The Signaling Pathways Project is a multi-omics knowledgebase based upon public, manually curated transcriptomic and cistromic (ChIP-Seq) datasets involving genetic and small molecule manipulations of…
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Medicine & Health Voluntary Medical Male Circumcision for HIV Prevention: New Mathematical Models for Prioritizing Sub-Populations by Age & GeographyView Collection
This PLOS Collection features new mathematical models that can help country decision-makers examine the potential effects of targeting sub-populations for voluntary medical male circumcision services…
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Medicine & Health Advances in HIV Prevention, Treatment and CureView Collection
HIV infection continues to pose a critical risk to health in many countries. UNAIDS estimates that as of 2016 the total HIV-infected population was 36.7 million, including 1.8 million people newly…
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Medicine & Health Climate Change and HealthView Collection
Climate change and the impacts on health are being increasingly reported and documented. It is expected that with continued rises in global temperature and greenhouse gas emissions the effects on…
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Research Analysis & Policy Meta-Research: Policy and InterventionsView Collection
Meta-research, or the scientific study of research practices, aims to characterize existing standards and ultimately improve the quality and reliability of scientific research. We collect here…
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Research Analysis & Policy Meta-Research: Tools for Improving Biomedical ResearchView Collection
Meta-research, or the scientific study of research practices, aims to characterize existing standards and ultimately improve the quality and reliability of scientific research. We collect here…
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Research Analysis & Policy Meta-Research: MethodsView Collection
Meta-research, or the scientific study of research practices, aims to characterize existing standards and ultimately improve the quality and reliability of scientific research. We collect here…
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Medicine & Health The Global Challenges of Noncommunicable DiseasesView Collection
Noncommunicable diseases (NCDs) are responsible for two-thirds of the world's deaths, one-fourth of which occur before the age of 60. Nearly 80% of NCD deaths occur in low- and middle-income…
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Medicine & Health Epidemiological metrics for the HIV epidemicView Collection
Extraordinary progress has been made to halt and reverse the spread of HIV. However, there is still a long way to go to end the epidemic, as called for in the third Sustainable Development…
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Medicine & Health Cardiovascular DiseasesView Collection
Cardiovascular disease (CVD) is the number one cause of death and disability globally, with an estimated 17.7 million deaths from CVD in 2015. More than three-quarters of CVD deaths occur in low- and…
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Medicine & Health Traumatic InjuryView Collection
Traumatic injury has long been recognized as a neglected disease of extremely high burden. With this Special Issue, PLOS Medicine and guest editors Professor Karim Brohi and Dr Martin Schreiber…