Medicine & Health Sciences


Calls for Papers for PLOS Collections

Maternal and Child Health & Nutrition

PLOS Medicine and PLOS ONE

Gender and Equity Research

PLOS Neglected Tropical Diseases and PLOS ONE

Targeted Anticancer Therapies and Precision Medicine in Cancer

PLOS Computational Biology and PLOS ONE 

Substance Use, Misuse and Dependence: Prevention and Treatment

PLOS Medicine and PLOS ONE

Antimicrobial Resistance

PLOS ONE, PLOS Biology, PLOS Medicine and PLOS Neglected Tropical Diseases

Early Diagnosis and Treatment of Alzheimer's Disease


PLOS Special Collections 

Read more about PLOS Special Collections on the Special Collections information page


Replication of influential studies evaluating interventions for HIV prevention and treatment

Three decades of work on HIV prevention and treatment have yielded effective biomedical, behavioral, social, and structural interventions in controlled trials. Few of these have been adopted at a population level to prevent HIV. The effort needed to scale up any evidence-based intervention requires the results to be carefully reviewed, understood and confirmed. The International Initiative for Impact Evaluation (3ie) funded this Collection of replication studies to address this gap. The research covers topics related to HIV and AIDS, attempts to reproduce the original findings using existing data and any available study materials. 


Advances in Clinical Trial Design for Development of New Treatments for Tuberculosis

With recent opportunities to test combinations of new and repurposed drugs for the treatment of TB, new questions arise for optimal clinical trial design. To address these, in March 2018 WHO organized a consultation on “Advances in Clinical Trial Design for New TB Treatments” to identify and outline the optimal characteristics of clinical trial designs to inform policy guidance for new TB regimens. This PLOS Medicine Special Collection assembles a series of articles on current reflections and describes essential new steps in clinical research that will pave the way for the development of tomorrow’s optimal treatment for all forms of TB.


Epidemiological metrics for the HIV epidemic

Extraordinary progress has been made to halt and reverse the spread of HIV. However, there is still a long way to go to end the epidemic, as called for in the third Sustainable Development Goal. This collection reviews metrics to understand progress in diverse HIV epidemics. It considers both the public health and the human rights lessons learned from other infectious diseases and provides suggestions to evaluate the success of global, national and local HIV responses. 


Economic Cases for NCD Prevention and Control: A Global Perspective

Economic Cases for NCD Prevention and Control expands the evidence base on the economic burden of noncommunicable diseases (NCDs) and the impact of NCD prevention and control programs globally. This Collection highlights investment cases, economic evaluations of interventions, and economic impacts on households, health systems, and nations. This Collection was produced by the International NCD Economics Research Network, a coalition of academic, governmental, and non-governmental partners, chaired by Centers for Disease Control and Protection, RTI International, and University of Illinois, Chicago. 

Flubendazole in Onchocerciasis

Treating onchocerciasis remains a challenge as no drug effectively kills the adult worms. A new orally bioavailable formulation of flubendazole was developed and tested to find out whether it could be a safe and effective macrofilaricidal drug. The introduction to this collection explains the history and rationale for development. The subsequent 3 articles report on the efficacy, PK and safety as observed in animal models. The last article summarizes the toxicology and preclinical PK data generated with this new flubendazole formulation. It also explains that the decision to discontinue its development was taken because no safe and effective dose could be selected for use in clinical trials.

NTD Modelling Consortium: Insights on data needs

As Neglected Tropical Disease (NTD) programs move towards the 2020 goals, there is a need to strengthen data collection and evaluation for decision making. Mathematical modelling has an important role in evaluating current monitoring and evaluation data and discussing alternatives, as well as in evaluating whether additional data is needed to understand key epidemiological uncertainties.

Burden of Infectious Diseases in Europe 

The Burden of Communicable Diseases in Europe (BCoDE) aimed to estimate the burden of communicable diseases applying a pathogen and incidence based approach to estimating DALYs (Disability Adjusted Life Years). This collection brings together papers on the methodology and on resulting disease burden estimates for a variety of settings.

