Purpose: To evaluate the diagnostic value of symptoms used by daycares and schools to screen children and adolescents for SARS-CoV-2…
Biology & Life Sciences
COVID-19 pandemic (2019-21)
This Collection of articles highlights all content published across the PLOS journals relating to the COVID-19 pandemic in 2019-21.
PLOS is committed to disseminating research as quickly as possible, particularly in public health emergencies.
All articles published in any PLOS journal are Open Access free of charge to all readers.
Image Credit: US NIH/Public domain (CC-0) and Senado Federal/Flickr (CC-BY)
Clinical Epidemiology and Care
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PLOS ONE Diagnostic value of symptoms for pediatric SARS-CoV-2 infection in a primary care setting
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Image creditSARS-CoV-2 text with marker by Jernej Furman, CC BY 2.0PLOS ONE Evaluation of SARS-CoV-2 in semen, seminal plasma, and spermatozoa pellet of COVID-19 patients in the acute stage of infection
To date, there is limited information about the presence of SARS-CoV-2 in semen especially in the acute phase of the infection. While…
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PLOS ONE ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study
Background: We investigated the prevalence of ECG abnormalities and their association with mortality, organ dysfunction and cardiac…
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Image creditCovid19 radio by Mike Finn, CC BY 2.0PLOS ONE Understanding the social drivers of antibiotic use during COVID-19 in Bangladesh: Implications for reduction of antimicrobial resistance
Antimicrobial resistance (AMR) is a global public health crisis that is now impacted by the COVID-19 pandemic. Little is known how…
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PLOS ONE Association of ABO blood group with COVID-19 severity, acute phase reactants and mortality
Introduction: Coronavirus disease 2019 (COVID-19) is the ongoing pandemic with multitude of manifestations and association of ABO blood…
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Image creditShroff Eye Hospital by RubyGoes, CC BY 2.0PLOS ONE National Early Warning Score 2 (NEWS2) to predict poor outcome in hospitalised COVID-19 patients in India
Background: While several parameters have emerged as predictors of prognosis of COVID-19, a simple clinical score at baseline might help…
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Image creditHand drawing a chart with COVID-19 text by Jernej Furman, CC BY 2.0PLOS ONE ‘It felt like a black hole, great uncertainty, but we have to take care for our patients’–Qualitative findings on the effects of the COVID-19 pandemic on specialist palliative home care
Background: The COVID-19 pandemic has affected health care systems worldwide. Multidisciplinary teams provide specialist palliative home…
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Image creditCovid-19 word cloud by EpicTop10.com, CC BY 2.0PLOS ONE Clinical features of 375 COVID-19 cases imported from Russia through the Suifenhe port and countermeasures
Background and objectives: At present, the focus of the fighting against COVID-19 in China is shifting to strictly prevent the entrance of…
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PLOS ONE Impact of the early COVID-19 pandemic on outcomes in a rural Ugandan neonatal unit: A retrospective cohort study
Background: During the early COVID-19 pandemic travel in Uganda was tightly restricted which affected demand for and access to care for…
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PLOS Computational Biology Modeling the onset of symptoms of COVID-19: Effects of SARS-CoV-2 variant
Identifying order of symptom onset of infectious diseases might aid in differentiating symptomatic infections earlier in a population…
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PLOS ONE Potential SARS-CoV-2 infectiousness among asymptomatic healthcare workers
A majority of SARS-CoV-2 infections are transmitted from a minority of infected subjects, some of which may be symptomatic or…
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PLOS ONE Factors of parental COVID-19 vaccine hesitancy: A cross sectional study in Japan
The eligibility of COVID-19 vaccines has been expanded to children aged 12 and above in several countries including Japan, and there is a…
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PLOS Medicine Vaccine effectiveness against SARS-CoV-2 infection, hospitalization, and death when combining a first dose ChAdOx1 vaccine with a subsequent mRNA vaccine in Denmark: A nationwide population-based cohort study
Background: The recommendations in several countries to stop using the ChAdOx1 vaccine has led to vaccine programs combining different…
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PLOS ONE Innovations, contestations and fragilities of the health system response to COVID-19 in the Gauteng Province of South Africa
Background: Gauteng province, with 26.3% of South Africa’s population, is the commercial and industrial powerhouse of the country. During…
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PLOS ONE Modelling RT-qPCR cycle-threshold using digital PCR data for implementing SARS-CoV-2 viral load studies
Objectives: To exploit the features of digital PCR for implementing SARS-CoV-2 observational studies by reliably including the viral load…
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PLOS Pathogens The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease
The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 disease, has killed over five million people worldwide as of December…
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PLOS Pathogens SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Currently, as dangerous mutations…
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PLOS Neglected Tropical Diseases The impact of COVID-19 on clinical research for Neglected Tropical Diseases (NTDs): A case study of bubonic plague
Background: Among the many collaterals of the COVID-19 pandemic is the disruption of health services and vital clinical research. COVID-19…
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PLOS ONE Eculizumab in patients with severe coronavirus disease 2019 (COVID-19) requiring continuous positive airway pressure ventilator support: Retrospective cohort study
Background: Complement activation contributes to lung dysfunction in coronavirus disease 2019 (COVID-19). We assessed whether C5 blockade…
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PLOS Biology Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses
The pandemic spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of Coronavirus Disease 2019…
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PLOS Computational Biology SWIFT: A deep learning approach to prediction of hypoxemic events in critically-Ill patients using SpO2 waveform prediction
Hypoxemia is a significant driver of mortality and poor clinical outcomes in conditions such as brain injury and cardiac arrest in…
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PLOS ONE Adverse events following the first dose of Covishield (ChAdOx1 nCoV-19) vaccination among health workers in selected districts of central and western Nepal: A cross-sectional study
Introduction: The study aimed at exploring the adverse events following immunization (AEFI) and their incidences among health workers in…
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PLOS ONE Tracheostomy in COVID-19 acute respiratory distress syndrome patients and follow-up: A parisian bicentric retrospective cohort
Background: Tracheostomy has been proposed as an option to help organize the healthcare system to face the unprecedented number of patients…
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PLOS ONE Awareness and preparedness of healthcare workers against the first wave of the COVID-19 pandemic: A cross-sectional survey across 57 countries
Background: Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This…
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PLOS ONE Mortality predictors of hospitalized patients with COVID-19: Retrospective cohort study from Nur-Sultan, Kazakhstan
Background: First reported case of Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in Kazakhstan was identified in…
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PLOS ONE Clinical evaluation of the SD Biosensor SARS-CoV-2 saliva antigen rapid test with symptomatic and asymptomatic, non-hospitalized patients
Background: Performance of the SD Biosensor saliva antigen rapid test was evaluated at a large designated testing site in non-hospitalized…
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PLOS ONE Seroprevalence of antibodies against SARS-Cov-2 in the high impacted sub-district in Jakarta, Indonesia
Background: Understanding the actual prevalence of COVID-19 transmission in the community is vital for strategic responses to the pandemic.…
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PLOS ONE Epidemiological characteristics of COVID-19 travel-associated cases in Vojvodina, Serbia, during 2020
Coronavirus disease 2019 (COVID-19) is currently the biggest public health problem worldwide. Intensive international travel and tourism…
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PLOS ONE Low incidence of COVID-19 in a prospective cohort of patients with liver cirrhosis and hepatocellular carcinoma treated at a tertiary medical center during the 2020 pandemic
Background and aims: Patients with liver cirrhosis (LC) are considered to be at increased risk for mortality when acquiring SARS-CoV-2…
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PLOS ONE Diagnosis of tuberculosis among COVID-19 suspected cases in Ghana
Background: Tuberculosis (TB) and COVID-19 pandemics are both diseases of public health threat globally. Both diseases are caused by…
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PLOS ONE Colchicine use in patients with COVID-19: A systematic review and meta-analysis
Introduction: Colchicine may inhibit inflammasome signaling and reduce proinflammatory cytokines, a purported mechanism of COVID-19…
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PLOS ONE Real-world treatment patterns and clinical outcomes for inpatients with COVID-19 in the US from September 2020 to February 2021
The objective of this retrospective cohort study was to describe pre-treatment characteristics, treatment patterns, health resource use,…
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Image credit161013 Hospitalisation by Randalfino, CC BY 2.0PLOS ONE Determinants of severity among hospitalised COVID-19 patients: Hospital-based case-control study, India, 2020
Background: Risk factors for the development of severe COVID-19 disease and death have been widely reported across several studies.…
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Image creditPhaplu Hospital, Nepal by Peter Dalsgaard, CC BY 2.0PLOS ONE Experiences of COVID-19 patients admitted in a government infectious disease hospital in Nepal and its implications for health system strengthening: A qualitative study
Introduction: The COVID-19 pandemic has affected the health systems in many ways. It has put unprecedented strain on health systems…
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Image creditHospital Bed by Jeff Adair, CC BY 2.0PLOS ONE COVID-19 associated hospitalization in 571 patients with fibromyalgia—A population-based study
Objective: To identify predicators of patients with fibromyalgia (FM) that are associated with a severe COVID-19 disease course. Methods:…
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PLOS ONE COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery
Introduction: Ankle fractures have continued to occur through the COVID pandemic and, regardless of patient COVID status, often need…
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PLOS ONE Incidence of COVID-19 reinfection among Midwestern healthcare employees
Given the overwhelming worldwide rate of infection and the disappointing pace of vaccination, addressing reinfection is critical.…
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PLOS Neglected Tropical Diseases Disease characteristics and serological responses in patients with differing severity of COVID-19 infection: A longitudinal cohort study in Dhaka, Bangladesh
Background: COVID-19 caused by SARS-CoV-2 ranges from asymptomatic to severe disease and can cause fatal and devastating outcome in many…
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PLOS ONE Analytical performances of the AMPLIQUICK® Respiratory Triplex assay for simultaneous detection and differentiation of SARS-CoV-2, influenza A/B and respiratory syncytial viruses in respiratory specimens
Although patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A, influenza B and respiratory…
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PLOS ONE Clotting events among hospitalized patients infected with COVID-19 in a large multisite cohort in the United States
Introduction: COVID-19 infection has been hypothesized to precipitate venous and arterial clotting events more frequently than other…
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PLOS ONE Baseline clinical features of COVID-19 patients, delay of hospital admission and clinical outcome: A complex relationship
Introduction: Delay between symptom onset and access to care is essential to prevent clinical worsening for different infectious diseases.…
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PLOS ONE Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease
Aims: Patients with cardiovascular comorbidities have a significantly increased risk for a critical course of COVID-19. As the SARS-CoV2…
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PLOS ONE Evaluation of clinical outcomes of patients with mild symptoms of coronavirus disease 2019 (COVID-19) discharged from the emergency department
Introduction: This study was performed to determine the clinical outcomes of patients with mild symptoms of COVID-19 discharged from the…
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PLOS ONE Clinical characteristics and viral load dynamics of COVID-19 in a mildly or moderately symptomatic outpatient sample
Background: Studies of outpatients with mild or moderate COVID-19 are uncommon. We studied: 1) association of symptoms with reverse…
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PLOS ONE SARS-CoV-2 infection and cardiovascular or pulmonary complications in ambulatory care: A risk assessment based on routine data
Background: Risk factors of severe COVID-19 have mainly been investigated in the hospital setting. We investigated pre-defined risk factors…
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PLOS ONE Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis
Objective: The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes,…
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PLOS ONE Mortality in association with antipsychotic medication use and clinical outcomes among geriatric psychiatry outpatients with COVID-19
Objectives: Older adults are particularly vulnerable to the negative consequences of antipsychotic exposure and are disproportionally…
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PLOS ONE High association of COVID-19 severity with poor gut health score in Lebanese patients
Background: Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme…
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PLOS ONE Characteristics and outcome of critically ill patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to a tertiary care center in the United Arab Emirates during the first wave of the SARS-CoV-2 pandemic. A retrospective analysis
Background: The aim of this study was to describe the clinical characteristics and outcome of patients with coronavirus disease-2019…
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PLOS Pathogens Induction of trained immunity by influenza vaccination – impact on COVID-19
Non-specific protective effects of certain vaccines have been reported, and long-term boosting of innate immunity, termed trained…
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PLOS ONE Early administration of remdesivir to COVID-19 patients associates with higher recovery rate and lower need for ICU admission: A retrospective cohort study
Objectives: Remdesivir is one of the most widely recommended and used medications for COVID-19 treatment. However, different outcomes have…
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PLOS ONE Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort
The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different…
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PLOS ONE Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study
Effective, low-cost therapeutics are needed to prevent and treat COVID-19. Severe COVID-19 disease is linked to excessive inflammation.…
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PLOS ONE Impact of persistent D-dimer elevation following recovery from COVID-19
Background: Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic…
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PLOS ONE Heart-rate-variability (HRV), predicts outcomes in COVID-19
Background: Patients with COVID-19 present with a variety of clinical manifestations, ranging from mild or asymptomatic disease to severe…
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PLOS ONE Impact of Covid-19 on health-related quality of life of patients: A structured review
Introduction: Coronavirus disease (Covid-19) has led to a global pandemic since its emergence in December 2019. The majority of research…
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PLOS ONE Self-medication practices to prevent or manage COVID-19: A systematic review
Background: Previous studies have assessed the prevalence and characteristics of self-medication in COVID-19. However, no systematic review…
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PLOS ONE Neoadjuvant chemotherapy with dose dense MVAC is associated with improved survival after radical cystectomy compared to other cytotoxic regimens: A tertiary center experience
Introduction: Neoadjuvant chemotherapy has become standard of care for cisplatin-eligible patients with muscle-invasive bladder cancer…
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PLOS ONE Effect of famotidine on hospitalized patients with COVID-19: A systematic review and meta-analysis
Introduction: Famotidine is a competitive histamine H2-receptor antagonist most commonly used for gastric acid suppression but thought to…
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PLOS ONE Mortality and evolution between community and hospital-acquired COVID-AKI
Background: Acute kidney injury (AKI) is associated with poor outcomes in COVID patients. Differences between hospital-acquired (HA-AKI)…
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PLOS ONE Is the BNT162b2 COVID-19 vaccine effective in elderly populations? Results from population data from Bavaria, Germany
Background: The efficacy of the BioNTech-Pfizer BNT162b2 vaccination in the elderly (≥80 years) could not be fully assessed in the…
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PLOS ONE Factors influencing nurses’ behavioral intention toward caring for COVID-19 patients on mechanical ventilation: A cross-sectional study
Objectives: To investigate nurses’ behavioral intention toward caring for COVID-19 patients on mechanical ventilation, as well as the…
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PLOS ONE Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures
Protecting healthcare professionals is crucial in maintaining a functioning healthcare system. The risk of infection and optimal…
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PLOS ONE Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020
Background: The transmission dynamics of SARS-CoV-2 varies depending on social distancing measures, circulating SARS-CoV-2 variants, host…
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PLOS ONE Humoral responses to SARS-CoV-2 mRNA vaccines: Role of past infection
Two mRNA vaccines (BNT162b2 and mRNA-1273) against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) are globally authorized as…
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PLOS ONE Olfactory recovery following infection with COVID-19: A systematic review
Olfactory loss has been identified as one of the common symptoms related to COVID-19 infection. Although olfactory loss is recognized, our…
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PLOS ONE A mixed-methods systematic review of post-viral fatigue interventions: Are there lessons for long Covid?
Objectives: Fatigue syndromes have been widely observed following post-viral infection and are being recognised because of Covid19.…
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PLOS ONE Characteristics and outcome profile of hospitalized African patients with COVID-19: The Ethiopian context
Background: The COVID-19 pandemic seems to have a different picture in Africa; the first case was identified in the continent after it had…
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PLOS ONE Exploring the awareness, attitudes, and actions (AAA) of UK adults at high risk of severe illness from COVID-19
Background: People at high risk of severe illness from COVID-19 have experienced greater restrictions during the pandemic, yet there is a…
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PLOS ONE Evaluation of the SARS-CoV-2 positivity ratio and upper respiratory tract viral load among asymptomatic individuals screened before hospitalization or surgery in Flanders, Belgium
Introduction: The incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in the Belgian community is mainly…
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PLOS ONE Atypical lymphocytes in the peripheral blood of COVID-19 patients: A prognostic factor for the clinical course of COVID-19
Background: Clinical observations have shown that there is a relationship between coronavirus disease 2019 (COVID-19) and atypical…
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PLOS ONE Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study
Background: Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the…
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Image credittake your victories where you can by susan myrland, CC BY 2.0PLOS ONE A qualitative assessment of factors affecting nursing home caregiving staff experiences during the COVID-19 pandemic
Background: A large portion of COVID-19 cases and deaths in the United States have occurred in nursing homes; however, current literature…
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PLOS ONE COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women
Objective: To compare hospitalized reproductive age women with COVID-19 who were pregnant, puerperal, or neither one nor the other in terms…
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PLOS Neglected Tropical Diseases COVID-19–associated mucormycosis: Evidence-based critical review of an emerging infection burden during the pandemic’s second wave in India
Coronavirus Disease 2019 (COVID-19), during the second wave in early 2021, has caused devastating chaos in India. As daily infection rates…
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PLOS ONE The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation
Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes, most of them retrospectively and with…
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PLOS ONE COVID-19 preventive practices during intrapartum care- adherence and barriers in Ethiopia; a multicenter cross- sectional study
Background: Coronavirus disease 19 (COVID-19) is a newly emerging pandemic affecting more than 120 million people globally. Compliance with…
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PLOS ONE Immunosuppression and COVID-19 infection in British Columbia: Protocol for a linkage study of population-based administrative and self-reported survey data
Introduction: Cases of the novel coronavirus disease (COVID-19) continue to spread around the world even one year after the declaration of…
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PLOS ONE Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
Introduction: Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables,…
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PLOS ONE The burden of SARS-CoV-2 among healthcare workers across 16 hospitals of Kashmir, India—A seroepidemiological study
SARS-CoV-2 pandemic has greatly affected healthcare workers because of the high risk of getting infected. The present cross-sectional…
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PLOS ONE Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture
Last year observed a global pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) infection affecting millions…
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PLOS ONE Physical restraint of dementia patients in acute care hospitals during the COVID-19 pandemic: A cohort analysis in Japan
Introduction: The coronavirus disease (COVID-19) pandemic has caused unprecedented challenges for the medical staff worldwide, especially…
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PLOS ONE Drivers and social implications of Artificial Intelligence adoption in healthcare during the COVID-19 pandemic
The COVID-19 pandemic continues to impact people worldwide–steadily depleting scarce resources in healthcare. Medical Artificial…
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PLOS ONE Changes to telehealth practices in primary care in New Brunswick (Canada): A comparative study pre and during the COVID-19 pandemic
Background: During the COVID-19 pandemic, telehealth technologies were used in the primary health care setting in New Brunswick as a means…
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Image creditBlood pressure monitoring by rawpixel.com, CC 0PLOS ONE Knowledge of and preparedness for COVID-19 among Somali healthcare professionals: A cross-sectional study
Background: Somalia is considered severely underprepared to contain an outbreak of COVID-19, with critical shortages in healthcare…
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PLOS ONE COVID-19 pandemic and health worker stress: The mediating effect of emotional regulation
Background/Introduction: Psychological and physical well-being of health personnel has been significantly affected by COVID-19. Work…
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Image creditCOVID-19 testing training by SC National Guard, CC BY 2.0
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PLOS ONE Association between voriconazole exposure and Sequential Organ Failure Assessment (SOFA) score in critically ill patients
Therapeutic drug monitoring (TDM) is essential for voriconazole to ensure optimal drug exposure, mainly in critically ill patients for…
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Image credit2017_04_29_AMISOM constructs sanitation facility for community near AMISOM base-6 by AMISOM Public Information, CC 0PLOS ONE Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients isolated in a community facility
Introduction: Mildly symptomatic cases of Covid-19 in previously-well individuals form the majority of infections and also serve as potent…
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PLOS ONE Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium
Drug repurposing has the potential to bring existing de-risked drugs for effective intervention in an ongoing pandemic—COVID-19 that has…
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PLOS Medicine Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19
Background: Long-COVID refers to a variety of symptoms affecting different organs reported by people following Coronavirus Disease 2019…
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Image credit6VSB spike protein SARS-CoV-2 homotrimer by 5-HT2AR, CC BY 0PLOS ONE Risk for SARS-CoV-2 infection in healthcare workers outside hospitals: A real-life immuno-virological study during the first wave of the COVID-19 epidemic
Objectives: Most COVID-19 related infections and deaths may occur in healthcare outside hospitals. Here we explored SARS-CoV-2 infections…
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PLOS ONE Hydroxychloroquine for the treatment of severe respiratory infection by COVID-19: A randomized controlled trial
Introduction: The novel coronavirus pandemic (COVID–19) represents a major public health problem and it is key to find a treatment that…
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PLOS ONE Risk factors, predictions, and progression of acute kidney injury in hospitalized COVID-19 patients: An observational retrospective cohort study
Objectives: Studies have shown that acute kidney injury (AKI) occurrence post SARS-CoV-2 infection is complex and has a poor prognosis.…
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PLOS ONE A scoping review of patient engagement activities during COVID-19: More consultation, less partnership
Background: The COVID-19 pandemic has had a devastating impact on healthcare systems and care delivery, changing the context for patient…
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PLOS ONE Telehealth at scale can improve chronic disease management in the community during a pandemic: An experience at the time of COVID-19
Background: During the COVID-19 pandemic, telehealth became a vital resource to contain the virus’s spread and ensure continuity of care of…
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PLOS ONE Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis
Background: Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects of the…
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PLOS ONE Geographical variation in demand, utilization, and outcomes of hospital services for COVID-19 in Brazil: A descriptive serial cross-sectional study
Objective: To analyze the geographical variation in the provision of health services, namely in demand, patterns of utilization, and…
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PLOS ONE Prevalence and risk factors for SARS-CoV-2 infection and seroprevalence among clinical and non-clinical staff in a national healthcare system
Background: While many studies have reported the rate and risk of SARS-CoV-2 infection among healthcare workers (HCWs), there are scant…
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PLOS ONE Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is not detected in the vagina: A prospective study
Objective: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is present in the vagina of women diagnosed…
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PLOS ONE Aerosol SARS-CoV-2 in hospitals and long-term care homes during the COVID-19 pandemic
Background: Few studies have quantified aerosol concentrations of SARS-CoV-2 in hospitals and long-term care homes, and fewer still have…
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PLOS ONE Implementation of vascular surgery teleconsultation during the COVID-19 pandemic: Insights from the outpatient vascular clinics in a tertiary care hospital in Qatar
Background: The COVID-19 pandemic has sparked a surge in the use of virtual communication tools for delivering clinical services for many…
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PLOS ONE The impact of COVID-19 pandemic on AMI and stroke mortality in Lombardy: Evidence from the epicenter of the pandemic
Background: The first Covid-19 epidemic outbreak has enormously impacted the delivery of clinical healthcare and hospital management…
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PLOS ONE Effect of a hospital-wide campaign on COVID-19 vaccination uptake among healthcare workers in the context of raised concerns for life-threatening side effects
Background: All healthcare workers (HCWs) in Yongin Severance Hospital were allocated to receive the ChAdOx1 nCov-19 vaccine according to…
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PLOS ONE COVID-19-related outcomes in immunocompromised patients: A nationwide study in Korea
Background: Given the rapid increased in confirmed coronavirus disease 2019 (COVID-19) and related mortality, it is important to identify…
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Image creditHepatitis B and hand hold syringe by Marco Verch, CC BY 2.0PLOS ONE Association between chronic hepatitis B infection and COVID-19 outcomes: A Korean nationwide cohort study
Background/Aims: We measured the association between underlying chronic hepatitis B (CHB) and antiviral use with infection rates among…
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PLOS ONE Altered mental status is a predictor of poor outcomes in COVID-19 patients: A cohort study
Introduction: Several studies have described typical clinical manifestations, including fever, cough, diarrhea, and fatigue with COVID-19…
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Image creditHealthcare worker donning the final article of personal protective equipment (PPE), a plastic apron, which would complete his protective uniform by Centers for Disease Control and Prevention, CC 0PLOS ONE Assessment of knowledge, attitude and practice toward COVID-19 and associated factors among health care workers in Silte Zone, Southern Ethiopia
Introduction: COVID-19 is a pandemic respiratory disease caused by the highly contagious novel coronavirus (SARS-CoV 2). The disease is now…
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Image creditSymptoms of coronavirus disease 2019 (cropped) by Mikael Häggström, M.D., CC 0PLOS ONE Severe COVID-19 in inflammatory bowel disease patients in a population-based setting
Objective: Data on the course of severe COVID-19 in inflammatory bowel disease (IBD) patients remains limited. We aimed to determine the…
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PLOS ONE COVID-19 in lung transplant recipients—Risk prediction and outcomes
Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in…
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PLOS ONE Comprehensive evaluation of COVID-19 patient short- and long-term outcomes: Disparities in healthcare utilization and post-hospitalization outcomes
Background: Understanding risk factors for short- and long-term COVID-19 outcomes have implications for current guidelines and practice. We…
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PLOS ONE Disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic in March–October 2020: An exploratory analysis
We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested…
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PLOS ONE Reduced turnaround times through multi-sectoral community collaboration during the first surge of SARS-CoV-2 and associated effect on patient care and hospital operations
Background: In March 2020, an influx of admissions in COVID-19 positive patients threatened to overwhelm healthcare facilities in East…
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PLOS ONE Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study
Background: Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe…
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PLOS ONE Disparities in telemedicine utilization among surgical patients during COVID-19
Background: Telemedicine has been rapidly adopted in the wake of the COVID-19 pandemic. There is limited work surrounding demographic and…
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PLOS ONE Impacts of mild COVID-19 on elevated use of primary and specialist health care services: A nationwide register study from Norway
Aim: To explore the temporal impact of mild COVID-19 on need for primary and specialist health care services. Methods: In all adults (≥20…
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PLOS ONE Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study
This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north,…
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PLOS ONE Comprehensive infection control measures prevent hospital-acquired severe acute respiratory syndrome coronavirus 2 infection: A single-center prospective cohort study and seroprevalence survey
Background: Coronavirus disease (COVID-19) is associated with a high mortality rate in older adults; therefore, it is important for medical…
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PLOS ONE Increased risk of hospitalisation and intensive care admission associated with reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December 2020 –May 2021
Introduction: Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk…
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PLOS Medicine Transmission of community- and hospital-acquired SARS-CoV-2 in hospital settings in the UK: A cohort study
Background: Nosocomial spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been widely reported, but the…
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Image creditChicago Lakeshore View Aerial by Carol M Highsmith, CC 0PLOS ONE COVID-19 health inequities and association with mechanical ventilation and prolonged length of stay at an urban safety-net health system in Chicago
Millions of Americans have been infected with COVID-19 and communities of color have been disproportionately burdened. We investigated the…
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PLOS ONE Patient attendance at a pediatric emergency referral hospital in an area with low COVID-19 incidence
The purpose of this study was to clarify the effects of individual infection control measures and physical distancing on pediatric medical…
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PLOS ONE J-waves in acute COVID-19: A novel disease characteristic and predictor of mortality?
Background: J-waves represent a common finding in routine ECGs (5–6%) and are closely linked to ventricular tachycardias. While arrhythmias…
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PLOS ONE Clinical and epidemiological characteristics of patients seeking COVID-19 testing in a private centre in Malaysia: Is there a role for private healthcare in battling the outbreak?
Objective: This cross-sectional observational study summarized the baseline characteristics of subjects who underwent COVID-19 molecular…
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PLOS Medicine HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study
Background: The relationship between statin treatment and Coronavirus Disease 2019 (COVID-19) mortality has been discussed due to the…
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PLOS ONE Association of abnormal pulmonary vasculature on CT scan for COVID-19 infection with decreased diffusion capacity in follow up: A retrospective cohort study
Background: Coronavirus Disease 2019 (COVID-19) is a respiratory viral illness causing pneumonia and systemic disease. Abnormalities in…
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Image credit6VSB spike protein SARS-CoV-2 monomer by 5-HT2AR, CC 0PLOS ONE Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers
Background and objective: The risk factors for breakthrough infections among healthcare workers (HCW) after completion of a full course of…
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PLOS ONE Feasibility of CPAP application and variables related to worsening of respiratory failure in pregnant women with SARS-CoV-2 pneumonia: Experience of a tertiary care centre
Continuous positive airway pressure (CPAP) has been successfully applied to patients with COVID-19 to prevent endotracheal intubation.…
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PLOS ONE Understanding an evolving pandemic: An analysis of the clinical time delay distributions of COVID-19 in the United Kingdom
Understanding and monitoring the epidemiological time delay dynamics of SARS-CoV-2 infection provides insights that are key to discerning…
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PLOS ONE Altered smell and taste: Anosmia, parosmia and the impact of long Covid-19
Background: Qualitative olfactory (smell) dysfunctions are a common side effect of post-viral illness and known to impact quality of life…
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PLOS ONE Predictors of severity and development of critical illness of Egyptian COVID-19 patients: A multicenter study
Objectives: We conducted the present multicenter, retrospective study to assess the epidemiological, clinical, laboratory, and radiological…
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PLOS ONE Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence: Navigating the absence of a gold standard
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence studies bridge the gap left from case detection, to…
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PLOS ONE SARS-CoV-2 pneumonia follow-up and long COVID in primary care: A retrospective observational study in Madrid city
Background: Patients with COVID-19 are follow-up in primary care and long COVID is scarcely defined. The study aim was to describe…
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PLOS ONE Use of medicinal plants for COVID-19 prevention and respiratory symptom treatment during the pandemic in Cusco, Peru: A cross-sectional survey
Background: The burden of the COVID-19 pandemic in Peru has led to people seeking alternative treatments as preventives and treatment…
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PLOS ONE A national survey of hospital readiness during the COVID-19 pandemic in Nigeria
Introduction: The COVID-19 pandemic continues to overwhelm health systems across the globe. We aimed to assess the readiness of hospitals…
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PLOS ONE Immunological assessment of SARS-CoV-2 infection in pregnancy from diagnosis to delivery: A multicentre prospective study
Background: Background Population-based data on SARS-CoV-2 infection in pregnancy and assessment of passive immunity to the neonate, is…
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Image creditFig 1. The Sani nudge hygiene system in a hospital patient room by Hüttel et al., CC BY 4.0PLOS ONE Analysis of social interactions and risk factors relevant to the spread of infectious diseases at hospitals and nursing homes
Ensuring the safety of healthcare workers is vital to overcome the ongoing COVID-19 pandemic. We here present an analysis of the social…
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PLOS ONE Cancer care disruption and reorganisation during the COVID-19 pandemic in Australia: A patient, carer and healthcare worker perspective
The COVID-19 pandemic has dramatically impacted cancer care worldwide. Disruptions have been seen across all facets of care. While the…
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Image creditHome Heart Rate Monitor - Finger Pulse Checker and a Stethoscope by www.doctor-4-u.co.uk, CC BY 2.0PLOS ONE Study protocol of the PEruvian Registry of ST-segment Elevation Myocardial Infarction II (PERSTEMI-II) study
Background: Myocardial infarction (MI) is the most prevalent cardiovascular disease globally and is considered a public health problem. In…
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PLOS ONE Performance of COVID-19 associated symptoms and temperature checking as a screening tool for SARS-CoV-2 infection
Introduction: Coronavirus disease-19 (COVID-19), which started in late December, 2019, has spread to affect 216 countries and territories…
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PLOS ONE Blood cancer care in a resource limited setting during the Covid-19 outbreak; a single center experience from Sri Lanka
Background: The Covid-19 pandemic has caused significant morbidity and mortality among patients with cancer. Most countries employed…
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Image creditInauguración del Hospital Municipal de Chiconcuac by Presidencia de la Repúblic, CC BY 2.0PLOS ONE The potential impact of triage protocols on racial disparities in clinical outcomes among COVID-positive patients in a large academic healthcare system
Background: The COVID-19 pandemic has had a devastating impact in the United States, particularly for Black populations, and has heavily…
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PLOS Pathogens Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth…
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PLOS ONE Influence of coronavirus disease 2019 on myopic progression in children treated with low-concentration atropine
Purpose: The outbreak of coronavirus disease 2019 (COVID-19) has caused many children to stay indoors. Increased near work and insufficient…
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PLOS ONE Lack of effect on in-hospital mortality of drugs used during COVID-19 pandemic: Findings of the retrospective multicenter COVOCA study
Introduction: During COVID-19 pandemic, the use of several drugs has represented the worldwide clinical practice. However, though the…
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Image creditA doctor holding a magnifying glass. by Nenad Stojkovic, CC BY 2.0PLOS ONE Examining and investigating the impact of demographic characteristics and chronic diseases on mortality of COVID-19: Retrospective study
Background: Epidemiological features characterization of COVID-19 is highly important for developing and implementing effective control…
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Image creditStethoscope and heartbeats on red by Marco Verch, CC BY 2.0PLOS ONE Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study
It has been widely observed that adult men of all ages are at higher risk of developing serious complications from COVID-19 when compared…
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Image creditFig 2. Gross pathology of macroscopic hemorrhages by Santana et al., CC BY 4.0PLOS ONE Hemorrhagic and thrombotic manifestations in the central nervous system in COVID-19: A large observational study in the Brazilian Amazon with a complete autopsy series
SARS-CoV-2 affects mainly the lungs, however, other manifestations, including neurological manifestations, have also been described during…
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Image creditDoctor explains cardiogram data, consultation by Marco Verch, CC BY 2.0PLOS ONE Real-life use of tocilizumab with or without corticosteroid in hospitalized patients with moderate-to-severe COVID-19 pneumonia: A retrospective cohort study
Objective: To evaluate the effectiveness of Tocilizumab (with or without corticosteroids) in a real-life context among moderate-to-severe…
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Image creditFig 1. Emergency departments in the Netherlands (June 2020) by O’Connor et al., CC BY 4.0PLOS ONE Preparations of Dutch emergency departments for the COVID-19 pandemic: A questionnaire-based study
Background: The onset of the COVID-19 pandemic was characterized by rapid increases in Emergency department (ED) patient visits. EDs…
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Image creditMedical consultation by sergio santos, CC BY 2.0PLOS ONE Enabling teleophthalmology during the COVID-19 pandemic in the Province of Trento, Italy: Design and implementation of a mHealth solution
Background: Due to the many restrictions imposed during the COVID-19 emergency, the normal clinical activities have been stopped abruptly…
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Image creditWorking place of a coronavirus vaccination center worker by Marco Verch, CC BY 2.0PLOS ONE Statins use and COVID-19 outcomes in hospitalized patients
Background: There is an urgent need for novel therapeutic strategies for reversing COVID-19-related lung inflammation. Recent evidence has…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain 1.0PLOS ONE Elevated C-reactive protein in early COVID-19 predicts worse survival among hospitalized geriatric patients
Background: The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality…
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Image creditGloves and disposable medical mask on a white background by Marco Verch, CC BY 2.0PLOS ONE Health knowledge, health behaviors and attitudes during pandemic emergencies: A systematic review
Background: People with good health knowledge present a conceptual and objective appropriation of general and specific health topics,…
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Image creditDoctor chest with stethoscope in pocket by www.authoritydental.org., CC BY 2.0PLOS ONE Nurses’ perspectives of taking care of patients with Coronavirus disease 2019: A phenomenological study
The pandemic of Coronavirus disease 2019 (COVID-19) has brought significant pressure on nurses globally as they are the frontline of care.…
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PLOS ONE Risk factors for hospitalization among persons with COVID-19—Colorado
Background: Most current evidence on risk factors for hospitalization because of coronavirus disease 2019 (COVID-19) comes from studies…
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PLOS ONE Pulmonary function and six-minute-walk test in patients after recovery from COVID-19: A prospective cohort study
Objectives: To study abnormality of spirometry, six-minute walk distance, and chest radiograph among patients recovered from Coronavirus…
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PLOS ONE Physiological respiratory parameters in pre-hospital patients with suspected COVID-19: A prospective cohort study
Background: The COVID-19 pandemic has presented emergency medical services (EMS) worldwide with the difficult task of identifying patients…
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PLOS ONE Possibility of deterioration of respiratory status when steroids precede antiviral drugs in patients with COVID-19 pneumonia: A retrospective study
Introduction: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Although most patients with…
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PLOS ONE Impacts of COVID-19 on essential health services in Tigray, Northern Ethiopia: A pre-post study
Background: COVID-19 has proved to have an indirect impact on essential health services in several parts of the world which could lead to…
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Image creditFig 2. Assessment of methodological quality by Du et al., CC BY 4.0PLOS ONE Add-on effect of Chinese herbal medicine in the treatment of mild to moderate COVID-19: A systematic review and meta-analysis
Introduction: Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic since its outbreak in Wuhan, China. It is an urgent task…
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Image creditWorking place of a coronavirus vaccination center worker by Marco Verch, CC BY 2.0PLOS ONE COVID-19 pandemic: Impact on the management of patients with hepatocellular carcinoma at a tertiary care hospital
Background: Patients with hepatocellular carcinoma (HCC) represent a vulnerable population potentially negatively affected by…
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PLOS ONE D-dimer as a biomarker for assessment of COVID-19 prognosis: D-dimer levels on admission and its role in predicting disease outcome in hospitalized patients with COVID-19
Introduction: Coronavirus Disease 2019 is a primarily respiratory illness that can cause thrombotic disorders. Elevation of D-dimer is a…
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PLOS ONE Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients
Coronavirus disease (COVID)-19, as a result of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has been the direct…
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PLOS ONE Persisting symptoms three to eight months after non-hospitalized COVID-19, a prospective cohort study
Long-COVID-19 is a proposed syndrome negatively affecting the health of COVID-19 patients. We present data on self-rated health three to…
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Image creditWorking place of a coronavirus vaccination center worker by Marco Verch, CC BY 2.0PLOS ONE Health emergencies and interoceptive sensibility modulate the perception of non-evidence-based drug use: Findings from the COVID-19 outbreak
Scientific evidence plays an important role in the therapeutic decision-making process. What happens when physicians are forced to make…
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PLOS ONE Don’t close the book on tocilizumab for the treatment of severe COVID-19 pneumonia–the jury is still out: The Kuwait experience
Purpose: This cross-sectional observational study aims to report preliminary data from the first experience using tocilizumab for patients…
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Image creditFig 1. VA distribution of the patients by Li et al., CC BY 4.0PLOS ONE The impact of the COVID-19 pandemic lockdown on rhegmatogenous retinal detachment services—Experiences from the Tongren eye center in Beijing
Purpose: To investigate the impact on services for rhegmatogenous retinal detachment (RRD) patients during the COVID-19 (2019coronal virus…
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PLOS ONE COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab
Background: Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and…
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PLOS ONE The impact of the Covid-19 pandemic on quality of life in skin cancer patients
With more than 82 million cases worldwide and almost two million deaths, the Covid-19 global pandemic shows little sign of abating.…
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PLOS ONE The impact of the COVID-19 pandemic on microbial keratitis presentation patterns
Background: Microbial keratitis (MK) is the most common non-surgical ophthalmic emergency, and can rapidly progress, causing irreversible…
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Image creditFig 1. Relative importance of predictors of cardiovascular involvement by Beck-Friis et al., CC BY 4.0PLOS ONE No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did not
Background: Chloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of…
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Image creditMedical consultation by nursingschoolsnearme.com, CC BY 2.0PLOS ONE Obesity is independently associated with septic shock, renal complications, and mortality in a multiracial patient cohort hospitalized with COVID-19
Background: Obesity has emerged as a risk factor for severe coronavirus disease 2019 (COVID-19) infection. To inform treatment…
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PLOS ONE Efficacy of a four-tier infection response system in the emergency department during the coronavirus disease-2019 outbreak
Introduction: The coronavirus disease (COVID-19) pandemic has delayed the management of other serious medical conditions. This study…
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Image creditDoctor chest with stethoscope in pocket by Authority Dental, CC BY 2.0PLOS ONE Serological prevalence of SARS-CoV-2 infection and associated factors in healthcare workers in a “non-COVID” hospital in Mexico City
Background: Mexico is one of the countries with the highest number of deaths from the COVID-19 pandemic. In spite of this high mortality,…
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PLOS ONE Evaluation of the epidemiological behavior of mortality due to COVID-19 in Brazil: A time series study
The World Health Organization declared, at the end of 2019, a pandemic caused by SARS-CoV-2, a virus that causes Coronavirus…
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Image creditStethoscope, pills, and syringe on white table by Authority Dental, CC BY 2.0PLOS ONE Changes in the top 25 reasons for primary care visits during the COVID-19 pandemic in a high-COVID region of Canada
Purpose: We aimed to determine the degree to which reasons for primary care visits changed during the COVID-19 pandemic. Methods: We used…
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PLOS ONE Combining IL-6 and SARS-CoV-2 RNAaemia-based risk stratification for fatal outcomes of COVID-19
Background: The coronavirus disease 2019 (COVID-19) pandemic rapidly increases the use of mechanical ventilation (MV). Such cases further…
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Image creditFig 1. Description of the cohort by Shoaib et al., CC BY 4.0PLOS ONE COVID-19 severity: Studying the clinical and demographic risk factors for adverse outcomes
Background: The primary goal of the presented cross-sectional observational study was to determine the clinical and demographic risk…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE COVID-19 and cause of pregnancy loss during the pandemic: A systematic review
Introduction: The association between Coronavirus Disease 2019 (COVID-19) and abortion has been debated since the beginning of the COVID-19…
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Image creditIntravenous therapy (IV) drip by Robert Geiger, CC BY 2.0PLOS ONE The tumor patient in the COVID-19 pandemic–an interview-based study of 30 patients undergoing systemic antiproliferative therapy
Introduction: Five months after COVID-19 first occurred and protective regulations were introduced, patients at three outpatient…
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PLOS ONE Characteristics and outcomes of acute kidney injury in hospitalized COVID-19 patients: A multicenter study by the Turkish society of nephrology
Background: Acute kidney injury (AKI) is common in coronavirus disease-2019 (COVID-19) and the severity of AKI is linked to adverse…
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PLOS Pathogens Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model
Impaired type I interferons (IFNs) production or signaling have been associated with severe COVID-19, further promoting the evaluation of…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS Biology Challenges in interpreting cytokine data in COVID-19 affect patient care and management
Challenges in using cytokine data are limiting Coronavirus Disease 2019 (COVID-19) patient management and comparison among different…
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PLOS ONE A new haematocytometric index: Predicting severity and mortality risk value in COVID-19 patients
Introduction: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 virus, is a major public health concern spanning from healthy…
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PLOS ONE 6-month mortality and readmissions of hospitalized COVID-19 patients: A nationwide cohort study of 8,679 patients in Germany
Background: COVID-19 frequently necessitates in-patient treatment and in-patient mortality is high. Less is known about the long-term…
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PLOS ONE Preterm birth is not associated with asymptomatic/mild SARS-CoV-2 infection per se: Pre-pregnancy state is what matters
Evidence for the real impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is unclear, as…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS ONE Anxious temperament and cyberchondria as mediated by fear of COVID-19 infection: A cross-sectional study
This study’s main goal was to evaluate the association between anxious temperament and the fear of COVID-19-related self-infection and…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS Neglected Tropical Diseases Use of minimally invasive autopsy during the COVID-19 pandemic and its possibilities in the context of developing countries
…
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Image creditNew Monitor/New Desk by Dave Fayram, CC BY 2.0PLOS ONE Application of telemedicine in the COVID-19 epidemic: An analysis of Gansu Province in China
This paper analyzes the application of various telemedicine services in Gansu Province, China during the COVID-19 epidemic, and summarizes…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain
Background: Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Examining the potential benefits of the influenza vaccine against SARS-CoV-2: A retrospective cohort analysis of 74,754 patients
Introduction: Recently, several single center studies have suggested a protective effect of the influenza vaccine against severe acute…
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PLOS ONE Reduction in hospitalised COPD exacerbations during COVID-19: A systematic review and meta-analysis
Background: Reports have suggested a reduction in exacerbations of chronic obstructive pulmonary disease (COPD) during the coronavirus…
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PLOS ONE Risk factors for severity of COVID-19 in hospital patients age 18–29 years
Background: Since February 2020, over 2.5 million Texans have been diagnosed with COVID-19, and 20% are young adults at risk for SARS-CoV-2…
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Image creditImage title by agilemktg1, Public Domain Mark 1.0PLOS ONE Trends in COVID-19 cases and clinical management in Veterans Health Administration medical facilities: A national cohort study
Objective: We explored longitudinal trends in sociodemographic characteristics, reported symptoms, laboratory findings, pharmacological and…
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Image creditFig 1. Timeline of the study by Arévalos et al., CC BY 4.0PLOS ONE Long-term effects of coronavirus disease 2019 on the cardiovascular system, CV COVID registry: A structured summary of a study protocol
Background: Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events,…
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PLOS ONE A national retrospective study of the association between serious operational problems and COVID-19 specific intensive care mortality risk
Objectives: To describe the relationship between reported serious operational problems (SOPs), and mortality for patients with COVID-19…
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PLOS ONE Topological network based drug repurposing for coronavirus 2019
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has become the current health concern and…
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PLOS ONE Streamlining brain tumor surgery care during the COVID-19 pandemic: A case-control study
Background: The COVID-19 pandemic forced a reconsideration of surgical patient management in the setting of scarce resources and risk of…
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PLOS Neglected Tropical Diseases The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study
Background: Protective effects of Bacillus Calmette–Guérin (BCG) vaccination and clofazimine and dapsone treatment against severe acute…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS ONE High mortality among kidney transplant recipients diagnosed with coronavirus disease 2019: Results from the Brazilian multicenter cohort study
Background: Kidney transplant (KT) recipients are considered a high-risk group for unfavorable outcomes in the course of coronavirus…
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PLOS ONE Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19
Background: Limited therapeutic options exist for coronavirus disease 2019 (COVID-19). COVID-19 convalescent plasma (CCP) is a potential…
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PLOS ONE Lower serum 25(OH)D levels associated with higher risk of COVID-19 infection in U.S. Black women
Objective: Limited evidence suggests that higher levels of serum vitamin D (25(OH)D) protect against SARS-CoV-2 virus (COVID-19) infection.…
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Image creditFig 4. Cumulative frequency of observed sedation depth by Flinspach et al., CC BY 4.0PLOS ONE High sedation needs of critically ill COVID-19 ARDS patients—A monocentric observational study
Background: Therapy of severely affected coronavirus patient, requiring intubation and sedation is still challenging. Recently,…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, Public Domain Mark 1.0PLOS ONE COVID-19 severity and mortality in multiple sclerosis are not associated with immunotherapy: Insights from a nation-wide Austrian registry
Background: The COVID-19 pandemic challenges neurologists in counselling patients with multiple sclerosis (pwMS) regarding their risk by…
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PLOS ONE Hematological abnormalities and comorbidities are associated with COVID-19 severity among hospitalized patients: Experience from Bangladesh
Background: The hematological abnormalities are assumed to be involved in the disease progression of COVID-19. However, the actual…
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PLOS ONE Facing the COVID-19 pandemic inside maternities in Brazil: A mixed-method study within the REBRACO initiative
Introduction: COVID-19 pandemic posed major challenges in obstetric health care services. Preparedness, development, and implementation of…
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PLOS ONE Rethinking remdesivir for COVID-19: A Bayesian reanalysis of trial findings
Background: Following testing in clinical trials, the use of remdesivir for treatment of COVID-19 has been authorized for use in parts of…
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Image creditFig 1. Experimental model simulating endoscopic examination by Keil et al., CC BY 4.0PLOS ONE Commonly available but highly effective protection against SARS-CoV-2 during gastrointestinal endoscopies
Background and aims: SARS-CoV-2 is a worldwide serious health problem. The aim of this study was to demonstrate the number of potentially…
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Image creditFig 1. Clinical features of the cohort by Meis-Pinheiro et al., CC BY 4.0PLOS ONE Clinical characteristics of COVID-19 in older adults. A retrospective study in long-term nursing homes in Catalonia
The natural history of COVID-19 and predictors of mortality in older adults need to be investigated to inform clinical operations and…
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PLOS ONE Mortality and associated risk factors of COVID-19 infection in dialysis patients in Qatar: A nationwide cohort study
Context: Patients on maintenance dialysis are more susceptible to COVID-19 and its severe form. We studied the mortality and associated…
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PLOS ONE Both high and low pre-infection glucose levels associated with increased risk for severe COVID-19: New insights from a population-based study
Importance: Patients with diabetes are known to be at increased risk for infections including severe coronavirus disease 2019 (COVID-19)…
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Image creditImage title by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS ONE The impact of medical teleconsultations on general practitioner-patient communication during COVID- 19: A case study from Poland
According to the outbreak of the Covid-19 pandemic, medical teleconsultations using various technologies have become an important tool to…
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PLOS ONE Knowledge, attitude and preventive practice towards COVID-19 and associated factors among outpatient service visitors at Debre Markos compressive specialized hospital, north-west Ethiopia, 2020
Background: COVID-19 is an emerging infectious disease which is a major public health problem worldwide. Given the serious threats imposed…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, Public Domain Mark 1.0PLOS ONE Manifestations of renal system involvement in hospitalized patients with COVID-19 in Saudi Arabia
Background: Although COVID-19 is an acute disease that usually resolves rapidly in most cases, the disease can be fatal and has a mortality…
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Image creditImage title by NIAID/NIH, Public Domain Mark 1.0PLOS ONE Relation of prior statin and anti-hypertensive use to severity of disease among patients hospitalized with COVID-19: Findings from the American Heart Association’s COVID-19 Cardiovascular Disease Registry
Background: Statins have anti-inflammatory and immunomodulatory effects that may reduce the severity of coronavirus disease 2019…
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Image creditFig 2. The proportion of municipalities attended by TRS in Brazil by region by Montelongo et al., CC BY 4.0PLOS ONE The management of COVID-19 cases through telemedicine in Brazil
In Dec 2020 Brazil became one of the worldwide epicenters of the COVID-19 pandemic with more than 7.2M reported cases. Brazil has a large…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain 1.0PLOS ONE Pre-hospital causes for delayed arrival in acute ischemic stroke before and during the COVID-19 pandemic: A study at two stroke centers in Egypt
Background: In the current study we investigated the causes of pre-hospital delay as this can compromise the patient’s chance to receive…
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Image creditFig 1. Immune response to SARS-CoV-2 infection model schematic by Jenner et al., CC BY 4.0PLOS Pathogens COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we…
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Image creditbacteria/viruses by John Voo, CC BY 2.0PLOS ONE Bacterial superinfection in adults with COVID-19 hospitalized in two clinics in Medellín-Colombia, 2020
COVID-19 represents high morbidity and mortality, its complications and lethality have increased due to bacterial superinfections. We…
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Image creditFig 2. Outcome of the patients in each group by Miki et al., CC BY 4.0PLOS ONE On-admission SARS-CoV-2 RNAemia as a single potent predictive marker of critical condition development and mortality in COVID-19
Background: This study aimed to clarify how SARS-CoV-2 RNAemia is related to COVID-19 critical condition development and mortality in…
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PLOS ONE Intention to receive vaccine against COVID-19 and associated factors among health professionals working at public hospitals in resource limited settings
Backgrounds: Health professionals are among the frontline of COVID-19 pandemic exposure and identified as a priority target group that need…
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Image creditInauguración del Hospital Municipal de Chiconcuac by Presidencia de la República Mexicana, CC BY 2.0PLOS ONE Burden of post-COVID-19 syndrome and implications for healthcare service planning: A population-based cohort study
Background: Longer-term consequences after SARS-CoV-2 infection are becoming an important burden to societies and healthcare systems. Data…
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Image creditFig 1. Subgroup breakdown for analyses. by Brojakowska et al., CC BY 4.0PLOS ONE Comorbidities, sequelae, blood biomarkers and their associated clinical outcomes in the Mount Sinai Health System COVID-19 patients
With the continuing rise of SARS-CoV2 infection globally and the emergence of various waves in different countries, understanding…
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PLOS ONE The impact of the COVID-19 pandemic on waiting times for elective surgery patients: A multicenter study
Background: A concern has been that health care reorganizations during the first COVID-19 wave have led to delays in elective surgeries,…
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PLOS ONE Dexamethasone may improve severe COVID-19 via ameliorating endothelial injury and inflammation: A preliminary pilot study
Dexamethasone provides benefits in patients with coronavirus disease 2019 (COVID-19), although data regarding immunological profiles and…
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PLOS ONE Identifying factors that nurses consider in the decision-making process related to patient care during the COVID-19 pandemic
Background: Nurse identification of patient deterioration is critical, particularly during the COVID-19 pandemic, as patients can…
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PLOS ONE Characterization of antibody response in asymptomatic and symptomatic SARS-CoV-2 infection
SARS-CoV-2 pandemic is causing high morbidity and mortality burden worldwide with unprecedented strain on health care systems. To…
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Image creditFig 1. Illustration of the modeling framework. by Mahdavi et al., CC BY 4.0PLOS ONE A machine learning based exploration of COVID-19 mortality risk
Early prediction of patient mortality risks during a pandemic can decrease mortality by assuring efficient resource allocation and…
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PLOS Medicine Sales of antibiotics and hydroxychloroquine in India during the COVID-19 epidemic: An interrupted time series analysis
Background: We assessed the impact of the coronavirus disease 2019 (COVID-19) epidemic in India on the consumption of antibiotics and…
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PLOS ONE High rate of HSV-1 reactivation in invasively ventilated COVID-19 patients: Immunological findings
SARS-CoV-2 infection can lead to severe acute respiratory distress syndrome with the need of invasive ventilation. Pulmonary herpes…
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PLOS ONE How risky is it to visit a supermarket during the pandemic?
