Welcome to Autophagy and Proteostasis: A PLOS ONE Call for Papers


– Guest Editors –

Sharon Tooze

Thorsten Hoppe

Fulvio Reggiori

– Call for papers for a PLOS ONE Collection –


PLOS ONE is happy to announce a call for papers on the subject of Autophagy and Proteostasis. Autophagy is an evolutionarily conserved pathway for the degradation and recycling of cellular components and contributes to maintaining cellular quality control and homeostasis. Since autophagy was first described in the 1960s this field has grown rapidly because of the diversity of intracellular cargoes and mechanisms involved. More recently, there has been an increased focus on the importance of autophagy in the context of proteostasis in maintaining normal physiology and the role dysregulation plays in aging and diseases associated with aging such as neurodegenerative diseases or cancer.
We invite submissions that provide insight into the molecular and cellular machinery and mechanisms that regulate autophagy and the crosstalk with other protein quality control pathways to ensure proteostasis. We particularly welcome submissions that provide insight into the role these processes play in pathophysiological conditions and aging, as well as the modifying role diet and exercise can play in regulating autophagy and proteostasis.
Potential topics Include:

  • Upstream events involved in initiating and regulating autophagy and proteostasis pathways, such as starvation, cellular stress or unfolded protein response including cell non-autonomous regulation of these processes
  • Early initiation steps in macroautophagy including the formation of the phagophore assembly site (PAS) and the phagophore
  • Biogenesis of the autophagosomal membrane and regulators of autophagosome maturation and fusion with the lysosome
  • Mechanisms involved in selective types of autophagy such as mitophagy and ER-phagy, and the cargo receptors involved to ensure specificity and exclusivity.
  • Molecular machinery, regulation and mechanisms involved in chaperone-mediated autophagy and microautophagy
  • Interplay between the ubiquitin proteasome system and autophagy
  • Autophagy as a cell death process and its crosstalk with other cell death pathways
  • The interplay between autophagy and aging
  • Autophagy and proteostasis dysregulation in aging-associated diseases such as neurodegenerative disorders and cancer

PLOS ONE accepts scientifically rigorous research, regardless of perceived impact. PLOS ONE’s broad scope provides a platform to publish primary research, including interdisciplinary and replication studies, as well as negative results. The journal’s publication criteria are based on high ethical standards and the rigor of the methodology and conclusions reported.

Meet the Editors

Sharon Tooze

Guest Editor, PLOS ONE

Sharon Tooze is a Senior Group Leader at the Francis Crick Institute, London, UK. She has a long-standing interest in understanding organelle biogenesis using molecular cell biology approaches. Sharon received her PhD and undertook a postdoctoral research position in Wieland Huttner’s lab at the European Molecular Biology Laboratory (EMBL). She established a lab at Imperial Cancer Research Fund, UK which later became known as the Cancer Research UK London Research Institute. In 2015 she moved her lab to the Francis Crick Institute where her research continues to focus on autophagy. Her current interests are focused on expanding our knowledge of the core autophagy proteins in mammalian cells at the molecular level, in particular the autophagy proteins which initiate the formation of the autophagosome.


Thorsten Hoppe

Guest Editor, PLOS ONE

Thorsten Hoppe is a Professor at the Institute for Genetics and the Center for Aging Research (CECAD) at the University of Cologne, Germany. He received his PhD from the University of Heidelberg working in the lab of Stefan Jentsch at the Center for Molecular Biology in Heidelberg (ZMBH) and the Max Planck Institute of Biochemistry in Martinsried. He undertook is postdoctoral work in the Department of Molecular Neurogenetics in the group of Ralf Baumeister at the LM-University of Munich before setting up his own group in 2003 at the Centre for Molecular Neurobiologie at the University of Hamburg (ZMNH). In 2008 he moved his lab to the Institute for Genetics and was Acting Director from 2011 to 2013. His research focuses on understanding the role proteostasis plays in aging and age-associated diseases.

Fulvio Reggiori

Guest Editor, PLOS ONE

Fulvio Reggiori is a Professor and Section Head of Molecular Cell Biology at the Department of Biomedical Sciences of Cells and Systems of the University Medical Centre Groningen, The Netherlands. Fulvio obtained in his PhD in Biochemistry from the University of Fribourg, Switzerland, in the laboratory of Professor Andreas Conzelmann. Subsequently, he moved to the MRC Laboratory in Molecular Biology in Cambridge to join the laboratory of Dr. Hugh Pelham, UK in 1998. In 2001, Fulvio moved to the University of Michigan in Ann Arbor, USA to the laboratory of Professor Daniel Klionsky, where he started working on different aspects of the molecular mechanisms of autophagy in yeast. In 2005 he was appointed as an Assistant Professor at the Department of Cell Biology of the University Medical Center Utrecht, The Netherlands before becoming an Associate Professor in 2011. Fulvio moved his lab in 2015, to the Department of Department of Biomedical Sciences of Cells and Systems of the University Medical Center Groningen where he became Professor. His research continues to investigate the molecular mechanisms of autophagy using Saccharomyces cerevisiae as a model organism as well as understanding the interaction between autophagy and pathogens, in particular viruses.