Sport and Exercise Science

This collection reflects the interdisciplinary nature of this discipline – with topics ranging from Neuromuscular Biology to Exercise Behaviour – and the growing scientific interest in the limits and capabilities of the human body.

Fortification Assessment

This collection highlights fortification coverage results from a series of surveys across diverse countries in Africa and Asia using the Fortification Assessment Coverage Toolkit (FACT).


This collection highlights approaches needed for generating soil-transmitted helminths evidence to inform intervention strategies and policy changes.

High Quality Health Systems

The collection on High Quality Health Systems will publish a range of research papers on the measurement, improvement, and ethics of health system quality. 

malERA - An updated research agenda for malaria elimination and eradication

‘malERA Refresh’ is a research and development agenda that accelerates progress towards malaria elimination and eradication. This collection sets out a multi-disciplinary agenda for research, development and innovation.

Trafficking, Exploitation and Health

This PLOS Collection offers evidence and expert commentary to urge health professionals to treat trafficking as a global health determinant.

Economic Efficiency of HIV Services

This collection presents recent, high-quality evidence from low- and middle-income countries on costs and technical efficiency of HIV services and their determinants. 

Advances in HIV Prevention, Treatment and Cure

Although some 19.5 million people are receiving antiretroviral treatment for HIV, a substantial treatment gap leaves many millions of people at risk of AIDS-related diseases and, if unaware of their status, likely to infect others. The research in this collection seeks new approaches to prevent, treat, and ultimately cure HIV infection.

Up For A Challenge (U4C) – Stimulating Innovation in Breast Cancer Genetic Epidemiology

The four winning articles from the National Cancer Institute’s competition appear in this special collection, published by PLOS Genetics.

Traumatic Injury

This PLOS Medicine Special Issue, guest edited by Professor Karim Brohi and Dr Martin Schreiber, highlights crucial research in the area of traumatic injury.


PLOS NTDs has long been a home for vector research. With this collection, we aim to curate the cutting edge of vector research from the global NTDs community.

The Prevention, Diagnosis and Treatment of Sexually Transmitted Infections

A collection of research studies and magazine articles on the prevention, diagnosis, and treatment of sexually transmitted infections (STIs).

Minimally invasive autopsy for cause of death determination in high burden settings

A series of studies on minimally invasive autopsy, a tool for cause of death investigation in middle and low-income countries.

Dementia: Across the Lifespan & Around the Globe

This PLOS Medicine Special Issue, guest edited by Carol Brayne and Bruce Miller, includes research articles, editorials, and perspectives that highlight the broad range of dementia research. 

Editor’s Pick: Cancer Immunotherapy

PLOS ONE Associate Editor Jenna Wilson highlights recent research on potential immunotherapies and the cancer immune environment, to learn how to harness the body’s immune system to fight cancer.

PLOS Neglected Tropical Diseases: 10th Anniversary Collection

The articles in this collection reflect on significant lessons and successes in the field over the past decade since the journal launched.

Yellow Fever

PLOS NTDs Editor-in-Chief Serap Aksoy has assembled a collection of previously-published Yellow Fever research articles that are of interest considering the 2015-2016 outbreaks of Yellow Fever in Africa and Brazil.


Leishmaniasis research papers from the call for papers made by the WorldLeish-6 Scientific Committee, in partnership with PLOS Collections.

WASH - Water, Sanitation and Hygiene​

PLOS journals are committed to highlighting the impact of WASH and allied measures on reducing the global burden of disease.

Editor’s Picks: Regenerative Medicine

PLOS ONE Senior Editor Christna Chap selects recent PLOS publications highlighting the cross-disciplinary nature of regenerative medicine.

Good Clinical Practice

Experiences, lessons learnt and practical tools developed during clinical research on NTDs in Africa and Asia.

Bridging Communities: Co- and Polymicrobial Infections

PLOS Pathogens presents Research Articles that directly tackle how overlapping infections, and the immune responses they stimulate, might interact in novel ways.

