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PLOS ONE is delighted to present this Collection of Open Soft Robotics Research. Largely inspired by the way many living organisms move and adapt their shape to their surroundings, soft robots have been designed and constructed with compliant, deformable and variable stiffness materials, sensors and actuators. Biomimicry has allowed soft robots to acquire novel features such as stretchability, growth, morphing, self-reconfigurability, self-healing and edibility. Their impact has grown in a variety of sectors, such as search and rescue, exploration, rehabilitation medicine and surgery, prostheses and exoskeletons. This collection is aimed at providing an inclusive platform for researchers from a broad range of disciplines to explore this vital and timely topic.