We performed large-scale numerical simulations using a composite model to investigate the infection spread in a supermarket during a…
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PLOS ONE A public survey of traditional, complementary and integrative medicine use during the COVID-19 outbreak in Hong Kong
Background: During COVID-19, the public actively sought non-pharmacological and self-management approaches to prevent infection. Little is…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE The impact of the SARS-COV2 infection on the disorder of consciousness rehabilitation unit
Background and objective: Disorders of consciousness include coma (cannot be aroused, eye remain closed), vegetative state—VS (can appear…
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PLOS ONE Evaluating the association between COVID-19 and psychiatric presentations, suicidal ideation in an emergency department
Objective: To estimate the association between COVID-19 and Emergency Department (ED) psychiatric presentations, including suicidal…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis
Objective: To describe the laboratory parameters and biomarkers of the cytokine storm syndrome associated with severe and fatal COVID-19…
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PLOS ONE COVID-19 laboratory preparedness and response in the Americas Region: Lessons learned
By the time the etiologic agent of the COVID-19 was identified as a novel coronavirus, no country in the Americas Region had laboratory…
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PLOS ONE Comparison of three serological chemiluminescence immunoassays for SARS-CoV-2, and clinical significance of antibody index with disease severity
Background: The clinical significance of the quantitative value of antibodies in severe acute respiratory syndrome coronavirus 2…
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PLOS ONE COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes
Background: We conducted an overview of systematic reviews (SRs) summarizing the best evidence regarding the effect of COVID-19 on maternal…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and eosinophils correlation with high-resolution computer tomography severity score in COVID-19 patients
Inflammation has an important role in the progression of various viral pneumonia, including COVID-19. Circulating biomarkers that can…
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Image creditFig 1. Pattern of worry scores of COVID-19 crisis by hospital. by Deressa et al., CC BY 4.0PLOS ONE Risk perceptions and preventive practices of COVID-19 among healthcare professionals in public hospitals in Addis Ababa, Ethiopia
Healthcare professionals are at higher risk of contracting the new coronavirus disease 2019 (COVID-19). Although appropriate preventive…
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PLOS ONE Impact of Covid-19 on attendances for a 1st episode of reduced fetal movements: A retrospective observational study
Background: Prior studies have demonstrated an increased stillbirth rate. It was suggested that the COVID-19 pandemic may have impacted on…
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PLOS ONE Improved outcomes over time for adult COVID-19 patients with acute respiratory distress syndrome or acute respiratory failure
Background: COVID-19’s pulmonary manifestations are broad, ranging from pneumonia with no supplemental oxygen requirements to acute…
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PLOS ONE Estimating ventilation rates in rooms with varying occupancy levels: Relevance for reducing transmission risk of airborne pathogens
Background: In light of the role that airborne transmission plays in the spread of SARS-CoV-2, as well as the ongoing high global mortality…
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Image creditSyringe and Vaccine by NIH/NIAID, CC BY 2.0PLOS ONE Determinant of intention to receive COVID-19 vaccine among school teachers in Gondar City, Northwest Ethiopia
Background: Scientists across the world are working on innovating a successful vaccine that will save lives and end COVID-19 pandemic.…
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Image creditFig 3. Statin use, after hospitalization. by Chow et al., CC BY 4.0PLOS ONE The protective association between statins use and adverse outcomes among COVID-19 patients: A systematic review and meta-analysis
Introduction: Statins may reduce a cytokine storm, which has been hypothesized as a possible mechanism of severe COVID-19 pneumonia. The…
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PLOS Pathogens Dating first cases of COVID-19
Questions persist as to the origin of the COVID-19 pandemic. Evidence is building that its origin as a zoonotic spillover occurred prior…
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PLOS Computational Biology Contrasting factors associated with COVID-19-related ICU admission and death outcomes in hospitalised patients by means of Shapley values
Identification of those at greatest risk of death due to the substantial threat of COVID-19 can benefit from novel approaches to…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE COVID-19 pneumonia in Galicia (Spain): Impact of prognostic factors and therapies on mortality and need for mechanical ventilation
Introduction: This study was aimed to identify risk factors associated with unfavorable outcomes (composite outcome variable: mortality and…
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Image creditFig 2. Map of national seroprevalence studies reporting population-wide estimates. by Natural Earth and Bobrovitz et al., CC BY 4.0PLOS ONE Global seroprevalence of SARS-CoV-2 antibodies: A systematic review and meta-analysis
Background: Many studies report the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. We aimed to…
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PLOS ONE Body mass index and severity/fatality from coronavirus disease 2019: A nationwide epidemiological study in Korea
Objective: Obesity has been reported as a risk factor for severe coronavirus disease 2019 (COVID-19) in recent studies. However, the…
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PLOS ONE Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia
Background: Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal…
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Image creditFig 1. Logistic growth curve of the COVID-19 pandemic. by Kaimann and Tanneberg, CC BY 4.0PLOS ONE What containment strategy leads us through the pandemic crisis? An empirical analysis of the measures against the COVID-19 pandemic
Since January 2020, the COVID-19 outbreak has been progressing at a rapid pace. To keep the pandemic at bay, countries have implemented…
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PLOS ONE Predictors of severity and mortality among patients hospitalized with COVID-19 in Rhode Island
Background: In order for healthcare systems to prepare for future waves of COVID-19, an in-depth understanding of clinical predictors is…
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PLOS ONE An in vitro study of dual drug combinations of anti-viral agents, antibiotics, and/or hydroxychloroquine against the SARS-CoV-2 virus isolated from hospitalized patients in Surabaya, Indonesia
A potent therapy for the infectious coronavirus disease COVID-19 is urgently required with, at the time of writing, research in this area…
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PLOS ONE Association of the past epidemic of Mycobacterium tuberculosis with mortality and incidence of COVID-19
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created…
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Image creditFig 1. Culminating measures model for the general population. by Shumway et al., CC BY 4.0PLOS ONE Predictors of compliance with COVID-19 related non-pharmaceutical interventions among university students in the United States
The world is currently dealing with a devastating pandemic. Although growing COVID-19 case numbers, deaths, and hospitalizations are…
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PLOS ONE COVID-19 in persons aged 70+ in an early affected German district: Risk factors, mortality and post-COVID care needs—A retrospective observational study of hospitalized and non-hospitalized patients
Background: Cohorts of hospitalized COVID-19 patients have been studied in several countries since the beginning of the pandemic. So far,…
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PLOS Computational Biology Estimating the cumulative incidence of COVID-19 in the United States using influenza surveillance, virologic testing, and mortality data: Four complementary approaches
Effectively designing and evaluating public health responses to the ongoing COVID-19 pandemic requires accurate estimation of the…
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Image creditFig 1. Pathogen reproductive number, Rt, plotted against the ratio of contacts needing tracing to contact tracing capacity for variable delays (1/τIs) of 1–5 and 10 days between case symptom onset and the start of contact tracing (including getting tested and receiving result). by Gardner and Kilpatrick, CC BY 4.0PLOS Computational Biology Contact tracing efficiency, transmission heterogeneity, and accelerating COVID-19 epidemics
Simultaneously controlling COVID-19 epidemics and limiting economic and societal impacts presents a difficult challenge, especially with…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE Post-infectious and post-acute sequelae of critically ill adults with COVID-19
Background: Data on the post-acute and post-infectious complications of patients who have recovered from severe coronavirus disease 2019…
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PLOS ONE Predictors of incident viral symptoms ascertained in the era of COVID-19
Background: In the absence of universal testing, effective therapies, or vaccines, identifying risk factors for viral infection,…
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PLOS ONE Feasibility of collecting and processing of COVID-19 convalescent plasma for treatment of COVID-19 in Uganda
Introduction: Evidence that supports the use of COVID-19 convalescent plasma (CCP) for treatment of COVID-19 is increasingly emerging.…
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PLOS ONE Duration of SARS-CoV-2 shedding: A population-based, Canadian study
Introduction: There is an evidence gap regarding the duration of SARS-CoV-2 shedding and of its variability across different care settings…
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Image creditFig 1. Patient distribution of the 4704 included patients in Germany. by Gessler et al., CC BY 4.0PLOS ONE Clinical outcome, risk assessment, and seasonal variation in hospitalized COVID-19 patients—Results from the CORONA Germany study
Background: After one year of the pandemic and hints of seasonal patterns, temporal variations of in-hospital mortality in COVID-19 are…
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PLOS ONE A first analysis of excess mortality in Switzerland in 2020
Objective: To quantify excess all-cause mortality in Switzerland in 2020, a key indicator for assessing direct and indirect consequences of…
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PLOS ONE Reduced muscle mass as predictor of intensive care unit hospitalization in COVID-19 patients
Purpose: To evaluate if reduced muscle mass, assessed with Computed Tomography (CT), is a predictor of intensive care unit (ICU)…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE Reported health and social consequences of the COVID-19 pandemic on vulnerable populations and implemented solutions in six West African countries: A media content analysis
Coronavirus has spread worldwide with over 140 million cases and resulting in more than 3 million deaths between November 2019 to April…
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Image creditFig 2. Forest plot of the prevalence of COVID-19 in ESRD patients with RRT. by Nopsopon et al., CC BY 4.0PLOS Neglected Tropical Diseases Covid-19 in end-stage renal disease patients with renal replacement therapies: A systematic review and meta-analysis
Background: The novel coronavirus (COVID-19), caused by SARS-CoV-2, showed various prevalence and case-fatality rates (CFR) among patients…
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PLOS ONE The selection of indicators from initial blood routine test results to improve the accuracy of early prediction of COVID-19 severity
The global pandemic of COVID-19 poses a huge threat to the health and lives of people all over the world, and brings unprecedented…
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PLOS ONE Sex differences in the incidence, mortality, and fatality of COVID-19 in Peru
Background: There is a worrying lack of epidemiological data on the sex differential in COVID-19 infection and death rates between the…
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PLOS ONE Ayurveda botanicals in COVID-19 management: An in silico multi-target approach
The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there…
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Image creditFig 1. Mortality Trends in COVID-19 admissions. by Coppock et al., CC BY 4.0PLOS ONE COVID-19 treatment combinations and associations with mortality in a large multi-site healthcare system
Introduction: During the early months of the COVID-19 pandemic, mortality associated with the disease declined in the United States. The…
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Image creditFig 3. IgG levels in the patients during the three visits. by Alzaabi et al., CC BY 4.0PLOS ONE Longitudinal changes in IgG levels among COVID-19 recovered patients: A prospective cohort study
Objectives: To quantify SARS-CoV2 IgG antibody titers over time and assess the longevity of the immune response in a multi-ethnic…
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PLOS ONE Inactivation of SARS-CoV-2 virus in saliva using a guanidium based transport medium suitable for RT-PCR diagnostic assays
Background: Upper respiratory samples used to test for SARS-CoV-2 virus may be infectious and present a hazard during transport and…
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PLOS ONE Stay-at-home orders associate with subsequent decreases in COVID-19 cases and fatalities in the United States
Governments issue “stay-at-home” orders to reduce the spread of contagious diseases, but the magnitude of such orders’ effectiveness…
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PLOS ONE Automatic algorithm for quantifying lung involvement in patients with chronic obstructive pulmonary disease, infection with SARS-CoV-2, paracoccidioidomycosis and no lung disease patients
In this work, we aimed to develop an automatic algorithm for the quantification of total volume and lung impairments in four different…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE Nurses’ core disaster-response competencies for combating COVID-19—A cross-sectional study
The core competencies in disaster nursing, nurses’ roles in disaster management and the potential barriers are assessed with a view to…
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Image creditFig 1. Stay-at-home measure and number of new infections, Tokyo. by Watanabe and Yabu, CC BY 4.0PLOS ONE Japan’s voluntary lockdown
Japan’s government has taken a number of measures, including declaring a state of emergency, to combat the spread COVID-19. We examine the…
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PLOS ONE COVI-Prim survey: Challenges for Austrian and German general practitioners during initial phase of COVID-19
Background: Coronavirus disease 2019 (COVID-19) represents a significant challenge to health care systems around the world. A…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE Low level SARS-CoV-2 RNA detected in plasma samples from a cohort of Nigerians: Implications for blood transfusion
The present global pandemic triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has lingered for over a year in…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases/NIH, CC-0 Public DomainPLOS ONE Investigation of superspreading COVID-19 outbreak events in meat and poultry processing plants in Germany: A cross-sectional study
Since May 2020, several COVID-19 outbreaks have occurred in the German meat industry despite various protective measures, and temperature…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Seroprevalence of anti-SARS-CoV-2 IgG antibodies in the staff of a public school system in the midwestern United States
Since March 2020, the United States has lost over 580,000 lives to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which…
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PLOS ONE Simulated sunlight decreases the viability of SARS-CoV-2 in mucus
The novel coronavirus, SARS-CoV-2, has spread into a pandemic since its emergence in Wuhan, China in December of 2019. This has been…
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Image creditFig 1. Variability in SARS-CoV-2 IgG antibody response. by Schaefer et al., CC BY 4.0PLOS ONE Corona Virus Disease-19 serology, inflammatory markers, hospitalizations, case finding, and aging
Most deaths from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection occur in older subjects. We assessed the utility…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Screening for SARS-CoV-2 by RT-PCR: Saliva or nasopharyngeal swab? Rapid review and meta-analysis
Background: Diagnosis of COVID-19 in symptomatic patients and screening of populations for SARS-CoV-2 infection require access to…
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PLOS ONE Time to recovery from COVID-19 and its predictors among patients admitted to treatment center of Wollega University Referral Hospital (WURH), Western Ethiopia: Survival analysis of retrospective cohort study
Introduction: Despite its alarming spread throughout the world, no effective drug and vaccine is discovered for COVID-19 so far. According…
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Image creditFig 1. Distribution of treatment modalities over time. by Malhani et al., CC BY 4.0PLOS ONE Combination of (interferon beta-1b, lopinavir/ritonavir and ribavirin) versus favipiravir in hospitalized patients with non-critical COVID-19: A cohort study
Objectives: Our study aims at comparing the efficacy and safety of IFN-based therapy (lopinavir/ritonavir, ribavirin, and interferon β-1b)…
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PLOS ONE Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience
Background: Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their…
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PLOS ONE Detection of SARS-CoV-2 using qRT-PCR in saliva obtained from asymptomatic or mild COVID-19 patients, comparative analysis with matched nasopharyngeal samples
Objectives: The accurate detection of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is essential for the diagnosis of…
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PLOS ONE Lack of efficacy of hydroxychloroquine and azithromycin in patients hospitalized for COVID-19 pneumonia: A retrospective study
Background: Hydroxychloroquine combined with azithromycin (HCQ/AZI) has initially been used against coronavirus disease-2019 (COVID-19). In…
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PLOS ONE Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry
Until now, antiviral therapeutic agents are still urgently required for treatment or prevention of SARS-coronavirus 2 (SCoV-2) virus…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study
Background: COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of…
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PLOS ONE Social, economic, and environmental factors influencing the basic reproduction number of COVID-19 across countries
Objective: To assess whether the basic reproduction number (R0) of COVID-19 is different across countries and what national-level…
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PLOS ONE Severe COVID-19 pneumonia: Perfusion analysis in correlation with pulmonary embolism and vessel enlargement using dual-energy CT data
Background: Gas exchange in COVID-19 pneumonia is impaired and vessel obstruction has been suspected to cause ventilation-perfusion…
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Image creditFig 1. The global model collects local models updates. by Abdul Salam et al., CC BY 4.0PLOS ONE COVID-19 detection using federated machine learning
The current COVID-19 pandemic threatens human life, health, and productivity. AI plays an essential role in COVID-19 case classification…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Excess mortality by specific causes of deaths in the city of São Paulo, Brazil, during the COVID-19 pandemic
Background: To investigate the excess of deaths by specific causes, in the first half of 2020 in the city of São Paulo-Brazil, during the…
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Image creditFig 3. Representative case without COVID-19 pneumonia. by Hwang et al., CC BY 4.0PLOS ONE COVID-19 pneumonia on chest X-rays: Performance of a deep learning-based computer-aided detection system
Chest X-rays (CXRs) can help triage for Coronavirus disease (COVID-19) patients in resource-constrained environments, and a computer-aided…
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PLOS Pathogens Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan
We aimed to investigate novel emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages in Japan that harbor variants…
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PLOS ONE Meteorological factors against COVID-19 and the role of human mobility
In the vein of recent empirical literature, we reassessed the impact of weather factors on Covid-19 daily cases and fatalities in a panel…
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PLOS ONE Excess mortality associated with the COVID-19 pandemic among Californians 18–65 years of age, by occupational sector and occupation: March through November 2020
Background: Though SARS-CoV-2 outbreaks have been documented in occupational settings and in-person essential work has been suspected as a…
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PLOS ONE Characterization of dysphagia and laryngeal findings in COVID-19 patients treated in the ICU—An observational clinical study
Background: Dysphagia appears to be common in patients with severe COVID-19. Information about the characteristics of dysphagia and…
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PLOS ONE Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients
Aims: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) enabling entrance of the…
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PLOS ONE Assessment of depressive symptoms in patients with COVID-19 during the second wave of epidemic in Myanmar: A cross-sectional single-center study
Background: Coronavirus disease 2019 (COVID-19) pandemic has had a great impact on every aspect of society. All countries launched…
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PLOS ONE End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts
Introduction: End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we…
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Image creditFig 1. Schematic diagram of the contact tracing model. by James et al., CC BY 4.0PLOS ONE Successful contact tracing systems for COVID-19 rely on effective quarantine and isolation
Models of contact tracing often over-simplify the effects of quarantine and isolation on disease transmission. We develop a model that…
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Image creditFig 1. Data extraction and processing. by Tortolero et al., CC BY 4.0PLOS ONE Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality
Understanding sociodemographic, behavioral, clinical, and laboratory risk factors in patients diagnosed with COVID-19 is critically…
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Image creditFig 2. PCA plot of IgM and IgG pan-CoV responses. by Chaudhury et al., CC BY 4.0PLOS ONE Serological profiles of pan-coronavirus-specific responses in COVID-19 patients using a multiplexed electro-chemiluminescence-based testing platform
Serological assessment of SARS-CoV-2 specific responses are an essential tool for determining the prevalence of past SARS-CoV-2 infections…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE The benefits of coronavirus suppression: A cost-benefit analysis of the response to the first wave of COVID-19 in the United States
This paper estimates the benefits and costs of state suppression policies to “bend the curve” during the initial outbreak of COVID-19 in…
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Image creditFig 1. Flowchart of patients included in our analysis. by Sen et al., CC BY 4.0PLOS ONE Inhaled corticosteroids do not adversely impact outcomes in COVID-19 positive patients with COPD: An analysis of Cleveland Clinic’s COVID-19 registry
Inhaled Corticosteroids (ICS) are commonly prescribed to patients with severe COPD and recurrent exacerbations. It is not known what…
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PLOS ONE Proof of concept for real-time detection of SARS CoV-2 infection with an electronic nose
Rapid diagnosis is key to curtailing the Covid-19 pandemic. One path to such rapid diagnosis may rely on identifying volatile organic…
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Image creditFig 1. Timing of NPIs by country. by Banholzer et al., CC BY 4.0PLOS ONE Estimating the effects of non-pharmaceutical interventions on the number of new infections with COVID-19 during the first epidemic wave
The novel coronavirus (SARS-CoV-2) has rapidly developed into a global epidemic. To control its spread, countries have implemented…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain
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PLOS ONE Avian antibodies (IgY) targeting spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit receptor binding and viral replication
Background: The global pandemic of Coronavirus infectious disease 2019 (COVID-19), caused by SARS-CoV-2, has plunged the world into both…
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Image creditFig 3. PCA plot (Day 90). by Teh et al., CC BY 4.0PLOS ONE Multivariate visualization of the global COVID-19 pandemic: A comparison of 161 countries
Background: The aim of the study was to visualize the global spread of the COVID-19 pandemic over the first 90 days, through the principal…
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PLOS ONE Validation of a multiplex flow immunoassay for detection of IgG antibodies against SARS-CoV-2 in dried blood spots
Background: Dried blood spots (DBS) are an established specimen type for clinical testing given their low cost, ease of collection and…
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PLOS ONE The Abbott PanBio WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic test for SARS-CoV-2—Evaluation of the accuracy and ease-of-use
Objectives: Diagnostics are essential for controlling the pandemic. Identifying a reliable and fast diagnostic device is needed for…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Determinants of in-hospital mortality in COVID-19; a prospective cohort study from Pakistan
A prospective cohort study was conducted at the Indus Hospital Karachi, Pakistan between March and June 2020 to estimate the in-hospital…
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Image creditSyringe and Vaccine by NIH, CC BY 2.0PLOS ONE Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda
Background: Healthcare workers (HCWs) are at high risk of acquiring SARS-CoV-2 and COVID-19 and may therefore be a suitable population for…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE The systemic inflammatory response and clinicopathological characteristics in patients admitted to hospital with COVID-19 infection: Comparison of 2 consecutive cohorts
Background: In order to manage the COVID-19 systemic inflammatory response, it is important to identify clinicopathological characteristics…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Seroprevalence of SARS-CoV-2 antibodies in Seattle, Washington: October 2019–April 2020
Background: The first US case of SARS-CoV-2 infection was detected on January 20, 2020. However, some serology studies suggest SARS-CoV-2…
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PLOS ONE Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity
To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective…
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Image creditFig 2. The SARS-CoV-2 outbreak in the Netherlands. by Tomokazu Konishi, CC BY 4.0PLOS ONE SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans
SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to…
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PLOS ONE SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains
COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this…
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PLOS ONE Dexamethasone vs methylprednisolone high dose for Covid-19 pneumonia
Background: There is no effective therapy for the severe acute respiratory syndrome by coronavirus 2 (SARS-CoV2) responsible for the…
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PLOS ONE Acute kidney injury: Incidence, risk factors, and outcomes in severe COVID-19 patients
Background: COVID-19 is a multisystemic disorder that frequently causes acute kidney injury (AKI). However, the precise clinical and…
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PLOS Medicine Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity
Michel Goldman and Cédric Hermans discuss thrombotic mechanisms in COVID-19 and rare adverse reactions to SARS-CoV-2…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public Domain
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Image creditFig 1. Forest plot of willingness to vaccinate by demographics. by Nikolovski et al., CC BY 4.0PLOS ONE Factors indicating intention to vaccinate with a COVID-19 vaccine among older U.S. adults
Background: The success of vaccination efforts to curb the COVID-19 pandemic will require broad public uptake of immunization and…
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PLOS ONE Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients
Background: Understanding the false negative rates of SARS-CoV-2 RT-PCR testing is pivotal for the management of the COVID-19 pandemic and…
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PLOS Medicine COVID-19 and excess mortality in the United States: A county-level analysis
Background: Coronavirus Disease 2019 (COVID-19) excess deaths refer to increases in mortality over what would normally have been expected…
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PLOS ONE Current status of community-acquired infection of COVID-19 in delivery facilities in Japan
A nationwide questionnaire survey about community-acquired infection of coronavirus disease 2019 (COVID-19) was conducted in July 2020 to…
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PLOS ONE DPP-4 inhibitors may improve the mortality of coronavirus disease 2019: A meta-analysis
Aims: DPP-4 inhibitors are predicted to exert a protective effect on the progression of coronavirus disease 2019 (COVID-19). We conducted…
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PLOS ONE Value of quantitative analysis in lung computed tomography in patients severely ill with COVID-19
Introduction: Quantitative computed tomography (QCT) is used to objectively assess the degree of parenchymal impairment in COVID-19…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Incidence of deep vein thrombosis through an ultrasound surveillance protocol in patients with COVID-19 pneumonia in non-ICU setting: A multicenter prospective study
Objective: The aim of this study was to assess the incidence of deep vein thrombosis (DVT) of the lower limbs, using serial compression…
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Image creditFig 2. OneR model diagnostic plot. by Herzog et al., CC BY 4.0PLOS ONE COVID-19 and the kidney: A retrospective analysis of 37 critically ill patients using machine learning
Introduction: There is evidence that SARS-CoV2 has a particular affinity for kidney tissue and is often associated with kidney failure.…
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PLOS Pathogens Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While…
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Image creditFig 2. Neuron-Specific Enolase (NSE) serum levels. by Cione et al., CC BY 4.0PLOS ONE Neuron-specific enolase serum levels in COVID-19 are related to the severity of lung injury
The multifunctional role of neuron-specific enolase (NSE) in lung diseases is well established. As the lungs are greatly affected in…
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Image creditPregnant woman by sergio santos, CC BY 2.0PLOS ONE Available medications used as potential therapeutics for COVID-19: What are the known safety profiles in pregnancy
Background: Medications already available to treat other conditions are presently being studied in clinical trials as potential treatments…
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PLOS ONE Adapting for the COVID-19 pandemic in Ecuador, a characterization of hospital strategies and patients
The World Health Organization (WHO) declared coronavirus disease-2019 (COVID-19) a global pandemic on 11 March 2020. In Ecuador, the first…
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PLOS ONE Targeted antiviral treatment using non-ionizing radiation therapy for SARS-CoV-2 and viral pandemics preparedness: Technique, methods and practical notes for clinical application
Objective: Pandemic outbreaks necessitate effective responses to rapidly mitigate and control the spread of disease and eliminate the…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients
We assessed the impact of chest CT body composition parameters on outcomes and disease severity at hospital presentation of COVID-19…
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PLOS ONE Primary health care and social isolation against COVID-19 in Northeastern Brazil: Ecological time-series study
Background: Brazil is witnessing a massive increase of corona virus disease (COVID-19). Its peculiar primary health care (PHC) system faces…
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PLOS ONE Deep reinforcement learning approaches for global public health strategies for COVID-19 pandemic
Background: Unprecedented public health measures have been used during this coronavirus 2019 (COVID-19) pandemic to control the spread of…
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PLOS ONE SARS-CoV-2 antibody immunoassays in serial samples reveal earlier seroconversion in acutely ill COVID-19 patients developing ARDS
Objectives: During the COVID-19 pandemic, SARS-CoV-2 antibody testing has been suggested for (1) screening populations for disease…
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PLOS ONE Clinical course and management of 73 hospitalized moderate patients with COVID-19 outside Wuhan
Moderate cases account for the majority in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
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PLOS ONE Does blood type affect the COVID-19 infection pattern?
Among the many aspects that characterize the COVID-19 pandemic, two seem particularly challenging to understand: i) the great geographical…
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PLOS ONE Evaluation of the test accuracy of a SARS-CoV-2 rapid antigen test in symptomatic community dwelling individuals in the Netherlands
Background: SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction (qRT-PCR) is well suited for the diagnosis of clinically…
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Image creditFig 1. Location of Mutukula border entry point into Uganda. by Nsawotebba et al., CC BY 4.0PLOS ONE Effectiveness of thermal screening in detection of COVID-19 among truck drivers at Mutukula Land Point of Entry, Uganda
Introduction: Despite the limited evidence for its effectiveness, thermal screening at points of entry has increasingly become a standard…
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Image creditFig 1. COVID-19 postmortem donor eye. by Bayyoud et al., CC BY 4.0PLOS ONE Severe acute respiratory Syndrome-Coronavirus-2: Can it be detected in the retina?
Background/Objectives: The systemic organ involvement of SARS-CoV-2 needs to be thoroughly investigated including the possibility of an…
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PLOS ONE SARS-CoV-2 infection in cystic fibrosis: A multicentre prospective study with a control group, Italy, February-July 2020
Objective: To describe the symptoms and clinical course of SARS-CoV-2 infection in patients with cystic fibrosis (CF). Methods: We carried…
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PLOS ONE Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program
Background: The risk factors associated with the stages of Coronavirus Disease-2019 (COVID-19) disease progression are not well known. We…
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PLOS ONE Projecting COVID-19 isolation bed requirements for people experiencing homelessness
As COVID-19 spreads across the United States, people experiencing homelessness (PEH) are among the most vulnerable to the virus. To…
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Image creditFig 1. Epidemic curve of COVID-19 cases at the Djoungolo Hospital. by Fouda Mbarga et al., CC BY 4.0PLOS ONE Clinical profile and factors associated with COVID-19 in Yaounde, Cameroon: A prospective cohort study
Background: A year after the COVID-19 pandemic started, there are still few scientific reports on COVID-19 in Africa. This study explores…
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PLOS ONE Therapy with lopinavir/ritonavir and hydroxychloroquine is associated with acute kidney injury in COVID-19 patients
Background: Acute kidney injury (AKI) is an independent risk factor for mortality, which affects about 5% of hospitalized coronavirus…
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Image creditFig 2. Raspberry Pi 4 model B hardware design. by Hosny et al., CC BY 4.0PLOS ONE COVID-19 diagnosis from CT scans and chest X-ray images using low-cost Raspberry Pi
The diagnosis of COVID-19 is of vital demand. Several studies have been conducted to decide whether the chest X-ray and computed…
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Image creditFig 2. Antibiotic prescription variation over time. by Calderón-Parra et al., CC BY 4.0PLOS ONE Inappropriate antibiotic use in the COVID-19 era: Factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID
Background: Most patients with COVID-19 receive antibiotics despite the fact that bacterial co-infections are rare. This can lead to…
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Image creditFig 2. Locations of ICU responders. by Brewster et al., CC BY 4.0PLOS ONE Preparation for airway management in Australia and New Zealand ICUs during the COVID -19 pandemic
Background: This paper aimed to describe the airway practices of intensive care units (ICUs) in Australia and New Zealand specific to…
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PLOS ONE ai-corona: Radiologist-assistant deep learning framework for COVID-19 diagnosis in chest CT scans
The development of medical assisting tools based on artificial intelligence advances is essential in the global fight against COVID-19…
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PLOS ONE COVID-19 incidence and mortality in the Metropolitan Region, Chile: Time, space, and structural factors
Demographic, health, and socioeconomic factors significantly inform COVID-19 outcomes. This article analyzes the association of these…
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PLOS ONE Prevalence and outcomes of co-infection and superinfection with SARS-CoV-2 and other pathogens: A systematic review and meta-analysis
Introduction: The recovery of other pathogens in patients with SARS-CoV-2 infection has been reported, either at the time of a SARS-CoV-2…
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Image creditFig 1. Sense of preparedness to serve in COVID-19 pandemic. by Barqawi et al., CC BY 4.0PLOS ONE Readiness of physicians and medical students to cope with the COVID-19 pandemic in the UAE
Background: Coronavirus disease (COVID-19), caused by Severe Acute Respiratory Syndrome–Coronavirus 2 (SARS-CoV2), is the defining global…
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PLOS ONE Covichem: A biochemical severity risk score of COVID-19 upon hospital admission
Clinical and laboratory predictors of COVID-19 severity are now well described and combined to propose mortality or severity scores.…
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Image creditFig 1. Geographic location of sample collection sites in this study. by Megasari et al., CC BY 4.0PLOS ONE Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic,…
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PLOS ONE The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study
Background: It has been suggested that cardiorespiratory fitness (CRF) may be used to identify those at greatest risk for severe COVID-19…
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Image creditFig 2. RT-LAMP assay limit of detection. by Uribe-Alvarez et al., CC BY 4.0PLOS ONE Low saliva pH can yield false positives results in simple RT-LAMP-based SARS-CoV-2 diagnostic tests
Diagnosis of any infectious disease is vital for opportune treatment and to prevent dissemination. RT-qPCR tests for detection of…
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PLOS ONE The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: A national cohort study using the UK Obstetric Surveillance System (UKOSS)
Background: There is a lack of population level data on risk factors, incidence and impact of SARS-CoV-2 infection in pregnant women and…
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PLOS ONE Risk factors for COVID-19 among healthcare workers. A protocol for a systematic review and meta-analysis
Background: Evidence on the spectrum of risk factors for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among…
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PLOS ONE Evaluation of potential COVID-19 recurrence in patients with late repeat positive SARS-CoV-2 testing
Background: SARS-CoV-2 reinfection and reactivation has mostly been described in case reports. We therefore investigated the epidemiology…
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Image creditFig 5. Meta-regression by median age of patients. by Li et al., CC BY 4.0PLOS ONE Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis
Objective: We aimed to systematically identify the possible risk factors responsible for severe cases. Methods: We searched PubMed, Embase,…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Low serum albumin and the risk of hospitalization in COVID-19 infection: A retrospective case-control study
Background: The data on the COVID-19 patients who were discharged to self-quarantine is lacking. Aim: The aim of the study was to…
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PLOS ONE Epidemiology, outcomes, and utilization of intensive care unit resources for critically ill COVID-19 patients in Libya: A prospective multi-center cohort study
Background: The coronavirus disease (COVID-19) pandemic has severely affected African countries, specifically the countries, such as Libya,…
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PLOS Biology Validation testing to determine the sensitivity of lateral flow testing for asymptomatic SARS-CoV-2 detection in low prevalence settings: Testing frequency and public health messaging is key
Lateral flow devices (LFDs) are quickly being implemented for use in large-scale population surveillance programs for SARS-CoV-2 infection…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Risk factors for COVID-19 mortality: The effect of convalescent plasma administration
Background: Convalescent plasma, widely utilized in viral infections that induce neutralizing antibodies, has been proposed for COVID-19,…
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PLOS ONE Epidemiological, clinical, and laboratory findings for patients of different age groups with confirmed coronavirus disease 2019 (COVID-19) in a hospital in Saudi Arabia
Background: Although the coronavirus disease 2019 (COVID-19) pandemic continues to rage worldwide, clinical and laboratory studies of this…
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PLOS ONE Assessment of exposure risks to COVID-19 among frontline health care workers in Amhara Region, Ethiopia: A cross-sectional survey
Background: The burden to fight with Corona Virus Disease-19 (COVID-19) pandemic has lied to frontline health care workers that are putting…
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PLOS ONE Sex differences in the case-fatality rates for COVID-19—A comparison of the age-related differences and consistency over seven countries
Background: Early in the COVID-19 pandemic, it was noted that males seemed to have higher case-fatality rates than females. We examined the…
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PLOS ONE Krebs von den Lungen 6 (KL-6) as a marker for disease severity and persistent radiological abnormalities following COVID-19 infection at 12 weeks
Introduction: Acute presentations of COVID-19 infection vary, ranging from asymptomatic carriage through to severe clinical manifestations…
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Image creditFig 1. Age distribution of patients stratified by clinical outcome. by Salto-Alejandre et al., CC BY 4.0PLOS ONE Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study
The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public DomainPLOS ONE Two original observations concerning bacterial infections in COVID-19 patients hospitalized in intensive care units during the first wave of the epidemic in France
Among 197 COVID-19 patients hospitalized in ICU, 88 (44.7%) experienced at least one bacterial infection, with pneumonia (39.1%) and…
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PLOS ONE Case-control study of patient characteristics, knowledge of the COVID-19 disease, risk behaviour and mental state in patients visiting an emergency room with COVID-19 symptoms in the Netherlands
Background: Coronavirus disease 2019 is a serious respiratory virus pandemic. Patient characteristics, knowledge of the COVID-19 disease,…
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PLOS ONE Target specific serologic analysis of COVID-19 convalescent plasma
This study compared the performance of four serology assays for Coronavirus Disease 2019 (COVID-19) and investigated whether COVID-19…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public DomainPLOS ONE Pathological findings in organs and tissues of patients with COVID-19: A systematic review
Background: Coronavirus disease (COVID-19) is the pandemic caused by SARS-CoV-2 that has caused more than 2.2 million deaths worldwide. We…
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PLOS ONE Potential impact of introducing vaccines against COVID-19 under supply and uptake constraints in France: A modelling study
Background: The accelerated vaccine development in response to the COVID-19 pandemic should lead to a vaccine being available early 2021,…
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Image creditFig 1. Blood donor demographics of NYC metro area. by Jin et al., CC BY 4.0PLOS ONE Seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of New York City metro blood donors using multiple SARS-CoV-2 serological assays: Implications for controlling the epidemic and “Reopening”
Projections of the stage of the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic and local, regional and national…
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Image creditthanksgiving dinner-45.jpg by barbbarbbarb, CC BY 2.0PLOS ONE Investigation of SARS-CoV-2 infection in dogs and cats of humans diagnosed with COVID-19 in Rio de Janeiro, Brazil
Background: Infection by SARS-CoV-2 in domestic animals has been related to close contact with humans diagnosed with COVID-19. Objectives:…
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PLOS ONE Hypertension as a sequela in patients of SARS-CoV-2 infection
Background: COVID-19 is a respiratory infectious disease caused by SARS-CoV-2, and cardiovascular damage is commonly observed in affected…
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PLOS ONE Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics…
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PLOS ONE Sex differences in inflammatory markers in patients hospitalized with COVID-19 infection: Insights from the MGH COVID-19 patient registry
Background: Men are at higher risk for serious complications related to COVID-19 infection than women. More robust immune activation in…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public DomainPLOS ONE Willingness to vaccinate against COVID-19 among Bangladeshi adults: Understanding the strategies to optimize vaccination coverage
Background: Although the approved COVID-19 vaccine has been shown to be safe and effective, mass vaccination in Bangladeshi people remains…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain
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Image creditFig 1. Epidemiological characteristics of COVID-19 in Africa. by Lamptey et al., CC BY 4.0PLOS Neglected Tropical Diseases Genomic and epidemiological characteristics of SARS-CoV-2 in Africa
Since late 2019, the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, has rapidly evolved to become a global pandemic.…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public DomainPLOS Neglected Tropical Diseases Distinguishing non severe cases of dengue from COVID-19 in the context of co-epidemics: A cohort study in a SARS-CoV-2 testing center on Reunion island
Background: As coronavirus 2019 (COVID-19) is spreading globally, several countries are handling dengue epidemics. As both infections are…
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Image creditFig 1. Number of deaths in 2020 according to age class. by Costantino et al., CC BY 4.0PLOS ONE Utility of hospitalization for elderly individuals affected by COVID-19
Background: During the COVID-19 pandemic, the number of individuals needing hospital admission has sometimes exceeded the availability of…
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PLOS ONE Correlation of national and healthcare workers COVID-19 infection data; implications for large-scale viral testing programs
Time analysis of the course of an infectious disease epidemic is a critical way to understand the dynamics of pathogen transmission and…
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PLOS ONE Angiotensin II receptor blocker or angiotensin-converting enzyme inhibitor use and COVID-19-related outcomes among US Veterans
Background: Angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) may positively or negatively…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public DomainPLOS ONE Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review
Introduction: The evidence for vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is not well…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public DomainPLOS ONE Prevalence, clinical features, and outcomes of SARS-CoV-2 infection in pregnant women with or without mild/moderate symptoms: Results from universal screening in a tertiary care center in Mexico City, Mexico
The perinatal consequences of SARS-CoV-2 infection are still largely unknown. This study aimed to describe the features and outcomes of…
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Image creditFig 1. Model flow chart. by Tsoungui Obama et al., CC BY 4.0PLOS ONE Preventing COVID-19 spread in closed facilities by regular testing of employees—An efficient intervention in long-term care facilities and prisons?
Background: Different levels of control measures were introduced to contain the global COVID-19 pandemic, many of which have been…
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Image creditFig 1. Seroprevalence of COVID-19 in the military police of Rio Grande do Sul. by Pasqualotto et al., CC BY 4.0PLOS ONE COVID-19 seroprevalence in military police force, Southern Brazil
Background: Limited data is available regarding the frequency of COVID-19 in populations that are highly exposed to SARS-CoV-2. In this…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public DomainPLOS ONE SARS-CoV-2 testing strategy: A comparison of restricted and extended strategies in a Swiss outpatient cohort from the community and hospital employees
Background: Testing is a key measure to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we…
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Image creditFig 2. Groups of susceptible and immunized individuals. by Adil Mahmoud Yousif et al., CC BY 4.0PLOS ONE The impact of COVID-19 vaccination campaigns accounting for antibody-dependent enhancement
Background: COVID-19 vaccines are approved, vaccination campaigns are launched, and worldwide return to normality seems within close reach.…
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PLOS ONE High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity
SARS-CoV-2 has caused a global pandemic, and has taken over 1.7 million lives as of mid-December, 2020. Although great progress has been…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Clinical characteristics and outcomes of patients with Corona Virus Disease 2019 (COVID-19) at Mercy Health Hospitals, Toledo, Ohio
Importance: The ongoing pandemic of the novel Corona Virus Disease 2019 (COVID-19) is an unprecedented challenge to global health, never…
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PLOS Biology Evaluation of COVID-19 vaccination strategies with a delayed second dose
Two of the Coronavirus Disease 2019 (COVID-19) vaccines currently approved in the United States require 2 doses, administered 3 to 4 weeks…
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PLOS ONE The proportion and effect of corticosteroid therapy in patients with COVID-19 infection: A systematic review and meta-analysis
Objectives: Coronavirus disease 2019 (COVID-19) remains a global challenge. Corticosteroids constitute a group of anti-inflammatory and…
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PLOS ONE COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load
Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to…
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PLOS ONE Population density and basic reproductive number of COVID-19 across United States counties
The basic reproductive number (R0) is a function of contact rates among individuals, transmission probability, and duration of…
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PLOS ONE The Perme Mobility Index: A new concept to assess mobility level in patients with coronavirus (COVID-19) infection
Introduction: The Coronavirus Disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. Data on the mobility level of patients with…
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PLOS ONE Investigation and public health response to a COVID-19 outbreak in a rural resort community—Blaine County, Idaho, 2020
Blaine County, Idaho, a rural area with a renowned resort, experienced a COVID-19 outbreak early in the pandemic. We undertook an…
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Image creditFig 1. Research framework of the study. by Ramatillah and Isnaini, CC BY 4.0PLOS ONE Treatment profiles and clinical outcomes of COVID-19 patients at private hospital in Jakarta
Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a virus that causes COVID-19, which has become a worldwide…
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PLOS ONE Clinical characteristics of Egyptian male patients with COVID‐19 acute respiratory distress syndrome
Background: Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
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PLOS Pathogens Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease severity
The SARS-CoV-2 infection causes severe respiratory involvement (COVID-19) in 5–20% of patients through initial immune derangement,…
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PLOS Neglected Tropical Diseases Deciphering the introduction and transmission of SARS-CoV-2 in the Colombian Amazon Basin
Background: The SARS-CoV-2 pandemic has forced health authorities across the world to take important decisions to curtail its spread.…
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PLOS ONE Demographic, clinical, and epidemiologic characteristics of persons under investigation for Coronavirus Disease 2019—United States, January 17–February 29, 2020
Background: The Coronavirus Disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2),…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE A qualitative study of the first batch of medical assistance team’s first-hand experience in supporting the nursing homes in Wuhan against COVID-19
Background: The pandemic of coronavirus disease 2019 (COVID-19) has global impact, Wuhan in Hubei province is a high-risk area. And the…
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PLOS ONE Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S.
