Biology & Life Sciences

PLOS Genetics Top 10%

Published October 6, 2020 Curated Collections

PLOS Genetics is home to high-quality research in Genetics and Genomics, including human studies and model organisms . Each year, we celebrate the impact our authors have had in these fields and share out the body of work that has earned the top 10% of citations. We hope you enjoy exploring this Collection.

Image Credit: image.pgen.v16.i06.g001

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2018

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10.1371/journal.pgen.1007412

PLOS Genetics Nuclear m⁶A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
May 25, 2018 Seth D. Kasowitz, Jun Ma, Stephen J. Anderson, N. Adrian Leu, Yang Xu, Brian D. Gregory, Richard M. Schultz, P. Jeremy Wang
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10.1371/journal.pgen.1007220

PLOS Genetics Potential and limits for rapid genetic adaptation to warming in a Great Barrier Reef coral
April 19, 2018 Mikhail V. Matz, Eric A. Treml, Galina V. Aglyamova, Line K. Bay
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10.1371/journal.pgen.1007144

PLOS Genetics Brassinosteroids regulate root growth by controlling reactive oxygen species homeostasis and dual effect on ethylene synthesis in Arabidopsis
January 11, 2018 Bingsheng Lv, Huiyu Tian, Feng Zhang, Jiajia Liu, Songchong Lu, Mingyi Bai, Chuanyou Li, Zhaojun Ding
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10.1371/journal.pgen.1007872

PLOS Genetics Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling
December 26, 2018 Guy Nir, Irene Farabella, Cynthia Pérez Estrada, Carl G. Ebeling, Brian J. Beliveau, Hiroshi M. Sasaki, S. Dean Lee, Son C. Nguyen, Ruth B. McCole, Shyamtanu Chattoraj, Jelena Erceg, Jumana AlHaj Abed, Nuno M. C. Martins, Huy Q. Nguyen, Mohammed A. Hannan, Sheikh Russell, Neva C. Durand, Suhas S. P. Rao, Jocelyn Y. Kishi, Paula Soler-Vila, Michele Di Pierro, José N. Onuchic, Steven P. Callahan, John M. Schreiner, Jeff A. Stuckey, Peng Yin, Erez Lieberman Aiden, Marc A. Marti-Renom, C.-ting Wu
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10.1371/journal.pgen.1007503

PLOS Genetics No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice
July 9, 2018 Vivek Iyer, Katharina Boroviak, Mark Thomas, Brendan Doe, Laura Riva, Edward Ryder, David J. Adams
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10.1371/journal.pgen.1007813

PLOS Genetics Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria
December 19, 2018 Felix Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn G. A. Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G. Uitterlinden, Verneri Anttila, Benjamin M. Neale, Marjo-Riitta Jarvelin, Bart Fauser, Irina Kowalska, Jenny A. Visser, Marianne Andersen, Ken Ong, Elisabet Stener-Victorin, David Ehrmann, Richard S. Legro, Andres Salumets, Mark I. McCarthy, Laure Morin-Papunen, Unnur Thorsteinsdottir, Kari Stefansson, the 23andMe Research Team , Unnur Styrkarsdottir, John R. B. Perry, Andrea Dunaif, Joop Laven, Steve Franks, Cecilia M. Lindgren, Corrine K. Welt
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10.1371/journal.pgen.1007369

PLOS Genetics mTOR signaling regulates central and peripheral circadian clock function
May 11, 2018 Chidambaram Ramanathan, Nimish D. Kathale, Dong Liu, Choogon Lee, David A. Freeman, John B. Hogenesch, Ruifeng Cao, Andrew C. Liu
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10.1371/journal.pgen.1007156

PLOS Genetics Regulation of circadian clock transcriptional output by CLOCK:BMAL1
January 4, 2018 Alexandra J. Trott, Jerome S. Menet
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10.1371/journal.pgen.1007155

PLOS Genetics The rate and potential relevance of new mutations in a colonizing plant lineage
February 12, 2018 Moises Exposito-Alonso, Claude Becker, Verena J. Schuenemann, Ella Reiter, Claudia Setzer, Radka Slovak, Benjamin Brachi, Jörg Hagmann, Dominik G. Grimm, Jiahui Chen, Wolfgang Busch, Joy Bergelson, Rob W. Ness, Johannes Krause, Hernán A. Burbano, Detlef Weigel
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10.1371/journal.pgen.1007544

PLOS Genetics Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins
August 9, 2018 Eilis Hannon, Olivia Knox, Karen Sugden, Joe Burrage, Chloe C. Y. Wong, Daniel W. Belsky, David L. Corcoran, Louise Arseneault, Terrie E. Moffitt, Avshalom Caspi, Jonathan Mill
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10.1371/journal.pgen.1007337

PLOS Genetics Threshold-dependent repression of SPL gene expression by miR156/miR157 controls vegetative phase change in Arabidopsis thaliana
April 19, 2018 Jia He, Mingli Xu, Matthew R. Willmann, Kevin McCormick, Tieqiang Hu, Li Yang, Colby G. Starker, Daniel F. Voytas, Blake C. Meyers, R. Scott Poethig
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10.1371/journal.pgen.1007308

PLOS Genetics Comparison of phasing strategies for whole human genomes
April 5, 2018 Yongwook Choi, Agnes P. Chan, Ewen Kirkness, Amalio Telenti, Nicholas J. Schork
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Felix M. Key et al

PLOS Genetics Human local adaptation of the TRPM8 cold receptor along a latitudinal cline
May 3, 2018 Felix M. Key, Muslihudeen A. Abdul-Aziz, Roger Mundry, Benjamin M. Peter, Aarthi Sekar, Mauro D’Amato, Megan Y. Dennis, Joshua M. Schmidt, Aida M. Andrés
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10.1371/journal.pgen.1007322

PLOS Genetics Massive lateral transfer of genes encoding plant cell wall-degrading enzymes to the mycoparasitic fungus Trichoderma from its plant-associated hosts
April 9, 2018 Irina S. Druzhinina, Komal Chenthamara, Jian Zhang, Lea Atanasova, Dongqing Yang, Youzhi Miao, Mohammad J. Rahimi, Marica Grujic, Feng Cai, Shadi Pourmehdi, Kamariah Abu Salim, Carina Pretzer, Alexey G. Kopchinskiy, Bernard Henrissat, Alan Kuo, Hope Hundley, Mei Wang, Andrea Aerts, Asaf Salamov, Anna Lipzen, Kurt LaButti, Kerrie Barry, Igor V. Grigoriev, Qirong Shen, Christian P. Kubicek
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10.1371/journal.pgen.1007363

PLOS Genetics Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome
April 26, 2018 Raffaella De Pace, Miguel Skirzewski, Markus Damme, Rafael Mattera, Jeffrey Mercurio, Arianne M. Foster, Loreto Cuitino, Michal Jarnik, Victoria Hoffmann, H. Douglas Morris, Tae-Un Han, Grazia M. S. Mancini, Andrés Buonanno, Juan S. Bonifacino
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10.1371/journal.pgen.1007359

PLOS Genetics Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion
April 25, 2018 Szabolcs Takáts, Gábor Glatz, Győző Szenci, Attila Boda, Gábor V. Horváth, Krisztina Hegedűs, Attila L. Kovács, Gábor Juhász
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10.1371/journal.pgen.1007280

PLOS Genetics POWERDRESS-mediated histone deacetylation is essential for thermomorphogenesis in Arabidopsis thaliana
March 16, 2018 Celine Tasset, Avilash Singh Yadav, Sridevi Sureshkumar, Rupali Singh, Lennard van der Woude, Maxim Nekrasov, David Tremethick, Martijn van Zanten, Sureshkumar Balasubramanian
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10.1371/journal.pgen.1007329

PLOS Genetics Insights into the genetic epidemiology of Crohn’s and rare diseases in the Ashkenazi Jewish population
May 24, 2018 Manuel A. Rivas, Brandon E. Avila, Jukka Koskela, Hailiang Huang, Christine Stevens, Matti Pirinen, Talin Haritunians, Benjamin M. Neale, Mitja Kurki, Andrea Ganna, Daniel Graham, Benjamin Glaser, Inga Peter, Gil Atzmon, Nir Barzilai, Adam P. Levine, Elena Schiff, Nikolas Pontikos, Ben Weisburd, Monkol Lek, Konrad J. Karczewski, Jonathan Bloom, Eric V. Minikel, Britt-Sabina Petersen, Laurent Beaugerie, Philippe Seksik, Jacques Cosnes, Stefan Schreiber, Bernd Bokemeyer, Johannes Bethge, International IBD Genetics Consortium , NIDDK IBD Genetics Consortium , T2D-GENES Consortium , Graham Heap, Tariq Ahmad, Vincent Plagnol, Anthony W. Segal, Stephan Targan, Dan Turner, Paivi Saavalainen, Martti Farkkila, Kimmo Kontula, Aarno Palotie, Steven R. Brant, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Rinse K. Weersma, Andre Franke, Luke Jostins, Carl A. Anderson, Jeffrey C. Barrett, Daniel G. MacArthur, Chaim Jalas, Harry Sokol, Ramnik J. Xavier, Ann Pulver, Judy H. Cho, Dermot P. B. McGovern, Mark J. Daly
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10.1371/journal.pgen.1007361

PLOS Genetics Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs
April 30, 2018 Jonas Donner, Heidi Anderson, Stephen Davison, Angela M. Hughes, Julia Bouirmane, Johan Lindqvist, Katherine M. Lytle, Balasubramanian Ganesan, Claudia Ottka, Päivi Ruotanen, Maria Kaukonen, Oliver P. Forman, Neale Fretwell, Cynthia A. Cole, Hannes Lohi
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10.1371/journal.pgen.1007341

PLOS Genetics Supervised machine learning reveals introgressed loci in the genomes of Drosophila simulans and D. sechellia
April 23, 2018 Daniel R. Schrider, Julien Ayroles, Daniel R. Matute, Andrew D. Kern
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10.1371/journal.pgen.1007291

PLOS Genetics Endocytic recycling via the TGN underlies the polarized hyphal mode of life
April 2, 2018 Miguel Hernández-González, Ignacio Bravo-Plaza, Mario Pinar, Vivian de los Ríos, Herbert N. Arst Jr., Miguel A. Peñalva
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10.1371/journal.pgen.1007393

PLOS Genetics Condensin II drives large-scale folding and spatial partitioning of interphase chromosomes in Drosophila nuclei
July 12, 2018 Leah F. Rosin, Son C. Nguyen, Eric F. Joyce
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10.1371/journal.pgen.1007802

PLOS Genetics A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability
November 29, 2018 Mahdieh Jadaliha, Omid Gholamalamdari, Wei Tang, Yang Zhang, Ana Petracovici, Qinyu Hao, Aamira Tariq, Tae Gyoon Kim, Sarah E. Holton, Deepak K. Singh, Xiao Ling Li, Susan M. Freier, Stefan Ambs, Rohit Bhargava, Ashish Lal, Supriya G. Prasanth, Jian Ma, Kannanganattu V. Prasanth
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10.1371/journal.pgen.1007161

PLOS Genetics DNA polymerase IV primarily operates outside of DNA replication forks in Escherichia coli
January 19, 2018 Sarah S. Henrikus, Elizabeth A. Wood, John P. McDonald, Michael M. Cox, Roger Woodgate, Myron F. Goodman, Antoine M. van Oijen, Andrew Robinson
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10.1371/journal.pgen.1007254

PLOS Genetics Large scale variation in the rate of germ-line de novo mutation, base composition, divergence and diversity in humans
March 28, 2018 Thomas C. A. Smith, Peter F. Arndt, Adam Eyre-Walker
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10.1371/journal.pgen.1007288

PLOS Genetics Lack of 2′-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway
March 29, 2018 Lu Han, Michael P. Guy, Yoshiko Kon, Eric M. Phizicky
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10.1371/journal.pgen.1007157

PLOS Genetics The Arabidopsis SUMO E3 ligase SIZ1 mediates the temperature dependent trade-off between plant immunity and growth
January 22, 2018 Valentin Hammoudi, Like Fokkens, Bas Beerens, Georgios Vlachakis, Sayantani Chatterjee, Manuel Arroyo-Mateos, Paul F. K. Wackers, Martijs J. Jonker, Harrold A. van den Burg
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10.1371/journal.pgen.1007580

PLOS Genetics Host genetics and the rumen microbiome jointly associate with methane emissions in dairy cows
October 12, 2018 Gareth Frank Difford, Damian Rafal Plichta, Peter Løvendahl, Jan Lassen, Samantha Joan Noel, Ole Højberg, André-Denis G. Wright, Zhigang Zhu, Lise Kristensen, Henrik Bjørn Nielsen, Bernt Guldbrandtsen, Goutam Sahana
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10.1371/journal.pgen.1007559

PLOS Genetics Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression
August 10, 2018 Rachel Kaletsky, Victoria Yao, April Williams, Alexi M. Runnels, Alicja Tadych, Shiyi Zhou, Olga G. Troyanskaya, Coleen T. Murphy
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10.1371/journal.pgen.1007317

PLOS Genetics FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination
April 2, 2018 Joiselle Blanche Fernandes, Marine Duhamel, Mathilde Seguéla-Arnaud, Nicole Froger, Chloé Girard, Sandrine Choinard, Victor Solier, Nancy De Winne, Geert De Jaeger, Kris Gevaert, Philippe Andrey, Mathilde Grelon, Raphael Guerois, Rajeev Kumar, Raphaël Mercier
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10.1371/journal.pgen.1007166

PLOS Genetics The impact of ribosomal interference, codon usage, and exit tunnel interactions on translation elongation rate variation
January 16, 2018 Khanh Dao Duc, Yun S. Song
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10.1371/journal.pgen.1007342

PLOS Genetics Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus
April 16, 2018 Laura Devaux, Dona Sleiman, Maria-Vittoria Mazzuoli, Myriam Gominet, Philippe Lanotte, Patrick Trieu-Cuot, Pierre-Alexandre Kaminski, Arnaud Firon
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10.1371/journal.pgen.1007796

PLOS Genetics Evolution at two time frames: Polymorphisms from an ancient singular divergence event fuel contemporary parallel evolution
November 13, 2018 Steven M. Van Belleghem, Carl Vangestel, Katrien De Wolf, Zoë De Corte, Markus Möst, Pasi Rastas, Luc De Meester, Frederik Hendrickx
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10.1371/journal.pgen.1007749

PLOS Genetics Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors
November 7, 2018 François Rousset, Lun Cui, Elise Siouve, Christophe Becavin, Florence Depardieu, David Bikard
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10.1371/journal.pgen.1007641

PLOS Genetics Detecting archaic introgression using an unadmixed outgroup
September 18, 2018 Laurits Skov, Ruoyun Hui, Vladimir Shchur, Asger Hobolth, Aylwyn Scally, Mikkel Heide Schierup, Richard Durbin
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10.1371/journal.pgen.1007336

PLOS Genetics Transcription factor HAT1 is a substrate of SnRK2.3 kinase and negatively regulates ABA synthesis and signaling in Arabidopsis responding to drought
April 16, 2018 Wenrong Tan, Huapeng Zhou, Ting Zheng, Yanhai Yin, Honghui Lin, Dawei Zhang
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10.1371/journal.pgen.1007767

PLOS Genetics Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin
November 20, 2018 Meet Zandawala, Maria E. Yurgel, Michael J. Texada, Sifang Liao, Kim F. Rewitz, Alex C. Keene, Dick R. Nässel
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10.1371/journal.pgen.1007374

PLOS Genetics Role of heterotrimeric Gα proteins in maize development and enhancement of agronomic traits
April 30, 2018 Qingyu Wu, Michael Regan, Hiro Furukawa, David Jackson
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10.1371/journal.pgen.1007238

PLOS Genetics EAT1 transcription factor, a non-cell-autonomous regulator of pollen production, activates meiotic small RNA biogenesis in rice anther tapetum
February 12, 2018 Seijiro Ono, Hua Liu, Katsutoshi Tsuda, Eigo Fukai, Keisuke Tanaka, Takuji Sasaki, Ken-Ichi Nonomura
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10.1371/journal.pgen.1007162

PLOS Genetics Parallel altitudinal clines reveal trends in adaptive evolution of genome size in Zea mays
May 10, 2018 Paul Bilinski, Patrice S. Albert, Jeremy J. Berg, James A. Birchler, Mark N. Grote, Anne Lorant, Juvenal Quezada, Kelly Swarts, Jinliang Yang, Jeffrey Ross-Ibarra
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10.1371/journal.pgen.1007378

PLOS Genetics LncRNA Jpx induces Xist expression in mice using both trans and cis mechanisms
May 7, 2018 Sarah Carmona, Benjamin Lin, Tristan Chou, Katti Arroyo, Sha Sun
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10.1371/journal.pgen.1007533

PLOS Genetics Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes
July 30, 2018 Fergal M. Waldron, Graham N. Stone, Darren J. Obbard
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10.1371/journal.pgen.1007574

PLOS Genetics Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant
August 3, 2018 Huong Thi Pham, Nguyen Thi Hanh Nhiep, Thu Ngoc Minh Vu, TuAnh Ngoc Huynh, Yan Zhu, Anh Le Diep Huynh, Alolika Chakrabortti, Esteban Marcellin, Raquel Lo, Christopher B. Howard, Nidhi Bansal, Joshua J. Woodward, Zhao-Xun Liang, Mark S. Turner
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10.1371/journal.pgen.1007193

PLOS Genetics MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6
January 30, 2018 Bastian Stielow, Florian Finkernagel, Thorsten Stiewe, Andrea Nist, Guntram Suske
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10.1371/journal.pgen.1007726

PLOS Genetics A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery
October 18, 2018 Patricia D. A. Rohs, Jackson Buss, Sue I. Sim, Georgia R. Squyres, Veerasak Srisuknimit, Mandy Smith, Hongbaek Cho, Megan Sjodt, Andrew C. Kruse, Ethan C. Garner, Suzanne Walker, Daniel E. Kahne, Thomas G. Bernhardt
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10.1371/journal.pgen.1007147

PLOS Genetics Filling gaps in bacterial amino acid biosynthesis pathways with high-throughput genetics
January 11, 2018 Morgan N. Price, Grant M. Zane, Jennifer V. Kuehl, Ryan A. Melnyk, Judy D. Wall, Adam M. Deutschbauer, Adam P. Arkin
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10.1371/journal.pgen.1007281

PLOS Genetics De novo and inherited private variants in MAP1B in periventricular nodular heterotopia
May 8, 2018 Erin L. Heinzen, Adam C. O'Neill, Xiaolin Zhu, Andrew S. Allen, Melanie Bahlo, Jamel Chelly, Ming Hui Chen, William B. Dobyns, Saskia Freytag, Renzo Guerrini, Richard J. Leventer, Annapurna Poduri, Stephen P. Robertson, Christopher A. Walsh, Mengqi Zhang, for the Epi4K Consortium , Epilepsy Phenome/Genome Project
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10.1371/journal.pgen.1007223

PLOS Genetics The PHD finger protein Spp1 has distinct functions in the Set1 and the meiotic DSB formation complexes
February 14, 2018 Céline Adam, Raphaël Guérois, Anna Citarella, Laura Verardi, Florine Adolphe, Claire Béneut, Vérane Sommermeyer, Claire Ramus, Jérôme Govin, Yohann Couté, Valérie Borde
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10.1371/journal.pgen.1007217

PLOS Genetics Genome-wide association across Saccharomyces cerevisiae strains reveals substantial variation in underlying gene requirements for toxin tolerance
February 23, 2018 Maria Sardi, Vaishnavi Paithane, Michael Place, De Elegant Robinson, James Hose, Dana J. Wohlbach, Audrey P. Gasch
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10.1371/journal.pgen.1007791

PLOS Genetics Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations
December 5, 2018 Farid Rajabli, Briseida E. Feliciano, Katrina Celis, Kara L. Hamilton-Nelson, Patrice L. Whitehead, Larry D. Adams, Parker L. Bussies, Clara P. Manrique, Alejandra Rodriguez, Vanessa Rodriguez, Takiyah Starks, Grace E. Byfield, Carolina B. Sierra Lopez, Jacob L. McCauley, Heriberto Acosta, Angel Chinea, Brian W. Kunkle, Christiane Reitz, Lindsay A. Farrer, Gerard D. Schellenberg, Badri N. Vardarajan, Jeffery M. Vance, Michael L. Cuccaro, Eden R. Martin, Jonathan L. Haines, Goldie S. Byrd, Gary W. Beecham, Margaret A. Pericak-Vance
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10.1371/journal.pgen.1007384

PLOS Genetics Elevated temperature increases meiotic crossover frequency via the interfering (Type I) pathway in Arabidopsis thaliana
May 17, 2018 Jennifer L. Modliszewski, Hongkuan Wang, Ashley R. Albright, Scott M. Lewis, Alexander R. Bennett, Jiyue Huang, Hong Ma, Yingxiang Wang, Gregory P. Copenhaver
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10.1371/journal.pgen.1007163

PLOS Genetics Identification of an elaborate NK-specific system regulating HLA-C expression
January 12, 2018 Hongchuan Li, Martin A. Ivarsson, Victoria E. Walker-Sperling, Jeff Subleski, Jenna K. Johnson, Paul W. Wright, Mary Carrington, Niklas K. Björkström, Daniel W. McVicar, Stephen K. Anderson
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10.1371/journal.pgen.1007376

