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Targeted Anticancer Therapies and Precision Medicine in Cancer

Published January 30, 2020 Calls for Papers Collections

While the rate of death from cancer has been declining since the 1990s, an estimated 9.6 million people died from cancer in 2018, making it the second-leading cause of death worldwide. There is clearly still an unmet need to improve cancer detection and bring new treatment options to patients. These articles in this Collection represent diverse facets of ongoing efforts in this area, where general knowledge of cancers serves to inform individual patient’s care, and - at the same time - particulars from individual cancer cases contribute to improved resolution of our general knowledge pool.

Image Credit: https://www.flickr.com/photos/nihgov/27786378828/

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Guest Editors (PLOS ONE)
PLOS ONE Collection
Guest Editors (PLOS Computational Biology)
PLOS Computational Biology Collection

Guest Editors (PLOS ONE)

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PLOS ONE

The PLOS ONE Blog Introducing the Targeted Anticancer Therapies and Precision Medicine in Cancer Collection | EveryONE: The PLOS ONE blog
November 18, 2019 PLOS ONE
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https://collections.plos.org/s/targeted-anticancer-therapies

Andrew Cherniack Andrew Cherniack
March 13, 2019 Guest Editor, PLOS ONE
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https://collections.plos.org/s/targeted-anticancer-therapies

Anette Duensing Anette Duensing
March 13, 2019 Guest Editor, PLOS ONE
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https://collections.plos.org/s/targeted-anticancer-therapies

Steven G. Gray Steven G. Gray
March 13, 2019 Guest Editor, PLOS ONE
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https://collections.plos.org/s/targeted-anticancer-therapies

Sunil Krishnan Sunil Krishnan
March 13, 2019 Guest Editor, PLOS ONE
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https://collections.plos.org/s/targeted-anticancer-therapies

Chandan Kumar-Sinha Chandan Kumar-Sinha
March 13, 2019 Guest Editor, PLOS ONE
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https://collections.plos.org/s/targeted-anticancer-therapies

Gayle E. Woloschak Gayle E. Woloschak
March 13, 2019 Guest Editor, PLOS ONE

PLOS ONE Collection

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PLOS ONE Assessment of Acyl-CoA Cholesterol Acyltransferase (ACAT-1) Role in Ovarian Cancer Progression – An in vitro, Study
January 24, 2020 Vijayalakshmi Ayyagari, Xinjia Wang, Paula Diaz-Sylvester, Kathleen Groesch, Laurent Brard
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10.1371/journal.pone.0226917

PLOS ONE The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
January 13, 2020 Matthew Brown, Wanbin Zhang, Deyue Yan, Rajath Kenath, Le Le, He Wang, Daniel Delitto, David Ostrov, Keith Robertson, Chen Liu, Kien Pham
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Flickr

PLOS ONE Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates
December 31, 2019 John C. Zwaagstra, Traian Sulea, Jason Baardsnes, Stevo Radinovic, Yuneivy Cepero-Donates, Alma Robert, Maureen D. O’Connor-McCourt, Ilia A. Tikhomirov, Maria Luz. Jaramillo
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PLOS ONE Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer
December 31, 2019 Fumiaki Watanabe, Koichi Suzuki, Sawako Tamaki, Iku Abe, Yuhei Endo, Yuji Takayama, Hideki Ishikawa, Nao Kakizawa, Masaaki Saito, Kazushige Futsuhara, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama
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Pixabay

PLOS ONE Predicting breast cancer risk using personal health data and machine learning models
December 27, 2019 Gigi F. Stark, Gregory R. Hart, Bradley J. Nartowt, Jun Deng
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Pixabay

PLOS ONE Tankyrase inhibition sensitizes cells to CDK4 blockade
December 31, 2019 Miguel Foronda, Yusuke Tarumoto, Emma M. Schatoff, Benjamin I. Leach, Bianca J. Diaz, Jill Zimmerman, Sukanya Goswami, Michael Shusterman, Christopher R. Vakoc, Lukas E. Dow
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10.1371/journal.pone.0225249

PLOS ONE Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass
November 18, 2019 Douglas Nogueira Perez Oliveira, Anting Liu Carlsen, Niels H. H. Heegaard, Kira Philipsen Prahm, Ib Jarle Christensen, Claus K. Høgdall, Estrid V. Høgdall
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10.1371/journal.pone.0224379

PLOS ONE Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing
November 25, 2019 You Jin Chun, Jae Woo Choi, Min Hee Hong, Dongmin Jung, Hyeonju Son, Eun Kyung Cho, Young Joo Min, Sang-We Kim, Keunchil Park, Sung Sook Lee, Sangwoo Kim, Hye Ryun Kim, Korean Lung Cancer Consortium (KLCC) , Byoung Chul Cho
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PLOS ONE Reversed metabolic reprogramming as a measure of cancer treatment efficacy in rat C6 glioma model
December 12, 2019 Keshav Datta, Mette H. Lauritzen, Milton Merchant, Taichang Jang, Shie-Chau Liu, Ralph Hurd, Lawrence Recht, Daniel M. Spielman
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Pixabay

