Biology & Life Sciences

PLOS Pathogens Top 10%

Published July 30, 2020 Curated Collections

At PLOS Pathogens we publish outstanding research on pathogenic organisms including bacteria, fungi, parasites, prions and viruses. Each year, we celebrate the impact our authors have had and share out the body of work that has earned the top 10% of citations. We hope you enjoy exploring this Collection.

Image Credit: Somdeb BoseDasgupta and Jean Pieters in collaboration with the Center for Microscopy, University of Basel

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2018

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10.1371/journal.ppat.1006815

PLOS Pathogens The Wolbachia strain wAu provides highly efficient virus transmission blocking in Aedes aegypti
January 25, 2018 Thomas H. Ant, Christie S. Herd, Vincent Geoghegan, Ary A. Hoffmann, Steven P. Sinkins
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10.1371/journal.ppat.1006798

PLOS Pathogens Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children
January 18, 2018 Marianne S. Muhlebach, Bryan T. Zorn, Charles R. Esther, Joseph E. Hatch, Conor P. Murray, Lidija Turkovic, Sarath C. Ranganathan, Richard C. Boucher, Stephen M. Stick, Matthew C. Wolfgang
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10.1371/journal.ppat.1006994

PLOS Pathogens Zika virus infection in immunocompetent pregnant mice causes fetal damage and placental pathology in the absence of fetal infection
April 10, 2018 Frank M. Szaba, Michael Tighe, Lawrence W. Kummer, Kathleen G. Lanzer, Jerrold M. Ward, Paula Lanthier, In-Jeong Kim, Atsuo Kuki, Marcia A. Blackman, Stephen J. Thomas, Jr-Shiuan Lin
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10.1371/journal.ppat.1006919

PLOS Pathogens Addition of m⁶A to SV40 late mRNAs enhances viral structural gene expression and replication
February 15, 2018 Kevin Tsai, David G. Courtney, Bryan R. Cullen
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10.1371/journal.ppat.1007084

PLOS Pathogens Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens
June 21, 2018 Daniel Pletzer, Sarah C. Mansour, Robert E. W. Hancock
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10.1371/journal.ppat.1006792

PLOS Pathogens Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals
January 11, 2018 Katherine E. Clarridge, Jana Blazkova, Kevin Einkauf, Mary Petrone, Eric W. Refsland, J. Shawn Justement, Victoria Shi, Erin D. Huiting, Catherine A. Seamon, Guinevere Q. Lee, Xu G. Yu, Susan Moir, Michael C. Sneller, Mathias Lichterfeld, Tae-Wook Chun
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10.1371/journal.ppat.1006978

PLOS Pathogens The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis
May 18, 2018 Ivy M. Dambuza, Thomas Drake, Ambre Chapuis, Xin Zhou, Joao Correia, Leanne Taylor-Smith, Nathalie LeGrave, Tim Rasmussen, Matthew C. Fisher, Tihana Bicanic, Thomas S. Harrison, Marcel Jaspars, Robin C. May, Gordon D. Brown, Raif Yuecel, Donna M. MacCallum, Elizabeth R. Ballou
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10.1371/journal.ppat.1006811

PLOS Pathogens Indole-3-acetaldehyde dehydrogenase-dependent auxin synthesis contributes to virulence of Pseudomonas syringae strain DC3000
January 2, 2018 Sheri A. McClerklin, Soon Goo Lee, Christopher P. Harper, Ron Nwumeh, Joseph M. Jez, Barbara N. Kunkel
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10.1371/journal.ppat.1006874

PLOS Pathogens Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense
January 25, 2018 Matthew Knight, Jonathan Braverman, Kaleb Asfaha, Karsten Gronert, Sarah Stanley
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10.1371/journal.ppat.1006982

PLOS Pathogens Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators
May 18, 2018 Benjamin Hommel, Liliane Mukaremera, Radames J. B. Cordero, Carolina Coelho, Christopher A. Desjardins, Aude Sturny-Leclère, Guilhem Janbon, John R. Perfect, James A. Fraser, Arturo Casadevall, Christina A. Cuomo, Françoise Dromer, Kirsten Nielsen, Alexandre Alanio
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10.1371/journal.ppat.1006790

PLOS Pathogens Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells
January 4, 2018 Marilena P. Etna, Alessandro Sinigaglia, Angela Grassi, Elena Giacomini, Alessandra Romagnoli, Manuela Pardini, Martina Severa, Melania Cruciani, Fabiana Rizzo, Eleni Anastasiadou, Barbara Di Camillo, Luisa Barzon, Gian Maria Fimia, Riccardo Manganelli, Eliana M. Coccia
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10.1371/journal.ppat.1007009

PLOS Pathogens Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins
April 23, 2018 Jian Shang, Yuan Zheng, Yang Yang, Chang Liu, Qibin Geng, Chuming Luo, Wei Zhang, Fang Li
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10.1371/journal.ppat.1006946

PLOS Pathogens Evolution of structural diversity of trichothecenes, a family of toxins produced by plant pathogenic and entomopathogenic fungi
April 12, 2018 Robert H. Proctor, Susan P. McCormick, Hye-Seon Kim, Rosa E. Cardoza, April M. Stanley, Laura Lindo, Amy Kelly, Daren W. Brown, Theresa Lee, Martha M. Vaughan, Nancy J. Alexander, Mark Busman, Santiago Gutiérrez
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10.1371/journal.ppat.1006898

PLOS Pathogens CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection
March 8, 2018 Yuemei Dong, Maria L. Simões, Eric Marois, George Dimopoulos
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10.1371/journal.ppat.1007236

PLOS Pathogens Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
August 13, 2018 Wenfei Song, Miao Gui, Xinquan Wang, Ye Xiang
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10.1371/journal.ppat.1006913

PLOS Pathogens Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques
February 23, 2018 P. J. Klasse, Thomas J. Ketas, Christopher A. Cottrell, Gabriel Ozorowski, Gargi Debnath, Diawoye Camara, Erik Francomano, Pavel Pugach, Rajesh P. Ringe, Celia C. LaBranche, Marit J. van Gils, Christine A. Bricault, Dan H. Barouch, Shane Crotty, Guido Silvestri, Sudhir Kasturi, Bali Pulendran, Ian A. Wilson, David C. Montefiori, Rogier W. Sanders, Andrew B. Ward, John P. Moore
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10.1371/journal.ppat.1006764

PLOS Pathogens Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cells
January 4, 2018 Wenshuo Zhou, Michael Woodson, Biswas Neupane, Fengwei Bai, Michael B. Sherman, Kyung H. Choi, Girish Neelakanta, Hameeda Sultana
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10.1371/journal.ppat.1006810

PLOS Pathogens Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection
January 2, 2018 Megan E. Schmidt, Cory J. Knudson, Stacey M. Hartwig, Lecia L. Pewe, David K. Meyerholz, Ryan A. Langlois, John T. Harty, Steven M. Varga
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10.1371/journal.ppat.1006995

PLOS Pathogens N⁶-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi’s sarcoma-associated herpesvirus infection
April 16, 2018 Charles R. Hesser, John Karijolich, Dan Dominissini, Chuan He, Britt A. Glaunsinger
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10.1371/journal.ppat.1007007

PLOS Pathogens Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
May 18, 2018 Nuria Trevijano-Contador, Haroldo Cesar de Oliveira, Rocío García-Rodas, Suélen Andreia Rossi, Irene Llorente, Ángel Zaballos, Guilhem Janbon, Joaquín Ariño, Óscar Zaragoza
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10.1371/journal.ppat.1006987

PLOS Pathogens HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies
April 9, 2018 Simone I. Richardson, Amy W. Chung, Harini Natarajan, Batsirai Mabvakure, Nonhlanhla N. Mkhize, Nigel Garrett, Salim Abdool Karim, Penny L. Moore, Margaret E. Ackerman, Galit Alter, Lynn Morris
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10.1371/journal.ppat.1006930

PLOS Pathogens Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites
March 14, 2018 Frances Rocamora, Lei Zhu, Kek Yee Liong, Arjen Dondorp, Olivo Miotto, Sachel Mok, Zbynek Bozdech
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10.1371/journal.ppat.1006860

PLOS Pathogens Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections
March 5, 2018 Kshitij Wagh, Michael S. Seaman, Marshall Zingg, Tomas Fitzsimons, Dan H. Barouch, Dennis R. Burton, Mark Connors, David D. Ho, John R. Mascola, Michel C. Nussenzweig, Jeffrey Ravetch, Rajeev Gautam, Malcolm A. Martin, David C. Montefiori, Bette Korber
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10.1371/journal.ppat.1006965

PLOS Pathogens Contributions from the silent majority dominate dengue virus transmission
May 3, 2018 Quirine A. ten Bosch, Hannah E. Clapham, Louis Lambrechts, Veasna Duong, Philippe Buchy, Benjamin M. Althouse, Alun L. Lloyd, Lance A. Waller, Amy C. Morrison, Uriel Kitron, Gonzalo M. Vazquez-Prokopec, Thomas W. Scott, T. Alex Perkins
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10.1371/journal.ppat.1006856

PLOS Pathogens Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4⁺ T cells expressing CD30
February 22, 2018 Louise E. Hogan, Joshua Vasquez, Kristen S. Hobbs, Emily Hanhauser, Brandon Aguilar-Rodriguez, Rajaa Hussien, Cassandra Thanh, Erica A. Gibson, Alexander B. Carvidi, Louis C. B. Smith, Shahzada Khan, Martin Trapecar, Shomyseh Sanjabi, Ma Somsouk, Cheryl A. Stoddart, Daniel R. Kuritzkes, Steven G. Deeks, Timothy J. Henrich
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10.1371/journal.ppat.1006756

PLOS Pathogens A role for small RNA in regulating innate immunity during plant growth
January 2, 2018 Yingtian Deng, Jubin Wang, Jeffrey Tung, Dan Liu, Yingjia Zhou, Shuang He, Yunlian Du, Barbara Baker, Feng Li
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10.1371/journal.ppat.1006769

PLOS Pathogens Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection
January 8, 2018 Thamir Alandijany, Ashley P. E. Roberts, Kristen L. Conn, Colin Loney, Steven McFarlane, Anne Orr, Chris Boutell
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10.1371/journal.ppat.1006828

PLOS Pathogens Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii
January 22, 2018 Nicole D. Marino, Michael W. Panas, Magdalena Franco, Terence C. Theisen, Adit Naor, Suchita Rastogi, Kerry R. Buchholz, Hernan A. Lorenzi, John C. Boothroyd
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10.1371/journal.ppat.1007251

PLOS Pathogens Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection
November 5, 2018 Yong-Yao Yu, Weiguang Kong, Ya-Xing Yin, Fen Dong, Zhen-Yu Huang, Guang-Mei Yin, Shuai Dong, Irene Salinas, Yong-An Zhang, Zhen Xu
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10.1371/journal.ppat.1007206

PLOS Pathogens The Epstein Barr virus circRNAome
August 6, 2018 Nathan Ungerleider, Monica Concha, Zhen Lin, Claire Roberts, Xia Wang, Subing Cao, Melody Baddoo, Walter N. Moss, Yi Yu, Michael Seddon, Terri Lehman, Scott Tibbetts, Rolf Renne, Yan Dong, Erik K. Flemington
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10.1371/journal.ppat.1006827

PLOS Pathogens The fungal myosin I is essential for Fusarium toxisome formation
January 22, 2018 Guangfei Tang, Yun Chen, Jin-Rong Xu, H. Corby Kistler, Zhonghua Ma
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10.1371/journal.ppat.1006750

PLOS Pathogens The paradox of HBV evolution as revealed from a 16^th century mummy
January 4, 2018 Zoe Patterson Ross, Jennifer Klunk, Gino Fornaciari, Valentina Giuffra, Sebastian Duchêne, Ana T. Duggan, Debi Poinar, Mark W. Douglas, John-Sebastian Eden, Edward C. Holmes, Hendrik N. Poinar
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10.1371/journal.ppat.1007237

PLOS Pathogens CD4⁺T cells mediate protection against Zika associated severe disease in a mouse model of infection
September 13, 2018 Mariah Hassert, Kyle J. Wolf, Katherine E. Schwetye, Richard J. DiPaolo, James D. Brien, Amelia K. Pinto
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10.1371/journal.ppat.1007233

PLOS Pathogens Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces
August 13, 2018 Hongbo Guo, Huib Rabouw, Anne Slomp, Meiling Dai, Floor van der Vegt, Jan W. M. van Lent, Ryan McBride, James C. Paulson, Raoul J. de Groot, Frank J. M. van Kuppeveld, Erik de Vries, Cornelis A. M. de Haan
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10.1371/journal.ppat.1006885

PLOS Pathogens When are pathogen genome sequences informative of transmission events?
February 8, 2018 Finlay Campbell, Camilla Strang, Neil Ferguson, Anne Cori, Thibaut Jombart
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10.1371/journal.ppat.1007159

PLOS Pathogens Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV
July 5, 2018 Adam S. Dingens, Priyamvada Acharya, Hugh K. Haddox, Reda Rawi, Kai Xu, Gwo-Yu Chuang, Hui Wei, Baoshan Zhang, John R. Mascola, Bridget Carragher, Clinton S. Potter, Julie Overbaugh, Peter D. Kwong, Jesse D. Bloom
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10.1371/journal.ppat.1006993

PLOS Pathogens Tissue maintenance of CMV-specific inflationary memory T cells by IL-15
April 13, 2018 Nicolas S. Baumann, Nicole Torti, Suzanne P. M. Welten, Isabel Barnstorf, Mariana Borsa, Katharina Pallmer, Jennifer D. Oduro, Luka Cicin-Sain, Koichi Ikuta, Burkhard Ludewig, Annette Oxenius
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10.1371/journal.ppat.1007191

PLOS Pathogens Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria
September 12, 2018 Ian J. Passmore, Marine P. M. Letertre, Mark D. Preston, Irene Bianconi, Mark A. Harrison, Fauzy Nasher, Harparkash Kaur, Huynh A. Hong, Simon D. Baines, Simon M. Cutting, Jonathan R. Swann, Brendan W. Wren, Lisa F. Dawson
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10.1371/journal.ppat.1007112

PLOS Pathogens Staphylococcus aureus infection dynamics
June 14, 2018 Eric J. G. Pollitt, Piotr T. Szkuta, Nicola Burns, Simon J. Foster
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10.1371/journal.ppat.1006835