Patients on dialysis are at high risk for death due to COVID-19, yet a significant proportion do survive as evidenced by presence of…
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PLOS ONE I-FABP is decreased in COVID-19 patients, independently of the prognosis
Background: Severe acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) is frequently associated with gastrointestinal…
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PLOS ONE Versatile and flexible microfluidic qPCR test for high-throughput SARS-CoV-2 and cellular response detection in nasopharyngeal swab samples
The emergence and quick spread of SARS-CoV-2 has pointed at a low capacity response for testing large populations in many countries, in…
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PLOS ONE Impact of COVID-19 on the hospitalization, treatment, and outcomes of intracerebral and subarachnoid hemorrhage in the United States
Objective: To examine the outcomes of adult patients with spontaneous intracranial and subarachnoid hemorrhage diagnosed with comorbid…
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PLOS ONE Mask adherence and rate of COVID-19 across the United States
Mask wearing has been advocated by public health officials as a way to reduce the spread of COVID-19. In the United States, policies on…
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Image creditFig 2. Close up of port on scent wheel. by Essler et al., CC BY 4.0PLOS ONE Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study
While the world awaits a widely available COVID-19 vaccine, availability of testing is limited in many regions and can be further…
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PLOS ONE Low risk of SARS-CoV-2 in blood transfusion
Background: The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2),…
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Image creditFig 1. Viral copies and Ct values in mask and NPS samples. by Sriraman et al., CC BY 4.0PLOS ONE Non-invasive adapted N-95 mask sampling captures variation in viral particles expelled by COVID-19 patients: Implications in understanding SARS-CoV2 transmission
Infectious respiratory particles expelled by SARS-CoV-2 positive patients are attributed to be the key driver of COVID-19 transmission.…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Knowledge, preventive behaviors and risk perception of the COVID-19 pandemic: A cross-sectional study in Turkish health care workers
The coronavirus disease 2019 (COVID-19) outbreak spread to over 100 countries with a total of 100,000 cases during the first week of March…
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PLOS ONE SARS-CoV-2 infection dynamics in Denmark, February through October 2020: Nature of the past epidemic and how it may develop in the future
Background: Initially, the relative sizes of the asymptomatic and the symptomatic infected populations were not known for the COVID-19…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Similar incidence of coronavirus disease 2019 (COVID-19) in patients with rheumatic diseases with and without hydroxychloroquine therapy
Background: Hydroxychloroquine is not efficacious as post-exposure prophylaxis against coronavirus disease 2019 (COVID-19). It is not known…
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PLOS ONE What about tocilizumab? A retrospective study from a NYC Hospital during the COVID-19 outbreak
Background: Tocilizumab, an interleukin-6 receptor blocker, has been used in the inflammatory phase of COVID-19, but its impact independent…
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PLOS ONE Placing sensors in sewer networks: A system to pinpoint new cases of coronavirus
We consider a proposed system that would place sensors in a number of wastewater manholes in a community in order to detect genetic…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Prevalence of SARS-COV-2 positivity in 516 German intensive care and emergency physicians studied by seroprevalence of antibodies National Covid Survey Germany (NAT-COV-SURV)
Healthcare personnel are at risk to aquire the corona virus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome…
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Image creditFig 1. Days from admission to the appearance of neurologic events. by Flores-Silva et al., CC BY 4.0PLOS ONE Neurologic manifestations in hospitalized patients with COVID-19 in Mexico City
Background: The coronavirus disease 2019 (COVID-19) is a systemic entity that frequently implies neurologic features at presentation and…
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PLOS ONE Evaluation of rapid SARS-CoV-2 antigen tests, AFIAS COVID-19 Ag and ichroma COVID-19 Ag, with serial nasopharyngeal specimens from COVID-19 patients
We evaluated the diagnostic accuracy of two newly developed, point-of-care, rapid antigen tests (RATs) for detecting SARS-CoV-2, the AFIAS…
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Image creditFig 2. Comparison of COVID-19 and post-COVID-19 symptoms. by Mahmud et al., CC BY 4.0PLOS ONE Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary care center of Bangladesh
Background: Post-coronavirus disease (COVID-19) syndrome includes persistence of symptoms beyond viral clearance and fresh development of…
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PLOS ONE Clinical utility of targeted SARS-CoV-2 serology testing to aid the diagnosis and management of suspected missed, late or post-COVID-19 infection syndromes: Results from a pilot service implemented during the first pandemic wave
During the first wave of the global COVID-19 pandemic the clinical utility and indications for SARS-CoV-2 serological testing were not…
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PLOS ONE O group is a protective factor for COVID19 in Basque population
ABO blood groups have recently been related to COVID19 infection. In the present work, we performed this analysis using data from 412…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public DomainPLOS ONE Association of ABO blood groups with presentation and outcomes of confirmed SARS CoV-2 infection: A prospective study in the largest COVID-19 dedicated hospital in Bangladesh
Background: Globally, studies have shown conflicting results regarding the association of blood groups with SARS CoV-2 infection.…
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Image creditFig 3. SARS-CoV-2 intrahost single nucleotide variant (iSNV) diversity. by Valesano et al., CC BY 4.0PLOS Pathogens Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts
Analysis of SARS-CoV-2 genetic diversity within infected hosts can provide insight into the generation and spread of new viral variants…
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PLOS ONE Prevalence and characteristics of fever in adult and paediatric patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis of 17515 patients
Background: Coronavirus disease 2019 (COVID-19), a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 started…
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Image creditFig 1. Seroprevalence of antibodies to SARS-CoV-2. by Hiki et al., CC BY 4.0PLOS ONE Seroprevalence of anti-SARS-CoV-2 antibodies in Japanese COVID-19 patients
Objectives: To determine the seroprevalence of anti-SARS-CoV-2 IgG and IgM antibodies in symptomatic Japanese COVID-19 patients. Methods:…
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Image creditFig 1. Correlation between IL-6 and NLR. by Garcia-Gordillo et al., CC BY 4.0PLOS ONE COVID-IRS: A novel predictive score for risk of invasive mechanical ventilation in patients with COVID-19
Background: Coronavirus disease 2019 (COVID-19) is a systemic disease that can rapidly progress into acute respiratory failure and death.…
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PLOS ONE Clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection: A multi-center study
Objective: To understand the clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection (CDBC), and…
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PLOS ONE Comparative analysis of various clinical specimens in detection of SARS-CoV-2 using rRT-PCR in new and follow up cases of COVID-19 infection: Quest for the best choice
Background: An appropriate specimen is of paramount importance in Real Time reverse transcription-polymerase chain reaction (rRT-PCR) based…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public DomainPLOS ONE Evaluation of the Abbott BinaxNOW rapid antigen test for SARS-CoV-2 infection in children: Implications for screening in a school setting
Background: Rapid antigen tests hold much promise for use in the school environment. However, the performance of these tests in…
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PLOS ONE Comparison of seroprevalence of SARS-CoV-2 infections with cumulative and imputed COVID-19 cases: Systematic review
Background: Accurate seroprevalence estimates of SARS-CoV-2 in different populations could clarify the extent to which current testing…
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Image creditFig 1. Daily cumulative number of first reported case COVID-19 and school closure. by Nazif-Muñoz et al., CC BY 4.0PLOS ONE The global viralization of policies to contain the spreading of the COVID-19 pandemic: Analyses of school closures and first reported cases
Background: On January 30th 2020, the World Health Organization (WHO) declared a international health emergency due to the unprecedented…
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PLOS ONE Seroprevalence of hospital staff in a province with zero COVID-19 cases
Background: COVID-19 seroprevalence data, particularly in less developed countries with a relatively low incidence, has been scant. We…
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Image creditFig 1. Ranking of counties based on health indicators. by Bhowmik et al., CC BY 4.0PLOS ONE A comprehensive analysis of COVID-19 transmission and mortality rates at the county level in the United States considering socio-demographics, health indicators, mobility trends and health care infrastructure attributes
Background: Several research efforts have evaluated the impact of various factors including a) socio-demographics, (b) health indicators,…
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Image creditFig 2. COVID-19 outbreak examples. by Gros et al., CC BY 4.0PLOS ONE Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities
The distinct ways the COVID-19 pandemic has been unfolding in different countries and regions suggest that local societal and governmental…
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PLOS ONE Semi-supervised learning for an improved diagnosis of COVID-19 in CT images
Coronavirus disease 2019 (COVID-19) has been spread out all over the world. Although a real-time reverse-transcription polymerase chain…
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Image creditFig 1. A weekly timeline of the COVID-19 epidemic. by Kasztelewicz et al., CC BY 4.0PLOS ONE Prevalence of IgG antibodies against SARS-CoV-2 among healthcare workers in a tertiary pediatric hospital in Poland
Data on the prevalence of the SARS-CoV-2 antibody in healthcare workers (HCWs) is scarce, especially in pediatric settings. The purpose of…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public DomainPLOS ONE Baseline cardiometabolic profiles and SARS-CoV-2 infection in the UK Biobank
Background: SARS-CoV-2 is a rapidly spreading coronavirus responsible for the Covid-19 pandemic, which is characterized by severe…
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PLOS ONE Machine learning methods to predict mechanical ventilation and mortality in patients with COVID-19
Background: The Coronavirus disease 2019 (COVID-19) pandemic has affected millions of people across the globe. It is associated with a high…
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PLOS Neglected Tropical Diseases SARS-CoV-2 Serological testing in frontline health workers in Zimbabwe
Background: In order to protect health workers from SARS-CoV-2, there is need to characterise the different types of patient facing health…
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PLOS ONE Experiences and needs of persons living with a household member infected with SARS-CoV-2: A mixed method study
Background: Households are important sites for transmission of SARS-CoV-2 and preventive measures are recommended. This study aimed to 1)…
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Image creditFig 1. Score plot: PC2 vs. PC1. by Lusczek et al., CC BY 4.0PLOS ONE Characterizing COVID-19 clinical phenotypes and associated comorbidities and complication profiles
Purpose: Heterogeneity has been observed in outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19). Identification of…
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Image creditFig 1. Study model. by Feldman et al., CC BY 4.0PLOS ONE Endotracheal intubation of COVID-19 patients by paramedics using a box barrier: A randomized crossover manikin study
Background: In the prehospital setting, endotracheal intubation (ETI) may be required to secure the coronavirus disease 2019 (COVID-19)…
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PLOS ONE Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
Objective: Severe acute respiratory syndrome virus (SARS-CoV-2) has infected millions of people worldwide. Our goal was to identify risk…
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PLOS ONE First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain
Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with a first wave during…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC BY 4.0PLOS ONE Functional outcomes in the inpatient rehabilitation setting following severe COVID-19 infection
Objective: To characterize the functional impairments of a cohort of patients undergoing inpatient rehabilitation after surviving severe…
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PLOS ONE Seroprevalence of COVID-19 infection in a rural district of South India: A population-based seroepidemiological study
Objectives: We aimed to estimate the seroprevalence of COVID-19 in a rural district of South India, six months after the index case.…
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PLOS ONE Diagnostic accuracy of two commercial SARS-CoV-2 antigen-detecting rapid tests at the point of care in community-based testing centers
Objectives: Determine the diagnostic accuracy of two antigen-detecting rapid diagnostic tests (Ag-RDT) for SARS-CoV-2 at the point of care…
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PLOS ONE The effectiveness of public health interventions against COVID-19: Lessons from the Singapore experience
Background: In dealing with community spread of COVID-19, two active interventions have been attempted or advocated—containment, and…
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Image creditFig 2. Adherence to behavioral NPIs to mitigate Covid-19 and subsequent mortality increases over three months in eight countries: (A) Percentage of adult population with strong or very strong self-reported adherence on June 1, 2020; (B) Percentage increase in reported Covid-19 mortality from June 1 to August 31, 2020. by Margraf et al., CC BY 4.0PLOS ONE Adherence to behavioral Covid-19 mitigation measures strongly predicts mortality
In the absence of vaccines or causal therapies, behavioral measures such as wearing face masks and maintaining social distance are central…
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PLOS ONE Evaluation of the basic assay performance of the GeneSoc® rapid PCR testing system for detection of severe acute respiratory syndrome coronavirus 2
In the ongoing coronavirus disease 2019 (COVID-19) pandemic, PCR has been widely used for screening patients displaying relevant symptoms.…
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Image creditFig 1. Comparison of sampling into VTM vs. NSLB. by Erster et al., CC BY 4.0PLOS ONE Improved sensitivity, safety, and rapidity of COVID-19 tests by replacing viral storage solution with lysis buffer
Conducting numerous, rapid, and reliable PCR tests for SARS-CoV-2 is essential for our ability to monitor and control the current COVID-19…
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Image creditFig 1. ROC curve for lab parameters. by Malik et al., CC BY 4.0PLOS ONE Thyroid function analysis in COVID-19: A retrospective study from a single center
Background and objective: Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the…
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Image creditFig 1. SARS-CoV and SARS-CoV-2 replication kinetics in hAEC cultures. by V'kovski et al., CC BY 4.0PLOS Biology Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium
Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major…
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PLOS Computational Biology On realized serial and generation intervals given control measures: The COVID-19 pandemic case
The SARS-CoV-2 pathogen is currently spreading worldwide and its propensity for presymptomatic and asymptomatic transmission makes it…
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Image creditFig 2. Contact rate matrix. by Lee et al., CC BY 4.0PLOS ONE The effect of control measures on COVID-19 transmission in South Korea
Countries around the world have taken control measures to mitigate the spread of COVID-19, including Korea. Social distancing is…
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PLOS ONE Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent
The coronavirus disease 2019 (COVID-19) outbreak in North, Central, and South America has become the epicenter of the current pandemic. We…
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PLOS ONE Transmission and control pressure analysis of the COVID-19 epidemic situation using multisource spatio-temporal big data
Taking the Guangdong-Hong Kong-Macao Greater Bay Area as the research area, this paper used OD cluster analysis based on Baidu migration…
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Image creditFig 2. SARS-CoV-2 imported and circulating clades. by Zuckerman et al., CC BY 4.0PLOS ONE Genomic variation and epidemiology of SARS-CoV-2 importation and early circulation in Israel
Severe acute respiratory disease coronavirus 2 (SARS-CoV-2) which causes corona virus disease (COVID-19) was first identified in Wuhan,…
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PLOS ONE An emergency system for monitoring pulse oximetry, peak expiratory flow, and body temperature of patients with COVID-19 at home: Development and preliminary application
Background: COVID-19 is characterized by a rapid change in the patient’s condition, with major changes occurring over a few days. We aimed…
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PLOS ONE Risk factors for in-hospital mortality in laboratory-confirmed COVID-19 patients in the Netherlands: A competing risk survival analysis
Background: To date, survival data on risk factors for COVID-19 mortality in western Europe is limited, and none of the published survival…
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PLOS Pathogens Sex- and age-specific clinical and immunological features of coronavirus disease 2019
To simultaneously determine clinical and immunological responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection…
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Image creditFig 2. SARS-CoV-2 evolution. by Rolland and Gilbert, CC BY 4.0
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE ICU outcomes and survival in patients with severe COVID-19 in the largest health care system in central Florida
Background: Observational studies have consistently described poor clinical outcomes and increased ICU mortality in patients with severe…
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PLOS ONE App-based symptom tracking to optimize SARS-CoV-2 testing strategy using machine learning
Background: Tests are scarce resources, especially in low and middle-income countries, and the optimization of testing programs during a…
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PLOS ONE Superspreading of SARS-CoV-2 in the USA
A number of epidemics, including the SARS-CoV-1 epidemic of 2002-2004, have been known to exhibit superspreading, in which a small…
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PLOS ONE SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy
We report onset, course, correlations with comorbidities, and diagnostic accuracy of nasopharyngeal swab in 539 individuals suspected to…
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PLOS ONE Utilization of in- and outpatient hospital care in Germany during the Covid-19 pandemic insights from the German-wide Helios hospital network
Background: During the early phase of the Covid-19 pandemic, reductions of hospital admissions with a focus on emergencies have been…
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PLOS ONE Neutralizing antibodies for SARS-CoV-2 in stray animals from Rio de Janeiro, Brazil
The epidemic of coronavirus disease 2019 (COVID-19), caused by a novel Betacoronavirus named severe acute respiratory syndrome coronavirus…
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Image creditFig 1. Vaccine constructs and vaccination schedule. by Kurup et al., CC BY 4.0PLOS Pathogens Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although…
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PLOS ONE Model-free estimation of COVID-19 transmission dynamics from a complete outbreak
New Zealand had 1499 cases of COVID-19 before eliminating transmission of the virus. Extensive contract tracing during the outbreak has…
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PLOS ONE Spatial and temporal trends in social vulnerability and COVID-19 incidence and death rates in the United States
Background: Socially vulnerable communities may be at higher risk for COVID-19 outbreaks in the US. However, no prior studies examined…
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Image creditFig 4. Linear trajectories of IL-6. by Manenti et al., CC BY 4.0PLOS ONE Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study
Objectives: Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed. We hypothesized that colchicine, by…
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PLOS ONE Symptoms and symptom clusters associated with SARS-CoV-2 infection in community-based populations: Results from a statewide epidemiological study
Background: Prior studies examining symptoms of COVID-19 are primarily descriptive and measured among hospitalized individuals.…
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Image creditFig 3. Box plot (left) and ROC curves for Energy (right). by Aragón-Benedí et al., CC BY 4.0PLOS ONE Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study
Introduction: The analysis of heart rate variability (HRV) has proven to be an important tool for the management of autonomous nerve system…
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Image creditFig 1. WA State DOH COVID-19 confirmed cases by age: 3/1/2020-4/19/2020. by Malmgren et al., CC BY 4.0PLOS ONE Continued proportional age shift of confirmed positive COVID-19 incidence over time to children and young adults: Washington State March—August 2020
Background: As the coronavirus (COVID-19) epidemic passed initial infection peak in Washington State, phased re-opening lifted stay-at-home…
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Image creditFig 1. ROC curve of multivariable logistic regression model. by Betti et al., CC BY 4.0PLOS ONE Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study
Background: Individual differences in susceptibility to SARS-CoV-2 infection, symptomatology and clinical manifestation of COVID-19 have…
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PLOS ONE Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients
SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant…
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PLOS ONE Magnitude of asymptomatic COVID-19 cases throughout the course of infection: A systematic review and meta-analysis
Background: Asymptomatic SARS-CoV-2 infections are responsible for potentially significant transmission of COVID-19. Worldwide, a number of…
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PLOS ONE Fatality and risk features for prognosis in COVID-19 according to the care approach – a retrospective cohort study
Introduction: This study analyzed the impact of a categorized approach, based on patients’ prognosis, on major outcomes and explanators in…
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PLOS ONE The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT
The characteristics and evolution of pulmonary fibrosis in patients with coronavirus disease 2019 (COVID-19) have not been adequately…
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Image creditFig 1. Relative levels of absorbance from day 0 to day 28. by Bläckberg et al.g, CC BY 4.0PLOS ONE Antibody kinetics and clinical course of COVID-19 a prospective observational study
Background: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19.…
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PLOS Pathogens SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event
The first case of SARS-CoV-2 in Basel, Switzerland was detected on February 26th 2020. We present a phylogenetic study to explore viral…
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PLOS Computational Biology Optimal timing of one-shot interventions for epidemic control
The interventions and outcomes in the ongoing COVID-19 pandemic are highly varied. The disease and the interventions both impose costs and…
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PLOS ONE The effect of age on the clinical and immune characteristics of critically ill patients with COVID-19: A preliminary report
Background: In December 2019, a new disease named coronavirus disease 2019 (COVID-19) was occurred. Patients who are critically ill with…
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Image creditFig 2. Mobility statistics in Tokyo at 15:00: a. (March 13, 2020), b. (April 23, 2020). by Kajitani and Hatayama, CC BY 4.0PLOS ONE Explaining the effective reproduction number of COVID-19 through mobility and enterprise statistics: Evidence from the first wave in Japan
This study uses mobility statistics combined with business census data for the eight Japanese prefectures with the highest coronavirus…
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PLOS ONE Association between thrombocytopenia and 180-day prognosis of COVID-19 patients in intensive care units: A two-center observational study
Background: Thrombocytopenia has been proved to be associated with hospital mortality in patients with severe acute respiratory syndrome…
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PLOS ONE SARS-CoV-2 is associated with high viral loads in asymptomatic and recently symptomatic healthcare workers
Background: Healthcare workers (HCW) are at increased risk of SARS-CoV-2 infection from both patients and other HCW with coronavirus…
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PLOS ONE On the analysis of mortality risk factors for hospitalized COVID-19 patients: A data-driven study using the major Brazilian database
Background: Brazil became the epicenter of the COVID-19 epidemic in a brief period of a few months after the first officially registered…
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PLOS ONE Clinical characteristics and outcomes of 952 hospitalized COVID-19 patients in The Netherlands: A retrospective cohort study
Objective: To describe clinical characteristics, disease course and outcomes in a large and well-documented cohort of hospitalized COVID-19…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE The association of COVID-19 occurrence and severity with the use of angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers in patients with hypertension
Background: A number of studies have reported the association between the use of angiotensin-converting enzyme inhibitor (ACEI) and…
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PLOS Computational Biology SARS-CoV-2 viral dynamics in non-human primates
Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the…
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PLOS ONE Invasive pulmonary aspergillosis in critically ill patients with severe COVID-19 pneumonia: Results from the prospective AspCOVID-19 study
Background: Superinfections, including invasive pulmonary aspergillosis (IPA), are well-known complications of critically ill patients with…
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PLOS ONE Estimating the basic reproduction number for COVID-19 in Western Europe
Objective: To estimate the basic reproduction number (R0) for COVID-19 in Western Europe. Methods: Data (official statistics) on the…
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PLOS ONE Understanding the clinical and demographic characteristics of second coronavirus spike in 192 patients in Tehran, Iran: A retrospective study
During the last months of the coronavirus pandemic, with all those public restrictions and health interventions, the transmission of…
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PLOS ONE Validation of an admission coagulation panel for risk stratification of COVID-19 patients
Background: There is limited data on the markers of coagulation and hemostatic activation (MOCHA) profile in Coronavirus disease 2019…
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Image creditFig 3. Age distribution by treatment group. by Stewart et al., CC BY 4.0PLOS ONE COVID-19 Evidence Accelerator: A parallel analysis to describe the use of Hydroxychloroquine with or without Azithromycin among hospitalized COVID-19 patients
Background: The COVID-19 pandemic remains a significant global threat. However, despite urgent need, there remains uncertainty surrounding…
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Image creditFig 5. Predictions for air freight in the U.S. by Meng et al., CC BY 4.0PLOS ONE Impact of different control policies for COVID-19 outbreak on the air transportation industry: A comparison between China, the U.S. and Singapore
Many countries have been implementing various control measures with different strictness levels to prevent the coronavirus disease 2019…
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PLOS ONE Predictors of infection, symptoms development, and mortality in people with SARS-CoV-2 living in retirement nursing homes
Introduction: Since the start of the pandemic, millions of people have been infected, with thousands of deaths. Many foci worldwide have…
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Image creditFig 1. Flowchart of inclusion and exclusion criteria. by Kheir et al., CC BY 4.0PLOS ONE Higher albumin levels on admission predict better prognosis in patients with confirmed COVID-19
Background: Research surrounding COVID-19 (coronavirus disease 2019) is rapidly increasing, including the study of biomarkers for…
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PLOS ONE Accurate point-of-care serology tests for COVID-19
Background: As COVID-19 vaccines become available, screening individuals for prior COVID-19 infection and vaccine response in point-of-care…
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PLOS ONE Outcomes of COVID-19 patients with comorbidities in southwest Nigeria
Background: Data on the comorbidities that result in negative outcomes for people with COVID-19 are currently scarce for African…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Laboratory biomarkers of COVID-19 disease severity and outcome: Findings from a developing country
Aim: To identify laboratory biomarkers that predict disease severity and outcome among COVID-19 patients admitted to the Millennium…
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PLOS Biology Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen
Virus host shifts are generally associated with novel adaptations to exploit the cells of the new host species optimally. Surprisingly,…
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PLOS ONE Knowledge, practice and associated factors towards the prevention of COVID-19 among high-risk groups: A cross-sectional study in Addis Ababa, Ethiopia
Background: Coronavirus disease (COVID-19) is a highly transmittable virus that continues to disrupt livelihoods, particularly those of…
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PLOS ONE Clinical decision support tool for diagnosis of COVID-19 in hospitals
Background: The coronavirus infectious disease 19 (COVID-19) pandemic has resulted in significant morbidities, severe acute respiratory…
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PLOS ONE Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
Background: COVID-19 is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world.…
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PLOS Pathogens Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort
SARS-CoV-2 virus is transmitted in closed settings to people in contact with COVID-19 patients such as healthcare workers and household…
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PLOS Neglected Tropical Diseases Epidemiological and clinical features in patients with coronavirus disease 2019 outside of Wuhan, China: Special focus in asymptomatic patients
Objectives: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan City and rapidly spread across the world. The clinical…
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Image creditFig 1. Flowchart of the study. by Gülbay et al., CC BY 4.0PLOS ONE A CT radiomics analysis of COVID-19-related ground-glass opacities and consolidation: Is it valuable in a differential diagnosis with other atypical pneumonias?
Purpose: To evaluate the discrimination of parenchymal lesions between COVID-19 and other atypical pneumonia (AP) by using only radiomics…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Prevalence of COVID-19 in adolescents and youth compared with older adults in states experiencing surges
Purpose: There has been considerable controversy regarding susceptibility of adolescents (10–19 years) and youth (15–24 years) to COVID-19.…
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Image creditFig 1. The CORC score by number of points. by Kline et al., CC BY 4.0PLOS ONE Clinical prediction rule for SARS-CoV-2 infection from 116 U.S. emergency departments 2-22-2021
Objectives: Accurate and reliable criteria to rapidly estimate the probability of infection with the novel coronavirus-2 that causes the…
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PLOS Computational Biology Assessing the feasibility and effectiveness of household-pooled universal testing to control COVID-19 epidemics
Outbreaks of SARS-CoV-2 are threatening the health care systems of several countries around the world. The initial control of SARS-CoV-2…
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PLOS ONE Health professionals practice and associated factors towards precautionary measures for COVID-19 pandemic in public health facilities of Gamo zone, southern Ethiopia: A cross-sectional study
Introduction: Coronavirus disease-2019 (COVID-19) is a highly contagious acute respiratory disease, which caused by a novel coronavirus.…
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PLOS ONE Infection prevention and control compliance among exposed healthcare workers in COVID-19 treatment centers in Ghana: A descriptive cross-sectional study
Compliance with infection prevention and control (IPC) protocols is critical in minimizing the risk of coronavirus disease (COVID-19)…
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PLOS ONE Control strategies for COVID-19 epidemic with vaccination, shield immunity and quarantine: A metric temporal logic approach
Ever since the outbreak of the COVID-19 epidemic, various public health control strategies have been proposed and tested against the…
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PLOS Computational Biology Group testing as a strategy for COVID-19 epidemiological monitoring and community surveillance
We propose an analysis and applications of sample pooling to the epidemiologic monitoring of COVID-19. We first introduce a model of the…
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PLOS Computational Biology Age-structured non-pharmaceutical interventions for optimal control of COVID-19 epidemic
In an epidemic, individuals can widely differ in the way they spread the infection depending on their age or on the number of days they…
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PLOS Medicine Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis
Background: Epidemiological studies report associations of diverse cardiometabolic conditions including obesity with COVID-19 illness, but…
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Image creditFig 1. Graphical abstract. by Refat et al., CC BY 4.0PLOS ONE Quercetin/Zinc complex and stem cells: A new drug therapy to ameliorate glycometabolic control and pulmonary dysfunction in diabetes mellitus: Structural characterization and genetic studies
Medicinal uses and applications of metals and their complexes are of increasing clinical and commercial importance. The ligation behavior…
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PLOS ONE Estimating force of infection from serologic surveys with imperfect tests
Background: The force of infection, or the rate at which susceptible individuals become infected, is an important public health measure for…
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PLOS ONE A study on the effects of containment policies and vaccination on the spread of SARS-CoV-2
This paper presents a method to predict the spread of the SARS-CoV-2 in a population with a known age-structure, and then, to quantify the…
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PLOS ONE Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma
Background: Neutralizing-antibody (nAb) is the major focus of most ongoing COVID-19 vaccine trials. However, nAb response against…
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Image creditFig 1. Schematic of Easy Check COVID-19 IgM/IgGTM lateral flow assay. by Higgins et al., CC BY 4.0PLOS ONE Longitudinal SARS-CoV-2 antibody study using the Easy Check COVID-19 IgM/IgG™ lateral flow assay
Since the initial identification of the novel coronavirus SARS-CoV-2 in December of 2019, researchers have raced to understand its…
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PLOS ONE Novel outpatient management of mild to moderate COVID-19 spares hospital capacity and safeguards patient outcome: The Geneva PneumoCoV-Ambu study
Background: Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes coronavirus disease (COVID-19), is…
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PLOS ONE Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis
Aim: COVID-19 clinical presentation is heterogeneous, ranging from asymptomatic to severe cases. While there are a number of early…
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Image creditFig 2. Time from enrollment to key secondary outcomes. by Balcells et al., CC BY 4.0PLOS Medicine Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial
Background: Convalescent plasma (CP), despite limited evidence on its efficacy, is being widely used as a compassionate therapy for…
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PLOS ONE Impact of multiple waves of COVID-19 on healthcare networks in the United States
The risk of overwhelming hospitals from multiple waves of COVID-19 is yet to be quantified. Here, we investigate the impact of different…
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Image creditFig 1. Kaplan-Meier analysis by transplant. by Linares et al., CC BY 4.0PLOS ONE A propensity score-matched analysis of mortality in solid organ transplant patients with COVID-19 compared to non-solid organ transplant patients
In the context of COVID-19 pandemic, we aimed to analyze the epidemiology, clinical characteristics, risk factors for mortality and impact…
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Image creditFig 1. Timeline of COVID19 in three pandemic hospitals. by Alkurt et al., CC BY 4.0PLOS ONE Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey
COVID-19 is a global threat with an increasing number of infections. Research on IgG seroprevalence among health care workers (HCWs) is…
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PLOS ONE Development of a multiplex Loop-Mediated Isothermal Amplification (LAMP) assay for on-site diagnosis of SARS CoV-2
A newly identified coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has spread rapidly from its…
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PLOS ONE Time series analysis of the demand for COVID-19 related chest imaging during the first wave of the SARS-CoV-2 pandemic: An explorative study
Objectives: The aim of this study was to investigate possible patterns of demand for chest imaging during the first wave of the SARS-CoV-2…
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PLOS ONE Tracking smell loss to identify healthcare workers with SARS-CoV-2 infection
Introduction: Healthcare workers (HCW) treating COVID-19 patients are at high risk for infection and may also spread infection through…
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Image creditFig 2. Crystal structure of the SR31-RBD complex. by Yao et al., CC BY 4.0PLOS Pathogens A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2
A key step to the SARS-CoV-2 infection is the attachment of its Spike receptor-binding domain (S RBD) to the host receptor ACE2.…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public DomainPLOS ONE Use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers associated with lower risk of COVID-19 in household contacts
Background: Use of angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) has been hypothesized to affect…
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PLOS Computational Biology Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action
Repurposed drugs that are safe and immediately available constitute a first line of defense against new viral infections. Despite limited…
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Image creditFig 1. β2-m levels in Covid-19 on admission to the hospital. by Conca et al., CC BY 4.0PLOS ONE Serum β2-microglobulin levels in Coronavirus disease 2019 (Covid-19): Another prognosticator of disease severity?
β2-microglobulin (β2-m), a 11.8 kDa protein, pairs non-covalently with the α3 domain of the major histocompatibility class (MHC) I α-chain…
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PLOS ONE Knowledge and practice of clients on preventive measures of COVID-19 pandemic among governmental health facilities in South Wollo, Ethiopia: A facility-based cross-sectional study
Introduction: Coronavirus-19 is a global health challenge and need an immediate action. Thus, understanding client’s knowledge about…
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PLOS ONE Assessing sub-regional-specific strengths of healthcare systems associated with COVID-19 prevalence, deaths and recoveries in Africa
Introduction: The coronavirus 2019 (COVID-19) has overwhelmed the health systems of several countries, particularly those within the…
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PLOS Computational Biology Estimating the cumulative incidence of SARS-CoV-2 with imperfect serological tests: Exploiting cutoff-free approaches
Large-scale serological testing in the population is essential to determine the true extent of the current SARS-CoV-2 pandemic.…
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PLOS ONE Myocardial injury in hospitalized patients with COVID-19 infection—Risk factors and outcomes
Myocardial injury in hospitalized patients is associated with poor prognosis. This study aimed to evaluate risk factors for myocardial…
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PLOS ONE Evaluation of sample pooling for screening of SARS CoV-2
Background: The coronavirus disease 2019 (COVID-19) pandemic has revealed the global public health importance of robust diagnostic testing.…
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PLOS Pathogens Breadth and function of antibody response to acute SARS-CoV-2 infection in humans
Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) have been analysed in three COVID-19…
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Image creditFig 1. Experimental timeline. by Braun et al., CC BY 4.0PLOS Pathogens Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck
The evolutionary mechanisms by which SARS-CoV-2 viruses adapt to mammalian hosts and, potentially, undergo antigenic evolution depend on…
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PLOS ONE CoViD-19, learning from the past: A wavelet and cross-correlation analysis of the epidemic dynamics looking to emergency calls and Twitter trends in Italian Lombardy region
The first case of Coronavirus Disease 2019 in Italy was detected on February the 20th in Lombardy region. Since that date, Lombardy has…
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Image creditFig 1. Results of Ewing’s autonomic battery. by Townsend et al., CC BY 4.0PLOS ONE Fatigue following COVID-19 infection is not associated with autonomic dysfunction
Background: The long-term clinical and physiological consequences of COVID-19 infection remain unclear. While fatigue has emerged as a…
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PLOS ONE Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa
Background: Inequality is rife throughout South Africa. The first wave of COVID-19 may have affected people in lower socioeconomic groups…
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Image creditFig 1. The 102 Chinese cities selected in the study. by Chong et al., CC BY 4.0PLOS Neglected Tropical Diseases Limited role for meteorological factors on the variability in COVID-19 incidence: A retrospective study of 102 Chinese cities
While many studies have focused on identifying the association between meteorological factors and the activity of COVID-19, we argue that…
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Image creditFig 1. The four stages of the viral infection of a cell in the model. by Vafadar et al., CC BY 4.0PLOS ONE Competitive exclusion during co-infection as a strategy to prevent the spread of a virus: A computational perspective
Inspired by the competition exclusion principle, this work aims at providing a computational framework to explore the theoretical…
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PLOS ONE Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation: Mass seroepidemiological screening in Castiglione d’Adda, Italy
Castiglione D’Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome…
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Image creditFig 1. Displaceable probe LAMP to detect SARS-CoV-2. by Yaren et al., CC BY 4.0PLOS ONE Ultra-rapid detection of SARS-CoV-2 in public workspace environments
Managing the pandemic caused by SARS-CoV-2 requires new capabilities in testing, including the possibility of identifying, in minutes,…
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Image creditFig 2. Imbalance data handling process. by Osman et al., CC BY 4.0PLOS ONE SOM-LWL method for identification of COVID-19 on chest X-rays
The outbreak of coronavirus disease 2019 (COVID-19) has had an immense impact on world health and daily life in many countries. Sturdy…
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PLOS ONE Association of SARS-CoV-2 viral load at admission with in-hospital acute kidney injury: A retrospective cohort study
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated Coronavirus Disease 2019 (COVID-19) is a public…
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PLOS ONE Comparative analysis of ACE2 protein expression in rodent, non-human primate, and human respiratory tract at baseline and after injury: A conundrum for COVID-19 pathogenesis
Angiotensin converting enzyme 2 (ACE2) is the putative functional receptor for severe acute respiratory syndrome coronavirus 2…
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PLOS ONE Saliva as a testing specimen with or without pooling for SARS-CoV-2 detection by multiplex RT-PCR test
Background: Sensitive and high throughput molecular detection assays are essential during the coronavirus disease 2019 (COVID-19) pandemic,…
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Image creditFig 1. Flowchart of the study design. by Flieder et al., CC BY 4.0PLOS ONE Retrospective analysis of 426 donors of a convalescent collective after mild COVID-19
Background: The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has…
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Image creditFig 1. Flow cytometry gating strategy of microparticles (MPs). by Zahran et al., CC BY 4.0PLOS ONE Circulating microparticles and activated platelets as novel prognostic biomarkers in COVID-19; relation to cancer
Background and aim: The study aimed to determine whether the MPs levels and platelet activation are affected by the COVID-19 infection in…
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PLOS ONE SARS-CoV-2 viral shedding characteristics and potential evidence for the priority for faecal specimen testing in diagnosis
This study aimed to identify the specimen type that has high positivity and its proper sampling time for severe acute respiratory syndrome…
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PLOS ONE Validation of the STANDARD Q COVID-19 antigen test in Vojvodina, Serbia
Background: Since COVID-19 pandemic is a global crisis, tests with high sensitivity and specificity are crucial for the identification and…
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PLOS ONE A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19
Gautret and colleagues reported the results of a non-randomised case series which examined the effects of hydroxychloroquine and…
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Image creditFig 2. A non-adherence tree (NAT). by Edifor et al., CC BY 4.0PLOS ONE Non-Adherence Tree Analysis (NATA)—An adherence improvement framework: A COVID-19 case study
Poor medication adherence is a global phenomenon that has received a significant amount of research attention yet remains largely…
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PLOS ONE Effects of public health interventions on the epidemiological spread during the first wave of the COVID-19 outbreak in Thailand
A novel infectious respiratory disease was recognized in Wuhan (Hubei Province, China) in December 2019. In February 2020, the disease was…
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Image creditFig 2. Venn diagram of overlapping symptoms. by Ruíz-Quiñonez et al., CC BY 4.0PLOS ONE Features of patients that died for COVID-19 in a hospital in the south of Mexico: A observational cohort study
Background: Due to the wide spread of SARS-CoV2 around the world, the risk of death in individuals with metabolic comorbidities has…
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Image creditFig 3. Numerical solutions for optimal control. by Gudara et al., CC BY 4.0PLOS ONE A control theory approach to optimal pandemic mitigation
In the framework of homogeneous susceptible-infected-recovered (SIR) models, we use a control theory approach to identify optimal pandemic…
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PLOS ONE Probabilistic analysis of COVID-19 patients’ individual length of stay in Swiss intensive care units
Rationale: The COVID-19 pandemic induces considerable strain on intensive care unit resources. Objectives: We aim to provide early…
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PLOS ONE Observational study of haloperidol in hospitalized patients with COVID-19
Background: Haloperidol, a widely used antipsychotic, has been suggested as potentially useful for patients with COVID-19 on the grounds of…
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Image creditFig 1. Awareness of study participants towards symptoms of COVID-19, 2020. by Gebretsadik et al., CC BY 4.0PLOS ONE Knowledge, attitude, practice towards COVID-19 pandemic and its prevalence among hospital visitors at Ataye district hospital, Northeast Ethiopia
Background: Coronavirus disease 19 (COVID-19) is currently a global health threat and public health emergency of international concern.…
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PLOS ONE Knowledge, attitude and practice towards COVID-19 among health professionals in Ethiopia: A systematic review and meta-analysis
Background: The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a global pandemic on 11th March, 2020. In…
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Image creditFig 4. Vascular complications in the liver. by Spogis et al., CC BY 4.0PLOS ONE Sonographic findings in coronavirus disease-19 associated liver damage
Purpose: This study was conducted to evaluate the role of liver sonography in patients with coronavirus disease 2019 (COVID-19) and…
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Image creditFig 2. 30-days Kaplan-Meier survival curves. by Díez-Manglano et al., CC BY 4.0PLOS ONE Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry
Aim: To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers…
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PLOS ONE Validation of two severity scores as predictors for outcome in Coronavirus Disease 2019 (COVID-19)
Background: An established objective and standardized reporting of clinical severity and disease progression in COVID-19 is still not…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID-RML, CC-0 Public Domain
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Image creditFig 1. SARS-CoV-2 entry mechanisms. by Murgolo et al., CC BY 4.0PLOS Pathogens SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development
Since the initial report of the novel Coronavirus Disease 2019 (COVID-19) emanating from Wuhan, China, Severe Acute Respiratory Syndrome…
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PLOS ONE Evidence and magnitude of the effects of meteorological changes on SARS-CoV-2 transmission
Importance: Intensity and duration of the COVID-19 pandemic, and planning required to balance concerns of saving lives and avoiding…
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Image creditFig 2. Under-counting of deaths per age groups. by Beatriz Seoane, CC BY 4.0PLOS ONE A scaling approach to estimate the age-dependent COVID-19 infection fatality ratio from incomplete data
SARS-CoV-2 has disrupted the life of billions of people around the world since the first outbreak was officially declared in China at the…
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PLOS ONE Insufficient social distancing may contribute to COVID-19 outbreak: The case of Ijuí city in Brazil
The coronavirus disease that emerged in 2019 (COVID-19) is highly contagious and has given way to a global pandemic. A present COVID-19…
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Image creditFig 2. Determination of IC50. by Morokutti-Kurz, CC BY 4.0PLOS ONE Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro
In the absence of a vaccine and other effective prophylactic or therapeutic countermeasures the severe acute respiratory syndrome-related…
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PLOS ONE The basic reproduction number can be accurately estimated within 14 days after societal lockdown: The early stage of the COVID-19 epidemic in Denmark
Objective: Early identification of the basic reproduction number (BRN) is imperative to political decision making during an epidemic. In…
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Image creditFig 5. Begg’s funnel plot for publication bias. by Fathi et al., CC BY 4.0
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Image creditFig 1. Study flow and outcomes. by Ferreira et al., CC BY 4.0
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Image creditNovel Coronavirus SARS-CoV-2 National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public Domain
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Image creditFig 2. Distribution of symptoms among the 447 symptomatic COVID-19 cases. by Al-Rifai et al., CC BY 4.0PLOS ONE Epidemiological characterization of symptomatic and asymptomatic COVID-19 cases and positivity in subsequent RT-PCR tests in the United Arab Emirates
The coronavirus disease 2019 (COVID-19) cases could be symptomatic or asymptomatic. We (1) characterized and analyzed data collected from…
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PLOS ONE Early detection of neutralizing antibodies against SARS-CoV-2 in COVID-19 patients in Thailand
Background: The presence of neutralizing antibodies (NAbs) is an indicator of protective immunity for most viral infections. A newly…
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PLOS Computational Biology The role of children in the spread of COVID-19: Using household data from Bnei Brak, Israel, to estimate the relative susceptibility and infectivity of children
One of the significant unanswered questions about COVID-19 epidemiology relates to the role of children in transmission. This study uses…
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PLOS ONE Evaluating the effect of Chinese control measures on COVID-19 via temporal reproduction number estimation
Control measures are necessary to contain the spread of serious infectious diseases such as COVID-19, especially in its early stage. We…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public DomainPLOS ONE Stakeholders perspective of, and experience with contact tracing for COVID-19 in Ghana: A qualitative study among contact tracers, supervisors, and contacts
Background: Ghana confirmed the first two cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) infection on 12th March…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases-Rocky Mountain Laboratories, NIH, CC-0 Public DomainPLOS ONE Prevalence and risk indicators of first-wave COVID-19 among oral health-care workers: A French epidemiological survey
Background: Previous studies have highlighted the increased risk of contracting the COVID-19 for health-care workers and suggest that oral…
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PLOS ONE Spatial pattern of COVID-19 deaths and infections in small areas of Brazil
As of mid-August 2020, Brazil was the country with the second-highest number of cases and deaths by the COVID-19 pandemic, but with large…
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Image creditFig 1. PRISMA flow diagram. by Chang et al., CC BY 4.0PLOS ONE COVID-19 ICU and mechanical ventilation patient characteristics and outcomes—A systematic review and meta-analysis
Background: Insight into COVID-19 intensive care unit (ICU) patient characteristics, rates and risks of invasive mechanical ventilation…
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PLOS ONE Association of mortality and aspirin prescription for COVID-19 patients at the Veterans Health Administration
There is growing evidence that thrombotic and inflammatory pathways contribute to the severity of COVID-19. Common medications such as…
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PLOS ONE Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae
Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-2, the causative agent of the COVID-19 pandemic.…
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PLOS ONE Cardiovascular sequalae in uncomplicated COVID-19 survivors
Background: A high proportion of COVID-19 patients were reported to have cardiac involvements. Data pertaining to cardiac sequalae is of…
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Image creditFig 2. Factor associated to Covid 19 diseases. by Schönfeld et al., CC BY 4.0PLOS ONE Clinical presentation and outcomes of the first patients with COVID-19 in Argentina: Results of 207079 cases from a national database
Background: There is limited evidence on the clinical characteristics of SARS-CoV-2 infection in Latin America. We present findings from a…
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PLOS Pathogens Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors
The interactions between antibodies, SARS-CoV-2 and immune cells contribute to the pathogenesis of COVID-19 and protective immunity. To…
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PLOS ONE A new perspective from time use research on the effects of social restrictions on COVID-19 behavioral infection risk
We present findings from three waves of a population-representative, UK time-use diary survey conducted both pre- and in real time during…
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PLOS ONE A robust pooled testing approach to expand COVID-19 screening capacity
Limited testing capacity for COVID-19 has hampered the pandemic response. Pooling is a testing method wherein samples from specimens…
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Image creditFig 2. Kaplan-Meier survival curves. by Casas-Aparicio et al., CC BY 4.0PLOS ONE Acute kidney injury in patients with severe COVID-19 in Mexico
Introduction: Some patients with COVID-19 pneumonia present systemic disease involving multiple systems. There is limited information about…
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PLOS ONE Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents
COVID-19 has had a substantial impact on clinical care and lifestyles globally. The State of Michigan reports over 80,000 positive…
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PLOS ONE Effectiveness of mid-regional pro-adrenomedullin (MR-proADM) as prognostic marker in COVID-19 critically ill patients: An observational prospective study
Objective: To test the effectiveness of mid-regional pro-adrenomedullin (MR-proADM) in comparison to C-reactive protein (CRP),…
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Image creditFig 1. Undocumented COVID-19 cases. by Noh et al., CC BY 4.0PLOS ONE Estimation of the fraction of COVID-19 infected people in U.S. states and countries worldwide
Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, daily counts of confirmed cases and deaths have been publicly…
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PLOS ONE Microvascular flow alterations in critically ill COVID-19 patients: A prospective study
Background: Data on microcirculatory pattern of COVID-19 critically ill patients are scarce. The objective was to compare sublingual…
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Image creditFig 1. MoCA, MMSE and HRSD total scores. by Alemanno et al., CC BY 4.0PLOS ONE COVID-19 cognitive deficits after respiratory assistance in the subacute phase: A COVID-rehabilitation unit experience
Introduction: COVID-19 complications can include neurological, psychiatric, psychological, and psychosocial impairments. Little is known on…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests
We examined the usefulness of five COVID-19 antibody detection tests using 114 serum samples at various time points from 34 Japanese…
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Image creditFig 2. Dendrogram and heatmap of the drug-disease network. by Fiscon et al., CC BY 4.0PLOS Computational Biology SAveRUNNER: A network-based algorithm for drug repurposing and its application to COVID-19
The novelty of new human coronavirus COVID-19/SARS-CoV-2 and the lack of effective drugs and vaccines gave rise to a wide variety of…
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PLOS ONE Airborne aerosol olfactory deposition contributes to anosmia in COVID-19
Introduction: Olfactory dysfunction (OD) affects a majority of COVID-19 patients, is atypical in duration and recovery, and is associated…
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PLOS ONE Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco
Since December 2019, the coronavirus disease (COVID-19) pandemic has catapulted the world into a marked health crisis, with over 29…
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Image creditFig 4. Large-scale molecular screening of SARS-CoV-2 with swab pooling. by Christoff et al., CC BY 4.0PLOS ONE Swab pooling: A new method for large-scale RT-qPCR screening of SARS-CoV-2 avoiding sample dilution
To minimize sample dilution effect on SARS-CoV-2 pool testing, we assessed analytical and diagnostic performance of a new methodology,…
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PLOS Computational Biology Dynamics of COVID-19 under social distancing measures are driven by transmission network structure
In the absence of pharmaceutical interventions, social distancing is being used worldwide to curb the spread of COVID-19. The impact of…
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PLOS ONE Covid-19 in outpatients—Is fever a useful indicator for SARS-CoV-2 infection?