PLOS Genetics Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment
June 20, 2018 Michael B. Burns, Emmanuel Montassier, Juan Abrahante, Sambhawa Priya, David E. Niccum, Alexander Khoruts, Timothy K. Starr, Dan Knights, Ran Blekhman
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10.1371/journal.pgen.1007183

PLOS Genetics Rewired RNAi-mediated genome surveillance in house dust mites
January 29, 2018 Mosharrof Mondal, Pavel Klimov, Alex Sutton Flynt
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10.1371/journal.pgen.1007279

PLOS Genetics Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens
May 23, 2018 Lyndal Henden, Stuart Lee, Ivo Mueller, Alyssa Barry, Melanie Bahlo
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10.1371/journal.pgen.1007357

PLOS Genetics Robustness encoded across essential and accessory replicons of the ecologically versatile bacterium Sinorhizobium meliloti
April 19, 2018 George C. diCenzo, Alex B. Benedict, Marco Fondi, Graham C. Walker, Turlough M. Finan, Alessio Mengoni, Joel S. Griffitts
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10.1371/journal.pgen.1007273

PLOS Genetics Ethylene induced plant stress tolerance by Enterobacter sp. SA187 is mediated by 2‐keto‐4‐methylthiobutyric acid production
March 19, 2018 Axel de Zélicourt, Lukas Synek, Maged M. Saad, Hanin Alzubaidy, Rewaa Jalal, Yakun Xie, Cristina Andrés-Barrao, Eleonora Rolli, Florence Guerard, Kiruthiga G. Mariappan, Ihsanullah Daur, Jean Colcombet, Moussa Benhamed, Thomas Depaepe, Dominique Van Der Straeten, Heribert Hirt
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10.1371/journal.pgen.1007601

PLOS Genetics Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain
September 27, 2018 Pradeep Suri, Melody R. Palmer, Yakov A. Tsepilov, Maxim B. Freidin, Cindy G. Boer, Michelle S. Yau, Daniel S. Evans, Andrea Gelemanovic, Traci M. Bartz, Maria Nethander, Liubov Arbeeva, Lennart Karssen, Tuhina Neogi, Archie Campbell, Dan Mellstrom, Claes Ohlsson, Lynn M. Marshall, Eric Orwoll, Andre Uitterlinden, Jerome I. Rotter, Gordan Lauc, Bruce M. Psaty, Magnus K. Karlsson, Nancy E. Lane, Gail P. Jarvik, Ozren Polasek, Marc Hochberg, Joanne M. Jordan, Joyce B. J. Van Meurs, Rebecca Jackson, Carrie M. Nielson, Braxton D. Mitchell, Blair H. Smith, Caroline Hayward, Nicholas L. Smith, Yurii S. Aulchenko, Frances M. K. Williams
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10.1371/journal.pgen.1007358

PLOS Genetics The genomic landscape at a late stage of stickleback speciation: High genomic divergence interspersed by small localized regions of introgression
May 23, 2018 Mark Ravinet, Kohta Yoshida, Shuji Shigenobu, Atsushi Toyoda, Asao Fujiyama, Jun Kitano
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10.1371/journal.pgen.1007130

PLOS Genetics Gene duplicates cause hybrid lethality between sympatric species of Mimulus
April 12, 2018 Matthew P. Zuellig, Andrea L. Sweigart
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10.1371/journal.pgen.1007467

PLOS Genetics Repeat elements organise 3D genome structure and mediate transcription in the filamentous fungus Epichloë festucae
October 24, 2018 David J. Winter, Austen R. D. Ganley, Carolyn A. Young, Ivan Liachko, Christopher L. Schardl, Pierre-Yves Dupont, Daniel Berry, Arvina Ram, Barry Scott, Murray P. Cox
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10.1371/journal.pgen.1007237

PLOS Genetics The COP9 Signalosome regulates seed germination by facilitating protein degradation of RGL2 and ABI5
February 20, 2018 Dan Jin, Ming Wu, Bosheng Li, Birte Bücker, Philipp Keil, Shaoman Zhang, Jigang Li, Dingming Kang, Jie Liu, Jie Dong, Xing Wang Deng, Vivian Irish, Ning Wei
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10.1371/journal.pgen.1007780

PLOS Genetics Replicative and non-replicative mechanisms in the formation of clustered CNVs are indicated by whole genome characterization
November 12, 2018 Lusine Nazaryan-Petersen, Jesper Eisfeldt, Maria Pettersson, Johanna Lundin, Daniel Nilsson, Josephine Wincent, Agne Lieden, Lovisa Lovmar, Jesper Ottosson, Jelena Gacic, Outi Mäkitie, Ann Nordgren, Francesco Vezzi, Valtteri Wirta, Max Käller, Tina Duelund Hjortshøj, Cathrine Jespersgaard, Rayan Houssari, Laura Pignata, Mads Bak, Niels Tommerup, Elisabeth Syk Lundberg, Zeynep Tümer, Anna Lindstrand
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10.1371/journal.pgen.1007560

PLOS Genetics Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila
August 13, 2018 Scott Barish, Sarah Nuss, Ilya Strunilin, Suyang Bao, Sayan Mukherjee, Corbin D. Jones, Pelin C. Volkan
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10.1371/journal.pgen.1007538

PLOS Genetics Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes
September 18, 2018 Jessica E. Spiewak, Emily J. Bain, Jin Liu, Kellie Kou, Samantha L. Sturiale, Larissa B. Patterson, Parham Diba, Judith S. Eisen, Ingo Braasch, Julia Ganz, David M. Parichy
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10.1371/journal.pgen.1007394

PLOS Genetics Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth
July 12, 2018 Johanna M. Huusko, Minna K. Karjalainen, Britney E. Graham, Ge Zhang, Emily G. Farrow, Neil A. Miller, Bo Jacobsson, Haley R. Eidem, Jeffrey C. Murray, Bruce Bedell, Patrick Breheny, Noah W. Brown, Frans L. Bødker, Nadia K. Litterman, Pan-Pan Jiang, Laura Russell, David A. Hinds, Youna Hu, the 23andMe Research Team , Antonis Rokas, Kari Teramo, Kaare Christensen, Scott M. Williams, Mika Rämet, Stephen F. Kingsmore, Kelli K. Ryckman, Mikko Hallman, Louis J. Muglia
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10.1371/journal.pgen.1007387

PLOS Genetics Human demographic history has amplified the effects of background selection across the genome
June 18, 2018 Raul Torres, Zachary A. Szpiech, Ryan D. Hernandez
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10.1371/journal.pgen.1007310

PLOS Genetics Effector gene birth in plant parasitic nematodes: Neofunctionalization of a housekeeping glutathione synthetase gene
April 11, 2018 Catherine J. Lilley, Abbas Maqbool, Duqing Wu, Hazijah B. Yusup, Laura M. Jones, Paul R. J. Birch, Mark J. Banfield, Peter E. Urwin, Sebastian Eves-van den Akker
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10.1371/journal.pgen.1007355

PLOS Genetics Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer
April 16, 2018 Paula Paulo, Sofia Maia, Carla Pinto, Pedro Pinto, Augusta Monteiro, Ana Peixoto, Manuel R. Teixeira
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10.1371/journal.pgen.1007159

PLOS Genetics Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide
January 22, 2018 Julienne C. Kaiser, Alyssa N. King, Jason C. Grigg, Jessica R. Sheldon, David R. Edgell, Michael E. P. Murphy, Shaun R. Brinsmade, David E. Heinrichs
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10.1371/journal.pgen.1007427

PLOS Genetics Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer’s disease
November 2, 2018 Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wuster, Manav Kapoor, Yonglian Sun, Sharookh B. Kapadia, Lino Gonzalez, Ali A. Zarrin, Alison Goate, David V. Hansen, Timothy W. Behrens, Robert R. Graham

2017

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10.1371/journal.pgen.1007039

PLOS Genetics The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito
October 4, 2017 Andrew M. Hammond, Kyros Kyrou, Marco Bruttini, Ace North, Roberto Galizi, Xenia Karlsson, Nace Kranjc, Francesco M. Carpi, Romina D’Aurizio, Andrea Crisanti, Tony Nolan
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10.1371/journal.pgen.1006796

PLOS Genetics Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations
July 20, 2017 Jackson Champer, Riona Reeves, Suh Yeon Oh, Chen Liu, Jingxian Liu, Andrew G. Clark, Philipp W. Messer
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10.1371/journal.pgen.1006810

PLOS Genetics Lokiarchaea are close relatives of Euryarchaeota, not bridging the gap between prokaryotes and eukaryotes
June 12, 2017 Violette Da Cunha, Morgan Gaia, Daniele Gadelle, Arshan Nasir, Patrick Forterre
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10.1371/journal.pgen.1006528

PLOS Genetics Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
April 27, 2017 Mariaelisa Graff, Robert A. Scott, Anne E. Justice, Kristin L. Young, Mary F. Feitosa,
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10.1371/journal.pgen.1007081

PLOS Genetics Orienting the causal relationship between imprecisely measured traits using GWAS summary data
November 17, 2017 Gibran Hemani, Kate Tilling, George Davey Smith
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10.1371/journal.pgen.1006635

PLOS Genetics Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
March 16, 2017 Lisa Krug, Nabanita Chatterjee, Rebeca Borges-Monroy, Stephen Hearn, Wen-Wei Liao, Kathleen Morrill, Lisa Prazak, Nikolay Rozhkov, Delphine Theodorou, Molly Hammell, Josh Dubnau
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10.1371/journal.pgen.1006711

PLOS Genetics Phenome-wide heritability analysis of the UK Biobank
April 7, 2017 Tian Ge, Chia-Yen Chen, Benjamin M. Neale, Mert R. Sabuncu, Jordan W. Smoller
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10.1371/journal.pgen.1006536

PLOS Genetics Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology
January 17, 2017 Kevin K. Ogden, Wenjuan Chen, Sharon A. Swanger, Miranda J. McDaniel, Linlin Z. Fan, Chun Hu, Anel Tankovic, Hirofumi Kusumoto, Gabrielle J. Kosobucki, Anthony J. Schulien, Zhuocheng Su, Joseph Pecha, Subhrajit Bhattacharya, Slavé Petrovski, Adam E. Cohen, Elias Aizenman, Stephen F. Traynelis, Hongjie Yuan
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10.1371/journal.pgen.1006832

PLOS Genetics The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses
June 12, 2017 Dieuwertje Van der Does, Freddy Boutrot, Timo Engelsdorf, Jack Rhodes, Joseph F. McKenna, Samantha Vernhettes, Iko Koevoets, Nico Tintor, Manikandan Veerabagu, Eva Miedes, Cécile Segonzac, Milena Roux, Alice S. Breda, Christian S. Hardtke, Antonio Molina, Martijn Rep, Christa Testerink, Grégory Mouille, Herman Höfte, Thorsten Hamann, Cyril Zipfel
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10.1371/journal.pgen.1006777

PLOS Genetics Hybridization and polyploidy enable genomic plasticity without sex in the most devastating plant-parasitic nematodes
June 8, 2017 Romain Blanc-Mathieu, Laetitia Perfus-Barbeoch, Jean-Marc Aury, Martine Da Rocha, Jérôme Gouzy, Erika Sallet, Cristina Martin-Jimenez, Marc Bailly-Bechet, Philippe Castagnone-Sereno, Jean-François Flot, Djampa K. Kozlowski, Julie Cazareth, Arnaud Couloux, Corinne Da Silva, Julie Guy, Yu-Jin Kim-Jo, Corinne Rancurel, Thomas Schiex, Pierre Abad, Patrick Wincker, Etienne G. J. Danchin
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10.1371/journal.pgen.1006793

PLOS Genetics MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain
May 12, 2017 Sabine Lagger, John C. Connelly, Gabriele Schweikert, Shaun Webb, Jim Selfridge, Bernard H. Ramsahoye, Miao Yu, Chuan He, Guido Sanguinetti, Lawrence C. Sowers, Malcolm D. Walkinshaw, Adrian Bird
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10.1371/journal.pgen.1006726

PLOS Genetics The bHLH transcription factor SPATULA enables cytokinin signaling, and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium
April 7, 2017 J. Irepan Reyes-Olalde, Víctor M. Zúñiga-Mayo, Joanna Serwatowska, Ricardo A. Chavez Montes, Paulina Lozano-Sotomayor, Humberto Herrera-Ubaldo, Karla L. Gonzalez-Aguilera, Patricia Ballester, Juan José Ripoll, Ignacio Ezquer, Dario Paolo, Alexander Heyl, Lucia Colombo, Martin F. Yanofsky, Cristina Ferrandiz, Nayelli Marsch-Martínez, Stefan de Folter
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10.1371/journal.pgen.1006862

PLOS Genetics Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles
June 26, 2017 James Robinson, Lisbeth A. Guethlein, Nezih Cereb, Soo Young Yang, Paul J. Norman, Steven G. E. Marsh, Peter Parham
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10.1371/journal.pgen.1006659

PLOS Genetics A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
March 8, 2017 Dirk Smith, Hannes Helgason, Patrick Sulem, Unnur Steina Bjornsdottir, Ai Ching Lim, Gardar Sveinbjornsson, Haruki Hasegawa, Michael Brown, Randal R. Ketchem, Monica Gavala, Logan Garrett, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Sigurdsson, Olafur T. Magnusson, Gudmundur I. Eyjolfsson, Isleifur Olafsson, Pall Torfi Onundarson, Olof Sigurdardottir, David Gislason, Thorarinn Gislason, Bjorn Runar Ludviksson, Dora Ludviksdottir, H. Marike Boezen, Andrea Heinzmann, Marcus Krueger, Celeste Porsbjerg, Tarunveer S. Ahluwalia, Johannes Waage, Vibeke Backer, Klaus A. Deichmann, Gerard H. Koppelman, Klaus Bønnelykke, Hans Bisgaard, Gisli Masson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, James A. Johnston, Kari Stefansson, Ingileif Jonsdottir
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10.1371/journal.pgen.1006771

PLOS Genetics Ribosomal DNA copy number loss and sequence variation in cancer
June 22, 2017 Baoshan Xu, Hua Li, John M. Perry, Vijay Pratap Singh, Jay Unruh, Zulin Yu, Musinu Zakari, William McDowell, Linheng Li, Jennifer L. Gerton
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10.1371/journal.pgen.1006613

PLOS Genetics RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides
February 9, 2017 Katharine C. Abruzzi, Abigail Zadina, Weifei Luo, Evelyn Wiyanto, Reazur Rahman, Fang Guo, Orie Shafer, Michael Rosbash
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10.1371/journal.pgen.1006919

PLOS Genetics Adaptive introgression from distant Caribbean islands contributed to the diversification of a microendemic adaptive radiation of trophic specialist pupfishes
August 10, 2017 Emilie J. Richards, Christopher H. Martin
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10.1371/journal.pgen.1006639

PLOS Genetics The highly buffered Arabidopsis immune signaling network conceals the functions of its components
May 4, 2017 Rachel A. Hillmer, Kenichi Tsuda, Ghanasyam Rallapalli, Shuta Asai, William Truman, Matthew D. Papke, Hitoshi Sakakibara, Jonathan D. G. Jones, Chad L. Myers, Fumiaki Katagiri
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10.1371/journal.pgen.1007076

PLOS Genetics The karrikin receptor KAI2 promotes drought resistance in Arabidopsis thaliana
November 13, 2017 Weiqiang Li, Kien Huu Nguyen, Ha Duc Chu, Chien Van Ha, Yasuko Watanabe, Yuriko Osakabe, Marco Antonio Leyva-González, Mayuko Sato, Kiminori Toyooka, Laura Voges, Maho Tanaka, Mohammad Golam Mostofa, Motoaki Seki, Mitsunori Seo, Shinjiro Yamaguchi, David C. Nelson, Chunjie Tian, Luis Herrera-Estrella, Lam-Son Phan Tran
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10.1371/journal.pgen.1006704

PLOS Genetics Meioc maintains an extended meiotic prophase I in mice
April 5, 2017 Y. Q. Shirleen Soh, Maria M. Mikedis, Mina Kojima, Alexander K. Godfrey, Dirk G. de Rooij, David C. Page
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10.1371/journal.pgen.1006930

PLOS Genetics Fruit weight is controlled by Cell Size Regulator encoding a novel protein that is expressed in maturing tomato fruits
August 17, 2017 Qi Mu, Zejun Huang, Manohar Chakrabarti, Eudald Illa-Berenguer, Xiaoxi Liu, Yanping Wang, Alexis Ramos, Esther van der Knaap
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10.1371/journal.pgen.1006609

PLOS Genetics GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway
February 10, 2017 Krzysztof Kiryluk, Yifu Li, Zina Moldoveanu, Hitoshi Suzuki, Colin Reily, Ping Hou, Jingyuan Xie, Nikol Mladkova, Sindhuri Prakash, Clara Fischman, Samantha Shapiro, Robert A. LeDesma, Drew Bradbury, Iuliana Ionita-Laza, Frank Eitner, Thomas Rauen, Nicolas Maillard, Francois Berthoux, Jürgen Floege, Nan Chen, Hong Zhang, Francesco Scolari, Robert J. Wyatt, Bruce A. Julian, Ali G. Gharavi, Jan Novak
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10.1371/journal.pgen.1006994

PLOS Genetics Ribosomal DNA copy number amplification and loss in human cancers is linked to tumor genetic context, nucleolus activity, and proliferation
September 7, 2017 Meng Wang, Bernardo Lemos
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10.1371/journal.pgen.1006576

PLOS Genetics Bombyx mori P-element Somatic Inhibitor (BmPSI) Is a Key Auxiliary Factor for Silkworm Male Sex Determination
January 19, 2017 Jun Xu, Shuqing Chen, Baosheng Zeng, Anthony A. James, Yongping Huang, Anjiang Tan
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10.1371/journal.pgen.1006508

PLOS Genetics Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis
February 16, 2017 Marcin J. Skwark, Nicholas J. Croucher, Santeri Puranen, Claire Chewapreecha, Maiju Pesonen, Ying Ying Xu, Paul Turner, Simon R. Harris, Stephen B. Beres, James M. Musser, Julian Parkhill, Stephen D. Bentley, Erik Aurell, Jukka Corander
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10.1371/journal.pgen.1006560

PLOS Genetics Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans
March 10, 2017 Kimberly F. McManus, Angela M. Taravella, Brenna M. Henn, Carlos D. Bustamante, Martin Sikora, Omar E. Cornejo
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10.1371/journal.pgen.1007019

PLOS Genetics Incomplete dominance of deleterious alleles contributes substantially to trait variation and heterosis in maize
September 27, 2017 Jinliang Yang, Sofiane Mezmouk, Andy Baumgarten, Edward S. Buckler, Katherine E. Guill, Michael D. McMullen, Rita H. Mumm, Jeffrey Ross-Ibarra
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10.1371/journal.pgen.1006706

PLOS Genetics Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
April 3, 2017 Lasse Folkersen, Eric Fauman, Maria Sabater-Lleal, Rona J. Strawbridge, Mattias Frånberg, Bengt Sennblad, Damiano Baldassarre, Fabrizio Veglia, Steve E. Humphries, Rainer Rauramaa, Ulf de Faire, Andries J. Smit, Philippe Giral, Sudhir Kurl, Elmo Mannarino, Stefan Enroth, Åsa Johansson, Sofia Bosdotter Enroth, Stefan Gustafsson, Lars Lind, Cecilia Lindgren, Andrew P. Morris, Vilmantas Giedraitis, Angela Silveira, Anders Franco-Cereceda, Elena Tremoli, IMPROVE study group , Ulf Gyllensten, Erik Ingelsson, Søren Brunak, Per Eriksson, Daniel Ziemek, Anders Hamsten, Anders Mälarstig
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10.1371/journal.pgen.1006601

PLOS Genetics Excess of genomic defects in a woolly mammoth on Wrangel island
March 2, 2017 Rebekah L. Rogers, Montgomery Slatkin
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10.1371/journal.pgen.1006977

PLOS Genetics Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status
September 5, 2017 Mathias Rask-Andersen, Torgny Karlsson, Weronica E. Ek, Åsa Johansson
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10.1371/journal.pgen.1006946

PLOS Genetics Plant microRNAs in larval food regulate honeybee caste development
August 31, 2017 Kegan Zhu, Minghui Liu, Zheng Fu, Zhen Zhou, Yan Kong, Hongwei Liang, Zheguang Lin, Jun Luo, Huoqing Zheng, Ping Wan, Junfeng Zhang, Ke Zen, Jiong Chen, Fuliang Hu, Chen-Yu Zhang, Jie Ren, Xi Chen
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10.1371/journal.pgen.1006997

PLOS Genetics A high resolution atlas of gene expression in the domestic sheep (Ovis aries)
September 15, 2017 Emily L. Clark, Stephen J. Bush, Mary E. B. McCulloch, Iseabail L. Farquhar, Rachel Young, Lucas Lefevre, Clare Pridans, Hiu G. Tsang, Chunlei Wu, Cyrus Afrasiabi, Mick Watson, C. Bruce Whitelaw, Tom C. Freeman, Kim M. Summers, Alan L. Archibald, David A. Hume
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10.1371/journal.pgen.1006719

