Biology & Life Sciences

PLOS Special Collections

Read more about PLOS Special Collections on the Special Collections information page

Advances in HIV Mucosal Immunology: Challenges and Opportunities

This collection reports the results of the efforts of investigators, in providing important, practical details on studying immune responses in the genital and rectal mucosa, which will help guide future studies of HIV prevention.

Biodiversity of Saba Bank

This collection of articles represents an international collaboration to characterize the richness, diversity, and habitat affinities of marine taxa on Saba Bank. 

Census of Marine Life

The Census of Marine Life Collections present research from the Census of Marine Life (CoML), a ten-year initiative intended to assess and explain the diversity, distribution, and abundance of marine life in the world's oceans – past, present and future.

Epidemiological Investigations of North American Zoo Elephant Welfare

This collection investigates a series of questions about the welfare of North American zoo elephants using epidemiological methods. The studies provide objective information about how the elephants are faring, identify the most salient connections between their daily lives and a range of behavioral and physical welfare outcomes, and support advances in evidence-based zoological management.

Epigenetics 2010

This collection reflects a range of model systems and organisms, and offer phenotypic, mechanistic, and chromatin-based insights.

GLBIO 2017

A collection of research papers from the 12th Great Lakes Bioinformatics Conference (GLBIO) 2017, organized by the GLBIO Consortium.

Oceanic Metagenomics

The J. Craig Venter Institute's Global Ocean Sampling Expedition revealed an enormous amount of unexplored diversity in the world's oceans. This collection includes commentary and analysis highlighting the achievements and challenges of this work.

PLOS iGEM 2015

PLOS and iGEM share a belief that science is best advanced through openness. Submissions to the PLOS iGEM Collection will be posted for open review on the PLOS Collections blog, where members of the PLOS and iGEM communities will review them openly.

PLOS iGEM 2016

PLOS hosted a realtime online peer review event for iGEM teams ahead of submission to the PLOS iGEM 2016 Collection.

Prokaryotic Genome Collection

The Prokaryotic Genome Collection is an attempt to present and highlight a number of important articles that describe whole genome sequence and/or comparative genomics of important prokaryotic organisms.

RECOMB Regulatory Genomics and Systems Biology 2009

In a joint venture between PLOS Computational Biology, PLOS ONE and the conference program committee, this collection draws together papers from the 6th Annual RECOMB Satellite on Regulatory Genomics and the 5th Annual RECOMB Satellite onSystems Biology, held jointly at MIT, December 2-6, 2009.

RosettaCon 2010

The Rosetta framework for macromolecular modeling, prediction and design is a widely used code with a large, dynamic developer community.  This special collection presents recent developments from the Rosetta community, drawn from the groups participating in RosettaCon 2010.

RosettaCon 2012

The Rosetta framework for macromolecular modeling, prediction and design is a widely used code with a large, dynamic developer community.  This special collection presents recent developments from the Rosetta community, drawn from the groups participating in RosettaCon 2012.

RosettaCon 2014

This special collection describes the results presented at the 2014 RosettaCon conference by participating RosettaCommons labs.

Sauropod Gigantism: A Cross-Disciplinary Approach

This new PLOS Collection discusses major efforts by evolutionary biologists and paleontologists to understand sauropods as living animals and to explain their evolutionary success and uniquely gigantic body size. The articles address these questions from the widest selection of disciplinary viewpoints, including those of ecology, engineering, functional morphology, animal nutrition and palaeontology.

The DREAM systems biology challenges: a Dialogue for Reverse Engineering Assessment and Methods

This Collection contains papers representing the output of the best performing methods in the DREAM challenges, which themselves were discussed and presented at the DREAM (Dialogue for Reverse Engineering Assessment and Methods) conferences, which have been running annually since 2007.

The Genome Network Project/FANTOM3

This collection features articles describing findings that redefine the landscape of the mammalian transcriptome by introducing an extensive collection of novel cDNAs and millions of sequenced tags corresponding to 5'- and 3'-ends of mRNAs.