Objective: Understanding mild to moderate symptoms of coronavirus disease 2019 (Covid-19) is important in order to identify active cases…
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Image creditFig 2. Bar graph. by et al. Olivas-Martínez, CC BY 4.0PLOS ONE In-hospital mortality from severe COVID-19 in a tertiary care center in Mexico City; causes of death, risk factors and the impact of hospital saturation
Background: As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has remained in Latin America, Mexico has become…
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PLOS ONE Urban-rural differences in COVID-19 exposures and outcomes in the South: A preliminary analysis of South Carolina
As the COVID-19 pandemic moved beyond the initial heavily impacted and urbanized Northeast region of the United States, hotspots of cases…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC0 Public DomainPLOS Neglected Tropical Diseases China’s COVID-19 response for the protection of rural communities
…
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Image creditNovel Coronavirus SARS-CoV-2 NIAID/NIH, CC-0PLOS ONE Machine learning model for predicting severity prognosis in patients infected with COVID-19: Study protocol from COVID-AI Brasil
The new coronavirus, which began to be called SARS-CoV-2, is a single-stranded RNA beta coronavirus, initially identified in Wuhan (Hubei…
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PLOS ONE A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease
Effective SARS-CoV-2 antiviral drugs are desperately needed. The SARS-CoV-2 main protease (Mpro) appears as an attractive target for drug…
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PLOS Pathogens Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab
The current pandemic emergence of novel coronavirus disease (COVID-19) poses a relevant threat to global health. SARS-CoV-2 infection is…
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PLOS Computational Biology Assessing the potential impact of transmission during prolonged viral shedding on the effect of lockdown relaxation on COVID-19
A key parameter in epidemiological modeling which characterizes the spread of an infectious disease is the generation time, or more…
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PLOS ONE Early risk markers for severe clinical course and fatal outcome in German patients with COVID-19
Background: Some patients with Corona Virus Disease 2019 (COVID-19) develop a severe clinical course with acute respiratory distress…
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PLOS ONE High SARS-CoV-2 load in the nasopharynx of patients with a mild form of COVID-19 is associated with clinical deterioration regardless of the hydroxychloroquine administration
Because of the constantly growing numbers of COVID-19 infections and deaths, attempts were undertaken to find drugs with anti-SARS-CoV-2…
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PLOS ONE The differential impact of pediatric COVID-19 between high-income countries and low- and middle-income countries: A systematic review of fatality and ICU admission in children worldwide
Background: The overall global impact of COVID-19 in children and regional variability in pediatric outcomes are presently unknown.…
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PLOS ONE Effect of timing of implementation of containment measures on Covid-19 epidemic. The case of the first wave in Italy
There is evidence that adoption of non-pharmaceutical containment measures (NPMs) may have had a major impact on Covid-19 epidemic…
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PLOS ONE Evaluation of the practicability of a finger-stick whole-blood SARS-Cov-2 self-test adapted for the general population
Background: COVID-19 (COronaVIrus Disease 2019) is an infectious respiratory disease caused by the novel SARS-CoV-2 virus. Point of Care…
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PLOS ONE High-dose corticosteroid pulse therapy increases the survival rate in COVID-19 patients at risk of hyper-inflammatory response
Objective: Test whether high dose corticosteroid pulse therapy (HDCPT) with either methylprednisolone or dexamethasone is associated with…
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PLOS ONE Epidemiology of COVID-19 vs. influenza: Differential failure of COVID-19 mitigation among Hispanics, Cook County Health, Illinois
Background: During the early phases of the COVID-19 pandemic in the U.S., African-American or Hispanic communities were disproportionately…
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PLOS ONE SARS-CoV-2 infection in asymptomatic healthcare workers at a clinic in Chile
Asymptomatic SARS-CoV-2 infection of healthcare workers (HCWs) has been reported as a key player in the nosocomial spreading of COVID-19.…
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PLOS ONE Risk factors for mortality of coronavirus disease-2019 (COVID-19) patients in two centers of Hubei province, China: A retrospective analysis
Purpose: Since the outbreak in late December 2019 in Wuhan, China, coronavirus disease-2019 (COVID-19) has become a global pandemic. We…
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PLOS ONE Factors associated with admission to intensive care units in COVID-19 patients in Lyon-France
Introduction: A new respiratory virus, SARS-CoV-2, has emerged and spread worldwide since late 2019. This study aims at analysing clinical…
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PLOS ONE First report on prevalence of SARS-CoV-2 infection among health-care workers in Nicaragua
The Nicaraguan COVID-19 situation is exceptional for Central America. The government restricts testing and testing supplies, and the true…
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PLOS ONE Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study
Antibody responses are important in the control of viral respiratory infection in the human host. What is not clear for SARS-CoV-2 is how…
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PLOS ONE Effects of short-term travel on COVID-19 spread: A novel SEIR model and case study in Minnesota
The novel coronavirus responsible for COVID-19 was first identified in Hubei Province, China in December, 2019. Within a matter of months…
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PLOS ONE The independent factors associated with oxygen therapy in COVID-19 patients under 65 years old
Background: The number of hospitalized young coronavirus disease 2019 (COVID-19) patients has increased significantly. However, specific…
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PLOS ONE COVID-19 prevalence and predictors in United States adults during peak stay-at-home orders
Background: Early recognition of COVID-19 cases is essential for effective public health measures aimed at isolation of individuals…
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PLOS ONE Rapid conversion of an in-patient hospital unit to accommodate COVID-19: An interdisciplinary human factors, ethnography, and infection prevention and control approach
Background: In response to the Coronavirus disease-19 (COVID-19) pandemic, in-patient units in hospitals around the world have altered…
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PLOS ONE Incidence and characterization of acute pulmonary embolism in patients with SARS-CoV-2 pneumonia: A multicenter Italian experience
Background and aims: Several studies reported a high incidence of pulmonary embolism (PE) among patients with severe acute respiratory…
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PLOS ONE Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study
Objectives: We aimed to derive and validate a triage tool, based on clinical assessment alone, for predicting adverse outcome in acutely…
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PLOS ONE Development and validation of a clinical risk score to predict the risk of SARS-CoV-2 infection from administrative data: A population-based cohort study from Italy
Background: The novel coronavirus (SARS-CoV-2) pandemic spread rapidly worldwide increasing exponentially in Italy. To date, there is lack…
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PLOS ONE Characteristics and predicting factors of Corona Virus Disease-2019 (COVID-19) among healthcare providers in a developing country
A limited number of publications have identified risk factors for Corona Virus Disease 2019 (COVID-19) among Healthcare Providers (HCPs).…
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PLOS ONE Converting the maybes: Crucial for a successful COVID-19 vaccination strategy
Background: Broad community acceptance of a COVID-19 vaccination will be critical for effectively halting the spread of the virus. In this…
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PLOS ONE Medical resources and coronavirus disease (COVID-19) mortality rate: Evidence and implications from Hubei province in China
In light of the ongoing coronavirus disease (COVID-19) pandemic, this study aims to examine the relationship between the availability of…
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PLOS ONE Impact of SARS-CoV-2 pandemic among health care workers in a secondary teaching hospital in Spain
Background: The COVID-19 pandemic has posed a huge challenge to healthcare systems and their personnel worldwide. The study of the impact…
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PLOS ONE High-risk chest radiographic features associated with COVID-19 disease severity
Objectives: High-risk CXR features in COVID-19 are not clearly defined. We aimed to identify CXR features that correlate with severe…
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PLOS ONE Health conditions of potential risk for severe Covid-19 in institutionalized elderly people
The objective of this study was to identify the health conditions considered potential risk factors for severe Covid-19 and analyze its…
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PLOS ONE Clinical and radiological findings of adult hospitalized patients with community-acquired pneumonia from SARS-CoV-2 and endemic human coronaviruses
Endemic human coronaviruses (HCoVs) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are members of the family…
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PLOS Pathogens Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina
We report the emergency development and application of a robust serologic test to evaluate acute and convalescent antibody responses to…
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PLOS ONE Earliest detection to date of SARS-CoV-2 in Florida: Identification together with influenza virus on the main entry door of a university building, February 2020
In February and March, 2020, environmental surface swab samples were collected from the handle of the main entry door of a major…
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PLOS ONE Sex differences in susceptibility, severity, and outcomes of coronavirus disease 2019: Cross-sectional analysis from a diverse US metropolitan area
Introduction: Sex is increasingly recognized as an important factor in the epidemiology and outcome of many diseases. This also appears to…
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PLOS ONE Impact of first wave of SARS-CoV-2 infection in patients with Systemic Lupus Erythematosus: Weighting the risk of infection and flare
Introduction: The aim of this study was to investigate the incidence and clinical presentation of SARS-CoV-2 infections in a Systemic Lupus…
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PLOS ONE Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19
Background: Treatment of severely ill COVID-19 patients requires simultaneous management of oxygenation and inflammation without…
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PLOS ONE Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2)
Drug repurposing for COVID-19 has several potential benefits including shorter development time, reduced costs and regulatory support for…
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PLOS Neglected Tropical Diseases COVID-19, leprosy, and neutrophils
Coronavirus Disease 2019 (COVID-19), a disease caused by the betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2),…
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PLOS Computational Biology The value of decreasing the duration of the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
Finding medications or vaccines that may decrease the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
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PLOS Neglected Tropical Diseases Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
Wuhan City (WH) in China was the first place to report COVID-19 in the world and the outbreak of COVID-19 was controlled in March of 2020…
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PLOS ONE Therapeutic plasma exchange for coronavirus disease-2019 triggered cytokine release syndrome; a retrospective propensity matched control study
Background: Cytokine release syndrome (CRS) plays a pivotal role in the pathophysiology and progression of Coronavirus disease-2019…
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PLOS ONE A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients
Purpose: COVID-19 pandemic has multifaceted presentations with rising evidence of immune-mediated mechanisms underplay. We sought to…
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PLOS ONE Mortality and other outcomes of patients with coronavirus disease pneumonia admitted to the emergency department: A prospective observational Brazilian study
Background: The first cases of coronavirus disease (COVID-19) in Brazil were diagnosed in February 2020. Our Emergency Department (ED) was…
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PLOS Neglected Tropical Diseases Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in China
Background: Until now, no antiviral treatment has been proven to be effective for the coronavirus disease 2019 (COVID-19). The timing of…
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PLOS ONE Optimal periodic closure for minimizing risk in emerging disease outbreaks
Without vaccines and treatments, societies must rely on non-pharmaceutical intervention strategies to control the spread of emerging…
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PLOS ONE The efficacy and safety of hydroxychloroquine for COVID-19 prophylaxis: A systematic review and meta-analysis of randomized trials
Background: Populations such as healthcare workers (HCW) that are unable to practice physical distancing are at high risk of acquiring…
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PLOS ONE Covert cases of Severe Acute Respiratory Syndrome Coronavirus 2: An obscure but present danger in regions endemic for Dengue and Chikungunya viruses
Background: The impact of SARS-CoV-2 in regions endemic for both Dengue and Chikungunya is still not fully understood. Considering that…
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PLOS ONE The chronic kidney disease and acute kidney injury involvement in COVID-19 pandemic: A systematic review and meta-analysis
Background: Currently, the SARS-CoV-2 promptly spread across China and around the world. However, there are controversies about whether…
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PLOS ONE The association of chest radiographic findings and severity scoring with clinical outcomes in patients with COVID-19 presenting to the emergency department of a tertiary care hospital in Pakistan
Introduction: While chest x-rays (CXRs) represent a cost-effective imaging modality for developing countries like Pakistan, their utility…
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PLOS ONE Propagation of viral bioaerosols indoors
Here we look into the spread of aerosols indoors that may potentially carry viruses. Many viruses, including the novel SARS-CoV-2, are…
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PLOS Neglected Tropical Diseases Zinc against COVID-19? Symptom surveillance and deficiency risk groups
A wide variety of symptoms is associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and these symptoms…
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PLOS Pathogens The role of Neuropilin-1 in COVID-19
Neuropilin-1 (NRP-1), a member of a family of signaling proteins, was shown to serve as an entry factor and potentiate SARS Coronavirus 2…
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PLOS ONE The role of CPAP as a potential bridge to invasive ventilation and as a ceiling-of-care for patients hospitalized with Covid-19—An observational study
Background: Continuous positive airway pressure (CPAP) ventilation may be used as a potential bridge to invasive mechanical ventilation…
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PLOS ONE The risk factors for mortality of diabetic patients with severe COVID-19: A retrospective study of 167 severe COVID-19 cases in Wuhan
Diabetes is one of the most common comorbidities in adult patients with coronavirus disease 2019 (COVID-19). This study aimed to analyze…
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PLOS ONE Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis
Introduction: Coronavirus disease 2019 (COVID-19) appeared in China in December 2019 and has spread around the world. High Interleukin-6…
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PLOS ONE Spatiotemporal spread pattern of the COVID-19 cases in China
The COVID-19 pandemic is currently spreading widely around the world, causing huge threats to public safety and global society. This study…
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PLOS ONE SARS-CoV-2 PCR cycle threshold at hospital admission associated with patient mortality
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cycle threshold (Ct) has been suggested as an approximate measure…
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PLOS ONE Antibody response to SARS-CoV-2 infection in humans: A systematic review
Background: Progress in characterising the humoral immune response to Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) has been rapid but…
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PLOS ONE SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsets
Clinical manifestations of SARS-CoV-2 infection range from mild to critically severe. The aim of the study was to highlight the…
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PLOS ONE Severity of COVID-19 at elevated exposure to perfluorinated alkylates
Background: The course of coronavirus disease 2019 (COVID-19) seems to be aggravated by air pollution, and some industrial chemicals, such…
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PLOS ONE The use of methylprednisolone in COVID-19 patients: A propensity score matched retrospective cohort study
Purpose: To evaluate the efficacy and safety of methylprednisolone in treating the coronavirus disease 2019 (COVID-19) patients. Methods: A…
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PLOS Medicine Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis
Background: Numerous clinical trials and observational studies have investigated various pharmacological agents as potential treatment for…
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PLOS ONE Safety, tolerability, and outcomes of losartan use in patients hospitalized with SARS-CoV-2 infection: A feasibility study
Background: Retrospective studies on the use of Renin-Angiotensin-Aldosterone System blockade in patients with Coronavirus Disease 2019…
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PLOS ONE Time to recovery and its predictors among adults hospitalized with COVID-19: A prospective cohort study in Ethiopia
Background: Various factors may determine the duration of viral shedding (the time from infection to viral RNA-negative conversion or…
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PLOS ONE Coronary calcium scoring assessed on native screening chest CT imaging as predictor for outcome in COVID-19: An analysis of a hospitalized German cohort
Background: Since the outbreak of the COVID-19 pandemic, a number of risk factors for a poor outcome have been identified. Thereby,…
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PLOS Computational Biology The COVID-19 outbreak in Sichuan, China: Epidemiology and impact of interventions
In January 2020, a COVID-19 outbreak was detected in Sichuan Province of China. Six weeks later, the outbreak was successfully contained.…
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PLOS ONE Epidemiology, clinical characteristics, household transmission, and lethality of severe acute respiratory syndrome coronavirus-2 infection among healthcare workers in Ontario, Canada
Introduction: Protecting healthcare workers (HCWs) from Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a priority to…
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PLOS ONE Seroprevalence of SARS-CoV-2 IgG specific antibodies among healthcare workers in the Northern Metropolitan Area of Barcelona, Spain, after the first pandemic wave
Background: The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) around the world has caused a global pandemic,…
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PLOS ONE COVID-19 disease—Temporal analyses of complete blood count parameters over course of illness, and relationship to patient demographics and management outcomes in survivors and non-survivors: A longitudinal descriptive cohort study
Background: Detailed temporal analyses of complete (full) blood count (CBC) parameters, their evolution and relationship to patient age,…
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PLOS ONE High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy
Introduction: A large proportion of patients with COVID-19 develop acute kidney injury (AKI). While the most severe of these cases require…
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PLOS ONE Cardiac arrhythmias in hospitalized patients with COVID-19: A prospective observational study in the western United States
Arrhythmias have been reported frequently in COVID-19 patients, but the incidence and nature have not been well characterized. Patients…
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PLOS ONE Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
Introduction: Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim…
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PLOS ONE Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
Background: A higher incidence of thrombotic events, mainly pulmonary embolism (PE), has been reported in hospitalized patients with…
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PLOS ONE Estimation of the incubation period of COVID-19 in Vietnam
Objective: To estimate the incubation period of Vietnamese confirmed COVID-19 cases. Methods: Only confirmed COVID-19 cases who are…
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PLOS ONE Calcification of the thoracic aorta on low-dose chest CT predicts severe COVID-19
Background: Cardiovascular comorbidity anticipates poor prognosis of SARS-CoV-2 disease (COVID-19) and correlates with the systemic…
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PLOS ONE A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidates
We compare and contrast the expected duration and number of infections and deaths averted among several designs for clinical trials of…
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PLOS Neglected Tropical Diseases Mild manifestations of COVID-19 in healthcare workers
Medical staff treating Coronavirus Disease 2019 (COVID-19) patients are at high risk for exposure to Severe Acute Respiratory Syndrome…
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PLOS ONE A spatial-temporal description of the SARS-CoV-2 infections in Indonesia during the first six months of outbreak
Background: Since the first cases reported in Wuhan, China, in December 2019, the Severe Acute Respiratory Syndrome Coronavirus 2…
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PLOS ONE COVID-19 pandemic in Djibouti: Epidemiology and the response strategy followed to contain the virus during the first two months, 17 March to 16 May 2020
First cases of COVID-19 were reported from Wuhan, China, in December 2019, and it progressed rapidly. On 30 January, WHO declared the new…
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PLOS ONE Obesity and smoking as risk factors for invasive mechanical ventilation in COVID-19: A retrospective, observational cohort study
Purpose: To describe the trajectory of respiratory failure in COVID-19 and explore factors associated with risk of invasive mechanical…
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PLOS ONE Manufacturing of convalescent plasma of COVID-19 patients: Aspects of quality
The ongoing coronavirus disease 2019 (COVID-19) pandemic emerged in December 2019. Convalescent plasma represents a promising COVID-19…
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PLOS ONE Effects of voluntary event cancellation and school closure as countermeasures against COVID-19 outbreak in Japan
Background: To control the COVID-19 outbreak in Japan, sports and entertainment events were canceled and schools were closed throughout…
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PLOS ONE Evaluation of pool-based testing approaches to enable population-wide screening for COVID-19
Objective: Rapid testing is paramount during a pandemic to prevent continued viral spread and excess morbidity and mortality. This study…
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PLOS ONE Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia
Background: Angiotensin-converting enzyme 2 is the receptor that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses for…
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PLOS ONE A simplified SARS-CoV-2 detection protocol for research laboratories
Widespread testing is required to limit the current public health crisis caused by the COVID-19 pandemic. Multiple tests protocols have…
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PLOS ONE Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study
Objectives: To describe the clinical characteristics of patients infected with SARS-CoV-2 at Clinique Ngaliema, a public hospital, in…
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PLOS Neglected Tropical Diseases Understanding COVID-19 vaccine demand and hesitancy: A nationwide online survey in China
Background: This study attempts to understand coronavirus disease 2019 (COVID-19) vaccine demand and hesitancy by assessing the public’s…
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PLOS ONE Characteristics and outcomes of COVID-19 patients in New York City’s public hospital system
Background: New York City (NYC) bore the greatest burden of COVID-19 in the United States early in the pandemic. In this case series, we…
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PLOS ONE Clinical features and risk factors for severe inpatients with COVID-19: A retrospective study in China
Background: A worldwide outbreak of coronavirus disease (COVID-19), since 2019, has brought a disaster to people all over the world. Many…
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PLOS ONE Vulnerability of deep neural networks for detecting COVID-19 cases from chest X-ray images to universal adversarial attacks
Owing the epidemic of the novel coronavirus disease 2019 (COVID-19), chest X-ray computed tomography imaging is being used for effectively…
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PLOS ONE Coronavirus-induced coagulopathy during the course of disease
Background: A significant proportion of patients with coronavirus disease 19 (COVID-19) suffer from excessive coagulation activation and…
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PLOS ONE Pre-test probability for SARS-Cov-2-related infection score: The PARIS score
Introduction: In numerous countries, large population testing is impossible due to the limited availability of RT-PCR kits and CT-scans.…
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PLOS ONE Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka
Karnataka, a state in south India, reported its first case of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection on…
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PLOS ONE Prevalence and risk factors of disability and anxiety in a retrospective cohort of 432 survivors of Coronavirus Disease-2019 (Covid-19) from China
Objective: To estimate the prevalence of disability and anxiety in Covid-19 survivors at discharge from hospital and analyze relative risk…
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PLOS ONE An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19
As the SARS-CoV2 pandemic has progressed, there have been marked geographical differences in the pace and extent of its spread. We…
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PLOS ONE Outcomes of an intermediate respiratory care unit in the COVID-19 pandemic
Background: 15% of COVID-19 patients develop severe pneumonia. Non-invasive mechanical ventilation and high-flow nasal cannula can reduce…
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PLOS ONE Validation and repurposing of the MSL-COVID-19 score for prediction of severe COVID-19 using simple clinical predictors in a triage setting: The Nutri-CoV score
Background: During the COVID-19 pandemic, risk stratification has been used to decide patient eligibility for inpatient, critical and…
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PLOS ONE Glucocorticoids with low-dose anti-IL1 anakinra rescue in severe non-ICU COVID-19 infection: A cohort study
Background: The optimal treatment for patients with severe coronavirus-19 disease (COVID-19) and hyper-inflammation remains debated.…
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PLOS ONE Clinical outcomes and inflammatory marker levels in patients with Covid-19 and obesity at an inner-city safety net hospital
Objectives: Patients with Covid-19 and obesity have worse clinical outcomes which may be driven by increased inflammation. This study aimed…
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PLOS ONE Metabolic risk factors and risk of Covid-19: A systematic review and meta-analysis
Objective: Based on the epidemiologic findings of Covid-19 incidence; illness and mortality seem to be associated with metabolic risk…
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PLOS ONE Human agency and infection rates: Implications for social distancing during epidemics
Social distancing is an important measure in controlling epidemics. This paper presents a simple theoretical model focussed on the…
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PLOS ONE COVID-19: Spatial analysis of hospital case-fatality rate in France
When the population risk factors and reporting systems are similar, the assessment of the case-fatality (or lethality) rate (ratio of…
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PLOS ONE Clinical characteristics and outcomes of critically ill patients with COVID-19 admitted to an intensive care unit in London: A prospective observational cohort study
Background: Cohorts of severely ill patients with COVID-19 have been described in several countries around the globe, but to date there…
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PLOS ONE Coagulation profile of COVID-19 patients admitted to the ICU: An exploratory study
Background: Coagulation abnormalities in COVID-19 patients have not been addressed in depth. Objective: To perform a longitudinal…
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PLOS ONE Characteristics, comorbidities and survival analysis of young adults hospitalized with COVID-19 in New York City
This study reviewed 395 young adults, 18–35 year-old, admitted for COVID-19 to one of the eleven hospitals in New York City public health…
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PLOS ONE Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients
Background: The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its…
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PLOS ONE Correlation between hospitalized patients’ demographics, symptoms, comorbidities, and COVID-19 pandemic in Bahia, Brazil
In this paper, we provide a retrospective cohort study with patients that have been hospitalized for general or intensive care unit…
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PLOS ONE Safe contact tracing for COVID-19: A method without privacy breach using functional encryption techniques based-on spatio-temporal trajectory data
The COVID-19 pandemic has spread all over the globe. In the absence of a vaccine, a small number of countries have managed to control the…
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PLOS ONE Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection
Background: Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and…
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PLOS ONE Behavioral preventive measures and the use of medicines and herbal products among the public in response to Covid-19 in Bangladesh: A cross-sectional study
The present study was conducted to assess the behavioral preventive measures and the use of medicines and herbal foods/products among the…
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PLOS ONE Universal screening for SARS-CoV-2 infection among pregnant women at Elmhurst Hospital Center, Queens, New York
Background: Universal screening for SARS-CoV-2 infection on Labor and Delivery (L&D) units is a critical strategy to manage patient and…
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PLOS ONE Can the detection dog alert on COVID-19 positive persons by sniffing axillary sweat samples? A proof-of-concept study
The aim of this proof-of-concept study was to evaluate if trained dogs could discriminate between sweat samples from symptomatic COVID-19…
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PLOS ONE Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis
Background: Efficacy and safety of treatments for hospitalized COVID-19 are uncertain. We systematically reviewed efficacy and safety of…
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PLOS ONE Analyzing changes in respiratory rate to predict the risk of COVID-19 infection
COVID-19, the disease caused by the SARS-CoV-2 virus, can cause shortness of breath, lung damage, and impaired respiratory function.…
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PLOS ONE COVID-19 hospitalizations in Brazil’s Unified Health System (SUS)
Objective: To study the profile of hospitalizations due to COVID-19 in the Unified Health System (SUS) in Brazil and to identify factors…
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PLOS ONE Epidemiological profile of SARS-CoV-2 among selected regions in Ghana: A cross-sectional retrospective study
Background: Global cases of COVID-19 continue to rise, causing havoc to several economies. So far, Ghana has recorded 48,643 confirmed…
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PLOS ONE Impact of chronic liver disease upon admission on COVID-19 in-hospital mortality: Findings from COVOCA study
Background: Italy has been the first Western country to be heavily affected by the spread of SARS-COV-2 infection and among the pioneers of…
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PLOS ONE The local stability of a modified multi-strain SIR model for emerging viral strains
We study a novel multi-strain SIR epidemic model with selective immunity by vaccination. A newer strain is made to emerge in the…
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PLOS ONE Transmissibility of COVID-19 depends on the viral load around onset in adult and symptomatic patients
Objective: To investigate the relationship between viral load and secondary transmission in novel coronavirus disease 2019 (COVID-19).…
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PLOS ONE Severe acute kidney injury in COVID-19 patients is associated with in-hospital mortality
Although the lungs are major targets for COVID-19 invasion, other organs—such as the kidneys—are also affected. However, the renal…
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PLOS ONE COVID-19 mortality risk assessment: An international multi-center study
Timely identification of COVID-19 patients at high risk of mortality can significantly improve patient management and resource allocation…
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PLOS ONE COVID-MATCH65—A prospectively derived clinical decision rule for severe acute respiratory syndrome coronavirus 2
Objectives: We report on the key clinical predictors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and present…
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PLOS ONE Comparison of COVID-19 infections among healthcare workers and non-healthcare workers
Objectives: Healthcare workers face distinct occupational challenges that affect their personal health, especially during a pandemic. In…
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PLOS ONE On the authenticity of COVID-19 case figures
In this article, we study the applicability of Benford’s law and Zipf’s law to national COVID-19 case figures with the aim of establishing…
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PLOS ONE Community interventions in Low—And Middle-Income Countries to inform COVID-19 control implementation decisions in Kenya: A rapid systematic review
Globally, public health measures like face masks, hand hygiene and maintaining social distancing have been implemented to delay and reduce…
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PLOS Neglected Tropical Diseases Risk assessment and evaluation of China’s policy to prevent COVID-19 cases imported by plane
As of October 5, 2020, China has reported 2,921 cases imported from overseas. Assessing the effectiveness of China's current policies on…
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PLOS ONE Estimating individual risks of COVID-19-associated hospitalization and death using publicly available data
We describe a method to estimate individual risks of hospitalization and death attributable to non-household and household transmission of…
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PLOS ONE Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patients
Introduction: Progression of COVID-19 to severe disease and death is insufficiently understood. Objective: Summarize the prevalence of risk…
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PLOS ONE Initial estimates of COVID-19 infections in hospital workers in the United States during the first wave of pandemic
Objective: We estimated the number of hospital workers in the United States (US) that might be infected or die during the COVID-19 pandemic…
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PLOS ONE Comparison of the clinical manifestations between different age groups of patients with overseas imported COVID-19
The current study investigated the clinical manifestations and outcomes of different age groups of patients with overseas imported…
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PLOS ONE The lower COVID-19 related mortality and incidence rates in Eastern European countries are associated with delayed start of community circulation
Background: The purpose of this analysis was to assess the variations in COVID-19 related mortality in relation to the time differences in…
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PLOS ONE Principal component analysis of coronaviruses reveals their diversity and seasonal and pandemic potential
Coronaviruses and influenza viruses have similarities and differences. In order to comprehensively compare them, their genome sequencing…
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PLOS ONE Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19
Introduction: Greece is a country with limited spread of SARS-CoV-2 and cumulative infection attack rate of 0.12% (95% CI 0.06–0.26).…
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PLOS ONE Retinal changes in COVID-19 hospitalized cases
The main objective of this study was to evaluate the retinas of severely or critically ill COVID-19 patients during their hospital stay,…
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PLOS ONE Epidemiology, outcomes, and the use of intensive care unit resources of critically ill patients diagnosed with COVID-19 in Sao Paulo, Brazil: A cohort study
Background: The coronavirus disease (COVID-19) pandemic has brought significant challenges worldwide, with high mortality, increased use of…
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PLOS ONE Characteristics associated with COVID-19 or other respiratory viruses’ infections at a single-center emergency department
Background: Rapid identification of patients with high suspicion of COVID-19 will become a challenge with the co-circulation of multiple…
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PLOS ONE A multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with mild to moderate coronavirus disease 2019 (COVID-19)
Objective: In this study, we evaluated the efficacy of hydroxychloroquine (HCQ) against coronavirus disease 2019 (COVID-19) via a…
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PLOS ONE In silico immune infiltration profiling combined with functional enrichment analysis reveals a potential role for naïve B cells as a trigger for severe immune responses in the lungs of COVID-19 patients
COVID-19, caused by SARS-CoV-2, has rapidly spread to more than 160 countries worldwide since 2020. Despite tremendous efforts and…
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PLOS ONE Early predictive factors of progression from severe type to critical ill type in patients with Coronavirus Disease 2019: A retrospective cohort study
Background: The current worldwide pandemic of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, and…
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PLOS ONE Core warming of coronavirus disease 2019 (COVID-19) patients undergoing mechanical ventilation—A protocol for a randomized controlled pilot study
Background: Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is spreading rapidly across the globe, with little proven…
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PLOS Neglected Tropical Diseases SARS-CoV-2 lineage B.6 was the major contributor to early pandemic transmission in Malaysia
Malaysia had 10,219 confirmed cases of COVID-19 as of September 20, 2020. About 33% were associated with a Tablighi Jamaat religious mass…
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PLOS ONE Study on SARS-CoV-2 transmission and the effects of control measures in China
Objective: To reconstruct the transmission trajectory of SARS-CoV-2 and analyze the effects of control measures in China. Methods: Python…
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PLOS ONE Risk factors for predicting mortality of COVID-19 patients: A systematic review and meta-analysis
Background: Early and accurate prognosis prediction of the patients was urgently warranted due to the widespread popularity of COVID-19. We…
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PLOS ONE Characterisation of 22445 patients attending UK emergency departments with suspected COVID-19 infection: Observational cohort study
Background: Hospital emergency departments play a crucial role in the initial assessment and management of suspected COVID-19 infection.…
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PLOS ONE Biodistribution and serologic response in SARS-CoV-2 induced ARDS: A cohort study
Background: The viral load and tissue distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain important…
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PLOS ONE Deep-learning algorithms for the interpretation of chest radiographs to aid in the triage of COVID-19 patients: A multicenter retrospective study
The recent medical applications of deep-learning (DL) algorithms have demonstrated their clinical efficacy in improving speed and accuracy…
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PLOS ONE Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19
Purpose: In the management of COVID-19, knowledge is lacking on the frequency of secondary bacterial infections and on how empirical…
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PLOS ONE Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure
Purpose: The outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine…
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PLOS ONE Clinical characteristics and online mental health care of asymptomatic or mildly symptomatic patients with coronavirus disease 2019
Comparing to data in patients with severe coronavirus diseases 2019 (COVID-19), there are few studies on the prevalence anxiety and/or…
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PLOS ONE Diagnostic performance of chest computed tomography during the epidemic wave of COVID-19 varied as a function of time since the beginning of the confinement in France
Objective: To evaluate the diagnostic performance of the initial chest CT to diagnose COVID-19 related pneumonia in a French population of…
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PLOS ONE Comorbidity and clinical factors associated with COVID-19 critical illness and mortality at a large public hospital in New York City in the early phase of the pandemic (March-April 2020)
Background: Despite evidence of socio-demographic disparities in outcomes of COVID-19, little is known about characteristics and clinical…
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PLOS ONE ICU admissions and in-hospital deaths linked to COVID-19 in the Paris region are correlated with previously observed ambient temperature
The purpose of this ecological study was to explore the association of weather with severity indicators of coronavirus disease 2019…
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PLOS ONE Effectiveness of infection-containment measures on SARS-CoV-2 seroprevalence and circulation from May to July 2020, in Milan, Italy
Objective: Through a hospital-based SARS-CoV-2 molecular and serological screening, we evaluated the effectiveness of two months of…
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PLOS ONE Clinical characteristics of coronavirus disease 2019 (COVID-19) patients in Kuwait
This is a retrospective single-center study of 417 consecutive patients with coronavirus disease 2019 (COVID-19) admitted to Jaber…
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PLOS ONE C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19
Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease…
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PLOS ONE Performance of serum apolipoprotein-A1 as a sentinel of Covid-19
Background: Since 1920, a decrease in serum cholesterol has been identified as a marker of severe pneumonia. We have assessed the…
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PLOS ONE Antibody profiling and prevalence in US patients during the SARS-CoV2 pandemic
Background: Antibody diagnostics play an important role in disease detection and can potentially aid in monitoring of the immune responses…
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PLOS ONE Computed tomography characterization and outcome evaluation of COVID-19 pneumonia complicated by venous thromboembolism
Background: COVID-19 is frequently complicated by venous thromboembolism (VTE). Computed tomography (CT) of the chest—primarily usually…
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PLOS Neglected Tropical Diseases Spatial analysis of COVID-19 spread in Iran: Insights into geographical and structural transmission determinants at a province level
The Islamic Republic of Iran reported its first COVID-19 cases by 19th February 2020, since then it has become one of the most affected…
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PLOS ONE Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study
The outbreak of SARS-CoV-2 began in December 2019 and rapidly became a pandemic. The present study investigated the significance of…
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PLOS ONE EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2
Due to the challenges for developing vaccines in devastating pandemic situations of severe acute respiratory syndrome coronavirus 2…
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PLOS ONE Early indicators of intensive care unit bed requirement during the COVID-19 epidemic: A retrospective study in Ile-de-France region, France
The aim of our retrospective study was to evaluate the earliest COVID19-related signal to anticipate requirements of intensive care unit…
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PLOS ONE Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis
Background: Understanding the factors associated with disease severity and mortality in Coronavirus disease (COVID-19) is imperative to…
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PLOS ONE Overweight/obesity as the potentially most important lifestyle factor associated with signs of pneumonia in COVID-19
Objective: The occurrence of pneumonia separates severe cases of COVID-19 from the majority of cases with mild disease. However, the…
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PLOS ONE Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review
Background and purpose: The objective of our systematic review is to identify prognostic factors that may be used in decision-making…
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PLOS ONE Clinical, regional, and genetic characteristics of Covid-19 patients from UK Biobank
Background: Coronavirus disease 2019 (Covid-19) has rapidly infected millions of people worldwide. Recent studies suggest that racial…
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PLOS ONE An efficient mixture of deep and machine learning models for COVID-19 diagnosis in chest X-ray images
A newly emerged coronavirus (COVID-19) seriously threatens human life and health worldwide. In coping and fighting against COVID-19, the…
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PLOS ONE Incidence and risk factors of kidney impairment on patients with COVID-19: A meta-analysis of 10180 patients
Background: The novel coronavirus is pandemic around the world. Several researchers have given the evidence of impacts of COVID-19 on the…
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PLOS ONE Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study
Background: This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital. Methods: This retrospective…
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PLOS Biology Superspreading events in the transmission dynamics of SARS-CoV-2: Opportunities for interventions and control
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of the Coronavirus Disease 2019 (COVID-19) disease,…
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PLOS ONE Repurposing therapeutics for COVID-19: Rapid prediction of commercially available drugs through machine learning and docking
Background: The outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus has spread rapidly around the globe…
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PLOS ONE Machine learning in predicting respiratory failure in patients with COVID-19 pneumonia—Challenges, strengths, and opportunities in a global health emergency
Aims: The aim of this study was to estimate a 48 hour prediction of moderate to severe respiratory failure, requiring mechanical…
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PLOS ONE Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020
Background: Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan,…
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PLOS ONE SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study
Serological surveys have been conducted to establish prevalence for COVID-19 antibodies in various cohorts and communities, reporting a…
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PLOS ONE Analyzing inter-reader variability affecting deep ensemble learning for COVID-19 detection in chest radiographs
Data-driven deep learning (DL) methods using convolutional neural networks (CNNs) demonstrate promising performance in natural image…
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PLOS ONE COVID-19 in-hospital mortality and mode of death in a dynamic and non-restricted tertiary care model in Germany
Background: Reported mortality of hospitalised Coronavirus Disease-2019 (COVID-19) patients varies substantially, particularly in…
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PLOS ONE Electronic health record analysis identifies kidney disease as the leading risk factor for hospitalization in confirmed COVID-19 patients
Background: Empirical data on conditions that increase risk of coronavirus disease 2019 (COVID-19) progression are needed to identify high…
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PLOS ONE Unmet clinical needs for COVID-19 tests in UK health and social care settings
There is an urgent requirement to identify which clinical settings are in most need of COVID-19 tests and the priority role(s) for tests…
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PLOS ONE Reproductive number of coronavirus: A systematic review and meta-analysis based on global level evidence
Background: The coronavirus (SARS-COV-2) is now a global concern because of its higher transmission capacity and associated adverse…
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PLOS ONE Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving…
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PLOS ONE Development and validation of a 30-day mortality index based on pre-existing medical administrative data from 13,323 COVID-19 patients: The Veterans Health Administration COVID-19 (VACO) Index
Background: Available COVID-19 mortality indices are limited to acute inpatient data. Using nationwide medical administrative data…
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PLOS Biology Monitor for COVID-19 vaccine resistance evolution during clinical trials
Although less common than the evolution of antimicrobial drug resistance, vaccine resistance can and has evolved. How likely is it that…
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PLOS Neglected Tropical Diseases COVID-19 unfolding filariasis: The first case of SARS-CoV-2 and Wuchereria bancrofti coinfection
With the evolution of the Coronavirus Disease 2019 (COVID-19) pandemic, the number of patients brought to medical attention has increased.…
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PLOS Neglected Tropical Diseases Modeling the stability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on skin, currency, and clothing
A new coronavirus (SARS-CoV-2) emerged in the winter of 2019 in Wuhan, China, and rapidly spread around the world. The extent and…
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PLOS ONE Comparative effectiveness and safety of antiviral agents for patients with COVID-19: Protocol for a systematic review and individual-patient data network meta-analysis
Background: A recent cluster of pneumonia cases in Wuhan, China, has been caused by severe acute respiratory syndrome coronavirus 2…
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PLOS ONE Human mobility trends during the early stage of the COVID-19 pandemic in the United States
In March of this year, COVID-19 was declared a pandemic, and it continues to threaten public health. This global health crisis imposes…
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PLOS ONE Projected impact of COVID-19 mitigation strategies on hospital services in the Mexico City Metropolitan Area
Evidence-based models may assist Mexican government officials and health authorities in determining the safest plans to respond to the…
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PLOS ONE Modelling the initial epidemic trends of COVID-19 in Italy, Spain, Germany, and France
The Coronavirus Disease 2019 (COVID-19) has fast spread to over 200 countries and regions worldwide since its outbreak, while in March,…
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PLOS ONE Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection
Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it is unknown if COVID-19 results in…
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PLOS ONE Prevalence of SARS-CoV-2 among high-risk populations in Lomé (Togo) in 2020
Background: In December 2019, the COVID-19 outbreak began in China and quickly spread throughout the world and was reclassified as a…
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PLOS Biology A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led…
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PLOS ONE Beyond the peak: A deterministic compartment model for exploring the Covid-19 evolution in Italy
Novel Covid-19 has had a huge impact on the world’s population since December 2019. The very rapid spreading of the virus worldwide, with…
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PLOS ONE Pattern of COVID-19 in Sichuan province, China: A descriptive epidemiological analysis
This study described the epidemiology of 487 confirmed coronavirus disease 2019 (COVID-19) cases in Sichuan province of China, and aimed…
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PLOS ONE A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study
The COVID-19 is rapidly scattering worldwide, and the number of cases in the Eastern Mediterranean Region is rising. Thus, there is a need…
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PLOS ONE The impact of individual lifestyle and status on the acquisition of COVID-19: A case—Control study
Background: Coronavirus disease 2019 (COVID-19) has spread to the world. Whether there is an association between lifestyle behaviors and…
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PLOS ONE Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants
Introduction: Older people have been reported to be at higher risk of COVID-19 mortality. This study explored the factors mediating this…
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PLOS ONE Air and surface measurements of SARS-CoV-2 inside a bus during normal operation
Transmission pathways of SARS-CoV-2 are aerosol, droplet and touching infected material. The diffusion of the virus contagion among people…
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PLOS ONE A national study to assess pharmacists’ preparedness against COVID-19 during its rapid rise period in Pakistan
To evaluate the pharmacist’s preparedness against the COVID-19 during its rapid rise period in Pakistan, an online cross-sectional study…
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PLOS ONE Ocular surface manifestations of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis
Purpose: This study was performed to determine the occurrence of ocular surface manifestations in patients diagnosed with coronavirus…
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PLOS ONE Monitoring life expectancy levels during the COVID-19 pandemic: Example of the unequal impact of the first wave on Spanish regions
Background: To provide an interpretable summary of the impact on mortality of the COVID-19 pandemic we estimate weekly and annual life…
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PLOS ONE Boosting test-efficiency by pooled testing for SARS-CoV-2—Formula for optimal pool size
In the current COVID19 crisis many national healthcare systems are confronted with an acute shortage of tests for confirming SARS-CoV-2…
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PLOS ONE Clinical characteristics of re-positive COVID-19 patients in Huangshi, China: A retrospective cohort study
A cluster of patients with coronavirus disease 2019 (COVID-19) underwent repeated positive severe acute respiratory syndrome coronavirus 2…
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PLOS ONE Liver injury with COVID-19 based on gastrointestinal symptoms and pneumonia severity
Background/Aim: The coronavirus disease 2019 (COVID-19) had become a big threat worldwide. Liver injury is not uncommon in patients with…
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PLOS ONE Predictors of in-hospital COVID-19 mortality: A comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions
Objective: Risk factors for in-hospital mortality in confirmed COVID-19 patients have been summarized in numerous meta-analyses, but it is…
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PLOS ONE Low-dose chest CT for diagnosing and assessing the extent of lung involvement of SARS-CoV-2 pneumonia using a semi quantitative score
Objectives: The purpose is to assess the ability of low-dose CT (LDCT) to determine lung involvement in SARS-CoV-2 pneumonia and to…
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PLOS ONE Characteristics and outcomes of hospitalised patients with acute kidney injury and COVID-19
Introduction: COVID-19 has spread globally to now be considered a pandemic by the World Health Organisation. Initially patients appeared to…
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PLOS ONE COVID-19 gender susceptibility and outcomes: A systematic review
Background: Epidemiological differences between men and women have been reported with regards to sepsis, influenza and severe coronavirus…
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PLOS ONE Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: A systematic review and meta-analysis
Background: The study objective was to conduct a systematic review and meta-analysis on the proportion of asymptomatic infection among…
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PLOS ONE Clinical impact of monocyte distribution width and neutrophil-to-lymphocyte ratio for distinguishing COVID-19 and influenza from other upper respiratory tract infections: A pilot study
The coronavirus disease 2019 (COVID-19) has become a pandemic. Rapidly distinguishing COVID-19 from other respiratory infections is a…
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PLOS ONE Performance of nucleocapsid and spike-based SARS-CoV-2 serologic assays
There is an urgent need for an accurate antibody test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We have developed…
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PLOS Medicine Acute kidney injury associated with COVID-19: A retrospective cohort study
Background: Initial reports indicate a high incidence of acute kidney injury (AKI) in Coronavirus Disease 2019 (COVID-19), but more data…
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PLOS ONE Effect of blood analysis and immune function on the prognosis of patients with COVID-19
Introduction: This retrospective study investigated the implications of changes in blood parameters and cellular immune function in…
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PLOS ONE Silent disease and loss of taste and smell are common manifestations of SARS-COV-2 infection in a quarantine facility: Saudi Arabia
Objectives: In this study, we aimed to study the clinical presentations, and viral clearance of SARS-COV-2 positive quarantined…
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PLOS Pathogens On the whereabouts of SARS-CoV-2 in the human body: A systematic review
Since SARS-CoV-2 appeared in the human population, the scientific community has scrambled to gather as much information as possible to…
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PLOS Neglected Tropical Diseases SARS-CoV-2 in the Amazon region: A harbinger of doom for Amerindians
As the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic continues to expand, healthcare resources globally have been…
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PLOS Pathogens “Trained immunity” from Mycobacterium spp. exposure or BCG vaccination and COVID-19 outcomes
Protective variables for Coronavirus Disease 2019 (COVID-19) are unknown. “Trained immunity” of the populace as a result of Bacille…
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PLOS ONE The values of coagulation function in COVID-19 patients
Objective: To investigate the blood coagulation function in COVID-19 patients, and the correlation between coagulopathy and disease…
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PLOS ONE Assessing COVID-19 risk, vulnerability and infection prevalence in communities
Background: The spread of coronavirus in the United States with nearly five and half million confirmed cases and over 170,000 deaths has…
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PLOS ONE The first wave of COVID-19 in Israel—Initial analysis of publicly available data
The first case of COVID-19 was confirmed in Israel on February 21, 2020. Within approximately 30 days, the total number of confirmed cases…
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PLOS ONE SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts, Thailand, April-June 2020
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although Thailand has…
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PLOS ONE On the temporal spreading of the SARS-CoV-2
The behaviour of SARS-CoV-2 virus is certainly one of the most challenging in contemporary world. Although the mathematical modelling of…
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PLOS ONE Facilitators and barriers to engagement with contact tracing during infectious disease outbreaks: A rapid review of the evidence
Background: Until a vaccine is developed, a test, trace and isolate strategy is the most effective method of controlling the COVID-19…
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PLOS ONE Estimation of the percentages of undiagnosed patients of the novel coronavirus (SARS-CoV-2) infection in Hokkaido, Japan by using birth-death process with recursive full tracing
Estimating the percentages of undiagnosed and asymptomatic patients is essential for controlling the outbreak of SARS-CoV-2, and for…
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PLOS ONE Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2
Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of…
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PLOS ONE COVID-19 outbreak in long-term care facilities from Spain. Many lessons to learn
Background/Objectives: To analyze mortality, costs, residents and personnel characteristics, in six long-term care facilities (LTCF) during…
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PLOS ONE Evaluation of SARS-CoV-2 IgG antibody response in PCR positive patients: Comparison of nine tests in relation to clinical data
SARS-CoV-2 antibody tests are available in various formats, detecting different viral target proteins and antibody subclasses. The…
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PLOS ONE Cancer inpatients with COVID-19: A report from the Brazilian National Cancer Institute
Objective: This study aimed to describe the demographic and clinical characteristics of cancer inpatients with COVID-19 exploring clinical…
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PLOS ONE Surgery for non-Covid-19 patients during the pandemic
Background: In the early phase of the Covid-19 pandemic, mainly data related to the burden of care required by infected patients were…
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PLOS ONE Prevalence of underlying diseases in died cases of COVID-19: A systematic review and meta-analysis
Introduction: Underlying disease have a critical role in vulnerability of populations for a greater morbidity and mortality when they…
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PLOS Neglected Tropical Diseases Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study
Modelling, Forecasting, and Surveillance
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PLOS ONE Estimating the impact of interventions against COVID-19: From lockdown to vaccination
Coronavirus disease 2019 (COVID-19) is an infectious disease of humans caused by severe acute respiratory syndrome coronavirus 2…
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Image creditsars cov 2 antibody by creative bio11, CC BY 2.0PLOS ONE Seroprevalence of SARS-CoV-2 antibodies and retrospective mortality in a refugee camp, Dagahaley, Kenya
Background: Camps of forcibly displaced populations are considered to be at risk of large COVID-19 outbreaks. Low screening rates and…
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PLOS ONE A method for campus-wide SARS-CoV-2 surveillance at a large public university
The systematic screening of asymptomatic and pre-symptomatic individuals is a powerful tool for controlling community transmission of…
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PLOS Medicine Access to and safety of COVID-19 convalescent plasma in the United States Expanded Access Program: A national registry study
Background: The United States (US) Expanded Access Program (EAP) to coronavirus disease 2019 (COVID-19) convalescent plasma was initiated…
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Image creditSocial distancing by Olivier, CC BY 2.0PLOS ONE Social distancing practice and associated factors in response to COVID-19 pandemic at West Guji Zone, Southern Ethiopia, 2021: A community based cross-sectional study
Background: Curtailing physical contact between individuals reduces transmission and spread of the disease. Social distancing is an…
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PLOS ONE Maternal mortality associated with COVID-19 in Brazil in 2020 and 2021: Comparison with non-pregnant women and men
Objective: Mortality rates of pregnant and postpartum women grew in the second COVID-19 pandemic year. Our objective is to understand this…
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PLOS ONE Assessing vaccination priorities for different ages and age-specific vaccination strategies of COVID-19 using an SEIR modelling approach
In the past year, the global epidemic situation is still not optimistic, showing a trend of continuous expansion. With the research and…
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PLOS ONE The risks and benefits of providing HIV services during the COVID-19 pandemic
Introduction: The COVID-19 pandemic has caused widespread disruptions including to health services. In the early response to the pandemic…
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PLOS ONE Evaluating the impacts of non-pharmaceutical interventions on the transmission dynamics of COVID-19 in Canada based on mobile network
The COVID-19 outbreak has caused two waves and spread to more than 90% of Canada’s provinces since it was first reported more than a year…
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PLOS ONE Validation and deployment of a direct saliva real-time RT-PCR test on pooled samples for COVID-19 surveillance testing
A direct, real-time reverse transcriptase PCR test on pooled saliva was validated in 2,786 participants against oropharyngeal swabs. Among…
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PLOS ONE Active environmental surveillance of SARS-CoV-2 in Midwestern United States meatpacking plants
This pilot project investigated environmental SARS-CoV-2 presence in seven Midwestern meatpacking plants from May 2020 to January 2021.…
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PLOS ONE How does the community COVID-19 level of risk impact on that of a care home?