PLOS Genetics Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium
April 21, 2017 Maggie C. Y. Ng, Mariaelisa Graff, Yingchang Lu, Anne E. Justice, Poorva Mudgal, Ching-Ti Liu, Kristin Young, Lisa R. Yanek, Mary F. Feitosa, Mary K. Wojczynski, Kristin Rand, Jennifer A. Brody, Brian E. Cade, Latchezar Dimitrov, Qing Duan, Xiuqing Guo, Leslie A. Lange, Michael A. Nalls, Hayrettin Okut, Salman M. Tajuddin, Bamidele O. Tayo, Sailaja Vedantam, Jonathan P. Bradfield, Guanjie Chen, Wei-Min Chen, Alessandra Chesi, Marguerite R. Irvin, Badri Padhukasahasram, Jennifer A. Smith, Wei Zheng, Matthew A. Allison, Christine B. Ambrosone, Elisa V. Bandera, Traci M. Bartz, Sonja I. Berndt, Leslie Bernstein, William J. Blot, Erwin P. Bottinger, John Carpten, Stephen J. Chanock, Yii-Der Ida Chen, David V. Conti, Richard S. Cooper, Myriam Fornage, Barry I. Freedman, Melissa Garcia, Phyllis J. Goodman, Yu-Han H. Hsu, Jennifer Hu, Chad D. Huff, Sue A. Ingles, Esther M. John, Rick Kittles, Eric Klein, Jin Li, Barbara McKnight, Uma Nayak, Barbara Nemesure, Adesola Ogunniyi, Andrew Olshan, Michael F. Press, Rebecca Rohde, Benjamin A. Rybicki, Babatunde Salako, Maureen Sanderson, Yaming Shao, David S. Siscovick, Janet L. Stanford, Victoria L. Stevens, Alex Stram, Sara S. Strom, Dhananjay Vaidya, John S. Witte, Jie Yao, Xiaofeng Zhu, Regina G. Ziegler, Alan B. Zonderman, Adebowale Adeyemo, Stefan Ambs, Mary Cushman, Jessica D. Faul, Hakon Hakonarson, Albert M. Levin, Katherine L. Nathanson, Erin B. Ware, David R. Weir, Wei Zhao, Degui Zhi, The Bone Mineral Density in Childhood Study (BMDCS) Group , Donna K. Arnett, Struan F. A. Grant, Sharon L. R. Kardia, Olufunmilayo I. Oloapde, D. C. Rao, Charles N. Rotimi, Michele M. Sale, L. Keoki Williams, Babette S. Zemel, Diane M. Becker, Ingrid B. Borecki, Michele K. Evans, Tamara B. Harris, Joel N. Hirschhorn, Yun Li, Sanjay R. Patel, Bruce M. Psaty, Jerome I. Rotter, James G. Wilson, Donald W. Bowden, L. Adrienne Cupples, Christopher A. Haiman, Ruth J. F. Loos, Kari E. North
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10.1371/journal.pgen.1006883

PLOS Genetics Systematic identification and characterization of regulatory elements derived from human endogenous retroviruses
July 12, 2017 Jumpei Ito, Ryota Sugimoto, Hirofumi Nakaoka, Shiro Yamada, Tetsuaki Kimura, Takahide Hayano, Ituro Inoue
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10.1371/journal.pgen.1006562

PLOS Genetics PRC2 Represses Hormone-Induced Somatic Embryogenesis in Vegetative Tissue of Arabidopsis thaliana
January 17, 2017 Iva Mozgová, Rafael Muñoz-Viana, Lars Hennig
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10.1371/journal.pgen.1006498

PLOS Genetics Genetic Variation in the Social Environment Contributes to Health and Disease
January 25, 2017 Amelie Baud, Megan K. Mulligan, Francesco Paolo Casale, Jesse F. Ingels, Casey J. Bohl, Jacques Callebert, Jean-Marie Launay, Jon Krohn, Andres Legarra, Robert W. Williams, Oliver Stegle
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10.1371/journal.pgen.1007105

PLOS Genetics mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay
November 21, 2017 Jennifer L. Anderson, Timothy S. Mulligan, Meng-Chieh Shen, Hui Wang, Catherine M. Scahill, Frederick J. Tan, Shao J. Du, Elisabeth M. Busch-Nentwich, Steven A. Farber
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10.1371/journal.pgen.1006962

PLOS Genetics A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer’s disease
August 14, 2017 Altea Rocchi, Soh Yamamoto, Tabitha Ting, Yuying Fan, Katherine Sadleir, Yigang Wang, Weiran Zhang, Sui Huang, Beth Levine, Robert Vassar, Congcong He
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10.1371/journal.pgen.1006563

PLOS Genetics Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing
February 6, 2017 Rui Zhang, Patricia Deng, Dionna Jacobson, Jin Billy Li
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10.1371/journal.pgen.1006728

PLOS Genetics Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations
May 12, 2017 Jingjing Liang, Thu H. Le, Digna R. Velez Edwards, Bamidele O. Tayo, Kyle J. Gaulton, Jennifer A. Smith, Yingchang Lu, Richard A. Jensen, Guanjie Chen, Lisa R. Yanek, Karen Schwander, Salman M. Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A. McKenzie, Ervin Fox, Michael A. Nalls, J. Hunter Young, Yan V. Sun, Jacqueline M. Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K. Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W. Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K. Evans, Alanna C. Morrison, Lisa W. Martin, Kerri L. Wiggins, Qin Hui, Wei Zhao, Rebecca D. Jackson, Erin B. Ware, Jessica D. Faul, Alex P. Reiner, Michael Bray, Joshua C. Denny, Thomas H. Mosley, Walter Palmas, Xiuqing Guo, George J. Papanicolaou, Alan D. Penman, Joseph F. Polak, Kenneth Rice, Ken D. Taylor, Eric Boerwinkle, Erwin P. Bottinger, Kiang Liu, Neil Risch, Steven C. Hunt, Charles Kooperberg, Alan B. Zonderman, Cathy C. Laurie, Diane M. Becker, Jianwen Cai, Ruth J. F. Loos, Bruce M. Psaty, David R. Weir, Sharon L. R. Kardia, Donna K. Arnett, Sungho Won, Todd L. Edwards, Susan Redline, Richard S. Cooper, D. C. Rao, Jerome I. Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
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10.1371/journal.pgen.1007042

PLOS Genetics Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos
October 4, 2017 Shoji Maenohara, Motoko Unoki, Hidehiro Toh, Hiroaki Ohishi, Jafar Sharif, Haruhiko Koseki, Hiroyuki Sasaki
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10.1371/journal.pgen.1006864

PLOS Genetics Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder
October 25, 2017 Tom S. Koemans, Tjitske Kleefstra, Melissa C. Chubak, Max H. Stone, Margot R. F. Reijnders, Sonja de Munnik, Marjolein H. Willemsen, Michaela Fenckova, Connie T. R. M. Stumpel, Levinus A. Bok, Margarita Sifuentes Saenz, Kyna A. Byerly, Linda B. Baughn, Alexander P. A. Stegmann, Rolph Pfundt, Huiqing Zhou, Hans van Bokhoven, Annette Schenck, Jamie M. Kramer
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10.1371/journal.pgen.1006646

PLOS Genetics Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization
March 9, 2017 Xiaoquan Wen, Roger Pique-Regi, Francesca Luca
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10.1371/journal.pgen.1006643

PLOS Genetics Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4⁺ versus CD8⁺ T cells
March 1, 2017 Silva Kasela, Kai Kisand, Liina Tserel, Epp Kaleviste, Anu Remm, Krista Fischer, Tõnu Esko, Harm-Jan Westra, Benjamin P. Fairfax, Seiko Makino, Julian C. Knight, Lude Franke, Andres Metspalu, Pärt Peterson, Lili Milani
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10.1371/journal.pgen.1006517

PLOS Genetics Evolved genetic and phenotypic differences due to mitochondrial-nuclear interactions
March 31, 2017 Tara Z. Baris, Dominique N. Wagner, David I. Dayan, Xiao Du, Pierre U. Blier, Nicolas Pichaud, Marjorie F. Oleksiak, Douglas L. Crawford
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10.1371/journal.pgen.1006846

PLOS Genetics Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis
July 17, 2017 Paula Dietrich, Irudayam Maria Johnson, Shanta Alli, Ioannis Dragatsis
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10.1371/journal.pgen.1006593

PLOS Genetics Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease
March 2, 2017 Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K. Ivanov, Jemma Gatliff, Beatriz Gomez Perez-Nievas, Hélène C. Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M. Cochemé, Jennifer Adcott, Mobina Khericha, Jorge Iván Castillo-Quan, Geoffrey Wells, Wendy Noble, Janet Thornton, Linda Partridge
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10.1371/journal.pgen.1006537

PLOS Genetics Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers
January 6, 2017 Samantha N. McNulty, Jose F. Tort, Gabriel Rinaldi, Kerstin Fischer, Bruce A. Rosa, Pablo Smircich, Santiago Fontenla, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Victoria H. Mann, Lakshmi Kammili, Patricia S. Latham, Nicolas Dell’Oca, Fernanda Dominguez, Carlos Carmona, Peter U. Fischer, Paul J. Brindley, Makedonka Mitreva
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10.1371/journal.pgen.1006956

PLOS Genetics Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries
August 21, 2017 Radha Raman Pandey, David Homolka, Kuan-Ming Chen, Ravi Sachidanandam, Marie-Odile Fauvarque, Ramesh S. Pillai
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10.1371/journal.pgen.1006739

PLOS Genetics Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations
April 19, 2017 Sofie V. Nielsen, Amelie Stein, Alexander B. Dinitzen, Elena Papaleo, Michael H. Tatham, Esben G. Poulsen, Maher M. Kassem, Lene J. Rasmussen, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
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10.1371/journal.pgen.1006916

PLOS Genetics Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies
July 17, 2017 Cameron Palmer, Itsik Pe’er
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10.1371/journal.pgen.1007040

PLOS Genetics Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States
September 28, 2017 Le Shu, Kei Hang K. Chan, Guanglin Zhang, Tianxiao Huan, Zeyneb Kurt, Yuqi Zhao, Veronica Codoni, David-Alexandre Trégouët, Cardiogenics Consortium , Jun Yang, James G. Wilson, Xi Luo, Daniel Levy, Aldons J. Lusis, Simin Liu, Xia Yang
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10.1371/journal.pgen.1006675

PLOS Genetics Evolutionary history of Tibetans inferred from whole-genome sequencing
April 27, 2017 Hao Hu, Nayia Petousi, Gustavo Glusman, Yao Yu, Ryan Bohlender, Tsewang Tashi, Jonathan M. Downie, Jared C. Roach, Amy M. Cole, Felipe R. Lorenzo, Alan R. Rogers, Mary E. Brunkow, Gianpiero Cavalleri, Leroy Hood, Sama M. Alpatty, Josef T. Prchal, Lynn B. Jorde, Peter A. Robbins, Tatum S. Simonson, Chad D. Huff
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10.1371/journal.pgen.1006594

PLOS Genetics Genetic prediction of male pattern baldness
February 14, 2017 Saskia P. Hagenaars, W. David Hill, Sarah E. Harris, Stuart J. Ritchie, Gail Davies, David C. Liewald, Catharine R. Gale, David J. Porteous, Ian J. Deary, Riccardo E. Marioni
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10.1371/journal.pgen.1006629

PLOS Genetics The Legionella pneumophila genome evolved to accommodate multiple regulatory mechanisms controlled by the CsrA-system
February 17, 2017 Tobias Sahr, Christophe Rusniok, Francis Impens, Giulia Oliva, Odile Sismeiro, Jean-Yves Coppée, Carmen Buchrieser
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10.1371/journal.pgen.1006641

PLOS Genetics Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease
March 6, 2017 J. Kenneth Baillie, Erik Arner, Carsten Daub, Michiel De Hoon, Masayoshi Itoh, Hideya Kawaji, Timo Lassmann, Piero Carninci, Alistair R. R. Forrest, Yoshihide Hayashizaki, FANTOM Consortium , Geoffrey J. Faulkner, Christine A. Wells, Michael Rehli, Paul Pavli, Kim M. Summers, David A. Hume
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10.1371/journal.pgen.1006607

PLOS Genetics The Arabidopsis bZIP11 transcription factor links low-energy signalling to auxin-mediated control of primary root growth
February 3, 2017 Christoph Weiste, Lorenzo Pedrotti, Jebasingh Selvanayagam, Prathibha Muralidhara, Christian Fröschel, Ondřej Novák, Karin Ljung, Johannes Hanson, Wolfgang Dröge-Laser
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10.1371/journal.pgen.1006554

PLOS Genetics Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes
January 25, 2017 Koji Ishikawa, Koji Makanae, Shintaro Iwasaki, Nicholas T. Ingolia, Hisao Moriya
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10.1371/journal.pgen.1006546

PLOS Genetics Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas
February 23, 2017 Kaisa Thorell, Koji Yahara, Elvire Berthenet, Daniel J. Lawson, Jane Mikhail, Ikuko Kato, Alfonso Mendez, Cosmeri Rizzato, María Mercedes Bravo, Rumiko Suzuki, Yoshio Yamaoka, Javier Torres, Samuel K. Sheppard, Daniel Falush
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10.1371/journal.pgen.1006674

PLOS Genetics Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci
April 10, 2017 Joana Rolo, Peder Worning, Jesper Boye Nielsen, Rita Sobral, Rory Bowden, Ons Bouchami, Peter Damborg, Luca Guardabassi, Vincent Perreten, Henrik Westh, Alexander Tomasz, Hermínia de Lencastre, Maria Miragaia
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10.1371/journal.pgen.1006630

PLOS Genetics Sequencing the extrachromosomal circular mobilome reveals retrotransposon activity in plants
February 17, 2017 Sophie Lanciano, Marie-Christine Carpentier, Christel Llauro, Edouard Jobet, Dagmara Robakowska-Hyzorek, Eric Lasserre, Alain Ghesquière, Olivier Panaud, Marie Mirouze
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10.1371/journal.pgen.1006667

PLOS Genetics Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans
April 4, 2017 Eve W. L. Chow, Shelly A. Clancey, R. Blake Billmyre, Anna Floyd Averette, Joshua A. Granek, Piotr Mieczkowski, Maria E. Cardenas, Joseph Heitman

2016

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10.1371/journal.pgen.1006162

PLOS Genetics Fragment Length of Circulating Tumor DNA
July 18, 2016 Hunter R. Underhill, Jacob O. Kitzman, Sabine Hellwig, Noah C. Welker, Riza Daza, Daniel N. Baker, Keith M. Gligorich, Robert C. Rostomily, Mary P. Bronner, Jay Shendure
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10.1371/journal.pgen.1005767

PLOS Genetics Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies
February 1, 2016 Xiaolei Liu, Meng Huang, Bin Fan, Edward S. Buckler, Zhiwu Zhang
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10.1371/journal.pgen.1006125

PLOS Genetics Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci
August 5, 2016 Samuel E. Jones, Jessica Tyrrell, Andrew R. Wood, Robin N. Beaumont, Katherine S. Ruth, Marcus A. Tuke, Hanieh Yaghootkar, Youna Hu, Maris Teder-Laving, Caroline Hayward, Till Roenneberg, James F. Wilson, Fabiola Del Greco, Andrew A. Hicks, Chol Shin, Chang-Ho Yun, Seung Ku Lee, Andres Metspalu, Enda M. Byrne, Philip R. Gehrman, Henning Tiemeier, Karla V. Allebrandt, Rachel M. Freathy, Anna Murray, David A. Hinds, Timothy M. Frayling, Michael N. Weedon
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10.1371/journal.pgen.1005896

PLOS Genetics Inferring Phylogenetic Networks with Maximum Pseudolikelihood under Incomplete Lineage Sorting
March 7, 2016 Claudia Solís-Lemus, Cécile Ané
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10.1371/journal.pgen.1006263

PLOS Genetics Developmental Functions of miR156-Regulated SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) Genes in Arabidopsis thaliana
August 19, 2016 Mingli Xu, Tieqiang Hu, Jianfei Zhao, Mee-Yeon Park, Keith W. Earley, Gang Wu, Li Yang, R. Scott Poethig
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10.1371/journal.pgen.1005846

PLOS Genetics Bovine Host Genetic Variation Influences Rumen Microbial Methane Production with Best Selection Criterion for Low Methane Emitting and Efficiently Feed Converting Hosts Based on Metagenomic Gene Abundance
February 18, 2016 Rainer Roehe, Richard J. Dewhurst, Carol-Anne Duthie, John A. Rooke, Nest McKain, Dave W. Ross, Jimmy J. Hyslop, Anthony Waterhouse, Tom C. Freeman, Mick Watson, R. John Wallace
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10.1371/journal.pgen.1005887

PLOS Genetics Genomics of Rapid Incipient Speciation in Sympatric Threespine Stickleback
February 29, 2016 David A. Marques, Kay Lucek, Joana I. Meier, Salome Mwaiko, Catherine E. Wagner, Laurent Excoffier, Ole Seehausen
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10.1371/journal.pgen.1005679

PLOS Genetics A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies
January 7, 2016 Masakazu Kohda, Yoshimi Tokuzawa, Yoshihito Kishita, Hiromi Nyuzuki, Yohsuke Moriyama, Yosuke Mizuno, Tomoko Hirata, Yukiko Yatsuka, Yzumi Yamashita-Sugahara, Yutaka Nakachi, Hidemasa Kato, Akihiko Okuda, Shunsuke Tamaru, Nurun Nahar Borna, Kengo Banshoya, Toshiro Aigaki, Yukiko Sato-Miyata, Kohei Ohnuma, Tsutomu Suzuki, Asuteka Nagao, Hazuki Maehata, Fumihiko Matsuda, Koichiro Higasa, Masao Nagasaki, Jun Yasuda, Masayuki Yamamoto, Takuya Fushimi, Masaru Shimura, Keiko Kaiho-Ichimoto, Hiroko Harashima, Taro Yamazaki, Masato Mori, Kei Murayama, Akira Ohtake, Yasushi Okazaki
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10.1371/journal.pgen.1005854

PLOS Genetics The Epigenomic Landscape of Prokaryotes
February 12, 2016 Matthew J. Blow, Tyson A. Clark, Chris G. Daum, Adam M. Deutschbauer, Alexey Fomenkov, Roxanne Fries, Jeff Froula, Dongwan D. Kang, Rex R. Malmstrom, Richard D. Morgan, Janos Posfai, Kanwar Singh, Axel Visel, Kelly Wetmore, Zhiying Zhao, Edward M. Rubin, Jonas Korlach, Len A. Pennacchio, Richard J. Roberts
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10.1371/journal.pgen.1006239

PLOS Genetics Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers
August 5, 2016 Seong-Keun Yoo, Seungbok Lee, Su-jin Kim, Hyeon-Gun Jee, Byoung-Ae Kim, Hyesun Cho, Young Shin Song, Sun Wook Cho, Jae-Kyung Won, Jong-Yeon Shin, Do Joon Park, Jong-Il Kim, Kyu Eun Lee, Young Joo Park, Jeong-Sun Seo
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10.1371/journal.pgen.1006280

PLOS Genetics Combined Analysis of Variation in Core, Accessory and Regulatory Genome Regions Provides a Super-Resolution View into the Evolution of Bacterial Populations
September 12, 2016 Alan McNally, Yaara Oren, Darren Kelly, Ben Pascoe, Steven Dunn, Tristan Sreecharan, Minna Vehkala, Niko Välimäki, Michael B. Prentice, Amgad Ashour, Oren Avram, Tal Pupko, Ulrich Dobrindt, Ivan Literak, Sebastian Guenther, Katharina Schaufler, Lothar H. Wieler, Zong Zhiyong, Samuel K. Sheppard, James O. McInerney, Jukka Corander
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10.1371/journal.pgen.1006340

PLOS Genetics The Strength of Selection against Neanderthal Introgression
November 8, 2016 Ivan Juric, Simon Aeschbacher, Graham Coop
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10.1371/journal.pgen.1005962

PLOS Genetics Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions
April 1, 2016 Ulrike Mäder, Pierre Nicolas, Maren Depke, Jan Pané-Farré, Michel Debarbouille, Magdalena M. van der Kooi-Pol, Cyprien Guérin, Sandra Dérozier, Aurelia Hiron, Hanne Jarmer, Aurélie Leduc, Stephan Michalik, Ewoud Reilman, Marc Schaffer, Frank Schmidt, Philippe Bessières, Philippe Noirot, Michael Hecker, Tarek Msadek, Jan Maarten van Dijl, Uwe Völker
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10.1371/journal.pgen.1006443

PLOS Genetics Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling
November 22, 2016 Janet Ugolino, Yon Ju Ji, Karen Conchina, Justin Chu, Raja Sekhar Nirujogi, Akhilesh Pandey, Nathan R. Brady, Anne Hamacher-Brady, Jiou Wang
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10.1371/journal.pgen.1006367