PLOS Pathogens Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes
January 29, 2018 Michela Mazzon, Cecilia Castro, Bastian Thaa, Lifeng Liu, Margit Mutso, Xiang Liu, Suresh Mahalingam, Julian L. Griffin, Mark Marsh, Gerald M. McInerney
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10.1371/journal.ppat.1006847

PLOS Pathogens Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogaster
February 2, 2018 Katia Troha, Joo Hyun Im, Jonathan Revah, Brian P. Lazzaro, Nicolas Buchon
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10.1371/journal.ppat.1006796

PLOS Pathogens Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs
January 18, 2018 Ivan Kosik, William L. Ince, Lauren E. Gentles, Andrew J. Oler, Martina Kosikova, Matthew Angel, Javier G. Magadán, Hang Xie, Christopher B. Brooke, Jonathan W. Yewdell
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10.1371/journal.ppat.1006838

PLOS Pathogens MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection
January 25, 2018 Javier Canton, Anthony R. Fehr, Raúl Fernandez-Delgado, Francisco J. Gutierrez-Alvarez, Maria T. Sanchez-Aparicio, Adolfo García-Sastre, Stanley Perlman, Isabel Sola, Luis Enjuanes
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10.1371/journal.ppat.1007144

PLOS Pathogens Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH
June 15, 2018 Man Shun Fu, Carolina Coelho, Carlos M. De Leon-Rodriguez, Diego C. P. Rossi, Emma Camacho, Eric H. Jung, Madhura Kulkarni, Arturo Casadevall
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10.1371/journal.ppat.1006889

PLOS Pathogens Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase
February 9, 2018 Paul C. Jordan, Cheng Liu, Pauline Raynaud, Michael K. Lo, Christina F. Spiropoulou, Julian A. Symons, Leo Beigelman, Jerome Deval
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10.1371/journal.ppat.1006914

PLOS Pathogens Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor
March 9, 2018 Nicole Stichling, Maarit Suomalainen, Justin W. Flatt, Markus Schmid, Martin Pacesa, Silvio Hemmi, Wolfgang Jungraithmayr, Mareike D. Maler, Marina A. Freudenberg, Andreas Plückthun, Tobias May, Mario Köster, György Fejer, Urs F. Greber
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10.1371/journal.ppat.1007109

PLOS Pathogens RNAi screening identifies a new Toll from shrimp Litopenaeus vannamei that restricts WSSV infection through activating Dorsal to induce antimicrobial peptides
September 26, 2018 Haoyang Li, Bin Yin, Sheng Wang, Qihui Fu, Bang Xiao, Kai Lǚ, Jianguo He, Chaozheng Li
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10.1371/journal.ppat.1006935

PLOS Pathogens Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies
March 6, 2018 Harrison G. Jones, Tina Ritschel, Gabriel Pascual, Just P. J. Brakenhoff, Elissa Keogh, Polina Furmanova-Hollenstein, Ellen Lanckacker, Jehangir S. Wadia, Morgan S. A. Gilman, R. Anthony Williamson, Dirk Roymans, Angélique B. van ‘t Wout, Johannes P. Langedijk, Jason S. McLellan
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10.1371/journal.ppat.1007035

PLOS Pathogens Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis
May 2, 2018 Joshua B. Radke, Danielle Worth, David Hong, Sherri Huang, William J. Sullivan Jr., Emma H. Wilson, Michael W. White

2017

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10.1371/journal.ppat.1006407

PLOS Pathogens Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo
June 15, 2017 Geelsu Hwang, Yuan Liu, Dongyeop Kim, Yong Li, Damian J. Krysan, Hyun Koo
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10.1371/journal.ppat.1006514

PLOS Pathogens Helicobacter pylori modulates host cell responses by CagT4SS-dependent translocation of an intermediate metabolite of LPS inner core heptose biosynthesis
July 17, 2017 Saskia C. Stein, Eugenia Faber, Simon H. Bats, Tatiana Murillo, Yvonne Speidel, Nina Coombs, Christine Josenhans
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10.1371/journal.ppat.1006227

PLOS Pathogens Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy
February 13, 2017 Raja Ganesan, Nina Judith Hos, Saray Gutierrez, Julia Fischer, Joanna Magdalena Stepek, Evmorphia Daglidu, Martin Krönke, Nirmal Robinson
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10.1371/journal.ppat.1006440

PLOS Pathogens Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development
July 13, 2017 Ritesh Kumar, Jennifer L. Herold, Deborah Schady, Jennifer Davis, Scott Kopetz, Margarita Martinez-Moczygemba, Barbara E. Murray, Fang Han, Yu Li, Evelyn Callaway, Robert S. Chapkin, Wan-Mohaiza Dashwood, Roderick H. Dashwood, Tia Berry, Chris Mackenzie, Yi Xu
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10.1371/journal.ppat.1006006

PLOS Pathogens Wolbachia Infections in Aedes aegypti Differ Markedly in Their Response to Cyclical Heat Stress
January 5, 2017 Perran A. Ross, Itsanun Wiwatanaratanabutr, Jason K. Axford, Vanessa L. White, Nancy M. Endersby-Harshman, Ary A. Hoffmann
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10.1371/journal.ppat.1006213

PLOS Pathogens A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in Nicotiana benthamiana
February 17, 2017 Fangfang Li, Nan Zhao, Zhenghe Li, Xiongbiao Xu, Yaqin Wang, Xiuling Yang, Shu-Sheng Liu, Aiming Wang, Xueping Zhou
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10.1371/journal.ppat.1006411

PLOS Pathogens A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease
May 25, 2017 Matthew Brecher, Zhong Li, Binbin Liu, Jing Zhang, Cheri A. Koetzner, Adham Alifarag, Susan A. Jones, Qishan Lin, Laura D. Kramer, Hongmin Li
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10.1371/journal.ppat.1006199

PLOS Pathogens A mouse model of paralytic myelitis caused by enterovirus D68
February 23, 2017 Alison M. Hixon, Guixia Yu, J. Smith Leser, Shigeo Yagi, Penny Clarke, Charles Y. Chiu, Kenneth L. Tyler
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10.1371/journal.ppat.1006258

PLOS Pathogens A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses
March 9, 2017 Shashank Tripathi, Vinod Balasubramaniam, Julia Brown, Ignacio Mena, Alesha Grant, Susana Bardina, Kevin Maringer, Megan Schwarz, Ana Maestre, Marion Sourisseau, Randy Albrecht, Florian Krammer, Matthew Evans, Ana Fernandez-Sesma, Jean Lim, Adolfo García-Sastre
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10.1371/journal.ppat.1006096

PLOS Pathogens A Novel Zn₂-Cys₆ Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions
January 4, 2017 Daisuke Hagiwara, Daisuke Miura, Kiminori Shimizu, Sanjoy Paul, Ayumi Ohba, Tohru Gonoi, Akira Watanabe, Katsuhiko Kamei, Takahiro Shintani, W. Scott Moye-Rowley, Susumu Kawamoto, Katsuya Gomi
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10.1371/journal.ppat.1006267

PLOS Pathogens A quantitative brain map of experimental cerebral malaria pathology
March 8, 2017 Patrick Strangward, Michael J. Haley, Tovah N. Shaw, Jean-Marc Schwartz, Rachel Greig, Aleksandr Mironov, J. Brian de Souza, Sheena M. Cruickshank, Alister G. Craig, Danny A. Milner Jr, Stuart M. Allan, Kevin N. Couper
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10.1371/journal.ppat.1006682

PLOS Pathogens A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine
October 23, 2017 Nicholas C. Wu, Seth J. Zost, Andrew J. Thompson, David Oyen, Corwin M. Nycholat, Ryan McBride, James C. Paulson, Scott E. Hensley, Ian A. Wilson
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10.1371/journal.ppat.1006125

PLOS Pathogens A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity
January 19, 2017 Yuritzi M. Garcia, Anna Barwinska-Sendra, Emma Tarrant, Eric P. Skaar, Kevin J. Waldron, Thomas E. Kehl-Fie
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10.1371/journal.ppat.1006403

PLOS Pathogens Adaptation of Candida albicans to environmental pH induces cell wall remodelling and enhances innate immune recognition
May 22, 2017 Sarah L. Sherrington, Eleanor Sorsby, Nabeel Mahtey, Pizga Kumwenda, Megan D. Lenardon, Ian Brown, Elizabeth R. Ballou, Donna M. MacCallum, Rebecca A. Hall
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10.1371/journal.ppat.1006224

PLOS Pathogens ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria
February 21, 2017 Milica Milivojevic, Anne-Sophie Dangeard, Christoph Alexander Kasper, Therese Tschon, Mario Emmenlauer, Claudine Pique, Pamela Schnupf, Julie Guignot, Cécile Arrieumerlou
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10.1371/journal.ppat.1006184

PLOS Pathogens Analysis of the T Cell Response to Zika Virus and Identification of a Novel CD8⁺ T Cell Epitope in Immunocompetent Mice
February 23, 2017 Ryan Pardy, Maaran Rajah, Stephanie Condotta, Nathan Taylor, Selena Sagan, Martin Richer
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10.1371/journal.ppat.1006196

PLOS Pathogens CD8⁺ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production
February 13, 2017 Fernanda O. Novais, Augusto M. Carvalho, Megan L. Clark, Lucas P. Carvalho, Daniel P. Beiting, Igor E. Brodsky, Edgar M. Carvalho, Phillip Scott
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10.1371/journal.ppat.1006175

PLOS Pathogens Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma
January 17, 2017 Evelyn Santos Guerra, Chrono K. Lee, Charles A. Specht, Bhawna Yadav, Haibin Huang, Ali Akalin, Jun R. Huh, Christian Mueller, Stuart M. Levitz
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10.1371/journal.ppat.1006215

PLOS Pathogens Comparative analysis estimates the relative frequencies of co-divergence and cross-species transmission within viral families
February 8, 2017 Jemma L. Geoghegan, Sebastián Duchêne, Edward C. Holmes
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10.1371/journal.ppat.1006653

PLOS Pathogens Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use
November 2, 2017 Bryony N. Parsons, Umer Z. Ijaz, Rosalinda D’Amore, Michael D. Burkitt, Richard Eccles, Luca Lenzi, Carrie A. Duckworth, Andrew R. Moore, Laszlo Tiszlavicz, Andrea Varro, Neil Hall, D. Mark Pritchard
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10.1371/journal.ppat.1006271

PLOS Pathogens Complete mapping of viral escape from neutralizing antibodies
March 13, 2017 Michael B. Doud, Scott E. Hensley, Jesse D. Bloom
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10.1371/journal.ppat.1006265

PLOS Pathogens Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells
March 6, 2017 Claudia V. Filomatori, Juan M. Carballeda, Sergio M. Villordo, Sebastian Aguirre, Horacio M. Pallarés, Ana M. Maestre, Irma Sánchez-Vargas, Carol D. Blair, Cintia Fabri, Maria A. Morales, Ana Fernandez-Sesma, Andrea V. Gamarnik
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10.1371/journal.ppat.1006673

PLOS Pathogens Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components
November 9, 2017 Dustin R. Glasner, Kalani Ratnasiri, Henry Puerta-Guardo, Diego A. Espinosa, P. Robert Beatty, Eva Harris
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10.1371/journal.ppat.1006698

PLOS Pathogens Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus
November 30, 2017 Ben Hu, Lei-Ping Zeng, Xing-Lou Yang, Xing-Yi Ge, Wei Zhang, Bei Li, Jia-Zheng Xie, Xu-Rui Shen, Yun-Zhi Zhang, Ning Wang, Dong-Sheng Luo, Xiao-Shuang Zheng, Mei-Niang Wang, Peter Daszak, Lin-Fa Wang, Jie Cui, Zheng-Li Shi
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10.1371/journal.ppat.1006195

PLOS Pathogens Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication
February 3, 2017 Eveline Kindler, Cristina Gil-Cruz, Julia Spanier, Yize Li, Jochen Wilhelm, Huib H. Rabouw, Roland Züst, Mihyun Hwang, Philip V’kovski, Hanspeter Stalder, Sabrina Marti, Matthias Habjan, Luisa Cervantes-Barragan, Ruth Elliot, Nadja Karl, Christina Gaughan, Frank J. M. van Kuppeveld, Robert H. Silverman, Markus Keller, Burkhard Ludewig, Cornelia C. Bergmann, John Ziebuhr, Susan R. Weiss, Ulrich Kalinke, Volker Thiel
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10.1371/journal.ppat.1006250

PLOS Pathogens Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine
March 9, 2017 Rafael Prados-Rosales, Leandro Carreño, Tingting Cheng, Caroline Blanc, Brian Weinrick, Adel Malek, Todd L. Lowary, Andres Baena, Maju Joe, Yu Bai, Rainer Kalscheuer, Ana Batista-Gonzalez, Noemi A. Saavedra, Leticia Sampedro, Julen Tomás, Juan Anguita, Shang-Cheng Hung, Ashish Tripathi, Jiayong Xu, Aharona Glatman-Freedman, Williams R. Jacobs Jr., John Chan, Steven A. Porcelli, Jacqueline M. Achkar, Arturo Casadevall
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10.1371/journal.ppat.1006123

PLOS Pathogens EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex
January 6, 2017 Wenbiao Wang, Feng Xiao, Pin Wan, Pan Pan, Yecheng Zhang, Fang Liu, Kailang Wu, Yingle Liu, Jianguo Wu
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10.1371/journal.ppat.1006658

PLOS Pathogens HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
September 25, 2017 Fang Guo, Qiong Zhao, Muhammad Sheraz, Junjun Cheng, Yonghe Qi, Qing Su, Andrea Cuconati, Lai Wei, Yanming Du, Wenhui Li, Jinhong Chang, Ju-Tao Guo
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10.1371/journal.ppat.1006524

PLOS Pathogens Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs
August 24, 2017 Ohad Yogev, Stephen Henderson, Matthew John Hayes, Sara Sofia Marelli, Yifat Ofir-Birin, Neta Regev-Rudzki, Javier Herrero, Tariq Enver
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10.1371/journal.ppat.1006378