Objectives: To model the risk of COVID-19 mortality in British care homes conditional on the community level risk. Methods: A two stage…
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PLOS ONE Super.Complex: A supervised machine learning pipeline for molecular complex detection in protein-interaction networks
Characterization of protein complexes, i.e. sets of proteins assembling into a single larger physical entity, is important, as such…
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PLOS Computational Biology Microsimulation based quantitative analysis of COVID-19 management strategies
Pandemic management requires reliable and efficient dynamical simulation to predict and control disease spreading. The COVID-19…
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PLOS ONE A 12-hospital prospective evaluation of a clinical decision support prognostic algorithm based on logistic regression as a form of machine learning to facilitate decision making for patients with suspected COVID-19
Objective: To prospectively evaluate a logistic regression-based machine learning (ML) prognostic algorithm implemented in real-time as a…
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PLOS Neglected Tropical Diseases Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study
Background: The first community transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant of concern…
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PLOS ONE Pandemic-related declines in hospitalization for non-COVID-19-related illness in the United States from January through July 2020
Background: The COVID-19 pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has substantially…
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PLOS Medicine Factors associated with excess all-cause mortality in the first wave of the COVID-19 pandemic in the UK: A time series analysis using the Clinical Practice Research Datalink
Background: Excess mortality captures the total effect of the Coronavirus Disease 2019 (COVID-19) pandemic on mortality and is not affected…
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PLOS ONE Improved log-Gaussian approximation for over-dispersed Poisson regression: Application to spatial analysis of COVID-19
In the era of open data, Poisson and other count regression models are increasingly important. Still, conventional Poisson regression has…
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PLOS ONE COVID-19 outbreaks in nursing homes: A strong link with the coronavirus spread in the surrounding population, France, March to July 2020
Background: Worldwide, COVID-19 outbreaks in nursing homes have often been sudden and massive. The study investigated the role SARS-CoV-2…
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PLOS ONE The mediation of perceived risk’s impact on destination image and travel intention: An empirical study of Chengdu, China during COVID-19
Perceived risk clearly impacts travel behavior, including destination selection and satisfaction, but it is unclear how or why its effect…
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PLOS ONE A systematic review of methodological approaches for evaluating real-world effectiveness of COVID-19 vaccines: Advising resource-constrained settings
Real-world effectiveness studies are important for monitoring performance of COVID-19 vaccination programmes and informing COVID-19…
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PLOS ONE Prediction of mortality in hospitalized Egyptian patients with Coronavirus disease-2019: A multicenter retrospective study
We aimed to assess the epidemiological, clinical, and laboratory characteristics associated with mortality among hospitalized Egyptian…
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PLOS ONE How social learning shapes the efficacy of preventative health behaviors in an outbreak
The global pandemic of COVID-19 revealed the dynamic heterogeneity in how individuals respond to infection risks, government orders, and…
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PLOS ONE Comparison of longitudinal trends in self-reported symptoms and COVID-19 case activity in Ontario, Canada
Background: Limitations in laboratory diagnostic capacity impact population surveillance of COVID-19. It is currently unknown whether…
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PLOS Computational Biology Optimal vaccine allocation for COVID-19 in the Netherlands: A data-driven prioritization
For the control of COVID-19, vaccination programmes provide a long-term solution. The amount of available vaccines is often limited, and…
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PLOS ONE Contact network analysis of Covid-19 in tourist areas——Based on 333 confirmed cases in China
The spread of infectious diseases is highly related to the structure of human networks. Analyzing the contact network of patients can help…
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PLOS Medicine Introduction and expansion of the SARS-CoV-2 B.1.1.7 variant and reinfections in Qatar: A nationally representative cohort study
Background: The epidemiology of the SARS-CoV-2 B.1.1.7 (or Alpha) variant is insufficiently understood. This study’s objective was to…
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PLOS Computational Biology A proposed workflow for proactive virus surveillance and prediction of variants for vaccine design
…
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PLOS Medicine Changes in the associations of race and rurality with SARS-CoV-2 infection, mortality, and case fatality in the United States from February 2020 to March 2021: A population-based cohort study
Background: We examined whether key sociodemographic and clinical risk factors for Severe Acute Respiratory Syndrome Coronavirus 2…
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PLOS ONE Stratifying the early radiologic trajectory in dyspneic patients with COVID-19 pneumonia
Objective: This study aimed to stratify the early pneumonia trajectory on chest radiographs and compare patient characteristics in dyspneic…
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PLOS Computational Biology OutbreakFlow: Model-based Bayesian inference of disease outbreak dynamics with invertible neural networks and its application to the COVID-19 pandemics in Germany
Mathematical models in epidemiology are an indispensable tool to determine the dynamics and important characteristics of infectious…
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PLOS ONE SARS-CoV-2 infection in central North Carolina: Protocol for a population-based longitudinal cohort study and preliminary participant results
Public health surveillance systems likely underestimate the true prevalence and incidence of SARS-CoV-2 infection due to limited access to…
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PLOS ONE Reopening California: Seeking robust, non-dominated COVID-19 exit strategies
The COVID-19 pandemic required significant public health interventions from local governments. Although nonpharmaceutical interventions…
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PLOS ONE Predicting the effects of COVID-19 related interventions in urban settings by combining activity-based modelling, agent-based simulation, and mobile phone data
Epidemiological simulations as a method are used to better understand and predict the spreading of infectious diseases, for example of…
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Image creditSupermarket by fotografierenderpunk, CC BY 2.0PLOS ONE Extent of compliance with COVID-19 prevention and control guidelines among supermarkets in Kampala Capital City and Mukono Municipality, Uganda
Background: Despite the development and enforcement of preventive guidelines by governments, COVID-19 continues to spread across nations,…
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PLOS Computational Biology Synergistic interventions to control COVID-19: Mass testing and isolation mitigates reliance on distancing
Stay-at-home orders and shutdowns of non-essential businesses are powerful, but socially costly, tools to control the pandemic spread of…
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PLOS ONE Modeling non-pharmaceutical interventions in the COVID-19 pandemic with survey-based simulations
Governments around the globe use non-pharmaceutical interventions (NPIs) to curb the spread of coronavirus disease 2019 (COVID-19) cases.…
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PLOS ONE Does the data tell the true story? A modelling assessment of early COVID-19 pandemic suppression and mitigation strategies in Ghana
This paper uses publicly available data and various statistical models to estimate the basic reproduction number (R0) and other disease…
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PLOS ONE On the effectiveness of communication strategies as non-pharmaceutical interventions to tackle epidemics
When pharmaceutical interventions are unavailable to deal with an epidemic outbreak, adequate management of communication strategies can…
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PLOS ONE Strategies to increase downloads of COVID–19 exposure notification apps: A discrete choice experiment
Exposure notification apps have been developed to assist in notifying individuals of recent exposures to SARS-CoV-2. However, in several…
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PLOS ONE The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review
Background: A year following the onset of the COVID-19 pandemic, new infections and deaths continue to increase in Europe. Serological…
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PLOS ONE Detecting and describing stability and change in COVID-19 vaccine receptibility in the United Kingdom and Ireland
COVID-19 continues to pose a threat to global public health. Multiple safe and effective vaccines against COVID-19 are available with…
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PLOS ONE Predicting increases in COVID-19 incidence to identify locations for targeted testing in West Virginia: A machine learning enhanced approach
During the COVID-19 pandemic, West Virginia developed an aggressive SARS-CoV-2 testing strategy which included utilizing pop-up mobile…
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PLOS ONE Modeling the differences in the time-series profiles of new COVID-19 daily confirmed cases in 3,108 contiguous U.S. counties: A retrospective analysis
Objective: The COVID-19 pandemic in the U.S. has exhibited a distinct multiwave pattern beginning in March 2020. Paradoxically, most…
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PLOS ONE Investigating differential effects of socio-emotional and mindfulness-based online interventions on mental health, resilience and social capacities during the COVID-19 pandemic: The study protocol
Background: The SARS-CoV-2 pandemic has led to a mental health crisis on a global scale. Epidemiological studies have reported a drastic…
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PLOS ONE The Theory of Planned Behavior during the COVID-19 pandemic: A comparison of health behaviors between Belgian and French residents
The COVID-19 pandemic presents a global crisis and authorities have encouraged the population to promote preventive health behaviors to…
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PLOS ONE Accuracy of deep learning-based computed tomography diagnostic system for COVID-19: A consecutive sampling external validation cohort study
Ali-M3, an artificial intelligence program, analyzes chest computed tomography (CT) and detects the likelihood of coronavirus disease…
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Image creditCOVID Testing by City of Greenville, North Carolina, CC BY 2.0PLOS ONE The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up
The first case of COVID-19 in Nigeria was recorded on February 27, 2020, being an imported case by an Italian expatriate, to the country.…
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Image creditCOVID-19 - HealthCare by Total Shape, CC BY 2.0PLOS Medicine SARS-CoV-2 vaccine uptake in a multi-ethnic UK healthcare workforce: A cross-sectional study
Background: Healthcare workers (HCWs) and ethnic minority groups are at increased risk of COVID-19 infection and adverse outcomes. Severe…
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CC 0 ">Image creditCOVID-19 - The year of the virus by joncutrer, CC 0 blic-domain/cc0/">CC 0PLOS ONE The impact of government responses to the COVID-19 pandemic on GDP growth: Does strategy matter?
We analyze whether and to what extent strategies employed by governments to fight the COVID-19 pandemic made a difference for GDP growth…
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Image creditGerman flag by fdecomite, CC BY 2.0PLOS ONE Attitudes towards the economic costs associated with measures against the spread of COVID-19: Population perceptions from repeated cross-sectional data of the nationally representative COVID-19 Snapshot Monitoring in Germany (COSMO)
Introduction: Our aim was to examine attitudes of the general population towards reasonableness of these costs, as well as the degree to…
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CC 0 ">Image creditChildrens holding hands by Wallboat, CC 0 blic-domain/cc0/">CC 0PLOS ONE A cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United States
Background: Pediatric SARS-CoV-2 data remain limited and seropositivity rates in children were reported as <1% early in the pandemic.…
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PLOS ONE Network percolation reveals adaptive bridges of the mobility network response to COVID-19
Human mobility is crucial to understand the transmission pattern of COVID-19 on spatially embedded geographic networks. This pattern seems…
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CC 0 ">Image creditThe R Family - 2 by RebeccaVC1, CC 0 blic-domain/cc0/">CC 0PLOS ONE High variability in transmission of SARS-CoV-2 within households and implications for control
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a high risk of transmission in close-contact indoor…
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PLOS ONE COVID-19 vaccine hesitancy and refusal and associated factors in an adult population in Saskatchewan, Canada: Evidence from predictive modelling
Background: A high population level of vaccination is required to control the COVID-19 pandemic, but not all Canadians are convinced of the…
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PLOS ONE Can vaccination roll-out be more equitable if population risk is taken into account?
Background: COVID-19 vaccination in many countries, including England, has been prioritised primarily by age. However, people of the same…
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PLOS ONE Assessing the impact of non-pharmaceutical interventions (NPI) on the dynamics of COVID-19: A mathematical modelling study of the case of Ethiopia
The World Health Organization (WHO) declared COVID-19 a pandemic on March 11, 2020 and by November 14, 2020 there were 53.3M confirmed…
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PLOS ONE Evaluation of the United States COVID-19 vaccine allocation strategy
Background: Anticipating an initial shortage of vaccines for COVID-19, the Centers for Disease Control (CDC) in the United States developed…
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PLOS ONE The Impact of Disease Control Measures on the Spread of COVID-19 in the Province of Sindh, Pakistan
The province of Sindh reported the first COVID-19 case in Pakistan on 26th February 2020. The Government of Sindh has employed numerous…
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PLOS ONE Lessons learned from the rapid development of a statewide simulation model for predicting COVID-19’s impact on healthcare resources and capacity
The first case of COVID-19 was detected in North Carolina (NC) on March 3, 2020. By the end of April, the number of confirmed cases had…
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PLOS ONE Modelling digital and manual contact tracing for COVID-19. Are low uptakes and missed contacts deal-breakers?
Comprehensive testing schemes, followed by adequate contact tracing and isolation, represent the best public health interventions we can…
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CC 0 ">Image creditMinister Fikile Mbalula inspects Rea-Vaya buses and stations as part of Coronavirus Covid-19 safety measures by GovernmentZA, CC 0 blic-domain/cc0/">CC 0PLOS ONE Effectiveness of vaccination against SARS-CoV-2 infection and Covid-19 hospitalisation among Finnish elderly and chronically ill—An interim analysis of a nationwide cohort study
Background: In Finland, both mRNA and adenovirus vector (AdV) Covid-19 vaccines have been used after the vaccination campaign started on…
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PLOS ONE Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal
COVID-19 mainly presents as a respiratory disease with flu‐like symptoms, however, recent findings suggest that non-respiratory symptoms…
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PLOS ONE Relationship between out-of-hospital cardiac arrests and COVID-19 during the first and second pandemic wave. The importance of monitoring COVID-19 incidence
Background: The relationship between COVID-19 and out-of-hospital cardiac arrests (OHCAs) has been shown during different phases of the…
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10.1371/journal.pone.0257979 CC BY 4.0" title="10.1371/journal.pone.0257979 CC BY 4.0">Image creditPLOS ONE Changes in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City
Public health interventions such as social distancing and mask wearing decrease the incidence of severe acute respiratory syndrome…
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PLOS ONE Modelling COVID-19 transmission in a hemodialysis centre using simulation generated contacts matrices
The COVID-19 pandemic has been particularly threatening to patients with end-stage kidney disease (ESKD) on intermittent hemodialysis and…
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Image creditModel of coronavirus or other virus made from plasticine and pins in hand with glove by Marco Verch Professional Photographer, CC BY 2.0PLOS ONE Prevalence and correlates of forgone care among adult Israeli Jews: A survey conducted during the COVID-19 outbreak
Efforts to control the spread of the novel Coronavirus (COVID-19) pandemic include drastic measures such as isolation, social distancing,…
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PLOS ONE Towards a COVID-19 symptom triad: The importance of symptom constellations in the SARS-CoV-2 pandemic
Pandemic scenarios like SARS-Cov-2 require rapid information aggregation. In the age of eHealth and data-driven medicine, publicly…
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PLOS ONE Modelling aerosol-based exposure to SARS-CoV-2 by an agent based Monte Carlo method: Risk estimates in a shop and bar
Present day risk assessment on the spreading of airborne viruses is often based on the classical Wells-Riley model assuming immediate…
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PLOS ONE Protective measures are associated with the reduction of transmission of COVID-19 in Bangladesh: A nationwide cross-sectional study
Coronavirus disease 2019 (COVID-19) pandemic has become a major public health issue globally. Preventive health measures against COVID-19…
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PLOS ONE Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission
At present, global immunity to SARS-CoV-2 resides within a heterogeneous combination of susceptible, naturally infected and vaccinated…
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PLOS ONE Comprehensive occupational health services for healthcare workers in Zimbabwe during the SARS-CoV-2 pandemic
Background: Healthcare workers are disproportionately affected by COVID-19. In low- and middle- income countries, they may be particularly…
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Image creditA word cloud featuring "Covid-19" by EpicTop10.com, CC BY 2.0PLOS ONE Effectiveness of non-pharmaceutical public health interventions against COVID-19: A systematic review and meta-analysis
Non-Pharmaceutical Public Health Interventions (NPHIs) have been used by different countries to control the spread of the COVID-19.…
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PLOS ONE Bayesian inference across multiple models suggests a strong increase in lethality of COVID-19 in late 2020 in the UK
We apply Bayesian inference methods to a suite of distinct compartmental models of generalised SEIR type, in which diagnosis and…
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PLOS Computational Biology Data-driven multi-scale mathematical modeling of SARS-CoV-2 infection reveals heterogeneity among COVID-19 patients
Patients with coronavirus disease 2019 (COVID-19) often exhibit diverse disease progressions associated with various infectious ability,…
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PLOS ONE Rapid relaxation of pandemic restrictions after vaccine rollout favors growth of SARS-CoV-2 variants: A model-based analysis
The development and deployment of several SARS-CoV-2 vaccines in a little over a year is an unprecedented achievement of modern medicine.…
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PLOS ONE Surveillance for face mask compliance, Chennai, Tamil Nadu, India, October-December, 2020
Purpose: Government of Tamil Nadu, India, mandated the face mask wearing in public places as one of the mitigation measures of COVID-19. We…
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Image creditFig 1. Characteristic analysis of the data by Singhal et al., CC BY 4.0PLOS ONE eARDS: A multi-center validation of an interpretable machine learning algorithm of early onset Acute Respiratory Distress Syndrome (ARDS) among critically ill adults with COVID-19
We present an interpretable machine learning algorithm called ‘eARDS’ for predicting ARDS in an ICU population comprising COVID-19…
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PLOS ONE Repurposing FIB-4 index as a predictor of mortality in patients with hematological malignancies and COVID-19
Background: In this study, we aimed to investigate whether FIB-4 index is useful in predicting mortality in patients with concurrent…
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PLOS ONE An optimized stepwise algorithm combining rapid antigen and RT-qPCR for screening of COVID-19 patients
Background & aim: We investigated the combination of rapid antigen detection (RAD) and RT-qPCR assays in a stepwise procedure to optimize…
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PLOS ONE Was R < 1 before the English lockdowns? On modelling mechanistic detail, causality and inference about Covid-19
Detail is a double edged sword in epidemiological modelling. The inclusion of mechanistic detail in models of highly complex systems has…
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Image creditFig 3. The social distancing effect on mobility by Glogowsky et al., CC BY 2.0PLOS ONE How effective are social distancing policies? Evidence on the fight against COVID-19
To fight the spread of COVID-19, many countries implemented social distancing policies. This is the first paper that examines the effects…
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PLOS Computational Biology Levels of SARS-CoV-2 population exposure are considerably higher than suggested by seroprevalence surveys
Accurate knowledge of prior population exposure has critical ramifications for preparedness plans for future SARS-CoV-2 epidemic waves and…
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PLOS ONE Identification of high-risk COVID-19 patients using machine learning
The current COVID-19 public health crisis, caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has produced a…
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Image creditFig 3. Transition probabilities for two typical patients of ages 40 and 75 by Álvarez-Esteban et al., CC BY 4.0PLOS ONE Predicting COVID-19 progression from diagnosis to recovery or death linking primary care and hospital records in Castilla y León (Spain)
This paper analyses COVID-19 patients’ dynamics during the first wave in the region of Castilla y León (Spain) with around 2.4 million…
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PLOS Computational Biology Uncertainty quantification and sensitivity analysis of COVID-19 exit strategies in an individual-based transmission model
Many countries are currently dealing with the COVID-19 epidemic and are searching for an exit strategy such that life in society can…
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PLOS ONE COVID-19 mortality with regard to healthcare services availability, health risks, and socio-spatial factors at department level in France: A spatial cross-sectional analysis
Background: The 2019 coronavirus (COVID-19) epidemic began in Wuhan, China in December 2019 and quickly spread to the rest of the world.…
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PLOS ONE Spatiotemporal analysis and the characteristics of the case transmission network of 2019 novel coronavirus disease (COVID-19) in Zhejiang Province, China
Background: Zhejiang Province is one of the five provinces in China that had the highest incidence of novel coronavirus disease (COVID-19).…
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PLOS ONE Network assessment and modeling the management of an epidemic on a college campus with testing, contact tracing, and masking
There remains a great challenge to minimize the spread of epidemics, especially in high-density communities such as colleges and…
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PLOS ONE Modelling and optimal control of multi strain epidemics, with application to COVID-19
Reinfection and multiple viral strains are among the latest challenges in the current COVID-19 pandemic. In contrast, epidemic models…
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Image creditFig 2. Time series simulations by Khan et al., CC BY 4.0PLOS ONE Effect of high and low risk susceptibles in the transmission dynamics of COVID-19 and control strategies
In this study, we formulate and analyze a deterministic model for the transmission of COVID-19 and evaluate control strategies for the…
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Image creditFig 2. Interplay between vaccine efficacy and rollout speed by Gozzi et al., CC BY 4.0PLOS Computational Biology The importance of non-pharmaceutical interventions during the COVID-19 vaccine rollout
The promise of efficacious vaccines against SARS-CoV-2 is fulfilled and vaccination campaigns have started worldwide. However, the fight…
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PLOS ONE Screening plans for SARS-CoV-2 based on sampling and rotation: An example in a European school setting
Screening plans for prevention and containment of SARS-CoV-2 infection should take into account the epidemic context, the fact that…
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Image creditFig 1. SIR model during lockdown period (until May 30, 2020) by Shimul et al., CC BY 4.0PLOS ONE Effect of easing lockdown and restriction measures on COVID-19 epidemic projection: A case study of Saudi Arabia
Objectives: In this study we compared two predictions of COVID-19 cases in the Kingdom Saudi Arabia (KSA) using pre–and post–relaxation of…
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PLOS Computational Biology An integrated framework for building trustworthy data-driven epidemiological models: Application to the COVID-19 outbreak in New York City
Epidemiological models can provide the dynamic evolution of a pandemic but they are based on many assumptions and parameters that have to…
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PLOS Computational Biology MicrobeTrace: Retooling molecular epidemiology for rapid public health response
Outbreak investigations use data from interviews, healthcare providers, laboratories and surveillance systems. However, integrated use of…
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PLOS Computational Biology Using test positivity and reported case rates to estimate state-level COVID-19 prevalence and seroprevalence in the United States
Accurate estimates of infection prevalence and seroprevalence are essential for evaluating and informing public health responses and…
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PLOS ONE SARS-CoV-2 infections among Australian passengers on the Diamond Princess cruise ship: A retrospective cohort study
Background: Prolonged periods of confined living on a cruise ship increase the risk for respiratory disease transmission. We describe the…
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Image creditFig 1. Schematic of the COVID-19 epidemiologic model by Love et al., CC BY 4.0PLOS ONE Comparison of antigen- and RT-PCR-based testing strategies for detection of SARS-CoV-2 in two high-exposure settings
Surveillance testing for infectious disease is an important tool to combat disease transmission at the population level. During the…
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PLOS Computational Biology Relaxing restrictions at the pace of vaccination increases freedom and guards against further COVID-19 waves
Mass vaccination offers a promising exit strategy for the COVID-19 pandemic. However, as vaccination progresses, demands to lift…
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PLOS ONE Modeling transmission dynamics and effectiveness of worker screening programs for SARS-CoV-2 in pork processing plants
Pork processing plants were apparent hotspots for SARS-CoV2 in the spring of 2020. As a result, the swine industry was confronted with a…
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Image creditFig 2. Accuracy measures from cross–validation by Borrego–Morell et al., CC BY 4.0PLOS ONE On the effect of COVID-19 pandemic in the excess of human mortality. The case of Brazil and Spain
Excess of deaths is a technique used in epidemiology to assess the deaths caused by an unexpected event. For the present COVID–19…
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Image creditFig 1. Air and maritime connections for the shipment of travelers’ self-collected samples from the islands with health care centers participating in the COV-CHECK PORINETIA surveillance strategy, to Tahiti where the Institut Louis Malardé is located; a surface area as wide as Europe. by Aubry et al., CC BY 4.0PLOS ONE Self-collection and pooling of samples as resources-saving strategies for RT-PCR-based SARS-CoV-2 surveillance, the example of travelers in French Polynesia
In French Polynesia, the first case of SARS-CoV-2 infection was detected on March 10th, 2020, in a resident returning from France. Between…
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PLOS ONE Modeling the effects of contact-tracing apps on the spread of the coronavirus disease: Mechanisms, conditions, and efficiency
This study simulates the spread of the coronavirus disease (COVID-19) using a detailed agent-based model and the census data of Japan to…
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PLOS ONE Interpreting COVID-19 deaths among nursing home residents in the US: The changing role of facility quality over time
A report published last year by the Centers for Medicare & Medicaid Services (CMS) highlighted that COVID-19 case counts are more likely…
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PLOS ONE Impact of COVID-19 on excess mortality, life expectancy, and years of life lost in the United States
This paper quantifies the net impact (direct and indirect effects) of the pandemic on the United States population in 2020 using three…
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PLOS ONE Early days of the pandemic—The association of economic and socio-political country characteristics with the development of the COVID-19 death toll
This article examines cross-national differences in growth of deaths by COVID-19 over time in the first phase of the pandemic, during the…
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PLOS ONE Diagnostic performance and clinical implications of rapid SARS-CoV-2 antigen testing in Mexico using real-world nationwide COVID-19 registry data
Background: SARS-CoV-2 testing capacity is important to monitor epidemic dynamics and as a mitigation strategy. Given difficulties of…
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PLOS ONE Feasibility and acceptability of SARS-CoV-2 testing and surveillance in primary school children in England: Prospective, cross-sectional study
Background: The reopening of schools during the COVID-19 pandemic has raised concerns about widespread infection and transmission of…
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Image creditFig 3. Survey region of Xixi National Wetland Park by Qiu et al., CC BY 4.0PLOS ONE Exploring the perceived restorativeness of natural soundscapes under the global pandemic of COVID-19: A moderated mediation model
Although emerging studies have discussed the potential benefits of soundscape in mental restoration, few have investigated how soundscape…
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Image creditFig 1. Contact graphs by Mauras et al., CC BY 4.0PLOS Computational Biology Mitigating COVID-19 outbreaks in workplaces and schools by hybrid telecommuting
The COVID-19 epidemic has forced most countries to impose contact-limiting restrictions at workplaces, universities, schools, and more…
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Image creditFig 2. Temporal distribution of COVID-19 cases by onset of symptoms by Domènech-Montoliu et al., CC BY 4.0PLOS ONE “Mass gathering events and COVID-19 transmission in Borriana (Spain): A retrospective cohort study”
Objective: Mass gathering events (MGEs) are associated with the transmission of COVID-19. Between 6 and 10 March 2020, several MGEs related…
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Image creditElectric tram. by MIKI Yoshihito, CC BY 2.0PLOS ONE The background occurrence of selected clinical conditions prior to the start of an extensive national vaccination program in Japan
Introduction: The COVID-19 pandemic caused by SARS-CoV-2 has now affected tens of millions of people globally. It is the hope that vaccines…
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Image creditYoung woman putting medical protective mask on her face by Nenad Stojkovic, CC BY 2.0PLOS ONE The applicability of basic preventive measures of the pandemic COVID-19 and associated factors among residents in Guraghe Zone
Introduction: Internationally, countries have reacted to the COVID-19 outbreak by introducing key public health non-pharmaceutical…
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Image creditFig 2. Discrimination of the models at the different sites by Wickstrøm et al., CC BY 4.0PLOS ONE Regional performance variation in external validation of four prediction models for severity of COVID-19 at hospital admission: An observational multi-centre cohort study
Background: Prediction models should be externally validated to assess their performance before implementation. Several prediction models…
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Image creditFig 3. Geographical distribution of positivity by Boďová et al., CC BY 4.0PLOS ONE Spatial scales, patterns, and positivity trends of SARS-CoV-2 pandemics in mass rapid antigen testing in Slovakia
We study geographical epidemic scales and patterns and positivity trends of SARS-CoV-2 pandemics in mass antigen testing in Slovakia in…
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Image creditDental tools and protective mask by www.authoritydental.org , CC BY 2.0PLOS ONE Work-life balance amongst dental professionals during the COVID-19 pandemic—A structural equation modelling approach
Background: The Coronavirus disease (COVID-19) outbreak in 2019, has shocked the entire world. As an effort to control the disease spread,…
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Image creditFig 2. Representative temperature profiles by Dabisch et al., CC BY 4.0PLOS Pathogens Seroconversion and fever are dose-pependent in a nonhuman primate model of inhalational COVID-19
While evidence exists supporting the potential for aerosol transmission of SARS-CoV-2, the infectious dose by inhalation remains unknown.…
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PLOS Computational Biology The interplay between vaccination and social distancing strategies affects COVID19 population-level outcomes
Social distancing is an effective population-level mitigation strategy to prevent COVID19 propagation but it does not reduce the number of…
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PLOS ONE Effects of government policies and the Nowruz holidays on confirmed COVID-19 cases in Iran: An intervention time series analysis
Background: Public health policies with varying degrees of restriction have been imposed around the world to prevent the spread of…
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PLOS ONE Sociodemographic, laboratory, image data and predictors of gravity risk in patients with COVID-19
Introduction: The effects, severity, and prognosis of COVID-19 infections do not follow a linear pattern in different locations, but change…
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Image creditFig 1. Log-liner plot of new cases by Tichopád et al., CC BY 4.0PLOS ONE Could the new coronavirus have infected humans prior November 2019?
The pandemic caused by the SARS-CoV-2 virus is believed to originate in China from where it spread to other parts of the world. The first…
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Image creditFig 8. The map of maximum risk by Kuo et al., CC BY 4.0PLOS ONE Airline transportation and arrival time of international disease spread: A case study of Covid-19
In this era of globalization, airline transportation has greatly increased international trade and travel within the World Airport Network…
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Image creditFig 3. Bi-grams and tri-grams for case of India by Chandra et al., CC BY 4.0PLOS ONE COVID-19 sentiment analysis via deep learning during the rise of novel cases
Social scientists and psychologists take interest in understanding how people express emotions and sentiments when dealing with…
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PLOS ONE Analysis of the time course of COVID-19 cases and deaths from countries with extensive testing allows accurate early estimates of the age specific symptomatic CFR values
Background: Knowing the true infected and symptomatic case fatality ratios (IFR and CFR) for COVID-19 is of high importance for…
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Image creditFig 4. Schematic of the network by Bahl et al., CC BY 4.0PLOS ONE Modeling COVID-19 spread in small colleges
We develop an agent-based model on a network meant to capture features unique to COVID-19 spread through a small residential college. We…
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PLOS ONE Data driven high resolution modeling and spatial analyses of the COVID-19 pandemic in Germany
The SARS-CoV-2 virus has spread around the world with over 100 million infections to date, and currently many countries are fighting the…
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PLOS ONE Managing school interaction networks during the COVID-19 pandemic: Agent-based modeling for evaluating possible scenarios when students go back to classrooms
The most unexpected and toughest phenomenon that has occurred in recent times is the global COVID-19 pandemic. One of the first measures…
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PLOS ONE On limits of contact tracing in epidemic control
Contact tracing and quarantine are well established non-pharmaceutical epidemic control tools. The paper aims to clarify the impact of…
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PLOS ONE Validation of a direct-to-PCR COVID-19 detection protocol utilizing mechanical homogenization: A model for reducing resources needed for accurate testing
Efficient and effective viral detection methodologies are a critical piece in the global response to COVID-19, with PCR-based…
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Image creditFig 3. Examples of images obtained from LUS videos after pre-processing by Diaz-Escobar et al., CC BY 4.0PLOS ONE Deep-learning based detection of COVID-19 using lung ultrasound imagery
Background: The COVID-19 pandemic has exposed the vulnerability of healthcare services worldwide, especially in underdeveloped countries.…
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PLOS Computational Biology Using mobility data in the design of optimal lockdown strategies for the COVID-19 pandemic
A mathematical model for the COVID-19 pandemic spread, which integrates age-structured Susceptible-Exposed-Infected-Recovered-Deceased…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS Medicine Accuracy of novel antigen rapid diagnostics for SARS-CoV-2: A living systematic review and meta-analysis
Background: SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs) are increasingly being integrated in testing strategies around the world.…
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PLOS ONE Impact of university re-opening on total community COVID-19 burden
Background: University students have higher average number of contacts than the general population. Students returning to university…
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PLOS ONE The impact of tocilizumab on respiratory support states transition and clinical outcomes in COVID-19 patients. A Markov model multi-state study
Background: The benefit of tocilizumab on mortality and time to recovery in people with severe COVID pneumonia may depend on appropriate…
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PLOS ONE A holistic approach for suppression of COVID-19 spread in workplaces and universities
As society has moved past the initial phase of the COVID-19 crisis that relied on broad-spectrum shutdowns as a stopgap method, industries…
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PLOS ONE The association between intersystem prison transfers and COVID-19 incidence in a state prison system
Prisons are the epicenter of the COVID-19 pandemic. Media reports have focused on whether transfers of incarcerated people between prisons…
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Image creditImage title by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0PLOS ONE Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility
Epidemiological and genetic studies on COVID-19 are currently hindered by inconsistent and limited testing policies to confirm SARS-CoV-2…
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PLOS Pathogens Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19
Since the pandemic of COVID-19 has intensely struck human society, small animal model for this infectious disease is in urgent need for…
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PLOS ONE Impact of physical distancing policy on reducing transmission of SARS-CoV-2 globally: Perspective from government’s response and residents’ compliance
Background: COVID-19 was declared a public health emergency by the World Health Organization (WHO) in January 2020. Various physical…
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PLOS ONE A Bayesian approach to reveal the key role of mask wearing in modulating projected interpersonal distance during the first COVID-19 outbreak
Humans typically create and maintain social bonds through interactions that occur at close social distances. The interpersonal distance of…
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PLOS Neglected Tropical Diseases Pandemic-associated mobility restrictions could cause increases in dengue virus transmission
Background: The COVID-19 pandemic has induced unprecedented reductions in human mobility and social contacts throughout the world. Because…
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Image creditFig 1. Overview of the extended SEIR compartmental model by Zhao et al., CC BY 4.0PLOS ONE Threshold analyses on combinations of testing, population size, and vaccine coverage for COVID-19 control in a university setting
We simulated epidemic projections of a potential COVID-19 outbreak in a residential university population in the United States under…
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PLOS ONE Mechanisms of socioeconomic differences in COVID-19 screening and hospitalizations
Background: Social and ecological differences in early SARS-CoV-2 pandemic screening and outcomes have been documented, but the means by…
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PLOS ONE ODT FLOW: Extracting, analyzing, and sharing multi-source multi-scale human mobility
In response to the soaring needs of human mobility data, especially during disaster events such as the COVID-19 pandemic, and the…
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PLOS ONE Excess mortality due to Covid-19? A comparison of total mortality in 2020 with total mortality in 2016 to 2019 in Germany, Sweden and Spain
Introduction: Excess mortality is a suitable indicator of health consequences of COVID-19 because death from any cause is clearly defined…
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Image creditFig 2. 40-day mortality based on risk score by Berry et al., CC BY 4.0PLOS ONE Development and validation of a prognostic 40-day mortality risk model among hospitalized patients with COVID-19
Objectives: The development of a prognostic mortality risk model for hospitalized COVID-19 patients may facilitate patient treatment…
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PLOS ONE Deep learning with robustness to missing data: A novel approach to the detection of COVID-19
In the context of the current global pandemic and the limitations of the RT-PCR test, we propose a novel deep learning architecture, DFCN…
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Image creditFig 2. Severity and age distribution by Herrmann et al., CC BY 4.0PLOS ONE Description and analysis of representative COVID-19 cases–A retrospective cohort study
Background: Most data on COVID-19 was collected in hospitalized cases. Much less is known about the spectrum of disease in entire…
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PLOS ONE Understanding the psychological impact of the COVID-19 pandemic and containment measures: An empirical model of stress
Epidemics such as COVID-19 and corresponding containment measures are assumed to cause psychological stress. In a survey during the…
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Image creditFig 1. Average testing rates in Colombia, March through early May by Raines et al., CC BY 4.0PLOS ONE The transmission of SARS-CoV-2 is likely comodulated by temperature and by relative humidity
Inferring the impact of climate upon the transmission of SARS-CoV-2 has been confounded by variability in testing, unknown disease…
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PLOS ONE Can we predict the severe course of COVID-19 – a systematic review and meta-analysis of indicators of clinical outcome?
Background: COVID-19 has been reported in over 40million people globally with variable clinical outcomes. In this systematic review and…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain 1.0PLOS ONE Health worries, life satisfaction, and social well-being concerns during the COVID-19 pandemic: Insights from Lebanon
The COVID-19 outbreak has struck Lebanon in its worst period of instability, not only impacting physical health, but also increasing…
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PLOS ONE A seroprevalence survey of anti-SARS-CoV-2 antibodies among individuals 18 years of age or older living in a vulnerable region of the city of São Paulo, Brazil
A second wave of COVID-19 has demonstrated how challenging it will be to achieve sustained control of the disease, even with vaccination…
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PLOS ONE Breakpoint modelling of temporal associations between non-pharmaceutical interventions and symptomatic COVID-19 incidence in the Republic of Ireland
Background: To constrain propagation and mitigate the burden of COVID-19, most countries initiated and continue to implement several…
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Image creditbacteria/viruses by John Voo, CC BY 2.0PLOS ONE Analysis of the specificity of a COVID-19 antigen test in the Slovak mass testing program
Aims: Mass antigen testing programs have been challenged because of an alleged insufficient specificity, leading to a large number of false…
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Image creditFig 1. Model dynamics by Marquioni et al., CC BY 4.0PLOS ONE Modeling neutral viral mutations in the spread of SARS-CoV-2 epidemics
Although traditional models of epidemic spreading focus on the number of infected, susceptible and recovered individuals, a lot of…
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Image creditFig 3. Laboratory process steps by Hage et al., CC BY 4.0PLOS ONE Supporting scale-up of COVID-19 RT-PCR testing processes with discrete event simulation
Testing is critical to mitigating the COVID-19 pandemic, but testing capacity has fallen short of the need in the United States and…
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PLOS ONE The suppression effect of emotional contagion in the COVID-19 pandemic: A multi-layer hybrid modelling and simulation approach
The entire world has suffered a lot since the outbreak of the novel coronavirus (COVID-19) in 2019, so simulation models of COVID-19…
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PLOS ONE The Mean Unfulfilled Lifespan (MUL): A new indicator of the impact of mortality shocks on the individual lifespan, with application to mortality reversals induced by COVID-19
Declines in period life expectancy at birth (PLEB) provide seemingly intuitive indicators of the impact of a cause of death on the…
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PLOS Computational Biology Projecting contact matrices in 177 geographical regions: An update and comparison with empirical data for the COVID-19 era
Mathematical models have played a key role in understanding the spread of directly-transmissible infectious diseases such as Coronavirus…
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Image creditFig 4. Time varying Reff (t) in five regions of France and in Ireland by Cazelles et al, CC BY 4.0PLOS Computational Biology A mechanistic and data-driven reconstruction of the time-varying reproduction number: Application to the COVID-19 epidemic
The effective reproduction number Reff is a critical epidemiological parameter that characterizes the transmissibility of a pathogen.…
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PLOS Computational Biology Covasim: An agent-based model of COVID-19 dynamics and interventions
The COVID-19 pandemic has created an urgent need for models that can project epidemic trends, explore intervention scenarios, and estimate…
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PLOS ONE Modeling the survival times of the COVID-19 patients with a new statistical model: A case study from China
Over the past few months, the spread of the current COVID-19 epidemic has caused tremendous damage worldwide, and unstable many countries…
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Image creditFig 2. Schematic of the network by Cherian et al., CC BY 4.0PLOS Computational Biology Optimizing testing for COVID-19 in India
COVID-19 testing across India uses a mix of two types of tests. Rapid Antigen Tests (RATs) are relatively inexpensive point-of-care…
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PLOS ONE Retrospective analysis of demographic factors in COVID-19 patients entering the Mount Sinai Health System
With the continued rise of the global incidence of COVID-19 infection and emergent second wave, the need to understand characteristics…
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Image creditImage title by Stoddard et al., CC BY 4.0PLOS ONE Beyond the new normal: Assessing the feasibility of vaccine-based suppression of SARS-CoV-2
As the COVID-19 pandemic drags into its second year, there is hope on the horizon, in the form of SARS-CoV-2 vaccines which promise…
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Image creditFig 1. ROC curves in the derivation and validation cohorts by Jiwa et al., CC BY 4.0PLOS ONE Development of a brief scoring system to predict any-cause mortality in patients hospitalized with COVID-19 infection
Patients hospitalized with COVID-19 infection are at a high general risk for in-hospital mortality. A simple and easy-to-use model for…
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PLOS ONE Trends in COVID-19 case-fatality rates in Brazilian public hospitals: A longitudinal cohort of 398,063 hospital admissions from 1st March to 3rd October 2020
Background: Almost 200,000 deaths from COVID-19 were reported in Brazil in 2020. The case fatality rate of a new infectious disease can…
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PLOS ONE Infection control, occupational and public health measures including mRNA-based vaccination against SARS-CoV-2 infections to protect healthcare workers from variants of concern: A 14-month observational study using surveillance data
Background: We evaluated measures to protect healthcare workers (HCWs) in Vancouver, Canada, where variants of concern (VOC) went from <1%…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain Mark 1.0
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PLOS ONE Early centralized isolation strategy for all confirmed cases of COVID-19 remains a core intervention to disrupt the pandemic spreading significantly
Background: In response to the spread of the coronavirus disease 2019 (COVID-19), plenty of control measures were proposed. To assess the…
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PLOS ONE Cure and death play a role in understanding dynamics for COVID-19: Data-driven competing risk compartmental models, with and without vaccination
Several factors have played a strong role in influencing the dynamics of COVID-19 in the U.S. One being the economy, where a tug of war…
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Image creditFig 1. Interplay between θ and τ by Shanmugam et al., CC BY 4.0PLOS ONE Predicting COVID-19 cases with unknown homogeneous or heterogeneous resistance to infectivity
We present a restricted infection rate inverse binomial-based approach to better predict COVID-19 cases after a family gathering. The…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain 1.0PLOS ONE SARS-CoV-2 PCR positivity rate and seroprevalence of related antibodies among a sample of patients in Cairo: Pre-wave 2 results of a screening program in a university hospital
Background: Research has revealed that asymptomatic and pre-symptomatic infections are important contributors to the transmission of…
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Image creditFig 1. Overview of the COVIDomic platform by Naumov et al., CC BY 4.0PLOS Computational Biology COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity
Coronavirus disease 2019 (COVID-19) is an acute infection of the respiratory tract that emerged in December 2019 in Wuhan, China. It was…
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PLOS ONE Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020
The world is currently in a pandemic of COVID-19 (Coronavirus disease-2019) caused by a novel positive-sense, single-stranded RNA…
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PLOS ONE The impact of vaccination to control COVID-19 burden in the United States: A simulation modeling approach
Introduction: Vaccination programs aim to control the COVID-19 pandemic. However, the relative impacts of vaccine coverage, effectiveness,…
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PLOS ONE Sero-surveillance for SARS-CoV-2 infection among healthcare providers in four hospitals in Thailand one year after the first community outbreak
Background: Thailand was the first country outside China to report SARS-CoV-2 infected cases. Since the detection of the first imported…
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PLOS Medicine Investigating associations between COVID-19 mortality and population-level health and socioeconomic indicators in the United States: A modeling study
Background: With the availability of multiple Coronavirus Disease 2019 (COVID-19) vaccines and the predicted shortages in supply for the…
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PLOS ONE A comprehensive estimation of country-level basic reproduction numbers R0 for COVID-19: Regime regression can automatically estimate the end of the exponential phase in epidemic data
In a compartmental epidemic model, the initial exponential phase reflects a fixed interaction between an infectious agent and a…
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PLOS ONE Prediction of 28-day mortality in critically ill patients with COVID-19: Development and internal validation of a clinical prediction model
Background: COVID-19 pandemic has rapidly required a high demand of hospitalization and an increased number of intensive care units (ICUs)…
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PLOS Computational Biology Bayesian back-calculation and nowcasting for line list data during the COVID-19 pandemic
Surveillance is critical to mounting an appropriate and effective response to pandemics. However, aggregated case report data suffers from…
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PLOS Computational Biology OpenABM-Covid19—An agent-based model for non-pharmaceutical interventions against COVID-19 including contact tracing
SARS-CoV-2 has spread across the world, causing high mortality and unprecedented restrictions on social and economic activity.…
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Image creditFig 4. Community detection using the InfoMap algorithm by Gibbs et al., CC BY 4.0PLOS Computational Biology Detecting behavioural changes in human movement to inform the spatial scale of interventions against COVID-19
On March 23 2020, the UK enacted an intensive, nationwide lockdown to mitigate transmission of COVID-19. As restrictions began to ease,…
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PLOS ONE Understanding and predicting COVID-19 clinical trial completion vs. cessation
As of March 30 2021, over 5,193 COVID-19 clinical trials have been registered through Clinicaltrial.gov. Among them, 191 trials were…
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PLOS Medicine Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study
Background: Development of an effective antiviral drug for Coronavirus Disease 2019 (COVID-19) is a global health priority. Although…
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PLOS ONE Predicting COVID-19 in very large countries: The case of Brazil
This work presents a practical proposal for estimating health system utilization for COVID-19 cases. The novel methodology developed is…
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Image creditFig 1. Timeline of major COVID-19 policy interventions by country. by Woskie et al., CC BY 4.0PLOS ONE Early social distancing policies in Europe, changes in mobility & COVID-19 case trajectories: Insights from Spring 2020
Background: Social distancing have been widely used to mitigate community spread of SARS-CoV-2. We sought to quantify the impact of…
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Image creditFig 2. Number of observations per day. by van Dijk et al., CC BY 4.0PLOS ONE COVID RADAR app: Description and validation of population surveillance of symptoms and behavior in relation to COVID-19
Background: Monitoring of symptoms and behavior may enable prediction of emerging COVID-19 hotspots. The COVID Radar smartphone app, active…
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Image creditFig 1. Geographical representation. by Sharif et al., CC BY 4.0PLOS ONE Detection of SARs-CoV-2 in wastewater using the existing environmental surveillance network: A potential supplementary system for monitoring COVID-19 transmission
The ongoing COVID-19 pandemic is caused by SARs-CoV-2. The virus is transmitted from person to person through droplet infections i.e. when…
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PLOS ONE Contextualising COVID-19 prevention behaviour over time in Australia: Patterns and long-term predictors from April to July 2020 in an online social media sample
Background: In Australia in March 2020 a national public health directive required that non-essential workers stay at home, except for…
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PLOS ONE Designing optimal COVID-19 testing stations locally: A discrete event simulation model applied on a university campus
Providing sufficient testing capacities and accurate results in a time-efficient way are essential to prevent the spread and lower the…
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Image creditFig 5. Proportion of news articles. by Chalkiadakis et al., CC BY 4.0PLOS ONE Infection rate models for COVID-19: Model risk and public health news sentiment exposure adjustments
During the COVID-19 pandemic, governments globally had to impose severe contact restriction measures and social mobility limitations in…
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PLOS ONE Multilevel modeling of county-level excessive alcohol use, rurality, and COVID-19 case fatality rates in the US
Objective: Reports of disparities in COVID-19 mortality rates are emerging in the public health literature as the pandemic continues to…
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PLOS ONE Forecasting daily new infections, deaths and recovery cases due to COVID-19 in Pakistan by using Bayesian Dynamic Linear Models
The COVID-19 has caused the deadliest pandemic around the globe, emerged from the city of Wuhan, China by the end of 2019 and affected all…
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PLOS Computational Biology A network modelling approach to assess non-pharmaceutical disease controls in a worker population: An application to SARS-CoV-2
As part of a concerted pandemic response to protect public health, businesses can enact non-pharmaceutical controls to minimise exposure…
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PLOS ONE Mathematical modeling of the transmission of SARS-CoV-2—Evaluating the impact of isolation in São Paulo State (Brazil) and lockdown in Spain associated with protective measures on the epidemic of CoViD-19
Coronavirus disease 2019 (CoViD-19), with the fatality rate in elder (60 years old or more) being much higher than young (60 years old or…
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PLOS ONE Gravitational scaling analysis on spatial diffusion of COVID-19 in Hubei Province, China
The spatial diffusion of epidemic disease follows distance decay law in geography and social physics, but the mathematical models of…
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PLOS ONE A comparison of prospective space-time scan statistics and spatiotemporal event sequence based clustering for COVID-19 surveillance
The outbreak of the COVID-19 disease was first reported in Wuhan, China, in December 2019. Cases in the United States began appearing in…
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Image creditFig 1. Age and intervention specific contact matrices for Nepal. by Pandey et al., CC BY 4.0PLOS ONE COVID-19 control strategies and intervention effects in resource limited settings: A modeling study
Introduction: Many countries with weaker health systems are struggling to put together a coherent strategy against the COVID-19 epidemic.…
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Image creditFig 2. Illustration of the word2vec model. by Dutta et al., CC BY 4.0PLOS ONE Tracking COVID-19 vaccine hesitancy and logistical challenges: A machine learning approach
In this study, we use an effective word embedding model (word2vec) to systematically track ’vaccine hesitancy’ and ’logistical challenges’…
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Image creditFig 3. Main acceleration indicators—Daily positivity rate (daily cases to daily tests ratio, black line) and average positivity rate (daily cumulated cases to daily cumulated tests ratio, purple line) over time (left panel), and acceleration index (ratio of daily positivity rate to average positivity rate, right panel, blue line) over time, May 13—October 25, 2020. by Baunez et al., CC BY 4.0PLOS ONE Tracking the dynamics and allocating tests for COVID-19 in real-time: An acceleration index with an application to French age groups and départements
An acceleration index is proposed as a novel indicator to track the dynamics of COVID-19 in real-time. Using data on cases and tests in…
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PLOS ONE The evaluation of COVID-19 prediction precision with a Lyapunov-like exponent
In the field of machine learning, building models and measuring their performance are two equally important tasks. Currently, measures of…
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PLOS ONE Causal graph analysis of COVID-19 observational data in German districts reveals effects of determining factors on reported case numbers
Several determinants are suspected to be causal drivers for new cases of COVID-19 infection. Correcting for possible confounders, we…
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Image creditFig 1. Reported daily cases. by Dass et al., CC BY 4.0PLOS ONE A data driven change-point epidemic model for assessing the impact of large gathering and subsequent movement control order on COVID-19 spread in Malaysia
The second wave of COVID-19 in Malaysia is largely attributed to a four-day mass gathering held in Sri Petaling from February 27, 2020,…
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PLOS ONE Effectiveness of containment strategies and local cognition to control vehicular traffic volume in Dhaka, Bangladesh during COVID-19 pandemic: Use of Google Map based real-time traffic data
Background: To prevent the viral transmission from higher infected to lower infected area, controlling the vehicular traffic, consequently…
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Image creditFig 2. IGI FAST testing site workflow. by Ehrenberg et al., CC BY 4.0PLOS ONE Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus
Regular surveillance testing of asymptomatic individuals for SARS-CoV-2 has been center to SARS-CoV-2 outbreak prevention on college and…
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PLOS ONE Evaluating data-driven methods for short-term forecasts of cumulative SARS-CoV2 cases
Background: The WHO announced the epidemic of SARS-CoV2 as a public health emergency of international concern on 30th January 2020. To…
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Image creditFig 5. Effect of latent carriers quarantining. by Proverbio et al., CC BY 4.0PLOS ONE Dynamical SPQEIR model assesses the effectiveness of non-pharmaceutical interventions against COVID-19 epidemic outbreaks
Against the current COVID-19 pandemic, governments worldwide have devised a variety of non-pharmaceutical interventions to mitigate it.…
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Image creditFig 1. The flow of agents through the different SEIRD+M compartments. by Stapelberg et al., CC BY 4.0PLOS ONE A Discrete-Event, Simulated Social Agent-Based Network Transmission (DESSABNeT) model for communicable diseases: Method and validation using SARS-CoV-2 data in three large Australian cities
Importance: During pandemics Agent Based Models (ABMs) can model complex, fine-grained behavioural interactions occurring in social…
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Image creditFig 1. Relative Gini indices for different continents. by Manz and Mansmann, CC BY 4.0PLOS ONE Inequality indices to monitor geographic differences in incidence, mortality and fatality rates over time during the COVID-19 pandemic
Background: It is of interest to explore the variability in how the COVID-19 pandemic evolved geographically during the first twelve…
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PLOS ONE Predicting patients with false negative SARS-CoV-2 testing at hospital admission: A retrospective multi-center study
Importance: False negative SARS-CoV-2 tests can lead to spread of infection in the inpatient setting to other patients and healthcare…
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Image creditFig 1. Directed acrylic graph (DAG). by Sammartino et al., CC BY 4.0PLOS ONE Predictors for inpatient mortality during the first wave of the SARS-CoV-2 pandemic: A retrospective analysis
Background: The coronavirus disease 2019 (COVID-19) pandemic overwhelmed healthcare systems, highlighting the need to better understand…
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PLOS Computational Biology Modelling optimal vaccination strategy for SARS-CoV-2 in the UK
The COVID-19 outbreak has highlighted our vulnerability to novel infections.Faced with this threat and no effective treatment, in line…
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Image creditFig 2. Particle model tuning. by Alexandrou et al., CC BY 4.0PLOS ONE Modeling the evolution of COVID-19 via compartmental and particle-based approaches: Application to the Cyprus case
We present two different approaches for modeling the spread of the COVID-19 pandemic. Both approaches are based on the population classes…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Implementation of a volunteer contact tracing program for COVID-19 in the United States: A qualitative focus group study
Background: Contact tracing is an important tool for suppressing COVID-19 but has been difficult to adapt to the conditions of a public…
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PLOS ONE How well did experts and laypeople forecast the size of the COVID-19 pandemic?
