick Hockett, Sean David, Hong Kee Lee, Jason Kang, Thomas J. Gniadek

This study compared the performance of four serology assays for Coronavirus Disease 2019 (COVID-19) and investigated whether COVID-19…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Pathological findings in organs and tissues of patients with COVID-19: A systematic review
April 28, 2021 Sasha Peiris, Hector Mesa, Agnes Aysola, Juan Manivel, Joao Toledo, Marcio Borges-Sa, Sylvain Aldighieri, Ludovic Reveiz

Background: Coronavirus disease (COVID-19) is the pandemic caused by SARS-CoV-2 that has caused more than 2.2 million deaths worldwide. We…
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Fig 1. Daily hospitalization incidence (rate per million population per day) in the absence of vaccination for varying level of public policy response, 2020–2022. by Coudeville et al., CC BY 4.0

PLOS ONE Potential impact of introducing vaccines against COVID-19 under supply and uptake constraints in France: A modelling study
April 28, 2021 Laurent Coudeville, Ombeline Jollivet, Cedric Mahé, Sandra Chaves, Gabriela B. Gomez

Background: The accelerated vaccine development in response to the COVID-19 pandemic should lead to a vaccine being available early 2021,…
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Fig 1. Blood donor demographics of NYC metro area. by Jin et al., CC BY 4.0

PLOS ONE Seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of New York City metro blood donors using multiple SARS-CoV-2 serological assays: Implications for controlling the epidemic and “Reopening”
April 28, 2021 Daniel K. Jin, Daniel J. Nesbitt, Jenny Yang, Haidee Chen, Julie Horowitz, Marcus Jones, Rianna Vandergaast, Timothy Carey, Samantha Reiter, Stephen J. Russell, Christos Kyratsous, Andrea Hooper, Jennifer Hamilton, Manuel Ferreira, Sarah Deng, Donna Straus, Aris Baras, Christopher D. Hillyer, Larry L. Luchsinger

Projections of the stage of the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic and local, regional and national…
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thanksgiving dinner-45.jpg by barbbarbbarb, CC BY 2.0

PLOS ONE Investigation of SARS-CoV-2 infection in dogs and cats of humans diagnosed with COVID-19 in Rio de Janeiro, Brazil
April 28, 2021 Guilherme Amaral Calvet, Sandro Antonio Pereira, Maria Ogrzewalska, Alex Pauvolid-Corrêa, Paola Cristina Resende, Wagner de Souza Tassinari, Anielle de Pina Costa, Lucas Oliveira Keidel, Alice Sampaio Barreto da Rocha, Michele Fernanda Borges da Silva, Shanna Araujo dos Santos, Ana Beatriz Machado Lima, Isabella Campos Vargas de Moraes, Artur Augusto Velho Mendes Junior, Thiago das Chagas Souza, Ezequias Batista Martins, Renato Orsini Ornellas, Maria Lopes Corrêa, Isabela Maria da Silva Antonio, Lusiele Guaraldo, Fernando do Couto Motta, Patrícia Brasil, Marilda Mendonça Siqueira, Isabella Dib Ferreira Gremião, Rodrigo Caldas Menezes

Background: Infection by SARS-CoV-2 in domestic animals has been related to close contact with humans diagnosed with COVID-19. Objectives:…
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Fig 2. by Chen et al., CC BY 4.0

PLOS ONE Hypertension as a sequela in patients of SARS-CoV-2 infection
April 28, 2021 Ganxiao Chen, Xun Li, Zuojiong Gong, Hao Xia, Yao Wang, Xuefen Wang, Yan Huang, Hector Barajas-Martinez, Dan Hu

Background: COVID-19 is a respiratory infectious disease caused by SARS-CoV-2, and cardiovascular damage is commonly observed in affected…
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Fig 3. SARS-CoV-2 mutants with one or two mildly deleterious mutations are expected to exist at high numbers. by Van Egeren et al., CC BY 4.0

PLOS ONE Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
April 28, 2021 Debra Van Egeren, Alexander Novokhodko, Madison Stoddard, Uyen Tran, Bruce Zetter, Michael Rogers, Bradley L. Pentelute, Jonathan M. Carlson, Mark Hixon, Diane Joseph-McCarthy, Arijit Chakravarty

The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics…
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Fig 1. The association of inflammatory markers with death and ICU admission in men and women with COVID-19 infection. by Lau et al., CC BY 4.0

PLOS ONE Sex differences in inflammatory markers in patients hospitalized with COVID-19 infection: Insights from the MGH COVID-19 patient registry
April 28, 2021 Emily S. Lau, Jenna N. McNeill, Samantha M. Paniagua, Elizabeth E. Liu, Jessica K. Wang, Ingrid V. Bassett, Caitlin A. Selvaggi, Steven A. Lubitz, Andrea S. Foulkes, Jennifer E. Ho