PLOS Pathogens Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques
May 25, 2017 Sydney M. Nguyen, Kathleen M. Antony, Dawn M. Dudley, Sarah Kohn, Heather A. Simmons, Bryce Wolfe, M. Shahriar Salamat, Leandro B. C. Teixeira, Gregory J. Wiepz, Troy H. Thoong, Matthew T. Aliota, Andrea M. Weiler, Gabrielle L. Barry, Kim L. Weisgrau, Logan J. Vosler, Mariel S. Mohns, Meghan E. Breitbach, Laurel M. Stewart, Mustafa N. Rasheed, Christina M. Newman, Michael E. Graham, Oliver E. Wieben, Patrick A. Turski, Kevin M. Johnson, Jennifer Post, Jennifer M. Hayes, Nancy Schultz-Darken, Michele L. Schotzko, Josh A. Eudailey, Sallie R. Permar, Eva G. Rakasz, Emma L. Mohr, Saverio Capuano III, Alice F. Tarantal, Jorge E. Osorio, Shelby L. O’Connor, Thomas C. Friedrich, David H. O’Connor, Thaddeus G. Golos
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10.1371/journal.ppat.1006159

PLOS Pathogens Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury
February 3, 2017 Martina Bielaszewska, Christian Rüter, Andreas Bauwens, Lilo Greune, Kevin-André Jarosch, Daniel Steil, Wenlan Zhang, Xiaohua He, Roland Lloubes, Angelika Fruth, Kwang Sik Kim, M. Alexander Schmidt, Ulrich Dobrindt, Alexander Mellmann, Helge Karch
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10.1371/journal.ppat.1006281

PLOS Pathogens Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry
April 12, 2017 Yiquan Wu, Adrian Prager, Simone Boos, Moritz Resch, Ilija Brizic, Michael Mach, Sabrina Wildner, Laura Scrivano, Barbara Adler
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10.1371/journal.ppat.1006487

PLOS Pathogens Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques
August 3, 2017 Michael K. McCracken, Gregory D. Gromowski, Heather L. Friberg, Xiaoxu Lin, Peter Abbink, Rafael De La Barrera, Kenneth H. Eckles, Lindsey S. Garver, Michael Boyd, David Jetton, Dan H. Barouch, Matthew C. Wise, Bridget S. Lewis, Jeffrey R. Currier, Kayvon Modjarrad, Mark Milazzo, Michelle Liu, Anna B. Mullins, J. Robert Putnak, Nelson L. Michael, Richard G. Jarman, Stephen J. Thomas
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10.1371/journal.ppat.1006502

PLOS Pathogens Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome
August 3, 2017 Danielle P. A. Mascarenhas, Daiane M. Cerqueira, Marcelo S. F. Pereira, Fernanda V. S. Castanheira, Talita D. Fernandes, Graziele Z. Manin, Larissa D. Cunha, Dario S. Zamboni
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10.1371/journal.ppat.1006285

PLOS Pathogens Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation
April 20, 2017 Rajesh T. Gandhi, Deborah K. McMahon, Ronald J. Bosch, Christina M. Lalama, Joshua C. Cyktor, Bernard J. Macatangay, Charles R. Rinaldo, Sharon A. Riddler, Evelyn Hogg, Catherine Godfrey, Ann C. Collier, Joseph J. Eron, John W. Mellors, ACTG A5321 Team
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10.1371/journal.ppat.1006576

PLOS Pathogens Malaria-induced interferon-γ drives the expansion of Tbet^hi atypical memory B cells
September 27, 2017 Nyamekye Obeng-Adjei, Silvia Portugal, Prasida Holla, Shanping Li, Haewon Sohn, Abhijit Ambegaonkar, Jeff Skinner, Georgina Bowyer, Ogobara K. Doumbo, Boubacar Traore, Susan K. Pierce, Peter D. Crompton
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10.1371/journal.ppat.1006513

PLOS Pathogens Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis
August 17, 2017 Koji Watanabe, Carol A. Gilchrist, Md Jashim Uddin, Stacey L. Burgess, Mayuresh M. Abhyankar, Shannon N. Moonah, Zannatun Noor, Jeffrey R. Donowitz, Brittany N. Schneider, Tuhinur Arju, Emtiaz Ahmed, Mamun Kabir, Masud Alam, Rashidul Haque, Patcharin Pramoonjago, Borna Mehrad, William A. Petri Jr.
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10.1371/journal.ppat.1006391

PLOS Pathogens Microbiota-induced peritrophic matrix regulates midgut homeostasis and prevents systemic infection of malaria vector mosquitoes
May 17, 2017 Faye H. Rodgers, Mathilde Gendrin, Claudia A. S. Wyer, George K. Christophides
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10.1371/journal.ppat.1006410

PLOS Pathogens MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection
May 30, 2017 Sanjaya Kumar Sahu, Manish Kumar, Sohini Chakraborty, Srijon Kaushik Banerjee, Ranjeet Kumar, Pushpa Gupta, Kuladip Jana, Umesh D. Gupta, Zhumur Ghosh, Manikuntala Kundu, Joyoti Basu
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10.1371/journal.ppat.1006137

PLOS Pathogens Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens
January 30, 2017 Robert Wilson, Jonathan M. Cohen, Mark Reglinski, Ricardo J. Jose, Win Yan Chan, Helina Marshall, Corné de Vogel, Stephen Gordon, David Goldblatt, Fernanda C. Petersen, Helen Baxendale, Jeremy S. Brown
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10.1371/journal.ppat.1006206

PLOS Pathogens Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function
February 23, 2017 Christine Burkard, Simon G. Lillico, Elizabeth Reid, Ben Jackson, Alan J. Mileham, Tahar Ait-Ali, C. Bruce A. Whitelaw, Alan L. Archibald
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10.1371/journal.ppat.1006108

PLOS Pathogens Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts
January 12, 2017 Thomas S. Churcher, Robert E. Sinden, Nick J. Edwards, Ian D. Poulton, Thomas W. Rampling, Patrick M. Brock, Jamie T. Griffin, Leanna M. Upton, Sara E. Zakutansky, Katarzyna A. Sala, Fiona Angrisano, Adrian V. S. Hill, Andrew M. Blagborough
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10.1371/journal.ppat.1006158

PLOS Pathogens Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector
January 23, 2017 Brian S. Mantilla, Letícia Marchese, Aitor Casas-Sánchez, Naomi A. Dyer, Nicholas Ejeh, Marc Biran, Frédéric Bringaud, Michael J. Lehane, Alvaro Acosta-Serrano, Ariel M. Silber
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10.1371/journal.ppat.1006283

PLOS Pathogens Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir
March 22, 2017 John K. Bui, Michele D. Sobolewski, Brandon F. Keele, Jonathan Spindler, Andrew Musick, Ann Wiegand, Brian T. Luke, Wei Shao, Stephen H. Hughes, John M. Coffin, Mary F. Kearney, John W. Mellors
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10.1371/journal.ppat.1006129

PLOS Pathogens Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis
January 5, 2017 Franziska Faber, Parameth Thiennimitr, Luisella Spiga, Mariana X. Byndloss, Yael Litvak, Sara Lawhon, Helene L. Andrews-Polymenis, Sebastian E. Winter, Andreas J. Bäumler
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10.1371/journal.ppat.1006687

PLOS Pathogens Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease
November 16, 2017 Thomas J. Scriba, Adam Penn-Nicholson, Smitha Shankar, Tom Hraha, Ethan G. Thompson, David Sterling, Elisa Nemes, Fatoumatta Darboe, Sara Suliman, Lynn M. Amon, Hassan Mahomed, Mzwandile Erasmus, Wendy Whatney, John L. Johnson, W. Henry Boom, Mark Hatherill, Joe Valvo, Mary Ann De Groote, Urs A. Ochsner, Alan Aderem, Willem A. Hanekom, Daniel E. Zak, other members of the ACS cohort study team
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10.1371/journal.ppat.1006000

PLOS Pathogens Social and Genetic Networks of HIV-1 Transmission in New York City
January 9, 2017 Joel O. Wertheim, Sergei L. Kosakovsky Pond, Lisa A. Forgione, Sanjay R. Mehta, Ben Murrell, Sharmila Shah, Davey M. Smith, Konrad Scheffler, Lucia V. Torian
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10.1371/journal.ppat.1006136

PLOS Pathogens Static and Evolving Norovirus Genotypes: Implications for Epidemiology and Immunity
January 19, 2017 Gabriel I. Parra, R. Burke Squires, Consolee K. Karangwa, Jordan A. Johnson, Cara J. Lepore, Stanislav V. Sosnovtsev, Kim Y. Green
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10.1371/journal.ppat.1006292

PLOS Pathogens The blood DNA virome in 8,000 humans
March 22, 2017 Ahmed Moustafa, Chao Xie, Ewen Kirkness, William Biggs, Emily Wong, Yaron Turpaz, Kenneth Bloom, Eric Delwart, Karen E. Nelson, J. Craig Venter, Amalio Telenti
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10.1371/journal.ppat.1006264

PLOS Pathogens The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response
March 8, 2017 Qiang Wang, Liyuan Huang, Ze Hong, Zhongshi Lv, Zhaomin Mao, Yijun Tang, Xiufang Kong, Senlin Li, Ye Cui, Heng Liu, Lele Zhang, Xiaojie Zhang, Lindi Jiang, Qin Zhou, Chen Wang
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10.1371/journal.ppat.1006504

PLOS Pathogens The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer
July 17, 2017 Sampriti Mukherjee, Dina Moustafa, Chari D. Smith, Joanna B. Goldberg, Bonnie L. Bassler
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10.1371/journal.ppat.1006390

PLOS Pathogens Three mutations switch H7N9 influenza to human-type receptor specificity
June 15, 2017 Robert P. de Vries, Wenjie Peng, Oliver C. Grant, Andrew J. Thompson, Xueyong Zhu, Kim M. Bouwman, Alba T. Torrents de la Pena, Marielle J. van Breemen, Iresha N. Ambepitiya Wickramasinghe, Cornelis A. M. de Haan, Wenli Yu, Ryan McBride, Rogier W. Sanders, Robert J. Woods, Monique H. Verheije, Ian A. Wilson, James C. Paulson
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10.1371/journal.ppat.1006145

PLOS Pathogens TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP)
January 6, 2017 Melody M. H. Li, Zerlina Lau, Pamela Cheung, Eduardo G. Aguilar, William M. Schneider, Leonia Bozzacco, Henrik Molina, Eugen Buehler, Akinori Takaoka, Charles M. Rice, Dan P. Felsenfeld, Margaret R. MacDonald
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10.1371/journal.ppat.1006164

PLOS Pathogens Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells
February 2, 2017 James R. Bowen, Kendra M. Quicke, Mohan S. Maddur, Justin T. O’Neal, Circe E. McDonald, Nadia B. Fedorova, Vinita Puri, Reed S. Shabman, Bali Pulendran, Mehul S. Suthar
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10.1371/journal.ppat.1006219

PLOS Pathogens Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues
March 9, 2017 Alec Hirsch, Jessica Smith, Nicole Haese, Rebecca Broeckel, Christopher Parkins, Craig Krecklywich, Victor DeFilippis, Michael Denton, Patricia Smith, William Messer, Lois Colgin, Rebecca Ducore, Peta Grigsby, Jon Hennebold, Tonya Swanson, Alfred Legasse, Michael Axthelm, Rhonda MacAllister, Clayton Wiley, Jay Nelson, Daniel Streblow
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10.1371/journal.ppat.1006537

PLOS Pathogens Zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques
July 26, 2017 Timothy Carroll, Ming Lo, Marion Lanteri, Joseph Dutra, Katie Zarbock, Paola Silveira, Tracy Rourke, Zhong-min Ma, Linda Fritts, Shelby O’Connor, Michael Busch, Christopher J. Miller

2016

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10.1371/journal.ppat.1005761

PLOS Pathogens CD4⁺ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART
July 14, 2016 Rémi Fromentin, Wendy Bakeman, Mariam B. Lawani, Gabriela Khoury, Wendy Hartogensis, Sandrina DaFonseca, Marisela Killian, Lorrie Epling, Rebecca Hoh, Elizabeth Sinclair, Frederick M. Hecht, Peter Bacchetti, Steven G. Deeks, Sharon R. Lewin, Rafick-Pierre Sékaly, Nicolas Chomont
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10.1371/journal.ppat.1005369

PLOS Pathogens Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort
January 14, 2016 Elise Landais, Xiayu Huang, Colin Havenar-Daughton, Ben Murrell, Matt A. Price, Lalinda Wickramasinghe, Alejandra Ramos, Charoan B. Bian, Melissa Simek, Susan Allen, Etienne Karita, William Kilembe, Shabir Lakhi, Mubiana Inambao, Anatoli Kamali, Eduard J. Sanders, Omu Anzala, Vinodh Edward, Linda-Gail Bekker, Jianming Tang, Jill Gilmour, Sergei L. Kosakovsky-Pond, Pham Phung, Terri Wrin, Shane Crotty, Adam Godzik, Pascal Poignard
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10.1371/journal.ppat.1005315

PLOS Pathogens Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control
January 8, 2016 Margaret E. Ackerman, Anastassia Mikhailova, Eric P. Brown, Karen G. Dowell, Bruce D. Walker, Chris Bailey-Kellogg, Todd J. Suscovich, Galit Alter
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10.1371/journal.ppat.1005667

PLOS Pathogens CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease
May 31, 2016 Shunsuke Sakai, Keith D. Kauffman, Michelle A. Sallin, Arlene H. Sharpe, Howard A. Young, Vitaly V. Ganusov, Daniel L. Barber
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10.1371/journal.ppat.1005763

PLOS Pathogens Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
July 28, 2016 Wesley C. Van Voorhis, John H. Adams, Roberto Adelfio, Vida Ahyong, Myles H. Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T. Andrews, Simon V. Avery, Vicky M. Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E. Boucher, Fabrice F. Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R. Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L. Colon, Daisy D. Colón-López, Yolanda Corbett, Gregory J. Crowther, Noemi Cowan, Sarah D’Alessandro, Na Le Dang, Michael Delves, Joseph L. DeRisi, Alan Y. Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T. Ferdig, José A. Fernández Robledo, David A. Fidock, Isabelle Florent, Patrick V. T. Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M. Goldgof, Rajarshi Guha, W. Armand Guiguemde, Nil Gural, R. Kiplin Guy, Michael A. E. Hansen, Kirsten K. Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B. Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A. Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T. Jensen, Rays H. Y. Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P. Kumar, Dennis E. Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M. Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I. Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R. Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N. Mfopa, Raj N. Misra, Seunghyun Moon, John P. Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K. Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M. Plouffe, Sally-Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J. Quinn, Christopher A. Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St. Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G. Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A. Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J. Sullivan, William Sullivan, Sundari Suresh, Brian M. Suzuki, Yo Suzuki, S. Joshua Swamidass, Donatella Taramelli, Lauve R. Y. Tchokouaha, Anjo Theron, David Thomas, Kathryn F. Tonissen, Simon Townson, Abhai K. Tripathi, Valentin Trofimov, Kenneth O. Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M. Vinetz, Phat Voong Vinh, Hoan Vu, Nao-aki Watanabe, Kate Weatherby, Pamela M. White, Andrew F. Wilks, Elizabeth A. Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H. A. Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A. Willis
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10.1371/journal.ppat.1005957