Throughout the COVID-19 pandemic, social and traditional media have disseminated predictions from experts and nonexperts about its…
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Image creditFig 1. Structure of the proposed model. by Zirhumanana Balike Dieudonné, CC BY 4.0PLOS ONE Mathematical model for the mitigation of the economic effects of the Covid-19 in the Democratic Republic of the Congo
Since the apparition of the SRAS-Cov-2 in Wuhan in China, several countries have set diverse measures to stop its spread. Measures…
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PLOS ONE Using control charts to understand community variation in COVID-19
Decision-makers need signals for action as the coronavirus disease 2019 (COVID-19) pandemic progresses. Our aim was to demonstrate a novel…
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Image creditFig 1. COVID-19 in Chile. by Barría-Sandoval et al., CC BY 4.0PLOS ONE Prediction of confirmed cases of and deaths caused by COVID-19 in Chile through time series techniques: A comparative study
Background: Chile has become one of the countries most affected by COVID-19, a pandemic that has generated a large number of cases…
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PLOS ONE Prediction of Covid-19 spreading and optimal coordination of counter-measures: From microscopic to macroscopic models to Pareto fronts
The Covid-19 disease has caused a world-wide pandemic with more than 60 million positive cases and more than 1.4 million deaths by the end…
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PLOS ONE Development of a severity of disease score and classification model by machine learning for hospitalized COVID-19 patients
Background: Efficient and early triage of hospitalized Covid-19 patients to detect those with higher risk of severe disease is essential…
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PLOS ONE The first wave of the SARS-CoV-2 epidemic in Tuscany (Italy): A SI2R2D compartmental model with uncertainty evaluation
With the aim of studying the spread of the SARS-CoV-2 infection in the Tuscany region of Italy during the first epidemic wave…
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Image creditFig 1. Applied study steps for ARIMA and STARIMA model. by Awwad et al., CC BY 4.0PLOS ONE Estimating COVID-19 cases in Makkah region of Saudi Arabia: Space-time ARIMA modeling
The novel coronavirus COVID-19 is spreading across the globe. By 30 Sep 2020, the World Health Organization (WHO) announced that the…
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PLOS ONE Analysis of mobility data to build contact networks for COVID-19
As social distancing policies and recommendations went into effect in response to COVID-19, people made rapid changes to the places they…
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Image creditFig 2. Sri Lanka planning and data collection timeline. by Phadnis et al., CC BY 4.0PLOS ONE Leveraging mobile phone surveys during the COVID-19 pandemic in Ecuador and Sri Lanka: Methods, timeline and findings
Effective and rapid decision making during a pandemic requires data not only about infections, but also about human behavior. Mobile phone…
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Image creditFig 1. Flowchart of patient selection. by Chatterjee et al., CC BY 4.0PLOS ONE Can predicting COVID-19 mortality in a European cohort using only demographic and comorbidity data surpass age-based prediction: An externally validated study
Objective: To establish whether one can build a mortality prediction model for COVID-19 patients based solely on demographics and…
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Image creditFig 1. Schematic of the standard SEIRD epidemiological model. by Eastman et al., CC BY 4.0PLOS ONE Modeling the impact of public response on the COVID-19 pandemic in Ontario
The outbreak of SARS-CoV-2 is thought to have originated in Wuhan, China in late 2019 and has since spread quickly around the world. To…
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PLOS ONE COVID-19: Short term prediction model using daily incidence data
Background: Prediction of the dynamics of new SARS-CoV-2 infections during the current COVID-19 pandemic is critical for public health…
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PLOS ONE Implementation of a COVID-19 surveillance programme for healthcare workers in a teaching hospital in an upper-middle-income country
Introduction: The reporting of Coronavirus Disease 19 (COVID-19) mortality among healthcare workers highlights their vulnerability in…
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Image creditFig 1. Overview of agent-based model. by Ying and O'Clery, CC BY 4.0PLOS ONE Modelling COVID-19 transmission in supermarkets using an agent-based model
Since the outbreak of COVID-19 in early March 2020, supermarkets around the world have implemented different policies to reduce the virus…
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Image creditFig 1. Observed data. by Browning et al., CC BY 4.0PLOS ONE Simple discrete-time self-exciting models can describe complex dynamic processes: A case study of COVID-19
Hawkes processes are a form of self-exciting process that has been used in numerous applications, including neuroscience, seismology, and…
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Image creditFig 1. The SEIR model for the spread of COVID-19 in Lusaka province. by Sichone et al., CC BY 4.0PLOS ONE Assessing required SARS-CoV-2 blanket testing rates for possible control of the outbreak in the epicentre Lusaka province of Zambia with consideration for asymptomatic individuals: A simple mathematical modelling study
Introduction: The novel Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus—2 (SARS-CoV-2), in…
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Image creditFig 2. Simulation settings. by Fiore et al., CC BY 4.0PLOS ONE Containment of COVID-19: Simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation
Efficient contact tracing and testing are fundamental tools to contain the transmission of SARS-CoV-2. We used multi-agent simulations to…
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Image creditFig 2. Death model covariate importance. by Watson et al., CC BY 4.0PLOS Computational Biology Pandemic velocity: Forecasting COVID-19 in the US with a machine learning & Bayesian time series compartmental model
Predictions of COVID-19 case growth and mortality are critical to the decisions of political leaders, businesses, and individuals…
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Image creditFig 1. Schematic illustration of the model framework. by Ling Zhong, CC BY 4.0PLOS ONE A dynamic pandemic model evaluating reopening strategies amid COVID-19
Among over 200 COVID-19 affected countries, some are fighting to “flatten the curve”, while some others are considering reopening after…
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PLOS ONE A statistical analysis of the novel coronavirus (COVID-19) in Italy and Spain
The novel coronavirus (COVID-19) that was first reported at the end of 2019 has impacted almost every aspect of life as we know it. This…
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Image creditFig 2. Detected cases will form the tip of the iceberg. by Johnson et al., CC BY 4.0PLOS ONE In the long shadow of our best intentions: Model-based assessment of the consequences of school reopening during the COVID-19 pandemic
As the world grapples with the ongoing COVID-19 pandemic, a particularly thorny set of questions surrounds the reopening of primary and…
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PLOS Biology A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2
The scientific community is focused on developing antiviral therapies to mitigate the impacts of the ongoing novel coronavirus disease…
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PLOS ONE Development and validation of a predictive model for critical illness in adult patients requiring hospitalization for COVID-19
Background: Identifying factors that can predict severe disease in patients needing hospitalization for COVID-19 is crucial for early…
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PLOS ONE Analysis of the real number of infected people by COVID-19: A system dynamics approach
At the beginning of 2020, the COVID-19 pandemic was able to spread quickly in Wuhan and in the province of Hubei due to a lack of…
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PLOS ONE Impact of mobility restriction in COVID-19 superspreading events using agent-based model
COVID-19 pandemic is an immediate major public health concern. The search for the understanding of the disease spreading made scientists…
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PLOS ONE Space-time covid-19 Bayesian SIR modeling in South Carolina
The Covid-19 pandemic has spread across the world since the beginning of 2020. Many regions have experienced its effects. The state of…
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Image creditFig 1. Risk class per employment sector. by Iavicoli et al., CC BY 4.0PLOS ONE Risk assessment at work and prevention strategies on COVID-19 in Italy
The COVID-19 pandemic has spread worldwide, with considerable public health and socio-economic impacts that are seriously affecting health…
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PLOS ONE Taking account of asymptomatic infections: A modeling study of the COVID-19 outbreak on the Diamond Princess cruise ship
The COVID-19 outbreak on the Diamond Princess (DP) cruise ship has provided empirical data to study the transmission potential of COVID-19…
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PLOS ONE Modelling the impact of interventions on the progress of the COVID-19 outbreak including age segregation
In this work, a SEIR-type mathematical model of the COVID-19 outbreak was developed that describes individuals in compartments by…
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PLOS ONE Predicting fear and perceived health during the COVID-19 pandemic using machine learning: A cross-national longitudinal study
During medical pandemics, protective behaviors need to be motivated by effective communication, where finding predictors of fear and…
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PLOS ONE An epidemic model for non-first-order transmission kinetics
Compartmental models in epidemiology characterize the spread of an infectious disease by formulating ordinary differential equations to…
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Image creditFig 1. Location map of the Pará State, Brazil. by Braga et al., CC BY 4.0PLOS ONE Artificial neural networks for short-term forecasting of cases, deaths, and hospital beds occupancy in the COVID-19 pandemic at the Brazilian Amazon
The first case of the novel coronavirus in Brazil was notified on February 26, 2020. After 21 days, the first case was reported in the…
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PLOS ONE Impact of contact tracing on COVID-19 mortality: An impact evaluation using surveillance data from Colombia
Background: Contact tracing is a crucial part of the public health surveillance toolkit. However, it is labor-intensive and costly to carry…
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PLOS ONE The exposure risk to COVID-19 in most affected countries: A vulnerability assessment model
The world is facing the coronavirus pandemic (COVID-19), which began in China. By August 18, 2020, the United States, Brazil, and India…
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PLOS ONE Development and validation of a predictive model of in-hospital mortality in COVID-19 patients
We retrospectively evaluated 2879 hospitalized COVID-19 patients from four hospitals to evaluate the ability of demographic data, medical…
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PLOS ONE Assessing the likelihood of contracting COVID-19 disease based on a predictive tree model: A retrospective cohort study
Background: Primary care is the major point of access in most health systems in developed countries and therefore for the detection of…
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PLOS ONE Forecasting the spread of SARS-CoV-2 is inherently ambiguous given the current state of virus research
Since the onset of the COVID-19 pandemic many researchers and health advisory institutions have focused on virus spread prediction through…
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PLOS ONE Convolutional neural network model based on radiological images to support COVID-19 diagnosis: Evaluating database biases
As SARS-CoV-2 has spread quickly throughout the world, the scientific community has spent major efforts on better understanding the…
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PLOS ONE Modelling suggests limited change in the reproduction number from reopening Norwegian kindergartens and schools during the COVID-19 pandemic
Background: To suppress the COVID-19 outbreak, the Norwegian government closed all schools on March 13, 2020. The kindergartens reopened on…
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PLOS ONE Forecasting national and regional level intensive care unit bed demand during COVID-19: The case of Italy
Given the pressure on healthcare authorities to assess whether hospital capacity allows properly responding to outbreaks such as COVID-19,…
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Image creditFig 2. AUC under the ROC for composite endpoint in test set. by Mussini et al., CC BY 4.0PLOS ONE Development and validation of a prediction model for tocilizumab failure in hospitalized patients with SARS-CoV-2 infection
Background: The aim of this secondary analysis of the TESEO cohort is to identify, early in the course of treatment with tocilizumab,…
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Image creditFig 3. Daily estimates of CFRs in South Korea. by Kim et al., CC BY 4.0PLOS ONE Estimation of the case fatality rate based on stratification for the COVID-19 outbreak
This work is motivated by the recent worldwide pandemic of the novel coronavirus disease (COVID-19). When an epidemiological disease is…
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Image creditFig 1. A compartmental model for fatal COVID-19 transmission dynamics that incorporates arrival of infected and susceptible individuals and departure of susceptible and/or recovered individuals and incorporates contact tracing and isolation of suspected contacts of infectious individuals. by Mugisha et al., CC BY 4.0PLOS ONE Mathematical modeling of COVID-19 transmission dynamics in Uganda: Implications of complacency and early easing of lockdown
Background: Uganda has a unique set up comprised of resource-constrained economy, social-economic challenges, politically diverse regional…
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PLOS ONE INFEKTA—An agent-based model for transmission of infectious diseases: The COVID-19 case in Bogotá, Colombia
The transmission dynamics of the coronavirus—COVID-19—have challenged humankind at almost every level. Currently, research groups around…
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PLOS ONE Epidemiological model for the inhomogeneous spatial spreading of COVID-19 and other diseases
We suggest a novel mathematical framework for the in-homogeneous spatial spreading of an infectious disease in human population, with…
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Image creditFig 1. The tool graphic user interface. by Kirpich et al., CC BY 4.0PLOS ONE Development of an interactive, agent-based local stochastic model of COVID-19 transmission and evaluation of mitigation strategies illustrated for the state of Massachusetts, USA
Since its discovery in the Hubei province of China, the global spread of the novel coronavirus SARS-CoV-2 has resulted in millions of…
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Image creditFig 3. Disagreement between logarithmic score and WIS. by Bracher et al., CC BY 4.0PLOS Computational Biology Evaluating epidemic forecasts in an interval format
For practical reasons, many forecasts of case, hospitalization, and death counts in the context of the current Coronavirus Disease 2019…
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Image creditFig 1. The flow diagram of the SIQR model. by Zhang et al., CC BY 2.0PLOS ONE Prediction and control of COVID-19 spreading based on a hybrid intelligent model
The coronavirus (COVID-19) is a highly infectious disease that emerged in the late December 2019 in Wuhan, China. It caused a worldwide…
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Image creditFig 1. The interface of the visualization tool. by Németh et al., CC BY 4.0PLOS ONE An open-sourced, web-based application to analyze weekly excess mortality based on the Short-term Mortality Fluctuations data series
The COVID-19 pandemic stimulated the interest of scientists, decision makers and the general public in short-term mortality fluctuations…
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Image creditFig 2. Results of the thematic analysis. by Amann et al., CC BY 4.0PLOS ONE Digital contact-tracing during the Covid-19 pandemic: An analysis of newspaper coverage in Germany, Austria, and Switzerland
Governments around the globe have started to develop and deploy digital contact tracing apps to gain control over the spread of the novel…
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Image creditFig 1. Fever responses as measured by telemetry. by Johnston et al., CC BY 4.0PLOS ONE Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure
Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman…
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PLOS ONE Simulation-based what-if analysis for controlling the spread of Covid-19 in universities
A simulation model is developed to analyze the spread of covid-19 in universities. The model can be used to conduct a what-if analysis and…
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PLOS Computational Biology Estimating the time-varying reproduction number of COVID-19 with a state-space method
After slowing down the spread of the novel coronavirus COVID-19, many countries have started to relax their confinement measures in the…
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PLOS ONE Variational-LSTM autoencoder to forecast the spread of coronavirus across the globe
Modelling the spread of coronavirus globally while learning trends at global and country levels remains crucial for tackling the pandemic.…
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PLOS ONE Modeling the relative risk of SARS-CoV-2 infection to inform risk-cost-benefit analyses of activities during the SARS-CoV-2 pandemic
Risk-cost-benefit analysis requires the enumeration of decision alternatives, their associated outcomes, and the quantification of…
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PLOS ONE An indirect method to monitor the fraction of people ever infected with COVID-19: An application to the United States
The number of COVID-19 infections is key for accurately monitoring the pandemics. However, due to differential testing policies,…
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PLOS ONE Piloting an integrated SARS-CoV-2 testing and data system for outbreak containment among college students: A prospective cohort study
Background: Colleges and universities across the country are struggling to develop strategies for effective control of COVID-19…
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PLOS Computational Biology Predictions of COVID-19 dynamics in the UK: Short-term forecasting and analysis of potential exit strategies
Efforts to suppress transmission of SARS-CoV-2 in the UK have seen non-pharmaceutical interventions being invoked. The most severe…
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PLOS ONE Lessons from movement ecology for the return to work: Modeling contacts and the spread of COVID-19
Human behavior (movement, social contacts) plays a central role in the spread of pathogens like SARS-CoV-2. The rapid spread of SARS-CoV-2…
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PLOS ONE Forecasting hospital demand in metropolitan areas during the current COVID-19 pandemic and estimates of lockdown-induced 2nd waves
We present a forecasting model aim to predict hospital occupancy in metropolitan areas during the current COVID-19 pandemic. Our SEIRD…
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PLOS Computational Biology Modeling the structure of the frameshift-stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformers
The coronavirus causing the COVID-19 pandemic, SARS-CoV-2, uses −1 programmed ribosomal frameshifting (−1 PRF) to control the relative…
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PLOS ONE Model-based forecasting for Canadian COVID-19 data
Background: Since March 11, 2020 when the World Health Organization (WHO) declared the COVID-19 pandemic, the number of infected cases, the…
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PLOS ONE Modeling the initial phase of SARS-CoV-2 deposition in the respiratory tract mimicked by the 11C radionuclide
The knowledge on the deposition and retention of the viral particle of SARS-CoV-2 in the respiratory tract during the very initial intake…
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PLOS ONE Impact of altitude on COVID-19 infection and death in the United States: A modeling and observational study
Background: COVID-19, the disease caused by SARS-CoV-2, has caused a pandemic, sparing few regions. However, limited reports suggest…
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PLOS ONE Predicting in-hospital mortality from Coronavirus Disease 2019: A simple validated app for clinical use
Backgrounds: Validated tools for predicting individual in-hospital mortality of COVID-19 are lacking. We aimed to develop and to validate a…
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PLOS ONE Tracking R of COVID-19: A new real-time estimation using the Kalman filter
We develop a new method for estimating the effective reproduction number of an infectious disease (R) and apply it to track the dynamics…
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PLOS ONE COVID-19: Short-term forecast of ICU beds in times of crisis
By early May 2020, the number of new COVID-19 infections started to increase rapidly in Chile, threatening the ability of health services…
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PLOS ONE Prediction of the COVID-19 epidemic trends based on SEIR and AI models
In December 2019, the outbreak of a new coronavirus-caused pneumonia (COVID-19) in Wuhan attracted close attention in China and the world.…
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PLOS ONE Robust estimation of diagnostic rate and real incidence of COVID-19 for European policymakers
Policymakers need clear, fast assessment of the real spread of the COVID-19 epidemic in each of their respective countries. Standard…
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PLOS ONE The use of health geography modeling to understand early dispersion of COVID-19 in São Paulo, Brazil
Public health policies to contain the spread of COVID-19 rely mainly on non-pharmacological measures. Those measures, especially social…
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PLOS ONE A scientometric overview of CORD-19
As the COVID-19 pandemic unfolds, researchers from all disciplines are coming together and contributing their expertise. CORD-19, a…
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PLOS ONE Forecasting COVID-19 confirmed cases, deaths and recoveries: Revisiting established time series modeling through novel applications for the USA and Italy
The novel coronavirus (COVID-19) is an emergent disease that initially had no historical data to guide scientists on predicting/…
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PLOS ONE Predicting health behavior in response to the coronavirus disease (COVID-19): Worldwide survey results from early March 2020
The current pandemic outbreak of the novel COVID-19, which originated from Wuhan in China in late 2019, has eventually spread to six…
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PLOS ONE Relaxation of social distancing restrictions: Model estimated impact on COVID-19 epidemic in Manitoba, Canada
Objectives: The unprecedented worldwide social distancing response to COVID-19 resulted in a quick reversal of escalating case numbers.…
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PLOS ONE Simple predictive models identify patients with COVID-19 pneumonia and poor prognosis
Background and aims: Identification of SARS-CoV-2-infected patients at high-risk of poor prognosis is crucial. We aimed to establish…
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PLOS ONE Comparison of in-hospital mortality risk prediction models from COVID-19
Objective: Our objective is to compare the predictive accuracy of four recently established outcome models of patients hospitalized with…
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PLOS ONE Spreading of COVID-19: Density matters
Physical distancing has been argued as one of the effective means to combat the spread of COVID-19 before a vaccine or therapeutic drug…
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PLOS ONE Real-time neural network based predictor for cov19 virus spread
Since the epidemic outbreak in early months of 2020 the spread of COVID-19 has grown rapidly in most countries and regions across the…
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PLOS ONE Estimating the herd immunity threshold by accounting for the hidden asymptomatics using a COVID-19 specific model
A quantitative COVID-19 model that incorporates hidden asymptomatic patients is developed, and an analytic solution in parametric form is…
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PLOS Computational Biology Empirical model for short-time prediction of COVID-19 spreading
The appearance and fast spreading of Covid-19 took the international community by surprise. Collaboration between researchers, public…
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PLOS ONE Development and external validation of a prognostic tool for COVID-19 critical disease
Background: The rapid spread of coronavirus disease 2019 (COVID-19) revealed significant constraints in critical care capacity. In…
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PLOS Computational Biology Quantifying the impact of COVID-19 control measures using a Bayesian model of physical distancing
Extensive non-pharmaceutical and physical distancing measures are currently the primary interventions against coronavirus disease 2019…
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PLOS ONE Estimating the real burden of disease under a pandemic situation: The SARS-CoV2 case
The present paper introduces a new model used to study and analyse the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)…
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PLOS ONE Lockdown, relaxation, and acme period in COVID-19: A study of disease dynamics in Hermosillo, Sonora, Mexico
Lockdown and social distancing measures have been implemented for many countries to mitigate the impacts of the COVID-19 pandemic and…
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PLOS ONE COVID-19 healthcare demand projections: Arizona
Beginning in March 2020, the United States emerged as the global epicenter for COVID-19 cases with little to guide policy response in the…
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PLOS ONE Forecasting COVID-19 in Pakistan
Objectives: Forecasting epidemics like COVID-19 is of crucial importance, it will not only help the governments but also, the medical…
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PLOS ONE Modeling and interpreting the COVID-19 intervention strategy of China: A human mobility view
The Coronavirus Disease 2019 (COVID-19) has proved a globally prevalent outbreak since December 2019. As a focused country to alleviate…
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PLOS ONE Testing IgG antibodies against the RBD of SARS-CoV-2 is sufficient and necessary for COVID-19 diagnosis
The COVID-19 pandemic and the fast global spread of the disease resulted in unprecedented decline in world trade and travel. A critical…
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PLOS ONE Kemeny-based testing for COVID-19
Testing, tracking and tracing abilities have been identified as pivotal in helping countries to safely reopen activities after the first…
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PLOS ONE Clinical and molecular characterization of COVID-19 hospitalized patients
Clinical and molecular characterization by Whole Exome Sequencing (WES) is reported in 35 COVID-19 patients attending the University…
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PLOS ONE Analysis of the SARS-CoV-2 epidemic in Italy: The role of local and interventional factors in the control of the epidemic
Containment measures have been applied in several countries in order to limit the diffusion of the SARS-CoV-2 epidemic. The scope of this…
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PLOS Pathogens Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression
The COVID-19 has emerged as an epidemic, causing severe pneumonia with a high infection rate globally. To better understand the…
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PLOS ONE Simulation-free estimation of an individual-based SEIR model for evaluating nonpharmaceutical interventions with an application to COVID-19 in the District of Columbia
The ongoing COVID-19 pandemic has overwhelmingly demonstrated the need to accurately evaluate the effects of implementing new or altering…
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PLOS ONE Forecasting imported COVID-19 cases in South Korea using mobile roaming data
As the number of global coronavirus disease (COVID-19) cases increases, the number of imported cases is gradually rising. Furthermore,…
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PLOS ONE Effect of mitigation measures on the spreading of COVID-19 in hard-hit states in the U.S.
State government-mandated social distancing measures have helped to slow the growth of the COVID-19 pandemic in the United States. Many of…
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PLOS ONE Tracing day-zero and forecasting the COVID-19 outbreak in Lombardy, Italy: A compartmental modelling and numerical optimization approach
Introduction: Italy became the second epicenter of the novel coronavirus disease 2019 (COVID-19) pandemic after China, surpassing by far…
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PLOS ONE Modeling the load of SARS-CoV-2 virus in human expelled particles during coughing and speaking
Particle size is an essential factor when considering the fate and transport of virus-containing droplets expelled by human, because it…
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PLOS ONE A social network model of COVID-19
I construct a dynamic social-network model of the COVID-19 epidemic which embeds the SIR epidemiological model onto a graph of…
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PLOS ONE A discrete-time-evolution model to forecast progress of Covid-19 outbreak
Here we present a discrete-time-evolution model with one day interval to forecast the propagation of Covid-19. The proposed model can be…
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PLOS ONE The first 2 months of the SARS-CoV-2 epidemic in Yemen: Analysis of the surveillance data
Introduction: Yemen was one of the last countries in the world to declare the first case of the pandemic, on 10 April 2020. Fear and…
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PLOS ONE Monitoring physical distancing for crowd management: Real-time trajectory and group analysis
Physical distancing, as a measure to contain the spreading of Covid-19, is defining a “new normal”. Unless belonging to a family,…
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PLOS ONE Country-level pandemic risk and preparedness classification based on COVID-19 data: A machine learning approach
In this work we present a three-stage Machine Learning strategy to country-level risk classification based on countries that are reporting…
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PLOS ONE Modeling and prediction of the 2019 coronavirus disease spreading in China incorporating human migration data
This study integrates the daily intercity migration data with the classic Susceptible-Exposed-Infected-Removed (SEIR) model to construct a…
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PLOS ONE Assessing concerns for the economic consequence of the COVID-19 response and mental health problems associated with economic vulnerability and negative economic shock in Italy, Spain, and the United Kingdom
Many different countries have been under lockdown or extreme social distancing measures to control the spread of COVID-19. The potentially…
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PLOS ONE A mathematical model of COVID-19 transmission in a tertiary hospital and assessment of the effects of different intervention strategies
Novel coronavirus (named SARS-CoV-2) can spread widely in confined settings including hospitals, cruise ships, prisons, and places of…
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PLOS ONE Game analysis on the evolution of COVID-19 epidemic under the prevention and control measures of the government
In this paper, the interaction strategies and the evolutionary game analysis of the actions taken by the government and the public in the…
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PLOS ONE Modeling latent infection transmissions through biosocial stochastic dynamics
The events of the recent SARS-CoV-2 epidemics have shown the importance of social factors, especially given the large number of…
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PLOS ONE The impact of lockdown enforcement during the SARSCoV-2 pandemic on the timing of presentation and early outcomes of patients with ST-elevation myocardial infarction
Introduction: Early reports described decreased admissions for acute cardiovascular events during the SarsCoV-2 pandemic. We aimed to…
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PLOS Neglected Tropical Diseases Identifying the outbreak signal of COVID-19 before the response of the traditional disease monitoring system
Molecular and Genetic Studies
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PLOS Computational Biology Viral surface geometry shapes influenza and coronavirus spike evolution through antibody pressure
The evolution of circulating viruses is shaped by their need to evade antibody response, which mainly targets the viral spike. Because of…
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PLOS Computational Biology Epitope profiling using computational structural modelling demonstrated on coronavirus-binding antibodies
Identifying the epitope of an antibody is a key step in understanding its function and its potential as a therapeutic. Sequence-based…
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PLOS ONE Local occurrence and fast spread of B.1.1.7 lineage: A glimpse into Friuli Venezia Giulia
In-depth study of the entire SARS-CoV-2 genome has uncovered many mutations, which have replaced the lineage that characterized the first…
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PLOS ONE Development of an efficient Sanger sequencing-based assay for detecting SARS-CoV-2 spike mutations
Novel strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harboring nucleotide changes (mutations) in the spike gene…
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PLOS ONE Reconstructing SARS-CoV-2 infection dynamics through the phylogenetic inference of unsampled sources of infection
The COVID-19 pandemic has illustrated the importance of infection tracking. The role of asymptomatic, undiagnosed individuals in driving…
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PLOS ONE Spatial epidemiology and genetic diversity of SARS-CoV-2 and related coronaviruses in domestic and wild animals
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) showed susceptibility to diverse animal species. We conducted this study…
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PLOS Pathogens A vesicular stomatitis virus-based prime-boost vaccination strategy induces potent and protective neutralizing antibodies against SARS-CoV-2
The development of safe and effective vaccines to prevent SARS-CoV-2 infections remains an urgent priority worldwide. We have used a…
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PLOS Biology Evolutionary pathways to SARS-CoV-2 resistance are opened and closed by epistasis acting on ACE2
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects a broader range of mammalian species than previously predicted,…
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PLOS ONE SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease
SARS-CoV-2 infection elicits a robust B cell response, resulting in the generation of long-lived plasma cells and memory B cells. Here, we…
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PLOS ONE Chimeric crRNA improves CRISPR–Cas12a specificity in the N501Y mutation detection of Alpha, Beta, Gamma, and Mu variants of SARS-CoV-2
Many CRISPR/Cas platforms have been established for the detection of SARS-CoV-2. But the detection platform of the variants of SARS-CoV-2…
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PLOS Computational Biology Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection
A key question in SARS-CoV-2 infection is why viral loads and patient outcomes vary dramatically across individuals. Because…
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PLOS Pathogens Longitudinal dynamics of SARS-CoV-2-specific cellular and humoral immunity after natural infection or BNT162b2 vaccination
The timing of the development of specific adaptive immunity after natural SARS-CoV-2 infection, and its relevance in clinical outcome, has…
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PLOS Biology A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets
Over the past 20 years, 3 highly pathogenic human coronaviruses (HCoVs) have emerged—Severe Acute Respiratory Syndrome Coronavirus…
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PLOS Pathogens Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals
Class II tetramer reagents for eleven common DR alleles and a DP allele prevalent in the world population were used to identify SARS-CoV-2…
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PLOS ONE IgG3 and IgM Identified as Key to SARS-CoV-2 Neutralization in Convalescent Plasma Pools
Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2…
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PLOS ONE Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19
Background: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can manifest…
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PLOS Pathogens Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19
COVID-19 displays diverse disease severities and symptoms including acute systemic inflammation and hypercytokinemia, with subsequent…
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PLOS ONE Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis
Hyperactive and damaging inflammation is a hallmark of severe rather than mild Coronavirus disease 2019 (COVID-19). To uncover key…
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PLOS ONE Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease
Based on previous large-scale in silico screening several factor Xa inhibitors were proposed to potentially inhibit SARS-CoV-2 Mpro. In…
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PLOS Pathogens Structure-guided antibody cocktail for prevention and treatment of COVID-19
Development of effective therapeutics for mitigating the COVID-19 pandemic is a pressing global need. Neutralizing antibodies are known to…
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PLOS Pathogens Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma
The global SARS-CoV-2 coronavirus pandemic continues to be devastating in many areas. Treatment options have been limited and convalescent…
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PLOS ONE Nanopore sequencing of SARS-CoV-2: Comparison of short and long PCR-tiling amplicon protocols
Surveillance of the SARS-CoV-2 variants including the quickly spreading mutants by rapid and near real-time sequencing of the viral genome…
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PLOS Biology Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge
The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a pandemic causing significant damage to…
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PLOS Pathogens Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption
COVID-19 patients transmitted SARS-CoV-2 to minks in the Netherlands in April 2020. Subsequently, the mink-associated virus (miSARS-CoV-2)…
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PLOS ONE Targeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens
The rapid, sensitive and specific detection of SARS-CoV-2 is critical in responding to the current COVID-19 outbreak. In this…
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PLOS Neglected Tropical Diseases Seroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020
Background: While Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have been conducted there…
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PLOS Pathogens An outbreak of SARS-CoV-2 with high mortality in mink (Neovison vison) on multiple Utah farms
The breadth of animal hosts that are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and may serve as…
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PLOS Pathogens Infection, recovery and re-infection of farmed mink with SARS-CoV-2
Mink, on a farm with about 15,000 animals, became infected with SARS-CoV-2. Over 75% of tested animals were positive for SARS-CoV-2 RNA in…
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PLOS ONE Mesenchymal stromal cell-derived extracellular vesicles reduce lung inflammation and damage in nonclinical acute lung injury: Implications for COVID-19
Mesenchymal stem cell derived extracellular vesicles (MSC-EVs) are bioactive particles that evoke beneficial responses in recipient cells.…
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PLOS ONE Immunoinformatics mapping of potential epitopes in SARS-CoV-2 structural proteins
All approved coronavirus disease 2019 (COVID-19) vaccines in current use are safe, effective, and reduce the risk of severe illness.…
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PLOS ONE Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection
Background: Coronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to…
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PLOS ONE Recombinant production of a functional SARS-CoV-2 spike receptor binding domain in the green algae Chlamydomonas reinhardtii
Recombinant production of viral proteins can be used to produce vaccine antigens or reagents to identify antibodies in patient serum.…
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PLOS ONE Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction
SARS-CoV-2 viral attachment and entry into host cells is mediated by a direct interaction between viral spike glycoproteins and membrane…
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PLOS Computational Biology Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections
Severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is of zoonotic origin. Evolutionary analyses…
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PLOS ONE Nanopore metagenomic sequencing for detection and characterization of SARS-CoV-2 in clinical samples
Objectives: The COVID-19 pandemic has underscored the need for rapid novel diagnostic strategies. Metagenomic Next-Generation Sequencing…
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PLOS Pathogens Phosphatidylserine receptors enhance SARS-CoV-2 infection
Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through virion-associated PS binding that is termed…
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PLOS Pathogens TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction
Interferons play a critical role in regulating host immune responses to SARS-CoV-2, but the interferon (IFN)-stimulated gene (ISG)…
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PLOS ONE Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: A bioinformatics and experimental study
Acute lung injury (ALI) is a specific form of lung damage caused by different infectious and non-infectious agents, including SARS-CoV-2,…
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PLOS ONE Detection of cross-reactive immunoglobulin A against the severe acute respiratory syndrome-coronavirus-2 spike 1 subunit in saliva
Abundant secretory immunoglobulin A (SIgA) in the mucus, breast milk, and saliva provides immunity against infection of mucosal surfaces.…
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PLOS ONE Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate
The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the…
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PLOS ONE Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates
Due to the widespread of the COVID-19 pandemic, the SARS-CoV-2 genome is evolving in diverse human populations. Several studies already…
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Image creditCruise Ships at Dock by Public Domain, CC 0PLOS ONE Performance of anti-SARS-CoV-2 antibody testing in asymptomatic or mild COVID-19 patients: A retrospective study in outbreak on a cruise ship
Objectives: A few studies on antibody testing have focused on asymptomatic or mild coronavirus disease 2019 (COVID-19) patients with low…
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Image creditSARS-CoV-2 by Public Domain, CC 0PLOS ONE Identifying key determinants and dynamics of SARS-CoV-2/ACE2 tight interaction
SARS-CoV-2 virus, the causative agent of Covid-19, has fired up a global pandemic. The virus interacts with the human receptor…
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PLOS ONE Wave-wise comparative genomic study for revealing the complete scenario and dynamic nature of COVID-19 pandemic in Bangladesh
As the COVID-19 pandemic continues to ravage across the globe and take millions of lives and like many parts of the world, the second wave…
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PLOS ONE Local topology and bifurcation hot-spots in proteins with SARS-CoV-2 spike protein as an example
Novel topological methods are introduced to protein research. The aim is to identify hot-spot sites where a bifurcation can alter the…
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PLOS Pathogens The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation
Viral proteins localize within subcellular compartments to subvert host machinery and promote pathogenesis. To study SARS-CoV-2 biology,…
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PLOS Medicine Different dose regimens of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373) in younger and older adults: A phase 2 randomized placebo-controlled trial
Background: NVX-CoV2373 is a recombinant severe acute respiratory coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric…
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Image credit3D print of a SARS-CoV-2—also known as 2019-nCoV by Public Domain, CC 0PLOS ONE Humoral response after SARS-CoV-2 mRNA vaccines in dialysis patients: Integrating anti-SARS-CoV-2 Spike-Protein-RBD antibody monitoring to manage dialysis centers in pandemic times
Dialysis patients are both the most likely to benefit from vaccine protection against SARS-CoV-2 and at the highest risk of not developing…
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PLOS Pathogens Impaired function and delayed regeneration of dendritic cells in COVID-19
Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in…
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PLOS Biology SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a pandemic that…
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PLOS ONE SARS-CoV-2 viral load as a predictor for disease severity in outpatients and hospitalised patients with COVID-19: A prospective cohort study
Introduction: We aimed to examine if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) cycle…
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PLOS Neglected Tropical Diseases Genomic surveillance of SARS-CoV-2 tracks early interstate transmission of P.1 lineage and diversification within P.2 clade in Brazil
The sharp increase of COVID-19 cases in late 2020 has made Brazil the new epicenter of the ongoing SARS-CoV-2 pandemic. The novel viral…
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PLOS Pathogens Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the disease COVID-19 can lead to serious symptoms, such as…
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PLOS Pathogens Cross-neutralization of SARS-CoV-2 by HIV-1 specific broadly neutralizing antibodies and polyclonal plasma
Cross-reactive epitopes (CREs) are similar epitopes on viruses that are recognized or neutralized by same antibodies. The S protein of…
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Image creditTest tubes and Erlenmeyer flask by Jernej Furman, CC BY 2.0PLOS ONE Validation of conventional PCR-like alternative to SARS-CoV-2 detection with target nucleocapsid protein gene in naso-oropharyngeal samples
SARS-CoV-2 has spread worldwide and has become a global health problem. As a result, the demand for inputs for diagnostic tests rose…
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Image creditFig 5. Post-challenge immune responses by Rosati et al., CC BY 4.0PLOS Pathogens Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques
The speed of development, versatility and efficacy of mRNA-based vaccines have been amply demonstrated in the case of SARS-CoV-2. DNA…
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PLOS ONE Does reactogenicity after a second injection of the BNT162b2 vaccine predict spike IgG antibody levels in healthy Japanese subjects?
Background: Adverse reactions are more common after the second injection of messenger RNA vaccines such as Pfizer/BioNTech’s BNT162b2. We…
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PLOS ONE The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro
SARS-CoV-2 enters host cells when the viral spike protein is cleaved by transmembrane protease serine 2 (TMPRSS2) after binding to the…
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Image creditFig 2. Common mutations in partial RDV resistance populations by Szemiel et al., CC BY 4.0PLOS Pathogens In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2
Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small molecule antiviral for the treatment of COVID-19…
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PLOS Pathogens Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19
The aim of this study was to define the breadth and specificity of dominant SARS-CoV-2-specific T cell epitopes using a comprehensive set…
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PLOS ONE Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation
There is a worldwide need for reagents to perform SARS-CoV-2 detection. Some laboratories have implemented kit-free protocols, but many…
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Image creditFig 1. Serum reactivity of COVID-19 patients and pre-pandemic controls at each ELISA. by de la Guardia et al., CC BY 4.0PLOS ONE Development of in-house, indirect ELISAs for the detection of SARS-CoV-2 spike protein-associated serology in COVID-19 patients in Panama
COVID-19 is the name of the acute respiratory disease caused by the new coronavirus SARS-CoV-2, a close relative of those that caused the…
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PLOS Computational Biology Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2
Apart from the canonical fingers, palm and thumb domains, the RNA dependent RNA polymerases (RdRp) from the viral order Nidovirales…
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Image creditFig 2. Linear epitope mapping of spike protein in mRNA vaccine recipients by Wisnewski et al., CC BY 4.0PLOS ONE Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines
Reverse vaccinology is an evolving approach for improving vaccine effectiveness and minimizing adverse responses by limiting immunizations…
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Image creditFig 1. Generation and characterization of v-NY-S and MVA-S by Kulkarni et al., CC BY 4.0PLOS ONE Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters
COVID-19 in humans is caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that belongs to the beta family of…
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PLOS Pathogens Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells
COVID-19 vaccines based on the Spike protein of SARS-CoV-2 have been developed that appear to be largely successful in stopping infection.…
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PLOS Computational Biology Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants
The SARS-CoV-2 pandemic highlights the need for a detailed molecular understanding of protective antibody responses. This is underscored…
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PLOS Pathogens Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection
The key to battling the COVID-19 pandemic and its potential aftermath is to develop a variety of vaccines that are efficacious and safe,…
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Image creditFig 6. Characteristic pathological findings of SARS-CoV-2 infection in minks by Chaintoutis et al., CC BY 4.0PLOS Pathogens Outbreaks of SARS-CoV-2 in naturally infected mink farms: Impact, transmission dynamics, genetic patterns, and environmental contamination
SARS-CoV-2 infection outbreaks in minks have serious implications associated with animal health and welfare, and public health. In two…
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PLOS ONE Development of ACE2 autoantibodies after SARS-CoV-2 infection
Background: Activation of the immune system is implicated in the Post-Acute Sequelae after SARS-CoV-2 infection (PASC) but the mechanisms…
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Image creditFig 4. PheWAS associations for COVID-19 susceptibility in HES data by Papadopoulou et al., CC BY 4.0PLOS ONE COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases
Epidemiological studies suggest that individuals with comorbid conditions including diabetes, chronic lung, inflammatory and vascular…
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PLOS Pathogens Ethacridine inhibits SARS-CoV-2 by inactivating viral particles
The respiratory disease COVID-19 is caused by the coronavirus SARS-CoV-2. Here we report the discovery of ethacridine as a potent drug…
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Image creditFig 1. Neutrophils and G-MDSCs during COVID-19 by Peñaloza et al., CC BY 4.0PLOS Pathogens Neutrophils and lymphopenia, an unknown axis in severe COVID-19 disease
The Coronavirus Disease 2019 (COVID-19) is caused by the betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)…
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PLOS Pathogens Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection
SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key role in preventing coronavirus disease 2019…
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PLOS ONE Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences
The SARS-CoV-2 disease, first detected in Wuhan, China, in December 2019 has become a global pandemic and is causing an unprecedented…
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PLOS ONE Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan
Background: We investigated the genome diversity of SARS-CoV-2 associated with the early COVID-19 period to investigate evolution of the…
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Image creditFig 2. Comparison of CoV tropism by Vu et al., CC BY 4.0PLOS Pathogens Binding and entering: COVID finds a new home
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory…
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PLOS ONE Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel
Background: Countries across the globe have mobilized their armed forces in response to COVID-19, placing them at increased risk for viral…
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Image creditDifferential metabolites involved in sepsis associated to COVID-19 infection by Herrera-Van Oostdam et al., CC BY 4.0PLOS ONE Immunometabolic signatures predict risk of progression to sepsis in COVID-19
Viral sepsis has been proposed as an accurate term to describe all multisystemic dysregulations and clinical findings in severe and…
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PLOS ONE Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection
Background: The effects of pre-existing endemic human coronavirus (HCoV) immunity on SARS-CoV-2 serologic and clinical responses are…
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PLOS Pathogens SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon
Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral infection. Resultantly, many viruses…
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Image creditFig 2. Sequence data by Doddapaneni et al., CC BY 4.0PLOS ONE Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals
The newly emerged and rapidly spreading SARS-CoV-2 causes coronavirus disease 2019 (COVID-19). To facilitate a deeper understanding of the…
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PLOS ONE Differential impact of the COVID-19 pandemic on laboratory reporting of norovirus and Campylobacter in England: A modelling approach
Background: The COVID-19 pandemic has impacted surveillance activities for multiple pathogens. Since March 2020, there was a decline in the…
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Image creditTest tubes on white background by Jernej Furman, CC BY 2.0PLOS ONE Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?
Torquetenovirus (TTV) is present in biological fluids from healthy individuals and measurement of its titer is used to assess immune…
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PLOS Pathogens Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks
The emergence of divergent SARS-CoV-2 lineages has raised concern that novel variants eliciting immune escape or the ability to displace…
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PLOS ONE Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L
SARS-CoV-2 requires serine protease, transmembrane serine protease 2 (TMPRSS2), and cysteine proteases, cathepsins B, L (CTSB/L) for entry…
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Image creditFig 3. Triple-labeling show viral replication by Jansen et al., CC BY 4.0PLOS ONE Direct detection of SARS-CoV-2 antisense and sense genomic RNA in human saliva by semi-autonomous fluorescence in situ hybridization: A proxy for contagiousness?