PLOS Genetics PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance
October 28, 2016 Soto Romuald Kiando, Nathan R. Tucker, Luis-Jaime Castro-Vega, Alexander Katz, Valentina D’Escamard, Cyrielle Tréard, Daniel Fraher, Juliette Albuisson, Daniella Kadian-Dodov, Zi Ye, Erin Austin, Min-Lee Yang, Kristina Hunker, Cristina Barlassina, Daniele Cusi, Pilar Galan, Jean-Philippe Empana, Xavier Jouven, Anne-Paule Gimenez-Roqueplo, Patrick Bruneval, Esther Soo Hyun Kim, Jeffrey W. Olin, Heather L. Gornik, Michel Azizi, Pierre-François Plouin, Patrick T. Ellinor, Iftikhar J. Kullo, David J. Milan, Santhi K. Ganesh, Pierre Boutouyrie, Jason C. Kovacic, Xavier Jeunemaitre, Nabila Bouatia-Naji
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10.1371/journal.pgen.1006146

PLOS Genetics The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo
June 30, 2016 Natalie R. Powers, Emil D. Parvanov, Christopher L. Baker, Michael Walker, Petko M. Petkov, Kenneth Paigen
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10.1371/journal.pgen.1006108

PLOS Genetics Transposable Elements versus the Fungal Genome: Impact on Whole-Genome Architecture and Transcriptional Profiles
June 13, 2016 Raúl Castanera, Leticia López-Varas, Alessandra Borgognone, Kurt LaButti, Alla Lapidus, Jeremy Schmutz, Jane Grimwood, Gúmer Pérez, Antonio G. Pisabarro, Igor V. Grigoriev, Jason E. Stajich, Lucía Ramírez
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10.1371/journal.pgen.1006111

PLOS Genetics Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes
June 15, 2016 Sebastian Lequime, Albin Fontaine, Meriadeg Ar Gouilh, Isabelle Moltini-Conclois, Louis Lambrechts
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10.1371/journal.pgen.1005954

PLOS Genetics Chromosomal-Level Assembly of the Asian Seabass Genome Using Long Sequence Reads and Multi-layered Scaffolding
April 15, 2016 Shubha Vij, Heiner Kuhl, Inna S. Kuznetsova, Aleksey Komissarov, Andrey A. Yurchenko, Peter Van Heusden, Siddharth Singh, Natascha M. Thevasagayam, Sai Rama Sridatta Prakki, Kathiresan Purushothaman, Jolly M. Saju, Junhui Jiang, Stanley Kimbung Mbandi, Mario Jonas, Amy Hin Yan Tong, Sarah Mwangi, Doreen Lau, Si Yan Ngoh, Woei Chang Liew, Xueyan Shen, Lawrence S. Hon, James P. Drake, Matthew Boitano, Richard Hall, Chen-Shan Chin, Ramkumar Lachumanan, Jonas Korlach, Vladimir Trifonov, Marsel Kabilov, Alexey Tupikin, Darrell Green, Simon Moxon, Tyler Garvin, Fritz J. Sedlazeck, Gregory W. Vurture, Gopikrishna Gopalapillai, Vinaya Kumar Katneni, Tansyn H. Noble, Vinod Scaria, Sridhar Sivasubbu, Dean R. Jerry, Stephen J. O'Brien, Michael C. Schatz, Tamás Dalmay, Stephen W. Turner, Si Lok, Alan Christoffels, László Orbán
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10.1371/journal.pgen.1005771

PLOS Genetics Arabidopsis Flower and Embryo Developmental Genes are Repressed in Seedlings by Different Combinations of Polycomb Group Proteins in Association with Distinct Sets of Cis-regulatory Elements
January 13, 2016 Hua Wang, Chunmei Liu, Jingfei Cheng, Jian Liu, Lei Zhang, Chongsheng He, Wen-Hui Shen, Hong Jin, Lin Xu, Yijing Zhang
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10.1371/journal.pgen.1006059

PLOS Genetics The Great Migration and African-American Genomic Diversity
May 27, 2016 Soheil Baharian, Maxime Barakatt, Christopher R. Gignoux, Suyash Shringarpure, Jacob Errington, William J. Blot, Carlos D. Bustamante, Eimear E. Kenny, Scott M. Williams, Melinda C. Aldrich, Simon Gravel
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10.1371/journal.pgen.1005756

PLOS Genetics Exonic Splicing Mutations Are More Prevalent than Currently Estimated and Can Be Predicted by Using In Silico Tools
January 13, 2016 Omar Soukarieh, Pascaline Gaildrat, Mohamad Hamieh, Aurélie Drouet, Stéphanie Baert-Desurmont, Thierry Frébourg, Mario Tosi, Alexandra Martins
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10.1371/journal.pgen.1005928

PLOS Genetics S/HIC: Robust Identification of Soft and Hard Sweeps Using Machine Learning
March 15, 2016 Daniel R. Schrider, Andrew D. Kern
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10.1371/journal.pgen.1005703

PLOS Genetics A Spatial Framework for Understanding Population Structure and Admixture
January 15, 2016 Gideon S. Bradburd, Peter L. Ralph, Graham M. Coop
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10.1371/journal.pgen.1005939

PLOS Genetics Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number
March 15, 2016 Manja Wachsmuth, Alexander Hübner, Mingkun Li, Burkhard Madea, Mark Stoneking
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10.1371/journal.pgen.1005877

PLOS Genetics Inferring Population Size History from Large Samples of Genome-Wide Molecular Data – An Approximate Bayesian Computation Approach
March 4, 2016 Simon Boitard, Willy Rodríguez, Flora Jay, Stefano Mona, Frédéric Austerlitz
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10.1371/journal.pgen.1005774

PLOS Genetics Adaptive Protein Evolution in Animals and the Effective Population Size Hypothesis
January 11, 2016 Nicolas Galtier
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10.1371/journal.pgen.1005778

PLOS Genetics Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution
February 18, 2016 Ryutaro Uchi, Yusuke Takahashi, Atsushi Niida, Teppei Shimamura, Hidenari Hirata, Keishi Sugimachi, Genta Sawada, Takeshi Iwaya, Junji Kurashige, Yoshiaki Shinden, Tomohiro Iguchi, Hidetoshi Eguchi, Kenichi Chiba, Yuichi Shiraishi, Genta Nagae, Kenichi Yoshida, Yasunobu Nagata, Hiroshi Haeno, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Hisae Iinuma, Shin Sasaki, Satoshi Nagayama, Kazutaka Yamada, Shinichi Yachida, Mamoru Kato, Tatsuhiro Shibata, Eiji Oki, Hiroshi Saeki, Ken Shirabe, Yoshinao Oda, Yoshihiko Maehara, Shizuo Komune, Masaki Mori, Yutaka Suzuki, Ken Yamamoto, Hiroyuki Aburatani, Seishi Ogawa, Satoru Miyano, Koshi Mimori
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10.1371/journal.pgen.1006155

PLOS Genetics Complex Ancestries of Lager-Brewing Hybrids Were Shaped by Standing Variation in the Wild Yeast Saccharomyces eubayanus
July 6, 2016 David Peris, Quinn K. Langdon, Ryan V. Moriarty, Kayla Sylvester, Martin Bontrager, Guillaume Charron, Jean-Baptiste Leducq, Christian R. Landry, Diego Libkind, Chris Todd Hittinger
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10.1371/journal.pgen.1006323

PLOS Genetics Bmp15 Is an Oocyte-Produced Signal Required for Maintenance of the Adult Female Sexual Phenotype in Zebrafish
September 19, 2016 Daniel B. Dranow, Kevin Hu, April M. Bird, S. Terese Lawry, Melissa T. Adams, Angelica Sanchez, James F. Amatruda, Bruce W. Draper
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10.1371/journal.pgen.1006149

PLOS Genetics Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology
August 25, 2016 John R. Shaffer, Ekaterina Orlova, Myoung Keun Lee, Elizabeth J. Leslie, Zachary D. Raffensperger, Carrie L. Heike, Michael L. Cunningham, Jacqueline T. Hecht, Chung How Kau, Nichole L. Nidey, Lina M. Moreno, George L. Wehby, Jeffrey C. Murray, Cecelia A. Laurie, Cathy C. Laurie, Joanne Cole, Tracey Ferrara, Stephanie Santorico, Ophir Klein, Washington Mio, Eleanor Feingold, Benedikt Hallgrimsson, Richard A. Spritz, Mary L. Marazita, Seth M. Weinberg
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10.1371/journal.pgen.1005963

PLOS Genetics De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects
April 8, 2016 James R. Priest, Kazutoyo Osoegawa, Nebil Mohammed, Vivek Nanda, Ramendra Kundu, Kathleen Schultz, Edward J. Lammer, Santhosh Girirajan, Todd Scheetz, Daryl Waggott, Francois Haddad, Sushma Reddy, Daniel Bernstein, Trudy Burns, Jeffrey D. Steimle, Xinan H. Yang, Ivan P. Moskowitz, Matthew Hurles, Richard P. Lifton, Debbie Nickerson, Michael Bamshad, Evan E. Eichler, Seema Mital, Val Sheffield, Thomas Quertermous, Bruce D. Gelb, Michael Portman, Euan A. Ashley
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10.1371/journal.pgen.1006258

PLOS Genetics The Impact of 18 Ancestral and Horizontally-Acquired Regulatory Proteins upon the Transcriptome and sRNA Landscape of Salmonella enterica serovar Typhimurium
August 26, 2016 Aoife M. Colgan, Carsten Kröger, Médéric Diard, Wolf-Dietrich Hardt, José L. Puente, Sathesh K. Sivasankaran, Karsten Hokamp, Jay C. D. Hinton
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10.1371/journal.pgen.1006135

PLOS Genetics Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction
July 14, 2016 Sara Gelino, Jessica T. Chang, Caroline Kumsta, Xingyu She, Andrew Davis, Christian Nguyen, Siler Panowski, Malene Hansen
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10.1371/journal.pgen.1005951

PLOS Genetics The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster
April 1, 2016 Chad M. Hunter, Wen Huang, Trudy F. C. Mackay, Nadia D. Singh
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10.1371/journal.pgen.1005709

PLOS Genetics Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes
February 12, 2016 Thomas Arbogast, Abdel-Mouttalib Ouagazzal, Claire Chevalier, Maksym Kopanitsa, Nurudeen Afinowi, Eugenia Migliavacca, Belinda S. Cowling, Marie-Christine Birling, Marie-France Champy, Alexandre Reymond, Yann Herault
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10.1371/journal.pgen.1005793

PLOS Genetics Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs
January 26, 2016 Courtney K. Burrows, Nicholas E. Banovich, Bryan J. Pavlovic, Kristen Patterson, Irene Gallego Romero, Jonathan K. Pritchard, Yoav Gilad
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10.1371/journal.pgen.1006421

PLOS Genetics The Genetic Architecture of Quantitative Traits Cannot Be Inferred from Variance Component Analysis
November 3, 2016 Wen Huang, Trudy F. C. Mackay
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10.1371/journal.pgen.1006157

PLOS Genetics Multispecies Outcomes of Sympatric Speciation after Admixture with the Source Population in Two Radiations of Nicaraguan Crater Lake Cichlids
June 30, 2016 Andreas F. Kautt, Gonzalo Machado-Schiaffino, Axel Meyer
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10.1371/journal.pgen.1006170

PLOS Genetics Sex-Specific Selection and Sex-Biased Gene Expression in Humans and Flies
September 22, 2016 Changde Cheng, Mark Kirkpatrick
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10.1371/journal.pgen.1006032

PLOS Genetics The Hybrid Histidine Kinase LadS Forms a Multicomponent Signal Transduction System with the GacS/GacA Two-Component System in Pseudomonas aeruginosa
May 13, 2016 Gaël Chambonnier, Lorène Roux, David Redelberger, Firas Fadel, Alain Filloux, Melissa Sivaneson, Sophie de Bentzmann, Christophe Bordi
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10.1371/journal.pgen.1006423

PLOS Genetics Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues
November 11, 2016 Heather E. Wheeler, Kaanan P. Shah, Jonathon Brenner, Tzintzuni Garcia, Keston Aquino-Michaels, GTEx Consortium , Nancy J. Cox, Dan L. Nicolae, Hae Kyung Im
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10.1371/journal.pgen.1006089

PLOS Genetics Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila
May 27, 2016 Sveta Chakrabarti, Jan Paul Dudzic, Xiaoxue Li, Esther Jeanne Collas, Jean-Phillipe Boquete, Bruno Lemaitre
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10.1371/journal.pgen.1006130

PLOS Genetics A Genomic Map of the Effects of Linked Selection in Drosophila
August 18, 2016 Eyal Elyashiv, Shmuel Sattath, Tina T. Hu, Alon Strutsovsky, Graham McVicker, Peter Andolfatto, Graham Coop, Guy Sella
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10.1371/journal.pgen.1006232

PLOS Genetics Hotair Is Dispensible for Mouse Development
December 15, 2016 Ana Rita Amândio, Anamaria Necsulea, Elisabeth Joye, Bénédicte Mascrez, Denis Duboule
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10.1371/journal.pgen.1006315

PLOS Genetics Multi-nucleotide de novo Mutations in Humans
November 15, 2016 Søren Besenbacher, Patrick Sulem, Agnar Helgason, Hannes Helgason, Helgi Kristjansson, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Olafur Th. Magnusson, Unnur Thorsteinsdottir, Gisli Masson, Augustine Kong, Daniel F. Gudbjartsson, Kari Stefansson
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10.1371/journal.pgen.1006526

PLOS Genetics DNA Methylation Signatures of the Plant Chromomethyltransferases
December 20, 2016 Quentin Gouil, David C. Baulcombe
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10.1371/journal.pgen.1006245

PLOS Genetics The Contribution of Mosaic Variants to Autism Spectrum Disorder
September 15, 2016 Donald Freed, Jonathan Pevsner
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10.1371/journal.pgen.1006386

PLOS Genetics The QTL GNP1 Encodes GA20ox1, Which Increases Grain Number and Yield by Increasing Cytokinin Activity in Rice Panicle Meristems
October 20, 2016 Yuan Wu, Yun Wang, Xue-Fei Mi, Jun-Xiang Shan, Xin-Min Li, Jian-Long Xu, Hong-Xuan Lin
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10.1371/journal.pgen.1006223

PLOS Genetics Exposure to the BPA-Substitute Bisphenol S Causes Unique Alterations of Germline Function
July 29, 2016 Yichang Chen, Le Shu, Zhiqun Qiu, Dong Yeon Lee, Sara J. Settle, Shane Que Hee, Donatello Telesca, Xia Yang, Patrick Allard
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10.1371/journal.pgen.1006141

PLOS Genetics Limited Contribution of DNA Methylation Variation to Expression Regulation in Arabidopsis thaliana
July 11, 2016 Dazhe Meng, Manu Dubin, Pei Zhang, Edward J. Osborne, Oliver Stegle, Richard M. Clark, Magnus Nordborg
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10.1371/journal.pgen.1006106

PLOS Genetics Dynamics of Chloroplast Translation during Chloroplast Differentiation in Maize
July 14, 2016 Prakitchai Chotewutmontri, Alice Barkan
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10.1371/journal.pgen.1005917

PLOS Genetics Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity
March 29, 2016 Kanae Ando, Akiko Maruko-Otake, Yosuke Ohtake, Motoki Hayashishita, Michiko Sekiya, Koichi M. Iijima
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10.1371/journal.pgen.1006427

PLOS Genetics Human Oocyte-Derived Methylation Differences Persist in the Placenta Revealing Widespread Transient Imprinting
November 11, 2016 Marta Sanchez-Delgado, Franck Court, Enrique Vidal, Jose Medrano, Ana Monteagudo-Sánchez, Alex Martin-Trujillo, Chiharu Tayama, Isabel Iglesias-Platas, Ivanela Kondova, Ronald Bontrop, Maria Eugenia Poo-Llanillo, Tomas Marques-Bonet, Kazuhiko Nakabayashi, Carlos Simón, David Monk
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10.1371/journal.pgen.1006433

PLOS Genetics The Jujube Genome Provides Insights into Genome Evolution and the Domestication of Sweetness/Acidity Taste in Fruit Trees
December 22, 2016 Jian Huang, Chunmei Zhang, Xing Zhao, Zhangjun Fei, KangKang Wan, Zhong Zhang, Xiaoming Pang, Xiao Yin, Yang Bai, Xiaoqing Sun, Lizhi Gao, Ruiqiang Li, Jinbo Zhang, Xingang Li
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10.1371/journal.pgen.1005903

PLOS Genetics AUXIN RESPONSE FACTOR 2 Intersects Hormonal Signals in the Regulation of Tomato Fruit Ripening
March 9, 2016 Dario A. Breitel, Louise Chappell-Maor, Sagit Meir, Irina Panizel, Clara Pons Puig, Yanwei Hao, Tamar Yifhar, Hagai Yasuor, Mohamed Zouine, Mondher Bouzayen, Antonio Granell Richart, Ilana Rogachev, Asaph Aharoni
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10.1371/journal.pgen.1005821

PLOS Genetics DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia
February 26, 2016 You Li, Hisato Yagi, Ezenwa Obi Onuoha, Rama Rao Damerla, Richard Francis, Yoshiyuki Furutani, Muhammad Tariq, Stephen M. King, Gregory Hendricks, Cheng Cui, Manush Saydmohammed, Dong Min Lee, Maliha Zahid, Iman Sami, Linda Leatherbury, Gregory J. Pazour, Stephanie M. Ware, Toshio Nakanishi, Elizabeth Goldmuntz, Michael Tsang, Cecilia W. Lo
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10.1371/journal.pgen.1005908

PLOS Genetics Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease
March 25, 2016 James E. Peters, Paul A. Lyons, James C. Lee, Arianne C. Richard, Mary D. Fortune, Paul J. Newcombe, Sylvia Richardson, Kenneth G. C. Smith
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10.1371/journal.pgen.1005833

PLOS Genetics Arabidopsis WRKY6 Transcription Factor Acts as a Positive Regulator of Abscisic Acid Signaling during Seed Germination and Early Seedling Development
February 1, 2016 Yun Huang, Cui-Zhu Feng, Qing Ye, Wei-Hua Wu, Yi-Fang Chen
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10.1371/journal.pgen.1006006

PLOS Genetics Bayesian Inference of Reticulate Phylogenies under the Multispecies Network Coalescent
May 4, 2016 Dingqiao Wen, Yun Yu, Luay Nakhleh
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10.1371/journal.pgen.1005824

PLOS Genetics Specific Hsp100 Chaperones Determine the Fate of the First Enzyme of the Plastidial Isoprenoid Pathway for Either Refolding or Degradation by the Stromal Clp Protease in Arabidopsis
January 27, 2016 Pablo Pulido, Ernesto Llamas, Briardo Llorente, Salvador Ventura, Louwrance P. Wright, Manuel Rodríguez-Concepción
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10.1371/journal.pgen.1006260

PLOS Genetics Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis
October 4, 2016 Martha C. Castaño-Betancourt, Dan S. Evans, Yolande F. M. Ramos, Cindy G. Boer, Sarah Metrustry, Youfang Liu, Wouter den Hollander, Jeroen van Rooij, Virginia B. Kraus, Michelle S. Yau, Braxton D. Mitchell, Kenneth Muir, Albert Hofman, Michael Doherty, Sally Doherty, Weiya Zhang, Robert Kraaij, Fernando Rivadeneira, Elizabeth Barrett-Connor, Rose A. Maciewicz, Nigel Arden, Rob G. H. H. Nelissen, Margreet Kloppenburg, Joanne M. Jordan, Michael C. Nevitt, Eline P. Slagboom, Deborah J. Hart, Floris Lafeber, Unnur Styrkarsdottir, Eleftheria Zeggini, Evangelos Evangelou, Tim D. Spector, Andre G. Uitterlinden, Nancy E. Lane, Ingrid Meulenbelt, Ana M. Valdes, Joyce B. J. van Meurs
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10.1371/journal.pgen.1006044

PLOS Genetics High-Resolution Mapping of Crossover and Non-crossover Recombination Events by Whole-Genome Re-sequencing of an Avian Pedigree
May 24, 2016 Linnéa Smeds, Carina F. Mugal, Anna Qvarnström, Hans Ellegren
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10.1371/journal.pgen.1005850

PLOS Genetics Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12
February 18, 2016 Netta Mäkinen, Mervi Aavikko, Tuomas Heikkinen, Minna Taipale, Jussi Taipale, Riitta Koivisto-Korander, Ralf Bützow, Pia Vahteristo
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10.1371/journal.pgen.1006020

PLOS Genetics The Occurrence of the Holometabolous Pupal Stage Requires the Interaction between E93, Krüppel-Homolog 1 and Broad-Complex
May 2, 2016 Enric Ureña, Silvia Chafino, Cristina Manjón, Xavier Franch-Marro, David Martín

2015

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10.1371/journal.pgen.1004982

PLOS Genetics Genomic Selection and Association Mapping in Rice (Oryza sativa): Effect of Trait Genetic Architecture, Training Population Composition, Marker Number and Statistical Model on Accuracy of Rice Genomic Selection in Elite, Tropical Rice Breeding Lines
February 17, 2015 Jennifer Spindel, Hasina Begum, Deniz Akdemir, Parminder Virk, Bertrand Collard, Edilberto Redoña, Gary Atlin, Jean-Luc Jannink, Susan R. McCouch
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10.1371/journal.pgen.1005004

PLOS Genetics Recent Selective Sweeps in North American Drosophila melanogaster Show Signatures of Soft Sweeps
February 23, 2015 Nandita R. Garud, Philipp W. Messer, Erkan O. Buzbas, Dmitri A. Petrov
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10.1371/journal.pgen.1005241