PLOS Pathogens Dissemination and Mechanism for the MCR-1 Colistin Resistance
November 28, 2016 Rongsui Gao, Yongfei Hu, Zhencui Li, Jian Sun, Qingjing Wang, Jingxia Lin, Huiyan Ye, Fei Liu, Swaminath Srinivas, Defeng Li, Baoli Zhu, Ya-Hong Liu, Guo-Bao Tian, Youjun Feng
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10.1371/journal.ppat.1005349

PLOS Pathogens TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection
January 7, 2016 Glen M. Chew, Tsuyoshi Fujita, Gabriela M. Webb, Benjamin J. Burwitz, Helen L. Wu, Jason S. Reed, Katherine B. Hammond, Kiera L. Clayton, Naoto Ishii, Mohamed Abdel-Mohsen, Teri Liegler, Brooks I. Mitchell, Frederick M. Hecht, Mario Ostrowski, Cecilia M. Shikuma, Scott G. Hansen, Mark Maurer, Alan J. Korman, Steven G. Deeks, Jonah B. Sacha, Lishomwa C. Ndhlovu
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10.1371/journal.ppat.1005901

PLOS Pathogens An RNAi-Based Control of Fusarium graminearum Infections Through Spraying of Long dsRNAs Involves a Plant Passage and Is Controlled by the Fungal Silencing Machinery
October 13, 2016 Aline Koch, Dagmar Biedenkopf, Alexandra Furch, Lennart Weber, Oliver Rossbach, Eltayb Abdellatef, Lukas Linicus, Jan Johannsmeier, Lukas Jelonek, Alexander Goesmann, Vinitha Cardoza, John McMillan, Tobias Mentzel, Karl-Heinz Kogel
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10.1371/journal.ppat.1005701

PLOS Pathogens CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections
June 30, 2016 Ferdy R. van Diemen, Elisabeth M. Kruse, Marjolein J. G. Hooykaas, Carlijn E. Bruggeling, Anita C. Schürch, Petra M. van Ham, Saskia M. Imhof, Monique Nijhuis, Emmanuel J. H. J. Wiertz, Robert Jan Lebbink
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10.1371/journal.ppat.1005672

PLOS Pathogens A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles
June 13, 2016 Katja Koeppen, Thomas H. Hampton, Michael Jarek, Maren Scharfe, Scott A. Gerber, Daniel W. Mielcarz, Elora G. Demers, Emily L. Dolben, John H. Hammond, Deborah A. Hogan, Bruce A. Stanton
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10.1371/journal.ppat.1005574

PLOS Pathogens The Ancient Evolutionary History of Polyomaviruses
April 19, 2016 Christopher B. Buck, Koenraad Van Doorslaer, Alberto Peretti, Eileen M. Geoghegan, Michael J. Tisza, Ping An, Joshua P. Katz, James M. Pipas, Alison A. McBride, Alvin C. Camus, Alexa J. McDermott, Jennifer A. Dill, Eric Delwart, Terry F. F. Ng, Kata Farkas, Charlotte Austin, Simona Kraberger, William Davison, Diana V. Pastrana, Arvind Varsani
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10.1371/journal.ppat.1005434

PLOS Pathogens Establishment of a Wolbachia Superinfection in Aedes aegypti Mosquitoes as a Potential Approach for Future Resistance Management
February 18, 2016 D. Albert Joubert, Thomas Walker, Lauren B. Carrington, Jyotika Taneja De Bruyne, Duong Hue T. Kien, Nhat Le Thanh Hoang, Nguyen Van Vinh Chau, Iñaki Iturbe-Ormaetxe, Cameron P. Simmons, Scott L. O’Neill
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10.1371/journal.ppat.1005578

PLOS Pathogens Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection
April 15, 2016 Gene S. Tan, Paul E. Leon, Randy A. Albrecht, Irina Margine, Ariana Hirsh, Justin Bahl, Florian Krammer
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10.1371/journal.ppat.1005408

PLOS Pathogens IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid
February 1, 2016 Jan Naujoks, Christoph Tabeling, Brian D. Dill, Christine Hoffmann, Andrew S. Brown, Mareike Kunze, Stefan Kempa, Andrea Peter, Hans-Joachim Mollenkopf, Anca Dorhoi, Olivia Kershaw, Achim D. Gruber, Leif E. Sander, Martin Witzenrath, Susanne Herold, Andreas Nerlich, Andreas C. Hocke, Ian van Driel, Norbert Suttorp, Sammy Bedoui, Hubert Hilbi, Matthias Trost, Bastian Opitz
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10.1371/journal.ppat.1005606

PLOS Pathogens Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics
April 29, 2016 Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, Melanie J. Shears, Anke Harupa, Christine S. Hopp, Ashley M. Vaughan, Timothy A. Springer, Robert L. Moritz, Stefan H. I. Kappe, Photini Sinnis
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10.1371/journal.ppat.1005738

PLOS Pathogens Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability
July 14, 2016 Henry Puerta-Guardo, Dustin R. Glasner, Eva Harris
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10.1371/journal.ppat.1006004

PLOS Pathogens Zika (PRVABC59) Infection Is Associated with T cell Infiltration and Neurodegeneration in CNS of Immunocompetent Neonatal C57Bl/6 Mice
November 17, 2016 Mohanraj Manangeeswaran, Derek D. C. Ireland, Daniela Verthelyi
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10.1371/journal.ppat.1005520

PLOS Pathogens Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection
March 30, 2016 Kshitij Wagh, Tanmoy Bhattacharya, Carolyn Williamson, Alex Robles, Madeleine Bayne, Jetta Garrity, Michael Rist, Cecilia Rademeyer, Hyejin Yoon, Alan Lapedes, Hongmei Gao, Kelli Greene, Mark K. Louder, Rui Kong, Salim Abdool Karim, Dennis R. Burton, Dan H. Barouch, Michel C. Nussenzweig, John R. Mascola, Lynn Morris, David C. Montefiori, Bette Korber, Michael S. Seaman
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10.1371/journal.ppat.1005545

PLOS Pathogens A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4⁺ T-Cells to Recognition by Cytotoxic T-Lymphocytes
April 15, 2016 R. Brad Jones, Stefanie Mueller, Rachel O’Connor, Katherine Rimpel, Derek D. Sloan, Dan Karel, Hing C. Wong, Emily K. Jeng, Allison S. Thomas, James B. Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J. Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P. Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A. Ostrowski, Darrell J. Irvine, Bruce D. Walker
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10.1371/journal.ppat.1005546

PLOS Pathogens cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells
April 8, 2016 Jennifer Paijo, Marius Döring, Julia Spanier, Elena Grabski, Mohammed Nooruzzaman, Tobias Schmidt, Gregor Witte, Martin Messerle, Veit Hornung, Volkhard Kaever, Ulrich Kalinke
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10.1371/journal.ppat.1005864

PLOS Pathogens Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C
September 14, 2016 P. J. Klasse, Celia C. LaBranche, Thomas J. Ketas, Gabriel Ozorowski, Albert Cupo, Pavel Pugach, Rajesh P. Ringe, Michael Golabek, Marit J. van Gils, Miklos Guttman, Kelly K. Lee, Ian A. Wilson, Salvatore T. Butera, Andrew B. Ward, David C. Montefiori, Rogier W. Sanders, John P. Moore
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10.1371/journal.ppat.1005809

PLOS Pathogens The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent
August 8, 2016 Kirsten E. Wiens, Joel D. Ernst
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10.1371/journal.ppat.1005835

PLOS Pathogens The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy
September 8, 2016 Ester Vázquez-Fernández, Matthijn R. Vos, Pavel Afanasyev, Lino Cebey, Alejandro M. Sevillano, Enric Vidal, Isaac Rosa, Ludovic Renault, Adriana Ramos, Peter J. Peters, José Jesús Fernández, Marin van Heel, Howard S. Young, Jesús R. Requena, Holger Wille
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10.1371/journal.ppat.1005817

PLOS Pathogens Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses
August 31, 2016 Matthew Zirui Tay, Pinghuang Liu, LaTonya D. Williams, Michael D McRaven, Sheetal Sawant, Thaddeus C Gurley, Thomas T. Xu, S. Moses Dennison, Hua-Xin Liao, Agnès-Laurence Chenine, S. Munir Alam, M. Anthony Moody, Thomas J. Hope, Barton F. Haynes, Georgia D. Tomaras
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10.1371/journal.ppat.1005735

PLOS Pathogens VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System
June 28, 2016 Francesca R. Cianfanelli, Juliana Alcoforado Diniz, Manman Guo, Virginia De Cesare, Matthias Trost, Sarah J. Coulthurst
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10.1371/journal.ppat.1005572

PLOS Pathogens Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons
May 5, 2016 Elisa Deriu, Gayle M. Boxx, Xuesong He, Calvin Pan, Sammy David Benavidez, Lujia Cen, Nora Rozengurt, Wenyuan Shi, Genhong Cheng
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10.1371/journal.ppat.1005744

PLOS Pathogens The Dermis as a Delivery Site of Trypanosoma brucei for Tsetse Flies
July 21, 2016 Guy Caljon, Nick Van Reet, Carl De Trez, Marjorie Vermeersch, David Pérez-Morga, Jan Van Den Abbeele
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10.1371/journal.ppat.1005511

PLOS Pathogens Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection
April 5, 2016 Yuan Li, Sheena Shah-Simpson, Kwame Okrah, A. Trey Belew, Jungmin Choi, Kacey L. Caradonna, Prasad Padmanabhan, David M. Ndegwa, M. Ramzi Temanni, Héctor Corrada Bravo, Najib M. El-Sayed, Barbara A. Burleigh
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10.1371/journal.ppat.1005846

PLOS Pathogens Evidence and Role for Bacterial Mucin Degradation in Cystic Fibrosis Airway Disease
August 22, 2016 Jeffrey M. Flynn, David Niccum, Jordan M. Dunitz, Ryan C. Hunter
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10.1371/journal.ppat.1005661

PLOS Pathogens Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection
July 14, 2016 Matthias Hoffmann, Nikos Pantazis, Genevieve E. Martin, Stephen Hickling, Jacob Hurst, Jodi Meyerowitz, Christian B. Willberg, Nicola Robinson, Helen Brown, Martin Fisher, Sabine Kinloch, Abdel Babiker, Jonathan Weber, Nneka Nwokolo, Julie Fox, Sarah Fidler, Rodney Phillips, SPARTAC and CHERUB Investigators , John Frater
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10.1371/journal.ppat.1005815

PLOS Pathogens Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design
August 25, 2016 Joseph G. Jardine, Devin Sok, Jean-Philippe Julien, Bryan Briney, Anita Sarkar, Chi-Hui Liang, Erin A. Scherer, Carole J. Henry Dunand, Yumiko Adachi, Devan Diwanji, Jessica Hsueh, Meaghan Jones, Oleksandr Kalyuzhniy, Michael Kubitz, Skye Spencer, Matthias Pauthner, Karen L. Saye-Francisco, Fabian Sesterhenn, Patrick C. Wilson, Denise M. Galloway, Robyn L. Stanfield, Ian A. Wilson, Dennis R. Burton, William R. Schief
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10.1371/journal.ppat.1005687

PLOS Pathogens Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment
June 15, 2016 Simone A. Joosten, Krista E. van Meijgaarden, Franca del Nonno, Andrea Baiocchini, Linda Petrone, Valentina Vanini, Hermelijn H. Smits, Fabrizio Palmieri, Delia Goletti, Tom H. M. Ottenhoff
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10.1371/journal.ppat.1005490

PLOS Pathogens TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection
March 11, 2016 Pushpa Jayaraman, Miye K. Jacques, Chen Zhu, Katherine M. Steblenko, Britni L. Stowell, Asaf Madi, Ana C. Anderson, Vijay K. Kuchroo, Samuel M. Behar
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10.1371/journal.ppat.1005619

PLOS Pathogens Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus
May 10, 2016 Damien C. Tully, Colin B. Ogilvie, Rebecca E. Batorsky, David J. Bean, Karen A. Power, Musie Ghebremichael, Hunter E. Bedard, Adrianne D. Gladden, Aaron M. Seese, Molly A. Amero, Kimberly Lane, Graham McGrath, Suzane B. Bazner, Jake Tinsley, Niall J. Lennon, Matthew R. Henn, Zabrina L. Brumme, Philip J. Norris, Eric S. Rosenberg, Kenneth H. Mayer, Heiko Jessen, Sergei L. Kosakovsky Pond, Bruce D. Walker, Marcus Altfeld, Jonathan M. Carlson, Todd M. Allen
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10.1371/journal.ppat.1005447

PLOS Pathogens Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii
February 19, 2016 Carla M. Cabral, Shraddha Tuladhar, Hans K. Dietrich, Elizabeth Nguyen, Wes R. MacDonald, Tapasya Trivedi, Asha Devineni, Anita A. Koshy
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10.1371/journal.ppat.1005361

PLOS Pathogens A Shift from Cellular to Humoral Responses Contributes to Innate Immune Memory in the Vector Snail Biomphalaria glabrata
January 6, 2016 Silvain Pinaud, Julien Portela, David Duval, Fanny C. Nowacki, Marie-Aude Olive, Jean-François Allienne, Richard Galinier, Nolwenn M. Dheilly, Sylvie Kieffer-Jaquinod, Guillaume Mitta, André Théron, Benjamin Gourbal
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10.1371/journal.ppat.1005841

PLOS Pathogens The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing
August 30, 2016 Federico A. De Maio, Guillermo Risso, Nestor G. Iglesias, Priya Shah, Berta Pozzi, Leopoldo G. Gebhard, Pablo Mammi, Estefania Mancini, Marcelo J. Yanovsky, Raul Andino, Nevan Krogan, Anabella Srebrow, Andrea V. Gamarnik
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10.1371/journal.ppat.1005457

PLOS Pathogens Cytokinin Production by the Rice Blast Fungus Is a Pivotal Requirement for Full Virulence
February 22, 2016 Emilie Chanclud, Anna Kisiala, Neil R. J Emery, Véronique Chalvon, Aurélie Ducasse, Corinne Romiti-Michel, Antoine Gravot, Thomas Kroj, Jean-Benoit Morel
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10.1371/journal.ppat.1005644

PLOS Pathogens Neutrophil Attack Triggers Extracellular Trap-Dependent Candida Cell Wall Remodeling and Altered Immune Recognition
May 25, 2016 Alex Hopke, Nadine Nicke, Erica E. Hidu, Genny Degani, Laura Popolo, Robert T. Wheeler
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10.1371/journal.ppat.1006022

PLOS Pathogens CD8⁺ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature
December 1, 2016 Phillip A. Swanson II, Geoffrey T. Hart, Matthew V. Russo, Debasis Nayak, Takele Yazew, Mirna Peña, Shahid M. Khan, Chris J. Janse, Susan K. Pierce, Dorian B. McGavern
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10.1371/journal.ppat.1005832

PLOS Pathogens Cytomegalovirus Infection Leads to Development of High Frequencies of Cytotoxic Virus-Specific CD4+ T Cells Targeted to Vascular Endothelium
September 8, 2016 Annette Pachnio, Miriam Ciaurriz, Jusnara Begum, Neeraj Lal, Jianmin Zuo, Andrew Beggs, Paul Moss
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10.1371/journal.ppat.1005418

PLOS Pathogens Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike
February 5, 2016 Sai Li, Zhaoyang Sun, Rhys Pryce, Marie-Laure Parsy, Sarah K. Fehling, Katrin Schlie, C. Alistair Siebert, Wolfgang Garten, Thomas A. Bowden, Thomas Strecker, Juha T. Huiskonen
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10.1371/journal.ppat.1005472

PLOS Pathogens Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth
March 3, 2016 Maja Kiselinova, Ward De Spiegelaere, Maria Jose Buzon, Eva Malatinkova, Mathias Lichterfeld, Linos Vandekerckhove
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10.1371/journal.ppat.1005428

PLOS Pathogens The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites
February 10, 2016 Christopher J. Neufeldt, Michael A. Joyce, Nicholas Van Buuren, Aviad Levin, Karla Kirkegaard, Michael Gale Jr., D. Lorne J. Tyrrell, Richard W. Wozniak
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10.1371/journal.ppat.1005611

PLOS Pathogens Antibiotic-Resistant Neisseria gonorrhoeae Spread Faster with More Treatment, Not More Sexual Partners
May 19, 2016 Stephanie M. Fingerhuth, Sebastian Bonhoeffer, Nicola Low, Christian L. Althaus
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10.1371/journal.ppat.1005456

PLOS Pathogens Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination
March 16, 2016 Alison E. Mahan, Madeleine F. Jennewein, Todd Suscovich, Kendall Dionne, Jacquelynne Tedesco, Amy W. Chung, Hendrik Streeck, Maria Pau, Hanneke Schuitemaker, Don Francis, Patricia Fast, Dagna Laufer, Bruce D. Walker, Lindsey Baden, Dan H. Barouch, Galit Alter
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10.1371/journal.ppat.1005810

PLOS Pathogens New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes
August 10, 2016 Dal Young Kim, Josephine M. Reynaud, Aliaksandra Rasalouskaya, Ivan Akhrymuk, James A. Mobley, Ilya Frolov, Elena I. Frolova
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10.1371/journal.ppat.1005737

PLOS Pathogens Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
August 8, 2016 Siew Pheng Lim, Christian Guy Noble, Cheah Chen Seh, Tingjin Sherryl Soh, Abbas El Sahili, Grace Kar Yarn Chan, Julien Lescar, Rishi Arora, Timothy Benson, Shahul Nilar, Ujjini Manjunatha, Kah Fei Wan, Hongping Dong, Xuping Xie, Pei-Yong Shi, Fumiaki Yokokawa
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10.1371/journal.ppat.1005702

PLOS Pathogens Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody
June 28, 2016 Ning Chai, Lee R. Swem, Mike Reichelt, Haiyin Chen-Harris, Elizabeth Luis, Summer Park, Ashley Fouts, Patrick Lupardus, Thomas D. Wu, Olga Li, Jacqueline McBride, Michael Lawrence, Min Xu, Man-Wah Tan
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10.1371/journal.ppat.1005368

PLOS Pathogens TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity
January 14, 2016 Alicja Puchta, Avee Naidoo, Chris P. Verschoor, Dessi Loukov, Netusha Thevaranjan, Talveer S. Mandur, Phuong-son Nguyen, Manel Jordana, Mark Loeb, Zhou Xing, Lester Kobzik, Maggie J. Larché, Dawn M. E. Bowdish
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10.1371/journal.ppat.1005939

PLOS Pathogens A Resource Allocation Trade-Off between Virulence and Proliferation Drives Metabolic Versatility in the Plant Pathogen Ralstonia solanacearum
October 12, 2016 Rémi Peyraud, Ludovic Cottret, Lucas Marmiesse, Jérôme Gouzy, Stéphane Genin
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10.1371/journal.ppat.1005427

PLOS Pathogens Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein
February 5, 2016 Denys A. Khaperskyy, Summer Schmaling, Jonah Larkins-Ford, Craig McCormick, Marta M. Gaglia
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10.1371/journal.ppat.1005811

PLOS Pathogens The Arabidopsis Protein Phosphatase PP2C38 Negatively Regulates the Central Immune Kinase BIK1
August 5, 2016 Daniel Couto, Roda Niebergall, Xiangxiu Liang, Christoph A. Bücherl, Jan Sklenar, Alberto P. Macho, Vardis Ntoukakis, Paul Derbyshire, Denise Altenbach, Dan Maclean, Silke Robatzek, Joachim Uhrig, Frank Menke, Jian-Min Zhou, Cyril Zipfel
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10.1371/journal.ppat.1005884

PLOS Pathogens The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps
September 13, 2016 Chad J. Johnson, Jonathan Cabezas-Olcoz, John F. Kernien, Steven X. Wang, David J. Beebe, Anna Huttenlocher, Hamayail Ansari, Jeniel E. Nett

2015

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10.1371/journal.ppat.1005142

PLOS Pathogens The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo
September 17, 2015 Ole S. Søgaard, Mette E. Graversen, Steffen Leth, Rikke Olesen, Christel R. Brinkmann, Sara K. Nissen, Anne Sofie Kjaer, Mariane H. Schleimann, Paul W. Denton, William J. Hey-Cunningham, Kersten K. Koelsch, Giuseppe Pantaleo, Kim Krogsgaard, Maja Sommerfelt, Remi Fromentin, Nicolas Chomont, Thomas A. Rasmussen, Lars Østergaard, Martin Tolstrup
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10.1371/journal.ppat.1004603

PLOS Pathogens Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization
January 22, 2015 Hannah Priyadarshini Gideon, JiaYao Phuah, Amy J. Myers, Bryan D. Bryson, Mark A. Rodgers, M. Teresa Coleman, Pauline Maiello, Tara Rutledge, Simeone Marino, Sarah M. Fortune, Denise E. Kirschner, Philana Ling Lin, JoAnne L. Flynn
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10.1371/journal.ppat.1004670

PLOS Pathogens Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes
February 27, 2015 Greta Weiss, Paul Gilson, Tana Taechalertpaisarn, Wai-Hong Tham, Nienke de Jong, Katherine Harvey, Freya Fowkes, Paul Barlow, Julian Rayner, Gavin Wright, Alan Cowman, Brendan Crabb
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10.1371/journal.ppat.1004679

PLOS Pathogens Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment
February 12, 2015 Brian C. VanderVen, Ruth J. Fahey, Wonsik Lee, Yancheng Liu, Robert B. Abramovitch, Christine Memmott, Adam M. Crowe, Lindsay D. Eltis, Emanuele Perola, David D. Deininger, Tiansheng Wang, Christopher P. Locher, David G. Russell
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10.1371/journal.ppat.1004820

PLOS Pathogens Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage
April 16, 2015 Kipyegon Kitur, Dane Parker, Pamela Nieto, Danielle S. Ahn, Taylor S. Cohen, Samuel Chung, Sarah Wachtel, Susan Bueno, Alice Prince
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10.1371/journal.ppat.1004955

PLOS Pathogens HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells
June 11, 2015 Leonard Chavez, Vincenzo Calvanese, Eric Verdin
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10.1371/journal.ppat.1004691

PLOS Pathogens Antibiotic Modulation of Capsular Exopolysaccharide and Virulence in Acinetobacter baumannii
February 13, 2015 Edward Geisinger, Ralph R. Isberg
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10.1371/journal.ppat.1004650

PLOS Pathogens Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo
February 6, 2015 Roxane Simeone, Fadel Sayes, Okryul Song, Matthias I. Gröschel, Priscille Brodin, Laleh Majlessi, Roland Brosch
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10.1371/journal.ppat.1005066

PLOS Pathogens Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation
July 30, 2015 Guochun Jiang, Erica A. Mendes, Philipp Kaiser, Daniel P. Wong, Yuyang Tang, Ivy Cai, Anne Fenton, Gregory P. Melcher, James E. K. Hildreth, George R. Thompson, Joseph K. Wong, Satya Dandekar
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10.1371/journal.ppat.1004892

PLOS Pathogens The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii
May 15, 2015 Olivier Duron, Valérie Noël, Karen D. McCoy, Matteo Bonazzi, Karim Sidi-Boumedine, Olivier Morel, Fabrice Vavre, Lionel Zenner, Elsa Jourdain, Patrick Durand, Céline Arnathau, François Renaud, Jean-François Trape, Abel S. Biguezoton, Julie Cremaschi, Muriel Dietrich, Elsa Léger, Anaïs Appelgren, Marlène Dupraz, Elena Gómez-Díaz, Georges Diatta, Guiguigbaza-Kossigan Dayo, Hassane Adakal, Sébastien Zoungrana, Laurence Vial, Christine Chevillon
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10.1371/journal.ppat.1005262

PLOS Pathogens RNA-seq Brings New Insights to the Intra-Macrophage Transcriptome of Salmonella Typhimurium
November 12, 2015 Shabarinath Srikumar, Carsten Kröger, Magali Hébrard, Aoife Colgan, Siân V. Owen, Sathesh K. Sivasankaran, Andrew D. S. Cameron, Karsten Hokamp, Jay C. D. Hinton
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10.1371/journal.ppat.1004932

PLOS Pathogens Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site
May 29, 2015 Ema T. Crooks, Tommy Tong, Bimal Chakrabarti, Kristin Narayan, Ivelin S. Georgiev, Sergey Menis, Xiaoxing Huang, Daniel Kulp, Keiko Osawa, Janelle Muranaka, Guillaume Stewart-Jones, Joanne Destefano, Sijy O’Dell, Celia LaBranche, James E. Robinson, David C. Montefiori, Krisha McKee, Sean X. Du, Nicole Doria-Rose, Peter D. Kwong, John R. Mascola, Ping Zhu, William R. Schief, Richard T. Wyatt, Robert G. Whalen, James M. Binley
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10.1371/journal.ppat.1005153

PLOS Pathogens Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection
September 24, 2015 Abderaouf Damouche, Thierry Lazure, Véronique Avettand-Fènoël, Nicolas Huot, Nathalie Dejucq-Rainsford, Anne-Pascale Satie, Adeline Mélard, Ludivine David, Céline Gommet, Jade Ghosn, Nicolas Noel, Guillaume Pourcher, Valérie Martinez, Stéphane Benoist, Véronique Béréziat, Antonio Cosma, Benoit Favier, Bruno Vaslin, Christine Rouzioux, Jacqueline Capeau, Michaela Müller-Trutwin, Nathalie Dereuddre-Bosquet, Roger Le Grand, Olivier Lambotte, Christine Bourgeois
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10.1371/journal.ppat.1004782

PLOS Pathogens Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections
April 7, 2015 Tanel Mahlakõiv, Pedro Hernandez, Konrad Gronke, Andreas Diefenbach, Peter Staeheli
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10.1371/journal.ppat.1005072

PLOS Pathogens Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection
August 21, 2015 Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F. Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K. Sandberg
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10.1371/journal.ppat.1004593

PLOS Pathogens DNA Is an Antimicrobial Component of Neutrophil Extracellular Traps
January 15, 2015 Tyler W.R. Halverson, Mike Wilton, Karen K. H. Poon, Björn Petri, Shawn Lewenza
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10.1371/journal.ppat.1004682

PLOS Pathogens A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication
March 16, 2015 Yongqian Zhao, Tingjin Sherryl Soh, Jie Zheng, Kitti Wing Ki Chan, Wint Wint Phoo, Chin Chin Lee, Moon Y. F. Tay, Kunchithapadam Swaminathan, Tobias C. Cornvik, Siew Pheng Lim, Pei-Yong Shi, Julien Lescar, Subhash G. Vasudevan, Dahai Luo
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10.1371/journal.ppat.1004701

PLOS Pathogens Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection
March 12, 2015 Darin L. Wiesner, Charles A. Specht, Chrono K. Lee, Kyle D. Smith, Liliane Mukaremera, S. Thera Lee, Chun G. Lee, Jack A. Elias, Judith N. Nielsen, David R. Boulware, Paul R. Bohjanen, Marc K. Jenkins, Stuart M. Levitz, Kirsten Nielsen
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10.1371/journal.ppat.1005042

PLOS Pathogens Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques
August 3, 2015 Sampa Santra, Georgia D. Tomaras, Ranjit Warrier, Nathan I. Nicely, Hua-Xin Liao, Justin Pollara, Pinghuang Liu, S. Munir Alam, Ruijun Zhang, Sarah L. Cocklin, Xiaoying Shen, Ryan Duffy, Shi-Mao Xia, Robert J. Schutte, Charles W. Pemble IV, S. Moses Dennison, Hui Li, Andrew Chao, Kora Vidnovic, Abbey Evans, Katja Klein, Amit Kumar, James Robinson, Gary Landucci, Donald N. Forthal, David C. Montefiori, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Merlin L. Robb, Nelson L. Michael, Jerome H. Kim, Kelly A. Soderberg, Elena E. Giorgi, Lily Blair, Bette T. Korber, Christiane Moog, Robin J. Shattock, Norman L. Letvin, Joern E. Schmitz, M. A. Moody, Feng Gao, Guido Ferrari, George M. Shaw, Barton F. Haynes
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10.1371/journal.ppat.1004712