Saliva is a matrix which may act as a vector for pathogen transmission and may serve as a possible proxy for SARS-CoV-2 contagiousness.…
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PLOS ONE Plant-produced SARS-CoV-2 receptor binding domain (RBD) variants showed differential binding efficiency with anti-spike specific monoclonal antibodies
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the ongoing coronavirus disease (COVID-19) pandemic which…
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PLOS ONE Longitudinal analysis to characterize classes and subclasses of antibody responses to recombinant receptor-binding protein (RBD) of SARS-CoV-2 in COVID-19 patients in Thailand
Serological assays to detect antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might contribute to…
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Image creditFig 1. Domains of the Spike protein by Teruel et al., CC BY 4.0PLOS Computational Biology Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants
The SARS-CoV-2 Spike protein needs to be in an open-state conformation to interact with ACE2 to initiate viral entry. We utilise…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, Public Domain 1.0PLOS ONE Natural killer-cell immunoglobulin-like receptors trigger differences in immune response to SARS-CoV-2 infection
Background: The diversity in the clinical course of COVID-19 has been related to differences in innate and adaptative immune response…
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Image creditFig 1. Ct values per days post diagnosis by Zuckerman et al., CC BY 4.0PLOS ONE Prolonged detection of complete viral genomes demonstrated by SARS-CoV-2 sequencing of serial respiratory specimens
Accurate and timely diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is clinically essential, and is required…
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Image creditFig 1. Location of the mutations in spike tested in this work by Alenquer et al., CC BY 4.0PLOS Pathogens Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies
Understanding SARS-CoV-2 evolution and host immunity is critical to control COVID-19 pandemics. At the core is an arms-race between…
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PLOS ONE Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies
The SARS-CoV-2 pandemic is a major global threat that sparked global research efforts. Pre-clinical and biochemical SARS-CoV-2 studies…
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PLOS ONE Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodies
Serologic assays developed for SARS-CoV-2 detect different antibody subtypes and are based on different target antigens. Comparison of the…
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PLOS Pathogens Altered microRNA expression in COVID-19 patients enables identification of SARS-CoV-2 infection
The host response to SARS-CoV-2 infection provide insights into both viral pathogenesis and patient management. The host-encoded microRNA…
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PLOS ONE Predicting the efficacy of COVID-19 convalescent plasma donor units with the Lumit Dx anti-receptor binding domain assay
Background: The novel coronavirus SARS-CoV2 that causes COVID-19 has resulted in the death of more than 2.5 million people, but no cure…
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PLOS ONE Unified platform for genetic and serological detection of COVID-19 with single-molecule technology
The COVID-19 pandemic raises the need for diverse diagnostic approaches to rapidly detect different stages of viral infection. The…
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PLOS ONE SARS-CoV-2 variant evolution in the United States: High accumulation of viral mutations over time likely through serial Founder Events and mutational bursts
Since the first case of COVID-19 in December 2019 in Wuhan, China, SARS-CoV-2 has spread worldwide and within a year and a half has caused…
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Image creditIFig 2. Comparison of Nsp3 and PLpro interactome by Armstrong et al., CC BY 4.0PLOS ONE Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and plays important roles in the viral life cycle.…
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Image creditFig 1. Improved cell engineering platform expressing human ACE2 by Shukla et al., CC BY 4.0PLOS Pathogens Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection
SARS-CoV and SARS-CoV-2 encode spike proteins that bind human ACE2 on the cell surface to enter target cells during infection. A small…
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PLOS Pathogens SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescence
T-cell immunity is likely to play a role in protection against SARS-CoV-2 by helping generate neutralizing antibodies. We longitudinally…
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Image creditFig 1. ACE2 Decoy Receptor Engineering by Sims et al., CC BY 4.0PLOS Pathogens Intranasal gene therapy to prevent infection by SARS-CoV-2 variants
SARS-CoV-2 variants have emerged with enhanced pathogenicity and transmissibility, and escape from pre-existing immunity, suggesting…
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PLOS Pathogens SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney
COVID-19 (coronavirus disease 2019) caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is a disease…
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PLOS Biology Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies
SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level persistent viral RNA…
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PLOS Neglected Tropical Diseases Prevalence of neutralising antibodies against SARS-CoV-2 in acute infection and convalescence: A systematic review and meta-analysis
Background: Individuals infected with SARS-CoV-2 develop neutralising antibodies. We investigated the proportion of individuals with…
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PLOS Medicine SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral…
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Image creditFig 6. Reduced pulmonary lesions in mAb-treated animals. by . Van Rompay et al., CC BY 4.0PLOS Pathogens Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques
There is an urgent need for effective therapeutic interventions against SARS-CoV-2, including new variants that continue to arise.…
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Image creditFig 1. The number of circulating LDGs increases in acute COVID-19. by Cabrera et al., CC BY 4.0PLOS Pathogens Characterization of low-density granulocytes in COVID-19
Severe COVID-19 is characterized by extensive pulmonary complications, to which host immune responses are believed to play a role. As the…
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PLOS Pathogens ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions
SARS-CoV-2 uses the human ACE2 (hACE2) receptor for cell attachment and entry, with mouse ACE2 (mACE2) unable to support infection. Herein…
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PLOS ONE Development and validation of a quantitative, non-invasive, highly sensitive and specific, electrochemical assay for anti-SARS-CoV-2 IgG antibodies in saliva
Amperial™ is a novel assay platform that uses immobilized antigen in a conducting polymer gel followed by detection via electrochemical…
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PLOS ONE Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform
L-Dopa decarboxylase (DDC) is the most significantly co-expressed gene with ACE2, which encodes for the SARS-CoV-2 receptor…
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Image creditFig 2. Permissivity genes are associated to viral related processes and correlated to viral expression. by Ramirez Alvarez et al., CC BY 4.0PLOS Pathogens The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity
COVID-19 outbreak is the biggest threat to human health in recent history. Currently, there are over 1.5 million related deaths and 75…
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PLOS ONE SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating global pandemic, infecting over 43 million people…
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PLOS Pathogens Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2
COVID-19 is a global crisis of unimagined dimensions. Currently, Remedesivir is only fully licensed FDA therapeutic. A major target of the…
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PLOS ONE The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19, little is known about their mechanism(s) of…
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PLOS ONE SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19
The unprecedented global COVID-19 pandemic has prompted a desperate international effort to accelerate the development of anti-viral…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Performance of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies in South Africa
Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) has been identified as the causative agent for causing the clinical syndrome…
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PLOS ONE The human microbiome and COVID-19: A systematic review
Background: Human microbiotas are communities of microorganisms living in symbiosis with humans. They play an important role in the host…
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PLOS ONE Comparative performance and cycle threshold values of 10 nucleic acid amplification tests for SARS-CoV-2 on clinical samples
Background: A number of nucleic acid amplification tests (NAATs) for SARS-CoV-2 with different reagents have been approved for clinical use…
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PLOS Pathogens Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing
Coronavirus Disease 2019 (COVID-19), caused by a new strain of coronavirus called Severe Acute Respiratory Syndrome Coronavirus 2…
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Image creditFig 1. Patients and controls show reactivity to a poliovirus control. by Heffron et al., CC BY 4.0PLOS Biology The landscape of antibody binding in SARS-CoV-2 infection
The search for potential antibody-based diagnostics, vaccines, and therapeutics for pandemic severe acute respiratory syndrome coronavirus…
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PLOS ONE Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions
In the pursuit of suitable and effective solutions to SARS-CoV-2 infection, we investigated the efficacy of several phenolic compounds in…
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Image creditFig 1. Ribosome profiling reveals the unfolded protein response as a key pathway in the host response to MHV-A59 infection. by Echavarría-Consuegra et al., CC BY 4.0PLOS Pathogens Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection
Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by…
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PLOS ONE Human IgG and IgA responses to COVID-19 mRNA vaccines
SARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral neutralization and are likely an important component of…
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Image creditFig 1. Sampling sites map. by Kumakamba et al., CC BY 4.0PLOS ONE Coronavirus surveillance in wildlife from two Congo basin countries detects RNA of multiple species circulating in bats and rodents
Coronaviruses play an important role as pathogens of humans and animals, and the emergence of epidemics like SARS, MERS and COVID-19 is…
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Image creditFig 2. Screening array of GST-PDZ domain fusion proteins. by Shepley-McTaggart et al., CC BY 4.0PLOS ONE SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1
Newly emerged SARS-CoV-2 is the cause of an ongoing global pandemic leading to severe respiratory disease in humans. SARS-CoV-2 targets…
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PLOS ONE Potential G-quadruplexes and i-Motifs in the SARS-CoV-2
Quadruplex structures have been identified in a plethora of organisms where they play important functions in the regulation of molecular…
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PLOS ONE Development of an efficient one-step real-time reverse transcription polymerase chain reaction method for severe acute respiratory syndrome-coronavirus-2 detection
The general methods to detect the RNA of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in clinical diagnostic testing…
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PLOS Medicine Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study
Background: Increased vitamin D levels, as reflected by 25-hydroxy vitamin D (25OHD) measurements, have been proposed to protect against…
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PLOS Neglected Tropical Diseases DNA vaccination induced protective immunity against SARS CoV-2 infection in hamsterss
The development of efficient vaccines against COVID-19 is an emergent need for global public health. The spike protein of severe acute…
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Image creditFig 2. TMEM41B is essential for the replication of multiple coronaviruses. by Trimarco et al., CC BY 4.0PLOS Pathogens TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2
Antiviral therapeutics are a front-line defense against virally induced diseases. Because viruses frequently mutate to escape direct…
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Image creditFig 2. Best docking poses for tested proteins. by Baysal et al., CC BY 4.0PLOS ONE Molecular dynamics analysis of N-acetyl-D-glucosamine against specific SARS-CoV-2’s pathogenicity factors
The causative agent of the pandemic identified as SARS-CoV-2 leads to a severe respiratory illness similar to SARS and MERS with fever,…
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PLOS ONE Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants’ spike protein–an in silico analysis
Two SARS-CoV-2 variants of concern showing increased transmissibility relative to the Wuhan virus have recently been identified. Although…
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Image creditFig 1. Production and optimization of spike protein. by Thépaut et al., CC BY 4.0PLOS Pathogens DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist
The efficient spread of SARS-CoV-2 resulted in a unique pandemic in modern history. Despite early identification of ACE2 as the receptor…
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PLOS ONE Testing of four-sample pools offers resource optimization without compromising diagnostic performance of real time reverse transcriptase-PCR assay for COVID-19
Quick identification and isolation of SARS-CoV-2 infected individuals is central to managing the COVID-19 pandemic. Real time reverse…
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PLOS Pathogens Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity
SARS-CoV-2 is the novel coronavirus that is the causative agent of COVID-19, a sometimes-lethal respiratory infection responsible for a…
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Image creditFig 1. Structure of RdRP of SARS-CoV-2. by Koulgi et al., CC BY 4.0PLOS ONE Natural plant products as potential inhibitors of RNA dependent RNA polymerase of Severe Acute Respiratory Syndrome Coronavirus-2
Drug repurposing studies targeting inhibition of RNA dependent RNA polymerase (RdRP) of Severe Acute Respiratory Syndrome Coronavirus 2…
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PLOS Biology Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens…
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PLOS Biology Multiplex qPCR discriminates variants of concern to enhance global surveillance of SARS-CoV-2
With the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants that may increase transmissibility and/or…
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PLOS Biology Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
The recently reported “UK variant” (B.1.1.7) of SARS-CoV-2 is thought to be more infectious than previously circulating strains as a…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Analysis of cytokines in SARS-CoV-2 or COVID-19 patients in Erbil city, Kurdistan Region of Iraq
The emergence of the novel coronavirus and then pandemic outbreak was coined 2019- nCoV or COVID-19 (or SARS-CoV-2 disease 2019). This…
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PLOS ONE Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli
To stop the COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which caused more than 2.5 million…
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PLOS ONE Development of multiplex real-time RT-PCR assay for the detection of SARS-CoV-2
The outbreak of the new human coronavirus SARS-CoV-2 (also known as 2019-nCoV) continues to increase globally. The real-time reverse…
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Image creditFig 1. Single-cell resolution of SARS-CoV-2 infection. by Gallagher and McCray Jr., CC BY 4.0PLOS Biology The first few days of a SARS-CoV-2 infection viewed at single-cell resolution
What transpires soon after inhaling Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the respiratory virus causing…
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PLOS Pathogens The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways
The high transmissibility of SARS-CoV-2 is related to abundant replication in the upper airways, which is not observed for the other…
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Image creditFig 1. Design and expression of minispike. by Hennrich et al., CC BY 4.0PLOS Pathogens Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization
Vaccines of outstanding efficiency, safety, and public acceptance are needed to halt the current SARS-CoV-2 pandemic. Concerns include…
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Image creditFig 3. Random forest host predictions based on coronavirus genome composition. by Brierley and Fowler, CC BY 4.0PLOS Pathogens Predicting the animal hosts of coronaviruses from compositional biases of spike protein and whole genome sequences through machine learning
The COVID-19 pandemic has demonstrated the serious potential for novel zoonotic coronaviruses to emerge and cause major outbreaks. The…
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PLOS Computational Biology Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection
The COVID-19 pandemic is posing an unprecedented threat to the whole world. In this regard, it is absolutely imperative to understand the…
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PLOS Pathogens Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates infection of cells expressing…
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PLOS Pathogens High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19
Tracking evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within infected individuals will help elucidate…
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Image creditFig 1. Spikes used in this study. by Eguia et al., CC BY 4.0PLOS Pathogens A human coronavirus evolves antigenically to escape antibody immunity
There is intense interest in antibody immunity to coronaviruses. However, it is unknown if coronaviruses evolve to escape such immunity,…
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Image creditFig 2. Correlation between ELISA and Joinstar values. by Mellhammar et al., CC BY 4.0PLOS ONE Heparin binding protein in severe COVID-19—A prospective observational cohort study
Background and aims: Neutrophil-derived heparin binding protein (HBP; also known as azurocidin or CAP-37) is a key player in bacterial…
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PLOS Computational Biology Computational epitope map of SARS-CoV-2 spike protein
The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein. S is exposed on the viral surface and mediates…
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PLOS Pathogens Viral genomic, metagenomic and human transcriptomic characterization and prediction of the clinical forms of COVID-19
COVID-19 is characterized by respiratory symptoms of various severities, ranging from mild upper respiratory signs to acute respiratory…
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PLOS Biology SARS-CoV-2 variants reveal features critical for replication in primary human cells
Since entering the human population, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2; the causative agent of Coronavirus…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID/NIH, CC-0 Public DomainPLOS ONE A faster and less costly alternative for RNA extraction of SARS-CoV-2 using proteinase k treatment followed by thermal shock
One of the biggest challenges during the pandemic has been obtaining and maintaining critical material to conduct the increasing demand…
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Image creditFig 2. ACE2 mutants bind viral spike protein. by Ren et al., CC BY 4.0PLOS Pathogens Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry
Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes…
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PLOS ONE Whole-genome sequencing of SARS-CoV-2 reveals the detection of G614 variant in Pakistan
Since its emergence in China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide including Pakistan. During…
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PLOS ONE DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in mice
More than 65 million people have been confirmed infection with SARS-CoV-2 and more than 1 million have died from COVID-19 and this…
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Image creditFig 2. Haplotype analysis of SARS-CoV-2 viruses. by Anand et al., CC BY 4.0PLOS ONE A comprehensive SARS-CoV-2 genomic analysis identifies potential targets for drug repurposing
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is a novel human coronavirus strain (HCoV) was initially reported…
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PLOS Biology Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes
There are currently limited Food and Drug Administration (FDA)-approved drugs and vaccines for the treatment or prevention of Coronavirus…
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PLOS Computational Biology Gene variants of coagulation related proteins that interact with SARS-CoV-2
Thrombosis is a recognized complication of Coronavirus disease of 2019 (COVID-19) illness and is often associated with poor prognosis.…
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PLOS ONE Immuno-informatics design of a multimeric epitope peptide based vaccine targeting SARS-CoV-2 spike glycoprotein
Developing an efficacious vaccine for SARS-CoV-2 infection is critical to stemming COVID-19 fatalities and providing the global community…
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PLOS Pathogens A novel cell culture system modeling the SARS-CoV-2 life cycle
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the global pandemic of COVID-19. SARS-CoV-2 is classified as a…
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Image creditFig 1. SARS-CoV-2 lentiviral pseudovirus infectivity under various conditions. by Neerukonda et al., CC BY 4.0PLOS ONE Establishment of a well-characterized SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells with stable expression of ACE2 and TMPRSS2
Pseudoviruses are useful surrogates for highly pathogenic viruses because of their safety, genetic stability, and scalability for…
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PLOS Computational Biology A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19
Abnormal coagulation and an increased risk of thrombosis are features of severe COVID-19, with parallels proposed with hemophagocytic…
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Image creditFig 4. Serum antibody titers in sera from 2017. by Yokoyama et al., CC BY 4.0PLOS ONE Validation of a new automated chemiluminescent anti-SARS-CoV-2 IgM and IgG antibody assay system detecting both N and S proteins in Japan
PCR methods are presently the standard for the diagnosis of Coronavirus disease 2019 (COVID-19), but additional methodologies are needed…
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PLOS ONE Genomic characterization and evolution of SARS-CoV-2 of a Canadian population
COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of…
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PLOS Neglected Tropical Diseases Nucleic acid visualization assay for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) by targeting the UpE and N gene
Since its first emergence in 2012, cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) have continued to…
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PLOS ONE Extraction-free protocol combining proteinase K and heat inactivation for detection of SARS-CoV-2 by RT-qPCR
Real-time reverse transcription PCR (RT-qPCR) is the gold-standard technique for severe acute respiratory syndrome coronavirus 2…
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PLOS Biology A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research
The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the underlying cause of Coronavirus Disease 2019…
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Image creditFig 3. Genotyping calls for all samples. by Harper et al., CC BY 4.0PLOS ONE Detecting SARS-CoV-2 variants with SNP genotyping
Tracking genetic variations from positive SARS-CoV-2 samples yields crucial information about the number of variants circulating in an…
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PLOS ONE Phenol-chloroform-based RNA purification for detection of SARS-CoV-2 by RT-qPCR: Comparison with automated systems
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly reached pandemic levels. Sufficient testing for…
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PLOS ONE SARS-CoV-2 genetic diversity in Venezuela: Predominance of D614G variants and analysis of one outbreak
SARS-CoV-2 is the new coronavirus responsible for COVID-19 disease. The first two cases of COVID-19 were detected in Venezuela on March…
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PLOS ONE Exploring novel and potent cell penetrating peptides in the proteome of SARS-COV-2 using bioinformatics approaches
Among various delivery systems for vaccine and drug delivery, cell-penetrating peptides (CPPs) have been known as a potent delivery system…
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Image creditNovel Coronavirus SARS-CoV-2 by NIAID-RML, CC BY 4.0PLOS Biology COVID-19 induces a hyperactive phenotype in circulating platelets
Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has affected over…
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Image creditFig 4. Some motifs matched the epitopes on the spike protein. by Martínez et al., CC BY 4.0PLOS ONE The analysis on the human protein domain targets and host-like interacting motifs for the MERS-CoV and SARS-CoV/CoV-2 infers the molecular mimicry of coronavirus
The MERS-CoV, SARS-CoV, and SARS-CoV-2 are highly pathogenic viruses that can cause severe pneumonic diseases in humans. Unfortunately,…
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PLOS ONE In silico analysis suggests less effective MHC-II presentation of SARS-CoV-2 RBM peptides: Implication for neutralizing antibody responses
SARS-CoV-2 antibodies develop within two weeks of infection, but wane relatively rapidly post-infection, raising concerns about whether…
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PLOS ONE Rapid processing of SARS-CoV-2 containing specimens for direct RT-PCR
Widespread diagnostic testing is needed to reduce transmission of COVID-19 and manage the pandemic. Effective mass screening requires…
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PLOS Pathogens Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins
Receptor binding studies on sarbecoviruses would benefit from an available toolkit of recombinant spike proteins, or domains thereof, that…
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PLOS ONE Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan
Background: In this study, we performed molecular characterization of SARS-CoV-2 strains in Hiroshima and its mutation pattern between the…
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PLOS ONE Comparative performance of SARS-CoV-2 real-time PCR diagnostic assays on samples from Lagos, Nigeria
A key element in containing the spread of the SARS-CoV-2 infection is quality diagnostics which is affected by several factors. We now…
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Image creditFig 1. ViralLink workflow overview. by Treveil et al., CC BY 4.0PLOS Computational Biology ViralLink: An integrated workflow to investigate the effect of SARS-CoV-2 on intracellular signalling and regulatory pathways
The SARS-CoV-2 pandemic of 2020 has mobilised scientists around the globe to research all aspects of the coronavirus virus and its…
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PLOS ONE Uncovering potential host proteins and pathways that may interact with eukaryotic short linear motifs in viral proteins of MERS, SARS and SARS2 coronaviruses that infect humans
A coronavirus pandemic caused by a novel coronavirus (SARS-CoV-2) has spread rapidly worldwide since December 2019. Improved understanding…
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Image creditFig 8. Summary of testing options. by Graham et al., CC BY 4.0PLOS ONE Open-source RNA extraction and RT-qPCR methods for SARS-CoV-2 detection
Re-opening of communities in the midst of the ongoing COVID-19 pandemic has ignited new waves of infections in many places around the…
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Image creditFig 1. Chest computed tomographic, and X-ray images. by Muttineni et al., CC BY 4.0PLOS ONE Clinical and whole genome characterization of SARS-CoV-2 in India
We report clinical profile of hundred and nine patients with SARS CoV-2 infection, and whole genome sequences (WGS) of seven virus…
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PLOS ONE High-level expression of the monomeric SARS-CoV-2 S protein RBD 320-537 in stably transfected CHO cells by the EEF1A1-based plasmid vector
The spike (S) protein is one of the three proteins forming the coronaviruses’ viral envelope. The S protein of the Severe Acute…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0PLOS ONE Development and performance evaluation of a rapid in-house ELISA for retrospective serosurveillance of SARS-CoV-2
Background: In the ongoing pandemic situation of COVID-19, serological tests can complement the molecular diagnostic methods, and can be…
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PLOS Pathogens Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice
The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete…
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PLOS ONE Switched and unswitched memory B cells detected during SARS-CoV-2 convalescence correlate with limited symptom duration
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the pandemic human respiratory illness COVID-19, is a…
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PLOS Pathogens Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium
The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to…
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PLOS ONE Generalized linear models provide a measure of virulence for specific mutations in SARS-CoV-2 strains
This study aims to highlight SARS-COV-2 mutations which are associated with increased or decreased viral virulence. We utilize genetic…
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PLOS ONE T cell response to SARS-CoV-2 infection in humans: A systematic review
Background: Understanding the T cell response to SARS-CoV-2 is critical to vaccine development, epidemiological surveillance and disease…
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PLOS ONE Screening, simulation, and optimization design of small molecule inhibitors of the SARS-CoV-2 spike glycoprotein
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is a public health emergency of international concern. The spike…
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PLOS Pathogens Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to the host cell receptor ACE2 and undergoing…
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PLOS ONE Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice
SARS-CoV-2 is a single stranded RNA (ssRNA) virus and contains GU-rich sequences distributed abundantly in the genome. In COVID-19, the…
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PLOS Pathogens SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells
The spike (S) protein of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) binds to a host cell receptor which facilitates…
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PLOS ONE In silico comparative genomics of SARS-CoV-2 to determine the source and diversity of the pathogen in Bangladesh
The COVID19 pandemic caused by SARS-CoV-2 virus has severely affected most countries of the world including Bangladesh. We conducted…
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PLOS Pathogens Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2
Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits viral infection of SARS coronavirus…
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PLOS Pathogens The coronavirus proofreading exoribonuclease mediates extensive viral recombination
Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of SARS-CoV-2 and other zoonotic CoVs. While RNA…
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PLOS ONE Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study
Kidneys are one of the targets for SARS-CoV-2, it is reported that up to 36% of patients with SARS-CoV-2 infection would develop into…
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PLOS ONE Full length genomic sanger sequencing and phylogenetic analysis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Nigeria
In an outbreak, effective detection of the aetiological agent(s) involved using molecular techniques is key to efficient diagnosis, early…
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PLOS ONE Performing point-of-care molecular testing for SARS-CoV-2 with RNA extraction and isothermal amplification
To respond to the urgent need for COVID-19 testing, countries perform nucleic acid amplification tests (NAAT) for the detection of…
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PLOS ONE Development of a reverse transcription recombinase polymerase amplification assay for rapid and direct visual detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Rapid diagnosis is an important intervention in managing the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak. Real…
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PLOS Computational Biology A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus poses serious threats to the global public health and…
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PLOS ONE A direct RT-qPCR approach to test large numbers of individuals for SARS-CoV-2
SARS-CoV-2 causes substantial morbidity and mortality in elderly and immunocompromised individuals, particularly in retirement homes,…
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PLOS ONE Informed sequential pooling approach to detect SARS-CoV-2 infection
The alarming spread of the pandemic coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus requires several measures to reduce…
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PLOS ONE ACE2 polymorphisms as potential players in COVID-19 outcome
The clinical condition COVID-19, caused by SARS-CoV-2, was declared a pandemic by the WHO in March 2020. Currently, there are more than 5…
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PLOS ONE Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory coronavirus 2 (SARS-COV-2) is a significant threat to…
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PLOS Biology The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins
SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause…
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PLOS Genetics Recombination events are concentrated in the spike protein region of Betacoronaviruses
The Betacoronaviruses comprise multiple subgenera whose members have been implicated in human disease. As with SARS, MERS and now…
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PLOS Pathogens mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2
The novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic. Critical to the rapid…
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PLOS Pathogens Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators
Viruses are obligate intracellular parasites that make use of the host metabolic machineries to meet their biosynthetic needs. Thus,…
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PLOS Biology Rapid detection of SARS-CoV-2 with CRISPR-Cas12a
The recent outbreak of betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which is responsible for the…
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PLOS Biology A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection
With the ongoing COVID-19 (Coronavirus Disease 2019) pandemic, caused by the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory…
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PLOS ONE Female reproductive tract has low concentration of SARS-CoV2 receptors
There has been significant concern regarding fertility and reproductive outcomes during the SARS-CoV2 pandemic. Recent data suggests a…
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PLOS Pathogens Disentangling the dynamical underpinnings of differences in SARS-CoV-2 pathology using within-host ecological models
Health outcomes following infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) are remarkably variable. The way the…
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PLOS ONE False-negative results of initial RT-PCR assays for COVID-19: A systematic review
Background: A false-negative case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is defined as a person with…
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PLOS ONE Retinoic acid improves baseline barrier function and attenuates TNF-α-induced barrier leak in human bronchial epithelial cell culture model, 16HBE 14o-
Retinoic acid (RA) has been shown to improve epithelial and endothelial barrier function and development and even suppress damage…
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PLOS ONE CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and prevention
The ongoing pandemic of SARS-CoV-2 has brought tremendous crisis on global health care systems and industrial operations that dramatically…
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PLOS ONE The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1
The SARS-CoV-2 (COVID-19) pandemic is a global crisis that threatens our way of life. As of November 18, 2020, SARS-CoV-2 has claimed more…
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PLOS Computational Biology Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection
The entry of SARS-CoV-2 into target cells requires the activation of its surface spike protein, S, by host proteases. The host serine…
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PLOS Computational Biology In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species
The coronavirus disease COVID-19 constitutes the most severe pandemic of the last decades having caused more than 1 million deaths…
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PLOS ONE Molecular detection of SARS-CoV-2 using a reagent-free approach
Shortage of reagents and consumables required for the extraction and molecular detection of SARS-CoV-2 RNA in respiratory samples has led…
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PLOS ONE Alignment of virus-host protein-protein interaction networks by integer linear programming: SARS-CoV-2
Motivation: Beside socio-economic issues, coronavirus pandemic COVID-19, the infectious disease caused by the newly discovered coronavirus…
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PLOS Pathogens Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles
The novel coronavirus SARS-CoV-2 is the causative agent of Coronavirus Disease 2019 (COVID-19), a global healthcare and economic…
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PLOS Pathogens SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells
Cytokine storm is suggested as one of the major pathological characteristics of SARS-CoV-2 infection, although the mechanism for…
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PLOS Pathogens A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody
Epitopes that are conserved among SARS-like coronaviruses are attractive targets for design of cross-reactive vaccines and therapeutics.…
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PLOS Computational Biology Insights on cross-species transmission of SARS-CoV-2 from structural modeling
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global pandemic that has infected more than 31…
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PLOS Pathogens Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19). SARS-CoV-2…
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PLOS ONE Seroprevalence analysis of SARS-CoV-2 in pregnant women along the first pandemic outbreak and perinatal outcome
Objectives: To evaluate the progression of the seroprevalence of SARS-CoV-2 in the pregnant population of the south of Madrid during the…
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PLOS Genetics Stability of SARS-CoV-2 phylogenies
The SARS-CoV-2 pandemic has led to unprecedented, nearly real-time genetic tracing due to the rapid community sequencing response.…
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PLOS ONE Sensitivity evaluation of 2019 novel coronavirus (SARS-CoV-2) RT-PCR detection kits and strategy to reduce false negative
The early detection and differential diagnosis of respiratory infections increase the chances for successful control of COVID-19 disease.…
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PLOS ONE Genetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam
A second cluster of COVID-19 cases imported from Europe occured in Vietnam from early March 2020. We describe 44 SARS-CoV-2 RT-PCR…
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PLOS ONE Association of SARS-CoV-2 genomic load trends with clinical status in COVID-19: A retrospective analysis from an academic hospital center in New York City
The Infectious Diseases Society of America has identified the use of SARS-CoV-2 genomic load for prognostication purposes as a key…
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PLOS ONE Seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar, northern India – A cross-sectional study
Background: Prevalence of IgG antibodies against SARS-CoV-2 infection provides essential information for deciding disease prevention and…
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PLOS ONE Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations
In late December 2019, an emerging viral infection COVID-19 was identified in Wuhan, China, and became a global pandemic. Characterization…
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PLOS ONE Static all-atom energetic mappings of the SARS-Cov-2 spike protein and dynamic stability analysis of “Up” versus “Down” protomer states
The SARS-CoV-2 virion responsible for the current world-wide pandemic COVID-19 has a characteristic Spike protein (S) on its surface that…
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PLOS ONE A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19
Coronavirus Disease 2019 (COVID-19) has recently become a public emergency and a worldwide pandemic. However, the information on the risk…
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PLOS ONE Recommendations for sample pooling on the Cepheid GeneXpert® system using the Cepheid Xpert® Xpress SARS-CoV-2 assay
The coronavirus disease 2019 (Covid-19) pandemic, caused by SARS-CoV-2, has resulted in a global testing supply shortage. In response,…
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PLOS ONE Variant analysis of 1,040 SARS-CoV-2 genomes
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As…
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PLOS Pathogens The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors
Over the last 2 decades, several coronaviruses (CoVs) have crossed the species barrier into humans, causing highly prevalent and severe…
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PLOS ONE Detection of SARS-CoV-2 from raw patient samples by coupled high temperature reverse transcription and amplification
SARS-CoV-2 is spreading globally with unprecedented consequences for modern societies. The early detection of infected individuals is a…
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PLOS ONE SARS-CoV-2 transmission routes from genetic data: A Danish case study
Background: The first cases of COVID-19 caused by the SARS-CoV-2 virus were reported in China in December 2019. The disease has since…
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PLOS ONE Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2
The World Health Organization declared the COVID-19 epidemic a public health emergency of international concern on March 11th, 2020, and…
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PLOS Neglected Tropical Diseases Air and surface contamination in non-health care settings among 641 environmental specimens of 39 COVID-19 cases
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PLOS Biology Detection of SARS-CoV-2 RNA by multiplex RT-qPCR
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PLOS Computational Biology IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis
Hardware
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Image credit3D print of a SARS-CoV-2 by Rawpixel Ltd, CC BY 2.0PLOS ONE Evaluation of the efficacy of LAMP-based SARS-CoV-2 detection with simple RNA extraction from nasopharyngeal swabs: A prospective observational study
The Loopamp SARS-CoV-2 Detection Kit is used for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).…
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Image creditCoronavirus by sergio santos, CC BY 2.0PLOS ONE Analysis of the initial lot of the CDC 2019-Novel Coronavirus (2019-nCoV) real-time RT-PCR diagnostic panel
At the start of the COVID-19 pandemic, the Centers for Disease Control and Prevention (CDC) designed, manufactured, and distributed the…
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Image creditProtective medical mask on globe closeup by Nenad Stojkovic, CC BY 2.0PLOS ONE The role of conformity in mask-wearing during COVID-19
By September 2020, COVID-19 had claimed the lives of almost 1 million people worldwide, including more than 400,000 in the U.S. and Europe…
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PLOS ONE A systematic review and meta-analysis of indoor bioaerosols in hospitals: The influence of heating, ventilation, and air conditioning
Objectives: To evaluate (1) the relationship between heating, ventilation, and air conditioning (HVAC) systems and bioaerosol…
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PLOS ONE The evaluation of the utility of the GENECUBE HQ SARS-CoV-2 for anterior nasal samples and saliva samples with a new rapid examination protocol
Introduction: GENECUBE® is a rapid molecular identification system, and previous studies demonstrated that GENECUBE® HQ SARS-CoV-2 showed…
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PLOS ONE Dry heat sterilization as a method to recycle N95 respirator masks: The importance of fit
In times of crisis, including the current COVID-19 pandemic, the supply chain of filtering facepiece respirators, such as N95 respirators,…
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PLOS ONE Exhaled nitric oxide detection for diagnosis of COVID-19 in critically ill patients
Background: COVID-19 may present with a variety of clinical syndromes, however, the upper airway and the lower respiratory tract are the…
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10.1371/journal.pone.0257549 CC BY 4.0" title="10.1371/journal.pone.0257549 CC BY 4.0">Image creditPLOS ONE Laminar flow ventilation system to prevent airborne infection during exercise in the COVID-19 crisis: A single-center observational study
Particulate generation occurs during exercise-induced exhalation, and research on this topic is scarce. Moreover, infection-control…
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PLOS ONE A SARS-CoV-2 coronavirus nucleocapsid protein antigen-detecting lateral flow assay
Inexpensive, simple, rapid diagnostics are necessary for efficient detection, treatment, and mitigation of COVID-19. Assays for SARS-CoV2…
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PLOS ONE LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples
Clinical and surveillance testing for the SARS-CoV-2 virus relies overwhelmingly on RT-qPCR-based diagnostics, yet several popular assays…
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PLOS ONE Evaluation of a bioaerosol sampler for indoor environmental surveillance of Severe Acute Respiratory Syndrome Coronavirus 2
The worldwide spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has ubiquitously impacted many aspects of life. As…
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PLOS ONE Sampling site for SARS-CoV-2 RT-PCR—An intrapatient four-site comparison from Tampere, Finland
Background: SARS-CoV-2 diagnosis relies on the performance of nasopharyngeal swabs. Alternative sample sites have been assessed but the…
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PLOS ONE Validation of a novel molecular assay to the diagnostic of COVID-19 based on real time PCR with high resolution melting
The emergence of the COVID-19 pandemic resulted in an unprecedented need for RT-qPCR-based molecular diagnostic testing, placing a strain…
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PLOS ONE Evaluation of electrostatic sprayers and foggers for the application of disinfectants in the era of SARS-CoV-2
Although research has shown that the COVID-19 disease is most likely caused by airborne transmission of the SARS-CoV-2 virus, disinfection…
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PLOS ONE An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses
Numerous assays evaluating serological and cellular responses have been developed to characterize immune responses against SARS-CoV-2.…
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PLOS ONE The protective performance of reusable cloth face masks, disposable procedure masks, KN95 masks and N95 respirators: Filtration and total inward leakage
Face coverings are a key component of preventive health measure strategies to mitigate the spread of respiratory illnesses. In this study…
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PLOS ONE Evaluation of the clinical performance of a magnetic force-assisted electrochemical immunoassay for the detection of SARS-CoV-2 antigens
Rapid antigen (Ag) tests for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provide quick results, do not…
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PLOS ONE The effect of increasing indoor ventilation on artificially generated aerosol particle counts
The COVID-19 global pandemic has caused millions of infections and deaths despite mitigation efforts that involve physical distancing,…
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PLOS ONE Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus
Decontaminating N95 respirators for reuse could mitigate shortages during the COVID-19 pandemic. Although the United States Center for…
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PLOS ONE Assessing a chip based rapid RTPCR test for SARS CoV-2 detection (TrueNat assay): A diagnostic accuracy study
COVID-19 testing is required before admission of a patient in the hospitals, invasive procedures, major and minor surgeries etc. Real Time…
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PLOS ONE Impact of ultraviolet germicidal irradiation on new silicone half-piece elastometric respirator (VJR-NMU) performance, structural integrity and sterility during the COVID-19 pandemic
Since the innovation of our new half-piece elastometric respirator, this type of filtering facepiece respirator (FFR) has been used widely…
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PLOS Computational Biology Factors affecting aerosol SARS-CoV-2 transmission via HVAC systems; a modeling study
The role of heating, ventilation, and air-conditioning (HVAC) systems in the transmission of SARS-CoV-2 is unclear. To address this gap,…
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Image creditFig 1. In-ear monitoring device and measurements by Wurzer et al., CC BY 4.0PLOS ONE Remote monitoring of COVID-19 positive high-risk patients in domestic isolation: A feasibility study
Background: If a COVID-19 patient develops a so-called severe course, he or she must be taken to hospital as soon as possible. This proves…
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Image creditFig 4. SARS-CoV-2 live virus CDC EUA N1 RT-qPCR assay by Jones et al., CC BY 4.0PLOS ONE Isothermal amplification and fluorescent detection of SARS-CoV-2 and SARS-CoV-2 variant virus in nasopharyngeal swabs
The COVID-19 pandemic caused by the SARS-CoV-2 is a serious health threat causing worldwide morbidity and mortality. Real-time reverse…
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Image creditFig 6. Sensitivity and specificity of WHotLAMP by Ng etal., CC BY 4.0PLOS ONE WHotLAMP: A simple, inexpensive, and sensitive molecular test for the detection of SARS-CoV-2 in saliva
Despite the development of effective vaccines against SARS-CoV-2, epidemiological control of the virus is still challenging due to slow…
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Image creditFig 1. Autoclave procedure with Halyard laminate bags by van Straten et al., CC BY 4.0PLOS ONE Can sterilization of disposable face masks be an alternative for imported face masks? A nationwide field study including 19 sterilization departments and 471 imported brand types during COVID-19 shortages
Background: Face masks, also referred to as half masks, are essential to protect healthcare professionals working in close contact with…
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PLOS ONE Diagnostic accuracy and acceptability of molecular diagnosis of COVID-19 on saliva samples relative to nasopharyngeal swabs in tropical hospital and extra-hospital contexts: The COVISAL study
A prospective study was conducted among different intra and extra-hospital populations of French Guiana to evaluate the performance of…
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PLOS ONE A high-throughput microsphere-based immunoassay of anti-SARS-CoV-2 IgM testing for COVID-19 diagnostics
The pandemic of novel coronavirus disease COVID-19 is rapidly expanding across the world. A positive result of antibody tests suggests…
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PLOS ONE Self-collection of capillary blood using Tasso-SST devices for Anti-SARS-CoV-2 IgG antibody testing
Background: Efforts to minimize COVID-19 exposure during the current SARS-CoV-2 pandemic have led to limitations in access to medical care…
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PLOS ONE Can follow up lung ultrasound in Coronavirus Disease-19 patients indicate clinical outcome?
Purpose: To evaluate whether there is a change in findings of coronavirus disease 2019 patients in follow up lung ultrasound and to…
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Image creditTest tubes on blue by Jernej Furman, CC BY 2.0PLOS ONE Development of an alternative saliva test for diagnosis of SARS-CoV-2 using TRIzol: Adapting to countries with lower incomes looking for a large-scale detection program
The use of saliva for the diagnosis of SARS-CoV-2 has shown to be a good alternative to nasopharyngeal swabs (NPS), since it permits…
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PLOS ONE Clinical validation of an open-access SARS-COV-2 antigen detection lateral flow assay, compared to commercially available assays
Rapid tests for SARS-COV-2 infection are important tools for pandemic control, but current rapid tests are based on proprietary designs…
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PLOS ONE Study of the use of a personalized peripheral sealing device on surgical face masks in high-risk situations against COVID-19
A significant number of health care professionals subjected to high-risk situations have been infected by Covid-19 due to the lack of…
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PLOS ONE Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples
Saliva is an attractive specimen type for asymptomatic surveillance of COVID-19 in large populations due to its ease of collection and its…
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Image creditFig 5. Product structure by Yu et al., CC BY 4.0PLOS ONE Determining the critical factors of air-conditioning innovation using an integrated model of fuzzy Kano-QFD during the COVID-19 pandemic: The perspective of air purification
At present, people are demanding better indoor air quality during the COVID-19 pandemic. In addition to maintaining the basic functions,…
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PLOS ONE UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic
Personal protective equipment (PPE) is crucially important to the safety of both patients and medical personnel, particularly in the event…
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PLOS ONE Construction and validation of an ultraviolet germicidal irradiation system using locally available components
Coronavirus disease (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, is…
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Image creditFig 1. Diagram of the OT2-KF circuit by Villanueva-Cañas et al., CC BY 4.0PLOS ONE Implementation of an open-source robotic platform for SARS-CoV-2 testing by real-time RT-PCR
The current global pandemic due to the SARS-CoV-2 has pushed the limits of global health systems across all aspects of clinical care,…
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Image creditFig 1. Limit of detection (LOD). by Frank et al., CC BY 4.0PLOS ONE DRUL for school: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2
To address the need for simple, safe, sensitive, and scalable SARS-CoV-2 tests, we validated and implemented a PCR test that uses a saliva…
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PLOS ONE Diagnostic accuracy of Panbio rapid antigen tests on oropharyngeal swabs for detection of SARS-CoV-2
Background: Antigen-detecting rapid diagnostic tests (Ag-RDTs) for the detection of SARS-CoV-2 offer new opportunities for testing in the…
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PLOS ONE One size fits all?: A simulation framework for face-mask fit on population-based faces
The use of face masks by the general population during viral outbreaks such as the COVID-19 pandemic, although at times controversial, has…
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Image creditFig 7. Funnel plot of standard error. by Elsayed et al., CC BY 4.0PLOS ONE Variation in outcome of invasive mechanical ventilation between different countries for patients with severe COVID-19: A systematic review and meta-analysis
Background: COVID 19 is the most recent cause of Adult respiratory distress syndrome ARDS. Invasive mechanical ventilation IMV can support…
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PLOS ONE Potential application of novel technology developed for instant decontamination of personal protective equipment before the doffing step
The use of personal protective equipment (PPE) has been considered the most effective way to avoid the contamination of healthcare workers…
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Image creditFig 2. Issues identified through taint analysis. by Kouliaridis et al., CC BY 4.0PLOS ONE Dissecting contact tracing apps in the Android platform
Contact tracing has historically been used to retard the spread of infectious diseases, but if it is exercised by hand in large-scale, it…
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PLOS ONE Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining
We study the effects of two mechanisms which increase the efficacy of contact-tracing applications (CTAs) such as the mobile phone…
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Image creditFig 3. Illustration of the regions where WSPs were applied. by Freitas Neves et al., CC BY 4.0PLOS ONE Numerical and experimental analyses for the improvement of surface instant decontamination technology through biocidal agent dispersion: Potential of application during pandemic
The transmission of SARS-CoV-2 through contact with contaminated surfaces or objects is an important form of transmissibility. Thus, in…
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PLOS ONE Trustworthiness appraisals of faces wearing a surgical mask during the Covid-19 pandemic in Germany: An experimental study
Background: During the Covid-19 pandemic, the negative effects of wearing a mouth-nose cover (MNC) on interpersonal functioning have been…
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PLOS ONE Mouth-nose masks impair the visual field of healthy eyes
Background: Mouth-nose masks have been requested to prevent the transmission of severe acute respiratory syndrome coronavirus-2…
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PLOS ONE Motivations, barriers, and communication recommendations for promoting face coverings during the COVID-19 pandemic: Survey findings from a diverse sample
State and local health departments have been tasked with promoting the use of face coverings to decrease the spread of COVID-19 in their…
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Image creditPPE Modeling by Christine Warner, CC BY 2.0PLOS ONE Online survey on healthcare skin reactions for wearing medical-grade protective equipment against COVID-19 in Hubei Province, China
With the spread of Coronavirus Disease 2019 globally, more than 40,000 healthcare staff rushed to Wuhan, Hubei Province to fight against…
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Image creditNovel Coronavirus SARS-CoV-2 by National Institute of Allergy and Infectious Diseases, NIH, CC-0 Public DomainPLOS ONE Perspectives of compounding pharmacists on alcohol-based hand sanitizer production and utilization for COVID-19 prevention in Addis Ababa, Ethiopia: A descriptive phenomenology study
Background: Globally, the safety of patients and healthcare providers is at risk due to health care-associated infections (HCAIs). World…
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Image creditFig 2. Data quality charts based on CASP checklist. by Hammond et al., CC BY 4.0PLOS ONE Should homes and workplaces purchase portable air filters to reduce the transmission of SARS-CoV-2 and other respiratory infections? A systematic review
Respiratory infections, including SARS-CoV-2, are spread via inhalation or ingestion of airborne pathogens. Airborne transmission is…
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Image creditFig 2. Tested devices. by Ball et al., CC BY 4.0PLOS ONE Effects of distancing and pattern of breathing on the filtering capability of commercial and custom-made facial masks: An in-vitro study
Background: Since the beginning of the COVID-19 pandemics, masking policies have been advocated. While masks are known to prevent…
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Image creditFig 1. Absorption and recovery of specimens from dry polyester swabs. by Padgett et al., CC BY 4.0PLOS ONE Polyester nasal swabs collected in a dry tube are a robust and inexpensive, minimal self-collection kit for SARS-CoV-2 testing
Background: In order to identify an inexpensive yet highly stable SARS-CoV-2 collection device as an alternative to foam swabs stored in…
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Image creditFig 1. Model 1-N95 cup-shaped respirator. by DeAngelis et al., CC BY 4.0PLOS ONE Gamma radiation sterilization of N95 respirators leads to decreased respirator performance
In response to personal protective equipment (PPE) shortages in the United States due to the Coronavirus Disease 2019, two models of N95…
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PLOS ONE Reusable snorkel masks adapted as particulate respirators
Introduction: During viral pandemics, filtering facepiece (FFP) masks together with eye protection form the essential components of…
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Image creditFig 1. Schematic representation of the model. by Lyng et al., CC BY 4.0PLOS ONE Identifying optimal COVID-19 testing strategies for schools and businesses: Balancing testing frequency, individual test technology, and cost
Background: COVID-19 test sensitivity and specificity have been widely examined and discussed, yet optimal use of these tests will depend…
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PLOS ONE Use of face masks to limit the spread of the COVID-19 among western Ugandans: Knowledge, attitude and practices
Background: The world is grappling with an ever-changing COVID-19 pandemic using preventive measures such as personal hygiene, face masks,…
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PLOS ONE Development, manufacturing, and preliminary validation of a reusable half-face respirator during the COVID-19 pandemic
Introduction: The COVID-19 pandemic has led to widespread shortages of N95 respirators and other personal protective equipment (PPE). An…
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PLOS ONE Facemask wearing to prevent COVID-19 transmission and associated factors among taxi drivers in Dessie City and Kombolcha Town, Ethiopia
Background: The World Health Organization (WHO) has pointed out that urban taxi drivers and their passengers are at higher risk of…
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PLOS ONE Medical face masks offer self-protection against aerosols: An evaluation using a practical in vitro approach on a dummy head
Since the appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the question regarding the efficacy of various…
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PLOS ONE The effects of wearing facemasks on oxygenation and ventilation at rest and during physical activity
Background: Facemasks are recommended to reduce the spread of SARS-CoV-2, but concern about inadequate gas exchange is an often cited…
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PLOS ONE A novel dental biosafety device to control the spread of potentially contaminated dispersion particles from dental ultrasonic tips
Strategies to return to dental practice in pandemic times is a new challenge due to the generation and spread of potentially contaminated…
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Image creditFig 1. Curved crease origami face shield design by Bukauskas et al., CC BY 4.0PLOS ONE Curved-crease origami face shields for infection control
The COVID-19 pandemic has created enormous global demand for personal protective equipment (PPE). Face shields are an important component…
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PLOS ONE Game theory to enhance stock management of Personal Protective Equipment (PPE) during the COVID-19 outbreak
Since the outbreak of the COVID-19 pandemic, many healthcare facilities have suffered from shortages in medical resources, particularly in…
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PLOS ONE Comparing the fit of N95, KN95, surgical, and cloth face masks and assessing the accuracy of fit checking
Introduction: The COVID-19 pandemic has made well-fitting face masks a critical piece of protective equipment for healthcare workers and…
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PLOS ONE Simultaneous ventilation in the Covid-19 pandemic. A bench study
COVID-19 pandemic sets the healthcare system to a shortage of ventilators. We aimed at assessing tidal volume (VT) delivery and air…