PLOS ONE Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines
November 27, 2019 Takahiro Isono, Masafumi Suzaki
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Pixabay

PLOS ONE Formation of a structurally-stable conformation by the intrinsically disordered MYC:TRRAP complex
December 2, 2019 Edmond J. Feris, John W. Hinds, Michael D. Cole
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10.1371/journal.pone.0214901

PLOS ONE Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
September 20, 2019 Kirti Kandhwal Chahal, Jie Li, Irina Kufareva, Milind Parle, Donald L. Durden, Robert J. Wechsler-Reya, Clark C. Chen, Ruben Abagyan
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10.1371/journal.pone.0215886

PLOS ONE Antitumor activity of a novel dual functional podophyllotoxin derivative involved PI3K/AKT/mTOR pathway
September 26, 2019 Yongli Li, Tengfei Huang, Yun Fu, Tingting Wang, Tiesuo Zhao, Sheng Guo, Yanjie Sun, Yun Yang, Changzheng Li
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Pixabay

PLOS ONE Discordance of epidermal growth factor receptor mutation between primary lung tumor and paired distant metastases in non-small cell lung cancer: A systematic review and meta-analysis
June 19, 2019 Chia Ching Lee, Char Loo Tan, Wee Yao Koh, Cheng Nang Leong, Jeremy Chee Seong Tey, Ivan Weng Keong Tham, Yu Yang Soon
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PLOS ONE LINE-1 hypomethylation in human hepatocellular carcinomas correlates with shorter overall survival and CIMP phenotype
May 6, 2019 Sumadi Lukman Anwar, Britta Hasemeier, Elisa Schipper, Arndt Vogel, Hans Kreipe, Ulrich Lehmann
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10.1371/journal.pone.0218642

PLOS ONE A machine learning algorithm predicts molecular subtypes in pancreatic ductal adenocarcinoma with differential response to gemcitabine-based versus FOLFIRINOX chemotherapy
October 2, 2019 Georgios Kaissis, Sebastian Ziegelmayer, Fabian Lohöfer, Katja Steiger, Hana Algül, Alexander Muckenhuber, Hsi-Yu Yen, Ernst Rummeny, Helmut Friess, Roland Schmid, Wilko Weichert, Jens T. Siveke, Rickmer Braren
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PLOS ONE Improved detection of prostate cancer using a magneto-nanosensor assay for serum circulating autoantibodies
August 12, 2019 Lingyun Xu, Jung-Rok Lee, Shiying Hao, Xuefeng Bruce Ling, James D. Brooks, Shan X. Wang, Sanjiv Sam Gambhir
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10.1371/journal.pone.0219494

PLOS ONE Olfactomedin 4 (OLFM4) expression is associated with nodal metastases in esophageal adenocarcinoma
July 8, 2019 Lucia Suzuki, Fiebo J. C. ten Kate, Annieke W. Gotink, Hans Stoop, Michail Doukas, Daan Nieboer, Manon C. W. Spaander, Jan J. B. van Lanschot, Bas P. L. van Wijnhoven, Arjun D. Koch, Marco J. Bruno, Leendert H. J. Looijenga, Katharina Biermann
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Pixabay

PLOS ONE Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform
September 25, 2019 Yoon-Sim Yap, Man Chun Leong, Yong Wei Chua, Kiley Wei Jen Loh, Guek Eng Lee, Elaine Hsuen Lim, Rebecca Dent, Raymond Chee Hui Ng, John Heng-Chi Lim, Garima Singh, Angela Tan, Guofeng Guan, Andrew Wu, Yi Fang Lee, Ali Asgar S. Bhagat, Darren Wan-Teck Lim
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PLOS ONE Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia
November 13, 2019 Gayle Pouliot, James Degar, Laura Hinze, Bose Kochupurakkal, Chau Vo, Melissa Burns, Lisa Moreau, Chirag Ganesa, Justine Roderick, Sofie Peirs, Bjorn Menten, Mignon Loh, Stephen Hunger, Lewis Silverman, Marian Harris, Kristen Stevenson, David Weinstock, Andrew Weng, Michelle Kelliher, Pieter Van Vlierberghe, Alan D'Andrea, Alejandro Gutierrez
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10.1371/journal.pone.0221413

PLOS ONE High expression of the vacuole membrane protein 1 (VMP1) is a potential marker of poor prognosis in HER2 positive breast cancer
August 23, 2019 Arsalan Amirfallah, Adalgeir Arason, Hjorleifur Einarsson, Eydis Thorunn Gudmundsdottir, Edda Sigridur Freysteinsdottir, Kristrun Audur Olafsdottir, Oskar Thor Johannsson, Bjarni Agnar Agnarsson, Rosa Bjork Barkardottir, Inga Reynisdottir
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10.1371/journal.pone.0221952

PLOS ONE Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms
September 6, 2019 Vagisha Ravi, Achuthamangalam B. Madhankumar, Thomas Abraham, Becky Slagle-Webb, James R. Connor
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10.1371/journal.pone.0221635