PLOS Pathogens Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells
March 11, 2015 Anja Honegger, Daniela Schilling, Sandra Bastian, Jasmin Sponagel, Vladimir Kuryshev, Holger Sültmann, Martin Scheffner, Karin Hoppe-Seyler, Felix Hoppe-Seyler
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10.1371/journal.ppat.1005337

PLOS Pathogens Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia
December 11, 2015 Norberto González-Juarbe, Ryan Paul Gilley, Cecilia Anahí Hinojosa, Kelley Margaret Bradley, Akinobu Kamei, Geli Gao, Peter Herman Dube, Molly Ann Bergman, Carlos Javier Orihuela
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10.1371/journal.ppat.1005318

PLOS Pathogens Respiratory Syncytial Virus Uses CX3CR1 as a Receptor on Primary Human Airway Epithelial Cultures
December 11, 2015 Sara M. Johnson, Beth A. McNally, Ioannis Ioannidis, Emilio Flano, Michael N. Teng, Antonius G. Oomens, Edward E. Walsh, Mark E. Peeples
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10.1371/journal.ppat.1004720

PLOS Pathogens Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection
March 26, 2015 Christa Buckheit Sturdevant, Sarah B. Joseph, Gretja Schnell, Richard W. Price, Ronald Swanstrom, Serena Spudich
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10.1371/journal.ppat.1005015

PLOS Pathogens Transfer of Immunity from Mother to Offspring Is Mediated via Egg-Yolk Protein Vitellogenin
July 31, 2015 Heli Salmela, Gro V. Amdam, Dalial Freitak
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10.1371/journal.ppat.1004664

PLOS Pathogens Evolution of Genome Size and Complexity in the Rhabdoviridae
February 13, 2015 Peter J. Walker, Cadhla Firth, Steven G. Widen, Kim R. Blasdell, Hilda Guzman, Thomas G. Wood, Prasad N. Paradkar, Edward C. Holmes, Robert B. Tesh, Nikos Vasilakis
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10.1371/journal.ppat.1005277

PLOS Pathogens Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins
November 12, 2015 Pietro Scaturro, Mirko Cortese, Laurent Chatel-Chaix, Wolfgang Fischl, Ralf Bartenschlager
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10.1371/journal.ppat.1004604

PLOS Pathogens Dengue Virus RNA Structure Specialization Facilitates Host Adaptation
January 30, 2015 Sergio Villordo, Claudia Filomatori, Irma Sánchez-Vargas, Carol Blair, Andrea Gamarnik
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10.1371/journal.ppat.1005174

PLOS Pathogens The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy
October 9, 2015 David A. Tumbarello, Paul T. Manna, Mark Allen, Mark Bycroft, Susan D. Arden, John Kendrick-Jones, Folma Buss
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10.1371/journal.ppat.1005293

PLOS Pathogens CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System
December 17, 2015 Rebecca A. Drummond, Amanda L. Collar, Muthulekha Swamydas, Carlos A. Rodriguez, Jean K. Lim, Laura M. Mendez, Danielle L. Fink, Amy P. Hsu, Bing Zhai, Hatice Karauzum, Constantinos M. Mikelis, Stacey R. Rose, Elise M. N. Ferre, Lynne Yockey, Kimberly Lemberg, Hye Sun Kuehn, Sergio D. Rosenzweig, Xin Lin, Prashant Chittiboina, Sandip K. Datta, Thomas H. Belhorn, Eric T. Weimer, Michelle L. Hernandez, Tobias M. Hohl, Douglas B. Kuhns, Michail S. Lionakis
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10.1371/journal.ppat.1005177

PLOS Pathogens CD39 Expression Identifies Terminally Exhausted CD8⁺ T Cells
October 20, 2015 Prakash K. Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E. Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G. Junger, Simon C. Robson, E. John Wherry, Galit Alter, Philip J. R. Goulder, Paul Klenerman, Arlene H. Sharpe, Georg M. Lauer, W. Nicholas Haining
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10.1371/journal.ppat.1004663

PLOS Pathogens CD44 Plays a Functional Role in Helicobacter pylori-induced Epithelial Cell Proliferation
February 6, 2015 Nina Bertaux-Skeirik, Rui Feng, Michael A. Schumacher, Jing Li, Maxime M. Mahe, Amy C. Engevik, Jose E. Javier, Richard M. Peek Jr, Karen Ottemann, Veronique Orian-Rousseau, Gregory P. Boivin, Michael A. Helmrath, Yana Zavros
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10.1371/journal.ppat.1005035

PLOS Pathogens Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein
July 10, 2015 Morgan S. A. Gilman, Syed M. Moin, Vicente Mas, Man Chen, Nita K. Patel, Kari Kramer, Qing Zhu, Stephanie C. Kabeche, Azad Kumar, Concepción Palomo, Tim Beaumont, Ulrich Baxa, Nancy D. Ulbrandt, José A. Melero, Barney S. Graham, Jason S. McLellan
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10.1371/journal.ppat.1004767

PLOS Pathogens Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer
March 25, 2015 Ronald Derking, Gabriel Ozorowski, Kwinten Sliepen, Anila Yasmeen, Albert Cupo, Jonathan L. Torres, Jean-Philippe Julien, Jeong Hyun Lee, Thijs van Montfort, Steven W. de Taeye, Mark Connors, Dennis R. Burton, Ian A. Wilson, Per-Johan Klasse, Andrew B. Ward, John P. Moore, Rogier W. Sanders
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10.1371/journal.ppat.1004625

PLOS Pathogens IL-1α Signaling Is Critical for Leukocyte Recruitment after Pulmonary Aspergillus fumigatus Challenge
January 28, 2015 Alayna K. Caffrey, Margaret M. Lehmann, Julianne M. Zickovich, Vanessa Espinosa, Kelly M. Shepardson, Christopher P. Watschke, Kimberly M. Hilmer, Arsa Thammahong, Bridget M. Barker, Amariliz Rivera, Robert A. Cramer, Joshua J. Obar
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10.1371/journal.ppat.1005217

PLOS Pathogens Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33
October 16, 2015 Jordy Saravia, Dahui You, Bishwas Shrestha, Sridhar Jaligama, David Siefker, Greg I. Lee, Jeffrey N. Harding, Tamekia L. Jones, Cynthia Rovnaghi, Bindiya Bagga, John P. DeVincenzo, Stephania A. Cormier
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10.1371/journal.ppat.1004643

PLOS Pathogens Recognition of Aspergillus fumigatus Hyphae by Human Plasmacytoid Dendritic Cells Is Mediated by Dectin-2 and Results in Formation of Extracellular Traps
February 6, 2015 Flávio V. Loures, Marc Röhm, Chrono K. Lee, Evelyn Santos, Jennifer P. Wang, Charles A. Specht, Vera L. G. Calich, Constantin F. Urban, Stuart M. Levitz
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10.1371/journal.ppat.1004755

PLOS Pathogens Roles and Programming of Arabidopsis ARGONAUTE Proteins during Turnip Mosaic Virus Infection
March 25, 2015 Hernan Garcia-Ruiz, Alberto Carbonell, J. Steen Hoyer, Noah Fahlgren, Kerrigan B. Gilbert, Atsushi Takeda, Annalisa Giampetruzzi, Mayra T. Garcia Ruiz, Michaela G. McGinn, Nicholas Lowery, Maria T. Martinez Baladejo, James C. Carrington
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10.1371/journal.ppat.1004870

PLOS Pathogens Sigma Factor SigB Is Crucial to Mediate Staphylococcus aureus Adaptation during Chronic Infections
April 29, 2015 Lorena Tuchscherr, Markus Bischoff, Santiago M. Lattar, Mariangeles Noto Llana, Henrike Pförtner, Silke Niemann, Jennifer Geraci, Hélène Van de Vyver, Martin J. Fraunholz, Ambrose L. Cheung, Mathias Herrmann, Uwe Völker, Daniel O. Sordelli, Georg Peters, Bettina Löffler
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10.1371/journal.ppat.1004754

PLOS Pathogens Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis
April 8, 2015 Joseph N. Jarvis, Graeme Meintjes, Tihana Bicanic, Viviana Buffa, Louise Hogan, Stephanie Mo, Gillian Tomlinson, Pascale Kropf, Mahdad Noursadeghi, Thomas S. Harrison
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10.1371/journal.ppat.1004838

PLOS Pathogens Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype
May 5, 2015 Antonio V. Bordería, Ofer Isakov, Gonzalo Moratorio, Rasmus Henningsson, Sonia Agüera-González, Lindsey Organtini, Nina F. Gnädig, Hervé Blanc, Andrés Alcover, Susan Hafenstein, Magnus Fontes, Noam Shomron, Marco Vignuzzi
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10.1371/journal.ppat.1005226

PLOS Pathogens Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection
November 5, 2015 Aisling F. Brown, Alison G. Murphy, Stephen J. Lalor, John M. Leech, Kate M. O’Keeffe, Micheál Mac Aogáin, Dara P. O’Halloran, Keenan A. Lacey, Mehri Tavakol, Claire H. Hearnden, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Jérôme P. Fennell, Willem J. van Wamel, Timothy J. Foster, Joan A. Geoghegan, Ed C. Lavelle, Thomas R. Rogers, Rachel M. McLoughlin
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10.1371/journal.ppat.1005012

PLOS Pathogens TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING
June 26, 2015 Yanming Wang, Qiaoshi Lian, Bo Yang, Shanshan Yan, Haiyan Zhou, Lan He, Guomei Lin, Zhexiong Lian, Zhengfan Jiang, Bing Sun
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10.1371/journal.ppat.1004570

PLOS Pathogens Well-Ordered Trimeric HIV-1 Subtype B and C Soluble Spike Mimetics Generated by Negative Selection Display Native-like Properties
January 8, 2015 Javier Guenaga, Natalia de Val, Karen Tran, Yu Feng, Karen Satchwell, Andrew B. Ward, Richard T. Wyatt
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10.1371/journal.ppat.1004917

PLOS Pathogens Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
May 21, 2015 Catherine W. M. Ong, Paul T. Elkington, Sara Brilha, Cesar Ugarte-Gil, Maite T. Tome-Esteban, Liku B. Tezera, Przemyslaw J. Pabisiak, Rachel C. Moores, Tarangini Sathyamoorthy, Vimal Patel, Robert H. Gilman, Joanna C. Porter, Jon S. Friedland
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10.1371/journal.ppat.1004884

PLOS Pathogens Paradoxical Immune Responses in Non-HIV Cryptococcal Meningitis
May 28, 2015 Anil A. Panackal, Simone C. Wuest, Yen-Chih Lin, Tianxia Wu, Nannan Zhang, Peter Kosa, Mika Komori, Andrew Blake, Sarah K. Browne, Lindsey B. Rosen, Ferry Hagen, Jacques Meis, Stuart M. Levitz, Martha Quezado, Dima Hammoud, John E. Bennett, Bibi Bielekova, Peter R. Williamson
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10.1371/journal.ppat.1004983

PLOS Pathogens Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains
June 18, 2015 Christina D. Orrú, Bradley R. Groveman, Lynne D. Raymond, Andrew G. Hughson, Romolo Nonno, Wenquan Zou, Bernardino Ghetti, Pierluigi Gambetti, Byron Caughey
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10.1371/journal.ppat.1004558

PLOS Pathogens Parasite Biomass-Related Inflammation, Endothelial Activation, Microvascular Dysfunction and Disease Severity in Vivax Malaria
January 8, 2015 Bridget Barber, Timothy William, Matthew Grigg, Uma Parameswaran, Kim Piera, Ric Price, Tsin Yeo, Nicholas Anstey
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10.1371/journal.ppat.1005020

PLOS Pathogens Type VI Secretion System Transports Zn²⁺ to Combat Multiple Stresses and Host Immunity
July 2, 2015 Tietao Wang, Meiru Si, Yunhong Song, Wenhan Zhu, Fen Gao, Yao Wang, Lei Zhang, Weipeng Zhang, Gehong Wei, Zhao-Qing Luo, Xihui Shen
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10.1371/journal.ppat.1004637

PLOS Pathogens Lymph-Node Resident CD8α⁺ Dendritic Cells Capture Antigens from Migratory Malaria Sporozoites and Induce CD8⁺ T Cell Responses
February 6, 2015 Andrea Radtke, Wolfgang Kastenmüller, Diego Espinosa, Michael Gerner, Sze-Wah Tse, Photini Sinnis, Ronald Germain, Fidel Zavala, Ian Cockburn
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10.1371/journal.ppat.1004607

PLOS Pathogens IL-33-Mediated Protection against Experimental Cerebral Malaria Is Linked to Induction of Type 2 Innate Lymphoid Cells, M2 Macrophages and Regulatory T Cells
February 6, 2015 Anne-Gaelle Besnard, Rodrigo Guabiraba, Wanda Niedbala, Jennifer Palomo, Flora Reverchon, Tovah Shaw, Kevin Couper, Bernhard Ryffel, Foo Liew
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10.1371/journal.ppat.1004683

PLOS Pathogens Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling
February 25, 2015 Joachim Kloehn, Eleanor C. Saunders, Sean O’Callaghan, Michael J. Dagley, Malcolm J. McConville
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10.1371/journal.ppat.1005187

PLOS Pathogens The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps
October 22, 2015 Mark J. Lee, Hong Liu, Bridget M. Barker, Brendan D. Snarr, Fabrice N. Gravelat, Qusai Al Abdallah, Christina Gavino, Shane R. Baistrocchi, Hanna Ostapska, Tianli Xiao, Benjamin Ralph, Norma V. Solis, Mélanie Lehoux, Stefanie D. Baptista, Arsa Thammahong, Robert P. Cerone, Susan G. W. Kaminskyj, Marie-Christine Guiot, Jean-Paul Latgé, Thierry Fontaine, Donald C. Vinh, Scott G. Filler, Donald C. Sheppard
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10.1371/journal.ppat.1005185