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PLOS ONE Modified full-face snorkel masks as reusable personal protective equipment for hospital personnel
Here we adapt and evaluate a full-face snorkel mask for use as personal protective equipment (PPE) for health care workers, who lack…
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PLOS ONE Comprehensive characterization of protective face coverings made from household fabrics
Background: Face coverings constitute an important strategy for containing pandemics, such as COVID-19. Infection from airborne respiratory…
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PLOS ONE Automatic clustering method to segment COVID-19 CT images
Coronavirus pandemic (COVID-19) has infected more than ten million persons worldwide. Therefore, researchers are trying to address various…
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PLOS ONE The new silicone elastometric half-piece respirator, VJR-NMU: A novel and effective tool to prevent COVID-19
Filter facepiece respirators (FFRs) are critical for preventing the transmission of respiratory tract infection disease, especially the…
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PLOS ONE Optimizing direct RT-LAMP to detect transmissible SARS-CoV-2 from primary nasopharyngeal swab samples
SARS-CoV-2 testing is crucial to controlling the spread of this virus, yet shortages of nucleic acid extraction supplies and other key…
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PLOS ONE Emergency ventilator for COVID-19
The COVID-19 pandemic disrupted the world in 2020 by spreading at unprecedented rates and causing tens of thousands of fatalities within a…
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PLOS ONE Decontamination of N95 masks for re-use employing 7 widely available sterilization methods
The response to the COVID-19 epidemic is generating severe shortages of personal protective equipment around the world. In particular, the…
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PLOS ONE Check the gap: Facemask performance and exhaled aerosol distributions around the wearer
Current facemask research focuses on material characterization and efficiency; however, facemasks are often not tested such that aerosol…
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PLOS ONE The accuracy of healthcare worker versus self collected (2-in-1) Oropharyngeal and Bilateral Mid-Turbinate (OPMT) swabs and saliva samples for SARS-CoV-2
Background: Self-sampling for SARS-CoV-2 would significantly raise testing capacity and reduce healthcare worker (HCW) exposure to…
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PLOS ONE Comparative effectiveness of N95 respirators and surgical/face masks in preventing airborne infections in the era of SARS-CoV2 pandemic: A meta-analysis of randomized trials
Background: Recently, several randomized controlled trials (RCTs) have evaluated the effect of N95 respirators compared with medical masks…
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PLOS ONE Optimised genetic algorithm-extreme learning machine approach for automatic COVID-19 detection
The coronavirus disease (COVID-19), is an ongoing global pandemic caused by severe acute respiratory syndrome. Chest Computed Tomography…
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PLOS ONE COVID-19 and human-nature relationships: Vermonters’ activities in nature and associated nonmaterial values during the pandemic
The COVID-19 pandemic has rapidly modified Earth’s social-ecological systems in many ways; here we study its impacts on human-nature…
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PLOS ONE Delivery system can vary ventilatory parameters across multiple patients from a single source of mechanical ventilation
Background: Current limitations in the supply of ventilators during the Covid19 pandemic have limited respiratory support for patients with…
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PLOS ONE Computational simulation to assess patient safety of uncompensated COVID-19 two-patient ventilator sharing using the Pulse Physiology Engine
Background: The COVID-19 pandemic is stretching medical resources internationally, sometimes creating ventilator shortages that complicate…
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PLOS ONE Exploring options for reprocessing of N95 Filtering Facepiece Respirators (N95-FFRs) amidst COVID-19 pandemic: A systematic review
Background: There is global shortage of Personal Protective Equipment due to COVID-19 pandemic. N95 Filtering Facepiece Respirators…
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PLOS ONE Maternal perception of masking in children as a preventive strategy for COVID-19 in Nigeria: A multicentre study
Background: The use of face masks by children for the prevention of COVID 19 is still controversial, especially with regards to who should…
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PLOS ONE A simple method to estimate flow restriction for dual ventilation of dissimilar patients: The BathRC model
Background: With large numbers of COVID-19 patients requiring mechanical ventilation and ventilators possibly being in short supply, in…
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PLOS ONE Subject validation of reusable N95 stop-gap filtering facepiece respirators in COVID-19 pandemic
Introduction: The COVID-19 pandemic has unveiled widespread shortages of personal protective equipment including N95 respirators. Several…
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PLOS ONE Availability of personal protective equipment and diagnostic and treatment facilities for healthcare workers involved in COVID-19 care: A cross-sectional study in Brazil, Colombia, and Ecuador
Many affected counties have had experienced a shortage of personal protective equipment (PPE) during the coronavirus disease (COVID-19)…
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PLOS Neglected Tropical Diseases Development and evaluation of a rapid and simple diagnostic assay for COVID-19 based on loop-mediated isothermal amplification
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic novel coronavirus that has caused a worldwide…
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PLOS ONE Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay
Background: Rapid and extensive testing of large parts of the population and specific subgroups is crucial for proper management of severe…
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PLOS ONE Sample adequacy controls for infectious disease diagnosis by oral swabbing
Oral swabs are emerging as a non-invasive sample type for diagnosing infectious diseases including Ebola, tuberculosis (TB), and COVID-19.…
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PLOS ONE A comparison of health care worker-collected foam and polyester nasal swabs in convalescent COVID-19 patients
Both polyester and foam nasal swabs were collected from convalescent COVID-19 patients at a single visit and stored in viral transport…
PLOS Collections
We examined the changes in cognitive function due to restrictions in daily life during the coronavirus disease 2019 (COVID-19) pandemic in…
Objective: COVID-19 has affected people’s health in various ways. University students are a particularly sensitive group for mental and…
Introduction: Worldwide, children with disabilities are a vulnerable population and at high risk for COVID-19 morbidity and mortality.…
Medical personnel working in emergency rooms (ER) are at increased risk of mental health problems and suicidality. There is increasing…
Introduction: While there has been considerable analysis of the health and economic effects of COVID-19 in the Global North, representative…
Background: Historically social connection has been an important way through which humans have coped with large-scale threatening events.…
COVID-19 has ruptured routines and caused breakdowns in what had been conventional practice and custom: everything from going to work and…
COVID-19 infection and the resultant restrictions has impacted all aspects of life across the world. This study explores factors that…
Introduction: COVID-19 poses significant health and economic threat prompting international firms to rapidly develop vaccines and secure…
Background: Determining the success of infectious disease outbreak prevention is dependent mainly on public knowledge and compliance…
Importance: COVID-19 vaccine hesitancy has become a leading barrier to increasing the US vaccination rate. Objective: To evaluate time…
There is widespread recognition that stressors related to Coronavirus Disease 2019 (COVID-19) jeopardize the development of emerging…
Background: Refugees are at increased risk for COVID-19 infection in part due to their living conditions, which make it harder to adopt and…
Introduction: Coronavirus disease 2019 (COVID-19) has led to radical changes in social distancing awareness and affected social…
Since the outbreak of Covid-19, the use of digital devices, especially smartphones, remarkably increased. Smartphone use belongs to one’s…
During the COVID-19 pandemic, US populations have experienced elevated rates of financial and psychological distress that could lead to…
Objective: Since the start of the COVID-19 pandemic, there have been concerns that social distancing may negatively impact mental health,…
Background: The rapid development of COVID-19 vaccines has brought an unprecedented focus on public attitudes to vaccines, with intention…
There has been resistance to COVID-19 public health restrictions partly due to changes and reductions in work, resulting in financial…
Universal screening for suicidal ideation in primary care and mental health settings has become a key prevention tool in many healthcare…
As a first line of defense to the COVID-19 pandemic in 2020, people reduced social contacts to avoid pathogen exposure. Using a panel of…
Vaccination willingness is a critical factor in pandemics, including the COVID-19 crisis. Therefore, investigating underlying drivers of…
Background: COVID-19 pandemic has had a global major healthcare, social and economic impact. In present study we aim to adapt the Fear of…
The COVID-19 pandemic and the measures to counteract it have highlighted the role of individual differences in evaluating and reacting to…
Background: COVID-19 has posed unique challenges for adolescents in different dimensions of their life including education, home and social…
Equal Access to the COVID-19 vaccine for all remains a major public health issue. The current study compared the prevalence of vaccination…
The deadliest coronavirus disease 2019 (COVID-19) is taking thousands of lives worldwide and presents an extraordinary challenge to mental…
Socioeconomic crisis and humanitarian disasters can cause increased stress for women who experience inter-partner violence (IPV). This…
Objectives: This study aims to investigate the potential factors associated with mental health outcomes among Chinese adults during the…
The COVID-19 pandemic poses many real-world moral dilemmas, which can pit the needs and rights of the many against the needs and rights of…
Aim: The long-term stress, anxiety and job burnout experienced by healthcare workers (HCWs) are important to consider as the novel…
Background: The Ethiopian Federal government has locked down schools as one measure to contain Covid-19 pandemic. Psychological effect of…
Background: Community pharmacists play an important role in reducing COVID-19-related secondary health problems. However, the knowledge,…
The efficacy of the public health measures to mitigate COVID-19 is influenced by health literacy which includes the level of knowledge…
Some people feel they are invincible to the novel coronavirus SARS-CoV-2 (COVID-19). They believe that being infected with COVID-19 would…
Background: In April 2020, the United Nations predicted that the COVID-19 pandemic will have a ‘calamitous’ impact on the lives of women.…
Background: Novel viral pandemics present significant challenges to global public health. Non-pharmaceutical interventions (e.g. social…
As of May 2021, over 286 million coronavirus 2019 (COVID-19) vaccine doses have been administered across the country. This data is…
As safe and effective vaccines become widely available, attaining herd immunity and limiting the spread of COVID-19 will depend on…
Background: Worldwide, strict infection control measures including visitation regulations were implemented due to the COVID-19 pandemic at…
Background: Since the beginning of the COVID-19 outbreak, many pharmaceutical companies have been racing to develop a safe and effective…
Objective: To describe the work environment and COVID-19 mitigation measures for homeless shelter workers and assess occupational risk…
Background: In the United States, underserved communities including Blacks and Latinx are disproportionately affected by COVID-19. This…
Healthcare workers have had the longest and most direct exposure to COVID-19 and consequently may suffer from poor mental health. We…
Previous research has shown that the COVID-19 outbreak, social distancing, and lockdown can affect people’s psychological well-being. The…
When emerging technologies transform an organization’s way of working, explorative business process management (BPM) becomes a new…
Latin American governments swiftly implemented income assistance programs to sustain families’ livelihoods during COVID-19 stay-at-home…
Protective behaviors such as mask wearing and physical distancing are critical to slow the spread of COVID-19, even in the context of…
A lockdown implies a shift from the public to the private sphere, and from market to non-market production, thereby increasing the volume…
Background: Infectious disease outbreaks like COVID-19 and their mitigation measures can exacerbate underlying gender disparities,…
Having a vaccine available does not necessarily imply that it will be used. Indeed, uptake rates for existing vaccines against infectious…
Objective: Explore how previous work during the 2003 Severe Acute Respiratory Syndrome (SARS) outbreak affects the psychological response…
An understanding of the types of shocks that disrupt and negatively impact urban household food security is of critical importance to…
Racial/ethnic disparities are among the top-selective underlying determinants associated with the disproportional impact of the COVID-19…
The COVID-19 pandemic has affected all dimensions of lives and has become a social problem as it continues to spread widely through the…
Medical leaders have warned of the potential public health burden of a “parallel pandemic” faced by healthcare workers during the COVID-19…
The emergence of a pandemic is usually accompanied by different measures–economic, social, preventive, and (self)protective. In the case…
This study used a subsample of a household panel study in Italy to track changes in mental health before the onset of COVID-19 and into…
As the early COVID-19 outbreak sparked xenophobia against people of Asian and Chinese background, we collected data from Chinese migrants…
The Coronavirus Disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first appeared in Wuhan, China…
Background: Novel coronavirus disease 2019 (COVID-19) vaccine hesitancy is a barrier to achieving herd immunity, and thus, a prominent…
Here, we sought to quantify the effects of experienced fear and worry, engendered by the COVID-19 pandemic, on both cognitive…
State governments in the U.S. have been facing difficult decisions involving tradeoffs between economic and health-related outcomes during…
Background: Professional burnout represents a significant threat to the American healthcare system. Organizational and individual factors…
Background: During the Coronavirus Disease 2019 (COVID-19) pandemic, the number of consultations and diagnoses in primary care and…
Background: In response to the COVID-19 pandemic, governments have implemented a range of non-pharmaceutical interventions (NPIs) and…
This study explored relations between COVID-19 news source, trust in COVID-19 information source, and COVID-19 health literacy in 194…
Introduction: The COVID-19 pandemic has initiated an upheaval in society and has been the cause of considerable stress during this period.…
The turnover intention of healthcare workers is a threat to the competence of health services, especially during COVID-19 time. This study…
In the absence of widespread vaccination for COVID-19, governments and public health officials have advocated for the public to wear masks…
Background: Older adults, including those with long-term conditions (LTCs), are vulnerable to social isolation. They are likely to have…
Faces are one of the key ways that we obtain social information about others. They allow people to identify individuals, understand…
People often seek out information as a means of coping with challenging situations. Attuning to negative information can be adaptive…
The COVID-19 pandemic has necessitated physical distancing which is expected to continue in some form for the foreseeable future. Physical…
Coronavirus Disease-2019 (COVID-19) quickly surged the whole world and affected people’s physical, mental, and social health thereby…
Public perceptions of pandemic viral threats and government policies can influence adherence to containment, delay, and mitigation…
Background: The COVID-19 pandemic raises concerns about the mental health of the world population. Protection measures to prevention the…
Background: Despite increased testing efforts and the deployment of vaccines, COVID-19 cases and death toll continue to rise at record…
Introduction: Funding and staff formerly dedicated to routine public health tasks (e.g., responding to communicable and non-communicable…
Introduction: The spread of COVID-19 into a global pandemic has negatively affected the mental health of frontline healthcare-workers. This…
Background: People with severe mental ill health (SMI) experience a mortality gap of 15–20 years. COVID-19 has amplified population health…
A rapid stream of research confirms that the COVID-19 pandemic is a global threat to mental health and psychological well-being. It is…
Background: The Emergency Use Authorization (EUA) of remdesivir for coronavirus disease 2019 raised questions on transparency of applied…
Longstanding social and economic inequities elevate health risks and vulnerabilities for Black, Indigenous and People of Color (BIPOC)…
Brazil presents one of the highest COVID-19 death tolls in the world. The initial SARS-CoV-2 epicenter was São Paulo city. As of 2019, the…
The aim of this study was to evaluate the predictive value of the constructs proposed by two influential theoretical frameworks: the…
Individuals are dependent on institutions (e.g., universities, governments, healthcare systems) to protect their safety and advocate for…
During the initial phase of the COVID-19 pandemic, U.S. conservative politicians and the media downplayed the risk of both contracting…
A crucial question in the governance of infectious disease outbreaks is how to ensure that people continue to adhere to mitigation…
Background: According to the World Health Organization, viral diseases continue to emerge and represent a serious issue for public health.…
Objectives: Some studies suggested more COVID-19-associated hospitalizations among racial and ethnic minorities. To inform public health…
Laws not only affect behavior due to changes in material payoffs, but they may also change the perception individuals have of social…
Introduction: Twitter represents a mainstream news source for the American public, offering a valuable vehicle for learning how citizens…
Background: Teaching work is stressful, moreover during the pandemic teachers’ stress might have been intensified by distance education as…
Background: The effects of the COVID 19 pandemic on the mental health of citizens from Asia, Europe, or North America begin to be known,…
The present study examined individual characteristics potentially associated with changes in mitigation behaviors (social distancing and…
Background: LGBTQ2S youth are overrepresented among youth experiencing homelessness and experience significantly higher rates of mental…
Background and objectives: The COVID-19 pandemic has negatively impacted health systems worldwide, including in Bangladesh, limiting access…
Introduction: The widespread use of face masks by the general public may help to prevent the spread of viruses. Face masks are thought to…
Countermeasures against the spread of COVID-19 have become an urgent issue in educational settings, where many group activities are…
The COVID-19 pandemic is likely to have adverse effects on the economy through damage to migration and remittances. We use a unique…
Background: COVID-19 vaccine coverage in the Latinx community depends on delivery systems that overcome barriers such as institutional…
Background: Sequential Organ Failure Assessment (SOFA) score predicts probability of in-hospital mortality. Many crisis standards of care…
Background: Brazil, as many other countries, have been heavily affected by COVID-19. This study aimed to analyze the impact of Primary…
COVID-19 caused a global change in the lifestyles of people around the world. It provided a unique opportunity to examine how external…
Background: Overcrowded housing, as well as inadequate sanitary conditions, contribute to making homeless people particularly vulnerable to…
Objective: This study aimed to assess the prevalence and associated factors of post-traumatic stress disorder among health professionals…
Health Care Leaders (HCLs) faced unprecedented challenges during the initial phases of the COVID-19 pandemic. Leaders played an important…
Peter Figueroa and co-authors advocate for equity in the worldwide provision of COVID-19…
How do people balance concerns for general health and economic outcomes during a pandemic? And, how does the communication of this…
In response to the global COVID-19 epidemic, the United Arab Emirates (UAE) government is taking precautionary action to mitigate the…
Background: Prenatal care providers will play an important role in the acceptance of SARS-Cov-2 vaccination for pregnant women. Objective:…
Introduction: The COVID-19 pandemic has enormously affected the psychological well-being, social and working life of millions of people…
In the risky-choice framing effect, different wording of the same options leads to predictably different choices. In a large-scale survey…
Introduction: Misconception related to coronavirus disease-2019 (COVID-19) have been spread out broadly and the the World Health…
Background: COVID-19 vaccine hesitancy seems to be universal across countries and subgroups, and so are its determinants. We studied the…
Introduction: Adolescents living with HIV (ALHIV, ages 10–19) experience complex challenges to adhere to antiretroviral therapy (ART) and…
Background: The aim of this research was to investigate the impact of the first COVID-19 lockdown (March 17th—May 11th 2020) on violence…
Bangladesh govt. launched a nationwide vaccination drive against SARS-CoV-2 infection from early February 2021. The objectives of this…
COVID-19 pandemic has impacted people around the globe. Countries, including Indonesia, implemented large-scale social restrictions. Since…
Introduction: Community engagement (CE) is an effective public health strategy for improving health outcomes. There is limited published…
What influences the adoption of SARS-CoV-2 mitigation behaviors–both personal, such as mask wearing and frequent handwashing, and social,…
Background: Research on COVID-19 during pregnancy has mainly focused on women hospitalized for COVID-19 or other reasons during their…
Social role disruption is a state involving upheaval of social identities, routines and responsibilities. Such disruption is presently…
Background: The COVID-19 pandemic has placed a significant burden on the mental health and wellbeing of frontline health and social care…
Researchers and journalists have argued that work-related factors may be partly responsible for disproportionate COVID-19 infection and…
Background: Political ideologies drove public actions and health behaviors in the first year of the global pandemic. Different ideas about…
Objective: To understand racial bias in clinical settings from the perspectives of minority patients and healthcare providers to inspire…
Background: Healthcare providers are vulnerable in the fight against COVID-19 and may experience significant psychological and mental…
The COVID-19 pandemic might affect many aspects of the community and a range of psychiatric risk factors due to life changes, including…
Despite the greater adverse economic impacts in low and middle-income (LAMI) compared to high-income countries, fewer studies have…
Evidence suggests that non-binary people have poorer mental and physical health outcomes, compared with people who identify within the…
Background: The COVID-19 vaccination campaign in the US has been immensely successful in vaccinating those who are receptive, further…
In order to eliminate COVID-19, many countries provided vaccinations. However, success depends on peoples’ knowledge levels and rates of…
Parent-child conversations are important for children’s cognitive development, children’s ability to cope with stressful events, and can…
Background: Endometriosis is a chronic pain condition in premenopausal women. Pain is mainly characterized by pain intensity and may induce…
Background: Switzerland has a liberal implementation of Coronavirus mitigation measures compared to other European countries. Since March…
Notable cross-country differences exist in the diffusion of the Covid-19 and in its lethality. Contact patterns in populations, and in…
Coronavirus disease 2019 (COVID-19) has presented a global pandemic in 2020 and 2021, and has therefore spurred a flurry of research,…
The introduction of COVID-19 vaccines is a major public health breakthrough. However, members of US Black and Hispanic communities,…
Objectives: This study objectives were to investigate maternal psychological distress, mothers’ fear of their children contracting…
Background: While vaccines ensure individual protection against COVID-19 infection, delay in receipt or refusal of vaccines will have both…
Social distancing measures implemented by governments worldwide during the COVID-19 pandemic have proven an effective intervention to…
Despite the severe psychological impact of the COVID-19 pandemic, some individuals do not develop high levels of psychological distress…
Background: Coronavirus disease 2019 or COVID-19 is caused by a newly discovered coronavirus, SARS-CoV-2. The Malaysian government has…
The COVID-19 pandemic is an unprecedented public health crisis with broad social and economic consequences. We conducted four surveys…
Along with the major impact on public health, the COVID-19 outbreak has caused unprecedented concerns ranging from sudden loss of…
The importance of researching public support for preventive policies have been amplified by the COVID-19 pandemic. Using a representative…
Intensive care unit healthcare workers (ICU HCW) are at risk of mental health issues during emerging disease outbreaks. A study of ICU HCW…
Introduction: Illnesses requiring hospitalization are known to negatively impact psychological well-being and health-related quality of…
To achieve herd immunity against COVID-19, it is crucial to know the drivers of vaccination intention and, thereby, vaccination. As the…
Like other disease outbreaks, the COVID-19 pandemic has led to the rapid generation and dissemination of misinformation and fake news. We…
The U.S. with only 4% of the world’s population, bears a disproportionate share of infections in the COVID-19 pandemic. To understand this…
COVID-19 caused a significant public health crisis worldwide and triggered some other issues such as economic crisis, job cuts, mental…
Background: The 2019 coronavirus disease (COVID-19) pandemic resulted in the closure of businesses and schools, the remote provision of…
We predicted that people with compassionate goals to support others and not harm them practiced more COVID-19 health behaviors during the…
People experiencing homelessness (PEH) are at high risk for COVID-19 complications and fatality, and have been prioritized for vaccination…
Background: This study examines the association between food insecurity and mental health of women during the COVID-19 pandemic in a…
Aims: The present study aimed to investigate whether the psychological impact of the COVID-19 crisis varied with regards to young Swiss…
Objectives: There is limited evidence on how clinical outcomes differ by socioeconomic conditions among patients with coronavirus disease…
How and why do people comply with protective behaviours during COVID-19? The emerging literature employs a variable-centered approach,…
This study is to assess the influences of climate, socio-economic determinants, and spatial distance on the confirmed cases and deaths in…
Introduction: The COVID-19 pandemic resulted in severe detrimental effects on the mental well-being of health care workers (HCW).…
Following the 2019 coronavirus disease (COVID-19) outbreak in China, undergraduate students may experience psychological changes. During…
Objectives: The Covid-19 pandemic is hitting societies hard, and people living in disadvantaged circumstances are among the most affected.…
Objective: To evaluate factors associated with COVID-19 preventive health behaviors among adults in Mexico City and the State of Mexico.…
Background: Early studies on COVID-19 identified unequal patterns in hospitalization and mortality in urban environments for racial and…
Background: The efficacy of testing and tracing programs to reduce COVID-19 transmission hinges not only on widespread access to testing,…
Reopening amid the COVID-19 pandemic has triggered a battle on social media. The supporters perceived that the lockdown policy could…
Spain was, together with Italy, the first European country severely affected by the COVID-19 pandemic. After one month of strict lockdown…
The Chilean health authorities have implemented a sanitary strategy known as dynamic quarantine or strategic quarantine to cope with the…
Objective: Two randomized controlled experiments investigated if writing a narrative text about a fictional person who shows disapproved of…
Background: The COVID-19 pandemic led to mental health fallout in the US; yet research about mental health and COVID-19 primarily rely on…
Early in the pandemic, slowing the spread of novel coronavirus disease 2019 (COVID-19) relied on non-pharmaceutical interventions. All…
The spread of COVID-19 in the Spring of 2020 prompted state and local governments to implement a variety of policies, including…
Background: The 2019 coronavirus disease (COVID-19) epidemic is a global health emergency which has been shown to pose a great challenge to…
Background: The Covid-19 pandemic has had unprecedented effects on individual lives and livelihoods as well as on social, health, economic…
Background: During infectious disease outbreaks, healthcare workers are at high risk of infection, infecting others, and psychological…
Public health and social measures have been implemented around the world in a bid to prevent the spread of COVID-19. Public compliance…
Social liberals tend to be less pathogen-avoidant than social conservatives, a pattern consistent with a model wherein ideological…
Countries across the world responded to the COVID-19 pandemic with what might well be the set of biggest state-led mobility and activity…
Background: The COVID-19 pandemic and control measures adopted by countries globally can lead to stress and anxiety. Investigating the…
Introduction: During public health crises like the COVID-19 pandemic, populations can experience worsening mental health. Prior reports…
Purpose: Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly across the world. During the pandemic, physicians in…
Aim: This study aimed to assess the fear of COVID-19 and its associates among older Rohingya (Forcibly Displaced Myanmar Nationals or…
We extend previous studies on the impact of masks on COVID-19 outcomes by investigating an unprecedented breadth and depth of health…
Background: The COVID 19 pandemic created a global public health crisis. Physical distancing, masks, personal protective equipment worn by…
How does a public health crisis like a global pandemic affect political opinions in fragile democratic contexts? Research in political…
The COVID-19 pandemic has forced many governments to impose social distancing measures upon its citizens, including in the Netherlands.…
This study examines the evolution of Schwartz’s Basic Human Values during the COVID-19 outbreak, and their relationships with perceived…
More than 1.6 million Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) tests were administered daily in the United States at…
In March of 2020, the United States was confronted with a major public health crisis caused by the coronavirus disease (COVID-19). This…
Recent evidence suggests that psychological health deteriorated during the COVID-19 pandemic but far less is known about changes in other…
Background: Little is known about effects of COVID-19 lockdown on psychosocial factors, health and lifestyle in older adults, particularly…
Background: The increase in violence against health professionals in the COVID-19 pandemic makes it necessary to identify the predictors of…
Background: Carceral facilities are epicenters of the COVID-19 pandemic, placing incarcerated people at an elevated risk of COVID-19…
The COVID-19 global pandemic has had a socioeconomic effect, including many people suffering from stress and mental disorders. Health…
Introduction: Health care professionals are at higher risk of developing stress-related problems during outbreaks, due to the overwhelming…
Research efforts in the initial months of the COVID-19 pandemic focused on the actual and potential impacts on societies, economies,…
With the COVID-19 pandemic still raging and the vaccination program still rolling out, there continues to be an immediate need for public…
Introduction: In late 2019, a new coronavirus disease known as COVID-19 (novel coronavirus disease 2019) was identified. As there is no any…
Background: Preliminary empirical data indicates a substantial impact of the COVID-19 pandemic on well-being and mental health. Individuals…
Importance: Knowledge and attitude influence compliance and individuals’ practices. The risk and protective factors associated with high…
We compare the health and economic costs of early and delayed mandated suppression and the unmitigated spread of ‘first-wave’ COVID-19…
Background: In the fight against the COVID-19 pandemic, frontline healthcare providers who are engaged in the direct diagnosis, treatment,…
The magnitude and nature of the COVID-19 pandemic prevents public health policies from relying on coercive enforcement. Practicing social…
Introduction: COVID-19 is primarily a respiratory illness, and smoking adversely impacts the respiratory and immune systems; this…
Background: COVID-19 has exerted a variety of impacts on people, particularly people with limited education living in poor economic…
Introduction: Misinformation surrounding COVID-19 poses a global public health problem that adversely affects governments’ abilities to…
We collected COVID-19 epidemiological and epidemic control measures-related data in mainland China during the period January 1 to February…
Faced with the emergence of the Covid-19 pandemic, and to better understand and contain the disease’s spread, health organisations…
As countries are lifting restrictions and resuming international travels, the rising risk of COVID-19 importation remains concerning,…
Background: Mexican state governments’ actions are essential to control the COVID-19 pandemic within the country. However, the type, rigor…
Background: Since the start of the global COVID-19 pandemic, countries have been mirroring each other’s policies to mitigate the spread of…
Mass gathering events have been identified as high-risk environments for community transmission of coronavirus disease 2019 (COVID-19).…
Social distancing prescribed by policy makers in response to COVID-19 raises important questions as to how effectively people of color can…
Transparency of Chinese media coverage became an international controversy when the COVID-19 outbreak initially emerged in Wuhan, the…
Facing the COVID-19 pandemic, Taiwan demonstrated resilience at the initial stage of epidemic prevention, and effectively slowed down its…
The SARS-CoV-2 pandemic has emerged as one of the most dramatic health crises of recent decades. This paper treats mainstream news about…
The COVID-19 pandemic seems to be the most important phenomenon observed from March 2020 in virtually all countries of the world. The…
Worries associated with COVID-19 health consequences are well-justified. They may motivate people to take safety precautions, but may…
Background & aim: The coronavirus disease 2019 (COVID-19) pandemic has affected the life and work of people worldwide. The present study…
Background: Coronavirus disease 2019 (COVID-19) is currently the critical health problem of the globe, including Ethiopia. Visitors of…
We investigate the effectiveness of business shutdowns to contain the Covid-19 disease. In March 2020, Italy shut down operations in…
To reduce the spread of COVID-19 transmission, government agencies in the United States (US) recommended precautionary guidelines,…
Several vaccines against COVID-19 have now been developed and are already being rolled out around the world. The decision whether or not…
Lockdown curbs the COVID-19 epidemics but at huge costs. Public debates question its impact compared to reliance on individual…
Following the outbreak of COVID-19, governments took unprecedented measures to curb the spread of the virus. Public participation in…
As the Coronavirus-2019 (COVID-19) pandemic continues, multiple therapies are rapidly being evaluated for efficacy in clinical trials.…
Background: Due to the dramatic measures accompanying isolation and the general uncertainty and fear associated with COVID-19, patients and…
The social media milieu in which we are enmeshed has substantive impacts on our beliefs and perceptions. Recent work has established that…
Background: The emergence of a pandemic presents challenges and opportunities for healthcare, health promotion interventions, and overall…
A COVID-19 vaccine is the key to beating the virus, and effective vaccines are going to be available in the near future. It is urgent to…
Assessing individuals’ knowledge and preventive behaviors towards the Coronavirus Disease of 2019 (COVID-19) is essential for the related…
Background: The world is being challenged by the COVID-19 outbreak that resulted in a universal concern and economic hardship. It is a…
This paper investigates economic impacts of COVID-19 on households based on differences in the socio-economic status (SES). We determine…
Background: Risk communication is a key component of public health interventions during an outbreak. As the coronavirus pandemic unfolded…
In recent times, many alarm bells have begun to sound: the metaphorical presentation of the COVID-19 emergency as a war might be…
The coronavirus disease 2019 (COVID-19) has caused an unprecedented public health crisis worldwide. Its intense politicization constantly…
Coronavirus disease 2019 (COVID-19) infection has become a clinical threat to healthy people as well as immunocompromised patients and…
The present study examined the daily well-being of Koreans (n = 353,340) for 11 weeks during the COVID-19 pandemic (January 20 –April 7).…
Vaccines are effective interventions that can reduce the high burden of diseases globally. However, public vaccine hesitancy is a pressing…
Seye Abimbola and co-authors argue for a transformation in global health research and practice in the post-COVID-19…
Due to the sudden emergence of the novel coronavirus as a worldwide pandemic, this study aimed to evaluate the awareness and practices of…
The COVID-19 pandemic has unleashed multiple public health, socio-economic, and institutional crises. Measures taken to slow the spread of…
It is critical to gain an understanding of the impact of the COVID 19 pandemic and the associated lockdown restrictions on the…
Studies of citizens’ compliance with COVID-19 preventive measures routinely rely on survey data. While such data are essential, public…
We use survey data collected from 12,037 US respondents to examine the extent to which the American public believes that political motives…
SARS-CoV-2 disease 2019 (COVID-19) is pandemic and currently becomes a serious cause of death worldwide. It is caused by a SARS-CoV-2…
The COVID-19 pandemic has caused severe health and economic impacts globally. Strategies to safely reopen economies, travel and trade are…
In attempts to control the spread of the Covid-19 virus, many governments have resorted to imposing national lockdowns on their citizens.…
Background: Knowledge, attitudes, perception, and preventative practices regarding coronavirus- 2019 (COVID-19) are crucial in its…
The Covid-19 pandemic has placed unprecedented pressure on healthcare systems and workers around the world. Such pressures may impact on…
Introduction: The COVID-19 pandemic has compounded the global crisis of stress and burnout among healthcare workers. But few studies have…
Background: Given the economic and social divide that exists in South Africa, it is critical to manage the health response of its residents…
Background: COVID-19 is the novel coronavirus responsible for the ongoing global outbreak of acute respiratory disease and viral pneumonia.…
How do attitudes toward vaccination change over the course of a public health crisis? We report results from a longitudinal survey of…
Background: COVID-19 threatens health systems worldwide, but Venezuela’s system is particularly vulnerable. To prevent the spread of…
Background: Acute augmentation of stress and disruption of training, such as during the COVID-19 pandemic, may impact resident wellbeing.…
Background: The COVID-19 pandemic has intensely changed the everyday lives of people worldwide. This study explores the forms and outcomes…
Public health agencies have suggested nonpharmaceutical interventions to curb the spread of the COVID-19 infections. The study intended to…
Along with the plight of the COVID-19 outbreak in 2020 come the xenophobic behaviors and hate crimes against people with Asian descent…
Objective: To study the U.S. public’s health behaviors, attitudes, and policy opinions about COVID-19 in the earliest weeks of the national…
Rational: During pandemics, including the most recent COVID-19 pandemic, the mental health of university healthcare students’ is expected…
The world continues to face a life-threatening viral pandemic. The virus underlying the Coronavirus Disease 2019 (COVID-19), Severe Acute…
This study aims at investigating the nature of resilience and stress experience of health care workers during the COVID-19 pandemic.…
Objectives: To characterize psychological distress and factors associated with distress in healthcare practitioners working during a…
In response to the pandemic in early 2020, cities implemented states of emergency and stay at home orders to reduce virus spread. Changes…
The COVID-19 pandemic has caused significant disruption, distress, and loss of life around the world. While negative health, economic, and…
International scientific collaborations have always been regarded as critical actions to address global pandemics, however, there was an…
Early reports indicate that the social determinants of health are implicated in COVID-19 incidence and outcomes. To inform the ongoing…
Since the World Health Organization (WHO) announced that the coronavirus disease (COVID-19) is a worldwide pandemic, many countries’…
Pandemics have historically had a significant impact on economic inequality. However, official inequality statistics are only available at…
Objectives: Existing literature on how employment loss affects depression has struggled to address potential endogeneity bias caused by…
Background: Nursing homes (NH) for the elderly have been particularly affected by the Covid-19 pandemic mainly due to their hosted…
This study aimed to investigate the characteristics related to SARS-CoV-2 in Luanda, Angola. A total of 622 individuals were screened for…
We study the gender differences in aversion to COVID-19 exposure using a natural experiment of the 2020 US Open. It was the first major…
Background: High levels of vaccination coverage in populations will be required even with vaccines that have high levels of effectiveness…
Background: The COVID-19 pandemic has been creating a panic and distressing situations among the entire population globally including…
Owing to the rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic worldwide, individuals experience…
Purpose: Primary objective of this study was to identify potential difficulties and/or discomfort when using a facemask. Moreover, to…
Building on the epidemiological SIR model, we present an economic model with heterogeneous individuals deriving utility from social…
The spread of COVID-19 and resulting local and national lockdowns have a host of potential consequences for demographic trends. While…
This study aimed to investigate the knowledge, practices, and attitudes of medical professionals toward Traditional Chinese Medicine (TCM)…
Purpose: Virus epidemics may be mitigated if people comply with directives to stay at home and keep their distance from strangers in…
Background: Coronavirus disease 2019 (COVID-19) is a highly contagious viral infection, and it has negative effects on public health. The…
The novel Coronavirus SARS-CoV-2 (COVID-19) is a global pandemic with an increasing public health concern. Due to the non-availability of…
COVID-19 has led to global dramatic shifts in daily life. Following the biopsychosocial model of health, the goal of the current study was…
The emergence of Coronavirus disease 2019 (COVID-19) has affected health-care workers’ psychological and mental health. Few studies have…
The coronavirus pandemic has seen a marked rise in medical disinformation across social media. A variety of claims have garnered…
False news stories cause welfare losses and fatal health consequences. To limit its dissemination, it is essential to know what determines…
Introduction: Across the world, the COVID-19 pandemic has disproportionately affected racial and ethnic minorities. How ethnicity affects…
Objective: The COVID-19 pandemic has placed health care workers under psychological stress. Previous reviews show a high prevalence of…
In the ongoing COVID-19 pandemic, public health experts have produced guidelines to limit the spread of the coronavirus, but individuals…
The worldwide spread of a new coronavirus (SARS-CoV-2) since December 2019 has posed a severe threat to individuals’ well-being. While the…
Despite the vast scientific evidence obtained from the genomic sequencing of COVID-19, controversy regarding its origin has been created…
This research note introduces a new global dataset, the Citizenship, Migration and Mobility in a Pandemic (CMMP). The dataset features…
As the vaccines against COVID are slowly becoming available, we need to consider the paradox of why so many people of color are dying from…
Testing and case identification are key strategies in controlling the COVID-19 pandemic. Contact tracing and isolation are only possible…
Introduction: With over 500 000 infections and nearly 12 000 deaths, South Africa (SA) is the African epicenter of the current Coronavirus…
Background: Healthcare facilities in Ethiopia are responsible for collecting samples for testing and treating COVID-19 patients, providing…
The COVID-19 pandemic has been followed intensely by the global news media, with deaths and bereavement a major focus. The media reflect…
Population ageing requires society to adjust by ensuring additional types of services and assistance for elderly people. These may be…
We construct a novel database containing hundreds of thousands geotagged messages related to the COVID-19 pandemic sent on Twitter. We…
Vaccinations are without doubt one of the greatest achievements of modern medicine, and there is hope that they can constitute a solution…
While effective preventive measures against COVID-19 are now widely known, many individuals fail to adopt them. This article provides…
We discuss the impact of a Covid-19–like shock on a simple model economy, described by the previously developed Mark-0 Agent-Based Model.…
Background: Identified in December 2019 in the city of Wuhan, China, the outbreak of COVID-19 spread throughout the world and its impacts…
The dramatic changes in people’s daily lives caused by the 2019 coronavirus (COVID-19) pandemic have had a huge impact on their emotions…
Objective: The COVID-19 pandemic continues to pose significant challenges to nations. The Korean government aimed to mitigate the spread of…
The spread of Covid-19 has resulted in worldwide health concerns. Social media is increasingly used to share news and opinions about it. A…
Background: The Chinese government’s early handling of COVID-19 has been perceived as aggressive and oppressive. Many of the most radical…
The purpose of this work is to provide an effective social distance monitoring solution in low light environments in a pandemic situation.…
The COVID-19 pandemic likely had an effect on the outcome of the 2020 US presidential election. Was it responsible for the defeat of…
This article investigates the effects of the COVID-19 outbreak on electoral participation. We study the French municipal elections that…
A study involving over 2000 online participants (US residents) tested a general framework regarding compliance with a directive in the…
Societal responses to crises require coordination at multiple levels of organization. Exploring early efforts to contain COVID-19 in the…
Public health measures to reduce COVID-19 transmission include masking in public places, physical distancing, staying home when ill,…
Community face masking is possibly of great value in reducing COVID-19 transmission, especially when universally adopted with high…
The health risk of the coronavirus pandemic is age-specific. The symptoms of a COVID-19 infection are usually mild in the healthy…
The explosion of disinformation accompanying the COVID-19 pandemic has overloaded fact-checkers and media worldwide, and brought a new…
Objective: In 2020, the COVID-19 appeared in Italy with an exponential transmission capacity and serious consequences for the whole…
We analyze the trade-offs between health and the economy during the period of social distancing in São Paulo, the state hardest hit by the…
This study reports a comprehensive empirical investigation of the nature and correlates of anti-mask attitudes during the COVID-19…
The coronavirus disease (COVID-19) pandemic has impacted the economy, livelihood, and physical and mental well-being of people worldwide.…
Background: The World Health Organization has declared that infection with SARS-CoV-2 is a pandemic. Experiences with SARS in 2003 and…
The aim of this study was to examine aspects of children’s health literacy; the information sources they were accessing, their information…
Healthcare workers (HCWs) are at the frontline of the Coronavirus Disease 2019 (COVID-19) pandemic response, yet there is a paucity of…
Background: COVID-19 pandemic has provoked a wide variety of psychological problems such as anxiety, depression, and panic disorders,…
Assessing fear and anxiety regarding COVID-19 viral infection is essential for investigating mental health during this epidemic. We have…
Background: During the catastrophic situation of the COVID-19 pandemic, the role of the health care workers (HCWs) is the most crucial, and…
Background: Healthcare workers are at increased risk of adverse mental health outcomes during the COVID-19 pandemic. Studies are warranted…
It is urgent to understand how to effectively communicate public health messages during the COVID-19 pandemic. Previous work has focused…
The COVID-19 pandemic has become one of the main international concerns regarding its impact on mental health. The present study aims to…
COVID-19 was declared a pandemic on March 12, 2020. Italy has been the most affected country in the world, right after China. Healthcare…
Guinea, like many other African countries, has been facing an unprecedented COVID-19 outbreak, since March 2020. In April 2020, Guinean…
The novel coronavirus (COVID-19) infection has spread worldwide since late 2019. People who have social contacts with COVID-19 patients…
Introduction: COVID-19 incidence is increasing and different measures have been adopted to control the spread of the pandemic in Ethiopia.…
Why have the effects of COVID-19 been so unevenly geographically distributed in the United States? This paper investigates the role of…
Background: The disease from the novel coronavirus (COVID-19) has been considered as an international concern and a pandemic starting from…
The COVID-19 pandemic, the accompanying lockdown measures, and their possible long-term effects have made mental health a pressing public…
The COVID-19 pandemic and government imposed social restrictions like lockdown exposed most individuals to an unprecedented stress,…
Background: Waiters working in different food and drinking establishments have a higher risk of contracting COVID-19 and transmitting the…
Amidst the rapid global spread of Covid-19, many governments enforced country-wide lockdowns, with likely severe well-being consequences.…
Objective: To investigate the association among social media exposure, risk perception, preventive behaviors, and attitudes toward the…
The nature of the COVID-19 pandemic may require governments to use privacy-encroaching technologies to help contain its spread. One…
Introduction: Coronavirus disease 2019 (COVID-19) is an emerging respiratory infections and is known to cause illness ranging from the…
In response to the COVID-19 pandemic, many Governments are instituting mobile tracking technologies to perform rapid contact tracing.…
COVID-19 abatement strategies have risks and uncertainties which could lead to repeating waves of infection. We show—as proof of concept…
To slow the transmission of COVID-19, countries around the world have implemented social distancing and stay-at-home policies—potentially…
We investigated what degree of risk of infection with COVID-19 is necessary so that people intend to stay home, even when doing so means…
Background: The SARS-CoV-2 virus has spread rapidly around the globe since December 2019 creating much uncertainty among medical staff. Due…
Background: A pandemic of coronavirus disease 2019 (COVID-19) emerged and affected most of the world in early 2020. To inform effective…
Background: The U.S. has experienced an unprecedented number of orders to shelter in place throughout the ongoing COVID-19 pandemic. We…
Background: The burden of psychological distress is increasing with the spread of the pandemic and also with the enforcement of its…
Background: To combat social distancing and stay-at-home restrictions due to COVID-19, Canadian communities began a Facebook social media…
Background: The COVID-19 epidemic in the United States is widespread, with more than 200,000 deaths reported as of September 23, 2020.…
The aim of the present study was to investigate the psychological effects of the COVID-19 outbreak and associated factors on hospital…
The COVID-19 pandemic does not fit into prevailing Post-traumatic Stress Disorder (PTSD) models, or diagnostic criteria, yet emerging…
Background: The COVID-19 virus impacts human health and the world economy, causing in Peru, more than 800 thousand infected and a strong…
Background: The COVID-19 pandemic is impacting the global community in many ways. Combating the COVID-19 pandemic requires a coordinated…
Antisocial behaviors cause harm, directly or indirectly, to others’ welfare. The novel coronavirus pandemic has increased the urgency of…
Background: University students are increasingly recognized as a vulnerable population, suffering from higher levels of anxiety,…
Objectives: Examine the effects of the COVID-19 pandemic on the mental health and loneliness in the general population. More specifically,…
We use the UK Household Longitudinal Study and compare pre-COVID-19 pandemic (2017-2019) and during-COVID-19 pandemic data (April 2020)…
In confronting the global spread of the coronavirus disease COVID-19 pandemic we must have coordinated medical, operational, and political…
Coronavirus disease 2019 (COVID-19) is a highly contagious illness that spreads rapidly through human-to-human transmission. On March 5,…
Background: Multiple studies have highlighted the negative impact of COVID-19 and its particular effects on vulnerable sub-populations.…
We conducted a rapid, mixed-methods assessment to understand how COVID-19 affected Latinx sexual minority men (LSMM) and transgender women…
In this paper we explore whether countries led by women have fared better during the COVID-19 pandemic than those led by men. Media and…
Social distancing measures have been implemented in many countries to limit the spread of COVID-19. Emerging literature reveals that fear…
State “shelter-in-place” (SIP) orders limited the spread of COVID-19 in the U.S. However, impacts may have varied by state, creating…
Background: The COVID-19 pandemic triggered vast governmental lockdowns. The impact of these lockdowns on mental health is inadequately…
Background: In response to the coronavirus diseases 2019 (COVID-19) pandemic, the Japanese government declared a state of emergency on…
Background: Considering its pandemicity and absence of effective treatment, authorities across the globe have designed various mitigation…
Background: People with disabilities face multiple barriers that prevent them from accessing care and essential information related to the…
This paper reports the results of a Bayesian analysis on large-scale empirical data to assess the effectiveness of eleven types of…
Background: COVID-19 rapidly escalated into a pandemic, threatening 213 countries, areas, and territories the world over. We aimed to…
Background: The Coronavirus Disease 2019 (COVID-19) outbreak has escalated the burden of psychological distress. We aimed to evaluate…
Objective: To explore parents’ and guardians’ views and experiences of accessing National Health Service (NHS) general practices for…
Objective: To study the U.S. public’s attitudes toward surveillance measures aimed at curbing the spread of COVID-19, particularly…
To slow the progression of COVID-19, the Centers for Disease Control (CDC) and the World Health Organization (WHO) have recommended…
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new strain of virus in the Coronavirus family that has not been…
Objective: This study aimed to investigate the anxiety levels of healthcare workers and to provide guidance on potential accurate social…
With the COVID-19 pandemic infecting millions of people, large-scale isolation policies have been enacted across the globe. To assess the…
Objective: To evaluate differences by race/ethnicity in clinical characteristics and outcomes among hospitalized patients with Covid-19 at…
The coronavirus disease (COVID-19) pandemic has greatly altered peoples’ daily lives, and it continues spreading as a crucial concern…
Background: The COVID-19 pandemic has negatively affected physical and mental health worldwide. Pregnant women already exhibit an elevated…
…
It is known that the new coronavirus (COVID-19) is disproportionately affecting the elderly, those with underlying medical conditions, and…
Background: Vietnam applied strict quarantine measures to mitigate the rapid transmission of the SARS-COV-2 virus. Central questions were…
Objectives: To explore coronavirus disease 2019 (COVID-19)-related stigma and its associated factors among Egyptian physicians. Methods: A…
Urban, peri-urban forests and other natural areas provide a wide range of material and non-material benefits to people known as ecosystem…
The global epidemic of (mis)information, spreading rapidly via social media platforms and other outlets, can be a risk factor for the…
Social trust has been an important mechanism in overcoming crises throughout history. Several societies are now emphasizing its role in…
On March 24, 2020 India implemented a national lockdown to prevent spread of the novel Coronavirus disease (COVID-19) among its 1.3…
The coronavirus pandemic led to a severe economic shock in the United States. This paper uses a unique survey data collected early on in…
Introduction: The novel Coronavirus Disease (COVID-19) outbreak currently puts health care workers at high risk of both physical and mental…
Background: In the past infectious diseases affected the quality of lifestyle during home confinement. The study conducted examines the…
Background: The coronavirus disease of 2019 (COVID-19) represents a difficult challenge and could have devastating consequences for the…
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an emergent infectious pathogen causing an acute respiratory disease…
Background: On account of the COVID-19 pandemic, many changes have been implicated in university medical students. We are cognizant that…
Converging empirical evidence indicates that exposure to adversity in childhood is associated with increased vulnerability to mental…
Purposes: Since a considerable number of health care workers (HCWs) were sent to Wuhan to aid COVID-19 control during the epidemic,…
The biggest nationwide COVID-19 pandemic lockdown worldwide was enforced in India for an initial period of 21-days. Emerging evidence…
To clarify the physical and mental conditions of children during the coronavirus disease 2019 pandemic and consequent social distancing in…
Objectives: The outcome of well-performed clinical research is essential for evidence-based patient management during pandemics. However,…
Background: Until now, no vaccine or effective drug is available for the control, prevention, and treatment of COVID-19. Preventive…
Exponential growth bias is the phenomenon whereby humans underestimate exponential growth. In the context of infectious diseases, this…
This study intends to explore the predictors of misconceptions, knowledge, attitudes, and practices concerning the COVID-19 pandemic among…
The COVID-19 pandemic has interrupted everyday life virtually everywhere in the world, enabling real-life research on threat-and-defense…
Background: The World Health Organization declared the outbreak of COVID-19 as a pandemic on 11 March 2020. Healthcare workers are directly…
In the context of the Covid-19 pandemic, barrier gestures such as regular hand-washing, social distancing, and wearing a face mask are…
Behavioral measures, such as the wearing of facemasks and maintaining of distance to other people, have been central in fighting the…
Introduction: Coronavirus disease 2019 (COVID-19) is an acute respiratory infection caused by novel coronavirus 2019. Many individuals…
Since the emergence of the recent coronavirus disease 2019 (COVID-19) and its spread as a pandemic, media was teeming with misinformation…
In this study, the spread of virus infection was simulated using artificial human networks. Here, real-space urban life was modeled as a…
Background: Louisiana in the summer of 2020 had the highest per capita case count for COVID-19 in the United States and COVID-19 deaths…
Nations struggled to decide when and how to end COVID-19 inspired lockdowns, with sharply divergent views between those arguing for a…
With the spread of COVID-19, more countries now recommend their citizens to wear facemasks in public. The uptake of facemasks, however,…
Background: The endeavor to tackle the spread of COVID-19 effectively remains futile without the right grasp of perceptions and beliefs…
The current global threat brought on by the Covid-19 pandemic has led to widespread social isolation, posing new challenges in dealing…
Background: Coronavirus disease-19 (COVID-19) has not only spawned a lot of stigma and discrimination towards its survivors but also to…
The Novel-coronavirus disease-2019 (COVID-2019) outbreak was declared a national emergency on March 13, 2020. To reduce the spread of the…
Introduction: Cancer care is significantly impacted by the Coronavirus Disease 2019 (COVID-19) pandemic. Our objective was to evaluate the…
With the wake of the COVID-19 pandemic, the question of society’s capability to deal with an acute health crisis is, once again, brought…
Background: Epidemiological studies during the early phase of the coronavirus (COVID-19) pandemics reported different level of people’s…
During the state of alarm declared in Spain by COVID-19 due to the pandemic, the country's authorities declared Social Services and their…
This survey-based study aimed to explore the mental health status and psychological care needs of 933 health-care workers in Italy during…
Objectives: To examine the potential moderating effects of explicit racial attitudes and implicit racial attitudes on the relationship…
The coronavirus disease-19 (COVID-19) pandemic represents a worldwide emergency, which may have harmful consequences on people’s mental…
It has been two months since Wuhan eased the lockdown and the people of Wuhan have been under great pressure during COVID-19. The…
COVID-19 emerged in November 2019 leading to a global pandemic that has not only resulted in widespread medical complications and loss of…
Background: The COVID-19 pandemic challenges societies in unknown ways, and individuals experience a substantial change in their daily…
Despite the profound health and economic implications of Covid-19, there is only limited knowledge to date about the role of economic…
The COVID-19 pandemic has had tremendous impact on Americans’ lives including their personal and social behaviors. While people of all…
We create a network model to study the spread of an epidemic through physically proximate and accidental daily human contacts in a city,…
The current COVID-19 pandemic raises concerns worldwide, leading to serious health, economic, and social challenges. The rapid spread of…
Background: A debate about the scientific quality of COVID-19 themed research has emerged. We explored whether the quality of evidence of…
Background: Public health recommendations and government measures during the COVID-19 pandemic have enforced restrictions on daily-living.…
COVID-19 is spreading worldwide, causing various social problems. The aim of the present study was to verify the reliability and validity…
The mandatory home confinement of the Spanish population, implemented in response to the COVID-19 pandemic, presents a unique opportunity…
Since the beginning of the year, the world’s attention has rightly been focused on the spread of the Coronavirus Disease 2019 (COVID-19)…
The general public is subject to triage policies that allocate scarce lifesaving resources during the COVID-19 pandemic, one of the worst…
New Zealand’s early response to the novel coronavirus pandemic included a strict lockdown which eliminated community transmission of…
Background: The COVID-19 pandemic is an unprecedented public health threat, both in scope and response. With no vaccine available, the…
Social distancing resulting from the new coronavirus (SARS-CoV2) has disrupted the airplane boarding process. Social distancing norms…
Objectives: To investigate whether people who think they have had COVID-19 are less likely to report engaging with lockdown measures…
The past nine months witnessed COVID-19's fast-spreading at the global level. Limited by medical resources shortage and uneven facilities…
Objective: Poor housing conditions have been linked with worse health outcomes and infectious disease spread. Since the relationship of…
At the beginning of the COVID-19 pandemic (10–14 March, 2020) we conducted a survey (n = 1028) of a nationally representative sample (age,…
Objective: This study was designed to determine risk perception and precautionary health behavior toward coronavirus disease (COVID-19)…
Objectives: According to current reporting, the number of active coronavirus disease 2019 (COVID-19) infections is not evenly distributed,…
Background: Black, Asian and minority ethnic (BAME) populations are emerging as a vulnerable group in the severe acute respiratory syndrome…
The COVID-19 pandemic puts health workers at increased risk of adverse mental health outcomes. However, no studies have assessed health…
Introduction: Efforts to mitigate the global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing Corona…
Kidney disease is a recognised risk factor for poor COVID-19 outcomes. Up to 30 June 2020, the UK Renal Registry (UKRR) collected data for…