PLOS Genetics Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential
June 3, 2015 Elpida Fragouli, Katharina Spath, Samer Alfarawati, Fiona Kaper, Andrew Craig, Claude-Edouard Michel, Felix Kokocinski, Jacques Cohen, Santiago Munne, Dagan Wells
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10.1371/journal.pgen.1004915

PLOS Genetics Transposable Elements Contribute to Activation of Maize Genes in Response to Abiotic Stress
January 8, 2015 Irina Makarevitch, Amanda J. Waters, Patrick T. West, Michelle Stitzer, Candice N. Hirsch, Jeffrey Ross-Ibarra, Nathan M. Springer
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10.1371/journal.pgen.1005378

PLOS Genetics The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
October 1, 2015 Thomas W. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata, Mary F. Feitosa, Su Chu, Jacek Czajkowski, Tõnu Esko, Tove Fall, Tuomas O. Kilpeläinen, Yingchang Lu, Reedik Mägi, Evelin Mihailov, Tune H. Pers, Sina Rüeger, Alexander Teumer, Georg B. Ehret, Teresa Ferreira, Nancy L. Heard-Costa, Juha Karjalainen, Vasiliki Lagou, Anubha Mahajan, Michael D. Neinast, Inga Prokopenko, Jeannette Simino, Tanya M. Teslovich, Rick Jansen, Harm-Jan Westra, Charles C. White, Devin Absher, Tarunveer S. Ahluwalia, Shafqat Ahmad, Eva Albrecht, Alexessander Couto Alves, Jennifer L. Bragg-Gresham, Anton J. M. de Craen, Joshua C. Bis, Amélie Bonnefond, Gabrielle Boucher, Gemma Cadby, Yu-Ching Cheng, Charleston W. K. Chiang, Graciela Delgado, Ayse Demirkan, Nicole Dueker, Niina Eklund, Gudny Eiriksdottir, Joel Eriksson, Bjarke Feenstra, Krista Fischer, Francesca Frau, Tessel E. Galesloot, Frank Geller, Anuj Goel, Mathias Gorski, Tanja B. Grammer, Stefan Gustafsson, Saskia Haitjema, Jouke-Jan Hottenga, Jennifer E. Huffman, Anne U. Jackson, Kevin B. Jacobs, Åsa Johansson, Marika Kaakinen, Marcus E. Kleber, Jari Lahti, Irene Mateo Leach, Benjamin Lehne, Youfang Liu, Ken Sin Lo, Mattias Lorentzon, Jian'an Luan, Pamela A. F. Madden, Massimo Mangino, Barbara McKnight, Carolina Medina-Gomez, Keri L. Monda, May E. Montasser, Gabriele Müller, Martina Müller-Nurasyid, Ilja M. Nolte, Kalliope Panoutsopoulou, Laura Pascoe, Lavinia Paternoster, Nigel W. Rayner, Frida Renström, Federica Rizzi, Lynda M. Rose, Kathy A. Ryan, Perttu Salo, Serena Sanna, Hubert Scharnagl, Jianxin Shi, Albert Vernon Smith, Lorraine Southam, Alena Stančáková, Valgerdur Steinthorsdottir, Rona J. Strawbridge, Yun Ju Sung, Ioanna Tachmazidou, Toshiko Tanaka, Gudmar Thorleifsson, Stella Trompet, Natalia Pervjakova, Jonathan P. Tyrer, Liesbeth Vandenput, Sander W van der Laan, Nathalie van der Velde, Jessica van Setten, Jana V. van Vliet-Ostaptchouk, Niek Verweij, Efthymia Vlachopoulou, Lindsay L. Waite, Sophie R. Wang, Zhaoming Wang, Sarah H. Wild, Christina Willenborg, James F. Wilson, Andrew Wong, Jian Yang, Loïc Yengo, Laura M. Yerges-Armstrong, Lei Yu, Weihua Zhang, Jing Hua Zhao, Ehm A. Andersson, Stephan J. L. Bakker, Damiano Baldassarre, Karina Banasik, Matteo Barcella, Cristina Barlassina, Claire Bellis, Paola Benaglio, John Blangero, Matthias Blüher, Fabrice Bonnet, Lori L. Bonnycastle, Heather A. Boyd, Marcel Bruinenberg, Aron S Buchman, Harry Campbell, Yii-Der Ida Chen, Peter S. Chines, Simone Claudi-Boehm, John Cole, Francis S. Collins, Eco J. C. de Geus, Lisette C. P. G. M. de Groot, Maria Dimitriou, Jubao Duan, Stefan Enroth, Elodie Eury, Aliki-Eleni Farmaki, Nita G. Forouhi, Nele Friedrich, Pablo V. Gejman, Bruna Gigante, Nicola Glorioso, Alan S. Go, Omri Gottesman, Jürgen Gräßler, Harald Grallert, Niels Grarup, Yu-Mei Gu, Linda Broer, Annelies C. Ham, Torben Hansen, Tamara B. Harris, Catharina A. Hartman, Maija Hassinen, Nicholas Hastie, Andrew T. Hattersley, Andrew C. Heath, Anjali K. Henders, Dena Hernandez, Hans Hillege, Oddgeir Holmen, Kees G Hovingh, Jennie Hui, Lise L. Husemoen, Nina Hutri-Kähönen, Pirro G. Hysi, Thomas Illig, Philip L. De Jager, Shapour Jalilzadeh, Torben Jørgensen, J. Wouter Jukema, Markus Juonala, Stavroula Kanoni, Maria Karaleftheri, Kay Tee Khaw, Leena Kinnunen, Steven J. Kittner, Wolfgang Koenig, Ivana Kolcic, Peter Kovacs, Nikolaj T. Krarup, Wolfgang Kratzer, Janine Krüger, Diana Kuh, Meena Kumari, Theodosios Kyriakou, Claudia Langenberg, Lars Lannfelt, Chiara Lanzani, Vaneet Lotay, Lenore J. Launer, Karin Leander, Jaana Lindström, Allan Linneberg, Yan-Ping Liu, Stéphane Lobbens, Robert Luben, Valeriya Lyssenko, Satu Männistö, Patrik K. Magnusson, Wendy L. McArdle, Cristina Menni, Sigrun Merger, Lili Milani, Grant W. Montgomery, Andrew P. Morris, Narisu Narisu, Mari Nelis, Ken K. Ong, Aarno Palotie, Louis Pérusse, Irene Pichler, Maria G. Pilia, Anneli Pouta, Myriam Rheinberger, Rasmus Ribel-Madsen, Marcus Richards, Kenneth M. Rice, Treva K. Rice, Carlo Rivolta, Veikko Salomaa, Alan R. Sanders, Mark A. Sarzynski, Salome Scholtens, Robert A. Scott, William R. Scott, Sylvain Sebert, Sebanti Sengupta, Bengt Sennblad, Thomas Seufferlein, Angela Silveira, P. Eline Slagboom, Jan H. Smit, Thomas H. Sparsø, Kathleen Stirrups, Ronald P. Stolk, Heather M. Stringham, Morris A Swertz, Amy J. Swift, Ann-Christine Syvänen, Sian-Tsung Tan, Barbara Thorand, Anke Tönjes, Angelo Tremblay, Emmanouil Tsafantakis, Peter J. van der Most, Uwe Völker, Marie-Claude Vohl, Judith M. Vonk, Melanie Waldenberger, Ryan W. Walker, Roman Wennauer, Elisabeth Widén, Gonneke Willemsen, Tom Wilsgaard, Alan F. Wright, M. Carola Zillikens, Suzanne C. van Dijk, Natasja M. van Schoor, Folkert W. Asselbergs, Paul I. W. de Bakker, Jacques S. Beckmann, John Beilby, David A. Bennett, Richard N. Bergman, Sven Bergmann, Carsten A. Böger, Bernhard O. Boehm, Eric Boerwinkle, Dorret I. Boomsma, Stefan R. Bornstein, Erwin P. Bottinger, Claude Bouchard, John C. Chambers, Stephen J. Chanock, Daniel I. Chasman, Francesco Cucca, Daniele Cusi, George Dedoussis, Jeanette Erdmann, Johan G. Eriksson, Denis A. Evans, Ulf de Faire, Martin Farrall, Luigi Ferrucci, Ian Ford, Lude Franke, Paul W. Franks, Philippe Froguel, Ron T. Gansevoort, Christian Gieger, Henrik Grönberg, Vilmundur Gudnason, Ulf Gyllensten, Per Hall, Anders Hamsten, Pim van der Harst, Caroline Hayward, Markku Heliövaara, Christian Hengstenberg, Andrew A Hicks, Aroon Hingorani, Albert Hofman, Frank Hu, Heikki V. Huikuri, Kristian Hveem, Alan L. James, Joanne M. Jordan, Antti Jula, Mika Kähönen, Eero Kajantie, Sekar Kathiresan, Lambertus A. L. M. Kiemeney, Mika Kivimaki, Paul B. Knekt, Heikki A. Koistinen, Jaspal S. Kooner, Seppo Koskinen, Johanna Kuusisto, Winfried Maerz, Nicholas G Martin, Markku Laakso, Timo A. Lakka, Terho Lehtimäki, Guillaume Lettre, Douglas F. Levinson, Lars Lind, Marja-Liisa Lokki, Pekka Mäntyselkä, Mads Melbye, Andres Metspalu, Braxton D. Mitchell, Frans L. Moll, Jeffrey C. Murray, Arthur W. Musk, Markku S. Nieminen, Inger Njølstad, Claes Ohlsson, Albertine J. Oldehinkel, Ben A. Oostra, Lyle J Palmer, James S. Pankow, Gerard Pasterkamp, Nancy L. Pedersen, Oluf Pedersen, Brenda W. Penninx, Markus Perola, Annette Peters, Ozren Polašek, Peter P. Pramstaller, Bruce M. Psaty, Lu Qi, Thomas Quertermous, Olli T. Raitakari, Tuomo Rankinen, Rainer Rauramaa, Paul M. Ridker, John D. Rioux, Fernando Rivadeneira, Jerome I. Rotter, Igor Rudan, Hester M. den Ruijter, Juha Saltevo, Naveed Sattar, Heribert Schunkert, Peter E. H. Schwarz, Alan R. Shuldiner, Juha Sinisalo, Harold Snieder, Thorkild I. A. Sørensen, Tim D. Spector, Jan A. Staessen, Bandinelli Stefania, Unnur Thorsteinsdottir, Michael Stumvoll, Jean-Claude Tardif, Elena Tremoli, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, André L. M. Verbeek, Sita H. Vermeulen, Jorma S. Viikari, Veronique Vitart, Henry Völzke, Peter Vollenweider, Gérard Waeber, Mark Walker, Henri Wallaschofski, Nicholas J. Wareham, Hugh Watkins, Eleftheria Zeggini, CHARGE Consortium , DIAGRAM Consortium , GLGC Consortium , Global-BPGen Consortium , ICBP Consortium , MAGIC Consortium , Aravinda Chakravarti, Deborah J. Clegg, L. Adrienne Cupples, Penny Gordon-Larsen, Cashell E. Jaquish, D. C. Rao, Goncalo R. Abecasis, Themistocles L. Assimes, Inês Barroso, Sonja I. Berndt, Michael Boehnke, Panos Deloukas, Caroline S. Fox, Leif C. Groop, David J. Hunter, Erik Ingelsson, Robert C. Kaplan, Mark I. McCarthy, Karen L. Mohlke, Jeffrey R. O'Connell, David Schlessinger, David P. Strachan, Kari Stefansson, Cornelia M. van Duijn, Joel N. Hirschhorn, Cecilia M. Lindgren, Iris M. Heid, Kari E. North, Ingrid B. Borecki, Zoltán Kutalik, Ruth J. F. Loos
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10.1371/journal.pgen.1005118

PLOS Genetics Genome Sequencing of the Perciform Fish Larimichthys crocea Provides Insights into Molecular and Genetic Mechanisms of Stress Adaptation
April 2, 2015 Jingqun Ao, Yinnan Mu, Li-Xin Xiang, DingDing Fan, MingJi Feng, Shicui Zhang, Qiong Shi, Lv-Yun Zhu, Ting Li, Yang Ding, Li Nie, Qiuhua Li, Wei-ren Dong, Liang Jiang, Bing Sun, XinHui Zhang, Mingyu Li, Hai-Qi Zhang, ShangBo Xie, YaBing Zhu, XuanTing Jiang, Xianhui Wang, Pengfei Mu, Wei Chen, Zhen Yue, Zhuo Wang, Jun Wang, Jian-Zhong Shao, Xinhua Chen
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10.1371/journal.pgen.1005465

PLOS Genetics YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers
August 21, 2015 Claudia Stein, Anaïs Flore Bardet, Guglielmo Roma, Sebastian Bergling, Ieuan Clay, Alexandra Ruchti, Claudia Agarinis, Tobias Schmelzle, Tewis Bouwmeester, Dirk Schübeler, Andreas Bauer
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10.1371/journal.pgen.1005674

PLOS Genetics The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
November 19, 2015 María L. García-Rubio, Carmen Pérez-Calero, Sonia I. Barroso, Emanuela Tumini, Emilia Herrera-Moyano, Iván V. Rosado, Andrés Aguilera
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10.1371/journal.pgen.1004969

PLOS Genetics Simultaneous Discovery, Estimation and Prediction Analysis of Complex Traits Using a Bayesian Mixture Model
April 7, 2015 Gerhard Moser, Sang Hong Lee, Ben J. Hayes, Michael E. Goddard, Naomi R. Wray, Peter M. Visscher
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10.1371/journal.pgen.1005048

PLOS Genetics Genomic Heritability: What Is It?
May 5, 2015 Gustavo de los Campos, Daniel Sorensen, Daniel Gianola
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10.1371/journal.pgen.1004987

PLOS Genetics Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates
February 27, 2015 Junghyun Lim, M. Lenard Lachenmayer, Shuai Wu, Wenchao Liu, Mondira Kundu, Rong Wang, Masaaki Komatsu, Young J. Oh, Yanxiang Zhao, Zhenyu Yue
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10.1371/journal.pgen.1005678

PLOS Genetics A Tandem Duplicate of Anti-Müllerian Hormone with a Missense SNP on the Y Chromosome Is Essential for Male Sex Determination in Nile Tilapia, Oreochromis niloticus
November 20, 2015 Minghui Li, Yunlv Sun, Jiue Zhao, Hongjuan Shi, Sheng Zeng, Kai Ye, Dongneng Jiang, Linyan Zhou, Lina Sun, Wenjing Tao, Yoshitaka Nagahama, Thomas D. Kocher, Deshou Wang
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10.1371/journal.pgen.1005732

PLOS Genetics Understanding Biases in Ribosome Profiling Experiments Reveals Signatures of Translation Dynamics in Yeast
December 11, 2015 Jeffrey A. Hussmann, Stephanie Patchett, Arlen Johnson, Sara Sawyer, William H. Press
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10.1371/journal.pgen.1004958

PLOS Genetics Tissue-Specific Effects of Genetic and Epigenetic Variation on Gene Regulation and Splicing
January 29, 2015 Maria Gutierrez-Arcelus, Halit Ongen, Tuuli Lappalainen, Stephen B. Montgomery, Alfonso Buil, Alisa Yurovsky, Julien Bryois, Ismael Padioleau, Luciana Romano, Alexandra Planchon, Emilie Falconnet, Deborah Bielser, Maryline Gagnebin, Thomas Giger, Christelle Borel, Audrey Letourneau, Periklis Makrythanasis, Michel Guipponi, Corinne Gehrig, Stylianos E. Antonarakis, Emmanouil T. Dermitzakis
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10.1371/journal.pgen.1005166

PLOS Genetics Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation
April 23, 2015 Wencheng Li, Bei You, Mainul Hoque, Dinghai Zheng, Wenting Luo, Zhe Ji, Ji Yeon Park, Samuel I. Gunderson, Auinash Kalsotra, James L. Manley, Bin Tian
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10.1371/journal.pgen.1005399

PLOS Genetics EIN3 and ORE1 Accelerate Degreening during Ethylene-Mediated Leaf Senescence by Directly Activating Chlorophyll Catabolic Genes in Arabidopsis
July 28, 2015 Kai Qiu, Zhongpeng Li, Zhen Yang, Junyi Chen, Shouxin Wu, Xiaoyu Zhu, Shan Gao, Jiong Gao, Guodong Ren, Benke Kuai, Xin Zhou
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10.1371/journal.pgen.1005413

PLOS Genetics A Year of Infection in the Intensive Care Unit: Prospective Whole Genome Sequencing of Bacterial Clinical Isolates Reveals Cryptic Transmissions and Novel Microbiota
July 31, 2015 David J. Roach, Joshua N. Burton, Choli Lee, Bethany Stackhouse, Susan M. Butler-Wu, Brad T. Cookson, Jay Shendure, Stephen J. Salipante
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10.1371/journal.pgen.1005079

PLOS Genetics Escape from X Inactivation Varies in Mouse Tissues
March 18, 2015 Joel B. Berletch, Wenxiu Ma, Fan Yang, Jay Shendure, William S. Noble, Christine M. Disteche, Xinxian Deng
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10.1371/journal.pgen.1005124

PLOS Genetics MAPK Signaling Pathway Alters Expression of Midgut ALP and ABCC Genes and Causes Resistance to Bacillus thuringiensis Cry1Ac Toxin in Diamondback Moth
April 13, 2015 Zhaojiang Guo, Shi Kang, Defeng Chen, Qingjun Wu, Shaoli Wang, Wen Xie, Xun Zhu, Simon W. Baxter, Xuguo Zhou, Juan Luis Jurat-Fuentes, Youjun Zhang
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10.1371/journal.pgen.1005637

PLOS Genetics Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing
November 5, 2015 Magdalena E. Tyburczy, Kira A. Dies, Jennifer Glass, Susana Camposano, Yvonne Chekaluk, Aaron R. Thorner, Ling Lin, Darcy Krueger, David N. Franz, Elizabeth A. Thiele, Mustafa Sahin, David J. Kwiatkowski
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10.1371/journal.pgen.1005658

PLOS Genetics Variation in Rural African Gut Microbiota Is Strongly Correlated with Colonization by Entamoeba and Subsistence
November 30, 2015 Elise R. Morton, Joshua Lynch, Alain Froment, Sophie Lafosse, Evelyne Heyer, Molly Przeworski, Ran Blekhman, Laure Ségurel
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10.1371/journal.pgen.1005394

PLOS Genetics Genetic Evidence for Function of the bHLH-PAS Protein Gce/Met As a Juvenile Hormone Receptor
July 10, 2015 Marek Jindra, Mirka Uhlirova, Jean-Philippe Charles, Vlastimil Smykal, Ronald J. Hill
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10.1371/journal.pgen.1004941

PLOS Genetics GC-Content Evolution in Bacterial Genomes: The Biased Gene Conversion Hypothesis Expands
February 6, 2015 Florent Lassalle, Séverine Périan, Thomas Bataillon, Xavier Nesme, Laurent Duret, Vincent Daubin
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10.1371/journal.pgen.1004972

PLOS Genetics Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan
February 11, 2015 Claire E. Schaar, Dylan J. Dues, Katie K. Spielbauer, Emily Machiela, Jason F. Cooper, Megan Senchuk, Siegfried Hekimi, Jeremy M. Van Raamsdonk
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10.1371/journal.pgen.1005694

PLOS Genetics Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors
December 1, 2015 Martijn van de Bunt, Jocelyn E. Manning Fox, Xiaoqing Dai, Amy Barrett, Caleb Grey, Lei Li, Amanda J. Bennett, Paul R. Johnson, Raymond V. Rajotte, Kyle J. Gaulton, Emmanouil T. Dermitzakis, Patrick E. MacDonald, Mark I. McCarthy, Anna L. Gloyn
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10.1371/journal.pgen.1005595

PLOS Genetics ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration
October 23, 2015 Paula Santabárbara-Ruiz, Mireya López-Santillán, Irene Martínez-Rodríguez, Anahí Binagui-Casas, Lídia Pérez, Marco Milán, Montserrat Corominas, Florenci Serras
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10.1371/journal.pgen.1005387

PLOS Genetics Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis
November 5, 2015 Li Ma, Jeffrey R. O'Connell, Paul M. VanRaden, Botong Shen, Abinash Padhi, Chuanyu Sun, Derek M. Bickhart, John B. Cole, Daniel J. Null, George E. Liu, Yang Da, George R. Wiggans
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10.1371/journal.pgen.1005534

PLOS Genetics Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transporter Subfamily A Protein
November 19, 2015 Wee Tek Tay, Rod J. Mahon, David G. Heckel, Thomas K. Walsh, Sharon Downes, William J. James, Sui-Fai Lee, Annette Reineke, Adam K. Williams, Karl H. J. Gordon
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10.1371/journal.pgen.1005206

PLOS Genetics Accounting for Experimental Noise Reveals That mRNA Levels, Amplified by Post-Transcriptional Processes, Largely Determine Steady-State Protein Levels in Yeast
May 7, 2015 Gábor Csárdi, Alexander Franks, David S. Choi, Edoardo M. Airoldi, D. Allan Drummond
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10.1371/journal.pgen.1005613