PLOS Pathogens Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus
September 25, 2015 Cristina M. Dorobantu, Lucian Albulescu, Christian Harak, Qian Feng, Mirjam van Kampen, Jeroen R. P. M. Strating, Alexander E. Gorbalenya, Volker Lohmann, Hilde M. van der Schaar, Frank J. M. van Kuppeveld
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10.1371/journal.ppat.1005194

PLOS Pathogens Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction
October 2, 2015 Laurence H. Arnold, Harriet C. T. Groom, Simone Kunzelmann, David Schwefel, Sarah J. Caswell, Paula Ordonez, Melanie C. Mann, Sabrina Rueschenbaum, David C. Goldstone, Simon Pennell, Steven A. Howell, Jonathan P. Stoye, Michelle Webb, Ian A. Taylor, Kate N. Bishop
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10.1371/journal.ppat.1004689

PLOS Pathogens Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose
March 16, 2015 Darren J. Creek, Muriel Mazet, Fiona Achcar, Jana Anderson, Dong-Hyun Kim, Ruwida Kamour, Pauline Morand, Yoann Millerioux, Marc Biran, Eduard J. Kerkhoven, Achuthanunni Chokkathukalam, Stefan K. Weidt, Karl E. V. Burgess, Rainer Breitling, David G. Watson, Frédéric Bringaud, Michael P. Barrett
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10.1371/journal.ppat.1004699

PLOS Pathogens Direct Binding of Retromer to Human Papillomavirus Type 16 Minor Capsid Protein L2 Mediates Endosome Exit during Viral Infection
February 18, 2015 Andreea Popa, Wei Zhang, Megan S. Harrison, Kylia Goodner, Teymur Kazakov, Edward C. Goodwin, Alex Lipovsky, Christopher G. Burd, Daniel DiMaio
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10.1371/journal.ppat.1005246

PLOS Pathogens Host and Symbiont Jointly Control Gut Microbiota during Complete Metamorphosis
November 6, 2015 Paul R. Johnston, Jens Rolff
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10.1371/journal.ppat.1004672

PLOS Pathogens The Intracellular Bacterium Wolbachia Uses Parasitoid Wasps as Phoretic Vectors for Efficient Horizontal Transmission
February 12, 2015 Muhammad Z. Ahmed, Shao-Jian Li, Xia Xue, Xiang-Jie Yin, Shun-Xiang Ren, Francis M. Jiggins, Jaco M. Greeff, Bao-Li Qiu

2014

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10.1371/journal.ppat.1004473

PLOS Pathogens Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy
November 13, 2014 Julian H. Elliott, Fiona Wightman, Ajantha Solomon, Khader Ghneim, Jeffrey Ahlers, Mark J. Cameron, Miranda Z. Smith, Tim Spelman, James McMahon, Pushparaj Velayudham, Gregor Brown, Janine Roney, Jo Watson, Miles H. Prince, Jennifer F. Hoy, Nicolas Chomont, Rémi Fromentin, Francesco A. Procopio, Joumana Zeidan, Sarah Palmer, Lina Odevall, Ricky W. Johnstone, Ben P. Martin, Elizabeth Sinclair, Steven G. Deeks, Daria J. Hazuda, Paul U. Cameron, Rafick-Pierre Sékaly, Sharon R. Lewin
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10.1371/journal.ppat.1004078

PLOS Pathogens HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality
May 15, 2014 Sergio Serrano-Villar, Talia Sainz, Sulggi A. Lee, Peter W. Hunt, Elizabeth Sinclair, Barbara L. Shacklett, April L. Ferre, Timothy L. Hayes, Ma Somsouk, Priscilla Y. Hsue, Mark L. Van Natta, Curtis L. Meinert, Michael M. Lederman, Hiroyu Hatano, Vivek Jain, Yong Huang, Frederick M. Hecht, Jeffrey N. Martin, Joseph M. McCune, Santiago Moreno, Steven G. Deeks
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10.1371/journal.ppat.1004152

PLOS Pathogens Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response
May 22, 2014 César de la Fuente-Núñez, Fany Reffuveille, Evan F. Haney, Suzana K. Straus, Robert E. W. Hancock
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10.1371/journal.ppat.1003829

PLOS Pathogens A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects
February 20, 2014 Ece A. Mutlu, John Losurdo, Garth Swanson, Basile Siewe, Christopher Forsyth, Audrey French, Patricia DeMarais, Yan Sun, Lars Koenig, Stephen Cox, Phillip Engen, Prachi Chakradeo, Rawan Abbasi, Annika Gorenz, Charles Burns, Alan Landay, Ali Keshavarzian
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10.1371/journal.ppat.1004424

PLOS Pathogens Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90
October 2, 2014 Terence N. Bukong, Fatemeh Momen-Heravi, Karen Kodys, Shashi Bala, Gyongyi Szabo
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10.1371/journal.ppat.1004071

PLOS Pathogens Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing
April 10, 2014 Datsen George Wei, Vicki Chiang, Elizabeth Fyne, Mini Balakrishnan, Tiffany Barnes, Michael Graupe, Joseph Hesselgesser, Alivelu Irrinki, Jeffrey P. Murry, George Stepan, Kirsten M. Stray, Angela Tsai, Helen Yu, Jonathan Spindler, Mary Kearney, Celsa A. Spina, Deborah McMahon, Jacob Lalezari, Derek Sloan, John Mellors, Romas Geleziunas, Tomas Cihlar
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10.1371/journal.ppat.1003932

PLOS Pathogens Unifying Viral Genetics and Human Transportation Data to Predict the Global Transmission Dynamics of Human Influenza H3N2
February 20, 2014 Philippe Lemey, Andrew Rambaut, Trevor Bedford, Nuno Faria, Filip Bielejec, Guy Baele, Colin A. Russell, Derek J. Smith, Oliver G. Pybus, Dirk Brockmann, Marc A. Suchard
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10.1371/journal.ppat.1004230

PLOS Pathogens A Virulent Strain of Deformed Wing Virus (DWV) of Honeybees (Apis mellifera) Prevails after Varroa destructor-Mediated, or In Vitro, Transmission
June 26, 2014 Eugene V. Ryabov, Graham R. Wood, Jessica M. Fannon, Jonathan D. Moore, James C. Bull, Dave Chandler, Andrew Mead, Nigel Burroughs, David J. Evans
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10.1371/journal.ppat.1004048

PLOS Pathogens IFITM3 Restricts Influenza A Virus Entry by Blocking the Formation of Fusion Pores following Virus-Endosome Hemifusion
April 3, 2014 Tanay M. Desai, Mariana Marin, Christopher R. Chin, George Savidis, Abraham L. Brass, Gregory B. Melikyan
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10.1371/journal.ppat.1003856

PLOS Pathogens Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection
January 2, 2014 Jia Liu, Ejuan Zhang, Zhiyong Ma, Weimin Wu, Anna Kosinska, Xiaoyong Zhang, Inga Möller, Pia Seiz, Dieter Glebe, Baoju Wang, Dongliang Yang, Mengji Lu, Michael Roggendorf
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10.1371/journal.ppat.1004543

PLOS Pathogens Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation
December 11, 2014 Alexandra Schuetz, Claire Deleage, Irini Sereti, Rungsun Rerknimitr, Nittaya Phanuphak, Yuwadee Phuang-Ngern, Jacob D. Estes, Netanya G. Sandler, Suchada Sukhumvittaya, Mary Marovich, Surat Jongrakthaitae, Siriwat Akapirat, James L. K. Fletscher, Eugene Kroon, Robin Dewar, Rapee Trichavaroj, Nitiya Chomchey, Daniel C. Douek, Robert J. O′Connell, Viseth Ngauy, Merlin L. Robb, Praphan Phanuphak, Nelson L. Michael, Jean-Louis Excler, Jerome H. Kim, Mark S. de Souza, Jintanat Ananworanich, on behalf of the RV254/SEARCH 010 and RV304/SEARCH 013 Study Groups
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10.1371/journal.ppat.1004010

PLOS Pathogens Lack of Detectable HIV-1 Molecular Evolution during Suppressive Antiretroviral Therapy
March 20, 2014 Mary F. Kearney, Jonathan Spindler, Wei Shao, Sloane Yu, Elizabeth M. Anderson, Angeline O'Shea, Catherine Rehm, Carry Poethke, Nicholas Kovacs, John W. Mellors, John M. Coffin, Frank Maldarelli
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10.1371/journal.ppat.1004045

PLOS Pathogens Coxsackievirus B Exits the Host Cell in Shed Microvesicles Displaying Autophagosomal Markers
April 10, 2014 Scott M. Robinson, Ginger Tsueng, Jon Sin, Vrushali Mangale, Shahad Rahawi, Laura L. McIntyre, Wesley Williams, Nelson Kha, Casey Cruz, Bryan M. Hancock, David P. Nguyen, M. Richard Sayen, Brett J. Hilton, Kelly S. Doran, Anca M. Segall, Roland Wolkowicz, Christopher T. Cornell, J. Lindsay Whitton, Roberta A. Gottlieb, Ralph Feuer
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10.1371/journal.ppat.1004174

PLOS Pathogens Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance
June 12, 2014 Erin K. Sully, Natalia Malachowa, Bradley O. Elmore, Susan M. Alexander, Jon K. Femling, Brian M. Gray, Frank R. DeLeo, Michael Otto, Ambrose L. Cheung, Bruce S. Edwards, Larry A. Sklar, Alexander R. Horswill, Pamela R. Hall, Hattie D. Gresham
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10.1371/journal.ppat.1003847

PLOS Pathogens KSHV 2.0: A Comprehensive Annotation of the Kaposi’s Sarcoma-Associated Herpesvirus Genome Using Next-Generation Sequencing Reveals Novel Genomic and Functional Features
January 16, 2014 Carolina Arias, Ben Weisburd, Noam Stern-Ginossar, Alexandre Mercier, Alexis S. Madrid, Priya Bellare, Meghan Holdorf, Jonathan S. Weissman, Don Ganem
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10.1371/journal.ppat.1004099

PLOS Pathogens Unexpected Role for IL-17 in Protective Immunity against Hypervirulent Mycobacterium tuberculosis HN878 Infection
May 15, 2014 Radha Gopal, Leticia Monin, Samantha Slight, Uzodinma Uche, Emmeline Blanchard, Beth A. Fallert Junecko, Rosalio Ramos-Payan, Christina L. Stallings, Todd A. Reinhart, Jay K. Kolls, Deepak Kaushal, Uma Nagarajan, Javier Rangel-Moreno, Shabaana A. Khader
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10.1371/journal.ppat.1004242

PLOS Pathogens G3BP1, G3BP2 and CAPRIN1 Are Required for Translation of Interferon Stimulated mRNAs and Are Targeted by a Dengue Virus Non-coding RNA
July 3, 2014 Katell Bidet, Dhivya Dadlani, Mariano A. Garcia-Blanco
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10.1371/journal.ppat.1004250

PLOS Pathogens Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset
August 21, 2014 Darryl Falzarano, Emmie de Wit, Friederike Feldmann, Angela L. Rasmussen, Atsushi Okumura, Xinxia Peng, Matthew J. Thomas, Neeltje van Doremalen, Elaine Haddock, Lee Nagy, Rachel LaCasse, Tingting Liu, Jiang Zhu, Jason S. McLellan, Dana P. Scott, Michael G. Katze, Heinz Feldmann, Vincent J. Munster
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10.1371/journal.ppat.1004067

PLOS Pathogens Prophenoloxidase Activation Is Required for Survival to Microbial Infections in Drosophila
May 1, 2014 Olivier Binggeli, Claudine Neyen, Mickael Poidevin, Bruno Lemaitre
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10.1371/journal.ppat.1004369

PLOS Pathogens Symbionts Commonly Provide Broad Spectrum Resistance to Viruses in Insects: A Comparative Analysis of Wolbachia Strains
September 18, 2014 Julien Martinez, Ben Longdon, Simone Bauer, Yuk-Sang Chan, Wolfgang J. Miller, Kostas Bourtzis, Luis Teixeira, Francis M. Jiggins
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10.1371/journal.ppat.1004251

PLOS Pathogens T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection
July 17, 2014 Marcus Buggert, Johanna Tauriainen, Takuya Yamamoto, Juliet Frederiksen, Martin A. Ivarsson, Jakob Michaëlsson, Ole Lund, Bo Hejdeman, Marianne Jansson, Anders Sönnerborg, Richard A. Koup, Michael R. Betts, Annika C. Karlsson
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10.1371/journal.ppat.1004053

PLOS Pathogens Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection
April 3, 2014 Christoph Schneider, Samuel P. Nobs, Alex K. Heer, Michael Kurrer, Glynis Klinke, Nico van Rooijen, Johannes Vogel, Manfred Kopf
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10.1371/journal.ppat.1004050

PLOS Pathogens Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation
April 10, 2014 Jeanette Wagener, R. K. Subbarao Malireddi, Megan D. Lenardon, Martin Köberle, Simon Vautier, Donna M. MacCallum, Tilo Biedermann, Martin Schaller, Mihai G. Netea, Thirumala-Devi Kanneganti, Gordon D. Brown, Alistair J. P. Brown, Neil A. R. Gow
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10.1371/journal.ppat.1003946

PLOS Pathogens Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth
February 20, 2014 Sarah A. Stanley, Amy K. Barczak, Melanie R. Silvis, Samantha S. Luo, Kimberly Sogi, Martha Vokes, Mark-Anthony Bray, Anne E. Carpenter, Christopher B. Moore, Noman Siddiqi, Eric J. Rubin, Deborah T. Hung
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10.1371/journal.ppat.1003996

PLOS Pathogens Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi
March 13, 2014 Pranab K. Mukherjee, Jyotsna Chandra, Mauricio Retuerto, Masoumeh Sikaroodi, Robert E. Brown, Richard Jurevic, Robert A. Salata, Michael M. Lederman, Patrick M. Gillevet, Mahmoud A. Ghannoum
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10.1371/journal.ppat.1003853

PLOS Pathogens Loss of Circulating CD4 T Cells with B Cell Helper Function during Chronic HIV Infection
January 30, 2014 Kristin L. Boswell, Robert Paris, Eli Boritz, David Ambrozak, Takuya Yamamoto, Sam Darko, Kaska Wloka, Adam Wheatley, Sandeep Narpala, Adrian McDermott, Mario Roederer, Richard Haubrich, Mark Connors, Julie Ake, Daniel C. Douek, Jerome Kim, Richard A. Koup, Constantinos Petrovas
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10.1371/journal.ppat.1004508

PLOS Pathogens Genetics, Receptor Binding Property, and Transmissibility in Mammals of Naturally Isolated H9N2 Avian Influenza Viruses
November 20, 2014 Xuyong Li, Jianzhong Shi, Jing Guo, Guohua Deng, Qianyi Zhang, Jinliang Wang, Xijun He, Kaicheng Wang, Jiming Chen, Yuanyuan Li, Jun Fan, Huiui Kong, Chunyang Gu, Yuantao Guan, Yasuo Suzuki, Yoshihiro Kawaoka, Liling Liu, Yongping Jiang, Guobin Tian, Yanbing Li, Zhigao Bu, Hualan Chen
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10.1371/journal.ppat.1003993

PLOS Pathogens Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway
March 13, 2014 Nathan L. Bowers, E. Scott Helton, Richard P. H. Huijbregts, Paul A. Goepfert, Sonya L. Heath, Zdenek Hel
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10.1371/journal.ppat.1004441

PLOS Pathogens Human Cytomegalovirus Drives Epigenetic Imprinting of the IFNG Locus in NKG2C^hi Natural Killer Cells
October 16, 2014 Merlin Luetke-Eversloh, Quirin Hammer, Pawel Durek, Karl Nordström, Gilles Gasparoni, Matthias Pink, Alf Hamann, Jörn Walter, Hyun-Dong Chang, Jun Dong, Chiara Romagnani
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10.1371/journal.ppat.1004321

PLOS Pathogens Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity
August 21, 2014 Melissa Starkey, Francois Lepine, Damien Maura, Arunava Bandyopadhaya, Biljana Lesic, Jianxin He, Tomoe Kitao, Valeria Righi, Sylvain Milot, Aria Tzika, Laurence Rahme
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10.1371/journal.ppat.1004287

PLOS Pathogens Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes
August 14, 2014 Richard Brad Jones, Rachel O'Connor, Stefanie Mueller, Maria Foley, Gregory L. Szeto, Dan Karel, Mathias Lichterfeld, Colin Kovacs, Mario A. Ostrowski, Alicja Trocha, Darrell J. Irvine, Bruce D. Walker
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10.1371/journal.ppat.1004210

PLOS Pathogens Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver
June 26, 2014 Juandy Jo, Anthony T. Tan, James E. Ussher, Elena Sandalova, Xin-Zi Tang, Alfonso Tan-Garcia, Natalie To, Michelle Hong, Adeline Chia, Upkar S. Gill, Patrick T. Kennedy, Kai Chah Tan, Kang Hoe Lee, Gennaro De Libero, Adam J. Gehring, Christian B. Willberg, Paul Klenerman, Antonio Bertoletti
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10.1371/journal.ppat.1004032

PLOS Pathogens Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages
March 20, 2014 Moses T. Bility, Liang Cheng, Zheng Zhang, Yan Luan, Feng Li, Liqun Chi, Liguo Zhang, Zhengkun Tu, Yanhang Gao, Yangxin Fu, Junqi Niu, Fusheng Wang, Lishan Su
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10.1371/journal.ppat.1003883

PLOS Pathogens The Arabidopsis miR472-RDR6 Silencing Pathway Modulates PAMP- and Effector-Triggered Immunity through the Post-transcriptional Control of Disease Resistance Genes
January 16, 2014 Martine Boccara, Alexis Sarazin, Odon Thiébeauld, Florence Jay, Olivier Voinnet, Lionel Navarro, Vincent Colot
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10.1371/journal.ppat.1004082

PLOS Pathogens HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon
May 1, 2014 Michael A. Chattergoon, Rachel Latanich, Jeffrey Quinn, Matthew E. Winter, Robert W. Buckheit 3rd, Joel N. Blankson, Drew Pardoll, Andrea L. Cox
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10.1371/journal.ppat.1004398

PLOS Pathogens Chromobacterium Csp_P Reduces Malaria and Dengue Infection in Vector Mosquitoes and Has Entomopathogenic and In Vitro Anti-pathogen Activities
October 23, 2014 Jose Ramirez, Sarah Short, Ana Bahia, Raúl Saraiva, Yuemei Dong, Seokyoung Kang, Abhai Tripathi, Godfree Mlambo, George Dimopoulos
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10.1371/journal.ppat.1003903

PLOS Pathogens Origin, Migration Routes and Worldwide Population Genetic Structure of the Wheat Yellow Rust Pathogen Puccinia striiformis f.sp. tritici
January 23, 2014 Sajid Ali, Pierre Gladieux, Marc Leconte, Angélique Gautier, Annemarie F. Justesen, Mogens S. Hovmøller, Jérôme Enjalbert, Claude de Vallavieille-Pope
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10.1371/journal.ppat.1004459

PLOS Pathogens Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly
October 30, 2014 Amanda J. Price, David A. Jacques, William A. McEwan, Adam J. Fletcher, Sebastian Essig, Jason W. Chin, Upul D. Halambage, Christopher Aiken, Leo C. James
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10.1371/journal.ppat.1003940

PLOS Pathogens Inflammatory Monocytes Orchestrate Innate Antifungal Immunity in the Lung
February 20, 2014 Vanessa Espinosa, Anupam Jhingran, Orchi Dutta, Shinji Kasahara, Robert Donnelly, Peicheng Du, Jeffrey Rosenfeld, Ingrid Leiner, Chiann-Chyi Chen, Yacov Ron, Tobias M. Hohl, Amariliz Rivera
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10.1371/journal.ppat.1004566

PLOS Pathogens Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells
December 18, 2014 David Olagnier, Suraj Peri, Courtney Steel, Nadine van Montfoort, Cindy Chiang, Vladimir Beljanski, Michael Slifker, Zhong He, Carmen N. Nichols, Rongtuan Lin, Siddharth Balachandran, John Hiscott
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10.1371/journal.ppat.1004386

PLOS Pathogens Dengue Viruses Are Enhanced by Distinct Populations of Serotype Cross-Reactive Antibodies in Human Immune Sera
October 2, 2014 Ruklanthi de Alwis, Katherine L. Williams, Michael A. Schmid, Chih-Yun Lai, Bhumi Patel, Scott A. Smith, James E. Crowe, Wei-Kung Wang, Eva Harris, Aravinda M. de Silva
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10.1371/journal.ppat.1004323

PLOS Pathogens On the Front Line: Quantitative Virus Dynamics in Honeybee (Apis mellifera L.) Colonies along a New Expansion Front of the Parasite Varroa destructor
August 21, 2014 Fanny Mondet, Joachim R. de Miranda, Andre Kretzschmar, Yves Le Conte, Alison R. Mercer
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10.1371/journal.ppat.1003831

PLOS Pathogens A Single Amino Acid in the Stalk Region of the H1N1pdm Influenza Virus HA Protein Affects Viral Fusion, Stability and Infectivity
January 2, 2014 Christopher R. Cotter, Hong Jin, Zhongying Chen
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10.1371/journal.ppat.1004090

PLOS Pathogens High-Efficiency Targeted Editing of Large Viral Genomes by RNA-Guided Nucleases
May 1, 2014 Yanwei Bi, Le Sun, Dandan Gao, Chen Ding, Zhihua Li, Yadong Li, Wei Cun, Qihan Li
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10.1371/journal.ppat.1003902

PLOS Pathogens Reengineering Redox Sensitive GFP to Measure Mycothiol Redox Potential of Mycobacterium tuberculosis during Infection
January 30, 2014 Ashima Bhaskar, Manbeena Chawla, Mansi Mehta, Pankti Parikh, Pallavi Chandra, Devayani Bhave, Dhiraj Kumar, Kate S. Carroll, Amit Singh
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10.1371/journal.ppat.1004507

PLOS Pathogens The Toll-Dorsal Pathway Is Required for Resistance to Viral Oral Infection in Drosophila
December 4, 2014 Álvaro Gil Ferreira, Huw Naylor, Sara Santana Esteves, Inês Silva Pais, Nelson Eduardo Martins, Luis Teixeira
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10.1371/journal.ppat.1004162

PLOS Pathogens Large Scale RNAi Reveals the Requirement of Nuclear Envelope Breakdown for Nuclear Import of Human Papillomaviruses
May 29, 2014 Inci Aydin, Susanne Weber, Berend Snijder, Pilar Samperio Ventayol, Andreas Kühbacher, Miriam Becker, Patricia M. Day, John T. Schiller, Michael Kann, Lucas Pelkmans, Ari Helenius, Mario Schelhaas
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10.1371/journal.ppat.1004079

PLOS Pathogens Exposure-Dependent Control of Malaria-Induced Inflammation in Children
April 17, 2014 Silvia Portugal, Jacqueline Moebius, Jeff Skinner, Safiatou Doumbo, Didier Doumtabe, Youssounou Kone, Seydou Dia, Kishore Kanakabandi, Daniel Sturdevant, Kimmo Virtaneva, Stephen Porcella, Shanping Li, Ogobara Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Peter Crompton
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10.1371/journal.ppat.1004464

PLOS Pathogens MicroRNAs Suppress NB Domain Genes in Tomato That Confer Resistance to Fusarium oxysporum
October 16, 2014 Shouqiang Ouyang, Gyungsoon Park, Hagop S. Atamian, Cliff S. Han, Jason E. Stajich, Isgouhi Kaloshian, Katherine A. Borkovich
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10.1371/journal.ppat.1004211

PLOS Pathogens Systematic Phenotyping of a Large-Scale Candida glabrata Deletion Collection Reveals Novel Antifungal Tolerance Genes
June 19, 2014 Tobias Schwarzmüller, Biao Ma, Ekkehard Hiller, Fabian Istel, Michael Tscherner, Sascha Brunke, Lauren Ames, Arnaud Firon, Brian Green, Vitor Cabral, Marina Marcet-Houben, Ilse D. Jacobsen, Jessica Quintin, Katja Seider, Ingrid Frohner, Walter Glaser, Helmut Jungwirth, Sophie Bachellier-Bassi, Murielle Chauvel, Ute Zeidler, Dominique Ferrandon, Toni Gabaldón, Bernhard Hube, Christophe d'Enfert, Steffen Rupp, Brendan Cormack, Ken Haynes, Karl Kuchler
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10.1371/journal.ppat.1004405

PLOS Pathogens Insights into Vibrio cholerae Intestinal Colonization from Monitoring Fluorescently Labeled Bacteria
October 2, 2014 Yves A. Millet, David Alvarez, Simon Ringgaard, Ulrich H. von Andrian, Brigid M. Davis, Matthew K. Waldor
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10.1371/journal.ppat.1004509

PLOS Pathogens Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability
November 20, 2014 Beatriz Escudero-Pérez, Valentina Volchkova, Olga Dolnik, Philip Lawrence, Viktor Volchkov
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10.1371/journal.ppat.1003921

PLOS Pathogens Suppression of RNA Silencing by a Plant DNA Virus Satellite Requires a Host Calmodulin-Like Protein to Repress RDR6 Expression
February 6, 2014 Fangfang Li, Changjun Huang, Xueping Zhou, Zhenghe Li
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10.1371/journal.ppat.1003995

PLOS Pathogens Modulation of Phagosomal pH by Candida albicans Promotes Hyphal Morphogenesis and Requires Stp2p, a Regulator of Amino Acid Transport
March 13, 2014 Slavena Vylkova, Michael C. Lorenz
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10.1371/journal.ppat.1003928

PLOS Pathogens Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection
February 20, 2014 Alexandre Gouzy, Gérald Larrouy-Maumus, Daria Bottai, Florence Levillain, Alexia Dumas, Joshua B. Wallach, Irène Caire-Brandli, Chantal de Chastellier, Ting-Di Wu, Renaud Poincloux, Roland Brosch, Jean-Luc Guerquin-Kern, Dirk Schnappinger, Luiz Pedro Sório de Carvalho, Yannick Poquet, Olivier Neyrolles
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10.1371/journal.ppat.1004065

PLOS Pathogens Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses
April 3, 2014 Jeff Butler, Kathryn A. Hooper, Stephen Petrie, Raphael Lee, Sebastian Maurer-Stroh, Lucia Reh, Teagan Guarnaccia, Chantal Baas, Lumin Xue, Sophie Vitesnik, Sook-Kwan Leang, Jodie McVernon, Anne Kelso, Ian G. Barr, James M. McCaw, Jesse D. Bloom, Aeron C. Hurt
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10.1371/journal.ppat.1004358

PLOS Pathogens RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms
September 25, 2014 Yue Qin, Mao-Tian Zhou, Ming-Ming Hu, Yun-Hong Hu, Jing Zhang, Lin Guo, Bo Zhong, Hong-Bing Shu
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10.1371/journal.ppat.1003864

PLOS Pathogens IFNγ/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children
January 9, 2014 Prasanna Jagannathan, Ijeoma Eccles-James, Katherine Bowen, Felistas Nankya, Ann Auma, Samuel Wamala, Charles Ebusu, Mary Muhindo, Emmanuel Arinaitwe, Jessica Briggs, Bryan Greenhouse, Jordan Tappero, Moses Kamya, Grant Dorsey, Margaret Feeney
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10.1371/journal.ppat.1004462

PLOS Pathogens IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis
November 6, 2014 Silvia Moretti, Silvia Bozza, Vasilis Oikonomou, Giorgia Renga, Andrea Casagrande, Rossana G. Iannitti, Matteo Puccetti, Cecilia Garlanda, Soohyun Kim, Suzhao Li, Frank L. van de Veerdonk, Charles A. Dinarello, Luigina Romani
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10.1371/journal.ppat.1004487

PLOS Pathogens ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence
November 6, 2014 Dawoon Chung, Bridget M. Barker, Charles C. Carey, Brittney Merriman, Ernst R. Werner, Beatrix E. Lechner, Sourabh Dhingra, Chao Cheng, Wenjie Xu, Sara J. Blosser, Kengo Morohashi, Aurélien Mazurie, Thomas K. Mitchell, Hubertus Haas, Aaron P. Mitchell, Robert A. Cramer
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10.1371/journal.ppat.1003886

PLOS Pathogens Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen
January 16, 2014 Nathaniel G. Jones, Elizabeth B. Thomas, Elaine Brown, Nicholas J. Dickens, Tansy C. Hammarton, Jeremy C. Mottram

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