Background: Men are at higher risk for serious complications related to COVID-19 infection than women. More robust immune activation in…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS ONE Willingness to vaccinate against COVID-19 among Bangladeshi adults: Understanding the strategies to optimize vaccination coverage
April 27, 2021 Minhazul Abedin, Mohammad Aminul Islam, Farah Naz Rahman, Hasan Mahmud Reza, Mohammad Zakir Hossain, Mohammad Anwar Hossain, Adittya Arefin, Ahmed Hossain

Background: Although the approved COVID-19 vaccine has been shown to be safe and effective, mass vaccination in Bangladeshi people remains…
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Novel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain

PLOS Pathogens Individuals cannot rely on COVID-19 herd immunity: Durable immunity to viral disease is limited to viruses with obligate viremic spread
April 26, 2021 Jonathan W. Yewdell

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Fig 1. Epidemiological characteristics of COVID-19 in Africa. by Lamptey et al., CC BY 4.0

PLOS Neglected Tropical Diseases Genomic and epidemiological characteristics of SARS-CoV-2 in Africa
April 26, 2021 Jones Lamptey, Favour Oluwapelumi Oyelami, Michael Owusu, Bernard Nkrumah, Paul Oluwagbenga Idowu, Enoch Appiah Adu-Gyamfi, Armin Czika, Philip El-Duah, Richmond Yeboah, Augustina Sylverken, Oluwatayo Israel Olasunkanmi, Ellis Owusu-Dabo, Christian Drosten, Yaw Adu-Sarkodie

Since late 2019, the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, has rapidly evolved to become a global pandemic.…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS Neglected Tropical Diseases Distinguishing non severe cases of dengue from COVID-19 in the context of co-epidemics: A cohort study in a SARS-CoV-2 testing center on Reunion island
April 26, 2021 Antoine Joubert, Fanny Andry, Antoine Bertolotti, Frédéric Accot, Yatrika Koumar, Florian Legrand, Patrice Poubeau, Rodolphe Manaquin, Patrick Gérardin, Cécile Levin

Background: As coronavirus 2019 (COVID-19) is spreading globally, several countries are handling dengue epidemics. As both infections are…
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Fig 1. Number of deaths in 2020 according to age class. by Costantino et al., CC BY 4.0

PLOS ONE Utility of hospitalization for elderly individuals affected by COVID-19
April 26, 2021 Giorgio Costantino, Monica Solbiati, Silvia Elli, Marco Paganuzzi, Didi Massabò, Nicola Montano, Marta Mancarella, Francesca Cortellaro, Emanuela Cataudella, Andrea Bellone, Nicolò Capsoni, Guido Bertolini, Giovanni Nattino, Giovanni Casazza

Background: During the COVID-19 pandemic, the number of individuals needing hospital admission has sometimes exceeded the availability of…
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Fig 2. Fitted logistic curves of daily COVID-19 infections for Ireland, Germany, UK, South Korea and Iceland. by Wu et al., CC BY 4.0

PLOS ONE Correlation of national and healthcare workers COVID-19 infection data; implications for large-scale viral testing programs
April 23, 2021 Dan Wu, Pól Mac Aonghusa, Donal F. O’Shea

Time analysis of the course of an infectious disease epidemic is a critical way to understand the dynamics of pathogen transmission and…
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Fig 1. by Derington et al., CC BY 4.0

PLOS ONE Angiotensin II receptor blocker or angiotensin-converting enzyme inhibitor use and COVID-19-related outcomes among US Veterans
April 23, 2021 Catherine G. Derington, Jordana B. Cohen, April F. Mohanty, Tom H. Greene, James Cook, Jian Ying, Guo Wei, Jennifer S. Herrick, Vanessa W. Stevens, Barbara E. Jones, Libo Wang, Alexander R. Zheutlin, Andrew M. South, Thomas C. Hanff, Steven M. Smith, Rhonda M. Cooper-DeHoff, Jordan B. King, G. Caleb Alexander, Dan R. Berlowitz, Faraz S. Ahmad, M. Jason Penrod, Rachel Hess, Molly B. Conroy, James C. Fang, Michael A. Rubin, Srinivasan Beddhu, Alfred K. Cheung, Weiming Xian, William S. Weintraub, Adam P. Bress

Background: Angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) may positively or negatively…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain

PLOS ONE Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review
April 22, 2021 Lemi Belay Tolu, Alex Ezeh, Garumma Tolu Feyissa

Introduction: The evidence for vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is not well…
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Novel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain