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PLOS Medicine Special Issues

PLOS Medicine Special Issues bring together original research and commentary on priority topics in human health under the guidance of expert Guest Editors. By featuring such work in full open access, the journal seeks to raise broad awareness and accelerate progress in these areas.  Consistent with journal policy, special issues do not receive sponsorship or advertising from companies that produce medical treatments, devices or diagnostics, and all published research articles undergo full peer review.  


Cardiovascular Disease and Multimorbidity

Cardiovascular disease (CVD) is the number one cause of death and disability globally, with an estimated 17.7 million deaths from CVD in 2015.  More than three-quarters of CVD deaths occur in low- and middle-income countries. The demographic shift towards older populations across the globe and the relatively slower decline in morbidity compared with mortality from CVD have resulted in increasing numbers of people with both CVD and other chronic and disabling conditions.

PLOS Medicine will publish a special issue on the identification, prevention, and treatment of CVD with multimorbidity. This special issue will be guest edited by Dr Carolyn S. P. Lam (Duke-NUS Medical School, Singapore), Dr Kazem Rahimi (The George Institute for Global Health, University of Oxford, UK), and Dr Steven Steinhubl (Scripps Translational Science Institute, USA). Read the full Call for Papers, or submit your research to this special issue.


Advances in HIV Prevention, Treatment and Cure

HIV infection continues to pose a critical risk to health in many countries. UNAIDS estimated that at the end of 2015 the total HIV-infected population was 36.7 million, including 2.1 million people newly infected that year. A substantial treatment gap leaves many millions of people at risk of AIDS-related diseases and, if unaware of their status, likely to infect others.

PLOS Medicine will publish a Special Issue on advances in HIV Prevention, Treatment and Cure at the end of 2017. This Special Issue will be guest edited by Dr Linda-Gail Bekker (Desmond Tutu HIV Centre, University of Cape Town); Dr Steven Deeks (University of California, San Francisco); and Dr Sharon Lewin (Peter Doherty Institute of Infection and Immunity, University of Melbourne and Royal Melbourne Hospital). Read the full Call for Papers, or submit your research to this Special Issue.


Traumatic Injury

Traumatic injury has long been recognized as a neglected disease of extremely high burden. Although the nature of traumatic injury and need for swift care pose challenges to research during the immediate response to trauma, high-quality scientific research and clinical evidence in these early phases have the potential to mitigate long term disability and prevent deaths. In July 2017, PLOS Medicine published a Special Issue on Trauma, guest edited by Prof. Karim Brohi (Centre for Trauma Sciences, Blizard Institute, Queen Mary University of London, United Kingdom) and Dr. Martin Schreiber (Division of Trauma, Critical Care, and Acute Care Surgery, Department of Surgery, Oregon Health and Science University, United States).


Dementia Across the Lifespan and Around the Globe – Pathophysiology, Prevention, Treatment, and Societal Impact

Alzheimer’s Disease International (ADI) estimates that in 2015 there were 46.8 million cases of dementia worldwide, with a total cost exceeding US$ 818 billion for the year. In early 2017, PLOS Medicine will publish a special issue on the pathophysiology, prevention, treatment, and societal impact of dementia. This special issue is guest edited by Dr. Carol Brayne, Director of the Cambridge Institute for Public Health at Cambridge University, and Dr. Bruce Miller, Director of the Aging and Memory Center at the University of California San Francisco, and includes commissioned Editorials and Perspectives written by leaders in the field. 


Translating the Cancer Genome — Implications for Diagnosis and Treatment

Over the last few years, dramatic reductions in the cost of sequencing as well advances in sequencing technologies have enabled key insights into the genomic alterations and somatic mutations that lead to cancer and accompany disease progression. For many cancers, the drivers and molecular evolutionary history are now beginning to be understood, and this molecular information is being used to develop novel, and in many cases tailored, therapies. The field is at an exciting juncture: promising results are emerging from immunotherapy and vaccine development programs. In light of this, PLOS Medicine has published a special issue on this topic, guest edited by Dr. Elaine Mardis and Dr. Marc Ladanyi.


Diabetes Prevention

Diabetes is a global problem with recent estimates of a staggering 410 million people with diabetes mellitus in 2013. Furthermore, projections from the International Diabetes Foundation suggest that by 2040 the global burden of diabetes may be as high as 642 million, which would mean that 1 in 10 adults will be living with diabetes. The high risk of disabling and life-threatening complications resulting from poor control of blood glucose, and the enormous individual and societal costs associated with them, demonstrate the urgent need for more effective approaches to prevention. This Special Issue - guest edited by Prof. Nick Wareham and Prof. William Herman - features PLOS Medicine publications that focus on the prevention of diabetes, including lifestyle changes that can elicit reductions in diabetes incidence and how taxes can reduce the number of sugary foods purchased.