PLOS Genetics Secondary Structure across the Bacterial Transcriptome Reveals Versatile Roles in mRNA Regulation and Function
October 23, 2015 Cristian Del Campo, Alexander Bartholomäus, Ivan Fedyunin, Zoya Ignatova
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10.1371/journal.pgen.1005614

PLOS Genetics Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin
November 5, 2015 Guangxi Wu, He Zhao, Chenhao Li, Menaka Priyadarsani Rajapakse, Wing Cheong Wong, Jun Xu, Charles W. Saunders, Nancy L. Reeder, Raymond A. Reilman, Annika Scheynius, Sheng Sun, Blake Robert Billmyre, Wenjun Li, Anna Floyd Averette, Piotr Mieczkowski, Joseph Heitman, Bart Theelen, Markus S. Schröder, Paola Florez De Sessions, Geraldine Butler, Sebastian Maurer-Stroh, Teun Boekhout, Niranjan Nagarajan, Thomas L. Dawson Jr.
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10.1371/journal.pgen.1005602

PLOS Genetics Genomic Insights into the Ancestry and Demographic History of South America
December 4, 2015 Julian R. Homburger, Andrés Moreno-Estrada, Christopher R. Gignoux, Dominic Nelson, Elena Sanchez, Patricia Ortiz-Tello, Bernardo A. Pons-Estel, Eduardo Acevedo-Vasquez, Pedro Miranda, Carl D. Langefeld, Simon Gravel, Marta E. Alarcón-Riquelme, Carlos D. Bustamante
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10.1371/journal.pgen.1005545

PLOS Genetics The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization
October 13, 2015 Yannick R. Brunet, Abdelrahim Zoued, Frédéric Boyer, Badreddine Douzi, Eric Cascales
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10.1371/journal.pgen.1005641

PLOS Genetics Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape
November 4, 2015 Scarlet S. Shell, Jing Wang, Pascal Lapierre, Mushtaq Mir, Michael R. Chase, Margaret M. Pyle, Richa Gawande, Rushdy Ahmad, David A. Sarracino, Thomas R. Ioerger, Sarah M. Fortune, Keith M. Derbyshire, Joseph T. Wade, Todd A. Gray
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10.1371/journal.pgen.1004920

PLOS Genetics Century-scale Methylome Stability in a Recently Diverged Arabidopsis thaliana Lineage
January 8, 2015 Jörg Hagmann, Claude Becker, Jonas Müller, Oliver Stegle, Rhonda C. Meyer, George Wang, Korbinian Schneeberger, Joffrey Fitz, Thomas Altmann, Joy Bergelson, Karsten Borgwardt, Detlef Weigel
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10.1371/journal.pgen.1004966

PLOS Genetics Genomics of Divergence along a Continuum of Parapatric Population Differentiation
February 13, 2015 Philine G. D. Feulner, Frédéric J. J. Chain, Mahesh Panchal, Yun Huang, Christophe Eizaguirre, Martin Kalbe, Tobias L. Lenz, Irene E. Samonte, Monika Stoll, Erich Bornberg-Bauer, Thorsten B. H. Reusch, Manfred Milinski
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10.1371/journal.pgen.1005421

PLOS Genetics New Routes to Phylogeography: A Bayesian Structured Coalescent Approximation
August 12, 2015 Nicola De Maio, Chieh-Hsi Wu, Kathleen M O’Reilly, Daniel Wilson
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10.1371/journal.pgen.1005120

PLOS Genetics Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis
March 27, 2015 Nieves Ayllón, Margarita Villar, Ruth C. Galindo, Katherine M. Kocan, Radek Šíma, Juan A. López, Jesús Vázquez, Pilar Alberdi, Alejandro Cabezas-Cruz, Petr Kopáček, José de la Fuente
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10.1371/journal.pgen.1004994

PLOS Genetics Discovery of Transcription Factors and Regulatory Regions Driving In Vivo Tumor Development by ATAC-seq and FAIRE-seq Open Chromatin Profiling
February 13, 2015 Kristofer Davie, Jelle Jacobs, Mardelle Atkins, Delphine Potier, Valerie Christiaens, Georg Halder, Stein Aerts
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10.1371/journal.pgen.1005068

PLOS Genetics The Genetic Legacy of the Expansion of Turkic-Speaking Nomads across Eurasia
April 21, 2015 Bayazit Yunusbayev, Mait Metspalu, Ene Metspalu, Albert Valeev, Sergei Litvinov, Ruslan Valiev, Vita Akhmetova, Elena Balanovska, Oleg Balanovsky, Shahlo Turdikulova, Dilbar Dalimova, Pagbajabyn Nymadawa, Ardeshir Bahmanimehr, Hovhannes Sahakyan, Kristiina Tambets, Sardana Fedorova, Nikolay Barashkov, Irina Khidiyatova, Evelin Mihailov, Rita Khusainova, Larisa Damba, Miroslava Derenko, Boris Malyarchuk, Ludmila Osipova, Mikhail Voevoda, Levon Yepiskoposyan, Toomas Kivisild, Elza Khusnutdinova, Richard Villems
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10.1371/journal.pgen.1004916

PLOS Genetics PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination
January 8, 2015 Christopher L. Baker, Shimpei Kajita, Michael Walker, Ruth L. Saxl, Narayanan Raghupathy, Kwangbom Choi, Petko M. Petkov, Kenneth Paigen
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10.1371/journal.pgen.1005628

PLOS Genetics The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males
November 9, 2015 Fernando Ayllon, Erik Kjærner-Semb, Tomasz Furmanek, Vidar Wennevik, Monica F. Solberg, Geir Dahle, Geir Lasse Taranger, Kevin A. Glover, Markus Sällman Almén, Carl J Rubin, Rolf B. Edvardsen, Anna Wargelius
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10.1371/journal.pgen.1005262

PLOS Genetics Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia
June 23, 2015 Sabine Topka, Joseph Vijai, Michael F. Walsh, Lauren Jacobs, Ann Maria, Danylo Villano, Pragna Gaddam, Gang Wu, Rose B. McGee, Emily Quinn, Hiroto Inaba, Christine Hartford, Ching-hon Pui, Alberto Pappo, Michael Edmonson, Michael Y. Zhang, Polina Stepensky, Peter Steinherz, Kasmintan Schrader, Anne Lincoln, James Bussel, Steve M. Lipkin, Yehuda Goldgur, Mira Harit, Zsofia K. Stadler, Charles Mullighan, Michael Weintraub, Akiko Shimamura, Jinghui Zhang, James R. Downing, Kim E. Nichols, Kenneth Offit
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10.1371/journal.pgen.1004996

PLOS Genetics An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging
February 18, 2015 Tian Yuan, Yinming Jiao, Simone de Jong, Roel A. Ophoff, Stephan Beck, Andrew E. Teschendorff
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10.1371/journal.pgen.1004943

PLOS Genetics DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining
January 28, 2015 Sean M. Howard, Diana A. Yanez, Jeremy M. Stark
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10.1371/journal.pgen.1005165

PLOS Genetics The Power of Gene-Based Rare Variant Methods to Detect Disease-Associated Variation and Test Hypotheses About Complex Disease
April 23, 2015 Loukas Moutsianas, Vineeta Agarwala, Christian Fuchsberger, Jason Flannick, Manuel A. Rivas, Kyle J. Gaulton, Patrick K. Albers, GoT2D Consortium , Gil McVean, Michael Boehnke, David Altshuler, Mark I. McCarthy
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10.1371/journal.pgen.1004901

PLOS Genetics Inflammation-Induced Cell Proliferation Potentiates DNA Damage-Induced Mutations In Vivo
February 3, 2015 Orsolya Kiraly, Guanyu Gong, Werner Olipitz, Sureshkumar Muthupalani, Bevin P. Engelward
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10.1371/journal.pgen.1005121

PLOS Genetics The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition
May 7, 2015 John B. Moldovan, John V. Moran
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10.1371/journal.pgen.1005128

PLOS Genetics A Multi-layered Protein Network Stabilizes the Escherichia coli FtsZ-ring and Modulates Constriction Dynamics
April 7, 2015 Jackson Buss, Carla Coltharp, Gleb Shtengel, Xinxing Yang, Harald Hess, Jie Xiao
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10.1371/journal.pgen.1005726

PLOS Genetics fMiRNA-192 and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma
December 28, 2015 Yunxia Ge, Xiaodan Yan, Yiguang Jin, Xinyu Yang, Xiang Yu, Liqing Zhou, Sichong Han, Qipeng Yuan, Ming Yang
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10.1371/journal.pgen.1005635

PLOS Genetics Adaptation to High Ethanol Reveals Complex Evolutionary Pathways
November 6, 2015 Karin Voordeckers, Jacek Kominek, Anupam Das, Adriana Espinosa-Cantú, Dries De Maeyer, Ahmed Arslan, Michiel Van Pee, Elisa van der Zande, Wim Meert, Yudi Yang, Bo Zhu, Kathleen Marchal, Alexander DeLuna, Vera Van Noort, Rob Jelier, Kevin J. Verstrepen
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10.1371/journal.pgen.1004970

PLOS Genetics Naturally Occurring Differences in CENH3 Affect Chromosome Segregation in Zygotic Mitosis of Hybrids
January 26, 2015 Shamoni Maheshwari, Ek Han Tan, Allan West, F. Chris H. Franklin, Simon W. L. Chan, Luca Comai
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10.1371/journal.pgen.1005509

PLOS Genetics Synergistic and Dose-Controlled Regulation of Cellulase Gene Expression in Penicillium oxalicum
September 11, 2015 Zhonghai Li, Guangshan Yao, Ruimei Wu, Liwei Gao, Qinbiao Kan, Meng Liu, Piao Yang, Guodong Liu, Yuqi Qin, Xin Song, Yaohua Zhong, Xu Fang, Yinbo Qu
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10.1371/journal.pgen.1005209

PLOS Genetics The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster
May 28, 2015 Hiroko Sano, Akira Nakamura, Michael J. Texada, James W. Truman, Hiroshi Ishimoto, Azusa Kamikouchi, Yutaka Nibu, Kazuhiko Kume, Takanori Ida, Masayasu Kojima
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10.1371/journal.pgen.1005207

PLOS Genetics A Simple Auxin Transcriptional Response System Regulates Multiple Morphogenetic Processes in the Liverwort Marchantia polymorpha
May 28, 2015 Eduardo Flores-Sandoval, D. Magnus Eklund, John L. Bowman
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10.1371/journal.pgen.1005199

PLOS Genetics Beyond Glycolysis: GAPDHs Are Multi-functional Enzymes Involved in Regulation of ROS, Autophagy, and Plant Immune Responses
April 28, 2015 Elizabeth Henry, Nicholas Fung, Jun Liu, Georgia Drakakaki, Gitta Coaker
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10.1371/journal.pgen.1005035

PLOS Genetics A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension
March 18, 2015 Tianxiao Huan, Tõnu Esko, Marjolein J. Peters, Luke C. Pilling, Katharina Schramm, Claudia Schurmann, Brian H. Chen, Chunyu Liu, Roby Joehanes, Andrew D. Johnson, Chen Yao, Sai-xia Ying, Paul Courchesne, Lili Milani, Nalini Raghavachari, Richard Wang, Poching Liu, Eva Reinmaa, Abbas Dehghan, Albert Hofman, André G. Uitterlinden, Dena G. Hernandez, Stefania Bandinelli, Andrew Singleton, David Melzer, Andres Metspalu, Maren Carstensen, Harald Grallert, Christian Herder, Thomas Meitinger, Annette Peters, Michael Roden, Melanie Waldenberger, Marcus Dörr, Stephan B. Felix, Tanja Zeller, International Consortium for Blood Pressure GWAS (ICBP) , Ramachandran Vasan, Christopher J. O'Donnell, Peter J. Munson, Xia Yang, Holger Prokisch, Uwe Völker, Joyce B. J. van Meurs, Luigi Ferrucci, Daniel Levy
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10.1371/journal.pgen.1005668

PLOS Genetics Probing Xist RNA Structure in Cells Using Targeted Structure-Seq
December 8, 2015 Rui Fang, Walter N. Moss, Michael Rutenberg-Schoenberg, Matthew D. Simon
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10.1371/journal.pgen.1005298

PLOS Genetics Replication and Active Partition of Integrative and Conjugative Elements (ICEs) of the SXT/R391 Family: The Line between ICEs and Conjugative Plasmids Is Getting Thinner
June 10, 2015 Nicolas Carraro, Dominique Poulin, Vincent Burrus
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10.1371/journal.pgen.1005190

PLOS Genetics Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria
May 4, 2015 Louis S. Ates, Roy Ummels, Susanna Commandeur, Robert van der Weerd, Marion Sparrius, Eveline Weerdenburg, Marina Alber, Rainer Kalscheuer, Sander R. Piersma, Abdallah M. Abdallah, Moataz Abd El Ghany, Alyaa M. Abdel-Haleem, Arnab Pain, Connie R. Jiménez, Wilbert Bitter, Edith N.G. Houben
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10.1371/journal.pgen.1004945

PLOS Genetics A Truncated NLR Protein, TIR-NBS2, Is Required for Activated Defense Responses in the exo70B1 Mutant
January 24, 2015 Ting Zhao, Lu Rui, Juan Li, Marc T. Nishimura, John P. Vogel, Na Liu, Simu Liu, Yaofei Zhao, Jeffery L. Dangl, Dingzhong Tang
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10.1371/journal.pgen.1005084

PLOS Genetics Auxin-Mediated Transcriptional System with a Minimal Set of Components Is Critical for Morphogenesis through the Life Cycle in Marchantia polymorpha
May 28, 2015 Hirotaka Kato, Kimitsune Ishizaki, Masaru Kouno, Makoto Shirakawa, John L. Bowman, Ryuichi Nishihama, Takayuki Kohchi
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10.1371/journal.pgen.1004876

PLOS Genetics Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
January 27, 2015 Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A. Rivas, Heather M. Highland, Adam E. Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J. Gaulton, Tanya M. Teslovich, N. William Rayner, Neil R. Robertson, Nicola L. Beer, Jana K. Rundle, Jette Bork-Jensen, Claes Ladenvall, Christine Blancher, David Buck, Gemma Buck, Noël P. Burtt, Stacey Gabriel, Anette P. Gjesing, Christopher J. Groves, Mette Hollensted, Jeroen R. Huyghe, Anne U. Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S. Small, Heather M. Stringham, Ann-Christine Syvänen, Joseph Trakalo, Goncalo Abecasis, Graeme I. Bell, John Blangero, Nancy J. Cox, Ravindranath Duggirala, Craig L. Hanis, Mark Seielstad, James G. Wilson, Cramer Christensen, Ivan Brandslund, Rainer Rauramaa, Gabriela L. Surdulescu, Alex S. F. Doney, Lars Lannfelt, Allan Linneberg, Bo Isomaa, Tiinamaija Tuomi, Marit E. Jørgensen, Torben Jørgensen, Johanna Kuusisto, Matti Uusitupa, Veikko Salomaa, Timothy D. Spector, Andrew D. Morris, Colin N. A. Palmer, Francis S. Collins, Karen L. Mohlke, Richard N. Bergman, Erik Ingelsson, Lars Lind, Jaakko Tuomilehto, Torben Hansen, Richard M. Watanabe, Inga Prokopenko, Josee Dupuis, Fredrik Karpe, Leif Groop, Markku Laakso, Oluf Pedersen, Jose C. Florez, Andrew P. Morris, David Altshuler, James B. Meigs, Michael Boehnke, Mark I. McCarthy, Cecilia M. Lindgren, Anna L. Gloyn, On Behalf of the T2D-GENES consortium and GoT2D consortium
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10.1371/journal.pgen.1005498

PLOS Genetics A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism
September 25, 2015 Anu Loukola, Jadwiga Buchwald, Richa Gupta, Teemu Palviainen, Jenni Hällfors, Emmi Tikkanen, Tellervo Korhonen, Miina Ollikainen, Antti-Pekka Sarin, Samuli Ripatti, Terho Lehtimäki, Olli Raitakari, Veikko Salomaa, Richard J. Rose, Rachel F. Tyndale, Jaakko Kaprio
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10.1371/journal.pgen.1005634

PLOS Genetics EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes
December 18, 2015 Yinhua Jin, Nati Ha, Marta Forés, Jinyi Xiang, Christine Gläßer, Julieta Maldera, Gerardo Jiménez, Bruce A. Edgar
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10.1371/journal.pgen.1005467

PLOS Genetics Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer
August 21, 2015 Jun Ho Ji, Young Lyun Oh, Mineui Hong, Jae Won Yun, Hyun-Woo Lee, DeokGeun Kim, Yongick Ji, Duk-Hwan Kim, Woong-Yang Park, Hyun-Tae Shin, Kyoung-Mee Kim, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun
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10.1371/journal.pgen.1005142

PLOS Genetics Methylation-Sensitive Expression of a DNA Demethylase Gene Serves As an Epigenetic Rheostat
March 31, 2015 Ben P. Williams, Daniela Pignatta, Steven Henikoff, Mary Gehring
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10.1371/journal.pgen.1004928

PLOS Genetics Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break
January 8, 2015 Matteo Ferrari, Diego Dibitetto, Giuseppe De Gregorio, Vinay V. Eapen, Chetan C. Rawal, Federico Lazzaro, Michael Tsabar, Federica Marini, James E. Haber, Achille Pellicioli
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10.1371/journal.pgen.1005373

PLOS Genetics Large-Scale Phenomics Identifies Primary and Fine-Tuning Roles for CRKs in Responses Related to Oxidative Stress
July 21, 2015 Gildas Bourdais, Paweł Burdiak, Adrien Gauthier, Lisette Nitsch, Jarkko Salojärvi, Channabasavangowda Rayapuram, Niina Idänheimo, Kerri Hunter, Sachie Kimura, Ebe Merilo, Aleksia Vaattovaara, Krystyna Oracz, David Kaufholdt, Andres Pallon, Damar Tri Anggoro, Dawid Glów, Jennifer Lowe, Ji Zhou, Omid Mohammadi, Tuomas Puukko, Andreas Albert, Hans Lang, Dieter Ernst, Hannes Kollist, Mikael Brosché, Jörg Durner, Jan Willem Borst, David B. Collinge, Stanisław Karpiński, Michael F. Lyngkjær, Silke Robatzek, Jaakko Kangasjärvi, on behalf of the CRK Consortium , Michael Wrzaczek
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10.1371/journal.pgen.1005367

PLOS Genetics SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation
July 2, 2015 Siqi Hu, Jian Li, Fengwen Xu, Shan Mei, Yann Le Duff, Lijuan Yin, Xiaojing Pang, Shan Cen, Qi Jin, Chen Liang, Fei Guo
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10.1371/journal.pgen.1005352

PLOS Genetics Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND)
August 25, 2015 Sudha K. Iyengar, John R. Sedor, Barry I. Freedman, W. H. Linda Kao, Matthias Kretzler, Benjamin J. Keller, Hanna E. Abboud, Sharon G. Adler, Lyle G. Best, Donald W. Bowden, Allison Burlock, Yii-Der Ida Chen, Shelley A. Cole, Mary E. Comeau, Jeffrey M. Curtis, Jasmin Divers, Christiane Drechsler, Ravi Duggirala, Robert C. Elston, Xiuqing Guo, Huateng Huang, Michael Marcus Hoffmann, Barbara V. Howard, Eli Ipp, Paul L. Kimmel, Michael J. Klag, William C. Knowler, Orly F. Kohn, Tennille S. Leak, David J. Leehey, Man Li, Alka Malhotra, Winfried März, Viji Nair, Robert G. Nelson, Susanne B. Nicholas, Stephen J. O’Brien, Madeleine V. Pahl, Rulan S. Parekh, Marcus G. Pezzolesi, Rebekah S. Rasooly, Charles N. Rotimi, Jerome I. Rotter, Jeffrey R. Schelling, Michael F. Seldin, Vallabh O. Shah, Adam M. Smiles, Michael W. Smith, Kent D. Taylor, Farook Thameem, Denyse P. Thornley-Brown, Barbara J. Truitt, Christoph Wanner, E. Jennifer Weil, Cheryl A. Winkler, Philip G. Zager, Robert P. Igo Jr, Robert L. Hanson, Carl D. Langefeld, Family Investigation of Nephropathy and Diabetes (FIND)
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10.1371/journal.pgen.1005252

PLOS Genetics The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition
May 22, 2015 John L. Goodier, Gavin C. Pereira, Ling E. Cheung, Rebecca J. Rose, Haig H. Kazazian Jr.
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10.1371/journal.pgen.1005596

PLOS Genetics The Rise and Fall of an Evolutionary Innovation: Contrasting Strategies of Venom Evolution in Ancient and Young Animals
October 22, 2015 Kartik Sunagar, Yehu Moran
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10.1371/journal.pgen.1005397

PLOS Genetics Evidence for a Common Origin of Blacksmiths and Cultivators in the Ethiopian Ari within the Last 4500 Years: Lessons for Clustering-Based Inference
August 20, 2015 Lucy van Dorp, David Balding, Simon Myers, Luca Pagani, Chris Tyler-Smith, Endashaw Bekele, Ayele Tarekegn, Mark G. Thomas, Neil Bradman, Garrett Hellenthal

2014

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10.1371/journal.pgen.1004383

PLOS Genetics Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
May 15, 2014 Claudia Giambartolomei, Damjan Vukcevic, Eric E. Schadt, Lude Franke, Aroon D. Hingorani, Chris Wallace, Vincent Plagnol
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10.1371/journal.pgen.1004016

PLOS Genetics Genome Sequencing Highlights the Dynamic Early History of Dogs
January 16, 2014 Adam H. Freedman, Ilan Gronau, Rena M. Schweizer, Diego Ortega-Del Vecchyo, Eunjung Han, Pedro M. Silva, Marco Galaverni, Zhenxin Fan, Peter Marx, Belen Lorente-Galdos, Holly Beale, Oscar Ramirez, Farhad Hormozdiari, Can Alkan, Carles Vilà, Kevin Squire, Eli Geffen, Josip Kusak, Adam R. Boyko, Heidi G. Parker, Clarence Lee, Vasisht Tadigotla, Adam Siepel, Carlos D. Bustamante, Timothy T. Harkins, Stanley F. Nelson, Elaine A. Ostrander, Tomas Marques-Bonet, Robert K. Wayne, John Novembre
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10.1371/journal.pgen.1004234

PLOS Genetics A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness
April 17, 2014 Jared O'Connell, Deepti Gurdasani, Olivier Delaneau, Nicola Pirastu, Sheila Ulivi, Massimiliano Cocca, Michela Traglia, Jie Huang, Jennifer E. Huffman, Igor Rudan, Ruth McQuillan, Ross M. Fraser, Harry Campbell, Ozren Polasek, Gershim Asiki, Kenneth Ekoru, Caroline Hayward, Alan F. Wright, Veronique Vitart, Pau Navarro, Jean-Francois Zagury, James F. Wilson, Daniela Toniolo, Paolo Gasparini, Nicole Soranzo, Manjinder S. Sandhu, Jonathan Marchini
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10.1371/journal.pgen.1004160

PLOS Genetics Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion
March 6, 2014 Tasnim Dayeh, Petr Volkov, Sofia Salö, Elin Hall, Emma Nilsson, Anders H. Olsson, Clare L. Kirkpatrick, Claes B. Wollheim, Lena Eliasson, Tina Rönn, Karl Bacos, Charlotte Ling
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10.1371/journal.pgen.1004580

PLOS Genetics Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments
September 4, 2014 Claire S. Leblond, Caroline Nava, Anne Polge, Julie Gauthier, Guillaume Huguet, Serge Lumbroso, Fabienne Giuliano, Coline Stordeur, Christel Depienne, Kevin Mouzat, Dalila Pinto, Jennifer Howe, Nathalie Lemière, Christelle M. Durand, Jessica Guibert, Elodie Ey, Roberto Toro, Hugo Peyre, Alexandre Mathieu, Frédérique Amsellem, Maria Rastam, I. Carina Gillberg, Gudrun A. Rappold, Richard Holt, Anthony P. Monaco, Elena Maestrini, Pilar Galan, Delphine Heron, Aurélia Jacquette, Alexandra Afenjar, Agnès Rastetter, Alexis Brice, Françoise Devillard, Brigitte Assouline, Fanny Laffargue, James Lespinasse, Jean Chiesa, François Rivier, Dominique Bonneau, Beatrice Regnault, Diana Zelenika, Marc Delepine, Mark Lathrop, Damien Sanlaville, Caroline Schluth-Bolard, Patrick Edery, Laurence Perrin, Anne Claude Tabet, Michael J. Schmeisser, Tobias M. Boeckers, Mary Coleman, Daisuke Sato, Peter Szatmari, Stephen W. Scherer, Guy A. Rouleau, Catalina Betancur, Marion Leboyer, Christopher Gillberg, Richard Delorme, Thomas Bourgeron
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10.1371/journal.pgen.1004412

PLOS Genetics A Population Genetic Signal of Polygenic Adaptation
August 7, 2014 Jeremy J. Berg, Graham Coop
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10.1371/journal.pgen.1004775

PLOS Genetics Genomic Evidence of Rapid and Stable Adaptive Oscillations over Seasonal Time Scales in Drosophila
November 6, 2014 Alan O. Bergland, Emily L. Behrman, Katherine R. O'Brien, Paul S. Schmidt, Dmitri A. Petrov
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10.1371/journal.pgen.1004820

PLOS Genetics Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice
December 4, 2014 Xin Zhou, Klaus von der Mark, Stephen Henry, William Norton, Henry Adams, Benoit de Crombrugghe
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10.1371/journal.pgen.1004772

PLOS Genetics De Novo Mutations in Moderate or Severe Intellectual Disability
October 30, 2014 Fadi F. Hamdan, Myriam Srour, Jose-Mario Capo-Chichi, Hussein Daoud, Christina Nassif, Lysanne Patry, Christine Massicotte, Amirthagowri Ambalavanan, Dan Spiegelman, Ousmane Diallo, Edouard Henrion, Alexandre Dionne-Laporte, Anne Fougerat, Alexey V. Pshezhetsky, Sunita Venkateswaran, Guy A. Rouleau, Jacques L. Michaud
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10.1371/journal.pgen.1004047

PLOS Genetics In-Vivo Quantitative Proteomics Reveals a Key Contribution of Post-Transcriptional Mechanisms to the Circadian Regulation of Liver Metabolism
January 2, 2014 Maria S. Robles, Jürgen Cox, Matthias Mann
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10.1371/journal.pgen.1004494

PLOS Genetics Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population
July 31, 2014 Elaine T. Lim, Peter Würtz, Aki S. Havulinna, Priit Palta, Taru Tukiainen, Karola Rehnström, Tõnu Esko, Reedik Mägi, Michael Inouye, Tuuli Lappalainen, Yingleong Chan, Rany M. Salem, Monkol Lek, Jason Flannick, Xueling Sim, Alisa Manning, Claes Ladenvall, Suzannah Bumpstead, Eija Hämäläinen, Kristiina Aalto, Mikael Maksimow, Marko Salmi, Stefan Blankenberg, Diego Ardissino, Svati Shah, Benjamin Horne, Ruth McPherson, Gerald K. Hovingh, Muredach P. Reilly, Hugh Watkins, Anuj Goel, Martin Farrall, Domenico Girelli, Alex P. Reiner, Nathan O. Stitziel, Sekar Kathiresan, Stacey Gabriel, Jeffrey C. Barrett, Terho Lehtimäki, Markku Laakso, Leif Groop, Jaakko Kaprio, Markus Perola, Mark I. McCarthy, Michael Boehnke, David M. Altshuler, Cecilia M. Lindgren, Joel N. Hirschhorn, Andres Metspalu, Nelson B. Freimer, Tanja Zeller, Sirpa Jalkanen, Seppo Koskinen, Olli Raitakari, Richard Durbin, Daniel G. MacArthur, Veikko Salomaa, Samuli Ripatti, Mark J. Daly, Aarno Palotie, for the Sequencing Initiative Suomi (SISu) Project
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10.1371/journal.pgen.1004722

PLOS Genetics Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies
October 30, 2014 Gleb Kichaev, Wen-Yun Yang, Sara Lindstrom, Farhad Hormozdiari, Eleazar Eskin, Alkes L. Price, Peter Kraft, Bogdan Pasaniuc
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10.1371/journal.pgen.1004254

PLOS Genetics Worldwide Patterns of Ancestry, Divergence, and Admixture in Domesticated Cattle
March 27, 2014 Jared E. Decker, Stephanie D. McKay, Megan M. Rolf, JaeWoo Kim, Antonio Molina Alcalá, Tad S. Sonstegard, Olivier Hanotte, Anders Götherström, Christopher M. Seabury, Lisa Praharani, Masroor Ellahi Babar, Luciana Correia de Almeida Regitano, Mehmet Ali Yildiz, Michael P. Heaton, Wan-Sheng Liu, Chu-Zhao Lei, James M. Reecy, Muhammad Saif-Ur-Rehman, Robert D. Schnabel, Jeremy F. Taylor
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10.1371/journal.pgen.1004261

PLOS Genetics Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation
April 17, 2014 Guilhem Janbon, Kate L. Ormerod, Damien Paulet, Edmond J. Byrnes III, Vikas Yadav, Gautam Chatterjee, Nandita Mullapudi, Chung-Chau Hon, R. Blake Billmyre, François Brunel, Yong-Sun Bahn, Weidong Chen, Yuan Chen, Eve W. L. Chow, Jean-Yves Coppée, Anna Floyd-Averette, Claude Gaillardin, Kimberly J. Gerik, Jonathan Goldberg, Sara Gonzalez-Hilarion, Sharvari Gujja, Joyce L. Hamlin, Yen-Ping Hsueh, Giuseppe Ianiri, Steven Jones, Chinnappa D. Kodira, Lukasz Kozubowski, Woei Lam, Marco Marra, Larry D. Mesner, Piotr A. Mieczkowski, Frédérique Moyrand, Kirsten Nielsen, Caroline Proux, Tristan Rossignol, Jacqueline E. Schein, Sheng Sun, Carolin Wollschlaeger, Ian A. Wood, Qiandong Zeng, Cécile Neuvéglise, Carol S. Newlon, John R. Perfect, Jennifer K. Lodge, Alexander Idnurm, Jason E. Stajich, James W. Kronstad, Kaustuv Sanyal, Joseph Heitman, James A. Fraser, Christina A. Cuomo, Fred S. Dietrich
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10.1371/journal.pgen.1004572

PLOS Genetics Admixture in Latin America: Geographic Structure, Phenotypic Diversity and Self-Perception of Ancestry Based on 7,342 Individuals
September 25, 2014 Andrés Ruiz-Linares, Kaustubh Adhikari, Victor Acuña-Alonzo, Mirsha Quinto-Sanchez, Claudia Jaramillo, William Arias, Macarena Fuentes, María Pizarro, Paola Everardo, Francisco de Avila, Jorge Gómez-Valdés, Paola León-Mimila, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Mari-Wyn Burley, Esra Konca, Marcelo Zagonel de Oliveira, Mauricio Roberto Veronez, Marta Rubio-Codina, Orazio Attanasio, Sahra Gibbon, Nicolas Ray, Carla Gallo, Giovanni Poletti, Javier Rosique, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, David Balding, Rolando Gonzalez-José
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10.1371/journal.pgen.1004318

PLOS Genetics R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome
May 1, 2014 Matthias Groh, Michele M. P. Lufino, Richard Wade-Martins, Natalia Gromak
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10.1371/journal.pgen.1004269

PLOS Genetics Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples
April 10, 2014 Peter M. Visscher, Gibran Hemani, Anna A. E. Vinkhuyzen, Guo-Bo Chen, Sang Hong Lee, Naomi R. Wray, Michael E. Goddard, Jian Yang
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10.1371/journal.pgen.1004776

PLOS Genetics Dissemination of Cephalosporin Resistance Genes between Escherichia coli Strains from Farm Animals and Humans by Specific Plasmid Lineages
December 18, 2014 Mark de Been, Val F. Lanza, María de Toro, Jelle Scharringa, Wietske Dohmen, Yu Du, Juan Hu, Ying Lei, Ning Li, Ave Tooming-Klunderud, Dick J. J. Heederik, Ad C. Fluit, Marc J. M. Bonten, Rob J. L. Willems, Fernando de la Cruz, Willem van Schaik
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10.1371/journal.pgen.1004432

PLOS Genetics Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells
June 5, 2014 Foad Rouhani, Natsuhiko Kumasaka, Miguel Cardoso de Brito, Allan Bradley, Ludovic Vallier, Daniel Gaffney
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10.1371/journal.pgen.1004518

PLOS Genetics Requirements for Pseudomonas aeruginosa Acute Burn and Chronic Surgical Wound Infection
July 24, 2014 Keith H. Turner, Jake Everett, Urvish Trivedi, Kendra P. Rumbaugh, Marvin Whiteley
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10.1371/journal.pgen.1004078

PLOS Genetics Single Nucleus Genome Sequencing Reveals High Similarity among Nuclei of an Endomycorrhizal Fungus
January 9, 2014 Kui Lin, Erik Limpens, Zhonghua Zhang, Sergey Ivanov, Diane G. O. Saunders, Desheng Mu, Erli Pang, Huifen Cao, Hwangho Cha, Tao Lin, Qian Zhou, Yi Shang, Ying Li, Trupti Sharma, Robin van Velzen, Norbert de Ruijter, Duur K. Aanen, Joe Win, Sophien Kamoun, Ton Bisseling, René Geurts, Sanwen Huang
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10.1371/journal.pgen.1004606

PLOS Genetics Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer’s Disease and Related Dementias
September 4, 2014 Gary W. Beecham, Kara Hamilton, Adam C. Naj, Eden R. Martin, Matt Huentelman, Amanda J. Myers, Jason J. Corneveaux, John Hardy, Jean-Paul Vonsattel, Steven G. Younkin, David A. Bennett, Philip L. De Jager, Eric B. Larson, Paul K. Crane, M. Ilyas Kamboh, Julia K. Kofler, Deborah C. Mash, Linda Duque, John R. Gilbert, Harry Gwirtsman, Joseph D. Buxbaum, Patricia Kramer, Dennis W. Dickson, Lindsay A. Farrer, Matthew P. Frosch, Bernardino Ghetti, Jonathan L. Haines, Bradley T. Hyman, Walter A. Kukull, Richard P. Mayeux, Margaret A. Pericak-Vance, Julie A. Schneider, John Q. Trojanowski, Eric M. Reiman, the Alzheimer's Disease Genetics Consortium (ADGC) , Gerard D. Schellenberg, Thomas J. Montine
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10.1371/journal.pgen.1004475

PLOS Genetics The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation
July 10, 2014 Andrew S. Brohl, David A. Solomon, Wendy Chang, Jianjun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hongling Liao, Xinyu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy Triche, Andrew E. Horvai, Markku Miettinen, Jun S. Wei, Daniel Catchpool, Antonio Llombart-Bosch, Todd Waldman, Javed Khan
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10.1371/journal.pgen.1004135

PLOS Genetics Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma
February 13, 2014 Mitesh J. Borad, Mia D. Champion, Jan B. Egan, Winnie S. Liang, Rafael Fonseca, Alan H. Bryce, Ann E. McCullough, Michael T. Barrett, Katherine Hunt, Maitray D. Patel, Scott W. Young, Joseph M. Collins, Alvin C. Silva, Rachel M. Condjella, Matthew Block, Robert R. McWilliams, Konstantinos N. Lazaridis, Eric W. Klee, Keith C. Bible, Pamela Harris, Gavin R. Oliver, Jaysheel D. Bhavsar, Asha A. Nair, Sumit Middha, Yan Asmann, Jean-Pierre Kocher, Kimberly Schahl, Benjamin R. Kipp, Emily G. Barr Fritcher, Angela Baker, Jessica Aldrich, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Irene Cherni, Sara Nasser, Rebecca Reiman, Lori Phillips, Jackie McDonald, Jonathan Adkins, Stephen D. Mastrian, Pamela Placek, Aprill T. Watanabe, Janine LoBello, Haiyong Han, Daniel Von Hoff, David W. Craig, A. Keith Stewart, John D. Carpten
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10.1371/journal.pgen.1004283

PLOS Genetics A Synthetic Community Approach Reveals Plant Genotypes Affecting the Phyllosphere Microbiota
April 17, 2014 Natacha Bodenhausen, Miriam Bortfeld-Miller, Martin Ackermann, Julia A. Vorholt
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10.1371/journal.pgen.1004573

PLOS Genetics Genome Wide Association Studies Using a New Nonparametric Model Reveal the Genetic Architecture of 17 Agronomic Traits in an Enlarged Maize Association Panel
September 11, 2014 Ning Yang, Yanli Lu, Xiaohong Yang, Juan Huang, Yang Zhou, Farhan Ali, Weiwei Wen, Jie Liu, Jiansheng Li, Jianbing Yan
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10.1371/journal.pgen.1004663

PLOS Genetics Methylation QTLs Are Associated with Coordinated Changes in Transcription Factor Binding, Histone Modifications, and Gene Expression Levels
September 18, 2014 Nicholas E. Banovich, Xun Lan, Graham McVicker, Bryce van de Geijn, Jacob F. Degner, John D. Blischak, Julien Roux, Jonathan K. Pritchard, Yoav Gilad
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10.1371/journal.pgen.1004868

PLOS Genetics Genome-Wide Analysis of DNA Methylation Dynamics during Early Human Development
December 11, 2014 Hiroaki Okae, Hatsune Chiba, Hitoshi Hiura, Hirotaka Hamada, Akiko Sato, Takafumi Utsunomiya, Hiroyuki Kikuchi, Hiroaki Yoshida, Atsushi Tanaka, Mikita Suyama, Takahiro Arima
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10.1371/journal.pgen.1004801

PLOS Genetics Large-scale Metabolomic Profiling Identifies Novel Biomarkers for Incident Coronary Heart Disease
December 11, 2014 Andrea Ganna, Samira Salihovic, Johan Sundström, Corey D. Broeckling, Åsa K. Hedman, Patrik K. E. Magnusson, Nancy L. Pedersen, Anders Larsson, Agneta Siegbahn, Mihkel Zilmer, Jessica Prenni, Johan Ärnlöv, Lars Lind, Tove Fall, Erik Ingelsson
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10.1371/journal.pgen.1004094

PLOS Genetics Nannochloropsis Genomes Reveal Evolution of Microalgal Oleaginous Traits
January 9, 2014 Dongmei Wang, Kang Ning, Jing Li, Jianqiang Hu, Danxiang Han, Hui Wang, Xiaowei Zeng, Xiaoyan Jing, Qian Zhou, Xiaoquan Su, Xingzhi Chang, Anhui Wang, Wei Wang, Jing Jia, Li Wei, Yi Xin, Yinghe Qiao, Ranran Huang, Jie Chen, Bo Han, Kangsup Yoon, Russell T. Hill, Yonathan Zohar, Feng Chen, Qiang Hu, Jian Xu
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10.1371/journal.pgen.1004236

PLOS Genetics CYP6 P450 Enzymes and ACE-1 Duplication Produce Extreme and Multiple Insecticide Resistance in the Malaria Mosquito Anopheles gambiae
March 20, 2014 Constant Edi, Luc Djogbenou, Adam Jenkins, Kimberly Regna, Marc Muskavitch, Rodolphe Poupardin, Christopher Jones, John Essandoh, Guillaume Kétoh, Mark Paine, Benjamin Koudou, Martin Donnelly, Hilary Ranson, David Weetman
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10.1371/journal.pgen.1004487

PLOS Genetics Comparative Phylogenomics Uncovers the Impact of Symbiotic Associations on Host Genome Evolution
July 17, 2014 Pierre-Marc Delaux, Kranthi Varala, Patrick P. Edger, Gloria M. Coruzzi, J. Chris Pires, Jean-Michel Ané
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10.1371/journal.pgen.1004148

PLOS Genetics Classic Selective Sweeps Revealed by Massive Sequencing in Cattle
February 27, 2014 Saber Qanbari, Hubert Pausch, Sandra Jansen, Mehmet Somel, Tim M. Strom, Ruedi Fries, Rasmus Nielsen, Henner Simianer
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10.1371/journal.pgen.1004458

PLOS Genetics Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility
July 10, 2014 Timothy G. Jenkins, Kenneth I. Aston, Christian Pflueger, Bradley R. Cairns, Douglas T. Carrell
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10.1371/journal.pgen.1004416

PLOS Genetics The HY5-PIF Regulatory Module Coordinates Light and Temperature Control of Photosynthetic Gene Transcription
June 12, 2014 Gabriela Toledo-Ortiz, Henrik Johansson, Keun Pyo Lee, Jordi Bou-Torrent, Kelly Stewart, Gavin Steel, Manuel Rodríguez-Concepción, Karen J. Halliday
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10.1371/journal.pgen.1004115

PLOS Genetics How a Retrotransposon Exploits the Plant’s Heat Stress Response for Its Activation
January 30, 2014 Vladimir V. Cavrak, Nicole Lettner, Suraj Jamge, Agata Kosarewicz, Laura Maria Bayer, Ortrun Mittelsten Scheid
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10.1371/journal.pgen.1004226

PLOS Genetics The Functional Consequences of Variation in Transcription Factor Binding
March 6, 2014 Darren A. Cusanovich, Bryan Pavlovic, Jonathan K. Pritchard, Yoav Gilad
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10.1371/journal.pgen.1004502

PLOS Genetics Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease
July 17, 2014 Ville-Petteri Mäkinen, Mete Civelek, Qingying Meng, Bin Zhang, Jun Zhu, Candace Levian, Tianxiao Huan, Ayellet V. Segrè, Sujoy Ghosh, Juan Vivar, Majid Nikpay, Alexandre F. R. Stewart, Christopher P. Nelson, Christina Willenborg, Jeanette Erdmann, Stefan Blakenberg, Christopher J. O'Donnell, Winfried März, Reijo Laaksonen, Stephen E. Epstein, Sekar Kathiresan, Svati H. Shah, Stanley L. Hazen, Muredach P. Reilly, the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium , Aldons J. Lusis, Nilesh J. Samani, Heribert Schunkert, Thomas Quertermous, Ruth McPherson, Themistocles L. Assimes, Xia Yang
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10.1371/journal.pgen.1004654

PLOS Genetics Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ
October 2, 2014 Matthew J. Yousefzadeh, David W. Wyatt, Kei-ichi Takata, Yunxiang Mu, Sean C. Hensley, Junya Tomida, Göran O. Bylund, Sylvie Doublié, Erik Johansson, Dale A. Ramsden, Kevin M. McBride, Richard D. Wood
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10.1371/journal.pgen.1004288

PLOS Genetics Genome-Wide Profiling of Yeast DNA:RNA Hybrid Prone Sites with DRIP-Chip
April 17, 2014 Yujia A. Chan, Maria J. Aristizabal, Phoebe Y. T. Lu, Zongli Luo, Akil Hamza, Michael S. Kobor, Peter C. Stirling, Philip Hieter
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10.1371/journal.pgen.1004271

PLOS Genetics Changes in Colorectal Carcinoma Genomes under Anti-EGFR Therapy Identified by Whole-Genome Plasma DNA Sequencing
March 27, 2014 Sumitra Mohan, Ellen Heitzer, Peter Ulz, Ingrid Lafer, Sigurd Lax, Martina Auer, Martin Pichler, Armin Gerger, Florian Eisner, Gerald Hoefler, Thomas Bauernhofer, Jochen B. Geigl, Michael R. Speicher
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10.1371/journal.pgen.1004787

PLOS Genetics GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation
November 13, 2014 Dongjun Chung, Can Yang, Cong Li, Joel Gelernter, Hongyu Zhao
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10.1371/journal.pgen.1004227

PLOS Genetics Epigenetic Control of Effector Gene Expression in the Plant Pathogenic Fungus Leptosphaeria maculans
March 6, 2014 Jessica L. Soyer, Mennat El Ghalid, Nicolas Glaser, Bénédicte Ollivier, Juliette Linglin, Jonathan Grandaubert, Marie-Hélène Balesdent, Lanelle R. Connolly, Michael Freitag, Thierry Rouxel, Isabelle Fudal
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10.1371/journal.pgen.1004198

PLOS Genetics A Multi-Trait, Meta-analysis for Detecting Pleiotropic Polymorphisms for Stature, Fatness and Reproduction in Beef Cattle
March 27, 2014 Sunduimijid Bolormaa, Jennie E. Pryce, Antonio Reverter, Yuandan Zhang, William Barendse, Kathryn Kemper, Bruce Tier, Keith Savin, Ben J. Hayes, Michael E. Goddard
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10.1371/journal.pgen.1004517

PLOS Genetics Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes
August 7, 2014 Maggie C. Y. Ng, Daniel Shriner, Brian H. Chen, Jiang Li, Wei-Min Chen, Xiuqing Guo, Jiankang Liu, Suzette J. Bielinski, Lisa R. Yanek, Michael A. Nalls, Mary E. Comeau, Laura J. Rasmussen-Torvik, Richard A. Jensen, Daniel S. Evans, Yan V. Sun, Ping An, Sanjay R. Patel, Yingchang Lu, Jirong Long, Loren L. Armstrong, Lynne Wagenknecht, Lingyao Yang, Beverly M. Snively, Nicholette D. Palmer, Poorva Mudgal, Carl D. Langefeld, Keith L. Keene, Barry I. Freedman, Josyf C. Mychaleckyj, Uma Nayak, Leslie J. Raffel, Mark O. Goodarzi, Y-D Ida Chen, Herman A. Taylor Jr., Adolfo Correa, Mario Sims, David Couper, James S. Pankow, Eric Boerwinkle, Adebowale Adeyemo, Ayo Doumatey, Guanjie Chen, Rasika A. Mathias, Dhananjay Vaidya, Andrew B. Singleton, Alan B. Zonderman, Robert P. Igo Jr., John R. Sedor, the FIND Consortium , Edmond K. Kabagambe, David S. Siscovick, Barbara McKnight, Kenneth Rice, Yongmei Liu, Wen-Chi Hsueh, Wei Zhao, Lawrence F. Bielak, Aldi Kraja, Michael A. Province, Erwin P. Bottinger, Omri Gottesman, Qiuyin Cai, Wei Zheng, William J. Blot, William L. Lowe, Jennifer A. Pacheco, Dana C. Crawford, the eMERGE Consortium , the DIAGRAM Consortium , Elin Grundberg, the MuTHER Consortium , Stephen S. Rich, M. Geoffrey Hayes, Xiao-Ou Shu, Ruth J. F. Loos, Ingrid B. Borecki, Patricia A. Peyser, Steven R. Cummings, Bruce M. Psaty, Myriam Fornage, Sudha K. Iyengar, Michele K. Evans, Diane M. Becker, W. H. Linda Kao, James G. Wilson, Jerome I. Rotter, Michèle M. Sale, Simin Liu, Charles N. Rotimi, Donald W. Bowden, for the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium
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10.1371/journal.pgen.1004410

PLOS Genetics Speciation and Introgression between Mimulus nasutus and Mimulus guttatus
June 26, 2014 Yaniv Brandvain, Amanda M. Kenney, Lex Flagel, Graham Coop, Andrea L. Sweigart
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10.1371/journal.pgen.1004275

PLOS Genetics Interplay of the Serine/Threonine-Kinase StkP and the Paralogs DivIVA and GpsB in Pneumococcal Cell Elongation and Division
April 10, 2014 Aurore Fleurie, Sylvie Manuse, Chao Zhao, Nathalie Campo, Caroline Cluzel, Jean-Pierre Lavergne, Céline Freton, Christophe Combet, Sébastien Guiral, Boumediene Soufi, Boris Macek, Erkin Kuru, Michael S. VanNieuwenhze, Yves V. Brun, Anne-Marie Di Guilmi, Jean-Pierre Claverys, Anne Galinier, Christophe Grangeasse
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10.1371/journal.pgen.1004102

PLOS Genetics Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci
January 30, 2014 Dennis J. Hazelett, Suhn Kyong Rhie, Malaina Gaddis, Chunli Yan, Daniel L. Lakeland, Simon G. Coetzee, Ellipse/GAME-ON consortium , Practical consortium , Brian E. Henderson, Houtan Noushmehr, Wendy Cozen, Zsofia Kote-Jarai, Rosalind A. Eeles, Douglas F. Easton, Christopher A. Haiman, Wange Lu, Peggy J. Farnham, Gerhard A. Coetzee
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10.1371/journal.pgen.1004110

PLOS Genetics NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly
February 6, 2014 Metodi Dimitrov Metodiev, Henrik Spåhr, Paola Loguercio Polosa, Caroline Meharg, Christian Becker, Janine Altmueller, Bianca Habermann, Benedetta Ruzzenente, Nils-Göran Larsson
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10.1371/journal.pgen.1004294

PLOS Genetics Transcription-Associated R-Loop Formation across the Human FMR1 CGG-Repeat Region
April 17, 2014 Erick W. Loomis, Lionel A. Sanz, Frédéric Chédin, Paul J. Hagerman
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10.1371/journal.pgen.1004547

PLOS Genetics Comprehensive Identification of Single Nucleotide Polymorphisms Associated with Beta-lactam Resistance within Pneumococcal Mosaic Genes
August 7, 2014 Claire Chewapreecha, Pekka Marttinen, Nicholas J. Croucher, Susannah J. Salter, Simon R. Harris, Alison E. Mather, William P. Hanage, David Goldblatt, Francois H. Nosten, Claudia Turner, Paul Turner, Stephen D. Bentley, Julian Parkhill
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10.1371/journal.pgen.1004741

PLOS Genetics Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
November 13, 2014 Diana F. Lázaro, Eva F. Rodrigues, Ramona Langohr, Hedieh Shahpasandzadeh, Thales Ribeiro, Patrícia Guerreiro, Ellen Gerhardt, Katharina Kröhnert, Jochen Klucken, Marcos D. Pereira, Blagovesta Popova, Niels Kruse, Brit Mollenhauer, Silvio O. Rizzoli, Gerhard H. Braus, Karin M. Danzer, Tiago F. Outeiro
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10.1371/journal.pgen.1004235

PLOS Genetics A Central Role for GRB10 in Regulation of Islet Function in Man
April 3, 2014 Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad B, S. Albert Salehi, Peter Almgren, Peter Osmark, Nabila Bouatia-Naji, Nils Wierup, Tove Fall, Alena Stančáková, Adam Barker, Vasiliki Lagou, Clive Osmond, Weijia Xie, Jari Lahti, Anne U. Jackson, Yu-Ching Cheng, Jie Liu, Jeffrey R. O'Connell, Paul A. Blomstedt, Joao Fadista, Sami Alkayyali, Tasnim Dayeh, Emma Ahlqvist, Jalal Taneera, Cecile Lecoeur, Ashish Kumar, Ola Hansson, Karin Hansson, Benjamin F. Voight, Hyun Min Kang, Claire Levy-Marchal, Vincent Vatin, Aarno Palotie, Ann-Christine Syvänen, Andrea Mari, Michael N. Weedon, Ruth J. F. Loos, Ken K. Ong, Peter Nilsson, Bo Isomaa, Tiinamaija Tuomi, Nicholas J. Wareham, Michael Stumvoll, Elisabeth Widen, Timo A. Lakka, Claudia Langenberg, Anke Tönjes, Rainer Rauramaa, Johanna Kuusisto, Timothy M. Frayling, Philippe Froguel, Mark Walker, Johan G. Eriksson, Charlotte Ling, Peter Kovacs, Erik Ingelsson, Mark I. McCarthy, Alan R. Shuldiner, Kristi D. Silver, Markku Laakso, Leif Groop, Valeriya Lyssenko
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10.1371/journal.pgen.1004091

PLOS Genetics Arabidopsis AL PHD-PRC1 Complexes Promote Seed Germination through H3K4me3-to-H3K27me3 Chromatin State Switch in Repression of Seed Developmental Genes
January 23, 2014 Anne Marie Molitor, Zhongyuan Bu, Yu Yu, Wen-Hui Shen
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10.1371/journal.pgen.1004735

PLOS Genetics Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets
November 6, 2014 Anders H. Olsson, Petr Volkov, Karl Bacos, Tasnim Dayeh, Elin Hall, Emma A. Nilsson, Claes Ladenvall, Tina Rönn, Charlotte Ling
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10.1371/journal.pgen.1004191

PLOS Genetics Telomere Shortening Unrelated to Smoking, Body Weight, Physical Activity, and Alcohol Intake: 4,576 General Population Individuals with Repeat Measurements 10 Years Apart
March 13, 2014 Maren Weischer, Stig E. Bojesen, Børge G. Nordestgaard
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10.1371/journal.pgen.1004224

PLOS Genetics Modeling 3D Facial Shape from DNA
March 20, 2014 Peter Claes, Denise K. Liberton, Katleen Daniels, Kerri Matthes Rosana, Ellen E. Quillen, Laurel N. Pearson, Brian McEvoy, Marc Bauchet, Arslan A. Zaidi, Wei Yao, Hua Tang, Gregory S. Barsh, Devin M. Absher, David A. Puts, Jorge Rocha, Sandra Beleza, Rinaldo W. Pereira, Gareth Baynam, Paul Suetens, Dirk Vandermeulen, Jennifer K. Wagner, James S. Boster, Mark D. Shriver
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10.1371/journal.pgen.1004342

PLOS Genetics Genome-Wide Inference of Ancestral Recombination Graphs
May 15, 2014 Matthew D. Rasmussen, Melissa J. Hubisz, Ilan Gronau, Adam Siepel
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10.1371/journal.pgen.1004243

PLOS Genetics The Membrane-Associated Transcription Factor NAC089 Controls ER-Stress-Induced Programmed Cell Death in Plants
March 27, 2014 Zheng-Ting Yang, Mei-Jing Wang, Ling Sun, Sun-Jie Lu, Dong-Ling Bi, Le Sun, Ze-Ting Song, Shuang-Shuang Zhang, Shun-Fan Zhou, Jian-Xiang Liu
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10.1371/journal.pgen.1004596

PLOS Genetics Hidden Diversity in Honey Bee Gut Symbionts Detected by Single-Cell Genomics
September 11, 2014 Philipp Engel, Ramunas Stepanauskas, Nancy A. Moran
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10.1371/journal.pgen.1004716

PLOS Genetics Genome-Wide Distribution of RNA-DNA Hybrids Identifies RNase H Targets in tRNA Genes, Retrotransposons and Mitochondria
October 30, 2014 Aziz El Hage, Shaun Webb, Alastair Kerr, David Tollervey
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10.1371/journal.pgen.1004354

PLOS Genetics G×G×E for Lifespan in Drosophila: Mitochondrial, Nuclear, and Dietary Interactions that Modify Longevity
May 15, 2014 Chen-Tseh Zhu, Paul Ingelmo, David M. Rand
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10.1371/journal.pgen.1004347

PLOS Genetics Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification
May 1, 2014 Christoph Ruckenstuhl, Christine Netzberger, Iryna Entfellner, Didac Carmona-Gutierrez, Thomas Kickenweiz, Slaven Stekovic, Christina Gleixner, Christian Schmid, Lisa Klug, Alice G. Sorgo, Tobias Eisenberg, Sabrina Büttner, Guillermo Mariño, Rafal Koziel, Pidder Jansen-Dürr, Kai-Uwe Fröhlich, Guido Kroemer, Frank Madeo
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10.1371/journal.pgen.1004766

PLOS Genetics Plasmid Flux in Escherichia coli ST131 Sublineages, Analyzed by Plasmid Constellation Network (PLACNET), a New Method for Plasmid Reconstruction from Whole Genome Sequences
December 18, 2014 Val F. Lanza, María de Toro, M. Pilar Garcillán-Barcia, Azucena Mora, Jorge Blanco, Teresa M. Coque, Fernando de la Cruz
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10.1371/journal.pgen.1004556

PLOS Genetics Memory and Fitness Optimization of Bacteria under Fluctuating Environments
September 25, 2014 Guillaume Lambert, Edo Kussell
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10.1371/journal.pgen.1004525

PLOS Genetics 8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage
July 24, 2014 Chris M. Rands, Stephen Meader, Chris P. Ponting, Gerton Lunter
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10.1371/journal.pgen.1004785

PLOS Genetics Evolution of DNA Methylation Patterns in the Brassicaceae is Driven by Differences in Genome Organization
November 13, 2014 Danelle K. Seymour, Daniel Koenig, Jörg Hagmann, Claude Becker, Detlef Weigel
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10.1371/journal.pgen.1004182

PLOS Genetics The First Steps of Adaptation of Escherichia coli to the Gut Are Dominated by Soft Sweeps
March 6, 2014 João Barroso-Batista, Ana Sousa, Marta Lourenço, Marie-Louise Bergman, Daniel Sobral, Jocelyne Demengeot, Karina B. Xavier, Isabel Gordo
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10.1371/journal.pgen.1004173

PLOS Genetics Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses
February 20, 2014 Kristina Ibáñez, César Boullosa, Rafael Tabarés-Seisdedos, Anaïs Baudot, Alfonso Valencia
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10.1371/journal.pgen.1004406

PLOS Genetics Microbial Succession in the Gut: Directional Trends of Taxonomic and Functional Change in a Birth Cohort of Spanish Infants
June 5, 2014 Yvonne Vallès, Alejandro Artacho, Alberto Pascual-García, Maria Loreto Ferrús, María José Gosalbes, Juan José Abellán, M. Pilar Francino
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10.1371/journal.pgen.1004075

PLOS Genetics Evidence for Mito-Nuclear and Sex-Linked Reproductive Barriers between the Hybrid Italian Sparrow and Its Parent Species
January 9, 2014 Cassandra N. Trier, Jo S. Hermansen, Glenn-Peter Sætre, Richard I. Bailey
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10.1371/journal.pgen.1004566

PLOS Genetics Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation
September 4, 2014 Relja Popovic, Eva Martinez-Garcia, Eugenia G. Giannopoulou, Quanwei Zhang, Qingyang Zhang, Teresa Ezponda, Mrinal Y. Shah, Yupeng Zheng, Christine M. Will, Eliza C. Small, Youjia Hua, Marinka Bulic, Yanwen Jiang, Matteo Carrara, Raffaele A. Calogero, William L. Kath, Neil L. Kelleher, Ji-Ping Wang, Olivier Elemento, Jonathan D. Licht
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10.1371/journal.pgen.1004423

PLOS Genetics Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment
June 19, 2014 John P. Kemp, Carolina Medina-Gomez, Karol Estrada, Beate St Pourcain, Denise H. M. Heppe, Nicole M. Warrington, Ling Oei, Susan M. Ring, Claudia J. Kruithof, Nicholas J. Timpson, Lisa E. Wolber, Sjur Reppe, Kaare Gautvik, Elin Grundberg, Bing Ge, Bram van der Eerden, Jeroen van de Peppel, Matthew A. Hibbs, Cheryl L. Ackert-Bicknell, Kwangbom Choi, Daniel L. Koller, Michael J. Econs, Frances M. K. Williams, Tatiana Foroud, M. Carola Zillikens, Claes Ohlsson, Albert Hofman, André G. Uitterlinden, George Davey Smith, Vincent W. V. Jaddoe, Jonathan H. Tobias, Fernando Rivadeneira, David M. Evans
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10.1371/journal.pgen.1004379

PLOS Genetics The Impact of Population Demography and Selection on the Genetic Architecture of Complex Traits
May 29, 2014 Kirk E. Lohmueller
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10.1371/journal.pgen.1004440

PLOS Genetics Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression
June 19, 2014 Elisabeth Sonnleitner, Udo Bläsi
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10.1371/journal.pgen.1004593

PLOS Genetics The Olfactory Transcriptomes of Mice
September 4, 2014 Ximena Ibarra-Soria, Maria O. Levitin, Luis R. Saraiva, Darren W. Logan
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10.1371/journal.pgen.1004289

PLOS Genetics The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing
April 10, 2014 Feng-Yang Zong, Xing Fu, Wen-Juan Wei, Ya-Ge Luo, Monika Heiner, Li-Juan Cao, Zhaoyuan Fang, Rong Fang, Daru Lu, Hongbin Ji, Jingyi Hui
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10.1371/journal.pgen.1004158

PLOS Genetics Genome-Wide DNA Methylation Analysis Predicts an Epigenetic Switch for GATA Factor Expression in Endometriosis
March 6, 2014 Matthew T. Dyson, Damian Roqueiro, Diana Monsivais, C. Mutlu Ercan, Mary Ellen Pavone, David C. Brooks, Toshiyuki Kakinuma, Masanori Ono, Nadereh Jafari, Yang Dai, Serdar E. Bulun
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10.1371/journal.pgen.1004123

PLOS Genetics Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease
February 27, 2014 Marco Medici, Eleonora Porcu, Giorgio Pistis, Alexander Teumer, Suzanne Brown, Richard Jensen, Rajesh Rawal, Greet Roef, Theo Plantinga, Sita Vermeulen, Jari Lahti, Matthew Simmonds, Lise Lotte Husemoen, Rachel Freathy, Beverley Shields, Diana Pietzner, Rebecca Nagy, Linda Broer, Layal Chaker, Tim Korevaar, Maria Grazia Plia, Cinzia Sala, Uwe Völker, J Brent Richards, Fred Sweep, Christian Gieger, Tanguy Corre, Eero Kajantie, Betina Thuesen, Youri Taes, W Edward Visser, Andrew Hattersley, Jürgen Kratzsch, Alexander Hamilton, Wei Li, Georg Homuth, Monia Lobina, Stefano Mariotti, Nicole Soranzo, Massimiliano Cocca, Matthias Nauck, Christin Spielhagen, Alec Ross, Alice Arnold, Martijn van de Bunt, Sandya Liyanarachchi, Margit Heier, Hans Jörgen Grabe, Corrado Masciullo, Tessel Galesloot, Ee Lim, Eva Reischl, Peter Leedman, Sandra Lai, Alessandro Delitala, Alexandra Bremner, David Philips, John Beilby, Antonella Mulas, Matteo Vocale, Goncalo Abecasis, Tom Forsen, Alan James, Elisabeth Widen, Jennie Hui, Holger Prokisch, Ernst Rietzschel, Aarno Palotie, Peter Feddema, Stephen Fletcher, Katharina Schramm, Jerome Rotter, Alexander Kluttig, Dörte Radke, Michela Traglia, Gabriela Surdulescu, Huiling He, Jayne Franklyn, Daniel Tiller, Bijay Vaidya, Tim de Meyer, Torben Jørgensen, Johan Eriksson, Peter O'Leary, Eric Wichmann, Ad Hermus, Bruce Psaty, Till Ittermann, Albert Hofman, Emanuele Bosi, David Schlessinger, Henri Wallaschofski, Nicola Pirastu, Yurii Aulchenko, Albert de la Chapelle, Romana Netea-Maier, Stephen Gough, Henriette Meyer zu Schwabedissen, Timothy Frayling, Jean-Marc Kaufman, Allan Linneberg, Katri Räikkönen, Johannes Smit, Lambertus Kiemeney, Fernando Rivadeneira, André Uitterlinden, John Walsh, Christa Meisinger, Martin den Heijer, Theo Visser, Timothy Spector, Scott Wilson, Henry Völzke, Anne Cappola, Daniela Toniolo, Serena Sanna, Silvia Naitza, Robin Peeters

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