The Global Burden of Norovirus & Prospects for Vaccine Development

Each year, norovirus causes over 200,000 deaths and a global economic burden of more than $60 billion.  In this PLOS Collection global norovirus experts fill critical knowledge gaps and provide key information to further development of a much-needed vaccine.

Cancer Research

New research is being regularly published on preventing and curing cancer. This Collection highlights cancer research published in PLOS journals.

Editor’​s Picks: Stem Cell Research

PLOS Staff Editors Eric Martens, Ines Alvarez-Garcia and Jenna Wilson share recent PLOS articles highlighting the many facets of stem cell research.

Grand Convergence: Aligning Technologies & Realities in Global Health

This collection describes how to reduce avertable infectious, maternal, and child deaths down to universally low levels within a generation by aggressively scaling up health tools and continuing to invest in the tools of tomorrow.

VMMC for HIV Prevention: New Mathematical Models for Prioritizing Sub-Populations by Age & Geography

Featuring mathematical modeling that aim to help decision-makers examine the potential effects of targeting sub-populations for voluntary medical male circumcision.

Combating NTDs: Lessons from India

In this collection PLOS Negelected Tropical Diseases highlights the contributions of Indian authors, labs, and institutions to the global fight against neglected tropical diseases.


The impact of zika, an arbovirus infection transmitted by several different species of Aedes mosquitoes, should be treated with the utmost seriousness as the impact could be devastating.

Diabetes Prevention

PLOS Medicine announce a Special Issue on Diabetes Prevention to be guest edited by Professors Nick Wareham & William Herman. Submissions are now being accepted.

Translating the Cancer Genome

PLOS Medicine announce a call for papers for a special issue to be guest edited by Dr Elaine R Mardis & Dr Marc Ladanyi. 

Real-Time Monitoring of Under-Five Mortality

The results of a five-year program of research focused on improving the measurement of short-term changes in neonatal and child mortality in low-resource settings.


Mycetoma is a serious and debilitating condition that meets all of the criteria we ordinarily attribute to a neglected tropical disease (NTD).

WHO Estimates of the Global Burden of Foodborne Diseases

Illness and death from diseases caused by contaminated food are a constant threat to public health and a significant impediment to socio-economic development worldwide. This Collection reports the first estimates of the incidence, mortality, and disease burden caused by 31 foodborne hazards.

PLOS Genetics: 10th Anniversary

2015 marks the tenth anniversary of PLOS Genetics and brings with it a host of celebrations to mark this momentous occasion. This collection exhibits some of the best research PLOS Genetics has had the privilege to publish over the past decade.

PLOS Pathogens: 10th Anniversary Collection

To celebrate the 10th anniversary of the launch of PLOS Pathogens, over 60 Section Editors, all experts on studies of viruses, bacteria, prions, fungi, oomycetes and parasites of animals and plants, were invited to select articles that they believed represented the very best exemplars from their respective fields.

PLOS Medicine: Cancer Research

To coincide with the meeting of the American Association for Cancer Research (AACR), to be held in Philadelphia from April 18 to 22, 2015, PLOS Medicine launches this open access collection of recently published articles representing the full spectrum of clinically relevant cancer research and commentary, from translational to clinical to epidemiological.

40 Years of the APOC Partnership

This collections looks at the impact that the African Program for Onchocerciasis Control (APOC) has had over the last 40 years and how it has played a key role in reducing the rates of blindness caused by onchocerciasis.

Clinical Immunology Collection

The Clinical Immunology Collection includes sections on Allergies & Anaphylaxis, Tumor Immunology, Immunodeficiency and Autoimmune Diseases.

Monitoring Universal Health Coverage

13 country case studies, five technical reviews and an overview describe a global framework for monitoring progress towards Universal Health Coverage (UHC) conducted by the World Health Organisation (WHO) and the World Bank Group.

Focus on Delivery and Scale: Achieving HIV Impact with Sex Workers

Up-to-date analyses on both the influence of direct and indirect intervention programmes aimed at interrupting the high-incidence of HIV infection amongst sex workers.

Voluntary Medical Male Circumcision for HIV Prevention: Improving Quality, Efficiency, Cost Effectiveness, and Demand for Services during an Accelerated Scale-up

This collection examines lessons learned from the scaled-up VMMC program since 2008.

Pediatric Medicine

In a commitment to increasing the evidence base for improving child health, PLOS journals publish high-quality, Open Access research and commentary on Pediatric Medicine, ensuring this crucial evidence is freely available to read and use throughout the world without restriction.


In response to the 2014 Ebola outbreak in West Africa, PLOS editors curated content from across the seven journals, PLOS Currents and the PLOS Blogs Network into a rapidly evolving collection of research.

Malaria: Targets and Drugs for All Stages

This Collection describes multiple parasite and host processes engaged in infection in blood, the blocking of which could stop human illness, along with the development of drugs against stages responsible for mosquito transmission and those that remain latent in the liver.

Blue Marble Health: the mismatch between national wealth and population health

"Blue marble health" is a recent concept that recognizes a paradoxical disease burden – particularly the burden of NTDs – among poor people living in G20 and other wealthier countries.

Measuring Coverage in Maternal, Newborn, and Child Health

Innovative assessments of the validity of measuring population coverage for interventions in this field, exploring issues around household surveys, assessment of health inequalities, consideration of survey error, and the generation of indicators for global monitoring.

PLOS Pathogens Pearls

PLOS Pathogens presents an Open Access compendium of "lessons-that-last." This living collection of short, educational, and highly useful articles addresses topics of relevance and importance within the wide-ranging field of pathogens research, with insights tailored to graduate students and post-docs.

The Global Challenges of Noncommunicable Diseases

This Collection brings together research and commentary published in PLOS Medicine that examines the global challenges and opportunities for addressing noncommunicable disease around the world.

Child Mortality Estimation Methods

In this collection of research articles and reviews the independent Technical Advisory Group (TAG) to the UN IGME introduces the group's methodological innovations in estimating child mortality.


Highlighting this somewhat mysterious yet very important neglected tropical disease, its enormous potential global impact on human health, and the urgent need for basic and applied research.

PLOS and DNDi: A Decade of Open Access and NTD R&D

This Collection showcases some of the most important papers published on R&D of drugs for neglected tropical diseases over the last decade – including papers from PLOS Medicine, PLOS Neglected Tropical Diseases and PLOS ONE.

MHTF Year Five: Non-Communicable Diseases and Maternal Health Around the Globe

This collection aims to draw attention to issues surrounding non-communicable diseases, with a particular focus on risk factors and implications for reproductive or maternal health. 

MHTF Year Four: Neglected Populations: Decreasing Inequalities and Improving Measurement in Maternal Health

Through this collection, we draw attention to issues of inequality within maternal health, with a particular focus on new measurement tools and approaches to track disparities and guide efforts to reduce them.

MHTF Year Three: Integrating Health Care to Meet the Needs of the Mother–Infant Pair

Each year the PLOS Maternal Health Task Force Project had a different focus. In Year Three, the theme was "Integrating Health Care to Meet the Needs of the Mother–Infant Pair.”

MHTF Year Two: Maternal Health is Women’s Health

Each year the PLOS Maternal Health Task Force Project had a different focus. In Year Two, the theme was "Maternal Health is Women’s Health.”

MHTF Year One: Quality of Maternal Health Care

Each year the PLOS Maternal Health Task Force Project had a different focus. In Year One, the theme was "quality of maternal health care.”

Visceral Leishmaniasis and HIV Co-Infection

PLOS Neglected Tropical Diseases has dedicated a special collection to VL-HIV co-infection including basic and molecular work, immunological and diagnostic studies, clinical studies, and public health aspects.

Advances in HIV Mucosal Immunology: Challenges and Opportunities

This collection reports the results of the efforts of investigators, in providing important, practical details on studying immune responses in the genital and rectal mucosa, which will help guide future studies of HIV prevention.

TDR Reflects on 40 Years

Former and current staff of the Special Programme in Research and Training in Tropical Disease (TDR) provide their views on key challenges and lessons learned during the 40 year history.

Investigating the Impact of Treatment on New HIV Infections

In November 2011 the HIV Modelling Consortium held a meeting on the cross-cutting issues of the impact of new scientific findings about HIV treatment preventing new infections. The group considered the feasibility of interventions, potential epidemiological impact, affordability and community trials.

World Health Report 2012: No Health Without Research

This collection's theme is oriented around the fact that decisions on healthcare are still made without a solid grounding in research evidence, and an impetus is required for this state of affairs to change.

Big Food

A multi-disciplinary approach, including critical perspectives from around the world, that examines and stimulates debate about the activities and influence of the food industry in global health.

A Research Agenda for the Control and Elimination of Human Helminthiases

A three part series examining the emergence of eHealth – the use of electronic tools in delivering health care – and its benefits and challenges worldwide.

Voluntary Medical Male Circumcision for HIV Prevention: The Cost, Impact, and Challenges of Accelerated Scale-Up in Southern and Eastern Africa

Can scaling up VMMC for HIV prevention Africa help prevent HIV as well as leading to substantial cost savings for countries as a result of averted treatment and care costs?

Migration & Health

Policies to protect migrants and global health have so far been hampered by inadequate policy attention and poor international coordination – PLOS Medicine investigate in this six-part series.

Sleeping Sickness

Key papers published in PLOS Neglected Tropical Diseases on human African trypanosomiasis (HAT), more familiarly known as sleeping sickness.

Water and Sanitation

The active involvement of health professionals in hygiene, sanitation, and water supply is crucial to accelerating and consolidating progress for health – in November 2010, PLOS Medicine published a four-part series on this topic.

malERA – a research agenda for malaria eradication

The Malaria Eradication Research Agenda (malERA) initiative complements existing research agendas aimed at reducing the global burden of  malaria by malaria control, with a set of research and development priorities that identify knowledge gaps and tools needed for worldwide eradication of malaria. 

Global Health Estimates

Six articles from a series of experts provide insights and opinion on what estimates of global health indicators mean for global health and how to move forward with better data, measurement, coordination, and leadership.

Are Drug Companies Living Up to Their Human Rights Responsibilities?

The PLOS Medicine Debate asks whether drug companies are living up to their human rights responsibilities.

Evaluating eHealth Collection

A three part series examining the emergence of eHealth – the use of electronic tools in delivering health care – and its benefits and challenges worldwide.

Health Consequences of the Asian Tsunami

In order to revisit the health consequences of the Asian tsunami of December 2004 six months on, PLOS Medicine commissioned a collection, published in April 2005 and later updated with new research.

Social Medicine in the 21st Century

A special collection of eleven magazine articles and five research papers devoted entirely to social medicine. The collection featured many of the leaders in the field, including Paul Farmer, Arthur Kleinman, David Satcher, Nancy Scheper-Hughes, Dorothy Porter, and Leon Eisenberg.

Grand Challenges in Global Health

In this special collection, four policy papers cover a range of ethical, social, and cultural issues related to the Grand Challenges in Global Health Initiative.


The Council of Science Editors organized a Global Theme Issue on Poverty and Human Development on October 22, 2007. More than 200 science and health journals, including PLOS Medicine, PLOS Biology, and PLOS Neglected Tropical Diseases, participated by publishing new articles.

Mental Health in Low- and Middle-Income Countries

Between October 2009 and February 2010 PLOS Medicine published a seven part series of articles proposing "packages of care" for mental, neurological, and substance-use disorders in low- and middle-income countries


In several PLOS Neglected Tropical Diseases papers on rabies scientists describe the situation of canine rabies control in developing countries, as well as various recent advances in the development of vaccines and treatments that will contribute to the elimination of human deaths from rabies.

Global Health Diplomacy

A six-part series on global health diplomacy, published by PLOS Medicine in April 2010.

Sub-Saharan Africa's Mothers, Newborns, and Children

A series of articles on maternal, newborn, and child health in sub-Saharan Africa, providing a snapshot of the health and causes of death among the region's mothers and children, reviews evidence-based solutions, and identifies high-impact opportunities for reducing maternal and child mortality.

Disease Mongering

To mark the first academic meeting on disease mongering (the "selling of sickness" in order to promote drug sales), which was held in Newcastle, Australia in April 2006, and to help provoke and inform a response to the phenomenon, PLOS Medicine commissioned a special theme issue

Tsetse Genome Biology Collection

This collection contains manuscripts that describe functional findings on various tsetse biology. In addition two manuscripts reflect on the unique historical aspects of sleeping sickness epidemics that have plagued sub-Sahara in the 20th century

Proceedings of Medicine X

The Stanford Medicine X program is a leading patient-centered conference on emerging technology and medicine. With aims to catalyze new ideas about the future of medicine and health care, the conference has generated a selection of articles as featured in this collection.

Genomics of Emerging Infectious Disease

This collection of essays, perspectives, and reviews from six PLOS Journals provides insights into how genomics can revolutionize our understanding of emerging infectious disease.

PLOS Neglected Tropical Diseases: Top Ten Research Article Collection

To commemorate the Fifth Anniversary of the launch of PLOS NTDs, we are releasing a collection of the most-viewed research articles from each of the five years that the journal has published

Genetically Modified Insect

These articles describe the technical and applied aspects of GM insects. We have also included articles that are not strictly GM, but aim to modify the disease transmission traits of insects through the use of symbiotic microbes.

Stress-Induced Depression and Comorbidities: From Bench to Bedside

This collection of articles represents the output of a group of international research institutions (informally referred to as EUMOOD) who collaborated around the causal link between stress exposure and depression vulnerability.

PLOS Neglected Tropical Diseases: Historical Profiles and Perspectives

To commemorate the Fifth Anniversary of the launch PLOS Neglected Tropical Diseases a number of "Historical Profiles and Perspectives" articles were published, highlighting individual researchers or institutions that have contributed significantly to progress within the field.

Neuromapping and Therapeutics

The NeuroMapping and Therapeutics Collection contains a selection of articles published in PLOS ONE that are representative of the aims and scope of Society of Brain Mapping and Therapeutics.

The Changing Nature of Global Health Institutions

A four-part series from PLOS Medicine examining the ways in which global health institutions and arrangements are changing and evolving.


Ghostwriting misrepresents authorship credit and accountability and is therefore considered unethical, dishonest, and a threat to the integrity of the medical literature.This collection gathers together research and commentary from PLOS journals on the topic of ghostwriting.

The Geopolitics of Neglected Tropical Diseases

To commemorate the Fifth Anniversary of the launch of PLOS Neglected Tropical Diseases, this collection focuses on geographic perspectives on the global burden of the neglected tropical diseases.

Epigenetics 2010

This collection reflects a range of model systems and organisms, and offer phenotypic, mechanistic, and chromatin-based insights.

PLOS Pathogens & PLOS Neglected Tropical Diseases Twinning Collection

PLOS Pathogens and PLOS Neglected Tropical Diseases sent a collection of primary research articles on topics spanning these sister journals, including: proteomics, kinetoplastids, insect vectors, genomics, and transcriptomics within the context of the NTDs.

Structural Biology and Human Health: Medically Relevant Proteins from the SGC

This collection of articles represents some of the research highlights from the SGC, an international public-private partnership that determines three dimensional structures of medically important proteins from both human and human parasites and places this information into the public domain, free from restrictions on use. 

The Human Microbiome Project Collection

Funded by the National Institutes of Health Common Fund, the Human Microbiome Project (HMP) was established to provide a comprehensive baseline of the microbial diversity at 18 different human body sites. The Human Microbiome Project Collection encompasses publications from the project.