PLOS ONE A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression
October 10, 2019 Emilie A. Chapeau, Emeline Mandon, Jason Gill, Vincent Romanet, Nicolas Ebel, Violetta Powajbo, Rita Andraos-Rey, Zhiyan Qian, Miltos Kininis, Sabine Zumstein-Mecker, Moriko Ito, Nancy E. Hynes, Ralph Tiedt, Francesco Hofmann, Leonid Eshkind, Ernesto Bockamp, Bernd Kinzel, Matthias Mueller, Masato Murakami, Fabienne Baffert, Thomas Radimerski
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10.1371/journal.pone.0222228

PLOS ONE Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines
September 24, 2019 Darcy Welch, Elliot Kahen, Brooke Fridley, Andrew S. Brohl, Christopher L. Cubitt, Damon R. Reed
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Pixabay

PLOS ONE Class III β-tubulin expression as a predictor of docetaxel-resistance in metastatic castration-resistant prostate cancer
October 28, 2019 Lucas Maahs, Bertha E. Sanchez, Nilesh Gupta, Meredith Van Harn, Evelyn R. Barrack, Prem-veer Reddy, Clara Hwang
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10.1371/journal.pone.0223225

PLOS ONE MET as resistance factor for afatinib therapy and motility driver in gastric cancer cells
September 26, 2019 Karolin Ebert, Julian Mattes, Thomas Kunzke, Gwen Zwingenberger, Birgit Luber
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10.1371/journal.pone.0223112

PLOS ONE Analytical validation of the Target Selector ctDNA platform featuring single copy detection sensitivity for clinically actionable EGFR, BRAF, and KRAS mutations
October 3, 2019 Jason C. Poole, Shan-Fu Wu, Timothy T. Lu, Cecile Rose T. Vibat, Anh Pham, Errin Samuelsz, Manisha Patel, Jeffrey Chen, Tony Daher, Veena M. Singh, Lyle J. Arnold
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10.1371/journal.pone.0223639

PLOS ONE Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma
October 9, 2019 Gabrielle Choonoo, Aurora S. Blucher, Samuel Higgins, Mitzi Boardman, Sophia Jeng, Christina Zheng, James Jacobs, Ashley Anderson, Steven Chamberlin, Nathaniel Evans, Myles Vigoda, Benjamin Cordier, Jeffrey W. Tyner, Molly Kulesz-Martin, Shannon K. McWeeney, Ted Laderas
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Pixabay

PLOS ONE Measurable residual disease monitoring for patients with acute myeloid leukemia following hematopoietic cell transplantation using error corrected hybrid capture next generation sequencing
October 28, 2019 Vidya Balagopal, Andrew Hantel, Sabah Kadri, George Steinhardt, Chao Jie Zhen, Wenjun Kang, Pankhuri Wanjari, Lauren L. Ritterhouse, Wendy Stock, Jeremy P. Segal
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10.1371/journal.pone.0224267

PLOS ONE Integrated pan-cancer gene expression and drug sensitivity analysis reveals SLFN11 mRNA as a solid tumor biomarker predictive of sensitivity to DNA-damaging chemotherapy
November 4, 2019 Kevin Shee, Jason D. Wells, Amanda Jiang, Todd W. Miller
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10.1371/journal.pone.0218897

PLOS ONE Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors
July 5, 2019 Thomas W. Miller, Joshua D. Amason, Elsa D. Garcin, Laurence Lamy, Patricia K. Dranchak, Ryan Macarthur, John Braisted, Jeffrey S. Rubin, Teresa L. Burgess, Catherine L. Farrell, David D. Roberts, James Inglese

Guest Editors (PLOS Computational Biology)

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https://collections.plos.org/s/targeted-anticancer-therapies

Aaron Goldman Aaron Goldman
March 13, 2019 Guest Editor, PLOS Computational Biology
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https://collections.plos.org/s/targeted-anticancer-therapies

Feixiong Cheng Feixiong Cheng
March 13, 2019 Guest Editor, PLOS Computational Biology
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https://collections.plos.org/s/targeted-anticancer-therapies

Anna Panchenko Anna Panchenko
March 13, 2019 Guest Editor, PLOS Computational Biology
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https://collections.plos.org/s/targeted-anticancer-therapies

Benjamin Ribba Benjamin Ribba
March 13, 2019 Guest Editor, PLOS Computational Biology

PLOS Computational Biology Collection

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10.1371/journal.pcbi.1007485

PLOS Computational Biology Alterations of the pro-survival Bcl-2 protein interactome in breast cancer at the transcriptional, mutational and structural level
December 11, 2019 Simon Kønig, Vendela Rissler, Thilde Terkelsen, Matteo Lambrughi, Elena Papaleo
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10.1371/journal.pcbi.1007495

PLOS Computational Biology Determinants of combination GM-CSF immunotherapy and oncolytic virotherapy success identified through in silico treatment personalization
November 27, 2019 Tyler Cassidy, Morgan Craig
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10.1371/journal.pcbi.1007520

PLOS Computational Biology A novel network control model for identifying personalized driver genes in cancer
November 25, 2019 WeiFeng Guo, Shao-Wu Zhang, Tao Zeng, Yan Li, Jianxi Gao, Luonan Chen

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