PLOS ONE Handling Editors

Diane Bassham Aldrin V. Gomes Joseph Mancias* Shigeomi Shimizu
Christopher Brett Daniel Kaganovich Manoj Menon* Rajasekaran Soorappan
Jeffrey Brodsky Elise Kikis Oscar Millet Vladimir Trajkovic*
Santosh Chauhan Natalia Kononenko* Bertrand Mollereau Andrey Tsvetkov
Charleen T. Chu Weidong Le Michael Muders Ilya Ulasov*
Cory Dunn* Hyunjung Jade Lim* Ivan Nabi Neeraj Vij
Mariola Edelmann Kah-Leong Lim Stefanie Pöggeler Simon Wilkinson*
Rodrigo Franco* Paloma Liton* Andreas Reichert Stephan Witt*
Saeid Ghavami* Sandra Maday Kasper Rouschop Xu-jie Zhou*
Spencer Gibson Carl Maki Han-Ming Shen  

* Also acting as a Preprint Editor, searching relevant preprint servers and inviting suitable manuscripts to PLOS ONE with a guarantee of peer review.

Publishing Process

We aim to be as transparent as possible about our publishing and peer review processes. Papers submitted to PLOS ONE and under consideration for the Autophagy and Proteostasis Collection will be specially handled by hand-selected active researchers from our Editorial Board working in cell biology research, in partnership with PLOS ONE Senior Editor Nicola Stead.

For more information please see the PLOS ONE Editorial and Peer Review Information page

Submission Instructions

Articles must be submitted by August 19, 2019. 

Are you ready to submit or want to learn more about how the submission process works? To make it as easy as possible for our communities, all PLOS ONE submission instructions are posted online. If there are any details you can’t find, please email us at

Authors should specify the Call for Papers, “Autophagy and Proteostasis,” in their cover letter and, additionally for  PLOS ONE, in the ‘Collections’ field under ‘Additional Information’ on the submission form.

Highly Cited PLOS Papers in Autophagy and Proteostasis Research

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Authors: Derek P. Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A. Gautier, Jie Shen, Mark R. Cookson, Richard J. Youle

Published: January 26, 2010

The Association of AMPK with ULK1 Regulates Autophagy

Authors: Jong Woo Lee, Sungman Park, Yoshinori Takahashi, Hong-Gang Wang

Published: November 3, 2010

Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1

Authors: Chengqun Huang, Allen M. Andres, Eric P. Ratliff, Genaro Hernandez, Pamela Lee, Roberta A. Gottlieb 

Published: June 8, 2011

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

Authors: Guido Krebiehl, Sabine Ruckerbauer, Lena F. Burbulla, Nicole Kieper, Brigitte Maurer, Jens Waak, Hartwig Wolburg, Zemfira Gizatullina, Frank N. Gellerich, Dirk Woitalla, Olaf Riess, Philipp J. Kahle, Tassula Proikas-Cezanne, Rejko Krüger 

Published: February 23, 2010

The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation

Authors: Lin Qi, Xing-Ding Zhang, Jun-Chao Wu, Fang Lin, Jin Wang, Marian DiFiglia, Zheng-Hong Qin 

Published: October 11, 2012

Starvation Induced Cell Death in Autophagy-Defective Yeast Mutants Is Caused by Mitochondria Dysfunction

Authors: Sho W. Suzuki, Jun Onodera, Yoshinori Ohsumi

Published: February 25, 2011

Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

Authors: Kelly Devereaux, Claudia Dall’Armi, Abel Alcazar-Roman, Yuta Ogasawara, Xiang Zhou, Fan Wang, Akitsugu Yamamoto, Pietro De Camilli, Gilbert Di Paolo 

Published: October 3, 2013

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

Authors: Yousuf O. Ali, Hunter M. Allen, Lei Yu, David Li-Kroeger, Dena Bakhshizadehmahmoudi, Asante Hatcher, Cristin McCabe, Jishu Xu, Nicole Bjorklund, Giulio Taglialatela, David A. Bennett, Philip L. De Jager, Joshua M. Shulman, Hugo J. Bellen, Hui-Chen Lu 

Published: June 2, 2016

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

Authors: Jae Ho Seo, Dayana B. Rivadeneira, M. Cecilia Caino, Young Chan Chae, David W. Speicher, Hsin-Yao Tang, Valentina Vaira, Silvano Bosari, Alessandro Palleschi, Paolo Rampini, Andrew V. Kossenkov, Lucia R. Languino, Dario C. Altieri 

Published: July 7, 2016

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