The Signaling Pathways Project is a multi-omics knowledgebase based upon public, manually curated transcriptomic and cistromic (ChIP-Seq) datasets involving genetic and small molecule manipulations of…
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Computer & Information Sciences Focus Feature – Genome Landscapes and Phenotype Prediction of DiseaseView Collection
This Focus Feature led by Rachel Karchin and Ruth Nussinov highlights strategies to predict the phenotypic disease consequences of human germline and somatic variation. The rapid growth in genomic…
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Computer & Information Sciences Text MiningView Collection
Across all realms of the sciences, the rapid growth in the number of works published digitally presents new challenges and opportunities for making sense of this wealth of textual information. The…
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Computer & Information Sciences Focus Feature – Allostery: Concepts, Methods & ApplicationsView Collection
This Focus Feature, led by Jin Liu and Ruth Nussinov, commemorates the 10th anniversary of PLOS Computational Biology and puts a spotlight on Allostery. The research included is a range of both new…
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Computer & Information Sciences Focus Feature – The Ethics of Big DataView Collection
With exciting new research opportunities comes the much needed consideration of ethical challenges. This Focus Feature, led by Philip E. Bourne, addresses the ethical challenges that accompany the use…
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Computer & Information Sciences Translational BioinformaticsView Collection
'Translational Bioinformatics' is a collection of articles which reads as a "book" to be used as a reference or tutorial for a graduate level introductory course on the science of…
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Computer & Information Sciences PLOS Computational Biology: 10th AnniversaryView Collection
Ten years ago, on June 24th 2005, the inaugural issue of PLOS Computational Biology was published, making June 2015 the 10th Anniversary. To mark the occasion, this new collection exhibits the best…
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Computer & Information Sciences Macromolecular Structure and DynamicsView Collection
In this collection of newly published research articles, Ruth Nussinov (Editor-in-Chief) and Amarda Shehu (George Mason University, USA) highlight some of the latest advancements in computational…
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Computer & Information Sciences Core FacilitiesView Collection
Biomedical research is benefiting from the wealth of new data generated in the laboratory through new instrumentation, greater computational resources, and massive repositories of public domain data…
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Computer & Information Sciences About My LabView Collection
This collection was launched with the mission to share knowledge about lab organization and scientific management. Each Perspective article represents an interview with a Principal Investigator, who…
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Biology & Life Sciences RosettaCon 2012View Collection
The Rosetta macromolecular modeling, prediction, and design software suite is supported by a large developer community and enjoys a diverse user base. Each year Rosetta developers and users from…