The Global Burden of Norovirus & Prospects for Vaccine Development

Each year, norovirus causes over 200,000 deaths and a global economic burden of more than $60 billion.  In this PLOS Collection global norovirus experts fill critical knowledge gaps and provide key information to further development of a much-needed vaccine.

The Human Microbiome Project Collection

Funded by the National Institutes of Health Common Fund, the Human Microbiome Project (HMP) was established to provide a comprehensive baseline of the microbial diversity at 18 different human body sites. The Human Microbiome Project Collection encompasses publications from the project.

The Mice Drawer System Experiment and the Space Endurance Record-Breaking Mice

The Italian Space Agency contracted Thales Alenia Space Italia to build a spaceflight payload (Mice Drawer System (MDS)) for mice research on the International Space Station (ISS), including wild type and transgenic strains. These studies examined changes that occurred in the animals.

The Promise of Plant Translational Research

The technical advances highlighted in this collection exemplify how basic research discoveries are being translated into methods to develop and improve, both agriculturally and environmentally, important crop traits.

The World Register of Marine Species

This Collection has been created by the editors of the World Register of Marine Species, an open-access online database which holds information on all marine species, and some of their freshwater and terrestrial relatives.

Visceral Leishmaniasis and HIV Co-Infection

PLOS Neglected Tropical Diseases has dedicated a special collection to VL-HIV co-infection including basic and molecular work, immunological and diagnostic studies, clinical studies, and public health aspects.


Leishmaniasis research papers from the call for papers made by the WorldLeish-6 Scientific Committee, in partnership with PLOS Collections.

PLOS Archive Collections

Spotlight Archive Collection 

How Microbes ‘Jeopardize’ the Modern Synthesis

This collection presents a series of reviews focused on the expansion and clarification/limitation of the tools scientists use to study microbial evolution.


2009 Maize Genome

A Collection of Interviews by Jane Gitschier

Aging: Bench to Bedside

Bridging Communities: Co- and Polymicrobial Infections

Cancer Research

Challenges Collection

Chemical Tools & Probes

Clinical Immunology Collection

Craniofacial Genetics

Deep Reads


Ecological Impacts of Climate Change

Editor’s Picks: Experimental Biology

Editor’s Picks: Human Genetics

Editor’s Picks: Molecular Biology & Biochemistry

Editor’s Picks: Uncovering Evolutionary Patterns in the Tree of Life

Editor’s Picks: Stem Cell Research

Editor's Picks: Autophagy

Editor's Picks: Cell Biology

Editor's Picks: Microbiology

Editor's Picks: Single Cell Genomics

Focus Feature - Network Approaches and Applications in Biology

Genetically Modified Insect

Genomics of Emerging Infectious Disease


Malaria: Targets and Drugs for All Stages

Marine Megafauna Collection

Neuromapping and Therapeutics

Neuroscience Collection 

Open Highlights

PLOS Genetics Research Prize

PLOS Genetics: 10th Anniversary

PLOS Neglected Tropical Diseases: 10th Anniversary Collection

PLOS Neglected Tropical Diseases: Top Ten Research Article Collection

PLOS Pathogens Pearls

PLOS Pathogens & PLOS Neglected Tropical Diseases Twinning Collection

PLOS Pathogens: 10th Anniversary Collection

Public Engagement in Science

Slice of PLOS

Stress-Induced Depression and Comorbidities: From Bench to Bedside

Structural Biology and Human Health: Medically Relevant Proteins from the SGC

Synthetic Biology

Tenth Anniversary PLOS Biology Collection

The Paleontology Collection

Tsetse Genome Biology Collection

Understanding Images

Up For A Challenge (U4C) – Stimulating Innovation in Breast Cancer Genetic Epidemiology


Yellow Fever


How Microbes ‘Jeopardize’ the Modern Synthesis