The Signaling Pathways Project is a multi-omics knowledgebase based upon public, manually curated transcriptomic and cistromic (ChIP-Seq) datasets involving genetic and small molecule manipulations of…
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Computer & Information Sciences Focus Feature – Genome Landscapes and Phenotype Prediction of DiseaseView Collection
This Focus Feature led by Rachel Karchin and Ruth Nussinov highlights strategies to predict the phenotypic disease consequences of human germline and somatic variation. The rapid growth in genomic…
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Computer & Information Sciences Text MiningView Collection
Across all realms of the sciences, the rapid growth in the number of works published digitally presents new challenges and opportunities for making sense of this wealth of textual information. The…
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Medicine & Health Proceedings of Medicine XView Collection
The Stanford Medicine X program is a leading patient-centered conference on emerging technology and medicine. With aims to catalyze new ideas about the future of medicine and health care, the…
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Biology & Life Sciences Prokaryotic Genome CollectionView Collection
The Prokaryotic Genome Collection aims to present and highlight a number of important articles that describe whole genome sequence and/or comparative genomics of important prokaryotic organisms. We…
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Biology & Life Sciences Editor’s Picks: Uncovering Evolutionary Patterns in the Tree of LifeView Collection
Since the conception of the theory of evolution through natural selection by Charles Darwin and Alfred Russel Wallace, evolutionary biology has become central to our understanding of the natural…
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Computer & Information Sciences Focus Feature – Allostery: Concepts, Methods & ApplicationsView Collection
This Focus Feature, led by Jin Liu and Ruth Nussinov, commemorates the 10th anniversary of PLOS Computational Biology and puts a spotlight on Allostery. The research included is a range of both new…
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Computer & Information Sciences Focus Feature – The Ethics of Big DataView Collection
With exciting new research opportunities comes the much needed consideration of ethical challenges. This Focus Feature, led by Philip E. Bourne, addresses the ethical challenges that accompany the use…
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Medicine & Health Maternal Health Task Force – Year 2: Maternal Health is Women’s HealthView Collection
The theme, “Maternal health is women's health”, was created to highlight the importance of considering maternal health in the context of women's health throughout their lifespans. While…
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Medicine & Health Maternal Health Task Force Year 1: Quality of Maternal Health CareView Collection
While the coverage and reach of maternal health services have increased dramatically in many countries around the world, the quality of those services (both institutional and at the community level…
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Medicine & Health Measuring Coverage in Maternal, Newborn, and Child HealthView Collection
This collection presents innovative assessments of the validity of measuring population coverage for interventions in this field. Coverage indicators are widely used to assess whether interventions…