collection
Cancer Metastasis
Cancer metastasis is responsible for 90% of all cancer deaths. The metastatic cascade is a multistep and sequential process involving cancer cell invasion, intravasation, circulation and colonization. However, our knowledge of the molecular and biochemical mechanisms that govern this process are still poorly understood. Furthermore, there is an urgent need to develop therapeutic interventions that target each part of the cascade.
Image Credit: Flickr
Guest Editors
-
PLOS ONE Joe Ramos
-
PLOS ONE Shengyu Yang
-
PLOS ONE Helen Fillmore
-
PLOS ONE Tobias Zech
PLOS ONE Collection
-
PLOS ONE The role of the immunoescape in colorectal cancer liver metastasis
The expression of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) indicate the efficacy of anti-PD-1/PD-L1 therapy in…
-
PLOS ONE Clinicopathological significance of the EMT-related proteins and their interrelationships in prostate cancer. An immunohistochemical study
The chronic inflammation influences a microenvironment, where as a result of losing control over tissue homeostatic mechanisms, the…
-
PLOS ONE Clinical and ultrasonographic features of choroidal metastases based on primary cancer site: Long-term experience in a single center
Introduction and purpose: Choroidal metastases (CM) are the most common intraocular malignancies. With longer survival rates for cancer…
-
PLOS ONE Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis
Methylation of the HLTF gene in colorectal cancer (CRC) cells occurs more frequently in men than women. Progressive epigenetic silencing…
-
Image creditPurple cells by National Cancer Institute, CC BY 4.0PLOS ONE Treatment of 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 inhibits TNF-alpha-mediated expression of MMP-9 protein and cell invasion through the suppression of JNK pathway and microRNA 221 in human pancreatic adenocarcinoma cancer cells
Human pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer type with a very high mortality rate. Inflammatory cytokine such as tumor…
-
PLOS ONE Harmine inhibits breast cancer cell migration and invasion by inducing the degradation of Twist1
Breast cancer is the leading cause of cancer-related deaths in the United States. The majority of deaths (90%) in breast cancer patients…
-
Image creditPhoto by National Cancer Institute on UnsplashPLOS ONE Density of CD3+ and CD8+ cells in gingivo-buccal oral squamous cell carcinoma is associated with lymph node metastases and survival
The tumor immune microenvironment is emerging as a critical player in predicting cancer prognosis and response to therapies. However, the…
-
Image creditPhoto by National Cancer Institute on UnsplashPLOS ONE Divergent organ-specific isogenic metastatic cell lines identified using multi-omics exhibit differential drug sensitivity
Background: Monitoring and treating metastatic progression remains a formidable task due, in part, to an inability to monitor specific…
-
PLOS ONE Mesenchymal stem cells promote metastasis through activation of an ABL-MMP9 signaling axis in lung cancer cells
Mesenchymal stem cells (MSCs) are recruited and activated by solid tumors and play a role in tumor progression and metastasis. Here we…
-
Image creditPhoto by National Cancer Institute on UnsplashPLOS ONE Functional role of vitronectin in breast cancer
Breast Cancer is the most common form of cancer in women worldwide, impacting nearly 2.1 million women each year. Identification of new…